Eufillin in injections instructions for use. "Eufillin": instructions for use in ampoules, indications and reviews

Aminophylline (aminophylline)

Composition and form of release of the drug

Solution for intravenous administration in the form of a colorless or slightly colored transparent liquid.

Excipients: water for injection - up to 1 ml.

5 ml - ampoules (5) - packs of cardboard.
5 ml - ampoules (10) - packs of cardboard.
10 ml - ampoules (5) - packs of cardboard.
10 ml - ampoules (10) - packs of cardboard.

pharmachologic effect

Bronchodilator, PDE inhibitor. It is an ethylenediamine salt (which facilitates solubility and increases absorption). It has a bronchodilatory effect, apparently due to a direct relaxing effect on the smooth muscles of the respiratory tract and blood vessels of the lungs. It is believed that this action is caused by selective suppression of the activity of specific PDEs, which leads to an increase in the intracellular concentration of cAMP. The results of experimental studies in vitro show that the main role, apparently, is played by type III and IV isoenzymes. Suppression of the activity of these isoenzymes can also cause some side effects of aminophylline (theophylline), incl. vomiting, arterial hypotension and tachycardia. It blocks adenosine (purine) receptors, which may be one of the factors affecting the bronchi.

Reduces airway hyperresponsiveness associated with the late phase of the inhalation response through an unknown mechanism that is not related to PDE inhibition or blockade of the action of adenosine. There are reports that aminophylline increases the number and activity of T-suppressors in the peripheral blood.

Increases mucociliary clearance, stimulates diaphragm contraction, improves the function of the respiratory and intercostal muscles, stimulates the respiratory center, increases its sensitivity to carbon dioxide and improves alveolar ventilation, which ultimately leads to a decrease in the severity and frequency of apnea episodes. By normalizing the respiratory function, it helps to saturate the blood with oxygen and reduce the concentration of carbon dioxide. Enhances lung ventilation in conditions of hypokalemia.

It has a stimulating effect on the activity of the heart, increases strength and heart rate, increases coronary blood flow and increases myocardial oxygen demand. Reduces the tone of blood vessels (mainly the vessels of the brain, skin and kidneys). It has a peripheral venodilating effect, reduces pulmonary vascular resistance, lowers pressure in the pulmonary circulation. Increases renal blood flow, has a moderate diuretic effect. Expands the extrahepatic bile ducts. Stabilizes mast cell membranes, inhibits the release of mediators of allergic reactions. It inhibits platelet aggregation (suppresses the platelet activating factor and PgE 2α), increases the resistance of erythrocytes to deformation (improves the rheological properties of blood), reduces thrombosis and normalizes microcirculation. It has a tocolytic effect, increases the acidity of gastric juice. In high doses, it has an epileptogenic effect.

Pharmacokinetics

In the body, aminophylline is metabolized at physiological pH to release free theophylline. Bronchodilating properties are manifested at concentrations of theophylline in the blood of 10-20 μg / ml. Concentration over 20 mg/ml is toxic. The excitatory effect on the respiratory center is realized at a lower concentration - 5-10 µg/ml.

The binding of theophylline to plasma proteins is approximately 40%; in newborns, as well as in adults with diseases, the binding is reduced. Plasma protein binding in adults is about 60%, in newborns - 36%, in patients with liver cirrhosis - 36%. Penetrates through the placental barrier (the concentration in the serum of the fetus is slightly higher than in the mother's serum). It is allocated with breast milk.

Theophylline is metabolized in the liver by several cytochrome P450 isoenzymes, the most important of which is CYP1A2. In the process of metabolism, 1,3-dimethyluric acid, 1-methyluric acid and 3-methylxanthine are formed. These metabolites are excreted in the urine. In unchanged form, 10% is excreted in adults. In newborns, a significant part is excreted in the form of caffeine (due to the immaturity of the pathways for its further metabolism), unchanged - 50%.

Significant individual differences in the rate of hepatic metabolism of theophylline are the cause of pronounced variability in clearance values, plasma concentrations, and half-life. Hepatic metabolism is influenced by factors such as age, addiction to tobacco smoking, diet, diseases, and concomitant drug therapy.

T 1/2 of theophylline in non-smoking patients with bronchial asthma with virtually no pathological changes in other organs and systems is 6-12 hours, in smokers - 4-5 hours, in children - 1-5 hours, in newborns and premature babies - 10 -45 h.

T 1/2 of theophylline increases in the elderly and in patients with heart failure or liver disease.

Clearance decreases with heart failure, liver dysfunction, chronic alcoholism, pulmonary edema, COPD.

Ethylenediamine does not affect the pharmacokinetics of theophylline.

Indications

For parenteral use: status asthmaticus (adjunctive therapy), neonatal apnea, ischemic cerebrovascular accident (as part of combination therapy), left ventricular failure with bronchospasm and respiratory failure of the Cheyne-Stokes type, edematous syndrome of renal genesis (as part of complex therapy) ; acute and chronic insufficiency (as part of combination therapy).

For oral administration: broncho-obstructive syndrome of various origins (including bronchial asthma, COPD, including pulmonary emphysema, chronic obstructive bronchitis), hypertension in the pulmonary circulation, cor pulmonale, sleep apnea; acute and chronic heart failure (as part of combination therapy).

Contraindications

Severe arterial hyper- or hypotension, tachyarrhythmias, peptic ulcer of the stomach and duodenum in the acute phase, hyperacid gastritis, severe liver and / or kidney dysfunction, epilepsy, hemorrhagic stroke, retinal hemorrhage, simultaneous use with children, children's age ( up to 3 years, for prolonged oral forms - up to 12 years), hypersensitivity to aminophylline and theophylline.

Dosage

Individual, depending on the indications, age, clinical situation, route and scheme of administration, nicotine addiction.

Side effects

From the nervous system: dizziness, sleep disturbances, anxiety, tremor, convulsions.

From the side of the cardiovascular system: palpitations, heart rhythm disturbances; with rapid on / in the introduction - the appearance of pain in the heart, a decrease in blood pressure, tachycardia (including in the fetus when taken in the third trimester of pregnancy), arrhythmias, a decrease in blood pressure, cardialgia, an increase in the frequency of angina attacks.

From the digestive system: nausea, vomiting, gastroesophageal reflux, heartburn, exacerbation of peptic ulcer, diarrhea; with prolonged ingestion - anorexia.

From the urinary system: albuminuria, hematuria.

Allergic reactions: skin rash, itching, fever.

From the side of metabolism: rarely - hypoglycemia.

Local reactions: compaction, hyperemia, soreness at the injection site; with rectal application, irritation of the mucous membrane of the rectum, proctitis.

Others: chest pain, tachypnea, flushing, albuminuria, hematuria, hypoglycemia, increased diuresis, increased sweating.

drug interaction

With simultaneous use with sympathomimetics, there is a mutual enhancement of action; with and preparations of lithium - the effect is mutually reduced. The intensity of the action of aminophylline may decrease (due to an increase in its clearance) when used simultaneously with phenobarbital, rifampicin, carbamazepine, sulfinpyrazone, phenytoin, and also in smokers.

The intensity of the action of aminophylline may increase (due to a decrease in its clearance) when used simultaneously with macrolide antibiotics, lincomycin, quinolones, allopurinol, beta-blockers, cimetidine, disulfiram, fluvoxamine, hormonal contraceptives for oral administration, isoprenaline, viloxazine and vaccination against flu.

Xanthine derivatives can potentiate hypokalemia due to the action of β2-adrenergic stimulants, corticosteroids, and diuretics.

Antidiarrheal drugs and enterosorbents reduce the absorption of aminophylline.

Pharmaceutically incompatible with acid solutions.

special instructions

Use with caution in severe coronary insufficiency (acute phase of myocardial infarction, angina pectoris), widespread atherosclerosis, hypertrophic obstructive cardiomyopathy, frequent ventricular extrasystole, increased convulsive readiness, with liver and / or kidney failure, gastric ulcer and duodenal ulcer (in history), with recent bleeding from the gastrointestinal tract, uncontrolled hypothyroidism (the possibility of cumulation) or thyrotoxicosis, with prolonged hyperthermia, gastroesophageal reflux, prostatic hypertrophy, in elderly patients, in children (especially inside).

Correction of the dosage regimen of aminophylline may be required for heart failure, impaired liver function, chronic alcoholism, fever, acute respiratory infections.

In elderly patients, a dose reduction may be required.

When replacing the used dosage form of aminophylline with another, clinical observation and monitoring of theophylline concentration in blood plasma is necessary.

Aminophylline is not used simultaneously with other xanthine derivatives. During the period of treatment, the use of foods containing xanthine derivatives (strong coffee, tea) should be avoided.

Use with caution simultaneously with anticoagulants, with other derivatives of theophylline or purine.

Simultaneous use with beta-blockers should be avoided.

Aminophylline should not be used simultaneously with glucose solution.

Do not use rectally in children.

Pregnancy and lactation

Theophylline crosses the placental barrier. The use of aminophylline during pregnancy can lead to the creation of potentially dangerous concentrations of theophylline and caffeine in the blood plasma of the newborn. Newborns whose mothers received aminophylline during pregnancy (especially in the third trimester) require medical supervision to control possible symptoms of theophylline intoxication.

Theophylline is excreted in breast milk. When using aminophylline in a nursing mother during lactation, irritability may occur in a child.

Thus, the use of aminophylline during pregnancy and lactation (breastfeeding) is possible in cases where the intended benefit of therapy for the mother outweighs the potential risk to the fetus or child.

Use in the elderly

With caution: elderly patients (dose reduction may be required).

Eufillin, instructions for use in ampoules (intravenously) of which is present in each package, belongs to the category of bronchodilators. The use of the solution is carried out parenterally (drip, jet, intramuscular). Eufillin (shots) is prescribed for adults, tablets are more suitable for children.

Eufillin is a solution for intravenous administration, which is a colorless transparent liquid poured into glass ampoules. The active ingredient is aminophylline, its concentration does not exceed 24 mg / ml. Distilled water acts as an additive. Ampoules are packaged in cardboard boxes (5 pcs each). Produced in the Russian Federation, the Republic of Belarus and Ukraine.

pharmachologic effect

Eufillin (intravenously and for intramuscular administration) has a diuretic, antispasmodic, tocolytic and bronchodilatory effect on the body. The solution for injection helps with pathologies accompanied by obstruction (obstruction) of the respiratory tract. Eufillin intramuscular can be considered a medicine for systemic use.

The principle of action of Eufillin in ampoules is based on the ability of the drug to block the adenosine (purine) receptors of bronchial cells and accelerate the accumulation of cyclic adenosine monophosphate in them. With regular use, there is a decrease in the rate of entry of calcium ions through the channels of cell membranes and a decrease in muscle contractile activity.

Therapeutic effect of Eufillin:

• improvement of alveolar ventilation;
• stimulation of breathing;
• increased sensitivity of the respiratory center;
• improving the activity of the respiratory and intercostal muscles;
• increase in mucociliary coefficient;
• stimulation of diaphragm contractions;
• bronchial relaxation.

The drug can be used for sleep apnea: the drug normalizes breathing, provides an influx of oxygen and reduces the concentration of carbon dioxide. The drug is able to stimulate the activity of the heart muscle, normalizing the frequency of its contractions. Accelerates blood microcirculation, reduces the tension of the walls of blood vessels.

Diuretic properties are manifested in the form of an increase in the volume of blood flow in the kidneys. Eufillin in ampoules expands the bile ducts, improves the rheological properties of blood and minimizes the risk of blood clots. The tocolytic effect is manifested in the form of a decrease in contractility and excitability of the myometrium. When using Eufillin in high doses, an epileptogenic effect is observed.

When it enters the systemic circulation, the active ingredient is 60% bound to plasma proteins. Metabolism is carried out by the liver. The half-life is 3-6 hours. Excreted by the kidneys or intestines (partially).

Indications and contraindications for use

In the instructions present in each box of Euphyllin, possible contraindications and indications for use are prescribed. The drug is prescribed for the following pathologies:

• left ventricular failure (bronchospasm, Cheyne-Stokes breathing);
• prolonged migraines;
• hypertension of the pulmonary circle;
• cerebrovascular insufficiency of the brain;
• broncho-obstructive syndrome with emphysema, cardiac asthma or bronchitis.

The main contraindications are:

• severe liver and kidney disease;
• sepsis;
• porphyria;
• hyperthyroidism;
• thyrotoxicosis;
• hypothyroidism of uncontrolled type;
• gastroesophageal reflux;
• increased threshold of convulsive readiness;
• epileptic seizures;
• ulcerative lesions of the stomach and duodenum (in the acute stage);
• hemorrhages in the retina;
• bleeding (gastric, intestinal in anamnesis);
• hemorrhagic stroke;
• vascular atherosclerosis;
• pulmonary edema;
• severe arterial hypertension;
• paroxysmal hypotension;
• tachycardia;
• extrasystole;
• angina;
• myocardial infarction;
• acute heart failure;
• individual intolerance to the active ingredient or additional substances.

The high risk of side effects makes it impossible to use Eufillin in children under the age of 14 years. Lactation and pregnancy are considered relative contraindications. Children under 3 years of age do not inject the solution into a vein. Droppers with Euphyllin for osteochondrosis dilate blood vessels, helping to stop a pain attack. Regardless of the form of release, the drug can be taken with bronchial asthma.

Eufillin during pregnancy

Eufillin is prescribed for women in a position for health reasons in the absence of a threat to the life of the mother and child. According to reviews, a pregnant woman's heart rate increases, dizziness and weakness appear.

Children in the womb, to whom Eufillin was prescribed in the last trimester, should be under medical supervision for the first 28-30 days after birth. In gynecology, the drug is used for edema, placental insufficiency and gestosis as part of complex therapy. There is no clear treatment regimen, the attending physician selects the dosage individually.

Eufillin: instructions for use in ampoules

Many are interested in the question of whether it is possible to drink the drug in ampoules. Experts do not recommend taking the solution inside. Eufillin can be administered intramuscularly and intravenously. The drug may be present in the composition of microclysters and inhalation solution.

Intramuscular administration

Intramuscularly, the patient is administered no more than 1 ml of the drug once. At the ampoule, the tip is carefully broken off, the solution is drawn into a sterile syringe and excess air is released. For injections, thick and long needles are considered the most suitable: it is problematic to remove thin ones from the muscle, they constantly slide off the holder. The drug is injected into the upper corner of the buttock. Eufillin injection is painful, discomfort can persist for several hours. A hematoma often forms at the injection site. The drug is not administered subcutaneously.

Intravenous administration

Intravenous administration provides faster absorption of the active ingredient. Patients in serious condition are given a single loading dose of the drug: up to 5.5 mg / kg. To prepare a dropper, up to 20 ml of Eufillin is injected into a solution of sodium chloride (0.9%, 15-20 ml). The resulting mixture is poured into the remaining saline solution (up to 500 ml), drip administration is carried out for 30-40 minutes.

Asthmatic status requires intravenous administration of up to 720 mg of aminophylline. The daily norm is not more than 0.5 ml / kg. For an adult patient, a single patient dose (provided that the solution is injected into a vein) is 6-7 mg / kg. The drug must be diluted with sodium chloride. The duration of the jet injection is 2-4 minutes.

Adolescents are prescribed medication at a dose of 16 mg / kg per day. It is advisable to divide the therapeutic norm into several introductions. If necessary, it can be increased with the permission of a specialist. The course of treatment is 10-14 days.

Insertion with a probe

Newborns who are in serious condition, the drug is administered through a nasogastric tube. A narrow bore catheter is passed through the nasal cavity into the stomach. For the introduction of the drug most often use the Levin catheter. The probe is installed by a medical professional with the appropriate qualifications. The dosage regimen is selected by the pediatrician.

Microclysters

Microclyster with Eufillin can be prepared independently, at home. To do this, take 0.5 mg of the drug and dissolve it in 20 ml of boiled water at room temperature. The finished solution is collected in a rubber bulb (the tip is disinfected in advance) and administered rectally. The procedure is repeated every 3-4 hours. Enemas are contraindicated in children under 16 years of age.

Electrophoresis with the use of the drug is prescribed for adults suffering from osteochondrosis and arthritis. For children, the procedure is prescribed for dysplasia or to relieve intracranial pressure. Electrophoresis allows you to achieve the desired concentration of the main component in the affected tissues.

The drug acts pointwise, so systemic side effects are rare. Electrophoresis is prescribed for newborns older than 30 days. A napkin soaked in the solution is applied to the sore spot and the electrodes are fixed. The duration of the procedure does not exceed 15 minutes, during which time the medicine penetrates into the affected areas. The course of treatment is 8-10 sessions.

To restore the functional activity of the internal organs after birth injuries, newborns undergo electrophoresis according to Ratner. The child is given 2 napkins soaked in various drugs: 1 - a solution of aminophylline (on the cervical vertebrae), 2 - a solution of papaverine (on the ribs). Current strength - no more than 2 mA. Duration - 15 minutes. The procedure has practically no contraindications, apart from skin diseases, arterial hypertension, arrhythmia and heart failure.

Inhalations

Inhalations with Eufillin are prescribed for adults and children with bronchial obstruction and dry cough. The active ingredient quickly penetrates the systemic circulation and reaches the affected organ. The procedure is carried out using a special device - a nebulizer. Eufillin diluted in warm water is poured into a special compartment. The released vapors must be inhaled for 10 minutes. The procedure is repeated 2 times a day.

Side effects and overdose

Side effects occur with an incorrectly selected dosing regimen. These include:

• tachypnea;
• pain in the chest;
• flushed face;
• increased sweating;
• hematuria;
• frequent urge to urinate;
• albuminuria;
• hypoglycemia;
• fever
• rashes on the skin;
• loss of appetite;
• change in taste preferences;
• exacerbation of an ulcer;
• uncontrolled vomiting;
• heartburn;
• pain in the epigastric region;
• diarrhea
• bouts of nausea;
• angina pectoris of uncontrolled type;
• lowering blood pressure;
• cardialgia;
• cardiopalmus;
• arrhythmia;
• sleep disorders (drowsiness/insomnia);
• tremor;
• psychoemotional overexcitation (anxiety, aggression, irritability);
• dizziness;
• headaches.

Ailments are often dose-dependent, so experts recommend adjusting the dosing regimen in the direction of decreasing it if side effects appear.

Overdose symptoms develop with a multiple increase in the daily allowance. The characteristic features are:

• convulsions, light or sound phobia;
• tremor;
• arrhythmia;
• overexcitation;
• hyperemia of the skin;
• uncontrolled vomiting;
• prolonged diarrhea.

Eufillin does not have a specific antidote. A patient who has symptoms of an overdose must be taken to the nearest medical facility: gastric lavage and taking enterosorbents will not help in this case. Removal of toxins is carried out by enhancing the processes of natural detoxification (formed diuresis).

If the dose introduced into the body exceeds 0.5 mg / ml, then the patient is provided with respiratory support (artificial ventilation of the lungs), hemodialysis, hemosorption and plasmapheresis are performed. The doctor should monitor the hemodynamic parameters. If the patient has convulsions, Diazepam is administered intramuscularly. Barbiturates are strictly prohibited.

special instructions

A toxic effect develops if the concentration of the main component in the blood reaches 0.03 mg / ml. Eufillin has a stimulating effect on the respiratory organs only if the content of the substance in the blood does not exceed 0.01 mg / ml. Children under 3 years of age and elderly patients require careful use, the medication for this category of patients is prescribed as a last resort.

The drug can be used in geriatrics: it is prescribed in minimal doses. During the treatment period, experts recommend completely abandoning drinks containing caffeine and taurine. Chocolate and strong black hare are to be excluded from the diet. Before injection, the syringe with the solution should be held in your hands for a while so that it warms up.

Alcohol compatibility

The drug has a negative compatibility with alcohol. Before starting treatment, the patient is instructed to completely abandon the use of drinks that contain ethanol.

Interaction with other drugs

Beta-blockers, caffeine, ephedrine and Furosemide can enhance the effect of Eufillin, so these components are rarely combined. The therapeutic activity of the drug is reduced by Carbamazepine, Sulfinpyrazone, Rifampicin, Isoniazid, Phenobarbital and Phenytoin, so the dose of the bronchodilator is increased. In patients who smoke more than 15-20 cigarettes per day, there is an accelerated metabolism of Eufillin.

With the simultaneous use of antiviral drugs, beta-blockers, Disulfiram, Fluvoxamine, Viloxazine, Lincomycin, Cimetidine, Isoprenaline, Allopurine, macrolide antibiotics with Eufillin, the therapeutic dose of the latter should be increased. If the patient was prescribed a bronchodilator in combination with fluoroquinolone antibiotics, the dose of Eufillin is reduced by 25%.

Hypoglycemia develops with the combined use of diuretics, glucocorticosteroids and a drug with a bronchodilatory effect. Eufillin enhances the therapeutic effect of anticoagulants. Solutions of levulose, glucose and fructose are incompatible with the drug. The drug can be diluted only with sodium chloride.

Terms of dispensing from pharmacies

The drug, regardless of the form of release, requires a prescription from pharmacies. Before buying, the patient must present to the pharmacist a form with the seal of the attending physician. The drug is included in list B. The approximate cost is from 15 rubles.

Storage conditions and shelf life

Opened packages are strictly forbidden to be kept in the public domain. They are stored in a safe place for pets and children. For these purposes, cabinet shelves are used (preferably the top ones). Storage temperature - no more than 18 ° C. Shelf life - 24 months.

Analogues (briefly)

The drug has several generics with a similar therapeutic effect. These include:

1. Theotard. Produced in the form of capsules. It contains theophylline, a derivative of xanthine. It has a bronchodilating effect, quickly eliminating the obstruction of the bronchial canals. The cost is 180-195 rubles.
2. Teopak. Release form - tablets. The main component is a phosphodiesterase inhibitor, a purine derivative. Due to the ability of the drug to have a vasodilatory effect, the blood flow in the kidneys increases, the smooth muscles of the bronchi relax. Price - from 200 rubles.
3. Aerofillin. The active ingredient is doxophylline. The drug is sold in the form of tablets. The antispasmodic is able to have a bronchodilatory effect. The contractile function of the smooth muscle tissue of the bronchi decreases with systematic use. The cost is 122 rubles.
4. Neophyllin. Long-acting tablets contain theophylline. Bronchodilator is able to improve the functional activity of the respiratory and intercostal muscles. Price - 55 rubles.

The drugs are in different price categories. Each of them has a number of contraindications, so medications are prescribed by a doctor after a detailed examination. Self-selection of medication is strictly prohibited.

Eufillin dropper in ampoules is used to treat pathologies that are accompanied by airway obstruction and other diseases with spasms of smooth muscles. It contains the active ingredient theophylline. Release form: solution with different concentrations of this ingredient, packaged in glass ampoules. The drug is used for intramuscular injection. When diluting the drug in water, you can use it for intravenous injections. The dosage and duration of treatment is prescribed by the attending physician.

What is this drug?

Eufillin is an antispasmodic that helps to relax the smooth muscles of the uterus, bronchi, and bile ducts. After application, the drug eliminates spasm and muscle contractions. For example, in diseases of the bronchi, it reduces spasm, with the threat of miscarriage, it eliminates excessive uterine contractions.

The medicine Eufillin is produced by several manufacturers. The brand name may be different because pharmaceutical factories tend to register their own brand. This is Eufillin-Darnitsa and UBF. However, the composition of the solution does not change. It is produced according to the same formula that was patented many years ago.

Release form

The drug is available in the form of a solution for injection and tablets. Solutions are of two types:

• for intramuscular injection (concentration of 24% aminophylline).
• for intravenous administration (concentration 2, 4% aminophylline).

Additionally, the composition of the solution includes water and a preservative. The preservative is determined by the formula of the manufacturing plant.

Action on the body

With the use of aminophylline, the work of the muscles between the ribs and the ventilation of the alveolar space improve. The drug enhances the local immune defense of the mucous membranes from aggressive pathogenic agents (viruses, bacteria). It expands the lumen of blood vessels, relieving the tension of their walls, reduces the pressure of blood flow in the lungs. The drug improves the functioning of the heart muscle, enhances the production of adrenaline, and has a diuretic effect.

The dropper prevents the formation of blood clots and prolongs the life of red blood cells in the body. It relaxes the walls of the uterus during muscle contractions, threatening premature birth and abortion.

Indications for treatment

Eufillin is recommended if the patient has chronic obstructive pulmonary disease, asthma, bronchitis, and sleep apnea. It is used to reduce high intracranial pressure, to eliminate asthma attacks, with impaired blood circulation in the brain, which develops with strokes and its edema.

Eufillin injections are intravenously prescribed if the patient develops heart failure in acute or chronic form. Such injections lower the pressure in the vessels of the lungs, relieve swelling in kidney diseases. The medicine helps with neuralgia (like Milgamma and its substitutes). It is used in gynecology at the risk of premature birth or at the risk of miscarriage. It has a relaxing effect on the smooth muscles of the uterus and relieves spasms. Do not recommend a dropper at home.

Contraindications of the drug

Eufillin has a synthetic nature and a number of contraindications in which it should not be used:

• It is not recommended to give injections with aminophylline for heart attacks, arrhythmias, tachycardia.
• Do not put them with attacks of epilepsy, peptic ulcer of the gastrointestinal tract (acute phase), with gastritis.
• Treatment with an injection solution should not be carried out if the patient has severe liver disease, kidney disease, there is a risk of retinal hemorrhage.
• It is forbidden to take it with intolerance to aminophylline.

Doctors recommend using it with caution for the treatment of children under 14 years of age, elderly patients. The risk group also includes nursing mothers, pregnant women, people suffering from atherosclerosis. Such treatment is carried out only under the supervision of the attending physician, with any side effects or deterioration in health, the medicine is canceled.

Instructions for use

The dosage of the drug and the duration of the course of treatment is determined based on the diagnosed disease, age, weight of the patient and other factors:

• If a person is in a state where emergency care is needed, then the solution is administered intravenously over 30 minutes at a dosage of 5.6 mg per kilogram of weight.
• For droppers, the drug is brought to the required concentration with an aqueous solution of NaCl and saline.
• For routine maintenance treatment, injections are given intravenously at a dosage of 0.9 mg per kilogram of body weight.
• When taking theophylline before treatment with this medication, the dosage should be halved.
• The maximum daily dose varies from 0.4 to 0.5 ml per kg of patient weight.
• When treating young children, consultation with a doctor is required. Newborns and children under the age of 3 months can be administered no more than 60 mg of the active substance per day. In children older than 3 months, the dosage varies from 60 to 500 mg per day.
• For the treatment of COPD in children, the initial dose should not exceed 6 mg per kg of body weight.
• The course of treatment depends on the patient's performance, the diagnosis and the effectiveness of therapy. It may take several months.

Side effects of Eufillin

After taking the medicine, patients may experience anxiety, insomnia. They feel dizzy, their limbs cramp, and their muscles begin to tremor. At the same time, the work of the heart muscle is disrupted, heart palpitations begin. After the injections, a migraine occurs, the patient is agitated, quickly irritated.

If a woman is pregnant, then heart palpitations and arrhythmia may occur when taking the medicine in the last months of the term. In addition, angina pectoris develops, blood pressure rises. With a long course of treatment with aminophylline, appetite may decrease, nausea occurs, and there are bouts of vomiting. Sometimes the drug provokes diarrhea or the development of stomach and duodenal ulcers.

• Side effects can manifest as a rash on the skin, a person has a fever, and itching appears.
• Pain in the sternum may develop, diuresis increases, the person sweats heavily.
• It is often enough to simply reduce the dose of the drug to minimize the side effects that have occurred.
• After a skin puncture, this area may hurt, swell. There are seals and swelling.

Overdose: symptoms and patient care

After the introduction of too large a dose of the drug, the appetite worsens, diarrhea develops, there is vomiting with blood, nausea. After an overdose, tachycardia may begin, internal gastric bleeding develops. There may be problems with sleep, convulsions and tremors in the limbs begin, photophobia and tachycardia develop.

When the dose is increased, the patient may be agitated, he starts having epileptic seizures, develops hypokalemia, and blood pressure drops. A person often begins confusion and kidney failure.

To stop the symptoms and improve the condition, it is necessary to stop the drug. The patient is washed out the stomach, given laxatives and activated charcoal. Symptomatic treatment is also carried out with metoclopramide and ondansetron if the patient vomits. For convulsions, oxygen therapy with airway support is recommended.

With epileptic seizures, it is necessary to give the patient an intravenous injection of diazepam. If a person vomits strongly, then intravenous injections of metoclopramide, ondansetron should be administered.

Nuances of application

The drug should be used with caution in heart attacks, angina pectoris, atherosclerosis. Under the supervision of a physician, treatment is carried out for renal and hepatic insufficiency, with a stomach ulcer or gastrointestinal tract. Treatment should be monitored for hypothyroidism, thyrotoxicosis, and prostatic hypertrophy.

The drug should be used with caution in the treatment of the elderly and children. This is especially true when taking pills.

Reducing the dosage may be necessary in case of impaired liver function, with chronic alcohol dependence, if a person has a fever, with acute respiratory disease. Dose reduction is possible when treatment is given to an elderly person. If a drug with the same active substance is chosen, then regular tests should be carried out to determine its concentration in the blood.

1. During treatment, you should not drink strong brewed tea and coffee, take theophylline and purine derivatives.
2. Do not combine the drug with beta-blockers.
3. It is not recommended to inject if you have to drive a car or other mechanisms. The ingredients of the drug, being absorbed into the blood, scatter attention, the sharpness of reactions is lost.

Medication during pregnancy

The instructions for use state that its use at this time may threaten the health of the child. In the blood of a newborn, doctors often detect a high concentration of caffeine and aminophylline.

If the mother undergoes a course of injections with this remedy, but the children are observed by doctors after birth to exclude xanthine intoxication. When taking aminophylline, doctors assess the risks and possible consequences. The medicine is prescribed for extreme vital signs.

Why pregnant women are prescribed aminophylline?

Indications during the gestation period:

• Tissue swelling.
• placental insufficiency.
• Preeclampsia.
• The threat of miscarriage or premature birth.

Pregnancy in the annotation is prescribed as a contraindication, so there is no clear treatment regimen. The doctor prescribes the dosage and schedule of admission, based on the diagnosis of the woman, her state of health. In pregnant women, during the course of treatment, a strong heartbeat may begin, weakness is observed.

Electrophoresis with the drug

This procedure is performed for people of any age to relax the muscles, reduce intracranial pressure. It is used in complex therapy for diseases of the joints. Electrophoresis is used to improve blood circulation in certain areas (neck, lower back). It acts pointwise, without having a systemic effect. Therefore, the procedure is used even for infants and is well tolerated by all groups of patients.

To carry out the procedure, a piece of gauze is wetted in the medicine (at a concentration of 2.4%), electrodes are applied to the desired area. During the procedure, the patient feels warmth or tingling. The course of treatment is 10 sessions of 10-15 minutes. The procedure is done every other day, then a break is needed.

Eufillin and alcoholic drinks

The drug is not combined with alcohol, because it increases the toxic effect on the body, enhancing the effects of the drug. Against this background, pressure drops, suffocation begins, the heartbeat quickens, arrhythmia and tachycardia develop. Due to the relaxation of the muscles of the lungs, sometimes there is a complete cessation of breathing, with weakened vessels of the brain, hemorrhages are possible. In rare cases, taking alcohol and aminophylline at the same time provokes a fatal outcome.

Storage conditions, holiday conditions

The medicine is dispensed by prescription. Its cost depends on the form of release and varies from 11 to 94 rubles per pack.

in a blister 10 pcs.; in a pack of cardboard 3 blisters.

pharmachologic effect

pharmachologic effect- antispasmodic, diuretic, bronchodilator.

Dosage and administration

Inside, 1 tablet 3-4 times a day.

Storage conditions of the drug Eufillin

In a place protected from light, at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life of the drug Eufillin

5 years.

Do not use after the expiry date stated on the packaging.

Instructions for medical use

Eufillin
Instructions for medical use - RU No. LSR-000883/09

Last Modified Date: 24.05.2016

Dosage form

Solution for intravenous administration.

Composition

Active substance:

Aminophylline (eufillin) (in terms of dry matter) - 24.0 mg

Excipients:

Water for injection - up to 1 ml.

Description of the dosage form

Clear colorless or yellowish liquid.

Pharmacological group

Bronchodilator.

Pharmacodynamics

The drug inhibits phosphodiesterase, increases the accumulation of cyclic adenosine monophosphate in tissues, blocks adenosine (purine) receptors; reduces the flow of Ca2 + through the channels of cell membranes, reduces the contractile activity of smooth muscles. Relaxes the muscles of the bronchi, stops bronchospasm, increases mucociliary clearance, stimulates diaphragm contraction, improves the function of the respiratory and intercostal muscles, stimulates the respiratory center, increases its sensitivity to carbon dioxide and improves alveolar ventilation, which ultimately leads to a decrease in the severity and frequency of apnea episodes. By normalizing the respiratory function, it helps to saturate the blood with oxygen and reduce the concentration of carbon dioxide. Enhances lung ventilation in conditions of hypokalemia.

It has a stimulating effect on the activity of the heart, increases strength and heart rate, increases coronary blood flow and myocardial oxygen demand. Reduces the tone of blood vessels (mainly the vessels of the brain, skin and kidneys). It has a peripheral venodilating effect, reduces pulmonary vascular resistance, lowers pressure in the "small" circle of blood circulation. Increases renal blood flow, has a moderate diuretic effect. Expands the extrahepatic bile ducts.

Stabilizes mast cell membranes, inhibits the release of mediators of allergic reactions.

It inhibits platelet aggregation (suppresses the platelet activating factor and prostaglandin E2, increases the resistance of erythrocytes to deformation (improves the rheological properties of blood), reduces thrombosis and normalizes microcirculation.

It has a tocolytic effect, increases the acidity of gastric juice. When used in high doses, it has an epileptogenic effect.

Pharmacokinetics

Bioavailability for liquid dosage forms - 90-100%. TSmax at the on / in the introduction of 0.3 g - 15 minutes, the value of C max - 7 μg / ml. The volume of distribution is in the range of 0.3-0.7 l/kg (30-70% of the "ideal" body weight), with an average of 0.45 l/kg. Communication with plasma proteins in adults - 60%, in newborns - 36%, in patients with cirrhosis of the liver - 36%. Penetrates into breast milk (10% of the accepted dose), through the placental barrier (the concentration in the blood serum of the fetus is slightly higher than in the mother's serum).

Aminophylline exhibits bronchodilating properties at concentrations of 10-20 μg / ml. Concentration over 20 mg/ml is toxic. The excitatory effect on the respiratory center is realized at a lower content of the drug in the blood - 5-10 μg / ml.

It is metabolized at physiological pH values ​​with the release of free theophylline, which is further metabolized in the liver with the participation of several cytochrome P450 isoenzymes. As a result, 1,3-dimethyluric acid (45-55%) is formed, which has pharmacological activity, but is 1-5 times inferior to theophylline. Caffeine is an active metabolite and is formed in small quantities, with the exception of premature infants and children under 6 months of age, in which, due to the extremely long T1 / 2 of caffeine, its significant accumulation in the body occurs (up to 30% of that for aminophylline).

In children older than 3 years and in adults, the phenomenon of caffeine accumulation is absent.

T1 / 2 in newborns and children under 6 months - more than 24 hours; in children older than 6 months - 3.7 hours; in adults - 8.7 hours; in "smokers" (20-40 cigarettes per day) - 4-5 hours (after quitting smoking, normalization of pharmacokinetics after 3-4 months); in adults with COPD, cor pulmonale and pulmonary heart failure - over 24 hours. Excreted by the kidneys. In newborns, about 50% of theophylline is excreted in the urine unchanged versus 10% in adults, which is associated with insufficient activity of liver enzymes.

Indications

Asthmatic status (additional therapy), neonatal apnea, ischemic cerebrovascular accident (as part of combination therapy), left ventricular failure with bronchospasm and respiratory failure of the Cheyne-Stokes type, edematous syndrome of renal genesis (as part of complex therapy).

Contraindications

Hypersensitivity to the drug, as well as to other xanthine derivatives: caffeine, pentoxifylline, theobromine. Severe arterial hypotension or hypertension, paroxysmal tachycardia, extrasystole, myocardial infarction with heart rhythm disturbances, epilepsy, increased convulsive readiness, hypertrophic obstructive cardiomyopathy, thyrotoxicosis, pulmonary edema, severe coronary insufficiency, liver or kidney failure, hemorrhagic stroke, retinal hemorrhages, bleeding in a recent history, lactation period.

Carefully:

Pregnancy, neonatal period, old age (over 55 years), uncontrolled hypothyroidism (possibility of cumulation), widespread vascular atherosclerosis, sepsis, prolonged hyperthermia, prostate adenoma. The drug is not recommended for intravenous administration in children under 14 years of age (due to possible side effects).

Dosage and administration

In emergencies, adults are injected intravenously slowly (within 4-6 minutes), 5-10 ml of the drug (0.12-0.24 g), which is previously diluted in 10-20 ml of 0.9% sodium chloride solution.

With asthmatic status, intravenous drip administration is indicated - 720-750 mg.

Higher doses for adults intravenously - single 0.25 g, daily 0.5 g.

Higher doses for children intravenously - single 3 mg / kg, daily - under the age of 3 months - 0.03-0.06 g, from 4 to 12 months - 0.06-0.9 g, from 2 to 3 years 0 09-0.12 g from 4 to 7 years - 0.12-0.24 g, from 8 to 18 years - 0.25-0.5 g.

Side effects

From the side of the central nervous system: dizziness, headache, insomnia, agitation, anxiety, irritability, tremor.

From the side of the cardiovascular system: palpitations, tachycardia (including in the fetus when taken by a pregnant woman in the third trimester), arrhythmias, lowering blood pressure, cardialgia, an increase in the frequency of angina attacks.

Allergic reactions: skin rash, skin itching, fever.

Others: chest pain, tachypnea, flushing, albuminuria, hematuria, hypoglycemia, increased diuresis, increased sweating.

Side effects decrease with a decrease in the dose of the drug.

Local reactions: hardening, hyperemia, soreness at the injection site.

Overdose

Symptoms: loss of appetite, gastralgia, diarrhea, nausea, vomiting (including with blood), gastrointestinal bleeding, tachypnea, flushing of the skin of the face, tachycardia, ventricular arrhythmias, insomnia, motor agitation, anxiety, photophobia, tremor, convulsions. In severe poisoning, epileptoid seizures can develop (especially in children without any precursors), hypoxia, metabolic acidosis, hyperglycemia, hypokalemia, lowering blood pressure, skeletal muscle necrosis, confusion, renal failure with myoglobinuria.

Treatment: drug withdrawal, forced diuresis, hemosorption, plasmasorption, hemodialysis (low efficiency), symptomatic therapy (including metoclopramide and ondansetron - with vomiting). If convulsions occur, maintain airway patency and provide oxygen therapy. For the relief of a seizure - in / in diazepam 0.1-0.3 mg / kg (but not more than 10 mg). Barbiturates should not be used. With severe nausea and vomiting, hemodialysis is recommended.

Interaction

Pharmaceutically incompatible with acid solutions. Increases the likelihood of side effects of corticosteroids, ISS (hypernatremia), general anesthesia (increases the risk of ventricular arrhythmias), agents that excite the central nervous system (increases neurotoxicity). Rifampicin, phenobarbital, phenytoin, isoniazid, carbamazepine, sulfinpyrazone, aminoglutethimide, oral estrogen-containing contraceptives and moracizin, being inducers of microsomal oxidation, increase the clearance of aminophylline, which may require an increase in its dose. With simultaneous use with antibiotics of the macrolide group, lincomycin, allopurinol, cimetidine, isoprenaline, enoxacin, small doses of ethanol, disulfiram, fluoroquinolones, recombinant interferon alfa, methotrexate, mexiletine, propafenone, thiabendazole, ticlopidine, verapamil and when vaccinated against influenza, the intensity of the action of aminophylline may increase, which may require a dose reduction. Enhances the action of beta-adrenergic stimulants and diuretics (including by increasing glomerular filtration), reduces the effectiveness of Li + drugs and beta-blockers.

Compatible with antispasmodics, do not use in conjunction with other xanthine derivatives. With caution appoint simultaneously with anticoagulants.

special instructions

Exercise caution when consuming large amounts of caffeinated foods or drinks during treatment. Before the introduction of the solution must be heated to body temperature. Elderly patients are advised to reduce the dose of the drug due to its delayed excretion from the body. Smoking patients are advised to increase the dose due to the accelerated excretion of the drug from the body.

Release form

Solution for intravenous administration 24 mg/ml.

Ampoules of 5 ml and 10 ml. 10 ampoules in a cardboard box along with instructions for use. 5 ampoules in a blister pack. 1 or 2 blister packs in a cardboard box along with instructions for use. An ampoule knife or a scarifier is put into each pack. When packing ampoules with a dot or a break ring, an ampoule knife or a scarifier is not inserted.

Storage conditions

In a dry, dark place at a temperature not exceeding 30°C.

Keep out of the reach of children.

Best before date

3 years. Do not use after the expiry date stated on the packaging.

Terms of dispensing from pharmacies

Released by prescription.

R N002436/01 dated 2018-04-27
Eufillin - instructions for medical use - RU No. LP-003432 dated 2016-02-02
Eufillin - instructions for medical use - RU No. LSR-004120/09 dated 2013-08-15
Eufillin - instructions for medical use - RU No. LSR-005887/08 dated 2015-02-02
Eufillin - instructions for medical use - RU No. LS-000590 dated 2017-11-10
Eufillin - instructions for medical use - RU No. LSR-003895/07 dated 2018-02-28
Eufillin - instructions for medical use - RU No. LSR-002209/07 dated 2011-04-21
Eufillin - instructions for medical use - RU No. LS-000371 dated 2011-10-13
Eufillin - instructions for medical use - RU No. LS-001569 dated 2018-02-28
Eufillin - instructions for medical use - RU No. LS-002028 dated 2018-04-03
Eufillin - instructions for medical use - RU No. LS-000371 dated 2005-06-10
Eufillin - instructions for medical use - RU No. LSR-000883/09 dated 2016-05-24
Eufillin - instructions for medical use - RU No. LS-001731 dated 2017-11-29

Synonyms of nosological groups

Category ICD-10	Synonyms of diseases according to ICD-10
G46 Vascular cerebral syndromes in cerebrovascular diseases	post-apoplexy state
	Chronic cerebrovascular insufficiency
G93.6 Cerebral edema	Intraoperative cerebral edema
	cerebral edema
	Cerebral edema in case of poisoning
	Cerebral edema associated with radiotherapy
	Cerebral edema associated with head trauma
	Post-traumatic cerebral edema
	Post-traumatic cerebral edema
I27 Other forms of pulmonary heart disease	Secondary pulmonary hypertension
	Hypertension of the pulmonary circulation
	Pulmonary hypertension
	Pulmonary heart failure
	Pulmonary heart
	Cardiopulmonary failure
	Chronic pulmonary heart disease
	Chronic cor pulmonale
	Eisenmenger syndrome
I50.1 Left ventricular failure	Asthma cardiac
	Asymptomatic left ventricular dysfunction
	Asymptomatic left ventricular heart failure
	Left ventricular diastolic dysfunction
	Left ventricular dysfunction
	Left ventricular changes in myocardial infarction
	Lung changes in left ventricular failure
	Left ventricular heart failure
	Left ventricular dysfunction
	Left ventricular failure
	Acute left ventricular failure
	Acute cardiac left ventricular failure
	Precordial pathological pulsation
	cardiac asthma
	Heart failure, left ventricular
J42 Chronic bronchitis, unspecified	allergic bronchitis
	Asthmoid bronchitis
	Bronchitis allergic
	Bronchitis asthmatic
	Bronchitis chronic
	Inflammatory disease of the airways
	Bronchial disease
	Qatar smoker
	Cough in inflammatory diseases of the lungs and bronchi
	Exacerbation of chronic bronchitis
	Recurrent bronchitis
	Chronic bronchitis
	Chronical bronchitis
	Chronic bronchitis of smokers
	Chronic spastic bronchitis
J43 Emphysema	Interstitial emphysema
	Obstructive emphysema
	Chronic obstructive pulmonary emphysema
	Chronic emphysema
	Chronic lung disease
	Chronic obstructive pulmonary disease
	Emphysema
J45 Asthma	Asthma of physical effort
	Asthmatic conditions
	Bronchial asthma
	Mild bronchial asthma
	Bronchial asthma with difficulty in sputum discharge
	Severe bronchial asthma
	Bronchial asthma physical effort
	hypersecretory asthma
	Hormone-dependent form of bronchial asthma
	Cough with bronchial asthma
	Relief of asthma attacks in bronchial asthma
	Non-allergic bronchial asthma
	Nocturnal asthma
	Nocturnal asthma attacks
	Exacerbation of bronchial asthma
	Asthma attack
	Endogenous forms of asthma
J98.8.0* Bronchospasm	Bronchospasm in bronchial asthma
	Bronchospasm when exposed to an allergen
	Bronchospasm reactions
	Bronchospastic conditions
	bronchospastic syndrome
	Diseases accompanied by bronchospastic syndrome
	Reversible bronchospasm
	Spasmodic cough
N28.9 Disease of kidney and ureter, unspecified	Autoimmune kidney disease
	kidney disease
	Megaloureter
	Renal blood flow disorder
	Dysfunction of the ureters
	Impaired kidney function
	Kidney dysfunction
	Non-diabetic nephropathy
	Insufficiency of the excretory function of the kidneys
	Nephrogenic osteopathy
	Nephropathic syndrome
	minimal change nephropathy
	Maintenance of kidney function
	Chronic kidney disease
R60 Edema, not elsewhere classified	Painful swelling after injury or surgery
	Painful swelling after surgery
	Dropsy
	Dystrophic alimentary edema
	Lymphostasis and edema after breast cancer therapy
	Swelling due to sprains and bruises
	Edema caused by the constitution
	Edema of renal origin
	Edema peripheral
	Edema-ascitic syndrome in liver cirrhosis
	Edema syndrome
	Edema syndrome intoxication
	Edema syndrome on the background of secondary hyperaldosteronism
	Edema syndrome of hepatic genesis
	Edema syndrome in heart disease
	Edema syndrome in congestive heart failure
	Edema syndrome in heart failure
	Edema syndrome in heart failure or liver cirrhosis
	Pastosity
	Peripheral congestive edema
	peripheral edema
	Hepatic edematous syndrome
	premenstrual edema
	Cardiac edematous syndrome
	iatrogenic edema

Instructions for use "Euphyllin" in ampoules explains what kind of drug it is and when it is prescribed. The drug solution is used for intravenous and intramuscular droppers, inhalations are carried out with it. The Latin name of the drug is euphyllini, and you can buy it in pharmacies with a doctor's prescription.

2, 4% solution of "Euphyllin" is produced in ampoules of 5 and 10 ml; 1 ml contains 24 mg aminophylline and water for injection. Methods by which the drug should be administered:

• intravenous jet;
• intramuscular;
• drip.

The glass ampoule, sealed on top, contains a clear liquid. A high-quality solution is colorless, without impurities and sediment. The release of the drug is carried out by Moskhimfarmpreparaty named after N.A. Semashko, as well as CJSC "Darnitsa" Kyiv.

The price of the product depends on the dosage and the number of packed ampoules, varies from 15 to 26 UAH.

Analogues of "Eufillina":

• Aerofillin;
• "Neophyllin";
• "Puroxan";
• "Teopec";
• "Theotard";
• "Teofidrin".

The instruction states that these drugs have a bronchodilator effect and their use gives the same therapeutic effect as the use of Eufillin.

Before using substitutes, you should consult your doctor. He will prescribe another drug if there are contraindications to this.

Pharmacological ability

The action of "Eufillin" is aimed at reducing the tone of smooth muscles. Under the influence of the drug, muscle spasm decreases. This property of the drug is used by official medicine to treat congestive conditions, the injection improves vascular circulation, helps to cleanse the bronchi. Euphyllin injections have the following therapeutic effects:

• relieve spasm in the bronchi;
• activate the respiratory center;
• increase myocardial HR;
• improve coronary circulation;
• lower vascular tone;
• prevent the development of allergies.

The range of pathologies in which the Euphyllin solution is used is quite wide, but the main indication for the use of the drug is the relief of bronchospasm.

When applied

"Eufillin" is injected intramuscularly or intravenously to eliminate a critical condition, regardless of the factors that caused it. Tablets should be drunk in the chronic form of the disease with periodic exacerbations. The doctor determines the course of taking the medicine, as well as the method of its use.

Eufillin in ampoules helps with the following pathologies:

• bronchial asthma;
• lingering cough;
• obstructive bronchitis;
• pulmonary emphysema;
• sleep apnea of ​​newborns;
• heart asthma;
• stagnation of the pulmonary circulation.

Newborns for the treatment of apnea are injected with a solution of "Euphyllin" using a probe (dosage 0.5 g per 1 kg of baby's weight). Adult patients are prescribed the drug parenterally, it should be injected in case of violation of the respiratory function of the Cheyne-Stokes type (shallow and rapid breathing) in combination with other medicines.

Application methods

Intravenous bolus should be injected slowly, monitor the patient's condition, talk to him during the procedure. It is important to prepare the injection solution correctly. To do this, 5 ml of the drug is diluted in 15 ml of sodium chloride, the mixture is heated to 35-37 degrees, and then an injection is made. So the remedy does not cause irritation and is well tolerated by patients.

It is better if the drug enters the body by drip. The preparation technology is the same, but 20 ml of 2.4% aminophylline is diluted with 150 ml of saline.

The technique of administering the drug assumes such a speed that its effect lasts for a day (the dispenser on the dropper is set at 35-45 drops / min).

An intramuscular injection is made in the upper outer square of the buttock. To do this, take a long needle, make sure that it is wider in cross section than for an intravenous injection. This will allow the drug to enter the muscle layer and spread throughout the body with the bloodstream. So the effect of the drug will come earlier than if "Eufillin" accumulates in the fat layer (when pricked with a small needle).

Use in pregnancy

Guidelines for the use of "Euphyllin" limits the use of the drug during childbearing. Penetrating through the placenta, the drug has a negative effect on the fetus. It does not cause developmental pathology, but after birth, the baby has arrhythmia, intoxication, and vomiting.

The medication does not lead to irreversible changes in the fetus, so it can be used with caution in pregnant women if there are indications (edema, placental insufficiency).

But during treatment, a woman must strictly adhere to the recommended dosage. You can not independently prescribe a drug to relieve symptoms. Gynecologists, prescribing "Eufillin", take into account the benefits of using and the potential harm of the drug.

Application by pediatricians

Often, "Eufillin" is used to treat pathologies of the respiratory tract in adults. But there are such critical conditions in babies when injections of the drug are administered at 3 months of age. For older children, intravenous and intramuscular injections are given to relieve acute symptoms caused by bronchospasm. After the introduction of the drug, the child is under the supervision of a doctor, since the drug has a pronounced effect on the function of the cardiovascular system.

Eufillin inhalations

This drug has no effect when used as a solution for inhalation.

It is known that the drug has a therapeutic effect only when it enters the bloodstream.

Accumulating on the mucous membrane of the nasopharynx and throat, the agent cannot enter the bloodstream, and the expectorant effect is achieved due to the effect of water vapor on the respiratory tract.

The antispasmodic effect of "Euphyllin" is observed only with i.v. or i.m. administration, and inhalations with it are ineffective.

Cough treatment

Cough syndrome, in which sputum discharge is difficult, worsens the condition of patients, causes pain in the lungs, is accompanied by whistling and wheezing, impaired respiratory function. To expand the bronchi and facilitate sputum secretion, patients are injected with "Eufillin". After stopping the attack, patients are transferred to tablets (adults 1 tablet, and children 1/4 three times a day), gradually reducing the number of doses to 1 time at night. It is useful to do inhalation with mineral water. This contributes to the rapid discharge of the secret.

Electrophoresis with "Eufillin"

There are many pathological conditions provoked by muscle hypertonicity. To relieve spasm and improve blood circulation, electrophoresis with "Eufillin" is used. This procedure is carried out in a hospital where the patient is under the supervision of a doctor. Adults are prescribed for the following pathologies:

• osteochondrosis;
• joint diseases;
• decrease in cerebral circulation;
• damage to the facial nerve;
• chronic bronchitis.

"Eufillin" for electrophoresis is prescribed by pediatricians for such disorders in infants:

• increased intracranial pressure;
• the "font" does not overgrow for a long time;
• muscle hypertonicity;
• cerebrovascular accident.

The drug administered through a weak electric current is well tolerated by patients, does not cause adverse reactions, since the substance accumulates in the affected area, bypassing the gastrointestinal tract and kidneys.

"Eufillin" from cellulite

To make the skin smooth and silky, many girls use Eufillin for massage or wrapping.

It improves blood circulation, relieves puffiness, warms up and tightens the skin by removing excess fluid. But before use, you should read the instructions, since the medicine has many contraindications.

When not to use

The drug has a negative effect on the gastrointestinal tract, so people with peptic ulcer, hyperacid gastritis or liver dysfunction "Eufillin" is contraindicated. In addition, it should not be prescribed to patients in such situations:

• allergy to components;
• hyper- or hypotension;
• hemorrhage in the brain;
• epileptic seizures;
• arrhythmia;
• tachycardia;
• multifocal atherosclerosis;
• myocardial infarction.

Also contraindications for admission are pathologies of the thyroid gland, pregnancy and lactation. With caution appoint "Eufillin" to the elderly.

Adverse reactions and overdose

Almost any drug can cause unwanted manifestations in the body. "Eufillin" is no exception.

Possible side effects when using this medicine are not so few. Here is a sample list of the main negative reactions:

• angioedema;
• skin rashes;
• fainting;
• insomnia;
• irritation;
• arrhythmia;
• dyspeptic disorders.

If the amount of accumulated drug in the body exceeds 20 mg / kg of body weight, the patient develops symptoms of an overdose of the drug:

• hyperemia of the skin;
• convulsions;
• excitation;
• violation of the heart rhythm;
• hypotension;
• kidney dysfunction;
• confusion.

Such disorders are often noted in elderly patients.

The accumulation of the drug in doses up to 40 mg / kg causes a coma.

Interaction with other drugs

"Eufillin" for injections can not be diluted with solutions containing acid.

Also, it does not need to be taken with glucocorticoids (Prednisolone, Dexamethasone), as the risk of an undesirable effect increases. Adsorbents reduce the effectiveness of "Euphyllin", so it should be drunk one hour after or one hour before taking sorbents.

The therapeutic property of the drug is enhanced by the use of macrolides or alcohol. Then the dose of the drug is reduced.

The drug increases the effect of diuretics and beta-agonists.

Shelf life and storage conditions

The product is valid for two years from the date of production. It must be stored in its original packaging at an air temperature not exceeding 25 * C.

Keep the drug out of the reach of children, direct sunlight should not fall on it. The medicine is dispensed in the prescription department of the pharmacy.