Thiamin (vitamin B1), solution for injection (ampoules). Medicinal guide geotar Thiamin intravenously

Dosage Form: & nbspsolution for intramuscular injection Composition:

1 ml of solution contains:

active substance: thiamine hydrochloride - 50 mg;

auxiliary substances: sodium dimercaptopropanesulfonate monohydrate (unitiol) - 2 mg, edetate disodium - 0.2 mg, water for injection.

Description:

Colorless or slightly colored transparent liquid with a faint characteristic odor.

Pharmacotherapeutic group:vitamin ATX: & nbsp

A.11.D.A.01 Thiamine

Pharmacodynamics:

Vitamin B1 () refers to water-soluble vitamins. In the body, as a result of phosphorylation processes, it turns into cocarboxylase, which is a coenzyme of many enzymatic reactions.

Plays an important role in carbohydrate, protein and fat metabolism, as well as in the processes of conduction of nervous excitation in synapses.

Pharmacokinetics:

In the blood, the concentration is relatively low, while in the plasma it circulates mainly free, in erythrocytes and leukocytes - its phosphorus esters. Phosphorylation occurs in the liver. The most active phosphoric ester is thiamine diphosphate, which has coenzyme activity. It accumulates mainly in the liver, heart, brain, kidneys, spleen. 1/2 of the total amount is contained in striated muscles and myocardium and about 40% in internal organs. It is excreted through the intestines and kidneys.

Indications:

Hypovitaminosis and vitamin deficiency B1.

As part of complex therapy:

Neuritis, radiculitis, neuralgia; peripheral paresis and paralysis;

Peptic ulcer and 12 duodenal ulcer; anorexia, intestinal atony, atonic constipation;

Myocardial dystrophy; violation of the coronary circulation;

Dermatoses (eczema, neurodermatitis, psoriasis, lichen planus) with neurotrophic changes and metabolic disorders.

Contraindications:

Increased individual sensitivity, pregnancy, lactation, childhood.

Carefully:Wernicke's encephalopathy, a woman in the premenopausal and climacteric periods. Method of administration and dosage:

Thiamine solution is injected intramuscularly (deep into the muscle).

Side effects:

Allergic reactions are possible (urticaria, pruritus, Quincke's edema, anaphylactic shock), increased sweating, tachycardia.

Sometimes soreness (due to low pH of the solution) at the injection site.

Interaction:

Simultaneous parenteral administration of thiamine and pyridoxine (vitamin Bb) or cyanocobalamin (vitamin Bi2) is not recommended. B12 enhances the allergenic effect of thiamine. Wb complicates the conversion of thiamine into a biologically active form. Vitamin Bi and or (destruction of antibiotics), vitamin Bi and nicotinic acid (destruction of vitamin Bi) should not be mixed in one syringe. reduces the pharmacological activity of suxamethonium iodide, phentolamine, propranolol, sympatholytics (), hypnotics (hypnotic and hypotensive effects decrease).

The thiamine solution should not be mixed with solutions containing sulfites, because in them it completely disintegrates.

Thiamine is unstable in alkaline and neutral solutions; appointment with carbonates, citrates, barbiturates, copper preparations is not recommended.

Special instructions:

When determining theophylline in blood serum by the spectrophotometric method, urobilinogen using Ehrlich's reagent can distort the results (when taking high doses). More often anaphylactic reaction develops after intravenous administration of large doses.

In Wernicke's encephalopathy, the administration of dextrose should precede the administration of thiamine.

Release form / dosage:

Solution for intramuscular injection of 50 mg / ml.

Packaging:

Solution for intramuscular injection 50 mg / ml. 1 ml in neutral glass ampoules. 5 ampoules in a PVC blister strip packaging. 1 or 2 blister packs together with an ampoule knife or a ceramic ampoule scarifier and instructions for use are placed in a pack. 10 ampoules in a cardboard box together with an ampoule knife or ceramic ampoule scarifier and instructions for use. When packing ampoules with notches, the ampoule knife or scarifier is not inserted.

Storage conditions:

In a dark place at a temperature of 0 to 25 ° C.

Keep out of the reach of children.

Shelf life: 3 years. Do not use after the expiration date. Terms of dispensing from pharmacies:On prescription Registration number:R N001066 / 01 Registration date:12.12.2008 Marketing Authorization Holder:MOSKHIMPHARMOPREPARATY them. N.A. Semashko, JSC Thiamine chloride

Composition

International and chemical names: thiamine, vitamin B1, 3 - [(4-amino-2-methyl-5-pyrimidinyl) methyl] -5- (2-hydroxyethyl) -4-methyl-thiazolium chloride hydrochloride; basic physical and chemical properties: colorless transparent or slightly yellowish liquid.

1 ml of the preparation contains thiamine chloride (in terms of 100% substance) 50.0 mg; excipients: unitiol, water for injection.

pharmachologic effect

Pharmacodynamics
Thiamine Chloride is a synthetic preparation of vitamin B1, belongs to water-soluble vitamins. In the human body, as a result of phosphorylation processes, it turns into cocarboxylase, which is a coenzyme of many enzymatic reactions. Vitamin B1 plays an important role in carbohydrate, protein and fat metabolism, as well as in the processes of conduction of nervous excitement in synapses.

Pharmacotnetics
The drug, when administered parenterally, quickly enters the bloodstream, more or less evenly distributed between organs and tissues. Phosphorylation occurs in the liver. It accumulates in the liver, heart, brain, kidneys, spleen. It is excreted by the liver and kidneys, about 8-10% - unchanged.

Indications for use

Thiamine Chloride is used for the treatment of B1 hypo- and avitaminosis, for the treatment of neuritis, polyneuritis, radiculitis, neuralgia, peripheral paralysis, encephalopathy, neurasthenia, peptic ulcer of the stomach and duodenal ulcer, intestinal atony, liver diseases, myocardial dystrophy, vascular spasms ( endarteritis, etc.), dermatoses of neurogenic origin, with itchy skin, pyoderma, eczema, psoriasis.

Side effects

Allergic reactions (pruritus, urticaria, Quincke's edema), anaphylactic shock are possible. These reactions occur with a tendency to allergies, in women in the climacteric and premenopausal periods, in patients with alcoholism.

Contraindications

Hypersensitivity, allergic diseases, idiosyncrasy, hypertension. Prescribe with caution in case of increased excitability of the nervous system, duodenal ulcer (hyperacid forms).

Pregnancy

When using the drug by pregnant and lactating women, no negative effects have been identified.

Drug interactions

Thiamine Chloride solution should not be mixed with solutions containing sulphites, as it completely decomposes in them. The simultaneous parenteral administration of Thiamine Chloride with vitamin B6 (pyridoxine) and vitamin B12 (cyanocobalamin) is not recommended, since, accordingly, the former enhances the allergenic effect of thiamine, and the latter inhibits its conversion into a phosphorylated biologically active form.
Thiamine Chloride should not be mixed with penicillin or streptomycin (antibiotic destruction occurs), as well as Thiamine Chloride and nicotinic acid (thiamine destruction occurs) in the same syringe.

Long-term treatment with anticonvulsants (phenobarbital, phenytoin, carbamazepine), as well as the combined use of the drug with digoxin, indomethacin, antacid drugs, can lead to thiamine deficiency. Thiosemicarbazone and 5-fluorofuranyl inhibit the activity of vitamin B1. The use of caffeine, preparations containing sulfur and estrogens, increases the need for thiamine. Thiamine weakens the curariform effect of depolarizing muscle relaxants (ditilin and others).

Overdose

In case of an overdose, the symptoms of side effects of the drug may increase. When used in large doses for a long time, signs of hyperthyroidism may appear: headache, agitation, tremor, increased heart rate, insomnia.
Treatment: stop taking the drug; treatment is symptomatic.

Release form

Injection.
1 ml ampoules; 10 ampoules per pack.

Storage conditions

Store out of the reach of children, protected from light, at a temperature not exceeding 25 ° C.
Shelf life is 3 years.
Dispensed by prescription.

Synonyms

Vitamin B1

Active substance:

Thiamine chloride

Additionally

The injectable form of the drug must be used in the treatment of patients with intestinal absorption disorders, as well as in severe forms of the disease or from the beginning of treatment for a faster achievement of the therapeutic effect. It is recommended to start parenteral administration of Thiamine Chloride with small doses (no more than 0.5 ml of a 5% solution), and higher doses are administered only with good tolerance. With intramuscular injection, the drug should be injected deep into the muscle, with intravenous injection - slowly. Subcutaneous and sometimes intramuscular injections are painful due to the low pH of the solutions. In women in the climacteric and premenopausal periods, as well as in patients with alcoholism, the symptoms of side effects of the drug may increase.

Manufacturer
LLC "Pharmaceutical company" Health "

Authors

Links

• Official instruction for the preparation Thiamine chloride.
• Modern Medicines: A Complete Practical Guide. Moscow, 2000.S. A. Kryzhanovsky, M. B. Vititnova.

Attention!
Description of the drug " Thiamine chloride"on this page is a simplified and supplemented version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and familiarize yourself with the annotation approved by the manufacturer.
The information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide on the appointment of the drug, as well as determine the doses and methods of its use.

Thiamine chloride is essential for patients with metabolic disorders. It is advisable to use in consultation with a doctor.

International non-proprietary name

The Latin name is Thiamine chloride.

ATX and registration number

The ATX code is A11DA01. The registration number of the medicine is P N015467 / 01.

Pharmacotherapeutic group

Belongs to the group of agents for normalizing the patient's metabolism.

Mechanism of action

Pharmacodynamics of the drug: vitamin b1 belongs to the water-soluble group. The phosphorylation processes occurring in the body contribute to its conversion into cocarboxylase, which regulates many enzymatic reactions in the human body.

Thiamine chloride helps normal protein, fat and carbohydrate metabolism. Vitamin also takes part in the processes of nervous excitement, which take place in synapses.

Pharmacokinetics of the drug: the concentration in the blood when taking the drug can be characterized as low, but the blood plasma contains a lot of free vitamin. The phosphorylation process takes place in the liver. It is maximally concentrated in the liver, brain, spleen, kidneys and heart. Excretion occurs through the kidneys and intestines.

Composition and form of release

The medicine can be purchased only in the form of a solution for intramuscular administration. 1 ampoule with 1 ml of solution contains 50 mg of thiamine chloride. Each box contains 10 ampoules. The product is not produced in the form of tablets.

Indications for use

Thiamine chloride should be prescribed to patients with the following pathologies:

• , eczema;
• disorders of absorption in the intestine;
• thyrotoxicosis;
• neuritis, radiculitis, neuralgia;
• myocardial dystrophy;
• paralysis;
• intestinal atony;
• pathology of the coronary circulation;
• peripheral paresis;
• hypovitaminosis and vitamin deficiency.

Contraindications

The drug should not be used if the patient has an increased susceptibility to thiamine.

How to apply?

Patients should read the instructions for use of the drug. The dosage should be indicated by the doctor who prescribes the remedy. Below will be presented indicative doses for use in various diseases.

A 5% thiamine solution is administered intramuscularly (injections). At the beginning of therapy, treatment with small doses of the drug is recommended. This is no more than 0.5 ml of a solution of the indicated concentration. If the patient tolerates this treatment well, the injection dose can be increased. The treatment course is 10-30 injections.

special instructions

Thiamine chloride ampoules can be used to improve hair condition. At the same time, it is important in addition to such treatment to properly care for your hair.

During pregnancy and lactation

Carrying a child and breastfeeding are not contraindications for therapy with this drug.

In childhood

Prescribing to children is done with caution, the dosage is 0.0125 g for 1 month.

In old age

Old age should not become a reason for a ban on taking the drug. The only thing to keep in mind is that additional supervision by the doctor is needed.

For violations of liver function

Hepatic pathologies are not a contraindication for treatment with a drug.

With impaired renal function

Side effects of the drug Thiamine chloride

As side reactions may occur:

• allergic reactions (urticaria, Quincke's edema, pruritus, anaphylactic shock);
• tachycardia and sweating;
• soreness at the injection site.

Impact on vehicle handling

The drug does not adversely affect the patient's ability to operate the machine.

Overdose

Thiamine chloride drug interactions

Thiamine tends to reduce the pharmacological activity of redergam, hypnotics (hypotensive and hypnotic effects become less pronounced), phentolamine, suxamethonium iodide, sympatholytics such as octadine and reserpine.

It is not recommended to combine parenteral administration of thiamine and,. The latter vitamin contributes to a more pronounced manifestation of allergic reactions caused by treatment with vitamin b1. Pyridoxine makes it difficult to transform thiamine into a biologically active form.

Thiamine cannot be combined with solutions that contain sulfites (it completely decomposes). Also, the combination with is not recommended, since the breakdown of thiamine occurs.

Alcohol compatibility

It is undesirable to take alcoholic beverages during treatment.

Conditions for dispensing Thiamine chloride from pharmacies

It is dispensed only by prescription.

Price

The cost of the drug is low and starts from 40 rubles in Russia.

Storage conditions

Storage should be carried out in a dark place at room temperature.

Shelf life

Description of the dosage form

Thiamine

Latin name
Dosage form

Injection

Composition

1 ml of the drug contains 0.050 g of thiamine chloride

Packaging

10 ampoules of 1 ml.

pharmachologic effect

Thiamine plays an important role in the life of the body, is part of a number of enzymes and is involved in carbohydrate metabolism, in the processes of decarboxylation of a-keto acids and the synthesis of acetyl CoA. It has an effect on the conduct of nervous excitement in synapses, has ganglion-blocking and curariform properties. It is of great importance for the function of the nervous system, digestive apparatus, cardiac activity, and also the endocrine system. A source of thiamine for humans is food. In the absence or inadequate intake of it with food or under various conditions that prevent its absorption and assimilation, the person develops the phenomena of hypo- and avitaminosis B1. The initial stages of vitamin B1 deficiency are characterized by nervous disorders (neurasthenia, headaches, migraines, fatigue, insomnia, pain and sensory disturbances in the limbs, muscle weakness, cramps in the calves), disorders of the cardiovascular system (shortness of breath, expansion of the heart, rhythm disturbance) and digestive organs (anorexia, intestinal atony, constipation). Avitaminosis B1, called beriberi, proceeds either with paralysis and exhaustion, or with heart damage and edema. Thiamine taken orally is absorbed in the small intestine, partially undergoing inactivation by thiaminase.

Indications

Hypovitaminosis and vitamin B1 deficiency, incl. in patients on tube feeding, hemodialysis, with malabsorption syndrome. As part of complex therapy - neuritis and polyneuritis, sciatica, neuralgia, peripheral paresis and paralysis, Wernicke's encephalopathy, Korsakov's psychosis, chronic liver damage, various intoxications, myocardial dystrophy, coronary artery disease, gastric ulcer and duodenal ulcer, atonic constipation intestines; thyrotoxicosis, diabetes mellitus, endarteritis; dermatoses (eczema, atopic dermatitis, psoriasis, lichen planus) with neurotrophic changes and metabolic disorders; pyoderma.

Contraindications

Hypersensitivity.

Method of administration and dosage

Intramuscularly (deep into the muscle). It is recommended to start parenteral administration with small doses (no more than 0.5 ml of a 5 or 2.5% solution), and only with good tolerance, higher doses are administered. Adults are prescribed 0.02-0.05 g of thiamine chloride (1 ml of 2.5 or 5% solution) once a day, every day; children are injected with 0.0125 g (0.5 ml of a 2.5% solution) of thiamine chloride. The course of treatment is 10-30 injections.

Side effects

Allergic reactions (urticaria, pruritus, Quincke's edema, rarely - anaphylactic shock), sweating, tachycardia. Rarely soreness (due to low pH of solutions).

special instructions

Parenteral administration is recommended only if oral administration is not possible (nausea, vomiting, malabsorption syndrome, preoperative or postoperative conditions). In Wernicke's encephalopathy, the administration of dextrose should precede the administration of thiamine.

Interaction

Thiamine chloride solution should not be mixed with solutions containing sulfites, as in them it completely disintegrates. Simultaneous parenteral administration of thiamine with pyridoxine or cyanocobalamin is not recommended: pyridoxine makes it difficult to convert thiamine into a biologically active form, cyanocobalamin enhances the allergenic effect of thiamine. Thiamine and penicillin or streptomycin (destruction of antibiotics), thiamine and nicotinic acid (destruction of thiamine) should not be mixed in the same syringe. Weakens the effect of depolarizing muscle relaxants (suxamethonium iodide, etc.).

Storage conditions

Store in a dry place at a temperature not exceeding 25 ° C, out of the reach of children.

Shelf life