Do regulon make you fat? Regulon reviews from medical specialists

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The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

It turns out that representatives of the fair sex who use regulon undergo the same processes in their bodies as a woman in the first weeks of pregnancy. And if this drug is taken for a long time by a woman who has already had children, then exactly the same processes occur in her reproductive system as in women who gave birth and nurtured twelve of their own children. That is, this drug actually does what nature itself would do, in the end, if women dared to undertake such feats. Having a large number of children, by the way, is the most effective method of preventing cancer of the mammary glands and genital organs.

Such data completely refute the talk that taking Regulon and other hormonal contraceptives of the latest generation is necessary to take breaks for several months. In fact, such breaks are completely unnecessary. Today, doctors believe that breaks in the use of this drug and other hormonal contraceptives can harm a woman’s health.

The longer a woman takes Regulon without intervals, the stronger the therapeutic effect of the drug. Such drugs should be taken as soon as sexual activity begins and used as long as there is a need for contraception. It turns out that among patients who use hormonal contraceptives, the percentage of women with infertility is several times lower than among those who have never used such drugs. When using this drug for a long time, the best conditions are created in the body for the maturation of eggs. To maintain the reproductive system in proper condition, you should take vitamin dietary supplements (dietary supplements).

Before use, you should consult a specialist.

Reviews

Please answer, I am 54 years old.
At the age of 50, menopause began slowly. Not on the advice of a doctor, but on the advice of a friend, I started taking Regulon. My periods have returned, all these hot flashes, sweating, etc. have gone away. I feel, taking it, it’s great, without it, the same thing begins. I've been taking it for 3 years now. I never stopped receiving it. Should I go and tell the doctor about this? I think that at 54 I won’t get pregnant anymore. Please advise or tell me if this is normal?

I have been drinking Regulon for 8 years without a break... I gave birth and immediately started drinking, I have not observed any side effects, I am 33 years old and feel great

Hello! I have been suffering from a rash on my face for a year now, I had cervical excision (erosion) a year ago, I have two children. Menstruation is always painful, now I started drinking regulon, as prescribed, on the first day of menstruation. There are no new rashes on my face, it pleases me already, I have been drinking for 5 days, my periods are calm, nothing hurts, it doesn’t pull, it doesn’t ache, and somehow it seemed to me that they were distributed, that is, not chaotically. Weight - over the past month I have been treating blood vessels, I have recovered and so decently, but now I will monitor my weight.

I took regulon for 2 years, there were no side effects, I did not gain any weight. Later, my husband and I decided to have a second child, I stopped drinking them and got pregnant exactly 6 months later, everything was fine. Now my baby is 6 months old, unfortunately my milk is gone and I started taking regulon again, absolutely everything is the same, there are no problems, so I advise.

I was prescribed Regulon for therapeutic purposes, to normalize my cycle. The level of female sex hormones was very low. The whole thing threatened with an early menopause. They called me menstruation, prescribed Regulon for 6 months. What happened to me, I can't tell you. Chest +2 sizes, terrible constant pain, weight +5 kg., Then my legs started to hurt, at night I woke up from a terrible pain as if someone had beaten the bones of my legs. It took 3 months to get used to it. Then everything is fine. But at the 6th month of taking hemorrhoids appeared, itching in the vagina, thrush. The hair began to fall out (((The last 4 pills left to drink. And I ran to the mammogram and to the appointment with the gynecologist. I'll see what I have healed!

I was prescribed Regulon after a medical abortion. I've been drinking for 5 months now. I gained a lot of weight, but my libido decreased. I eat everything that is not nailed down)) You can say it feels like toxicosis (believe me, I know these feelings, I already have a child). Regarding appearance, I can also note: hair loss, brittle nails, acne on the forehead, dull facial skin and pale lips. I went to the gynecologist and she gave me other OCs. I’m currently on OK because I’m waiting for permission to put in an IUD, but it’s not being installed as a consequence of the fact that the cauterization was done incorrectly, due to erosion of the uterine lining. So it suits who. It didn't suit me personally.

After treating the cyst, the doctor prescribed Regulon for me to drink for 20 days, break for 7 days, so three plates. But I drank two plates because I couldn’t drink them anymore, I felt sick, my breasts grew two sizes, they hurt a lot, at night it didn’t let me sleep, it was not possible to sleep on my stomach at all, when I drank the second plate completely I went away menstruation, in the lower abdomen I had severe pain, like during menstruation, but I never have pain, excuse me, blood clots came out of me, some tissue similar to pieces of meat and a lot of blood, and before that I had problems with menstruation It was sometimes not, and then it was just brown discharge, I wouldn’t call it menstruation. Now I don’t take them anymore and my breasts are sagging, it’s just terrible, I haven’t recovered.

I’ve been taking Regulon for two weeks. My breasts have become very enlarged and it seems that I’m getting better. But otherwise everything is fine. I’ll tolerate the excess weight because I really want a child. The doctor pre-prescribed them for me after a miscarriage...

Tell me, can you take Regulon only for 3 months? Or constantly?

I take Regulon because my periods are not regular, and pregnancy does not occur, the doctor prescribed me to take it for three months, after which I need to have a laparoscopy! I’ve been drinking for two months now, yesterday I forgot to drink (I drink at 20.00) I had an unprotected PA, could I get pregnant? I don’t know if I should take the pill today (I really want a baby)

I have been taking Regulon since the 3rd day of my period to treat a follicular cyst. At first I had problems with my eyes, I had to give up contacts and wear glasses. Then a smear of brown and blood began. And sometimes the ovary pulls. The cyst resolved without regulon on the 5th day of the month. She was no longer there on the ultrasound. But it’s not advisable to quit drinking in the middle of the cycle, so I’m struggling with it. By the way, I haven’t gained a single gram of weight.

I bought Regulon after an abortion, but never took a single pill. My MC was off, my weight was constantly fluctuating. The gynecologist generally said they shouldn’t be used for inflammation of the ovaries and suggested buying low-dose ones like trigistrel and Oralcon. Is it possible to combine them? I’ll take Regulon and Oralcon then ??I plan to get pregnant as soon as women’s health allows.

I took the first pill... I'll see what happens. ...I hope I don’t get fat...very scary. ..prescribed because of a ruptured ovary and cysts...I would like to continue it as a contraceptive. I’ll post how I finish the course or how I feel changes. ......

I took Regulon for 3 months. My breasts have grown by more than one size. I just stopped getting excited completely. became indifferent to the guy. drank for medicinal purposes. So I got treatment and had to quit. because there was no point in taking pills if there was no desire at all......but I stopped taking them and after 2-3 weeks the desire woke up...so it’s very individual. and in terms of contraception they are wonderful

Lena, don’t abuse your body! You are who you should be. Stop taking the drug, don’t make yourself look like a disabled person, there are very bad consequences from taking it. Read the side effects - they actually all affect everyone.

Regulon from the Hungarian pharmaceutical company GEDEON RICHTER is a monophasic tablet contraceptive. When the first contraceptives were synthesized in the fifties of the last century, hardly anyone could have imagined that their therapeutic effect on the female body would be valued almost more than the contraceptive effect. Long-term clinical studies have shown that patients taking combined tablet contraceptives were much less likely to encounter not only gynecological, but also general somatic problems. In the course of improving the quantitative and qualitative composition of these drugs, an effective regimen was found, called prolonged, when the drug is taken continuously, without the traditional weekly interval. At the same time, it is possible to achieve not only the prevention of unplanned pregnancy, but also reduce the risk of developing many diseases. One of the drugs suitable for use in this regimen is Regulon, a combination of ethinyl estradiol and desogestrel (III generation progestogen). Even a relatively small amount of desogestrel is more than enough to suppress ovulation (60 mcg of the substance per day suppresses ovulation by 100%). Back in the late 90s of the last century, it was noted that etonogestrel, an active metabolite of desogestrel, has extremely high affinity for progesterone receptors, has high progestogenic activity and exhibits a powerful antigonadotropic effect.

One Regulon tablet includes 150 mcg of desogestrel, i.e. 2.5 times more of it than is necessary to completely suppress ovulation. Another component of the contraceptive action of the drug is its ability to inhibit the formation of gonadotropins. In addition to this, due to the change in the rheological properties of the mucus, the progression of spermatozoa along the cervical canal slows down, and the change in the thickness and structure of the endometrium does not allow the fertilized egg to be implanted on its mucosa. The second component of the drug - ethinylestradiol - is an artificial analogue of the female sex hormone estradiol produced in the body. Regulon improves the lipid profile, which is manifested in an increase in the concentration of high-density lipoproteins ("good" cholesterol) while the content of low-density lipoproteins ("bad" cholesterol) remains unchanged. Taking the drug can significantly reduce blood loss during menstruation (with existing menorrhagia), improve skin condition, and prevent acne. Before using Regulon, it is necessary to undergo an in-depth medical examination (history taking, blood pressure measurement, laboratory tests, gynecological examination). Such medical monitoring should be carried out during the period of use of the drug every six months.

Pharmacology

Monophasic oral contraceptive. The main contraceptive action is to inhibit the synthesis of gonadotropins and suppress ovulation. In addition, by increasing the viscosity of cervical mucus, the movement of spermatozoa through the cervical canal slows down, and a change in the state of the endometrium prevents the implantation of a fertilized egg.

Ethinyl estradiol is a synthetic analogue of endogenous estradiol.

Desogestrel has a pronounced gestagenic and antiestrogenic effect, similar to endogenous progesterone, weak androgenic and anabolic activity.

Regulon has a beneficial effect on lipid metabolism: it increases the concentration of HDL in the blood plasma, without affecting the content of LDL.

When taking the drug, the loss of menstrual blood is significantly reduced (with initial menorrhagia), the menstrual cycle is normalized, and a beneficial effect on the skin is noted, especially in the presence of acne vulgaris.

Pharmacokinetics

Desogestrel

Suction

Desogestrel is quickly and almost completely absorbed from the gastrointestinal tract and is immediately metabolized into 3-keto-desogestrel, which is a biologically active metabolite of desogestrel.

Cmax is reached after 1.5 hours and is 2 ng/ml. Bioavailability - 62-81%.

Distribution

3-keto-desogestrel binds to plasma proteins, mainly albumin and sex hormone binding globulin (SHBG). V d is 1.5 l/kg. C ss is established by the second half of the menstrual cycle. The level of 3-keto-desogestrel increases 2-3 times.

Metabolism

In addition to 3-keto-desogestrel (which is formed in the liver and in the intestinal wall), other metabolites are formed: 3α-OH-desogestrel, 3β-OH-desogestrel, 3α-OH-5α-H-desogestrel (first phase metabolites). These metabolites do not have pharmacological activity and are partially converted, through conjugation (the second phase of metabolism), into polar metabolites - sulfates and glucuronates. Clearance from blood plasma is about 2 ml/min/kg body weight.

breeding

T1/2 of 3-keto-desogestrel is 30 hours. Metabolites are excreted in the urine and feces (in a ratio of 4:6).

Ethinyl estradiol

Suction

Ethinyl estradiol is quickly and completely absorbed from the gastrointestinal tract. Cmax is achieved 1-2 hours after taking the drug and is 80 pg/ml. The bioavailability of the drug due to presystemic conjugation and the “first pass” effect through the liver is about 60%.

Distribution

Ethinyl estradiol is completely bound to plasma proteins, mainly albumin. Vd is 5 l/kg. C ss is established by the 3-4th day of administration, while the level of ethinyl estradiol in the serum is 30-40% higher than after a single dose of the drug.

Metabolism

Presystemic conjugation of ethinyl estradiol is significant. Bypassing the intestinal wall (first phase of metabolism), it undergoes conjugation in the liver (second phase of metabolism). Ethinyl estradiol and its conjugates of the first phase of metabolism (sulfates and glucuronides) are excreted into bile and enter the enterohepatic circulation. Clearance from blood plasma is about 5 ml/min/kg body weight.

breeding

T1/2 of ethinyl estradiol averages about 24 hours. About 40% is excreted in the urine and about 60% in feces.

Release form

White or almost white, film-coated tablets, round, biconvex, marked “P8” on one side and “RG” on the other.

Excipients: α-tocopherol, magnesium stearate, colloidal silicon dioxide, stearic acid, povidone, potato starch, lactose monohydrate.

Film shell composition: propylene glycol, macrogol 6000, hypromellose.

21 pcs. - blisters (1) - cardboard packs.
21 pcs. - blisters (3) - packs of cardboard.

Dosage

The drug is prescribed orally.

Taking pills starts on the 1st day of the menstrual cycle. Assign 1 tablet / day for 21 days, if possible at the same time of day. After taking the last tablet from the package, take a 7-day break, during which menstrual-like bleeding occurs due to drug withdrawal. The next day after a 7-day break (4 weeks after taking the first tablet, on the same day of the week), resume taking the drug from the next package, also containing 21 tablets, even if the bleeding has not stopped. This pill regimen is followed as long as there is a need for contraception. If you follow the rules of administration, the contraceptive effect remains during the 7-day break.

First dose of the drug

The first tablet should be taken on the first day of the menstrual cycle. In this case, it is not necessary to use additional methods of contraception. You can start taking pills from the 2-5th day of menstruation, but in this case, in the first cycle of using the drug, you must use additional methods of contraception in the first 7 days of taking the pills.

If more than 5 days have passed since the start of menstruation, you should delay starting the drug until your next menstruation.

Taking the drug after childbirth

Women who are not breastfeeding can start taking the pill no earlier than 21 days after giving birth, after consulting with their doctor. In this case, there is no need to use other methods of contraception. If there has already been sexual contact after childbirth, then taking the pills should be postponed until the first menstruation. If a decision is made to take the drug later than 21 days after birth, then additional methods of contraception must be used in the first 7 days.

Taking the drug after an abortion

After an abortion, in the absence of contraindications, you should start taking pills from the first day after surgery, and in this case there is no need to use additional methods of contraception.

Switching from another oral contraceptive

When switching from another oral drug (21- or 28-day): it is recommended to take the first Regulon tablet the day after completing the course of the 28-day package of the drug. After completing the 21-day course, you must take the usual 7-day break and then start taking Regulon. There is no need to use additional methods of contraception.

Switching to Regulon after using oral hormonal drugs containing only progestogen ("mini-pills")

The first Regulon tablet should be taken on the 1st day of the cycle. There is no need to use additional methods of contraception.

If menstruation does not occur while taking the mini-pill, then after excluding pregnancy, you can start taking Regulon on any day of the cycle, but in this case, in the first 7 days it is necessary to use additional methods of contraception (using a cervical cap with spermicidal gel, a condom, or abstinence from sexual intercourse). The use of the calendar method in these cases is not recommended.

Delay of the menstrual cycle

If there is a need to delay menstruation, you must continue taking the tablets from the new package, without a 7-day break, according to the usual regimen. When menstruation is delayed, breakthrough or spotting bleeding may occur, but this does not reduce the contraceptive effect of the drug. Regular use of Regulon can be resumed after the usual 7-day break.

Missed pills

If a woman forgot to take a pill on time, and no more than 12 hours have passed since the omission, she needs to take the forgotten pill, and then continue taking it at the usual time. If more than 12 hours have passed between taking pills, this is considered a missed pill; the reliability of contraception in this cycle is not guaranteed and the use of additional methods of contraception is recommended.

If you miss one tablet in the first or second week of the cycle, you need to take 2 tablets. the next day and then continue regular use using additional methods of contraception until the end of the cycle.

If you miss a pill in the third week of the cycle, you should take the forgotten pill, continue taking it regularly and not take a 7-day break. It is important to remember that due to the minimum dose of estrogen, the risk of ovulation and/or spotting increases if you miss a pill and therefore the use of additional methods of contraception is recommended.

Vomiting/diarrhea

If vomiting or diarrhea occurs after taking the drug, then absorption of the drug may be inadequate. If the symptoms stop within 12 hours, then you need to take one more tablet. After this, you should continue taking the tablets as usual. If vomiting or diarrhea continues for more than 12 hours, then it is necessary to use additional methods of contraception during vomiting or diarrhea and for the next 7 days.

Overdose

Symptoms: nausea, vomiting, in girls - bleeding from the vagina.

Treatment: in the first 2-3 hours after taking the drug in a high dose, gastric lavage is recommended. There is no specific antidote, treatment is symptomatic.

Interaction

Drugs that induce liver enzymes, such as hydantoin, barbiturates, primidone, carbamazepine, rifampicin, oxcarbazepine, topiramate, felbamate, griseofulvin, St. John's wort, reduce the effectiveness of oral contraceptives and increase the risk of breakthrough bleeding. The maximum level of induction is usually reached no earlier than 2-3 weeks, but may last up to 4 weeks after discontinuation of the drug.

Ampicillin and tetracycline reduce the effectiveness of Regulon (the mechanism of interaction has not been established). If co-administration is necessary, it is recommended to use an additional barrier method of contraception throughout the entire course of treatment and for 7 days (for rifampicin - within 28 days) after discontinuation of the drug.

Oral contraceptives may decrease carbohydrate tolerance and increase the need for insulin or oral antidiabetic agents.

Side effects

Side effects requiring discontinuation of the drug

From the cardiovascular system: arterial hypertension; rarely - arterial and venous thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism); very rarely - arterial or venous thromboembolism of the hepatic, mesenteric, renal, retinal arteries and veins.

From the senses: hearing loss caused by otosclerosis.

Other: hemolytic-uremic syndrome, porphyria; rarely - exacerbation of reactive systemic lupus erythematosus; very rarely - Sydenham's chorea (passing after discontinuation of the drug).

Other side effects that are more common but less severe. The advisability of continuing to use the drug is decided individually after consultation with a doctor, based on the benefit/risk ratio.

From the reproductive system: acyclic bleeding/bloody discharge from the vagina, amenorrhea after discontinuation of the drug, changes in the state of vaginal mucus, the development of inflammatory processes in the vagina, candidiasis, tension, pain, enlarged mammary glands, galactorrhea.

From the digestive system: nausea, vomiting, Crohn's disease, ulcerative colitis, the occurrence or exacerbation of jaundice and/or itching associated with cholestasis, cholelithiasis.

Dermatological reactions: erythema nodosum, exudative erythema, rash, chloasma.

From the central nervous system: headache, migraine, mood lability, depression.

On the part of the organ of vision: increased sensitivity of the cornea (when wearing contact lenses).

Metabolism: fluid retention in the body, change (increase) in body weight, decreased tolerance to carbohydrates.

Other: allergic reactions.

Indications

Contraception.

Contraindications

• the presence of severe and/or multiple risk factors for venous or arterial thrombosis (including severe or moderate arterial hypertension with blood pressure ≥ 160/100 mm Hg);
• presence or indication in history of precursors of thrombosis (including transient ischemic attack, angina pectoris);
• migraine with focal neurological symptoms, incl. in the anamnesis;
• venous or arterial thrombosis/thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the leg, pulmonary embolism) currently or in history;
• a history of venous thromboembolism;
• diabetes mellitus (with angiopathy);
• pancreatitis (including a history), accompanied by severe hypertriglyceridemia;
• dyslipidemia;
• severe liver diseases, cholestatic jaundice (including during pregnancy), hepatitis, incl. history (before normalization of functional and laboratory parameters and within 3 months after their normalization);
• jaundice when taking GCS;
• gallstone disease currently or in history;
• Gilbert's syndrome, Dubin-Johnson syndrome, Rotor syndrome;
• liver tumors (including history);
• severe itching, otosclerosis or its progression during a previous pregnancy or taking corticosteroids;
• hormone-dependent malignant neoplasms of the genital organs and mammary glands (including if they are suspected);
• vaginal bleeding of unknown etiology;
• smoking over the age of 35 (more than 15 cigarettes per day);
• pregnancy or suspicion of it;
• lactation period;
• hypersensitivity to the components of the drug.

The drug should be prescribed with caution in conditions that increase the risk of developing venous or arterial thrombosis/thromboembolism: age over 35 years, smoking, family history, obesity (body mass index more than 30 kg/m2), dyslipoproteinemia, arterial hypertension, migraine, epilepsy, valvular heart defects, atrial fibrillation, prolonged immobilization, extensive surgery, surgery on the lower extremities, severe trauma, varicose veins and superficial thrombophlebitis, the postpartum period, the presence of severe depression (including a history), changes in biochemical parameters ( activated protein C resistance, hyperhomocysteinemia, antithrombin III deficiency, protein C or S deficiency, antiphospholipid antibodies, including antibodies to cardiolipin, including lupus anticoagulant), diabetes mellitus not complicated by vascular disorders, SLE, Crohn's disease , ulcerative colitis, sickle cell anemia, hypertriglyceridemia (incl. family history), acute and chronic liver diseases.

Application features

Use during pregnancy and breastfeeding

The use of the drug during pregnancy and breastfeeding is contraindicated.

During breastfeeding, it is necessary to resolve the issue of either discontinuing the drug or stopping breastfeeding.

Use for liver dysfunction

Contraindicated in liver failure.

The drug should be prescribed with caution for acute and chronic liver diseases.

Use for renal impairment

With caution and only after a thorough assessment of the benefits and risks of use, the drug should be prescribed for renal failure (including a history).

special instructions

Before starting to use the drug, it is necessary to conduct a general medical examination (detailed family and personal history, blood pressure measurement, laboratory tests) and gynecological examination (including examination of the mammary glands, pelvic organs, cytological analysis of a cervical smear). Such examinations during the period of taking the drug are carried out regularly, every 6 months.

The drug is a reliable contraceptive: the Pearl index (an indicator of the number of pregnancies occurring during the use of a contraceptive method in 100 women over 1 year) when used correctly is about 0.05.

In each case, before prescribing hormonal contraceptives, the benefits or possible negative effects of their use are individually assessed. This issue must be discussed with the patient, who, after receiving the necessary information, will make the final decision on the preference for hormonal or any other method of contraception.

The woman's health condition must be carefully monitored. If any of the following conditions/diseases appear or worsen while taking the drug, you must stop taking the drug and switch to another, non-hormonal method of contraception:

• diseases of the hemostatic system;
• conditions/diseases predisposing to the development of cardiovascular and renal failure;
• epilepsy;
• migraine;
• the risk of developing an estrogen-dependent tumor or estrogen-dependent gynecological diseases;
• diabetes mellitus not complicated by vascular disorders;
• severe depression (if depression is associated with a violation of tryptophan metabolism, then vitamin B 6 can be used for correction);
• sickle cell anemia, because in some cases (for example, infections, hypoxia), estrogen-containing drugs for this pathology can provoke thromboembolism;
• the appearance of abnormalities in laboratory tests assessing liver function.

Thromboembolic diseases

Epidemiological studies have shown that there is a connection between taking oral hormonal contraceptives and an increased risk of developing arterial and venous thromboembolic diseases (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism). An increased risk of venous thromboembolic diseases has been proven, but it is significantly less than during pregnancy (60 cases per 100 thousand pregnancies).

Some researchers suggest that the likelihood of venous thromboembolic disease is greater with drugs containing desogestrel and gestodene (third generation drugs) than with drugs containing levonorgestrel (second generation drugs).

The incidence of spontaneous occurrence of new cases of venous thromboembolic disease in healthy non-pregnant women not taking oral contraceptives is about 5 cases per 100 thousand women per year. When using second generation drugs - 15 cases per 100 thousand women per year, and when using third generation drugs - 25 cases per 100 thousand women per year.

When using oral contraceptives, arterial or venous thromboembolism of the hepatic, mesenteric, renal or retinal vessels is very rarely observed.

The risk of arterial or venous thromboembolic disease increases:

• with age;
• when smoking (heavy smoking and age over 35 years are risk factors);
• if there is a family history of thromboembolic diseases (for example, parents, brother or sister). If a genetic predisposition is suspected, it is necessary to consult a specialist before using the drug;
• for obesity (body mass index more than 30 kg/m2);
• with dislipoproteinemia;
• with arterial hypertension;
• for diseases of the heart valves complicated by hemodynamic disorders;
• with atrial fibrillation;
• with diabetes mellitus complicated by vascular lesions;
• with prolonged immobilization, after major surgery, after surgery on the lower extremities, after severe trauma.

In these cases, it is assumed to temporarily stop using the drug (no later than 4 weeks before surgery, and resume no earlier than 2 weeks after remobilization).

Women after childbirth have an increased risk of venous thromboembolic disease.

It should be taken into account that diabetes mellitus, systemic lupus erythematosus, hemolytic-uremic syndrome, Crohn's disease, ulcerative colitis, sickle cell anemia increase the risk of developing venous thromboembolic diseases.

It should be taken into account that resistance to activated protein C, hyperhomocysteinemia, protein C and S deficiency, antithrombin III deficiency, and the presence of antiphospholipid antibodies increase the risk of developing arterial or venous thromboembolic diseases.

When assessing the benefit/risk ratio of taking the drug, it should be taken into account that targeted treatment of this condition reduces the risk of thromboembolism. Symptoms of thromboembolism are:

• sudden chest pain that radiates to the left arm;
• sudden shortness of breath;
• any unusually severe headache that continues for a long time or appears for the first time, especially when combined with sudden complete or partial loss of vision or diplopia, aphasia, dizziness, collapse, focal epilepsy, weakness or severe numbness of half the body, movement disorders, severe unilateral pain in the calf muscle, sharp abdomen.

Tumor diseases

Some studies have reported an increased incidence of cervical cancer in women who took hormonal contraceptives for a long time, but the results of the studies are inconsistent. Sexual behavior, infection with the human papillomavirus and other factors play a significant role in the development of cervical cancer.

A meta-analysis of 54 epidemiological studies found that there was a relative increase in the risk of breast cancer among women taking oral hormonal contraceptives, but the higher detection rate of breast cancer may have been associated with more regular medical screening. Breast cancer is rare among women under 40, whether they are taking hormonal birth control or not, and increases with age. Taking pills can be considered one of many risk factors. However, the woman should be made aware of the possible risk of developing breast cancer based on an assessment of the benefit-risk ratio (protection against ovarian and endometrial cancer).

There are few reports of the development of benign or malignant liver tumors in women taking hormonal contraceptives for a long time. This should be kept in mind when differentially assessing abdominal pain, which may be associated with an increase in liver size or intraperitoneal bleeding.

Chloasma can develop in women with a history of this disease during pregnancy. Those women who are at risk of developing chloasma should avoid contact with sunlight or ultraviolet radiation while taking Regulon.

Efficiency

The effectiveness of the drug may be reduced in the following cases: missed pills, vomiting and diarrhea, simultaneous use of other drugs that reduce the effectiveness of birth control pills.

If the patient is simultaneously taking another drug that may reduce the effectiveness of birth control pills, additional methods of contraception should be used.

The effectiveness of the drug may decrease if, after several months of their use, irregular, spotting or breakthrough bleeding appears, in such cases it is advisable to continue taking the tablets until they run out in the next package. If at the end of the second cycle menstrual-like bleeding does not begin or acyclic bleeding does not stop, stop taking the pills and resume it only after pregnancy has been ruled out.

Changes in laboratory parameters

Under the influence of oral contraceptive pills - due to the estrogen component - the level of some laboratory parameters (functional indicators of the liver, kidneys, adrenal glands, thyroid gland, hemostasis indicators, levels of lipoproteins and transport proteins) may change.

Additional Information

After acute viral hepatitis, the drug should be taken after normalization of liver function (no earlier than 6 months).

With diarrhea or intestinal disorders, vomiting, the contraceptive effect may be reduced. While continuing to take the drug, it is necessary to use additional non-hormonal methods of contraception.

Women who smoke have an increased risk of developing vascular diseases with serious consequences (myocardial infarction, stroke). The risk depends on age (especially in women over 35 years of age) and on the number of cigarettes smoked.

The woman should be warned that the drug does not protect against HIV infection (AIDS) and other sexually transmitted diseases.

Impact on the ability to drive vehicles and operate machinery

The drug does not affect the ability to drive a car or operate machinery.

Nowadays, despite the huge selection of contraceptive drugs, Regulon is rightfully considered the best of them. It contains a combination of estrogen and progestogen, and these synthetic substances are much more active than natural sex hormones. The principle of action of the drug is to prevent the release of hormones and this interferes with the ovulation process, in addition, it significantly impedes the penetration of sperm into the uterine cavity.

It is very interesting to learn about Regulon specialists. In their opinion, the same processes occur in the body of women using this product as during the first weeks of pregnancy. That is, this drug, when taken regularly over several years, recreates what nature itself would do if a woman decided to have children every year. By the way, frequent birth of children is today the most reliable method for preventing cancer of the genital organs and mammary glands.

These data completely refute the talk that Regulon, the use of which is so widespread today, must be taken at intervals of several months. In fact, no breaks in taking are absolutely necessary. On the contrary, doctors believe that if you take breaks between cycles of using Regulon or others, this can only harm the female body. When discussing the question of how to take it correctly, they clearly say that the more time a woman regularly uses this drug, the stronger its therapeutic effect.

It is recommended to start using such drugs as soon as sexual activity begins and use them as long as there is a need to take contraceptives. This is also evidenced by existing statistics, because among patients who have never taken such drugs, the percentage of women with infertility is much higher than among those who regularly use hormonal drugs. When Regulon is used for a long time, the best conditions for the development and maturation of eggs are created in the female body.

Among women who regularly use Regulon, reviews of the side effects of its use are more inclined to worry about weight gain. However, it has been established that this drug does not affect the metabolism in the body at all and therefore its use does not contribute to excess weight gain. In general, any side effects may occur extremely rarely. Usually this is vomiting or nausea, bad mood, tension in the mammary glands. These effects are very short in duration and disappear without a trace after 2-3 months of regular use of the drug.

Among patients taking Regulon for a long time, there are practically no reviews of negative side effects. In exceptional cases, pigment spots on the skin or an increase in blood pressure may appear. Although the risk of any side effects increases significantly if you start using hormonal drugs without a doctor’s recommendation. In such cases, if severe side effects are detected: for example, abnormally severe headaches, a sharp drop in vision, or a sudden sharp increase in blood pressure, urgent withdrawal of Regulon is necessary and you should immediately consult a doctor. He will tell you how best to use the drug and check contraindications to its use. Regulon has proven itself very well in the treatment of various menstrual disorders and is the most reliable means of preventing pregnancy.

Around the world, about 50% of women of reproductive age are protected from unwanted pregnancy by combined oral contraceptives. Regulon is one of the representatives of this group of contraceptives. The question arises: why do Russian women flatly refuse to take hormonal pills, including Regulon?

Many people believe that Regulon and other hormonal contraceptives have a negative effect on weight, that is, they increase it. But regulon (like other oral contraceptives) and weight, subject to the rules of administration, daily routine and nutrition, are absolutely indifferent to each other. Therefore, if your doctor has prescribed Regulon, you should not be afraid of gaining weight, you just need to follow his recommendations.

Historical reference

The first oral combined contraceptives appeared in 1960. The pill, called Enovid, was hailed as a revolution in contraception. They really reliably protected against unwanted pregnancy, but they also had a lot of disadvantages. The latter included: nausea and vomiting, engorgement and tenderness of the mammary glands, a pronounced increase in body weight (due to fluid retention in the body) and an increase in the blood coagulation system. Later, newer drugs appeared, such as bisecurin, ovulen, anovlar and others, but they also had a lot of disadvantages. Such effects are explained by the high content of hormones in the tablets. Over the past 40 years, hormonal pills have undergone significant changes not only in the quantitative content of hormones, but also in their type. Ethinide estradiol doses were reduced from 150 to 35 mcg. In modern combined oral contraceptives, the standard dose of ethinyl estradiol is 30 or 35 mcg, the newest drugs contain 20 mcg of ethinyl estradiol.

A little about the regulon

Regulon is a monophasic oral contraceptive containing 30 mcg ethinyl estradiol and 150 mcg desogestrel. Desogestrel is a synthetic gestagen. It inhibits the formation of luteinizing and follicle-stimulating hormones in the pituitary gland, thereby preventing follicle maturation, which leads to suppression of ovulation . Ethinyl estradiol is a synthetic analogue of estradiol and interferes with the maturation of the egg, which is necessary for fertilization. Taking Regulon is not indicated in the postpartum period, as this leads to a decrease in the amount of milk, reduces lactation and affects the growth of the child. Therefore, regulon is prescribed to women only after stopping breastfeeding.

Why does weight increase when taking Regulon?

Many women, not understanding the cause and effect of weight gain, blame the “ill-fated” Regulon pills for this and flatly refuse to take them. And only a small percentage of women consider it necessary to see a doctor to clarify the situation with weight gain. Undoubtedly, while taking Regulon, weight may increase, and its increase depends on three mechanisms:

• Fluid retention in the body

An analogue of the hormone progesterone contained in the regulon, desogestrel, promotes slight fluid retention in the body. Precisely with progesterone , for example, the appearance of edema during pregnancy is associated.

• Appetite increase

Sex hormones contained in regulon accelerate the biochemical reactions of fats and carbohydrates. With sufficient physical activity, excess calories are easily converted into heat, and when leading a passive lifestyle, they are deposited in the form of additional kilograms.

• Decreased thyroid function

How to deal with excess weight?

From the above, it becomes clear that Regulon tablets are not to blame for weight gain. To keep your weight the same while taking Regulon, you must follow a few simple rules:

• Control the amount of food consumed

This rule must be observed especially in the first months of taking Regulon. That is, if a woman previously ate one bowl of soup for lunch, then in the future she should stick to the same “dose.” Avoid snacking, especially before