Lincomycin in dentistry: instructions for use. Lincomycin tablets - features of the antibiotic Lincomycin children dosage

Many dental diseases require therapy with antibacterial agents.

Depending on the characteristics of the inflammatory process, drugs of various groups are prescribed. Lincomycin is one of the commonly used drugs.

Thanks to broad spectrum of action with the help of Lincomycin, drug therapy is carried out for pathologies, the development of which was provoked by gram-positive flora.

By changing the dosage, it is possible to ensure the presence of the drug in the body in the concentration required to achieve a certain clinical effect.

pharmachologic effect

Lincomycin, which is a member of the lincosamide group, has antimicrobial and antibacterial properties... By varying the dosage, it is possible to provide the following effect on the pathogenic flora:

• the receipt of funds in a minimum or medium concentration leads to a stop of the reproduction of harmful bacteria. This action is called bacteriostatic;
• approaching the maximum concentration allows the destruction of pathogenic microorganisms. This action is called bactericidal.

Lincomycin has a direct effect on the bacteria that provoked the inflammatory process, helping to suppress the process of protein synthesis in the cells of pathogenic microflora. As a result, the peptide bonds necessary for vital activity are disrupted.

The drug most effectively affects gram-positive microorganisms, which include staphylococci and streptococci, anaerobic bacteria. Separately, it is worth noting the effect on the green streptococcus present in dental plaque, which is one of the main causes of the development of carious processes.

Under the influence of Lincomycin, the microorganism is neutralized. In this case, one can count on a long-term effect, which is explained by the inability of bacteria to quickly acquire resistance to an antibacterial agent.

Lincomycin may be ineffective if the inflammation has developed as a result of exposure to gram-negative bacteria (for example, enterococci), protozoa fungi or viruses that are resistant to this antibiotic.

Lincomycin can be used not only for treatment, but also for prevention purposes, by rinsing, helping to prevent the development of caries.

If the agent is used as part of therapeutic therapy, there is a gradual accumulation in the body of the active substance in the form of lincomycin hydrochloride and its free continuous flow into the inflamed tissues of the tooth or the surrounding gums.

Features of pharmacokinetics

Lincomycin hydrochloride that has entered the body is able to be rapidly absorbed from the gastrointestinal tract and in half of the volume penetrate into the systemic circulation.

After entering the bloodstream, most (75%) of the substance binds to plasma proteins, while the maximum concentration is observed 3 hours after oral administration of the drug.

Lincomycin accumulates in the tissues of organs and fluids, being present in maximum amounts in the kidneys, liver, bone tissue, heart muscle, bronchial secretions and saliva. The active substance is characterized by penetration through the blood-brain barrier and excretion in breast milk.

After metabolism in the liver, the remnants of the drug are excreted unchanged with feces and urine. Half-life occurs within 5-6 hours... In the presence of kidney pathologies, this period may increase.

Composition

The drug consists of lincomycin hydrochloride monohydrate and a number of excipients.

Antibiotic indications

The appointment of Lincomycin is necessary if the following dental disorders are diagnosed:

• the development of infectious inflammation in the tissues of the maxillofacial apparatus;
• the transition of inflammation to a purulent form with the formation of fistulas and abscesses. Usually such phenomena are noted if periodontitis or periodontitis develops. To alleviate the condition, the simultaneous appointment of Lincomycin and Lidocaine is provided;
• severe ulcerative gingivitis;
• inflammation of the tissues of the gums and bone with signs of osteomyelitis.

It is also advisable to use an antibiotic if there is a risk of secondary infection of an open wound formed after tooth extraction.

Forms of release, method of use and dosage

Depending on the purpose of using Lincomycin, it can be purchased in the form of capsules, patches or ampoules with a lyophilisate, by diluting which a solution is obtained for intravenous or intramuscular administration.

Capsules

Capsulated antibacterial agent for adults drink as directed by a doctor, two capsules three times a day (total single dosage - 500 mg). In case of severe inflammation, a four-time dose is possible. The duration of therapy is one to two weeks.

If a dental pathology develops with signs of osteomyelitis, the duration of treatment may increase to at least 3 weeks.

For children, Lincomycin is prescribed in a lower dose, determining the required amount by weight: depending on the nature of the inflammatory process, 30-60 mg of antibiotic per kilogram of weight are provided.

The drug should be taken long before meals. (maintaining an interval of 1.5-2 hours) with sufficient water. Absorption of the antibiotic is most effective if the stomach is not overloaded with food.

When an antibacterial agent is taken almost on an empty stomach, you can count on maximum absorption (the volume of the substance is 30%).

Intramuscular and intravenous injections

Intramuscular administration of Lincomycin is indicated if the dental pathology is severe. To improve the condition of adult patients a maximum of three times a day is administered intramuscularly at 600 mg of the drug.

If intravenous infusion is necessary, the same dosage and frequency of administration of the agent, which is administered by drip, is selected. The antibiotic is pre-diluted with isotonic saline.

It is important that injections or intravenous fluids are given at least 8 hours later.

When treating small patients, the daily amount of antibiotic is determined at the rate of 10-20 mg of lincomycin hydrochloride per kilogram of the child's weight.

When the antibiotic is administered intramuscularly, the needle should penetrate into the muscle tissue as deeply as possible to prevent the formation of blood clots and tissue necrosis.

Patch

Photo: analogue of lincomycin in tablets - patch

In this form, Lincomycin is represented by Diplen-Denta-L patches, which are offered in various versions and differ in the type of film chosen by the dentist, based on the specific clinical picture.

A feature of the patch is its bilateral structure, the presence of hydrophilic and hydrophobic layers that perform the following functions:

• hydrophilic - reliably protects the treated area from the ingress of foreign particles;
• hydrophobic - provides high-quality fixation of the medicinal product on the gums due to the moisture-resistant surface.

The action time of the patch attached to the inflamed area is from 6 to 8 hours, after which it is necessary to carefully remove it.

Side effects and contraindications

The use of an antibacterial agent is not recommended in the following situations:

• there is a hypersensitivity to the active substance;
• impaired kidney or liver function;
• inflammation occurred during pregnancy.

Adverse reaction

Sometimes Lincomycin therapy can cause the following negative reaction of the body:

• malfunction of the hematopoietic system with a noticeable decrease in the number of leukocytes, platelets, neutrophils;
• the appearance of signs of glossitis or stomatitis;
• digestive disorders with the appearance of such signs as pain in the stomach, vomiting and accompanying nausea. Development of colitis, esophagitis, high activity of liver enzymes is possible;
• manifestations of allergies from dermatitis to anaphylactic shock;
• headaches, muscle weakness, disorientation, high blood pressure.

The latter phenomena can occur with intravenous administration of an antibacterial agent.

To avoid deterioration of the general condition lincomycin therapy should be carried out under the strict supervision of a physician, especially in the case of long-term antibiotic use. The indicators are monitored by general urine and blood tests.

During the entire course of treatment, alcoholic beverages should not be consumed.

What can replace the drug? Linosin, Medoglycine, Neloren, Tsilimycin - these analogs are similar in composition to Lincomycin, but they should be prescribed exclusively by the attending physician.

Price

The change in the cost of Lincomycin occurs when choosing various forms of an antibacterial drug.

1. Lyophilisate for intravenous drip or injection costs on average 40-50 rubles, a similar price is typical for capsules taken orally.
2. The most expensive is the lincomycin patch, which costs about 400-500 rubles.

Composition and release form of the drug

2 ml - ampoules (5) - contoured cell packs (2) - cardboard packs.

pharmachologic effect

Antibiotic of the lincosamide group. In therapeutic doses, it acts bacteriostatically. At higher concentrations, it has a bactericidal effect. Suppresses protein synthesis in the microbial cell.

It is mainly active against aerobic gram-positive bacteria: Staphylococcus spp. (including strains producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae / with the exception of Enterococcus faecalis /), Corynebacterium diphtheriae; anaerobic bacteria Clostridium spp., Bacteroides spp.

Lincomycin is also active against Mycoplasma spp.

Most gram-negative bacteria, fungi, viruses, protozoa are resistant to lincomycin. Resilience is developing slowly.

Cross-resistance exists between lincomycin.

Pharmacokinetics

After oral administration, 30-40% is absorbed from the gastrointestinal tract. Food intake slows down the rate and extent of absorption. Lincomycin is widely distributed in tissues (including bone) and body fluids. Penetrates the placental barrier. Partially metabolized in the liver. T 1/2 is about 5 hours. It is excreted unchanged and in the form of metabolites in urine, bile and feces.

Indications

Infectious and inflammatory diseases of severe course caused by microorganisms sensitive to lincomycin, incl. sepsis, osteomyelitis, septic endocarditis, pneumonia, lung abscess, pleural empyema, wound infection. As a reserve antibiotic for infections caused by strains of staphylococcus and other gram-positive microorganisms resistant to penicillin and other antibiotics.

For external use: purulent-inflammatory skin diseases.

Contraindications

Severe liver and / or kidney dysfunction, pregnancy, lactation, hypersensitivity to lincomycin and clindamycin.

Dosage

When taken orally by adults - 500 mg 3-4 times / day or i / m - 600 mg 1-2 times / day. Intravenous drip is injected at 600 mg in 250 ml of isotonic solution or glucose 2-3 times / day.

Children aged 1 month to 14 years by mouth - 30-60 mg / kg / day; intravenous drip is injected at a dose of 10-20 mg / kg every 8-12 hours.

When applied externally, apply in a thin layer to the affected skin.

Side effects

From the digestive system: nausea, vomiting, epigastric pain, diarrhea, glossitis, stomatitis; a transient increase in the level of hepatic transaminases and bilirubin in the blood; with prolonged use in high doses, the development of pseudomembranous colitis is possible.

From the hematopoietic system: reversible leukopenia, neutropenia, thrombocytopenia.

Allergic reactions: urticaria, exfoliative dermatitis, Quincke's edema, anaphylactic shock.

Effects due to chemotherapeutic action: candidiasis.

Local reactions: phlebitis (with intravenous administration).

With a rapid intravenous injection: lowering blood pressure, dizziness, general weakness, relaxation of skeletal muscles.

Drug interactions

With simultaneous use with penicillins, cephalosporins, chloramphenicol, or antagonism of antimicrobial action is possible.

With simultaneous use with aminoglycosides, synergism of action is possible.

With simultaneous use with agents for inhalation anesthesia or peripheral action, an increase in neuromuscular blockade is noted, up to the development of apnea.

Taking antidiarrheal drugs reduces the effect of lincomycin.

Pharmaceutical interactions

Pharmaceutically incompatible with ampicillin, barbiturates, theophylline, heparin and magnesium sulfate.

Lincomycin is incompatible with kanamycin or novobiocin in the same syringe or dropper.

special instructions

In case of impaired liver and / or kidney function, a single dose of lincomycin should be reduced by 1 / 3-1 / 2 and the interval between injections should be increased. With prolonged use, systematic monitoring of kidney and liver function is required. Contraindicated in severe renal dysfunction.

In case of impaired renal function, a single dose of lincomycin should be reduced by 1/3 - 1/2 and the interval between injections should be increased. With prolonged use, systematic monitoring of renal function is necessary.

For violations of liver function

Contraindicated in severe liver dysfunction.

In case of impaired liver function, a single dose of lincomycin should be reduced by 1/3 - 1/2 and the interval between injections should be increased. With prolonged use, systematic monitoring of liver function is necessary.

Structural formula

Russian name

Latin name of the substance Lincomycin

Lincomycinum ( genus. Lincomycini)

Chemical name

(2S-trans) -Methyl-6,8-dideoxy-6 - [[(1-methyl-4-propyl-2-pyrrolidinyl) carbonyl] amino] -1-thio-D-erythro-alpha-D-galacto- octopyranoside (and as monohydrochloride)

Gross formula

C 18 H 34 N 2 O 6 S

Pharmacological group of the substance Lincomycin

Nosological classification (ICD-10)

CAS code

154-21-2

Characteristics of the substance Lincomycin

An antibiotic of the lincomycin group (lincosamides) produced by Streptomyces lincolnensis or other related actinomycetes. White or almost white crystalline powder of bitter taste. Let's easily dissolve in water, it is difficult - in alcohol.

Pharmacology

pharmachologic effect - antibacterial.

Suppresses bacterial protein synthesis due to reversible binding with the 50S ribosome subunit, disrupts the formation of peptide bonds. Effective against gram-positive microorganisms ( Staphylococcus spp., Streptococcus spp., incl. Streptococcus pneumoniae, Corynebacterium diphtheriae), some anaerobic spore-forming bacteria ( Clostridium spp.) and gram-negative anaerobes ( Bacteroides spp., Mycoplasma spp.). Acts on microorganisms (especially Staphylococcus spp.), resistant to other antibiotics. Not sensitive to lincomycin Enterococcus spp. (incl. Enterococcus faecalis), gram-negative microorganisms, fungi, viruses, protozoa. It is inferior in activity to erythromycin against spore-forming anaerobes, Neisseria spp., Corynebacterium spp. Resistance develops slowly. Cross-resistance exists between lincomycin and clindamycin. In therapeutic doses, it has a bacteriostatic effect, in higher and against highly sensitive microorganisms - bactericidal.

When taken orally on an empty stomach, about 20-30% of the dose is absorbed (food intake significantly reduces absorption, bioavailability when taken after meals is 5%), C max in the blood is reached after 2-4 hours.It is well and quickly distributed into most tissues and fluids organism (except for the cerebrospinal fluid), high concentrations are created in bile and bone tissue. Poorly passes through the BBB. It quickly passes through the placenta, the fetal serum concentration is 25% of the concentration in the mother's blood. Penetrates into breast milk. Metabolized in the liver. T 1/2 with normal renal function - 4-6 hours, with kidney disease in the terminal stage - 10-20 hours, with impaired liver function T 1/2 increases by 2 times. It is excreted unchanged and in the form of metabolites in the bile and kidneys. When taken orally, 30-40% of the dose is excreted unchanged with feces within 72 hours. Hemodialysis and peritoneal dialysis are not effective for removing lincomycin from the body.

Application of the substance Lincomycin

Infectious and inflammatory diseases of a severe course caused by sensitive microorganisms (primarily staphylococci and streptococci, especially microorganisms resistant to penicillins, as well as with allergies to penicillins): lower respiratory tract infections (including aspiration pneumonia, lung abscess, pleural empyema ), otitis media, infections of bones and joints (acute and chronic osteomyelitis, purulent arthritis), purulent infections of the skin and soft tissues (pyoderma, furunculosis, phlegmon, erysipelas, wound infection).

Contraindications

Hypersensitivity, severe hepatic and / or renal failure, early infancy (up to 1 month).

Restrictions on use

Fungal diseases of the skin, mucous membranes of the mouth, vagina; myasthenia gravis (for parenteral administration, optional).

Application during pregnancy and lactation

Contraindicated in pregnancy (except when it is necessary for health reasons).

During treatment, breastfeeding should be discontinued.

Side effects of the substance Lincomycin

From the digestive tract: nausea, vomiting, diarrhea, abdominal pain, glossitis, stomatitis, transient hyperbilirubinemia, increased activity of hepatic transaminases; with prolonged use - gastrointestinal candidiasis, antibiotic-associated diarrhea, pseudomembranous enterocolitis.

From the side of the hematopoietic organs: reversible leukopenia, thrombocytopenia, neutropenia.

Allergic reactions: urticaria, exfoliative dermatitis, angioedema, anaphylactic shock.

Others:local reactions with intravenous administration - phlebitis; with rapid intravenous administration - lowering blood pressure, dizziness, asthenia, relaxation of skeletal muscles.

Interaction

Antagonism is possible with simultaneous use with erythromycin, chloramphenicol, ampicillin and other bactericidal antibiotics, synergism with aminoglycosides. Antidiarrheal drugs reduce the effect of lincomycin (the interval between their use should be at least 4 hours). Enhances the effect of drugs for inhalation anesthesia, muscle relaxants and opioid analgesics, increasing the risk of neuromuscular blockade and respiratory arrest. Pharmaceutically incompatible with kanamycin.

Route of administration

Inside, i / v, i / m, locally.

Precautions for the substance Lincomycin

Should not be combined with muscle relaxants. For severe infections, lincomycin is combined with aminoglycosides or other antibiotics that act on gram-negative bacteria. Prescribing to patients with hepatic insufficiency is permissible only for health reasons. With prolonged use, systematic monitoring of kidney and liver function is necessary. If pseudomembranous colitis develops, the administration is discontinued and vancomycin or bacitracin is prescribed. Rapid IV administration should be avoided. When applied topically, care should be taken with dermatomycosis.

Interaction with other active ingredients

Related news

Trade names

Name	Value of the Vyshkovsky Index ®

Lincomycin is a drug with antibacterial action.

Release form and composition

Lincomycin is available in the following forms:

• Capsules (10 or 20 pcs. In dark glass or polymer jars, 1 can in a cardboard box; 10 pcs. In blisters, 1, 2, 150 packs in a cardboard box);
• Solution for intravenous and intramuscular administration (1 or 2 ml in ampoules complete with an ampoule knife, 10 ampoules in a cardboard box or 5 or 10 ampoules in blisters, 1 or 2 packages in a cardboard box).

1 capsule contains:

• Active ingredient: lincomycin hydrochloride monohydrate - 250 mg (in terms of lincomycin);
• Auxiliary components: potato starch, sucrose (powdered sugar).

The composition of the capsule shell: sodium lauryl sulfate, water, gelatin, propylparaben (propyl parahydroxybenzoate), methylparaben (methyl parahydroxybenzoate), dyes: sunset yellow dye (E 110), quinoline yellow (E 104), titanium dioxide.

The active ingredient is a part of 1 ml of solution for injection: lincomycin hydrochloride - 300 mg.

Indications for use

Lincomycin is prescribed for the treatment of the following infectious and inflammatory diseases caused by microorganisms sensitive to the action of the active substance (first of all, streptococci and staphylococci, especially microorganisms showing resistance to penicillins, as well as in the presence of allergy to penicillins):

• Otitis;
• Subacute septic endocarditis;
• Sepsis;
• Postoperative purulent complications;
• Chronic pneumonia;
• Wound infections;
• Empyema of the pleura;
• Lung abscess;
• Pleurisy;
• Purulent arthritis;
• Osteomyelitis (chronic and acute).

Also, the drug is indicated for infections of soft tissues and skin, including furunculosis, pyoderma, erysipelas and phlegmon.

Contraindications

• Hepatic renal failure;
• Pregnancy;
• Hypersensitivity to drug components.

Additionally, contraindications to the use of Lincomycin in capsule form are:

• Lactation period;
• Age up to 3 years.

Capsules should be taken with caution in patients with fungal diseases of the oral mucosa, skin and vagina.

Method of administration and dosage

Lincomycin in the form of capsules should be taken orally, observing the intervals with meals (1-2 hours before or 2-3 hours after meals).

The frequency of taking the drug is 2-3 times a day with equal intervals (8-12 hours).

For adults, Lincomycin is prescribed in a single dose of 500 mg (1000-1500 mg per day). The daily dose for children 3-14 years old is 30-60 mg / kg.

The duration of therapy is determined by the form and severity of the disease. On average, it is 1-2 weeks; in the treatment of osteomyelitis, a longer treatment is possible (from 3 weeks).

When carrying out repeated courses of therapy or with prolonged treatment, it is necessary to monitor the functional state of the kidneys and liver.

Intramuscularly a solution of Lincomycin for adults should be administered 2 times a day, 500 mg. In severe cases, it is possible to use the drug 3 times a day.

For children, Lincomycin is prescribed in a daily dose of 15-30 mg / kg in 2 administrations.

Intravenous drip administration of the drug (60-80 drops per minute) is also possible at a dose of 600 mg 3 times a day.

The duration of the course is 1-2 weeks, in some cases, treatment is carried out within a month.

Side effects

During therapy, the following side effects may develop:

• Hematopoietic organs: thrombocytopenia, reversible leukopenia and neutropenia;
• Digestive system: epigastric pain, nausea, diarrhea, vomiting, increased activity of hepatic transaminases, abdominal pain, stomatitis, glossitis, transient hyperbilirubinemia; with prolonged use - pseudomembranous enterocolitis, candidiasis of the gastrointestinal tract. It is also possible to develop other fungal infections of the genital tract;
• Allergic reactions: exfoliative dermatitis, urticaria, anaphylactic shock, angioedema.

special instructions

To achieve optimal absorption from the gastrointestinal tract, it is not recommended to eat within 1–2 hours before and after taking Lincomycin.

Patients with functional disorders of the kidneys and / or liver, a single dose of the drug should be reduced by 1 / 3-1 / 2, and the interval between doses should be increased. For patients with hepatic insufficiency, therapy is possible only for health reasons.

With prolonged use of Lincomycin, it is necessary to systematically monitor the function of the liver and kidneys.

Lincomycin is not recommended for the treatment of meningitis.

With the development of symptoms of pseudomembranous enterocolitis (excretion with fecal masses of blood and mucus, leukocytosis, diarrhea, abdominal pain, fever) in mild cases, it is sufficient to cancel Lincomycin and prescribe ion exchange resins (colestyramine). In severe cases of the disease, it is shown that the loss of fluid, protein and electrolytes is replaced by oral administration of vancomycin (in a daily dose of 500-2000 mg (for 3-4 doses) for 10 days) or bacitracin.

Drug interactions

Lincomycin exhibits:

• Antagonism: with chloramphenicol, erythromycin, ampicillin and other bactericidal antibiotic drugs;
• Synergism: with aminoglycosides.

The drug is chemically incompatible with kanamycin and novobiocin, so they should not be administered in the same syringe or dropper. Rating: 4.6 - 32 votes

Lincomycin is a broad-spectrum antibiotic that is used to treat diseases provoked by the activity of most gram-positive bacteria.

When taking therapeutic doses of the drug, it acts bacteriostatically, and in higher concentrations has a pronounced bactericidal effect on the body.

In this article, we will consider why doctors prescribe Lincomycin, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Lincomycin can be read in the comments.

Composition and form of release

It is produced in the form of capsules and a solution contained in ampoules. The package can contain 6, 10 and 20 capsules of 250 mg. The ampoules can hold 1 ml or 2 ml of solution. Lincomycin-AKOS ointment is also produced, which is sold in tubes of 10 and 15 g.

• active substance: lincomycin (in the form of lincomycin hydrochloride) - 300 mg;
• excipients: disodium edetate, sodium hydroxide 1 M solution, water for injection.

Pharmacological action: antimicrobial agent, which belongs to the group of lincosamides.

What does Lincomycin help with?

Lincomycin according to the instructions is used to treat severe infectious and inflammatory diseases, including:

• infection with microorganisms sensitive to the agent;
• infections of bones and joints;
• infections of the respiratory tract and ENT organs (pneumonia, sinusitis, otitis media, acute bronchitis);
• infections of the skin or soft tissues (abscess, furunculosis, erysipelas, mastitis, infected wounds).
• staphylococcal infections;
• septic process (the presence of microbes in the blood);
• osteomyelitis (inflammation of the bone marrow and adjacent bone tissue).

In dentistry, Lincomycin is prescribed for the treatment of various infections of the maxillofacial system. As a rule, dentists prefer this drug for its ability to be deposited in teeth and bone tissue.

Common use of Lincomycin in dentistry in combination with lidocaine for the treatment of purulent processes in periodontitis, gingivitis, periodontitis. Since there are no direct indications for the use of Lincomycin in dentistry, the question of prescribing the drug should be resolved only with the attending physician.

pharmachologic effect

Lincomycin, being an antibiotic, is active in therapeutic doses against:

• Streptococcus spp. Including Streptococcus pneumoniae;
• Bacteroides spp .;
• Mycoplasma spp .;
• Corynebacterium diphtheriae;
• Clostridium spp;
• Staphylococcus spp., Including strains that produce penicillinase.

Does not work on Enterococcus spp (including Enterococcus faecalis), gram-negative microorganisms, fungi, viruses, protozoa; inferior in activity to erythromycin against spore-forming anaerobes, Neisseria spp., Corynebacterium SPP.

Instructions for use

According to the instructions for use, Lincomycin is taken orally on an empty stomach 30-60 minutes before meals or 2 hours after meals with plenty of liquid. Capsules cannot be divided or opened.

• Adults are prescribed 0.5 g every 8 hours for moderate infections; 0.5 g every 6 hours for severe infection (2 g / day).
• Children aged 6-14 years with a body weight\u003e 25 kg are prescribed in a daily dose at the rate of 30 mg / kg body weight in 3-4 doses, in severe cases - 60 mg / kg body weight in 3-4 doses.

The duration of the course of treatment is 7-14 days, with osteomyelitis - ≥3 weeks. In case of impaired liver and / or kidney function, it is necessary to reduce the daily dose of Lincomycin by 1 / 3-1 / 2 and increase the interval between doses.

Contraindications

You can not use the drug in such cases:

1. Functional disorders of the liver in severe form;
2. Hypersensitivity to Lincomycin and its components;
3. Simultaneous use of Lincomycin with drugs that relax the muscles;
4. Simultaneous use of Lincomycin with inhalation agents for anesthesia;
5. Individual intolerance to Lincomycin and its components;
6. Pregnancy and lactation period;
7. Patients under 6 years of age;
8. Functional kidney failure in severe form.

Side effects

When using Lincomycin in ampoules and capsules, patients may experience the following side effects:

1. Diarrhea.
2. Stomatitis.
3. Quincke's edema.
4. Phlebitis.
5. Pain in the lower abdomen.
6. Nausea and vomiting.
7. An increased amount of liver enzymes in the blood.
8. Anaphylactic shock.
9. Hives.
10. Dizziness.
11. Lethargy.
12. Inhibited reaction.
13. Pseudomembranous colitis (may develop with prolonged use of the drug).
14. Decrease in the number of leukocytes and platelets in the blood.

Pregnancy and lactation

Lincomycin crosses the placental barrier, excreted in breast milk. Pregnancy is contraindicated. If necessary, use during lactation should decide on the termination of breastfeeding.

Analogs

Analogues of the antibiotic Lincomycin are drugs Lincomycin hydrochloride, Linkocin Clindamycin, Dalacin C, Clindamycin-Norton, etc.

Attention: the use of analogs must be agreed with the attending physician.