Furadonin will help in the treatment of cystitis. Furadonin - instructions for use Antibiotic furadonin instructions for use

Many people ask the question from what furadonin? Urological drug for the treatment of diseases of the genitourinary system provoked by microbes.

Today we will talk about what Furadonin is from, what diseases it treats, whether it can be combined with alcohol, how to use it for thrush. We will answer these and many other questions in the article today.

Description

Furadonin is a diuretic or not? The medication is not a diuretic. The drug is an anti-inflammatory agent that destroys microorganisms and bacteria of the intracellular membrane.

Nitrofurans are the main group of the drug, and its main substance is nitrofurantoin (Nitrofurantoin). Furadonin is not an antibiotic. Destroying germs and bacteria, it acts as an antiseptic agent on the body.

The difference between an antibiotic and an antiseptic is that the second destroys the harmful environment of the harmful microorganism, and not itself. The active substance blocks the translation (synthesis) of the protein in the microbial cell, disrupting the penetration into the plasma membrane.

The bacteria stop multiplying and growing. The drug fights against gram-negative and gram-positive microbes:

• "Staphylococcus aureus".
• "Streptococcus".
• Enterobacteriaceae.
• "Salmonella".
• "Proteus".
• "Shigella".
• "Klebsiella infection" (Klebsiella).
• Escherichia coli.

With long-term use of the medication, some microbes become resistant, but this happens very rarely. The medicine is often prescribed for cystitis of any form. In men, it treats urethritis well.

The drug fights against the causative agent of the inflammatory process itself and can be combined with other agents in the therapy of the bladder.

Self-medication is not worth it, the medicine has side effects and contraindications. The daily rate will be prescribed only by a doctor.

Composition, release form

	Uncoated tablets 1 pc.	Coated pills 1 pc.	Powder 1 g
Main component	"Nitrofurantoin" 0.5 or 10 g	active substance 0.03 g	1 g
Auxiliary components	potato (corn) starch, calcium (Ca) stearic acid, silicon dioxide, octadecanoic acid, polysorb	the same composition	+ water
Release and Description	light or green, round and oval	appearance similar to the shell of a yellow shade	powder
Packing material	12; 20; thirty; 40; 50 pcs.	on a cell blister 30 pcs.	packaged in 5 and 10 g in 1 pack

What furadonin helps from: indications

The drug is used in urology and gynecology. Treats acute and chronic ailments of the genitourinary system and kidneys.

Diseases:

1. Infectious processes of the urinary system;
2. Cystitis (cystitis) is acute and chronic;
3. Pyelonephritis (pyelonephritis);
4. Pyelitis (pyelitis);
5. Urethritis (urethritis);
6. Bacteriuria during pregnancy;
7. Paranephritis (paranephritis);
8. Infectious diseases of the urea;
9. Vaginal candidiasis;
10. Before manipulations and surgical intervention, as a preventive measure.

How to use

Drink the tablet preparation without chewing. Shake the suspension and pour into a measuring spoon. Use immediately after eating with 200 ml of liquid (milk, juice, etc.).

Pills:

• With cystitis (urethritis, pyelonephritis) and other infections of the urinary tract: adults take 1 tab. * 4 r. - 7 days;
• 6 - 12 years: suspension 8 mg * 1 kg of weight * 4 r.
• 12 years and older: 0.1 g * 2 p. Duration of treatment is not more than 7 days;
• Prevention of the genitourinary system: 1 t. * 1 p. (in the evening).

The form of the powder is used in rare cases according to the scheme for adults: 0.1 g * 4 r. The course is prescribed by a doctor; you should not self-medicate if it concerns children.

"Furadonin" with urethritis (urethritis)

Therapy for inflammation of the urethral canal with this drug should be combined with an antibacterial one. It is taken in 4 doses a day after a meal, washed down with a copious amount of liquid (more than 200 ml).

The course of treatment is prescribed according to the scheme, it can be up to 14 days. Follow the intervals, do not neglect this, as the treatment in this case will not be effective.

Furadonin from thrush can be taken with the recommendation of a gynecologist. The duration is 7-14 days. The treatment regimen and concomitant therapy drugs are prescribed by the doctor.

Many people believe that Furadonin also helps with prostatitis, but this is not the case. There are other remedies and medicines to treat the gland. For pyelonephritis, oxyquinolines and nitrofurans are prescribed, the latter group includes Furadonin.

There are a number of special indications that must be taken into account before starting therapy. You need to be careful when taking the drug for this category of patients:

• Anemia (anemia);
• Diabetes mellitus of any type;
• Electrolyte imbalance;
• Kidney pathology;
• Lack of vitamin B.

Perhaps the development after the start of therapy - peripheral neuropathy.

Furadonin is not used in the treatment of such diseases:

1. Purulent paranephritis (Paranifritis purulent);
2. Acute necrosis of the renal cortex;
3. Parenchymal jaundice;
4. Inflammation of the prostate gland.

The medicine has many side effects, so it should not be taken before driving. Urine turns into a bright yellow color, which is displayed after the end of the course of treatment.

Side effects and overdose

The drug has many negative effects, the following symptoms arise from Furadonin:

• Nausea, upset stools, vomiting;
• Muscle spasm (myalgia), shortness of breath;
• Pain in the chest, abdomen, signs of bronchial asthma;
• Lack of appetite, drastic weight loss;
• Inflammation of the lungs (pneumonia);
• Yellowing of the skin (hepatitis);
• Reversible anemia;
• Skin redness, acne and hives;
• Burning, itching, allergies;
• Dermatitis (dermatitis);
  Erythema (erythema);
• Chills, fever, fever;
• Cholestasis (cholestatic syndrome);
• Migraine;
• Joint pain (arthralgia);
• Quincke's edema;
• Inflammation of the pancreas;
• Anaphylactic shock (anaphylaxis).

Overdose

No cases were recorded. But if symptoms such as nausea, vomiting appear, it is necessary to rinse the stomach, take a sorbent - activated carbon or Enterosgel, which will help relieve intoxication. And the main thing is to drink plenty of water.

Contraindications

1. Disruption of the chls and kidney glomeruli;
2. Heart pathology;
3. Pregnancy, breastfeeding;
4. Age restrictions: children under one year old;
5. Glomerular nephritis;
6. Reduction of urine discharge (oliguria);
7. Individual intolerance;
8. Pathological processes of the liver (cirrhosis), chronic hepatitis;
9. Porphyrin disease;
10. Alcoholism, use with alcohol.

Combination with other drugs

Taking the following substances slows down the action of the drug and worsens the antibacterial effect:

• Nalidixic acid;
• Antacids;
• Magnesium trisilicate containing preparations;
• Fluoroquinolones;
• Medicines that alter and increase the acidity of urine;
• Sulfinpyrazone;
• Probenecid.

Furadonin and alcohol compatibility is prohibited, when drinking alcohol, the above side effects may occur.

Effects:

1. Arterial hypotension (lowering blood pressure);
2. Rapid heartbeat (tachycardia);
3. Shortness of breath, shortness of breath;
4. Vomiting, loose stools (diarrhea);
5. Allergic reactions (Quincke's edema);
6. Anaphylactic shock.

Shelf life and sale

The drug is prescribed by prescription of the attending physician and is freely available in pharmacies in the country. Storage conditions are the same as for other drugs.

• Save in a dark place;
• Temperature not higher than 20 ° C;
• Far from children;
• Use within 4 years, suspension within 1 month.

The cost of the drug varies from 70-170 rubles. It depends on the manufacturer, the price policy of the pharmacy and the form of release.

Analogs

There are no substitutes for Furadonin, but there are drugs that have the same therapeutic effect, only imported.

1. "Nifuroxazide" Nifuroxazidum;
2. "Furagin" Furagin;
3. Furamag Furamag.

Furadonin: instructions for use for children. The drug belongs to the group of antimicrobial drugs, intended for the treatment of infections of the urinary tract. Its use is permissible, both in acute and chronic disease. Furadonin can be taken by children from 1 month of age. But due to the toxicity of the drug and possible side reactions, it is recommended to use it only in a hospital setting or strictly observe the dosage prescribed by the doctor.

The drug "Furadonin"

General description of the medicinal product

The drug, the main active ingredient of which is nitrofurantoin, is a tablet used in therapy in children for the treatment of urinary tract infections caused by streptococci, staphylococci and other pathogenic microorganisms. The drug has high bioavailability and is excreted from the body mainly by the kidneys.

What diseases does a child have?

The medication is indicated for use with the following violations:

• disease of the mucous membrane of the bladder of an infectious nature;
• infectious and inflammatory processes in the kidneys;
• urinary tract infection;
• inflammation of the renal pelvis.

The medicine can also be prescribed for prophylactic purposes, after diagnostic tests or surgery.

How to take medicine correctly in childhood?

Furadonin's instructions for use for children contain the following information:

Patients under 12 years of age take medication at the rate of 5-7 mg per kilogram of body weight. Divide the received amount into a fourfold dose. A child over 12 years old takes 100 mg twice a day.

The course of treatment for cystitis is five to seven days. For other pathologies, the adjustment of the therapy period is determined by a specialist. During treatment, it is necessary to observe the drinking regimen, since the medicine should be taken with plenty of fluids. You should also drink as much water as possible throughout the day.

It is important to organize a drinking regimen

In what cases should a child not take Furadonin?

• chronic hepatic pathologies;
• severe disturbances in the work of the heart (heart failure);
• insufficiency of glucose-6-phosphate dehydrogenase;
• intolerance to nitrofurantoin;
• porphyria.

If an allergic reaction occurs (itching, rash, etc.), drug treatment should be stopped immediately.

Possible complications of drug treatment

Due to its rather high toxicity, "Furadonin" can cause a large number of disorders from the internal organs.

In the activity of the respiratory system, the following disruptions can be observed: shortness of breath and cough, pain behind the sternum, frequent attacks of bronchial asthma in patients suffering from this disease.

The gastrointestinal tract can react with dyspeptic syndrome. In extreme cases, hepatitis can develop.

Disruptions in the functions of the nervous system can manifest itself in the form of migraine attacks and dizziness, a sleepy state.

With intolerance to nitrofurantoin, dermatological reactions may occur.

In isolated cases, it is possible to develop arthralgia or superinfection in the urinary organs.

People with anemia, kidney failure, or diabetes mellitus are at risk of developing peripheral neuropathy.

Prohibited drugs when using "Furadonin"

"Furadonin" enhances the side effects of pharmaceuticals that adversely affect the kidneys, so they are not prescribed together.

Medicines that block tubular secretion reduce the antiseptic effect of nitrofurantoin and increase its toxicity.

With cystitis and other diseases of the urinary system, the child needs not only antimicrobial medications, but also diet. You should limit the consumption of sweet and salty. It is also not recommended to eat fried and fatty foods. The diet must include fruits, vegetables and dairy products.

With edema associated with heart and kidney failure, fluid intake should be limited.

What can replace the drug?

The most popular substitutes for "Furadonin" are the following medicines:

• Furagin (tablets);
• "Furazidin" (tablets);
• Furamag (capsules);
• "Furasol" (powder).

All of the above drugs belong to the category of nitrofurans, have a similar effect and can be used to treat the urinary organs in childhood.

"Furagin"

This drug can be prescribed for a child from 1 year of age. It is used for the same diseases as Furadonin. The course of treatment with this drug should not exceed ten days. The duration of therapy can be increased only at the discretion of the attending physician. Along with the medication, it is recommended to take B vitamins to prevent the development of neuritis during medication treatment.

The drug "Furagin"

"Furazidin"

The medicine is permissible for children from 4 years old. In addition to treating urinary tract infections, the drug is used as a local antiseptic for skin damage. The medication has similar contraindications and side reactions. Take the drug after eating food with plenty of water. The duration of therapy is determined by the healthcare professional.

Furamag

A substitute can be prescribed in case of intolerance to the components that make up "Furadonin". The drug belongs to nitrofurans, which have antimicrobial action. The main active ingredient is furazidine. The medicine of this group can be taken from the age of three.

Furamag is prescribed to prevent the development of infectious processes

The drug is taken three times during the day at a dosage of 25-50 mg per kilogram of body weight. The duration of drug treatment can be from 1 to 2 weeks. For preventive purposes, the reception is carried out once.

The drug is not prescribed together with chloramphenicol, ristomyin and sulfonamides, as they can contribute to the disruption of the hematopoietic organs.

If the enzyme glucose-6-phosphate dehydrogenase is insufficient, the medication cannot be taken. Also, it is not prescribed for serious violations of the kidneys or liver.

"Furasol"

The drug is produced in the form of a powder, the main active ingredient of which is furazidine. "Furasol" can be used by children from the age of three. It is prescribed for both prophylactic and therapeutic purposes in order to increase the therapeutic effect of antibiotics.

The drug "Furasol"

The release form of the uroantiseptic makes it possible to use it for the treatment and washing of wounds. In case of hypersensitivity to furazidine, the drug cannot be used. Patients with renal and hepatic insufficiency need a dosage adjustment, which is carried out by a doctor.

Furadonin (Furadonin) tablets - 1 tablet contains nitrofurantoin - 50 mg. Excipients: potato starch, colloidal silicon dioxide, calcium stearate.

Antimicrobial drug of a wide spectrum of action, based on the active substance of a nitrofuran derivative. The tablets have a bacteriostatic and bactericidal effect in urinary tract infections. Furadonin actively suppresses gram-positive and gram-negative bacteria of the species Escherichia coli, Klebsiella spp. , Enterobacter spp. , Proteus spp.

Indications:

Bacterial infections of the urinary tract (pyelitis, pyelonephritis, cystitis, urethritis), prevention of infections during urological operations or examination. Due to the effectiveness and price, the use of furadonin 50mg is quite wide, most often tablets are prescribed for the treatment of cystitis in women.

Furadonin for cystitis - instructions for use

The body very easily assimilates furadonin and the "working" concentration of the active substance in the urine is reached within an hour. Moreover, the level of its concentration in the blood is rather insignificant. Due to their good solubility in biological fluids, the tablets give the urine a darker color, you do not need to be afraid of this.

How to take furadonin for cystitis? According to the instructions for use of the drug, adults take 100-150 milligrams four times a day. The highest daily dose for adults is 600 milligrams, a single dose is 300 milligrams. The specific dosage of furadonin should be prescribed by a urologist after an appropriate examination and determination of the type of bacteria.
The standard course of treatment for cystitis and other urinary tract infections is 7-10 days.

If necessary, the doctor can continue therapy for a few more days (only after a control urine test). During long-term maintenance treatment, the dose of nitrofurantoin should be reduced.

Treatment with furadonin is especially effective in the early stages of cystitis, when the first signs of bladder inflammation appear. Complex therapy is used to treat chronic forms.

It is possible to use the drug for prophylactic purposes - the dosage should not exceed 10 mg per day. It is best to drink at night, after the "last" toilet. Anti-relapse and preventive treatment can last from 3 to 12 months (depending on the type and form of the disease).

For a child under 12 years old, the use of 50 mg furadonin avexim tablets is possible in doses up to 7 mg / kg body weight per day (maximum!), And the daily dose is divided into four doses.

Over 12 years old - 100 mg 2 times a day.

How many furadonin tablets to drink? The doctor will best answer this question after the tests, the recommended doses are indicated above. Furadonin receives numerous positive reviews for cystitis from a large number of patients, especially women, but you should not abuse the drug. Remember that this is a narrow-spectrum antibiotic.

Instructions for the use of furadonin require that when using the drug there are equal intervals between doses. A missed or untimely antibiotic intake reduces its effectiveness. It is recommended to increase the total amount of liquid you drink per day and drink a pill with plenty of clean water.

furadonin Avexim 50 mg is not prescribed for the treatment of purulent paranephritis, prostatitis and pathology of the renal cortex.

Use of Furadonin tablets during pregnancy and lactation

During pregnancy, taking Furadonin increases the risk of developing hemolytic anemia in a newborn. Use is allowed in the last trimester with extreme caution and only as directed by a doctor. Taking Furadonin in the first 12 weeks, when the main vital organs are formed in the embryo, is absolutely excluded.

It is better not to use Furadonin during pregnancy, especially not to self-medicate.

Furadonin penetrates into breast milk, during lactation, as well as children under 1 month of age, the drug is also contraindicated.

Side effects of Furadonin

In case of an overdose of the drug, vomiting and dizziness appear. It is recommended to drink more water to accelerate the elimination of the active substance from the body.
Medicines belonging to the nitrofuran group can cause the following side effects:

• allergic reactions,
• nausea,
• vomiting
• headache and dizziness,
• drowsiness,
• fever,
• dyspnea,
• chest pain and coughing,
• hives;
• quincke's edema,
• itchy skin
• rash,
• anaphylactic shock (very rare),
• drug fever
• arthralgia,
• flu-like symptoms are possible.

While taking the drug, cholestatic syndrome, pseudomembranous enterocolitis may develop. There are signs of pancreatitis, hepatitis. Interstitial changes in the lung tissue develop. Sometimes peripheral neuropathy, broncho-obstructive syndrome occurs (treatment must be stopped!).

Side effects sometimes cause negative reviews about Furadonin from patients, however, when using tablets according to the instructions and under the supervision of a physician, the drug is well tolerated, and mild forms of side effects do not require discontinuation of treatment with Furadonin.

Analogs Furadonin, list of drugs

Antibacterial drugs, Furadonin analogues (nitrofuran derivatives) list:

• Furagin;
• Furazidine;
• Furamag;
• Furasol.
• Furadonin Avexima

Please note - the analogs use the same active ingredient, but these are not exact copies of the drug and their instructions for use are different!

Furadonin contraindications:

Furadonin is contraindicated in persons with hypersensitivity to the drug, chronic renal failure, chronic heart failure II - III stage, liver cirrhosis, chronic hepatitis, acute porphyria, glucose-6-phosphate dehydrogenase deficiency.

Storage conditions:

The drug is stored in a dark, dry place at temperatures below 25 ° C.

Release form of the drug:
Tablets in a pack of 12, 20, 30, 40, 50 pcs.

Furadonin is a drug from the group of nitrofurans that violates the permeability of the cell membrane and protein synthesis in bacteria, providing a bactericidal, bacteriostatic effect.

This drug is effective for the treatment of diseases of the genitourinary system, as it accumulates in high concentrations in the urine and is excreted by the kidneys. Well tolerated with short-term use. The healing effect develops rather quickly and lasts for a long time. It is indicated for the development of an infectious lesion of the prostate in men and for symptomatic treatment of STIs.

The drug is well absorbed from the gastrointestinal tract, crosses the placenta and into breast milk, cerebrospinal fluid, and is excreted by the kidneys. May darken urine. The concentration in the blood at usual therapeutic doses is negligible.

Clinical and pharmacological group

Broad-spectrum antimicrobial agent, nitrofuran derivative.

Conditions of sale from pharmacies

Can buy without a doctor's prescription.

Price

How much does Furadonin cost in pharmacies? The average price is at 110 rubles.

Composition and form of release

The drug is produced in the form of tablets, suspension and powder for internal administration. The tablets are coated with a membrane that dissolves in the intestines. The package contains 12, 20, 30, 40 or 50 tablets.

• The active ingredient nitrofurantoin is a part of Furadonin, colloidal silicon dioxide, potato starch, calcium stearate are also included in the tablets.

Pharmacological effect

Furadonin is a broad-spectrum antimicrobial agent derived from nitrofuran, but not a member of the antibiotic group. Due to the active substance, the drug has a bactericidal and bacteriostatic effect in urinary tract infections. The medicine destroys the membranes of bacteria, inhibits protein synthesis, destroys Escherichia coli, Klebsiella, Enterobacteriaceae, Proteus, Staphylococcus aureus. The agent is well absorbed by the digestive tract, its bioavailability increases with food intake.

According to these instructions, the rate of absorption of the antibacterial agent depends on the size of the crystals (the powder dissolves faster, is absorbed, and concentrates in the urine as quickly as possible). The substance binds to plasma proteins by 60%, is metabolized by the liver and muscle tissues, the half-life is 20-25 minutes. Nitrofurantoin crosses the placental and blood-brain barriers and is excreted by the kidneys.

Indications for use

Furadonin is used for the treatment and prevention of infectious and inflammatory diseases of the urinary tract (caused by pathogens sensitive to the drug):

• pyelitis;
• pyelocystitis;

For prophylactic purposes, Furadonin is prescribed for cystoscopy (examination of the bladder using an optical cystoscope device), catheterization of the bladder (insertion of a special rubber tube into the bladder - a catheter), during urological operations.

Contraindications

According to the instructions for Furadonin, this drug is contraindicated for:

• acute porphyria;
• deficiency of glucose-6-phosphate dehydrogenase;
• pregnancy, lactation;
• hypersensitivity to nitrofurantoin;
• chronic heart failure;
• chronic renal failure;
• cirrhosis of the liver;
• chronic hepatitis;
• under the age of 1 month.

Appointment during pregnancy and lactation

Given the fact that Furadonin crosses the placenta and can have a toxic effect on the fetus, it is contraindicated to take it during pregnancy.

Experimental studies on animals have identified a risk to the fetus. The clinical experience of using Furadonin during pregnancy has not been studied.

Gynecologists sometimes use Furadonin to treat urinary tract infections in women after 12 weeks of pregnancy. In this case, it is necessary to compare the possible risk to the fetus and the therapeutic effect of the use of Furadonin.

Dosage and method of administration

As indicated in the instructions for use, Furadonin tablets are intended for oral administration as an independent bacteriostatic agent or as part of complex therapy for the treatment of urinary tract diseases caused by microorganisms sensitive to nitrofurans. The dose of the drug and the duration of the course of treatment are determined by the doctor purely individually for each patient.

According to the instructions, adult patients and children over 12 years of age are prescribed 50-100 mg of the drug 4 times a day. For children under 12 years of age, a single dose of the drug is calculated based on weight indicators - 5 mg / kg of body weight. The duration of the course of drug therapy is 3-5 days, if necessary, the treatment can be extended up to 14 days under the supervision of a doctor. If during this period the patient does not observe any improvement in his condition or, conversely, deterioration is visible, then taking the pills should be stopped and consult a doctor.

Adverse reactions

During treatment with Furadonin, the following adverse reactions were observed:

1. Drowsiness.
2. Pancreatitis, hepatitis, enterocolitis.
3. Diarrhea, abdominal pain.
4. Vomiting, nausea.
5. Shortness of breath, broncho-obstructive syndrome, cough.
6. Chills, fever.
7. Pain in muscles and joints.
8. Skin rash.
9. Cholestatic syndrome.
10. Changes in blood counts.

With renal failure, the risk of developing peripheral neuropathy increases.

Often during the treatment of Furadonins, diarrhea occurs, which is caused by clostridia. The fact is that the drug is able to change the balance of microflora in the intestine, promoting the growth and reproduction of this type of bacteria. When such a symptom appears, treatment is stopped.

Overdose

When Furadonin is taken orally in high doses, the patient may develop signs of an overdose, which are clinically expressed in an increase in the above-described side effects, impaired renal and liver function, and the development of liver failure.

Treatment of an overdose with the drug consists in washing the stomach, injecting enterosorbents into the patient, carrying out symptomatic treatment if necessary.

special instructions

The risk of developing peripheral neuropathy increases in patients with anemia, diabetes mellitus, electrolyte imbalance, deficiency of B vitamins, severe renal failure.

Nitrofurantoin should not be used to treat diseases of the renal cortex, with purulent paranephritis and prostatitis. Nitrofurantoin is not prescribed in combination with drugs that cause renal impairment.

Compatibility with other drugs

Nitrofurantoin is incompatible with fluoroquinolones.

The simultaneous use of nalidixic acid and antacids containing magnesium trisilicate reduces the antibacterial effect of nitrofurantoin.

With the simultaneous use of drugs that block tubular secretion, reduce the antibacterial effect of nitrofurantoin (by reducing the concentration of nitrofurantoin in the urine) and increase its toxicity (the concentration in the blood increases).

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• insomnia;
• increased sweating;
• loss of appetite;
• vomiting and nausea;
• frequent bowel movements;
• allergic rashes;
• exacerbation of pancreatitis.

• up to 12 weeks of pregnancy;
• glucose deficiency;
• lactating women;
• polyneuropathy;
• fibrosis of the lung tissue;

What helps "Furadonin"

"Furadonin", what helps this bactericidal and bacteriostatic drug? The medication is actively used in urology. The drug "Furadonin" instructions for use prescribe to take with cystitis and urethritis.

The medication is produced in the form of tablets, powder and suspension. The active element of the drug "Furadonin", from which it helps with infections and inflammation of the urinary tract, is nitrofurantoin. Calcium stearate, starch and other substances contribute to the better absorption of the product.

Means "Furadonin", from which it helps with urological diseases, has antimicrobial, bacteriostatic and bactericidal properties. The active element disrupts the reproduction of protein in bacteria. The drug is active against Escherichia coli, shigella, streptococcal, staphylococcal infections and other gram-positive and -negative bacteria. The effectiveness of the drug for the treatment of infections of the urinary tract has been proven, and the resistance of bacteria to the drug develops in rare cases, but resistance is still possible.

The medicine is prescribed for the treatment of the following infectious and inflammatory ailments of the urinary tract:

The medication is prescribed to prevent infections during cystoscopy, surgery in urology, and catheter placement.

The tablets are taken after meals with a large volume of liquid. It is not recommended to bite through the medicine as it is bitter. Adult patients are prescribed 100 # 8212; 150 mg of the drug 3-4 times a day. The maximum daily dosage is 600 mg, you can drink no more than 300 mg at a time.

For infections, use 50 mg of the drug three times a day. For the treatment of urological ailments, the course of therapy is 7 to 10 days. If there is no improvement, the drug is canceled.

Before taking "Furadonin", you must carefully study the instructions. The medicine gives the best result by acting in an acidic environment. Thus, it is recommended to consume protein foods during therapy.

The tablets "Furadonin" help well against cystitis. The therapy regimen involves the use of 3-4 capsules per day. Before taking "Furadonin" for cystitis, you should consult a specialist.

Furadonin tablets are prescribed for children based on body weight. The daily dosage includes 5-6 mg per 1 kg of the child's weight. The received amount of the drug must be taken 4 times a day. For preventive purposes, the volume is determined according to the scheme 1 mg per 1 kg of body weight per day.

Instructions for use prohibit the use of the Furadonin remedy for:

• chronic heart or kidney failure;
• cirrhosis of the liver;
• hypersensitivity to the composition of the drug "Furadonin", from which allergies can begin;
• chronic hepatitis;
• infants up to 1 month old;
• acute porphyria
• during breastfeeding;
• during pregnancy.

The drug "Furadonin", reviews and instructions indicate this, can cause the following negative reactions of the body:

• myalgia;
• asthenia;
• chest pain;
• skin rash;
• nausea;
• fever;
• arthralgia;
• hepatitis;
• allergies;
• shortness of breath;
• eosinophilia;
• headache;
• vomiting;
• peripheral neuropathy;
• anaphylaxis;
• cough;
• angioneurotic edema;
• pancreatitis;
• abdominal pain.

Medicines with a similar composition are not available. The synonym is "Furadonin Avexima", from which it helps according to identical indications. According to the therapeutic effect, the analogues of the drug are: "Furamag", "Furagin", "Furazidin". You can buy Furadonin tablets, the price of which is 60 rubles for 10 pieces of 50 mg each, without a prescription.

There are good reviews about the drug "Furadonin". Patients indicate a high result of the action of the medication. With cystitis, the medicine helps after 2-3 days. The acceptable price of the product is also a positive point. However, patients often complain of headache and nausea after taking the pills.

Many people ask: "Furadonin or Furagin - which is better?" The drugs have similar indications and side effects. Doctors note a milder effect of the analogue. When asked whether "Furadonin" is an antibiotic or not, doctors answer that the drug is not an antibiotic.

Furadonin for cystitis

Cystitis is a fairly common disease that affects both sexes. But the female half of the population is faced with this unpleasant ailment more often, due to the peculiarities of the anatomy of their genitals.

One of the drugs that is still widely used in the treatment of cystitis. is Furadonin. The positive side of the use of Furadonin is that it can fight the most common causative agent of the disease - Escherichia coli.

The drug is well absorbed and at the same time excreted from the body in the urine in a short time. If the drug is used in the recommended dosages, then, as a rule, it does not have a high concentration in the blood.

In addition, the treatment of cystitis with Furadonin tablets is quite inexpensive. This is also an undeniable advantage of this drug.

When should you not drink Furadonin?

With cystitis, Furadonin should not be taken in the presence of diseases such as anuria, oliguria, allergy to this drug. Also, the drug cannot be used if there are problems with the kidneys, liver, or if there are disorders in the excretion of urine from the body. If a woman has had jaundice or is in the ninth month of pregnancy, then you should not use the drug either.

Care should be taken when taking Furadonin in patients with diabetes mellitus, anemia, vitamin B deficiency, electrolyte imbalance, genetic enzyme deficiency, as well as in the presence of any chronic disease. In these cases, a mandatory consultation with a doctor is required about whether to drink or not drink Furadonin with cystitis and how best to do it, or about replacing it with another drug.

According to the instructions, the Furadonin tablets for cystitis should be taken orally with 200 ml of water.

For children, a form of medication such as a suspension is provided. It can be mixed with fruit juice, milk, or plain water. The drug is taken at 50-100 mg four times a day for seven days.

For preventive purposes, the drug is taken once at night, 50-100 mg.

If a child under 12 falls ill, then this medicine for cystitis is prescribed to him at the rate of 5-7 mg of the drug per kilogram of weight (4 doses). For children over 12 years old, the drug is prescribed twice a day, 100 mg for a week.

To improve the absorption of the drug in the instructions for Furadonin, it is recommended to take tablets with meals.

Side effects of Furadonin

When taking this medication, various side effects can occur, which can be expressed in:

• chills, fever, body aches;
• shortness of breath, diarrhea, dry cough, sudden chest pain or discomfort;
• peeling, rash, pallor of the skin;
• tingling, numbness, or pain in the limbs;
• abdominal pain, nausea, yellowing of eyes and skin, loss of appetite;
• headache, eye pain, confusion, blurred vision, tinnitus;
• vaginal discharge and itching in the genitals.

If Furadonin is taken in doses higher than those recommended by the doctor, then this can cause an overdose of the drug, which manifests itself in the form of vomiting. In such situations, patients are shown: drinking plenty of fluids and hemodialysis.

Special instructions for Furadonin

Only a doctor can prescribe the drug. After recovery, which is demonstrated by appropriate tests, Furadonin must be drunk for at least seven more days under medical supervision.

When using this medication for a long period, the functioning of the kidneys, liver, and lungs should be monitored.

Inside, drinking plenty of water, adults - 0.1-0.15 g, 3-4 times / day; children - at the rate of 5-8 mg / kg / day, the daily dose is divided into 4 doses. Higher doses for adults: single - 0.3 g, daily - 0.6 g.

For acute infections urinary tract treatment duration - 7-10 days.

Preventive, anti-relapse treatment continues, depending on the nature of the disease, from 3 to 12 months. The daily dose in this case is 1-2 mg / kg.

Nausea, vomiting, allergic reactions (lupus-like syndrome, arthralgia, myalgia, anaphylaxis, chills, eosinophilia, rash), dizziness, headache, asthenia, nystagmus, drowsiness, interstitial changes in the lungs, broncho-obstructive syndrome, fever in the chest, cough , hepatitis, cholestatic syndrome, peripheral neuropathy, pancreatitis, pseudomembranous enterocolitis, rarely - abdominal pain, diarrhea.

Contraindications for use

chronic renal failure;

heart failure II-III degree;

cirrhosis of the liver;

chronic hepatitis;

deficiency of glucose-6-phosphate dehydrogenase;

acute porphyria;

lactation period;

children under 3 years old.

Application during pregnancy and lactation

The use of the drug during pregnancy and during breastfeeding is contraindicated.

Application for violations of liver function

The use of the drug in patients with liver cirrhosis and chronic hepatitis is contraindicated.

Application for impaired renal function

The use of the drug in patients with chronic renal failure is contraindicated.

Application in children

The use of the drug for children under 3 years of age is prohibited.

Children over 3 years old the dose is prescribed at the rate of 5-8 mg / kg / day, the daily dose is divided into 4 doses.

The effect of the drug on the performance of potentially hazardous activities that require special attention and quick reactions

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions (when dizziness and drowsiness appear).

Treatment: taking large amounts of liquid leads to an increase in the excretion of the drug in the urine. Dialysis is effective.

The simultaneous use of nalidixic acid and antacids containing magnesium trisilicate reduces the antibacterial effect. Incompatibility with fluoroquinolones. Medicines that block tubular secretion reduce the antibacterial effect (by reducing the concentration of nitrofurantoin in the urine) and increase the toxicity (the concentration in the blood increases) of the drug.

Terms of dispensing from pharmacies

The drug is available by prescription.

Storage conditions and periods

The drug should be stored in a dry, dark place and out of reach of children at a temperature not exceeding 25C. Shelf life is 4 years.

Do not use the drug after the expiration date.

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Reading time: 6 minutes

Furadonin is a drug of the nitrofuran group with antimicrobial activity due to the ability to disrupt the permeability of the cell wall and protein synthesis in the bacterial cell.

The active ingredient, the international non-proprietary name of the drug, is nitrofurantoin. Furadonin is prescribed for cystitis and other infections of the lower urinary tract.

1. Indications and dosages

2. Application for chronic cystitis

3. Spectrum of activity of the drug Furadonin

Table 1 - Sensitivity of E. Coli isolated during MEP infections to antibacterial drugs (I. S. Palanin, 2009)

Monural - powder for the treatment of acute and chronic cystitis

4. Place of nitrofurantoin on the pharmacological market

1. 6 Other severe reactions (neurological and hematological disorders) were even less common, in about 0.0007% - 0.0004% of cases.

There is also a third form of nitrofurantoin - nitrofurantoin MV (modified release), consisting of macrocrystals and monohydrate. It has a gel-like structure and is released even more slowly.

The incidence of adverse events in these studies is 5 to 16%. This is comparable to the drugs of other groups, and sometimes even lower.

Sharp pains in the lower abdomen, frequent urination, especially disturbing at night and accompanied by cramps, are symptoms of cystitis, familiar to almost every adult, are especially disturbing for women. Inflammation of the bladder requires immediate treatment. Furadonin for cystitis is an effective remedy in the fight against microbes that cause inflammation.

Cystitis is a pathology of the urinary system that does not have gender and age restrictions, although it is more common in the fairer sex.

It has been proven that cystitis is a microbial disease caused by E. coli, staphylococcal infection, and sexually transmitted pathogens. At the first signs of cystitis, it is recommended to take furadonin, which is able to fight pathogens, is well absorbed by the body and quickly excreted by urine.

The main active ingredient of Furadonin from cystitis is nitrofurantoin, which belongs to synthetic antimicrobial agents and is excellent for treating infections of the urinary system.

It is produced in tablet form, which allows the drug to be absorbed into the bloodstream and excreted by the kidneys within 4 hours. Nitrofurantoin, being in the lymphatic system and reaching the focus of infection, blocks the action of microbes, disrupting the exchange of bacterial cells, leading to the destruction of pathogenic microorganisms.

The effectiveness of the drug confirms the selective effect on gram-positive and gram-negative bacteria (for example, Shigella sonnei (shigella), Staphylococcus saprophyticus (saprophytic staphylococcus), Escherichia coli (Escherichia coli), Enterobacter spp (enterobacter), Proteus spp (proteiella) spp. The advantage of the drug over antibiotics is to preserve the intestinal microflora.

The growth of pathogenic microorganisms is stopped due to an active medicinal effect on the urinary system, increasing the degree of body defense and improving the immune system.

The positive therapeutic effect of furadonin on the kidneys, urethra, urinary ducts, and also the external female genital organs has been proven. Actively acting as an antiseptic, nitrofuratonin promotes the healing of internal lesions (trauma, cracks, ulcers, fistulas).

When starting treatment with furadonin, the patient should make sure in which cases the use of the drug is indicated.

Health care providers prescribe furadonin in the following cases:

• treatment of genitourinary infections such as cystitis, pyelonephritis, pyelitis and urethritis;
• therapy of chronic pathology of the bladder;
• a preventive measure for urological and gynecological examinations (cystoscopy, catheterization, minimally invasive urological operations).

Before using the drug, it is mandatory to consult a specialist who will select an individual treatment regimen.

Different dosage of furadonin assumes taking into account age characteristics, pathology features and causes of the disease.

In order to calculate how to take a single dose of the drug, you need to remember that 5-8 mg is shown for 1 kg of body weight. Then everything is simple: for example, your weight is 62 kg, you must multiply it by 8 mg and divide by 100. It turns out 4.96 mg. Is your single dose. Considering that the tablets contain 50 - 100 mg, then at one time you are shown 1 tablet of 50 mg or half of 100 mg of furadonin.

In the instructions for use for cystitis, there are methods of administration calculated by doctors:

• adults (over 18 years old) three times, 1-2 tablets;
• children over 12 years old 2 times a day, 1-2 tablets;
• for children under 12 years old, four times a ½ tablet.
• pregnant women from 13 weeks to 0.1-0.5 mg four times a day.

The duration of the course is on average 1-2 weeks and depends on the attending physician.

The dosage of drugs and the duration of the course also depends on the stage of the course of the disease:

1. Acute cystitis is treated for up to 10 days. Take 50 mg of furadonin every 6 hours (for adults).
2. The chronic course of inflammation of the urinary system of cystitis is stopped by a single intake of 50-100 mg of nitrofurate. Therapy is individual, long-term (up to 3 months) is prescribed by a doctor.
3. To prevent relapses, use 100 mg of the drug at night.

For the treatment of cystitis with furadonin in women and men, in the first three days of the disease, take four times 100 mg of the drug. Timely started treatment after the first dose of the drug reduces pain and normalizes urination, acting instantly.

It is obligatory to consult your doctor before starting taking furadonin. If the course of treatment is started, then you should take a responsible attitude to taking furadonin, trying not to miss taking the drug and observing the same time interval. Do not take two doses at the same time to avoid side effects.

Pregnant women need to use the medicine with extreme caution, since fetal intoxication is possible. If taking nitrofurate during lactation, refrain from breastfeeding.

Take furadonin tablets with plenty of water. It is recommended to increase the amount of drinking during the treatment period.

Actively acting, showing a therapeutic effect, the drug begins after two to three days.

Tablets for cystitis Furadonin is well tolerated by the majority of patients. There have been cases of side effects:

• pain in muscles, chest area, head;
• insomnia;
• increased sweating;
• loss of appetite;
• vomiting and nausea;
• frequent bowel movements;
• allergic rashes;
• exacerbation of pancreatitis.

If one of the signs is found, you should stop taking nitrofurate and seek the advice of a specialist.

In order to prevent the manifestation of the above symptoms, you should pass a test for the tolerance of the drug and follow the instructions: take the medicine with meals or after, drinking plenty of water or milk.

The instructions for the use of furadonin for cystitis indicate the prohibition of the use of the drug in the following cases:

• up to 12 weeks of pregnancy;
• newborns of the first month of life;
• chronic pathologies of the kidneys and liver (hepatitis, cirrhosis, porphyria);
• heart failure 2.3 degrees of severity;
• glucose deficiency;
• lactating women;
• polyneuropathy;
• fibrosis of the lung tissue;
• increased drug sensitivity.

Elderly people should take Furadonin for cystitis with extreme caution. The drug is incompatible with alcohol.

Modern pharmacology has a wide range of drugs indicated in the treatment of inflammation of the urogenital area. Long-term studies and patient reviews prove the effectiveness of furadonin in cystitis.

The advantages of the drug include:

• unlike antibiotics (amoxicillin), it does not suppress the immune system;
• nitrofurantoin, which is the active ingredient of furadonin, disrupting the protein synthesis of pathogenic microorganisms, simultaneously activates leukocyte activity;
• positive effect on the adsorption capacity of the liver and spleen, improving the binding properties of blood;
• the recommended dosage of furadonin is not addictive;
• a small dose of the drug settles in the blood, unlike antibiotics;
• adaptation of bacteria to nitrofuran in the treatment of cystitis and other urinary infections was not noticed, which allows the drug to be used repeatedly even in case of relapses;
• has no structural analogs;
• available to everyone without exception due to the optimal price-quality ratio;
• few side effects and contraindications in comparison with antibacterial agents for the treatment of cystitis;
• treatment of children over 1 month is possible;
• simultaneous fast bacteriostatic and bactericidal effect.

The above advantages of the drug make it possible to use it to treat people with a sufficient number of chronic diseases.

It has been clinically proven that when interacting, some drugs negatively affect Furadonin, reducing its therapeutic effect. These include:

• acidity lowering agents (gastal, almagel);
• antacid preparations containing magnesium trisylact and nalidixic acid;
• fluoroquinolones (ofloxacin, ciprofloxacin, levofloxacin);
• drugs that block tubular secretion (phenylbutazone);
• sulfinpyrazone and probenecid reduce the release of furadonin.

The use of Furadonin together with the listed drugs increases its concentration in the blood, increasing the toxicity of the drug, which can provoke side effects.

The main active substance of furadonin, nitrofurantoin (or nitrofuran), is unique and has no analogues.

Medicines such as furamag, furasol, furazidin, furagin are considered similar in their therapeutic effect. They are derivatives of nitrofuran.

Experts advise using derivatives for cystitis only in the case of a urine culture test for antibiotic sensitivity. A significant disadvantage of drugs similar in the mechanism of treatment for cystitis is their inability to kill bacteria (unlike Furadonin). They only stop their growth and reproduction. In any case, the decisive word in the appointment of drugs for cystitis will be the word of a urologist, gynecologist or therapist.

Patients who have experienced the effect of furadonin on themselves note its positive properties: rapid onset of relief (an hour after administration), convenient form of use (the pill can be drunk from anywhere), availability (you can always buy at a pharmacy at a "pleasant" price) , the possibility of treating children and pregnant women.

Among the negative aspects, only side effects (vomiting, dizziness, headaches) were noted, but they are recorded in rare cases.

Please note: Furadonin is a toxic drug, so it should be taken after a medical appointment.

Reading time: 6 minutes

Furadonin is a drug of the nitrofuran group with antimicrobial activity due to the ability to disrupt the permeability of the cell wall and protein synthesis in the bacterial cell.

The active ingredient, the international non-proprietary name of the drug, is nitrofurantoin. Furadonin is prescribed for cystitis and other infections of the lower urinary tract.

Independent and uncontrolled intake of antibacterial agents leads to an increase in the resistance of the uropathogenic flora, therefore, this drug should not be taken without the advice and recommendation of the attending physician.

Today, Furadonin is used directly for the treatment of uncomplicated cystitis, as well as for the prevention of bladder infection during cystoscopy and catheterization.

It reaches therapeutic concentrations only in the lower urinary tract, which makes it impossible to use it for pyelonephritis or prostatitis.

The scheme for taking Furadonin for acute uncomplicated cystitis according to the Russian clinical guidelines of 2016 and the official instructions for use: 100 mg tablets 3-4 times a day, orally, with plenty of water. The duration of treatment is 5-7 days.

The bioavailability of the drug is high (more than 50%), and the absorption rate is fast. Taking Furadonin with food increases the bioavailability of the drug and increases its effectiveness.

Macrocrystalline nitrofurantoin (Uvamin retard, not registered in the Russian Federation) is used in a dosage of 100 mg 2-3 times a day.

This is due to the fact that the macrocrystalline form has a sustained release of the active substance. Microcrystals do not appear in any of the foreign recommendations, and on the Russian market, on the contrary, the macrocrystalline form is not registered.

Antibiotics and regimens used to treat cystitis in women, men, children, and pregnant women

In chronic recurrent cystitis, antibiotic prophylaxis using Furadonin is possible (EAU 2015).

The regimen for taking the drug for the prevention of exacerbations is as follows: take 50 mg tablets once a day (the duration of the course is selected by the attending physician individually, usually 3-6 months).

Antibiotic prophylaxis for chronic cystitis should not be self-administered. The use of antibiotics is an extreme measure when all other types of preventive measures have been ineffective (herbal uroseptics, Uro-Vaxom, etc.).

Before starting antibiotic prophylaxis, it is imperative to obtain a negative bacterial culture of urine.

It must be remembered that long-term use of Furadonin increases the likelihood of severe adverse reactions.

Tablets and other medicines for the treatment of cystitis in women and men

The most common (in 65-80% of cases) causative agent of acute cystitis is Escherichia coli (E. Coli). This microorganism is sensitive to many types of antibiotics, however, due to the frequent and uncontrolled prescription of antibacterial agents in medical practice, E. coli was able to develop drug resistance to most of them.

The widespread use of antibiotic resistance today significantly limits the choice of agents for the treatment of cystitis.

Furadonin (nitrofurantoin) is one of the few antibiotics active against Escherichia coli, as well as Enterobacter, Klebsiella, Staphylococcus and Streptococcus.

The resistance of Escherichia coli to nitrofurantoin is quite low and fluctuates in Russia within the range of 1.2-4.3%, depending on the sample of patients.

Table 1 - Sensitivity of E. Coli isolated during MEP infections to antibacterial drugs (I. S. Palanin, 2009)

At the same time, almost all strains of Proteus, Pseudomonas aeruginosa and actinobacteria are resistant to nitrofurantoin (according to the EUA data from 2011).

These microorganisms are rarely the causative agents of acute cystitis, but one should not forget about the possibility of inflammation due to polymicrobial associations.

Monural - powder for the treatment of acute and chronic cystitis

The first drugs of the nitrofuran group appeared on the pharmacological market in the 1940s.

Nitrofurantoin was approved by the FDA (USA) in 1953 as the first line of treatment for uncomplicated urinary infections.

It has been actively used to treat acute cystitis for almost two decades, but with the development of pharmacological production and the emergence of drugs such as trimethoprim / sulfamethoxazole, fluoroquinolones, and B-lactam antibiotics, its popularity declined sharply.

Nitrofurantoin is one of the oldest antimicrobial drugs, however, the resistance of E. coli to it is still quite low.

This slow development of drug resistance is associated with the presence of not one, but several mechanisms of action. That is why bacteria should develop not one, but several mutations, which is evolutionarily more complicated.

By the early 2000s, increasing resistance to fluoroquinolones and B-lactams led to renewed interest in nitrofurantoin.

According to modern aspects of the choice of antibiotics, nitrofurans, including Furadonin, can be taken for cystitis as first-line drugs.

In domestic (2016) and European (2015) urological recommendations, nitrofurantoin is one of the three drugs of choice for the treatment of acute cystitis (evidence 1a, recommendation A).

Despite the fact that nitrofurantoin was one of the first available antibiotics for the treatment of urinary tract infections, the drug underwent serious clinical trials two decades after its release (in 1970).

The purpose of these studies was not to study nitrofurantoin, but to evaluate the effectiveness of new antibiotics in comparison with the “gold standard” of that time.

In total, in the 70s, 24 randomized studies were conducted that proved the effectiveness of nitrofurantoin and new generation antibiotics, which led to the displacement of the “outdated” Furadonin into the background.

The second peak of randomized clinical trials of nitrofurantoin occurred in 1990-2000. They have demonstrated high efficiency of the 5-7 day course. However, it has been found that the drug is ineffective if taken for three days.

Thus, in an open controlled study by Hooton et al (1995), three- and seven-day courses (in a dosage of 100 mg 4 times a day) were compared. 6 weeks after the end of the intake, the effectiveness of a 3-day course of nitrofurantoin was only 61%. At the same time, the effectiveness of the five- and seven-day courses varied in the range of 80-92%.

To date, despite the existence of many randomized trials that included male patients, baseline demographics have not been disclosed and the results have not been disaggregated by sex. Thus, the pharmacological efficacy of Furadonin in men cannot be assessed.

Nitrofurantoin entered the drug market at a time when the requirements for the reliability and methodology of antibiotic development were not yet clearly regulated. Despite its widespread use, there is still uncertainty about its likely toxicity.

A comprehensive meta-analysis of studies on nitrofurantoin revealed the following:

1. 1The main adverse events with nitrofurantoin were symptoms of gastrointestinal dysfunction. Moreover, the toxicity of the drug was mild and quickly reversible. Symptoms resolved quickly when the drug was discontinued.
2. 2None of the analyzed studies recorded serious and irreversible effects with a duration of admission less than 14 days.
3. 3 Rare, severe and indeed dangerous side effects of nitrofurantoin (pulmonary fibrosis, hepatotoxicity, autoimmune disorders) have been reported in patients treated with the drug for many months and years.
4. 4 Timely diagnosis of severe complications and autoimmune disorders, as well as the timely withdrawal of the drug led to a rapid reverse development of symptoms and recovery.
5. 5The estimated incidence of pulmonary fibrosis and liver damage with long-term use was 0.001% and 0.0003%, respectively, which is not higher than that of other antibiotics in this group.
6. 6 Other severe reactions (neurological and hematological disorders) were even less common, in about 0.0007% - 0.0004% of cases.

Based on this meta-analysis, it can be concluded that Furadonin's toxicity is quite low, if the duration of administration is not more than 14 days.

As mentioned above, nitrofurantoin is microcrystalline (Furadonin, Furadonin Lect) and macrocrystalline (Uvamin retard).

The earliest (1983) studies of nitrofurantoin were aimed at comparing the toxic effects when using the micro- and macrocrystalline form of the drug. They showed a 50% reduction in the risk of adverse reactions when using the macrocrystalline form.

When using the macrocrystalline form of nitrofurantoin, the risk of developing adverse reactions is lower, and the effectiveness of treatment is higher. This is due to the slow release of the drug, unfortunately, this form of antibiotic is not available in the Russian Federation.

The microcrystalline form, that is, Furadonin, is rapidly absorbed, which often leads to gastrointestinal disorders.

There is also a third form of nitrofurantoin - nitrofurantoin MV (modified release), consisting of macrocrystals and monohydrate. It has a gel-like structure and is released even more slowly.

In almost all foreign clinical trials, only macrocrystalline nitrofurantoin was used. In most studies, the drug was recommended to be drunk for 5-7 days, rarely for 10-14 days.

The incidence of adverse events in these studies is 5 to 16%. This is comparable to the drugs of other groups, and sometimes even lower.

The overly widespread use of Furadonin is unjustified, despite its high efficiency. This is due to the increased risk of adverse events from its use, dysfunction of the gastrointestinal tract and hepatotoxicity.

This drug should not be administered in conjunction with fluconazole (Flucostat), as the toxic effect on the liver increases. Contraindicated in cirrhosis, liver failure and deficiency of G-6-FDG (glucose-6-phosphate dehydrogenase).

Furadonin effectively affects even resistant microorganisms; its disadvantage is the need for a longer course compared to other first-line drugs.

Previously, Furadonin was one of the antibiotics of choice for the treatment of acute cystitis during pregnancy. With the advent of fosfomycin trometamol (Monural, Urofoscin) on the pharmaceutical market, the drug was relegated to the background.

Today it is used for asymptomatic bacteriuria in pregnant women and has been moved to the group of alternative agents for acute inflammation of the bladder (MONIKI 2014).

The safety of the drug during pregnancy has been proven in many population studies, it belongs to the FDA safety class B, but its use is allowed only in the second trimester. It is categorically contraindicated in the later stages due to the high risk of hemolytic complications in the fetus.

Cystitis is a rather unpleasant disease, it can occur unexpectedly and causes a person terrible discomfort. Causes frequent urination, pain in the lower abdomen and other unpleasant symptoms. One of the most effective drugs that eliminate the disease is "Furadonin". Reviews for cystitis about him are very different. Some felt relief after the first pill, others suffered from side effects.

For a long time and reliably used in the treatment of diseases of the genitourinary system, the drug "Furadonin". The release form of the medicinal product is tablets. Contains active ingredient nitrofurantoin. Produced in a concentration of 50 or 100 mg.
Additional components in the composition of the drug are:

• potato starch;
• aerosil;
• stearic acid;
• polysorbate-80.

The medicine is produced in the form of tablets, which have a flat-cylindrical round shape. Bevelled. Painted yellowish. Packed in a blister of 10 pieces. A cardboard box contains from 10 to 50 pieces.

"Furadonin" refers to antimicrobial agents. Its shelf life is four years, after which it cannot be used. The product is stored in a dry and ventilated room, at a temperature of no more than +25 C.

The high efficiency of the drug "Furadonin" for cystitis is noted. The medication belongs to antimicrobial agents. Derived from the nitrofuran group. It is used in the treatment of infectious diseases of the urinary system. The drug blocks protein synthesis that occurs in pathogenic bacteria and disrupts the permeability of the membranes of diseased cells. Its activity is observed both against gram-negative bacteria and against gram-positive microorganisms. The drug does not affect the bacteria Enterococcus spp., Acinetobacter spp., Pseudomonas aeruginosa. Pills do not work on Candida mushrooms either.

The drug is absorbed from the gastrointestinal tract. The bioavailability of the drug is 50%. Food intake increases the degree of its bioavailability. The drug interacts with blood proteins by 60%. Metabolized in the liver and muscles. The half-life lasts about 25 minutes.

The agent can penetrate the placenta and into breast milk. It is 100% excreted by the renal system, including 50% of the drug excreted unchanged.

Medication is prescribed in several cases. These are diseases of the urinary system caused by pathogenic bacteria. Among such ailments are pyelonephritis, cystitis, pyelitis and urethritis. Prescribe tablets for prophylactic purposes, before surgical urological intervention, as well as when examining the urinary tract. Has strictly defined indications "Furadonin" and in other cases its use is highly undesirable.

Recommended to take tablets "Furadonin" instructions for use for cystitis, but not all patients. So, it is prohibited to take the drug to patients with hypersensitivity to the constituent substances of the drug, in particular to nitrofurans or to nitrofurantoin. You can not take the medicine for people with severe kidney disease, kidney failure and oliguria.

The medicine is prohibited for children under the age of three, as well as for pregnant and lactating women. In the latter cases, there is a risk of hemolytic anemia in the newborn child and fetus, since the erythrocyte system is not yet mature enough. Contraindication to taking pills is chronic hepatitis and cirrhosis of the liver. Do not prescribe drugs for chronic heart and glucose-6-phosphate dehydrogenase failure. Do not prescribe "Furadonin" for porphyria, which is in the acute stage of development.

Cystitis tablets are taken orally. Since food increases the bioavailability of the drug, it is advised to take it during meals with water.

If there are no other medical prescriptions, then adults with infectious diseases of the urinary tract, proceeding without complications and being in the mild and moderate stages, are prescribed 50 mg 4 times a day. How much to drink "Furadonin" in this case? Typically, a therapy course lasts a week. If the disease is in a severe stage of development, is repeated, then it is recommended to drink 100 mg 4 times a day. The course of treatment is 7 days.

If the drug is used in supportive care, then it should be taken once a day at a dosage of 50 mg to 100 mg.

With surgical urological intervention and examination of the urinary tract, the medication is taken four times a day at a dose of 50 mg. In this case, the tablets are consumed on the day of the urological procedure and for three days after these events.

In childhood - from 3 years old - for diseases of the urinary tract, which are infectious and proceed without complications, the drug is prescribed at the rate of 3 mg per kilogram of the child's weight. The calculated dosage is consumed 4 times a day. The course in this case lasts about 7 days. For the prevention of urological diseases, the drug is drunk at the rate of 1 mg per kilogram of weight and only once a day. A suspension is recommended for children weighing no more than 25 kg.

During the use of the drug "Furadonin" in the treatment of cystitis, side effects sometimes appear. Among them are nausea, vomiting, allergies. Sometimes patients experience dizziness, drowsiness, headache, asthenia, body chills, anaphylaxis, skin rashes, eosinophilia.

Among the negative reactions, there is broncho-obstructive syndrome, hepatitis, cough. Pain in the chest, pancreatitis, diarrhea were identified. When taking the drug, cyanosis and pseudomembranous enterocolitis were noted. There were cholestatic syndrome, optic neuritis and peripheral neuropathy. In some cases, abdominal pain occurs.

Tablets for cystitis "Furadonin" are taken strictly according to the instructions, otherwise an overdose may occur. Vomiting is a symptom of this condition. In this case, it is recommended to drink as much liquid as possible. Dialysis is used.

The drug "Furadonin" is canceled at the first symptoms of peripheral neuropathy, that is, when paresthesia occurs. In this case, the development of this effect can cause it can be very dangerous.

You cannot take pills if the diagnosis is not established, but there are certain abnormalities in the work of the lungs, liver, and there are also problems from the nervous and vascular system. If at least minor symptoms of lung damage appear while taking the drug, then the drug is stopped.

During therapy with "Furadonin" you need constant monitoring of the pulmonary system. This is especially true for the elderly and patients on long-term treatment with the drug "Furadonin".

Side effects from the gastrointestinal system will be minimal if the medication is taken together with food or milk. Reducing the dosage will help reduce the likelihood of side effects.

The tablets cause the urine to turn yellow or brown. Patients using "Furadonin" in therapy sometimes show false-positive symptoms to determine the glucose level in the urine.

Adverse reactions from the gastrointestinal tract can be minimized by taking the drug with food, milk or by reducing the dose.

It is strictly contraindicated to use the drug during pregnancy and when breastfeeding. It is still not advised to prescribe medicine to children under 3 years of age.

With caution, "Furadonin" is prescribed to patients suffering from diabetes mellitus, lack of B vitamins.

Caution should be observed in persons with diabetes mellitus, anemia, electrolyte disturbances, deficiency of B vitamins, since the neurotoxic effect of the drug may increase.

"Furadonin" is forbidden to use for liver pathologies. Do not prescribe pills for purulent prostatitis and paranephritis. It is forbidden to use the medicine if the patient has impaired renal function. Especially - for the treatment of parenchymal infection of one non-functioning kidney. The drug may affect the ability to drive vehicles and work with moving machinery, as there is a possibility of drowsiness or dizziness. When treating with "Furadonin", it is forbidden to control a machine and various complex moving mechanisms.

Unfortunately, Furadonin has no complete structural analogs. But this drug can be replaced with drugs, the mechanism of action of which is similar to "Furadonin". These medicines include nitrofuran derivatives, these are:

• Furamag.
• "Furazidin".
• "Furagin".
• "Furasol".

"Furagin" is the closest analogue of "Furadonin" in composition. The indications and contraindications for use of these drugs are the same. Hence the question invariably arises, which is better for cystitis "Furagin" or "Furadonin". Both drugs are nitrofuran derivatives. Both have antimicrobial properties. They come from the same group. Medicines act on the body in the same way and have similar indications for use.

Despite the similarity of drugs, patient reviews still note that "Furagin" in some cases is a more effective drug. This is due to the fact that it has less negative impact. Patients say that it is a milder drug than Furadonin. Despite this, you should not make a choice on your own, but it is better to seek medical advice from a doctor, especially since these drugs are quite old and are less and less used in urological practice. They were replaced by more modern drugs such as "Nolitsin", "Norbactin" and others. In any case, the choice of the medicine must be made by the doctor, and the patient must only follow his prescriptions.

The drug "Furadonin" is distinguished by its democratic cost. So, 50 tablets of 50 mg each will cost 60 rubles, 10 tablets of the same dosage will cost about 40 rubles, and the price of 20 pills of 100 mg is 80 rubles. Buying drugs on the Internet will cost a little more.

The drug "Furadonin" reviews for cystitis has both positive and negative. Those people who have been helped by the medication note that the pill works almost immediately. The medicine has an affordable price, and not so many pills are needed for a course. In the case of cystitis, many people drink these pills and do not think about changing them. In addition, almost all of them note that with this medicine you can forget about cystitis for a long time.

There are also negative reviews. With cystitis, "Furadonin", in principle, according to some, can be taken, since it is quite effective, but many people are afraid of its strong side effects, which some of them have experienced. Among them are nausea, severe headaches and pain in stomach area, dizziness. Moreover, negative symptoms directly depend on the frequency of drug use. The more often people used it, the worse they felt. Many people associate this phenomenon with the high toxicity of the drug. And they note that one must be more careful with these drugs. And if possible, then it is advised to choose a more gentle remedy.

In general, the drug has worked well. Nevertheless, in order not to harm, but to help yourself get rid of cystitis, you need to follow one rule: the medicine should be prescribed only by a doctor, and the course of treatment for them should be at least seven days.

Each disease has its own characteristics. So, cystitis is very often chronic. For this reason, everyone strives to find a treatment that is not only effective, but also affordable in terms of price. Furadonin tablets for cystitis in a dosage of 50 or 100 mg are perfect for these requirements.

Furadonin is an affordable and effective agent against cystitis

The drug is effective against pathogens such as staphylococci, gram-positive bacteria and E. coli. They are the most common cause of inflammation. It is possible to take Furadonin for cystitis in men, women and even children from the first days of the disease, as well as with an increased risk of relapse against the background of a chronic course of the pathology.

The active component of Furadonin from cystitis is the derivative Nitrofurantoin. Due to this, the drug belongs to antimicrobial agents used in the detection of certain bacteria. It is used in the presence of pathogens such as isherichia, enterobacter, protea, and so on. In more rare cases, the drug can be used for enterococci, staphylococci and aerobes.

Immediately after entering the body, the active component of the drug is absorbed by almost 95%, while its concentration in the blood is insignificant. The drug dissolves easily in all biological fluids. This explains the change in urine color to a darker one during therapy.

The drug is highly digestible and helps with concomitant diseases

The medicine is available in the form of tablets with a yellow color. They taste bitter, but due to their small size, they are easy to take with water. For children, you can pre-mix the tablet with sweet syrup or a spoonful of jam.

The drug can be used not only for cystitis, but also for such concomitant pathologies as pyelitis, urethritis, nephritis, and so on. It is especially beneficial to take Furadonin 50 mg after catheterization or surgery to prevent inflammation.

The tablet form of the drug makes it easily digestible. Immediately after the tablet enters the digestive tract, it is absorbed by the intestinal villi and after 3-4 hours it begins to act, even if only 50 mg was taken. As a result, the active substance enters the lymphatic system and through it reaches the focus of infection. Due to this, infection of other organs is excluded.

At the same time, the drug disrupts the process of transferring bacterial cells with hydrogen, metabolic processes change, which causes the destruction of pathogenic cells.

The drug is also able to improve kidney function

An important advantage of the drug is the selective effect on pathogenic cells, which excludes the violation of microflora. This is the main difference from antibiotics widely used in the treatment of cystitis in women and men.

During the use of Furadonin from cystitis, there is an improvement in the condition of neighboring organs: kidneys, urethra, ducts, and so on. In addition, inflammatory processes of the external genital organs in women are simultaneously eliminated.

Due to the acceleration of wound healing, the medicine can be taken for cystitis caused by catheterization, trauma, and in the presence of ulcers and fistulas.

To eliminate cystitis in women and men in the first days of the disease, it is recommended to take 100 mg of the drug at a time up to four times a day. He begins to act in a couple of hours, which immediately has a positive effect on the general condition of the patient. If you start treatment on time at the first symptoms of the disease, after the first pill there will be a noticeable decrease in pain and normalization of urination.

How many days the treatment should continue will be determined only by the doctor. The absence of symptoms does not in any way indicate the complete elimination of inflammation and is not a reason for discontinuing the drug.

Furadonin is also indicated for the treatment of children

For children, the drug is prescribed at the rate of 5 mg per kilogram of the baby's body weight. The resulting dosage should be divided into 3-4 doses. The duration depends on the severity of the illness.

Due to the specific composition, treatment with Furadonin in some cases is more effective. This is explained by the fact that the active components act on certain pathogens and, if they are detected, it is recommended to use this particular drug. In addition, by prescribing the drug to children, you can reduce the risk of developing a chronic form. The same applies to women, who often have cystitis worsening while carrying a child.

If you drink the drug in the indicated dosage and do not exceed it, no side effects occur. In rare cases, the following symptoms are noted:

• allergic reaction;
• nausea and vomiting;

Taking the drug may cause dizziness.

In order to exclude negative consequences, it is enough to find out from the attending physician how many tablets you can drink during the day and how long you need to continue treatment. Please note that Furadonin is available in both a 50 mg dosage and a 100 mg dosage. Accordingly, the frequency of administration and the number of tablets will differ.

If abnormalities appear, it is important to see a doctor and stop treatment. Taking the drug with meals will help reduce the likelihood of side effects. In addition, it is prohibited to consume alcoholic beverages until the treatment is over. Furadonin is used in the treatment of cystitis in men and women, and it is also often prescribed to children. But while carrying a baby, it is recommended to choose another drug.

Despite the minimal contraindications, the drug is not prescribed for pregnant women

Benefits of the drug

Even if you take Furadonin for a long time with cystitis at a dosage above 50 mg, there is no violation of immunological resistance. This makes the drug especially beneficial against the background of other antibiotics. In addition, the drug, on the contrary, helps to strengthen the defenses by stimulating the action of leukocytes. Also, the drug has a positive effect on the adsorption capacity of the liver and spleen, and also improves the binding properties of blood.

Compared with antibiotics, when using this drug, the dosage can be reduced, since there is no addiction and adaptation to the active ingredients. This makes Furadonin especially beneficial in the treatment of chronic cystitis in men and women, as well as with reduced immunity. The drug copes with the acute process especially quickly, regardless of the severity of the course.

Due to the large number of advantages, the drug can be used to treat people with a large number of chronic pathologies, and it can also be given to children.

You can find out about other drugs that can help with cystitis below: