Wobenzym as an independent preparation. Wobenzym: instructions for use

300 units chymotrypsin (moreover pancreatin is presented in units (U) of the European Pharmacopoeia, and the remaining ingredients in units (U) of the International Pharmaceutical Federation).

Additional components: stearic acid, lactose, talc, corn starch, purified water, magnesium stearate, colloidal silicon dioxide.

Shell composition: povidone, shellac, sucrose, copolymer of methyl methacrylate and methacrylic acid, vanillin, talc, white clay, titanium dioxide, macrogol 6000, carnauba wax, triethyl citrate, bleached wax, dyes (crimson 4R and yellow-orange S).

Release form

Wobenzym is produced in the form of coated tablets of 40 or 200 pieces in packs and 800 pieces in high density polyethylene bottles.

pharmachologic effect

Immunomodulatory, fibrinolytic, antiplatelet, anti-inflammatory, decongestant.

Pharmacodynamics and pharmacokinetics

According to the Medical Wikipedia (MedViki), Wobenzym is a complex of highly active animals and vegetable (inzymes ). Data enzymes carefully selected, optimally combined and included in Wobenzym tablets, from which they have a fairly wide range of clinical applications.

Taking Wobenzym has a positive effect on the course inflammatory process , reduces pathological symptoms immunocomplex and reactions , has a positive effect on immunological reactivity the human body. Under the influence of active ingredients of drugs, the number of circulating drugs decreases immune complexes and the removal of their membrane deposits from tissues is carried out. The drug activates and corrects functionality natural killers ( ) and monocyte-macrophages , stimulates cellular activity, cytotoxic T lymphocytes and antineoplastic , for which the medicine Wobenzym is often prescribed as .

Treatment with Wobenzym reduces the infiltration of interstitial tissue plasma cells , increases the elimination of deposits fibrin and protein detritus from the inflamed area, forcing the lysis of metabolic and dying tissue structures, reduces swelling , accelerates resorption and also normalizes the permeability of the vascular walls.

The use of the drug leads to a decrease in the content thromboxane , decrease platelet aggregation , stabilization of adhesion of blood cells, increasing plasticity and their ability to change their own shape, normalizing the number and reducing the total number of their activated fractions, regulating blood viscosity and a decrease in the total amount microaggregants ... Thanks to these effects, rheological parameters of blood and her microcirculation , which determines the normal supply of tissues and organs of the human body with nutrients and oxygen.

Wobenzym lowers replication endogenous , normalizes exchange lipids , increases concentration HDL , reduces the content of atherogenic lipoproteins and improves absorption polyunsaturated fatty acids .

The appointment of Wobenzym enhances the effectiveness of the antibiotic therapy by increasing the level funds in the focus of inflammation and their plasma concentrations, starts the process of nonspecific defense of the body (production ), thereby exhibiting antimicrobial and antiviral effects, and also neutralizes symptoms. Also, the drug reduces the severity of side effects that occur when taking hormonal medicines (including hypercoagulation ).

When taken orally, due to resorption dimeric molecules , there is absorption of active ingredients of Wobenzym from the small intestine with the formation of protein complexes and further entry into the vascular bed. Circulating through the systemic circulation, enzymes fall into the zones of pathological processes, where they accumulate.

Indications for the use of Wobenzym

Annotation to Wobenzym positions it as a means for use in combination with other drugs used to treat certain pathologies, as an adjunct to the main treatment. Indications for the use of the drug cover many areas of medicine and recommend its appointment in the following cases.

In angiology:

• lymphatic;
• endarteritis ;
• post-thrombophlebitis disease;
• arterial obliterans of the legs ;
• recurrent phlebitis (prevention).

In gynecology:

• miscarriage (relative to the II and III trimester);
• salpingo-oophoritis;
• vulvovaginitis ;
• reduction in the severity and frequency of negative phenomena during hormone replacement therapy;

In gastroenterology:

• (dysbiosis);
• chronic inflammatory pathologies of the gastrointestinal tract;

In dermatology:

• (acne );
• itchy dermatoses.

In neurology:

• circulatory disorders of the brain of a chronic nature;

In cardiology:

• in the subacute stage;
• stresses .

In nephrology:

In otorhinolaryngology:

In ophthalmology:

• uveitis;
• hemophthalmos;
• ophthalmic surgery and prevention of postoperative complications.

In oncology:

• and (to improve portability);
• reducing the risk of secondary infections.

In pulmonology:

• pneumonia;

In dentistry:

• diseases of the oral cavity of an infectious and inflammatory nature.

In rheumatology:

• of various etiology.

In urology:

• cystopyelitis.

In traumatology:

• inflammatory processes of soft tissues;
• various ;
• post-traumatic manifestations chronic nature;
• sports injuries.

In pediatrics:

• pathology of the respiratory tract of infectious and inflammatory origin;
• postoperative complications ( , insufficient wound healing, local edema and suppuration ).

In surgery:

• lymphatic and post-traumatic edema ;
• postoperative complications ( , , inflammation ).

In endocrinology:

• and angiopathy (diabetic);
• autoimmune .

Additionally, indications for Wobenzym include the prevention of the following conditions:

• and adaptation;
• microcirculation disorders ;
• post-stress disorders;
• vascular accidents ;
• negative phenomena during ;
• viral infections or their subsequent complications;
• violations dysbiotic character at antibiotic therapy .

Contraindications

Before taking Wobenzym, you should familiarize yourself with the contraindications to its appointment, for which the following are conditions in which treatment with Wobenzym is absolutely prohibited:

• any pathologies occurring with an increased risk of possibility ;
• age up to 5 years;
• personal hypersensitivity to active and / or additional components of drugs;
• holding .

Side effects

Therapy with Wobenzym in most cases is tolerated without negative effects in the course of treatment and negative consequences after its completion. Also, until now, there has been no evidence of side effects of the drug, addictive to him or forming withdrawal syndrome , even in the case of prolonged therapy using high dosages.

In isolated cases, the occurrence of , as well as minor deviations in smell and stool consistency , which are leveled by a decrease in the dose of drugs or disappear after discontinuation of treatment.

Before prescribing Wobenzym, you need to warn the patient that in case of any adverse reactions associated with taking the drug, his duties include immediate discontinuation of therapy and further consultation with a doctor.

Wobenzym tablets, instructions for use

As a rule, the dosage regimen, like the duration of treatment, is determined on an individual basis, taking into account the disease itself, its severity, as well as all internal and external factors affecting the patient's condition.

For adult patients, the range of single doses of the drug, depending on the pathology, its severity and activity, is 3-10 tablets with a mandatory three times a day. Usually, during the first three days of therapy, they resort to taking 3 tablets three times every 24 hours. The further number of pills taken at one time may vary, while the frequency of their intake per day in all cases remains unchanged (3 times in 24 hours).

When moderate painful conditions appoint 5-7 tablets three times a day for 14 days. In the future, they switch to taking 3-5 tablets with the same frequency of administration. The general course of treatment is approximately 30 days.

When severe painful conditions appoint 7-10 tablets three times a day for 14-21 days. Subsequently, the dosage is reduced to 5 tablets with the same frequency of administration. The general course of therapy is 2-3 months.

When chronic pathologies Wobenzym tablets are recommended to be taken according to the indications and observed symptoms, in courses from 3 to 6 months.

To potentiate the effectiveness of the antibiotic therapy and preventing the formation dysbiosis recommend a three-time daily intake of 5 tablets throughout the course of use. In order to treat dysbiosis that has arisen after antibiotic therapy, appoint 3 tablets three times in 24 hours for 14 days.

Taking into account some similarity in the composition of drugs and the spread of their effects on the human body, two analogous drugs can be distinguished - Vobe-mugos E and .

The price of Wobenzym analogues (40 tablets) (using the example of these two drugs closest in effect) is slightly higher for Phlogenzyme - 950 rubles and much higher for Vobe-mugos E - 2900 rubles, for the same number of tablets.

For children

Wobenzym can be prescribed to children who have reached the age of 5 years. At the age of 5-12 years, the dosage of the drug is calculated per kilogram of weight (1 tablet per 6 kilograms).

With alcohol

It should be noted right away that with any pathology, taking any medications, and even against the background of complete health, alcohol, especially in large quantities, cannot benefit the human body. Considering the compatibility of treatment with Wobenzym with the intake of alcoholic beverages, one should also take into account the fact that this drug itself is prescribed quite rarely, but mostly it is part of the complex treatment of certain diseases, which indicates a variety of possible effects of complex therapy on the body as a whole. and on its individual organs and systems. For example, when combined with antibiotics , antiviral drugs , chemotherapy drinking alcohol is strictly prohibited, and with other combinations of drugs, its intake is undesirable and, at best, can lead to decrease in efficiency therapy, and at worst cause various severe complications ... Another area of \u200b\u200bapplication of the drug is treatment withdrawal symptoms and in this case, Wobenzym and alcohol are compatible as well as the very concepts of benefit and harm.

Wobenzym during pregnancy and lactation

The list of contraindications to the use of Wobenzym is absent as , so and. Moreover, during pregnancy, women are even recommended to take it for prevention of miscarriage, starting from the second trimester, where the action of the drug receives positive reviews. During pregnancy, the calculation of the dosage and the duration of taking the pills is determined individually, taking into account the general condition of the expectant mother, fetal health indicators and the course of the pregnancy itself.

Reviews about Wobenzym

Reviews about Wobenzym on the forums, however, like the reviews of doctors about Wobenzym, are quite contradictory and often lead to serious disputes among specialists and patients about the effectiveness, usefulness and safety of using this drug. The opinions of many doctors and people who have ever taken this drug on this score differ radically, and when some argue that for them complex treatment with the inclusion of Wobenzym was much more effective and safer than without it, others immediately find many arguments against and state about the complete uselessness of this drug.

For example, some nutritionists advise taking Wobenzym for weight loss in combination with and physical education and explain this by the ability of the drug to normalization of the function of the digestive tract and them microflora ... Some of the patients who have undergone such a course of diet therapy remain satisfied with its results and leave positive reviews about Wobenzym. The other part, who does not notice any special changes in body weight, naturally ascribes a negative result to Wobenzym.

Reviews of the drug in gynecology with ; at mastopathy , endometritis , vulvovaginitis , preeclampsia , cervicia ; diseases of sexual etiology ( chlamydia , mycoplasmosis , ureaplasmosis ), as well as reviews of Wobenzym at pregnancy mostly positive, but even here there are those who see in this only a coincidence of circumstances and the effect of other drugs taken in parallel.

In this situation, it is not possible to draw any definite conclusions, and therefore we can only advise you to rely on the opinion of your attending physician, especially if you trust him not only as a good specialist, but also as just a decent person.

Wobenzym price where to buy

The price of Wobenzym in Russian pharmacies, due to its considerable cost, does not differ much depending on the region, and therefore you can buy Wobenzym in Moscow for about the same as it costs in St. Petersburg, for example, in the Ozerki pharmacy.

The average price of 40 tablets is 450 rubles; 200 tablets - 1900 rubles; 800 tablets - 6500 rubles. The price of 100 Wobenzym tablets, when purchased "by weight" from a package of 800 pieces, is 900-1000 rubles.

Wobenzym can be bought in Kiev on average for: №40 - 200 hryvnia; No. 200 - 900 hryvnia; No. 800 - 3000 hryvnia.

• Online pharmacies in RussiaRussia
• Online pharmacies of UkraineUkraine
• Internet pharmacies in KazakhstanKazakhstan

ZdravCity

Wobenzym tab. bp n200Mukos Emulsions GmbH

Wobenzym tab. p.o n40Mukos Emulsions GmbH

Wobenzym tab. p / o ksh / sol. No. 100Mukos Emulsions GmbH

Wobenzym tab. bp n800Mukos Emulsions GmbH

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Wobenzym (tab. P / o No. 800)

Wobenzym (tab. P / o No. 200)

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Wobenzym n800 tablMukos Emulsions GmbH

Wobenzym n200 tabMukos Emulsions GmbH

Wobenzym No. 40 tablMukos Emulsions GmbH

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PaniApteka

Wobenzym tablets Wobenzym coated tablets No. 40

Wobenzym tablets Wobenzym coated tablets No. 800Germany, Mucos Emulsionsgesellschaft

Wobenzym tablets Wobenzym coated tablets No. 200Germany, Mucos Emulsionsgesellschaft

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Education: Graduated from Vinnitsa National Medical University named after NI Pirogov, pharmaceutical faculty, higher pharmaceutical education - specialty "Pharmacist".

Work experience: Work in the pharmacy chains "Konex" and "Bios-Media", specializing in "Pharmacist". Work in the specialty "Pharmacist" in the pharmacy chain "Avicenna" in the city of Vinnitsa.

Note!

Information about medicines on the site is a general reference, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medicines in the course of treatment. Before using the drug Wobenzym, be sure to consult with your doctor.

Reviews

I very badly tolerate antibiotics, usually stomatitis on the mucous membranes is added. That is, you are sick and you can't even take anything into your mouth, it's all sores and it hurts. The doctor prescribed wobenzym for better antibiotic absorption. Indeed, there was no stomatitis, she tolerated the medicine well and recovered pretty quickly. Now I will know if I have to take antibiotics again.

My husband suffered for a long time with chronic prostatitis, different doctors gave different treatments. But only with the introduction of wobenzym into the treatment was it possible to cure this chronic. The course is expensive and long, but the health of a man and well-being in the family is worth the money.

For a long time she was treated for endometriosis, doctors prescribed one treatment, then another. The effect appeared when a course of wobenzym was prescribed. The doctor said that he kind of stimulates the treatment, helps and accelerates it. The drug is natural, so there was no addiction, although it took a long time.

Before (and after) a small gynecological operation, she started taking Wobenzym to prevent the appearance of adhesions. And after that I also drank, as it helps the body recover faster. The gynecologist was pleased with the result.

Wobenzym was prescribed to me after the gynecological operation, so that the tissues were restored better, and adhesions did not form, there the enzymatic composition was very well selected. The drug helped - everything healed quickly, and without consequences

Took it 2 times, very happy. For the first time they were discharged after the operation so that adhesions would not form, the second - he cured thrush, the doctor recommended wobenzym to enhance the action of antifungal drugs and raise immunity so that it does not recur.

2 years could not conceive a baby. We already thought about going to IVF. And then I went to another gynecologist and it turned out that I just had adhesions in the tubes after the inflammation. The doctor immediately prescribed Wobenzym for resorption of pathological tissues and prescribed a course of electrophoresis with enzymes. And already 3 months after the treatment, I became pregnant!

Wobenzym was taken two months after giving birth to accelerate the body's recovery process. I really recovered quickly, after a month at the examination they said that all the seams from the ruptures were almost completely healed. Maybe, of course, this is just my natural feature that tissues are so quickly restored and wounds are healed (although I did not notice this before), but I can say for sure that wobenzym strengthened my immunity. I gave birth in October, now it is June, and during all this time I have never had a cold, even a slight runny nose, can you imagine ?! Although before the snot flowed as soon as the breeze blows. So as an immunostimulant it definitely works.

This drug was prescribed by a gynecologist after laparoscopy. She explained to me that wobenzym is a good remedy for inflammatory processes and will raise immunity at the same time. I drank it for one month. To my happiness, no new adhesions were formed. And the blood test showed good results - the inflammation passed quickly.

Wobenzym is a universal drug. I drink it when I am sick with viral diseases - to raise immunity. I also parted with the thrush thanks to him. For several years now, there has been no thrush, and before that she constantly crawled out and gave me a lot of unpleasant sensations and discomfort. I think women who have come across this will understand me. In general, I advise all the fair sex.

Wobenzym is a find drug for me. Its enzymes improve the functioning of the whole body. I periodically drink a course of wobenzym and feel great. The first time it was prescribed to me by a gynecologist for inflammation of the appendages. When I began to drink it, the pain in the lower abdomen immediately disappeared, apparently it also has an analgesic effect.

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The drug Wobenzym is a specially created complex of biologically active enzymes of animal and plant origin. This complex of enzymes has strong immunomodulatory, anti-inflammatory, anti-edematous and secondary analgesic properties. The enzymes included in the complex are necessary for the normal functioning of the body and are involved in almost all biological processes in the body. If their number decreases, then this often leads to the occurrence of various diseases. Wobenism has a positive effect on the inflammatory process, limits the manifestation of autoimmune processes, and is also able to influence the indicators of the body's immunological reactivity.

Wobenzym, composition and form of release

Wobenzym is an enteric-coated tablet with an orange smooth surface and a specific odor. The tablet contains the following components:

Pancreatin (100 mg);
- bromelain (45mg.);
- papain (60 mg.);
- trypsin (24 mg.);
- amylase (10 mg.);
- chymotrypsin (1 mg.);
- rutin (50mg.);
- lipase (10 mg.)

In addition to the above components, the composition contains other auxiliary substances: corn starch, lactose, magnesium stearate, talc, lactose, sucrose, colloidal silicon dioxide.

The number of tablets in a blister is 20 pieces. Available in packs of 40, 200 or 800.

Wobenzym: properties

The drug Wobenzym, the instruction to which is attached, has the following positive properties for the body:

Antiplatelet and fibrinolytic action;
- prevents the manifestation of autoimmune pathologies;
- increases the functionality of macrophages;
- promotes the immunological activity of the body;
- stimulates the activity of T - lymphocytes, natural killer cells (NK - cells);
- stimulates phagocytic activity of cells, which affects antitumor immunity;
- reduces the number of circulating immune complexes;
- reduces the infiltration of the interstitium by plasma cells;
- accelerates the breakdown of toxins;
- accelerates the process of resorption of hematomas and edema;
- increases the permeability of the walls of blood vessels, which leads to an increase in the rate of elimination of toxins from the body;
- regulates the adhesion of blood cells;
- normalizes density, viscosity and blood microcirculation;
- normalizes lipid metabolism;
- increases the amount of high density lipoproteins;
- reduces the synthesis of endogenous cholesterol;
- increases the concentration of antibiotics in the focus of infection processes;
- has the ability to reduce the negative effects caused by hormonal therapy and antibiotic therapy;
- regulates the production of interferons;
- exhibits antiviral and antimicrobial action;
- improves the absorption of polyunsaturated fatty acids.

Wobenzym: indications and applications

As part of complex therapy or monotherapy, it is actively used for the following diseases:

Postphlebitic syndrome, thrombophlebitis (including acute thrombophlebitis of superficial veins), lymphatic edema, obliterating endarteritis and atherosclerosis of the arteries of the lower extremities, prevention of recurrent phlebitis;
-prostatitis, cystitis, cystopyelitis;
- sexually transmitted infections;
-chronic infections of mastopathy, genitals, gestosis, adnexitis, to reduce the frequency and severity of side effects of hormone replacement therapy in gynecology;
- angina pectoris, subacute stage of myocardial infarction (to improve the rheological properties of blood);
-sinusitis, bronchitis, pneumonia;
-pancreatitis, hepatitis;
- pyelonephritis, glomerulonephritis;
-diabetic angiopathy, diabetic retinopathy;
-Autoimmune thyroiditis;
-rheumatoid arthritis, reactive arthritis, ankylosing spondylitis;
atopic dermatitis, acne;
-multiple sclerosis ;
- veitis, iridocyclitis, hemophthalmos, application in ophthalmosurgery;
-treatment of postoperative complications (inflammation, thrombosis, edema), adhesive disease, post-traumatic and lymphatic edema, plastic and reconstructive surgery;
-injuries, fractures, distortions, injuries of the ligamentous apparatus, bruises, chronic post-traumatic processes, inflammation of soft tissues, burns, injuries in sports medicine.

Wobenzym: contraindications
- hemodialysis;
- age up to 5 years;
- poor blood coagulation;
- hypersensitivity to components.

Wobenzym, instructions for use:

Wobenzym is used in doses from 3 to 10 tablets 3 times a day. The first days the drug is recommended to take 3 tablets 3 times a day, and further dosage depends on the severity of the disease and the individuality of the organism.

The average activity of the course of pathologies involves taking Wobenzym in an amount of 7-10 pieces 3 times a day for 2-3 weeks. Further, as a preventive measure, take 5 tablets 3 times a day for 2 to 3 months.

Long-term diseases that are chronic in nature require taking the drug for 3-6 months.
With a combination of Wobenzym and antibiotics, the drug is taken during the entire time of taking antibiotics, 5 tablets per day. Further, in order to restore the microflora of the stomach, Wobenzym should be taken 2-3 tablets 3 times a day for a course of 2 weeks.

During the period of application of chemotherapy or radiation therapy, Wobenzym is recommended to use the drug 3 times a day, 3-5 tablets, throughout the entire course of oncology treatment.

For preventive purposes, the Wobenzym preparation instruction recommends taking 2-3 tablets three times a day for a month and a half. The course must be repeated twice or thrice a year.

For children who have reached 12 years of age, taking the drug is recommended in the same doses as for adults: 3-5 tablets 3 times a day.

The instruction requires you to follow the rules of admission: take 30 minutes before meals and, without chewing, drink a glass of water.

Wobenzym: side effects

The drug Wobenzim, reviews, the use of which testify to its good tolerance, although in some cases, side effects can still be observed. When diarrhea, nausea, vomiting, urticaria appear, the dose of the drug should be reduced.

With extreme caution, it is worth taking the drug for pregnant women, as well as with the complex use of the drug with drugs that reduce blood clotting.

Wobenzym: price and sale

The drug is widespread and very popular. You can buy wobenzym at any pharmacy, but this drug differs in that there are frequent cases of detection of counterfeit and fakes of the drug. The drug Wobenzym, the price of which is almost the same everywhere, is better not to buy from hands. It is worth making sure that there is a certificate of conformity for the goods, which can be provided at specialized points of sale of medical products.

The presence of side effects from taking the drug Wobenzym, reviews of which, in principle, are quite positive, require a doctor's consultation and familiarization with the manufacturer's annotation. Since this instruction is provided in a free translation.

Wobenzym, the price of which is about 1,500 rubles for a package of 200 tablets, has its own constant circle of consumers.

Wobenzym and Transfer Factor

Wobenzym must be taken for about 3 weeks in order to undergo a course of therapy. Thus, the cost of treatment with this drug will be about 3,500 - 5,000 rubles, and the treatment may need to be repeated several times in order to achieve a result. The drug Transfer Factor also performs the same functions as Wobenzym, which costs about 2,000 rubles for a pack of 90 capsules.

The transfer factor has no contraindications, but on the contrary is indicated for admission to people of any age category, patients with various diseases and just people who want to take care of their health in advance. Transfer factor treatment is not accompanied by any side effects, is not addictive, overdose with this drug is also impossible.

In addition, Transfer Factor has a more dramatic effect on the human body and not only helps to cope with the disease, as other medications do, but also repairs damage to human DNA and restores the immune system. After all, it is precisely the malfunctions in the functioning of the immune system that are the main reasons that various diseases arise in the body. Even if the decision is made to take Wobenzym, it is better to do this in combination with the Transfer factor, which is able to neutralize its negative effects on the body.

Systemic enzyme therapy is a method of treatment using purposefully formulated mixtures of highly active plant and animal enzymes that affect inflammation, immune responses, and reparative processes. One of such complex enzyme preparations is “ Wobenzym» ( Wobenzym) - a set of enzymes of animal and plant origin with the addition of rutoside. Used "Wobenzym" in the complex therapy of many diseases, heals the body.
In a number of countries, "Wobenzym" is registered as a food biologically active additive (BAA) and its distribution as a medicine is prohibited (for example, in the USA). Wobenzym was registered as a medicine in Russia in 2010. Manufacturer - "Mukos Emulsions GmbH", Germany.

Indications for the use of "Wobenzym"

The main indications for the use of "Wobenzym" are post-traumatic edema, inflammatory processes in surgical pathology and in the postoperative period, lymphedema of various etiologies, post-thrombophlebitic syndrome, superficial thrombophlebitis, some autoimmune and immunocomplex diseases (rheumatoid arthritis, multiple sculonephritis) recurrent inflammatory processes of the upper and lower respiratory tract, ear, genitourinary system, digestive tract, joints, etc.
It should be remembered that in case of infectious and inflammatory processes, "Wobenzym" does not replace antibacterial agents, but increases their effectiveness.

Method of application of "Wobenzym" and doses

The dose of the drug "Wobenzym" is selected individually, taking into account the nature and severity of the disease. First, appoint 5-10 tablets 3 times a day, the maintenance dose is usually 3 tablets 3 times a day. The tablets are recommended to be taken 30 minutes before meals, without biting, and washed down with plenty of liquid (at least 250 ml).

For thrombophlebitis and post-thrombophlebitic syndrome, "Wobenzym" is prescribed, depending on the severity of the disease, 5-10 tablets per dose 3 times a day for 7-14 days until the elimination of edema and inflammation, then the dose is reduced to 3-5 tablets per dose. Usually, the effect occurs on the 4th day. To achieve good results, it is recommended to carry out the treatment for 1–2 months. With obliterating endarteritis of the vessels of the lower extremities, the therapeutic dose and the duration of the course of treatment are selected individually, but not less than 15 tablets per day. For the treatment of II-III degree lymphatic edema after mastectomy, Wobenzym is prescribed 7 tablets 3 times a day simultaneously with tocopherol (100 mg 3 times a day) for 4 weeks, then the drug is used in a maintenance dose.

With rheumatoid arthritis and ankylosing spondylitis, Wobenzym is prescribed 8-10 tablets 3 times a day, after reaching remission, they switch to a maintenance dose - 5 tablets 3 times a day for a year or more. If necessary, for the speedy elimination of pain syndrome, the drug is taken simultaneously with indomethacin or other non-steroidal anti-inflammatory drugs. For patients with reactive arthritis, Wobenzym is prescribed 5 tablets 3 times a day for 3-4 weeks in combination with antibacterial and non-steroidal anti-inflammatory drugs.

In gynecology and obstetrics, "Wobenzym" is usually prescribed 5 tablets 3 times a day for 16-17 days, for inflammatory processes "Wobenzym" is taken simultaneously with antibiotics.

For the treatment of venous diseases (thrombophlebitis, post-thrombophlebitic syndrome), it is recommended to prescribe 10 tablets of "Wobenzym" 3 times a day for 2 weeks.

In traumatology for volumetric surgical interventions (endoprosthetics, complex reconstructive operations, transplantation and replantation), "Wobenzym" is prescribed according to a special scheme: 1st week - 10 tablets 3 times a day, 2nd week - 7 tablets 3 times a day , then 5 tablets 3 times a day for 1-1.5 months. With conservative and surgical treatment of patients with minor injuries of soft tissues and muscles, as well as isolated fractures of individual segments, the duration of therapy may be limited to 2-3 weeks.

In sports medicine, "Wobenzym" is prescribed for prophylactic purposes during sports competitions (5 tablets 3 times a day), as well as for injuries (10 tablets 3 times a day).

Contraindications to the use of "Wobenzym"

Contraindications to the use of the method of systemic enzyme therapy are severe disorders of the blood coagulation system (with hemophilia or severe liver failure). When prescribing the enzyme preparation "Wobenzym" to patients in the pre- and postoperative period, its fibrinolytic effect should be taken into account. Wobenzym is prescribed with caution during pregnancy.
Side effects even with prolonged treatment with "Wobenzym" are rarely observed, mainly a change in the color, consistency and odor of feces. Allergic reactions rarely occur, which disappear after drug withdrawal.

Pharmacokinetics of the drug "Wobenzym"

The pharmacokinetics of the polyenzyme preparation " Wobenzym", Which includes papain (plant enzyme papaya). After ingestion, enzymes are absorbed in the small intestine in an active form, while maintaining hydrolytic activity. The absorption of some enzymes in the small intestine reaches 20%. In the blood, enzyme macromolecules bind to the antiproteases α1-antitrypsin and α2-macroglobulin. Due to this, antigenic determinants of proteases are screened, which do not cause sensitization of the body. The maximum concentration of the components of polyenzyme preparations is reached after 2 hours, is maintained at a stable level for 4 hours, and then decreases within 2 hours. The half-life is 8 hours. The enzymes circulating in the blood are partially captured by the stellate reticuloendothelial cells of the liver and other cells of the mononuclear phagocyte system. About 10% of Wobenzym is excreted in the urine, about 45% in the feces. The drug, which is not absorbed in the intestines, is involved in digestion processes.

Clinical trials of the drug "Wobenzym"

Numerous clinical trials have shown that complex enzyme preparations correspond to general therapeutic principles - they are characterized by reliability and high efficiency with good tolerance, which determines a wide range of clinical applications. The method of systemic enzyme therapy has been introduced in various fields of clinical medicine (most often the complex enzyme preparation "Wobenzym" is prescribed for this purpose).

In pulmonology "Wobenzym" is used in combination with antibiotics and other drugs for the treatment of inflammatory diseases of the respiratory system: acute and chronic bronchitis, pneumonia, bronchiectasis. It was found that the use of enzymes in complex therapy promotes an increase in the concentration of antibiotics in the pathological focus, reduces the viscosity of secretions, improves bronchial clearance and regeneration of the respiratory epithelium. The dissolution of microthrombi in the pathologically altered parenchyma improves microcirculation and contributes to the saturation of tissues with antibacterial drugs, cleans the alveoli from fresh fibrin clots, and activates lymph absorption. Enzyme preparations (including "Wobenzym") are prescribed until recovery or a stable remission of the disease. They are an effective means of preventing congestive bronchitis and pneumonia in elderly patients who are on bed rest.
The timely appointment of enzyme therapy has a beneficial effect on the course of pulmonary infarction or infarction pneumonia.
The use of "Wobenzym" for sinusitis, laryngitis helps to cleanse the mucous membrane and eliminate the focus of inflammation.
The positive effect of systemic enzyme therapy in hepatitis, ulcerative colitis, Crohn's disease, chronic pancreatitis has been noted.

In rheumatology the enzyme preparation "Wobenzym" is used in the complex treatment of rheumatoid arthritis, deforming osteoarthritis, ankylosing spondyloarthritis (ankylosing spondylitis), juvenile rheumatoid arthritis, systemic vasculitis, there is evidence of a good clinical effect in systemic lupus erythematosus.
In case of rheumatoid arthritis, "Wobenzym" with prolonged (for 12 months) continuous use has shown the same efficacy as oral preparations of gold, which suggests a possible basic effect of the drug. Against the background of treatment with enzyme preparations, there is a rapid decrease in clinical and laboratory signs of the activity of immune inflammation, restoration of joint mobility, reduction of morning stiffness and soreness.

In ankylosing spondylitis, the effectiveness of enzyme preparations for a number of parameters is higher than indomethacin. Enzyme therapy is used to treat reactive arthritis (especially with resistant and recurrent forms), tendovaginitis, bursitis, periarthritis, myositis. In osteoarthritis, especially complicated by secondary synovitis, the therapeutic efficacy of Wobenzym is comparable to that of diclofenac. In the course of monotherapy and complex treatment with "Wobenzym" rheumatic diseases, pronounced adverse reactions were not observed. In this regard, the drug can be used continuously for 12 months or more without special laboratory control. Appointment of "Wobenzym" to patients with rheumatoid arthritis improves tolerance and reduces the dose of cytostatics, non-steroidal anti-inflammatory drugs and glucocorticoids by 30-50%, which is a significant success in the prevention of side effects of these drugs.

The use of "Wobenzym" in the complex treatment of chronic patients reduces the time for elimination of clinical symptoms and laboratory indicators of the activity of the inflammatory process in the kidneys, due to the normalization of immune reactivity indicators, rheological properties of blood and restoration of balance between the state of lipid peroxidation and the body's antioxidant defense system. The effectiveness of systemic enzyme therapy in the complex treatment of glomerulonephritis has been established. In kidney disease, the fibrinolytic (thrombolytic) effect of combined enzyme preparations promotes the disappearance of the casts and restores the patency of the renal tubules.

In urological practice systemic enzyme therapy gives good clinical results in prostatitis, cystitis, orchitis and epididymitis. It accelerates the process of transurethral drainage of the prostate in chronic obstructive lesions. Systemic enzyme therapy promotes the lysis of the plugs of the excretory ducts, a decrease in the viscosity of the secretion and the number of leukocytes in the aspirate obtained during transurethral drainage. The patients showed an important positive clinical dynamics: pain and dysuria disappeared, sexual function was restored ( Guskov A.R. et al., 1998).

Appointment of "Wobenzym" in a dose of 5-7 tablets 3 times a day for 3-4 weeks together with two intermittent 10-day courses of antibiotics (tarivid or vibramycin) allows achieving clinical recovery with complete elimination of the pathogen in urogenital chlamydia and ureaplasmosis at 87, 5% and 96% of cases, respectively. With mycoplasmosis, clinical recovery was observed in 100% of patients.

In gynecology and obstetrics systemic enzyme therapy is used in the complex treatment of mastopathy, adnexitis, habitual miscarriage, oncological diseases, as well as venous pathology and pyelonephritis in pregnant women. It is advisable to include "Wobenzym" in the scheme of complex treatment of vaginitis, cervicitis, acute and chronic endometritis, salpingo-oophoritis, parametritis, pelvic peritoneal joints, tubal infertility, cervical dysplasia. Systemic enzyme therapy is the most effective conservative method of treating fibrocytic mastopathy; it is indicated for the treatment of mild and moderate forms of pre-eclampsia in pregnant women. "Wobenzym" is also prescribed for late toxicosis of pregnant women.

The appointment of "Wobenzym" in the postoperative period for infective endocarditis (in two courses: the first - 2 weeks, 8 tablets per day, the second - for a month during the rehabilitation period, 6 tablets per day) contributes to the stable correction of disturbed immunological parameters. The normalization of most of the immunological parameters occurred on the 45th day (after the second course of systemic enzyme therapy) and persisted for 6 months ( Vorobieva A.M. et al., 1998).

The use of "Wobenzym" within a month after myocardial infarction in a daily dose of 9 tablets contributes to the normalization of the plasma lipid profile (reliably reduces the level of cholesterol and cholesterol-containing low-density lipoproteins (by 24 and 31%, respectively), lipid peroxidation processes (reduces the level of malonic dialdehyde), normalizes the number of circulating immunocompetent cells.Under the influence of "Wobenzym" in most patients, the level of circulating immune complexes and titers of antibodies to the affected myocardium significantly decreased.

In angiology systemic enzyme therapy is widely used to treat diseases of peripheral arteries and veins, including varicose veins of the superficial and deep veins of the lower extremities, thrombophlebitis (efficiency is more than 90%), post-thrombophlebitic syndrome, phlebothrombosis. Due to the improvement of capillary permeability and a decrease in blood viscosity in patients with venopathies, hyperemia and edema in the affected area, recurrence of thrombosis, muscle cramps, decrease the feeling of fatigue and the severity of pain. During the treatment with "Wobenzym" there was no progression of blood reflux through the veins of the affected limbs. In 28.3% of patients, when using systemic enzyme therapy, complete recovery occurred. "Wobenzym" helps prevent blood clots... For venous pathology, local application of enzymes in the form of ointments is effective.

Numerous studies have shown that under the influence of systemic enzyme therapy "Wobenzym" observed, inhibition of sclerosis (atherogenesis) processes in the vascular wall, improvement of endothelial function by reducing the degree of adhesion of blood cells and cytokine damage, splitting of deposits of immune complexes, which is important in patients with autoimmune damage to the vascular wall, for example, with systemic vasculitis, etc.).
In diabetic angiopathies complicated by the syndrome of disseminated intravascular coagulation, the use of Wobenzym, in addition to reducing pain and swelling of the extremities, accelerates the healing of trophic ulcers and reduces the percentage of patients who required amputations, significantly improves coagulogram indices, and normalizes the fibrinogen content in the blood.
Elimination of the syndrome of disseminated intravascular coagulation by "Wobenzym" in patients with purulent-necrotic complications of diabetic angiopathies significantly improves wound healing. Improving impaired microcirculation, "Wobenzym" significantly reduces the risk of thromboembolic complications.

Enzyme preparations are prescribed for the prevention and treatment of secondary lymphatic edema developing against the background of erysipelas, after oncological operations. Patients who are constantly taking “ Wobenzym»For 2 years, after surgical treatment of breast cancer, lymphatic edema was 5 times less common.

The positive clinical experience of using "Wobenzym" in hemorrhagic vasculitis (Shenlein-Henoch disease), autoimmune thrombocytopenia, Wegener's disease and Behcet's syndrome was noted.

Enzyme therapy is gaining popularity in dentistry. It is indicated for all inflammatory processes in the oral cavity, as well as after tooth extraction and root surgery.
Systemic enzyme therapy is used for prophylactic and therapeutic purposes in plastic surgery - it promotes the healing of cosmetic sutures, the formation of invisible delicate scars.

There were noted good, although not always stable, results of treatment with "Wobenzym" for sciatica.

Systemic enzyme therapy helps to withstand training loads of increased volume and intensity, contributes to the achievement of a stable sports form. Reception of "Wobenzym" does not cause disruption of adaptive mechanisms and depletion of the immune system during intense training; the level of athletic capacity for work is significantly increased according to the control biochemical and psycho-functional tests. The effect after a month's course of systemic enzyme therapy lasts for 10-14 days. Reception of "Wobenzym" by athletes before the competition reduces the possibility of traumatic injuries of ligaments and muscles, promotes their rapid healing. According to numerous studies, the appointment of "Wobenzym" 10 tablets 3 times a day from 10-14 days to 4-6 weeks allows you to start sports training after injuries, on average, 2–2.5 times faster than in patients who received traditional therapy.

There is a wealth of experience in the use of enzyme preparations in oncology... Enzyme therapy for oncological diseases can be effective if you start treatment in the early stages of the disease, use the drug in large doses and continue treatment even after a visible remission is achieved. Unlike cytostatics, enzyme therapy does not give side reactions, there is no danger of overdose. The drug "Vobe-Mugos" is widely used in oncology.
The drugs "Vobezim" and "Vobe-Mugos" were used to treat lymphogranulomatosis and non-Hodgkin's lymphomas. In combination with irradiation, enzyme preparations (2 tablets 4 times a day) made it possible to achieve a significant resorption of a large mass of tumors, a pronounced normalization of hematological parameters, and reduce the time of subsequent irradiation.

In case of experimental alimentary hypercholesterolemia of rabbits, it was confirmed that the drug "Wobenzym" exhibits a pronounced and antiatherogenic effect. Along with a decrease in serum cholesterol levels, it inhibits by 2.8–3.2 times the rate of uptake of plasma lipoproteins by a culture of mouse macrophages.

Based on articles by B. M. Zuzuk, R. V. Kutsik, L. M. Kurovets, G. T. Nedostup,
Ivano-Frankivsk State Medical Academy

All pathological processes occurring in the body are in one way or another associated with damage to cells and tissues. In this state, the biological system is in dire need of compensation for the defect. For this purpose, the German pharmaceutical company MUKOS Emulsions GmbH has developed Wobenzym, detailed instructions for the use of the drug can be found in this article.

Pharmacological properties

First of all, we will tell you what kind of drug it is and from what it helps? Wobenzym is included in the group of systemic enzyme preparations. The basis of the pharmacological product is made up of enzymes of animal and plant origin. All components are produced only from natural raw materials. The quality of the drug determines its important role in various biochemical processes in the body.

The active ingredients of the drug help to improve lipid metabolism, saturate tissues with oxygen and essential nutrients, and accelerate regenerative processes. The tool normalizes blood flow, regulates platelet formation, and limits the production of cholesterol.

Wobenzym stops damaged cells, toxins, and removes them from the body. Stimulates the immune system, significantly reducing the risk of relapses and complications. Improves the functioning of the digestive tract and the quality characteristics of blood. It activates the body's reserve stock to combat acute inflammatory processes and neoplastic neoplasms. The product enhances the effect of antibacterial drugs, reduces the negative effect of hormonal substances.

The opinion that Wobenzym is not a medicine, but a dietary supplement is wrong. Despite the similarity of the chemical composition of the drug with the compositions of biologically active additives, the official instruction confirms that the product belongs to the pharmacotherapeutic group.

Dosage form and active ingredients

Wobenzym is available in tablet form. The product has a pronounced specific smell, a protective surface in the form of an enteric shell of red-orange color. The dosage form of the drug is packaged in blisters of 20 pcs. The carton contains from 2 to 10 blister cases. The second variant of packing of Wobenzym tablets is plastic bottles of 800 pcs.

For each tablet you have:

• pancreatin - 100 mg;
• papain - 60 mg;
• routine - 50 mg;
• bromelain - 45 mg;
• trypsin - 24 mg;
• amylase - 10 mg;
• lipase - 10 mg;
• chymotrypsin - 1 mg.

The drug is endowed with high bioavailability. The maximum concentration is reached after 2 hours from the moment of consumption, it lasts for 4 hours.

When is Wobenzym prescribed

The pharmacological product is widely used in various medical practices.

Indications for appointment:

• thrombophlebitis; endarteritis, obliterating atherosclerosis, recurrent phlebitis, lymphatic edema;
• cystitis, urinary tract infections, cystopyelitis, prostatitis, venereal diseases;
• mastopathy, adnexitis, gestosis, elimination of pronounced side effects of hormone-based drugs;
• myocardial infarction, exertional angina;
• pneumonia, sinusitis, tuberculosis, bronchitis, bronchial asthma;
• ulcerative colitis, inflammatory liver disease, pancreatitis;
• chronic diseases of the urinary tract and kidneys;
• complications associated with surgical interventions - adhesions, thrombosis, edema;
• traumatic injury and inflammation of soft tissues, fractures, colloidal scars, sprains, sports injuries, post-traumatic complications, burns;
• rheumatoid arthritis, ankylosing spondylitis;
• inflammatory diseases of the skin, acne, dermatosis;
• neurological pathologies with lesions in the brain or spinal cord;
• inflammatory diseases of the choroid, iridocyclitis, hemophthalmus, diabetic retinopathy.

Wobenzym is used to strengthen immunity and improve the quality of life in the treatment of cancer with the help of chemicals and radiation therapy.

Dosing rules

Let's figure out how to take Wobenzym.

The drug is taken half an hour before a meal with a sufficient amount of liquid.

The dosage depends on the severity of the pathologies and their activity. For adults, the dose ranges from 9 to 30 tablets per day. At the initial stage of treatment (the first 3 days), it is recommended to take 3 tablets three times.

For diseases of moderate severity, the drug is used 3 times in the amount of 5 - 7 pcs. for 14 days. In the next 14 days, the dosage is reduced to 3 - 5 pcs. 3 times a day.

For the treatment of acute diseases, the dosage is 7-10 pcs. 3 times a day for 2 - 3 weeks. Then the drug is used for another 2 - 3 months, 3 times up to 5 pcs.

Pathologies in a chronic form involve taking Wobenzym from 3 months to six months.

When treating with antibacterial drugs, to enhance the effectiveness and prevent the development of dysbiosis, the product is used throughout the entire therapeutic course, 5 pcs. 3 times. The intestinal microflora is restored with a two-week course of Wobenzym 3 times a day, 3 pcs.

The dosage for children aged 5 - 12 years is calculated according to the principle - 1 pc. per 6 kg of body weight. Upon reaching the age of 12, the treatment regimen developed for adults is applied.

At the initial stage of the treatment course, symptomatic manifestations of the disease may worsen. In this case, it is recommended to reduce the dosage of the drug.

Attention!

The treatment regimen (how much and how to take) is selected by the attending physician individually. The gestation period and breastfeeding are not considered as contraindications. But the treatment is carried out only under the supervision of a specialist.

Contraindications

Wobenzym has a minimum number of contraindications:

• pathologies with an increased risk of bleeding;
• period of hemodialysis;
• allergic reactions to the components of the drug;
• age up to 5 years.

Clinical studies have confirmed that the drug is well tolerated by patients. In the overwhelming majority of cases, long-term treatment with high dosages did not lead to side effects, withdrawal symptoms, or addiction. In isolated cases, slight changes in the density and smell of fecal excrement, skin rashes, itching were observed. The manifestations were quickly eliminated after dose reduction or withdrawal of the pharmacological product.

If taking a drug provoked adverse reactions that are not listed in the official annotation, you should stop taking the drug and immediately seek medical help.

Wobenzym or Phlogenzym: comparative characteristics

Consumers often wonder which is better than Phlogenzym or Wobenzym, given that both drugs are produced by the same manufacturer and belong to the group of systemic enzyme agents. Comparative characteristics of pharmacological products will help to understand this.

First of all, Phlogenzyme has a different complex of hydrolytic enzymes:

• routine - 100 mg;
• bromelain - 450 U;
• trypsin - 1440 U .;
• additional ingredients including lactose monohydrate.

Unlike Wobenzym, Phlogenzyme contains no components such as pancreatin, papain, lipase, amylase, chymotrypsin. This narrows the range of indications for the drug. But an increased dosage of bromelan and trypsin allows for the most pronounced activity in the treatment of acute inflammatory diseases.

Indications for prescribing Flobenzym:

• injuries accompanied by inflammation and tissue edema;
• recovery in the postoperative period;
• prevention of adhesive disease and colloidal scars;
• acute inflammatory infections of the genitourinary and respiratory system;
• deep vein thrombosis, thrombophlebitis;
• reduction of side effects with hormone therapy;
• infectious diseases of the oral cavity;
• soft tissue rheumatism and rheumatic pathologies;
• rehabilitation period after ischemic stroke;
• diseases of the liver, gallbladder and bile ducts.

The manufacturer in both cases regulates identical contraindications for use. There are more side effects when taking Phlogenzym. Doctors should approach the appointment of this drug with extreme caution. During treatment, it is mandatory to monitor the level of enzymes in the blood.

Price plays an important role. By positioning Phlogenzyme as a new generation drug, the manufacturer has significantly increased the cost.

For the sake of fairness, we note that both drugs have universal properties, and each individually is unique in its own way.

Wobenzym's analogs

Wobenzym has no structural analogs in terms of active components. At the moment, there are drugs on the pharmaceutical market that have a similar pharmacological effect.

These include:

• Imupret;
• Tonsilgon;
• Immunal;
• Anaferon;
• Aflubin.

Russian counterparts: Amiksin, Imudon, Glutoxim, Longidaza, Cytochrome - C, Esculus, Evenzyme.

Do not make a choice in favor of a drug without first consulting your doctor.

Enzymes (enzymes) are involved in almost all vital processes of the body. Reduced enzyme activity often leads to the development of chronic diseases. Wobenzym is a combination of highly active plant and animal enzymes with anti-inflammatory, anti-edema, fibrinolytic, immunomodulatory and secondary analgesic effects. The drug reduces the activity of the inflammatory process, reduces the severity of pathological manifestations of autoimmune and immunocomplex processes, accelerates the elimination of toxic metabolic products and lysis of necrotic tissues, accelerates the resorption of hematomas and edema, and normalizes the permeability of the vascular wall. Wobenzym improves microcirculation and rheological properties of blood, blood supply and tissue oxygenation.
Wobenzym has a hypolipidemic, immunocorrective and antioxidant effect, influencing the risk factors for the development of reinfarction.
After oral administration, from 4 to 20% of the active components of the drug are absorbed in the small intestine, the rest takes part in the digestion process and is excreted in the feces. Enzymes that enter the systemic circulation bind to antiproteases (the active form of α2-macroglobulin), maintaining their activity. The maximum concentration in the blood is reached 2 hours after oral administration and lasts for 4 hours. The half-life is about 8 hours.

Indications for the use of the drug Wobenzym

Sinusitis, bronchitis, pneumonia, pancreatitis, ulcerative colitis, Crohn's disease, multiple sclerosis.
Cardiology: Ischemic heart disease, secondary prevention of myocardial infarction.
Rheumatology: rheumatoid arthritis, osteoarthritis, rheumatism, ankylosing spondylitis, Sjogren's disease.
Surgery: inflammatory processes, post-traumatic edema, including postoperative ones, in particular after plastic and reconstructive operations.
Angiology: thrombophlebitis, post-thrombotic syndrome, vasculitis, thromboangiitis obliterans, lymphatic edema, prevention of recurrent phlebitis.
Urology: cystitis, pyelitis, prostatitis.
Gynecology: chronic infections, adnexitis, mastopathy.
Traumatology: fractures, bruises, inflammatory processes of soft tissues, distortions, dislocations, chronic post-traumatic processes, injuries in sports medicine.

Application of the drug Wobenzym

The dose of the drug is set individually, taking into account the nature and severity of the disease. At the beginning of treatment, 5-10 tablets are prescribed 3 times a day, depending on the degree of disease activity. Treatment is continued until recovery or clear clinical remission is achieved. The maintenance dose is usually 3 tablets 3 times a day.
Dragee is recommended to be taken 30 minutes before meals without chewing, drinking plenty of liquid (at least 200 ml).

Contraindications to the use of the drug Wobenzym

Hypersensitivity to drug components; diseases in which there is a high risk of developing hemorrhagic complications.

Side effects of the drug Wobenzym

In some cases, minor changes in the consistency and odor of feces, an allergic reaction like urticaria, which passes after the drug is discontinued, are possible.

Special instructions for the use of the drug Wobenzym

In case of infectious and inflammatory processes, Wobenzym does not replace antibacterial agents, but increases their effectiveness.
In diseases and invasive interventions accompanied by an increased likelihood of bleeding, or in cases where increased lysis of fibrin is undesirable, the fibrinolytic effect of Wobenzym must be taken into account.
Care should be taken when prescribing the drug during pregnancy.

Interactions of the drug Wobenzym

There were no cases of incompatibility while taking Wobenzym with other drugs. In the case of simultaneous use with antibiotics, Wobenzym increases the effectiveness of their action at the points of application.

Wobenzym overdose, symptoms and treatment

Diarrhea may develop, which disappears 1-3 days after drug withdrawal.

Storage conditions of the drug Wobenzym

Store in a dark place at room temperature.

List of pharmacies where you can buy Wobenzym:

• St. Petersburg