Application in childhood.

Active substance

Pyrantel

Release form, composition and packaging

Oral suspension light yellow in color, with a characteristic odor; separation into a liquid layer and sediment is allowed, after shaking a homogeneous suspension is formed.

Excipients: sodium benzoate - 15 mg, sodium carmellose - 15 mg, sorbitol 70% (non-crystallizing) - 3605 mg, glycerol - 303.5 mg, magnesium aluminosilicate - 16.5 mg, polysorbate 80 - 10 mg, K25 - 100 mg, citric acid monohydrate - 1.5 mg, simethicone emulsion - 2.5 mg, fruit flavor - 2.5 mg, water - up to 5 ml.

5 ml - bottles (1) complete with a measuring cup or measuring spoon - cardboard packs.
10 ml - bottles (1) complete with a measuring cup or measuring spoon - cardboard packs.
15 ml - bottles (1) complete with a measuring cup or measuring spoon - cardboard packs.
25 ml - bottles (1) complete with a measuring cup or measuring spoon - cardboard packs.

pharmachologic effect

An anthelmintic drug, causes a neuromuscular blockade of helminths that are sensitive to it and ensures their expulsion without excitation and stimulation of the migration of the affected worms. Acts on both sexually mature and immature individuals of both sexes. Is active against Enterobius vermicularis, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus.

Pharmacokinetics

Practically not absorbed from the gastrointestinal tract. After taking a single dose of 10 mg / kg, the concentration is 0.005-0.13 μg / ml and is reached within 1-3 hours. It is metabolized partially in the liver to N-methyl-1,3-propanediamine. Excretion by the intestines - about 93% unchanged, 7% - by the kidneys and unchanged or as a metabolite.

Indications

• ascariasis;
• enterobiasis;
• ankylostomiasis (including non-kotorosis).

Contraindications

Dosage

For oral administration.

The suspension is shaken before use.

1 ml of suspension contains 50 mg of pyrantel.

Can be taken at any time of the day, not necessarily on an empty stomach. Do not use laxatives before and after taking the drug.

Ascariasis, enterobiasis:

With enterobiasis, as well as mixed invasions (enterobiasis and ascariasis), the dose intended for the entire course (at the rate of 10 mg / kg of body weight) is applied once.

Children from 6 months to 2 years old: 2.5 ml suspension (125 mg);

Children from 2 years of age weighing more than 12 kg to 6 years: 5 ml suspension (250 mg);

Children from 6 to 12 years old: 10 ml suspension (500 mg);

Children over 12 years old and adults weighing less than 75 kg: 15 ml suspension (750 mg);

Adults weighing more than 75 kg: 20 ml suspension (1000 mg).

With isolated ascariasis - 5 mg / kg once.

Ankylostomiasis:

In endemic areas, in case of infection with Necalor americanus or in case of severe infection with Ancylostoma duodenale, the dosage is 20 mg / kg / day (in one or two doses) for two to three days.

In case of infection with Ancylostoma duodenale outside the endemic zones (it proceeds more easily), it is used at a dose of 10 mg / kg at a time.

Side effects

From the digestive tract:nausea, vomiting, diarrhea, loss of appetite, increased activity of "hepatic" transaminases.

Allergic reactions:itching, urticaria, skin rash.

From the nervous system:headache, dizziness, weakness, drowsiness, insomnia, hallucinations, confusion, paresthesia.

From the side of the organ of hearing and labyrinth disorders:hearing impairment.

Others:hyperthermia.

Overdose

Symptoms: increased dose-dependent side effects.

Treatment: symptomatic therapy.

Drug interactions

special instructions

No special training or diet is required when using Pirantel. In case of existing liver diseases, a doctor must be warned. It should be remembered that before using Pyrantel, like any other anthelmintic drug, you should thoroughly clean the room, wash children's toys, take a shower before and after sleep, and change your underwear. It is advisable to iron bed linen on the days of treatment and iron it with a hot iron for several days after taking the drug. To avoid re-infection, you must strictly follow the rules of hygiene: wash your hands, trim and clean your nails, avoid scratching in the crotch area, and change bedding and underwear daily. Thorough cleaning of living quarters and cleaning clothes for the destruction of helminth eggs serves to prevent reinfection. At the same time, treatment is recommended for all persons living together. The infection often does not show any symptoms. After completion of treatment, it is necessary to conduct a control study of feces for the presence of helminth eggs.

Influence on the ability to drive vehicles and work with mechanisms

During the period of treatment, one should refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Pregnancy and lactation

During pregnancy, use only if the intended benefit to the mother outweighs the potential risk to the fetus. If necessary, use of the drug during lactation should stop breastfeeding.

Pediatric use

The use of the drug in children under the age of 6 months is contraindicated.

Use the drug with caution in children aged 6 months to 6 years and weighing less than 10 kg.

For violations of liver function

The use of the drug in patients with hepatic impairment is contraindicated.

Terms of dispensing from pharmacies

The drug is available by prescription.

Storage conditions and periods

The drug should be stored in a place protected from light and out of reach of children at a temperature not exceeding 25 ° C. The shelf life is 3 years. Do not use the drug after the expiration date.

Composition and form of release
Pirantelpills:
1 tablet contains pyrantel 250 mg;
3 pcs. in a blister, 1 or 2 blisters in a cardboard box.

Pirantel suspension for oral administration:
5 ml of suspension contains 250 mg of pyrantel;
10 or 15 ml in dark glass bottles, 1 bottle in a cardboard box.

pharmachologic effect
Pirantel is an anthelmintic drug. Acts on the musculature of intestinal nematodes by depolarizing their neuromuscular junction and blocking the action of cholinesterase. Active against Enterobius vermicularis, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis. It acts on both sexually mature and immature individuals of both sexes, does not affect larvae in the migration stage.

Indications
Ascariasis; ankylostomiasis; necatorosis; enterobiasis.

Method of administration and dosage
Set individually depending on the age and body weight of the patient.
Children from 6 months to 2 years old - 125 mg (1/2 tab. Or 1/2 bed.)
children from 2 to 6 years old - 250 mg (1 tab. or 1 box)
children from 6 to 12 years old - 500 mg (2 tablets or 2 boxes)
children over 12 years old and adults weighing less than 75 kg - 750 mg (3 tablets or 3 boxes)
Adults weighing more than 75 kg - 1 g (4 tablets or 4 boxes)
1 scoop \u003d 5 ml.

With ascariasis and enterobiasis the drug is prescribed once in a dose of 10 mg / kg of body weight. In some cases, it is permissible to use the drug in a minimum dose of 5 mg / kg.
With ankylostomiasis prescribed in a dose of 10 mg / kg / day for 3 days.
For severe forms of necatorosis (massive invasions of Necator americanus) prescribed in a dose of 20 mg / kg / day for 2 days.
The drug is taken during or after a meal, the tablet should be chewed thoroughly.

Side effect
From the digestive system: possible nausea, vomiting, diarrhea, stomach pain; seldom -
increased activity of hepatic transaminases.
From the side of the central nervous system and peripheral nervous system: rarely - headache, dizziness, drowsiness, insomnia, weakness; in some cases - hearing impairment, hallucinations, confusion, paresthesia.
Others: skin rash, fever.

Contraindications
Hypersensitivity to pyrantel.

Pregnancy and lactation
Adequate and strictly controlled studies of the safety of the use of Pirantel during pregnancy and lactation (breastfeeding) have not been conducted. The use of the drug during these periods is possible only if the intended benefit to the mother outweighs the potential risk to the fetus or child.
IN experimental research the negative effect of Pirantel on the fetus has not been established.

special instructions
The drug should be prescribed with caution to patients with impaired liver function.
During the period of treatment of myasthenia gravis, Pirantel should not be prescribed.
The use of Pirantel does not require the simultaneous administration of laxatives.
With enterobiasis, simultaneous treatment of persons living together should be carried out. After completion of treatment, it is necessary to conduct a control study of feces for the presence of helminth eggs.
Pirantel is more effective at infection with Ancylostoma duodenale than the American hookworm (Necator americanus).
Use in pediatrics
The drug should be used with caution in children under 2 years old.
Influence on the ability to drive vehicles and use mechanisms
In some cases, while taking the drug, dizziness may occur, so you should be careful when performing work that requires the speed of psychomotor reactions.

Drug interactions
With simultaneous use with piperazine, the effect of Pirantel is weakened.
Pharmacokinetic interaction
With simultaneous use, Pirantel can increase the concentration of theophylline in blood plasma.

Storage conditions
The drug should be stored in a dry, dark place at a temperature not exceeding 25 ° C.

Shelf life tablets - 5 years;
Suspension shelf life - 3 years

Last updated description by manufacturer 27.07.2004

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Active substance:

ATX

Pharmacological group

Nosological classification (ICD-10)

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Composition and form of release

in dark glass vials of 15 ml (with a measuring cap); in a pack of cardboard 1 bottle.

Description of the dosage form

Suspension of light yellow color with a characteristic odor.

pharmachologic effect

pharmachologic effect - anthelmintic.

Blocks neuromuscular transmission in sensitive helminths.

Pharmacodynamics

Acts on helminths in the early phase of development and on mature forms, does not affect larvae in the stage of migration. Is active against Enterobius vermicularis, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis.

Pharmacokinetics

Practically not absorbed in the digestive tract. After oral administration in a single dose of 10 mg / kg body weight, C max is 0.005-0.13 μg / ml and is achieved within 1-3 hours. It is partially metabolized in the liver to N-methyl-1,3-propanediamine. It is excreted in feces (50% of the dose taken - unchanged) and in the urine (about 7% - unchanged and as a metabolite).

Indications of the drug Pirantel

Enterobiasis, ascariasis, ankylostomiasis, noncatorosis.

Contraindications

Hypersensitivity.

Application during pregnancy and lactation

Application during pregnancy and lactation is possible only under strict medical supervision.

Side effects

From the nervous system and sensory organs: rarely - headache, dizziness, drowsiness, insomnia, weakness; in some cases - hearing impairment, hallucinations, confusion, paresthesia.

From the digestive tract: nausea, vomiting, diarrhea, stomach pain; rarely - increased activity of hepatic transaminases.

Others: skin rash, fever.

Method of administration and dosage

Inside, during or after meals.

Enterobiasis, ascariasis and mixed infestations: once 10 mg / kg.

Ankylostomiasis: 10 mg / kg / day for 3 days.

Nekatoriasis: 20 mg / kg for 2 days (in severe forms).

Precautions

With enterobiasis, simultaneous treatment of persons living together should be carried out. After completion of treatment, it is necessary to conduct a control study of feces for worm eggs.

Storage conditions of the drug Pirantel

In a dark place at a temperature of 15-25 ° C.

Keep out of the reach of children.

Instructions for use

Active ingredients

Release form

Suspension

Composition

5 ml of suspension contains: Active ingredient: pyrantela pamoate 725 mg Excipients: methyl parahydroxybenzoate, propyl parahydroxybenzoate, saccharin, sodium chloride, sodium citrate, sucrose, citric acid, carmellose, sorbitol (70% solution), polysorbate 80 (tween 80), flavor chocolate, creamy flavor, purified water.

Pharmacological effect

Anthelmintic agent. It causes neuromuscular blockade of sensitive helminths. It is active against Enterobius vermicularis, Ancylostoma duodenale, Necator americanus and, to a lesser extent, Trichocephalus trichiurus. Acts on both sexually mature and immature individuals of both sexes.

Pharmacokinetics

Practically not absorbed from the gastrointestinal tract. After taking a single dose of 10 mg / kg, the plasma concentration is 0.005-0.13 μg / ml and is reached within 1-3 hours. It is metabolized partially in the liver to N-methyl-1,3-propanediamine. It is excreted unchanged through the intestines (about 93%), 7% is excreted by the kidneys unchanged or as a metabolite.

Indications

Ascariasis, ankylostomiasis, noncatorosis, trichocephalosis.

Contraindications

Pregnancy, hypersensitivity to pyrantel, myasthenia gravis (treatment period).

Application during pregnancy and lactation

Pirantel is contraindicated for use during pregnancy. If necessary, use during lactation should decide whether to stop breastfeeding.

Method of administration and dosage

For ascariasis and enterobiasis, it is used once at a dose of 10 mg / kg. When combining noncatorosis with ascariasis or other combined helminthic lesions, it is used for 3 consecutive days at a dose of 10 mg / kg / day or for 2 days - at a dose of 20 mg / kg / day.

Side effects

From the digestive system: nausea, vomiting, diarrhea, anorexia, increased activity of hepatic transaminases. From the central nervous system and peripheral nervous system: headache, hallucinations, confusion, paresthesia, dizziness, drowsiness or insomnia. Dermatological reactions: skin rash, urticaria. Others: hearing impairment, hyperthermia.

As part of drug in tablets contains an active ingredient pyrantel , as well as additional components: methyl parahydroxybenzoate, gelatin, acacia gum, starch, sodium carboxymethyl starch, talc, magnesium stearate, propyl parahydroxybenzoate, colloidal silicon dioxide.

Suspension Pirantel contains the active ingredient pyrantel, as well as additional components: sucrose, xanthan gum, sorbic acid, polysorbate 80, methyl parahydroxybenzoate, 70% solution, propyl parahydroxybenzoate, flavorings, purified water.

Release form

Produced suspension and pirantel tablets.

The suspension is a homogeneous yellow mass. Contained in 15 ml dark glass bottles.

Tablets are flat-cylindrical with a bevel, on the one hand - risk. The tablets are yellow. The polymer can contains 3 or 6 tablets.

pharmachologic effect

Pharmacokinetics and pharmacodynamics

After entering the digestive tract pyrantela pamoat very poorly absorbed. Plasma concentration is not significant and is 0.05–0.13 mg / ml, it is achieved within 1 to 3 hours. Partial occurs in the liver, the main one is N-methyl-1,3-propanediamine.

The main part of the active substance is excreted from the body in the feces, approximately 7% in the urine.

Indications for use

Suspension and Pirantel tablets from worms are prescribed for the following diseases:

• non-kotorosis.

Contraindications

There are such contraindications for the use of the drug:

• high level of sensitivity to pirantelu and any other components of the product;
• liver failure ;
• child's age up to 6 months.

Side effects

In the course of treatment, the following side effects may appear:

• nervous system : , , ;
• digestive system : vomiting, recurrent abdominal cramps, anorexia , tenesmus;
• skin and subcutaneous tissue :, rash;
• hepatobiliary system : increased hepatic levels;
• other manifestations : feeling of weakness, increased fatigue.

Application instruction of Pirantel (Way and dosage)

The tool is used according to the testimony of a doctor.

Suspension Pirantel, instructions for use

Suspension for children is used according to indications, it must be shaken before taking it. Patients with ascariasis and enterobiasis are prescribed an average dose of 10-12 mg per 1 kg of body weight at one time. Children after 6 months should receive syrup at a dose of 2.5 ml per 10 kg of body weight at one time. Adult patients (up to 75 kg) receive 15 ml in 1 dose. If a person's weight exceeds 75 kg, you need to drink 20 ml of the product at one time.

To improve the effectiveness in the treatment of enterobiasis, you should very carefully adhere to all the rules of personal hygiene. It is recommended to carry out another course of therapy after three weeks.

For patients with ankylostomiasis in endemic areas or with severe invasion, the drug is prescribed based on a dosage of 20 mg per 1 kg of body weight for 2 or 3 doses, the treatment lasts 2-3 days.

The dosage per day is calculated as follows:

• children after 6 months receive 5 ml of syrup per 10 kg of weight;
• with a weight of up to 75 kg - 30 ml of syrup per day;
• with a weight of 75 kg - 40 ml of syrup per day.

Subject to mild invasion Ankylostoma duodenale sometimes it is enough to take a dose of 10 mg per 1 kg once.

Pirantel tablets, instructions for use

For adults, Pirantel tablets are usually prescribed. It should be taken before or during food intake. The tablet is chewed and washed down with plenty of liquid.

How to take Pirantel for children depends on their body weight and age:

• at the age of 2-6 years, 250 mg of the drug is indicated;
• at the age of 6-12 years - 500 mg;
• children after 12 years of age and adult patients weighing up to 75 kg - 750 mg;
• adults weighing more than 75 kg - 1000 mg.

If only human nematode infection is noted, Pirantel 5 mg per 1 kg of body weight should be taken in one pr.

For patients with enterobiasis and ascariasis, as well as with mixed invasions, the dose, which is intended for the entire course, is used once (10 mg per 1 kg).

Patients with ankylostomiasis are shown to take the same dose for three days.

In the case of massive invasions of Necator americanus, a dose of 20 mg / kg is indicated for two days

For more information about how many days to take the drug, how to drink tablets and suspensions for adults and children for treatment, as well as for prophylaxis for adults and children, you should ask your doctor.

Overdose

In case of an overdose of the drug, the patient may experience the following negative manifestations: nausea, vomiting, anorexia ... But it should be borne in mind that pyrantel is poorly absorbed in the body, which is why the symptoms appear very rarely, even with a significant overdose. If there is such a need, gastric lavage is prescribed, there is no specific. It is important to control the functions of blood vessels, heart, respiratory system.

Interaction

Do not prescribe Pirantel treatment at the same time , since in this case there may be a potentiation of the toxic effect of Levamisole, the level of .

It is impossible to use tablets and suspension at the same time as Piperazine, since this drug is an antagonist of the antihelminthic effect of Pirantel.

Terms of sale

You can buy Pirantel by prescription.

Storage conditions

During storage, protect from light and high temperatures. Once the bottle has been opened, it can be stored for up to 4 weeks.

Shelf life

Pirantel can be stored for 3 years

special instructions

The remedy is carefully prescribed to people who have liver dysfunctions. During therapy, one should not refrain from eating or taking laxatives. How quickly the drug works does not depend on this.

The tool is prescribed for simultaneous admission to all members of the family who live together. You should consider how to give the child the suspension or tablets, and follow the instructions. After completion of the study, the patient's feces are examined.

To avoid re-infection, it is important to follow good hygiene practices.

Sometimes in the course of treatment there may be fromweakness, dizziness ... This should be taken into account when driving or working with precision mechanisms.

Do not prescribe a remedy for people who are undergoing treatment myasthenia gravis .

How long the drug works depends on the diagnosis and individual characteristics of the course of the disease.

Which is better: Decaris or Pirantel?

Dekaris - an antihelminthic agent that has a similar effect. The drug Dekaris has more contraindications, the side effects are almost the same as when using Pirantel. It is believed that Pirantel is preferred for the treatment of children.

Which is better: Vermox or Pirantel?

Is a broad-spectrum drug. It is especially effective for enterobiasis and trichocephalosis. Which of the two drugs is preferred should be determined on an individual basis.

Nemozole or Pirantel: which is better?

Pirantel for children

Reviews about Pirantel for children that parents leave are mostly positive. However, it should be borne in mind that the instructions for the suspension for children provide that the drug is not prescribed for children under 3 years of age. It is important to strictly follow the instructions on how to take the suspension. The dosage for children must be carefully observed.

With alcohol

Pirantel in suspension and tablets should not be combined with alcoholic beverages.

During pregnancy and lactation

When you can use this medication exclusively for strict indications, carefully balancing the benefits for the expectant mother and harm to the fetus. During the drug is not used.

Reviews about Pirantel

Pirantel's price where to buy

The price of a 15 ml Pirantel suspension is, on average, 60 rubles. The cost may be slightly lower or higher. The price of Pirantel tablets depends on the packaging and manufacturer. On average, buy a pack of 3 tablets. you can at a price of 20 to 40 rubles. How much this drug costs in pharmacies should be asked directly at the points of sale.

• Online pharmacies in RussiaRussia
• Online pharmacies of UkraineUkraine
• Internet pharmacies in KazakhstanKazakhstan

ZdravCity

Ozone OOO

Pirantel tablets 250mg 3 pcs.Polpharma

Medana Pharma Terpol Group Joint Stock Company

Pirantel suspension for internal approx. 250mg / 5ml 15mlOzone OOO