Antiulcer drug Famotidine - instructions for use. What does Famotidine help with? Instructions, prices and real reviews Famotidine application

Famotidine is an antiulcer drug. It lowers the production of hydrochloric acid and reduces the performance of pepsin. The drug is more often prescribed for use in patients with diseases of the gastrointestinal tract: gastric ulcer or duodenal ulcer, erosive gastritis. After taking the drug, the effect is noticeable within an hour and lasts about 2 days.

What's in

Famotidine tablets contain an active substance in a dose of 20 or 40 mg, as well as additional components. Tablets with a dosage of 20 mg are yellow, 40 mg are pink. The shape is biconcave. One package contains 20 tablets.

Pharmacokinetics

After application, rapid absorption from the stomach occurs. It binds to blood proteins by only 23%. The active substance is able to penetrate into the mother's milk and through the blood-brain barrier. Most of the metabolism takes place in the liver. It is excreted mainly in the kidneys unchanged in 25–38% of cases.

Who is shown

Famotidine indications for use in various diseases of the gastrointestinal tract. These include: dyspepsia;

• mastocidosis;
• prevention of recurrences in case of stomach and intestinal ulcers, as well as in the acute period;
• helps relieve symptoms of reflux esophagitis;
• after surgery as prevention of bleeding;
• in order to prevent aspiration of gastric juice during operations;
• stress ulcers;
• zollinger-Ellison syndrome;
• erosive gastritis and gastroduodenitis.

When you can't take the drug

Famotidine tablets have contraindications in several situations:

• pregnancy and lactation;
• age up to 3 years (for tablets);
• allergic reactions to one of the components of the drug or an active substance.

Famotidine is carefully prescribed for the elderly and with renal and hepatic insufficiency.

How to apply

The dosage is selected by the doctor in accordance with the age and severity of the disease. The tablets are not chewed and washed down with a large amount of still liquid. Basically, for ulcers of the stomach and intestines, 0.04 g is prescribed once a day, this dosage can be divided into 2 doses. After 6-8 weeks, the dose of the drug is reduced to 0.02 g per day.

For preventive purposes, Famotidine should be taken only 1 time, preferably at night.

Reflux esophagitis requires a dose of 0.02 g 4 times a day.

When intervening in surgery, the drug is prescribed once before the operation or 12 hours before it in an amount of not more than 40 mg.

With kidney disease, the dosage is reduced by 2 times.

When prescribing a drug with antacids, an interval of 2 hours should be observed. In rare cases, the daily dosage may be increased to 148 mg.

Can i take during pregnancy?

Famotidine tablets have contraindications for use during pregnancy and lactation.

What can cause

Quite often, after taking Famotidine, sweating, cramping abdominal pains, bloody discharge from the vagina, nausea, and sometimes vomiting are observed. From the side of the central nervous system, severe headache, insomnia, changes in the cornea, depression, fatigue, lethargy, blurred vision, cataracts are possible. On the part of the heart and blood vessels, in extremely rare cases, pulmonary embolism is possible, as well as venous thrombosis, a violation in the work of the heart muscle.

Taking Famotidine is often accompanied by an allergic reaction: rash, Quincke's edema, alopecia, anaphylactic reactions, dry skin. On the part of the digestive system, constipation or diarrhea, anorexia, and lack of appetite often appear. With the use of the drug, there may be an increase in weight. Rarely there is shortness of breath at rest or with little physical exertion, rare cases of calcium salt deposition in the joints. There is a high risk of developing cancer of the uterus and appendages, hyperplasia or polycystic disease. On the part of blood parameters, there may be leukopenia, a decrease in leukocytes in the blood, agranulocytosis, thrombopenia.

What if you exceed the dose

With an increase in the dose of Famotidine tablets, the phenomena of dizziness, nausea and headache are observed. Perhaps the occurrence of uterine bleeding and hot flashes, due to the enhancement of the estrogenic effect of the created active substance of the drug. There is no antidote. Only symptomatic treatment is carried out, and for the first time, hours of gastric lavage. In extreme cases, it is possible the appearance of seizures and ventricular arrhythmias.

How does it interact with other drugs

Famotidine increases the absorption of Amoxicillin. Do not use Famotidine with Lidocaine, Diazepam, Theophylline and anticoagulants. A case of application with Nifedipine is described. They cannot be taken at the same time, this leads to a decrease in cardiac output.

special instructions

Patients with impaired renal and liver function should be used with caution. The dosage for them is selected by the doctor individually. Before treatment, an examination is prescribed for the presence of tumor processes in the gastrointestinal tract. Does not affect the ability to drive and does not reduce the responsiveness.

Appointment for children

Famotidine instruction says that pills can be used in children only from the age of 14. In rare cases, pediatricians are prescribed under strict supervision to children over 7 years old.

What does the drug help from in children?

More often, Famotidine is prescribed for children with gastric ulcer and 12 duodenal ulcer, less often with gastroduodenitis, ulcerative gastritis and functional dyspepsia. For children, Famotidine is prescribed at 2 mg per kilogram of weight, but not more than 0.04 g. It should be taken at night with plenty of water.

Drug analogues

There are a huge number of Famotidine analogues. These include:

• Gastrosidine;
• Ulfamide;
• Pepsidin;
• Gasterogen;
• Famosan;
• Famopsin;
• Famotel;
• Ranisan;
• Ranitidine;
• Rantak;
• Famozole.

These drugs also contain the active ingredient famotidine and are available in tablets. Each of the drugs has its own pros and cons, and the analog does not always help. It is possible to replace Famotidine with an analogue only after consulting a doctor.

The cost

Famotidine costs about 50-70 rubles for 20 tablets.

Storage conditions and shelf life

Famotidine is stored away from children and sunlight at a temperature not exceeding 25 degrees for 2 years.

Dispensing from pharmacies

It is dispensed only by prescription.

Famotidine is a drug used in gastrointestinal diseases. Let's consider the main indications for its use, possible side effects, dosage and contraindications.

The drug is prescribed for patients with gastrointestinal lesions, with peptic ulcer of the duodenum and stomach. Tablets belong to the blockers of H2-histamine receptors. The medication suppresses the secretion of hydrochloric acid, like its own. This is due to the stimulation of gastrin, histamine, and acetylcholine. This reduces the activity of enzymes that break down proteins - pepsin. The therapeutic effect occurs within 60 minutes after a single dose and lasts from 12-14 hours.

Before using the medication, it must be remembered that it can hide the symptoms caused by gastric carcinoma. Therefore, before starting therapy, you must exclude any malignant neoplasms. Refusal to accept should be gradual, since there is a risk of developing rebound syndrome due to abrupt withdrawal. With prolonged therapy of patients with a weakened immune system and nervous disorders, bacterial damage to the stomach and further spread of infection are possible.

Blockers of H2-histamine receptors are allowed to be taken 2-3 hours after drugs such as: Itraconazole, Ketoconazole, Histamine, Pentagastrin. This will avoid a decrease in their absorption and influence on the acid-forming function of the stomach. The active ingredients suppress the skin reaction when using Histamine, that is, they provoke false negative results. Therefore, before performing skin tests for diagnostic purposes, it is necessary to stop taking H2-histamine receptors. In addition, during therapy, you should avoid eating foods and drinks that irritate the gastric mucosa.

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ATX code

A02BA03 Famotidine

Active ingredients

Famotidine

Pharmacological group

H2 antihistamines

pharmachologic effect

Antiulcer drugs

Indications for use of Famotidine

H2-histamine receptors are prescribed for patients with various diseases of the gastrointestinal tract. Consider the main indications for the use of Famotidine:

• Stomach ulcer
• Duodenal ulcer
• Inflammation of the esophagus (caused by the throwing of stomach contents into the organ)
• Zollinger Ellison Syndrome
• Systemic mastocytosis
• Erosive gastroduodenitis
• Functional dyspepsia (similar to increased secretory function)
• Reflux esophagitis
• Prevention of recurrent bleeding in the postoperative period
• Treatment and prevention of symptomatic and stressful gastrointestinal ulcers
• Prevention of aspiration pneumonitis
• Polyendocrine adenomatosis
• Prevention of Mendelssohn's syndrome (aspiration of gastric juice in patients undergoing surgery with general anesthesia)
• Dyspepsia with epigastric or chest pain at night or associated with food intake
• Prevention of relapses associated with long-term use of non-steroidal anti-inflammatory drugs

Release form

Famotidine has a tablet form of release. The capsules are available in the following dosage:

• 20 mg (0.02 g) - 20 pieces in a package
• 40 mg (0.04 g) - 20 pieces in each package

Basic physical and chemical properties: tablets are white, round, convex, coated, odorless.

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Famotidine "lx"

One of the varieties of the blocker of H2-histamine receptors - Famotidine "lx". International and chemical name of the medicinal product: famotidine; N2- (aminosulfonyl) -3 - [[thiazol-4-yl] methyl] thio] propanamidine. The medicine has a tablet form, coated with an enteric coating, 0.02 g of active ingredient.

• Pharmacotherapeutic group - medicines that affect the metabolism and the digestive system. It is an antagonist of H2-receptors of the 3rd generation. Suppresses and reduces the production of hydrochloric acid and the activity of pepsin. After oral administration, it is rapidly absorbed from the gastrointestinal tract, but not completely. Bioavailability is 45% and changes in the presence of food, the half-life is 3-5 hours.
• It is used for the treatment and prevention of exacerbations of duodenal and stomach ulcers, Zollinger-Ellison syndrome. The dosage is selected individually for each patient. As a rule, 40 mg is prescribed per day, before bedtime, the duration of treatment is 1-2 months. When a therapeutic effect is achieved, a maintenance application of 20 mg per day is indicated.
• Side effects are manifested in the form of headaches, dizziness, nausea, diarrhea or constipation, skin-allergic reactions and abnormalities in the liver. The tablets are not used in case of hypersensitivity to their components, during pregnancy and lactation, and for patients under 14 years of age. Overdose manifests itself as an increase in side effects.

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Famotidine 10 medic

For the treatment of peptic ulcer of the gastrointestinal tract, many drugs are used. But special attention should be paid to Famotidine 10 medic. Its chemical and international name is famotidin; -4 thiazolyl] methyl] thio] propylidene] sulfamide. One tablet contains 10 mg of active ingredient. Included in the pharmacotherapeutic group of agents for the treatment and prevention of gastroesophageal reflux disease and peptic ulcer.

• The drug suppresses the secretion of hydrochloric acid (basal and stimulated by gastrin, histamine and acetylcholine) and weakly inhibits the oxidase system of cytochrome P450 in the liver. Single use effectively suppresses gastric acid secretion and enhances the protective mechanisms of the gastrointestinal mucosa. This is due to an increase in the formation of gastric mucus, glycoproteins and stimulation of the secretion of bicarbonate, which accelerates the healing process of mucosal lesions.
• After oral administration, it is rapidly and completely absorbed. The maximum concentration in blood plasma is observed after 2-2.5 hours. Bioavailability at the level of 20-60%, about 10-30% of active components binds to albumin in blood plasma. 20-35% is excreted unchanged in the urine, 30-35% is metabolized in the liver. The half-life takes 3-4 hours, but in patients with creatinine clearance it can be up to 20 hours.
• It is used for the symptomatic treatment and prevention of non-ulcer dyskinesia, which is caused by hyperacidity of gastric juice, due to unhealthy diet or drinks, alcohol and tobacco abuse. Tablets are taken 10 mg 2 times a day one hour before meals. With daily use, the duration of therapy should not exceed 14 days.
• Side effects are manifested from all organs and systems, but most often they are: headaches, dizziness, disturbances in the digestive tract, increased fatigue, arrhythmia, leukopenia, skin allergic reactions, muscle pain, dry skin.
• It is not used in case of hypersensitivity to the active substance, during pregnancy and lactation, for the treatment of minor patients. In case of an overdose, a decrease in blood pressure, collapse, tremor of the limbs, vomiting, tachycardia is possible. Hemodialysis is effective, symptomatic therapy and gastric lavage are performed.

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Famotidine 20-cl

Means for the treatment of gastroesophageal reflux disease and peptic ulcers, allow to normalize the work of the gastrointestinal tract and minimize the negative impact on the body. Famotidine 20-cl is included in the category of such drugs.

• It is used to eliminate ulcerative lesions of the duodenum and stomach. Effective for gastric bleeding, reflux esophagitis, that is, conditions that require inhibition of gastric acid secretion. It is used with increased secretion of gastric juice - Zollinger-Ellison syndrome and as a prophylaxis for erosive and ulcerative lesions of the gastrointestinal tract while taking NSAIDs.
• The active ingredient is famotidine, one tablet contains 20 mg. The drug suppresses secretion by reducing the content of the food enzyme pepsin and hydrochloric acid in the stomach. Thanks to this, the gastrointestinal tract is protected from the effects of aggressive factors that provoke the progression of the ulcer. The dosage and duration of therapy depend on the individual characteristics of the patient's body and the severity of the disease.
• After ingestion, it quickly dissolves in the gastrointestinal tract. The maximum concentration in blood plasma is reached after 1-4 hours, bioavailability at 43%. Food intake does not affect the absorption and distribution process.
• As a rule, Famotidine is well tolerated, but side effects are possible. Most often these are headaches, diarrhea, muscle and joint pain, constipation, nausea, flatulence, skin allergic reactions. It is not used during pregnancy and lactation, in patients under 14 years of age and in case of hypersensitivity to active ingredients.

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Famotidine 40-cl

Drugs that suppress the secretion of hydrochloric acid and food enzymes are used to treat ulcers of the gastrointestinal tract. Famotidine 40-cl refers to them, as it protects the stomach and duodenum from aggressive factors that cause pathological ailments.

• The medicine is available in tablet form. Basic physical and chemical properties: tablets are enteric coated, round with a convex surface. One capsule contains 40 mg of the active ingredient. After ingestion, it is rapidly absorbed, the maximum concentration in the blood serum occurs in 1-4 hours.
• Food intake does not affect absorption and bioavailability. Distributed into the tissues of the kidneys, liver, digestive tract, submandibular and pancreas. The binding to blood proteins is 20%, the half-life is 3 hours, but the pharmacological effects last longer.
• The medication is prescribed for the treatment of ulcerative lesions of the gastrointestinal tract, with violations of the secretion of gastric juice, as a prophylaxis of erosive and ulcerative lesions of the gastrointestinal tract caused by the use of non-steroidal anti-inflammatory drugs. The dosage and route of administration depend on the severity of the disease. Food intake does not affect the pharmacokinetic features of the drug.
• Side effects cause headaches and dizziness, increased fatigue, dry mouth, gastrointestinal disorders. Tablets are not used for hypersensitivity to active ingredients, pregnant women and patients under 14 years of age. Overdose symptoms are expressed as increased side effects.
• Before starting therapy, it is necessary to make sure that there are no malignant lesions of the stomach and duodenum. This is due to the fact that the medication can hide the symptomatic picture in gastric cancer. Used with extreme caution in patients with impaired liver and kidney function.

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Famotidine Darnitsa

Blockers of H2-histamine receptors of the stomach walls, which reduce the secretion of gastric juice, are used to treat ulcers of the digestive system. Famotidine-Darnitsa reduces the amount and concentration of gastric juice and pepsin. The tablets are effective for Zollinger-Ellison syndrome, reflux esophagitis, gastric and duodenal ulcers.

• Famotidine is available in dosages of 20 and 40 mg. It is taken at night, as it reduces the basal and nocturnal secretion of gastric juice. Does not affect gastrin levels before or after meals, gastric emptying and pancreatic secretory function, portal blood flow and hepatic circulation.
• After oral administration, it is rapidly and completely absorbed. Bioavailability at the level of 40% and does not depend on the contents of the stomach. The maximum concentration in blood plasma is after 1-3 hours, repeated administration causes the effect of cumulation. Plasma protein binding is 15-20%, half-life is up to 20 hours. It is metabolized in the liver, excreted by the kidneys.
• In the treatment of benign lesions of the stomach and duodenum, take 40 mg at a time or 20 mg in the morning and evening, for 4-8 weeks. For prophylactic purposes - 20 mg once a day for 1-4 weeks. To eliminate chronic gastritis (with increased acid-forming function), 40 mg per day is prescribed, the course is 2-4 weeks. In Zollinger-Ellison syndrome, the recommended dosage is 20 mg 4 times a day, the duration of the course is individual.
• Side effects are manifested from all organs and systems of the body, but most often they are: arrhythmia, nausea, vomiting, pain in the peritoneum, diarrhea or constipation, allergic skin reactions, muscle and joint pain. In rare cases, bronchospasm, abnormalities in the functioning of the liver and kidneys occur.
• It is contraindicated to use in case of hypersensitivity to the components of the drug, as well as during pregnancy, lactation and in pediatric patients. In case of overdose, there is an increase in side effects. Most often it is a decrease in blood pressure, tachycardia, vomiting and tremors. Supportive and symptomatic therapy is used to eliminate adverse symptoms.

Famotidine-health

Ukrainian pharmaceutical company "Zdorovye" and LLC "Pharmex Group" are engaged in the production of various drugs. Famotidine-health is produced by this enterprise and is a selective antagonist of H2 receptors of the third generation. The active ingredient is famotidine, one tablet contains 20 mg. The medication is used to treat gastroesophageal reflux disease and peptic ulcers.

• After ingestion, it is quickly and completely absorbed, food intake does not affect this process. The maximum concentration in blood plasma - after 1-3 hours, binding to blood proteins - 15-20%, bioavailability - 40-45%. It is metabolized in the liver, forming an inactive sulfoxide metabolite, excreted by the kidneys. Penetrates through the placental barrier, into cerebrospinal fluid and breast milk.
• The mechanism of action is due to the inhibition of H2 histamine receptors in the stomach wall. This reduces the secretion and volume of gastric juice, and the activity of pepsin. Strengthens the defense mechanisms of the gastric mucosa by increasing the secretion of gastric mucus. This speeds up the healing process of the existing damage.
• Contraindicated in case of intolerance to histamine H2 receptor antagonists and any other components of the drug. Used with caution in elderly patients and patients taking non-steroidal anti-inflammatory drugs. Not prescribed for pregnant women, during lactation and for patients under 14 years of age. The dosage and duration of therapy depend on the severity of the disease and the age of the patient.
• In case of an overdose, vomiting, motor excitement, lowering blood pressure, increased heart rate, tremor appear. Treatments include symptomatic therapy, gastric lavage, or induction of vomiting. Hemodialysis is effective.
• Side effects most often cause disturbances in the digestive tract - vomiting, nausea, hepatitis, flatulence, diarrhea, constipation, dry mouth. Undesirable symptoms from the hematopoietic system are possible - these are leukopenia, thrombocytopenia. Most often, headaches, dizziness, cramps, muscle weakness, depression, anxiety and anxiety, confusion, and allergic reactions occur.

Pharmacodynamics

Famotidine belongs to the pharmacological category of drugs-blockers of H2-histamine receptors. Consider the main characteristics of the pharmacodynamics of this drug:

• Suppresses the production of HCl, both basal and stimulated by gastrin, histamine, acetylcholine. Reduces the activity of pepsin and increases the pH level.
• By increasing the volume of gastric mucus and glycoproteins, it enhances the protection of the gastric mucosa and the level of stimulation of endogenous Pg synthesis and stimulation of bicarbonate secretion. Accelerates the healing process of injuries, effectively stops gastrointestinal bleeding.
• The therapeutic effect occurs 60 minutes after ingestion and reaches its peak within 3 hours. The therapeutic effect is maintained from 12-24 hours. The active substance weakly suppresses the oxidase system of cytochrome P450 in the liver. When administered intravenously, the maximum result is observed after 30 minutes. Taking a tablet of 10 or 20 mg suppresses secretion for 10-12 hours.

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Pharmacokinetics

The effectiveness of Famotidine is indicated not only by its composition, but also by the processes that occur with it after ingestion. Pharmacokinetics allows you to learn about the absorption, distribution, metabolism and excretion of the agent used.

• After oral administration, it is rapidly and completely absorbed from the gastrointestinal tract. The maximum concentration in blood plasma is reached after 1-4 hours.
• The active ingredient enters the cerebrospinal fluid, through the placental barrier and is excreted in breast milk. The binding to blood plasma proteins is 15-20%.
• About 35% of the active ingredient is metabolized in the liver, forming S-oxide.
• The elimination process takes place through the kidneys. About 25-40% is excreted unchanged in the urine. The half-life takes 2-4 hours, and in patients with impaired liver and kidney function, 10-12 hours.

Famotidine use during pregnancy

With special difficulties in the treatment of diseases of the gastrointestinal tract, in particular peptic ulcer of the duodenum and stomach, women face during gestation. The use of Famotidine during pregnancy is contraindicated. This is due to the fact that the drug belongs to the blockers of H2-histamine receptors. Drugs of this pharmacological group penetrate into all biological fluids, that is, through the placental barrier and even into breast milk.

This can negatively affect the development of the fetus and cause a number of negative symptoms in the mother. The medicine is not used during lactation. If the use of a medication is mandatory, then the expectant mother should understand all the risks. But, as a rule, safer drugs with minimal side effects are selected for pregnant women.

Contraindications

Each drug has certain restrictions on its use. Consider the main contraindications to the use of Famotidine:

• Individual intolerance to active ingredients
• Hypersensitivity to histamine H2 receptor blockers
• Pregnancy
• Lactation
• Patient age up to 16 years

With extreme caution, the medication is used by elderly patients and with impaired renal and liver function.

Famotidine is an anti-ulcer medication that is used to reduce gastric acid secretion. Famotidine is able to significantly block H2-histamine receptors located in the mucosa, as well as suppress the activity of the gastric enzyme pepsin ( breaks down proteins to amino acids). This drug belongs to the third generation histamine receptor blockers ( antihistamines ).

After oral administration of famotidine tablets, the effect occurs in about 60 minutes, and the maximum therapeutic effect is observed after 2 to 3 hours. The duration of the antisecretory action of famotidine is, on average, 12-14 hours.

Types of medication, commercial names of analogues

Famotidine is available in the form of tablets, which can be film-coated or film-coated. It should be mentioned that this antiulcer medication has the following analogues - Kvamatel, Ulfamid, Gastrosidin, Famosan, Famotel and others.

Famotidine manufacturers

Company manufacturer	Commercial name of the drug	A country	Release form	Dosage
Obolenskoe	Famotidine	Russia	Film-coated tablets.	It is recommended to drink the tablets with a large glass of liquid ( not less than 200 ml) without chewing them. The dosage and duration of treatment with famotidine is selected based on the type of disease. With an exacerbation of duodenal ulcer or stomach ulcer, it is prescribed to take 20 milligrams twice a day, or 40 milligrams 1 time a day at night. It is sometimes advisable to increase the daily dosage from 80 to 160 milligrams. The duration of treatment is one to two months. With reflux esophagitis ( throwing stomach contents into the esophagus) is prescribed 20 - 40 mg twice a day. The course of treatment can last from 1 to 3 months. It should be noted that the daily dosage should be reduced to 20 milligrams in case of impaired renal function.
Alkaloid	Famotidine	Macedonia
Biocom	Famotidine	Russia
Ozone	Famotidine	Russia
Hemofarm	Famotidine	Russia	Film-coated tablets.
Pharmsynthesis	Famotidine	Russia
Pharmstandard-leksredstva	Famotidine	Russia
Makiz Pharma	Famotidine STADA	Russia
Synthesis	Famotidine-AKOS	Russia
Akrikhin	Famotidine-ACRI	Russia

The mechanism of the therapeutic action of the drug

Famotidine is an antisecretory drug that blocks histamine H2 receptors. Interacting with these receptors, famotidine causes a significant decrease in the production of hydrochloric acid and gastric enzyme pepsin ( antisecretory action).

When taken orally, famotidine tablets are quickly absorbed ( absorbed) in the gastrointestinal tract. The antisecretory effect of the drug is observed after an hour and a half, and after 2 - 3 hours its maximum concentration is observed in the bloodstream. Famotidine is metabolized in the liver tissue, and excreted through the kidneys ( 30 - 40% unchanged). It should be noted that the daily dosage should be reduced to 20 milligrams in case of impaired renal function.

Famotidine can cross the placenta into the bloodstream of the fetus and into breast milk.

What pathologies is it prescribed for?

Famotidine is used as an antisecretory drug for the treatment and prevention of gastric ulcer and duodenal ulcer.

Famotidine use

Indication for use	Mechanism of action	Dosage
Exacerbation of duodenal and stomach ulcers	It is able to block histamine receptors located in the stomach. Reduces the synthesis of hydrochloric acid by stomach cells. Reduces the production of pepsin to some extent.	The tablets are taken regardless of food intake, washed down with plenty of liquid. Also, the tablets should not be chewed. Inside, 20 milligrams twice a day or 40 milligrams once a day just before bedtime. The duration of treatment is usually 4 to 8 weeks.
Symptomatic ulcers (ulcers that occur against the background of endocrine, stress or other factors)
Erosive gastroduodenitis (erosion of the mucous membrane of the stomach and duodenum)
Dyspepsia(disruption of the stomach) against the background of increased production of hydrochloric acid		At a dosage of 20 milligrams once or twice a day. The course of treatment is selected by a gastroenterologist.
Gastroesophageal disease (throwing gastric contents into the esophagus)		A single dose is 20 - 40 mg. The tablets are taken twice a day for 6 to 12 weeks.
Zollinger-Ellison syndrome (the release of a large amount of the hormone gastrin and hydrochloric acid against the background of a pancreatic tumor)		The starting dosage is most often 20 milligrams. Sometimes your doctor may increase your dosage to 160 milligrams.
Relapse prevention(reoccurrence) duodenal and stomach ulcers		Take 20 milligrams of the drug once at night.
Prevention of aspiration of gastric juice during anesthesia (ingestion of stomach contents into the respiratory system)		40 milligrams in the evening before surgery, or the same dosage in the morning before surgery.
Prevention of upper digestive system bleeding		Assign 20 milligrams twice a day. The course of treatment lasts, on average, 20 to 30 days.

How to use the medication?

Famotidine tablets can be used both on an empty stomach and after meals, since food intake practically does not affect the absorption of the drug in the mucous membrane of the gastrointestinal tract. It is not recommended to chew famotidine tablets. You need to drink pills with plenty of liquid.

For the treatment of exacerbation of duodenal or stomach ulcers, as well as with erosive gastroduodenitis, 20 milligrams of famotidine is prescribed twice a day or 40 milligrams once a day at night. Sometimes your doctor may increase the daily dosage to 80 to 160 milligrams. The duration of treatment is 1 - 2 months. For the prevention of peptic ulcer disease, the doctor may prescribe a single dose of famotidine at a dosage of 20 milligrams ( at night).

In the treatment of dyspepsia ( violation of gastric activity) against the background of the acidity of the stomach, as a rule, it is prescribed to take 20 milligrams of the drug once or twice a day. The duration of treatment is selected individually.

Acute pancreatitisIs an inflammation of the pancreas. With pancreatitis, pancreatic enzymes are not released into the lumen of the duodenum, but are activated in the gland itself. In the future, this leads to the destruction of the pancreas' own tissues, as a result of which enzymes and toxins are released into the bloodstream, which can penetrate into various organs and tissues and seriously damage them. Acute pancreatitis can present with severe abdominal pain, nausea, bloating, and vomiting that does not provide relief. Often, against the background of acute pancreatitis, dehydration of the body appears ( violation of water-salt balance).

Violations of the genitourinary apparatus

In quite rare cases, famotidine can affect the genitourinary system and lead to serious disorders. These side effects appear against the background of long-term use of large doses of famotidine.

Famotidine can cause the following side effects:

• decreased potency and libido;
• gynecomastia;
• hyperprolactinemia;

Decreased potency and libidooccurs due to the fact that large doses of famotidine can affect the exchange of male sex hormones ( mainly on testosterone). Testosterone levels directly affect libido ( sex drive) and potency. With its decrease, potency also decreases.

Gynecomastiais a pathology that occurs only in men. Gynecomastia is characterized by an increase in mammary glands due to an increase in its glandular and adipose tissue. This violation occurs as a result of a decrease in the level of male sex hormones.

Hyperprolactinemiais a condition of the body in which the level of the hormone prolactin in the blood is increased. This hormone mainly acts on the mammary glands and promotes the milk maturation process. Also, prolactin enhances the development and growth of the mammary glands. It should be noted that against the background of taking famotidine, this pathology appears extremely rarely.

Amenorrheacharacterized by the absence of menstruation for more than six months. It should be noted that amenorrhea is not a disease, but only serves as a symptom of any disorder in the body. With long-term use of famotidine, amenorrhea may occur due to hyperprolactinemia.

Violations of the hematopoietic system

In rare cases, famotidine can adversely affect the hematopoietic system and cause a decrease in the number of blood cells ( blood cells). This is due to the fact that interacting with blood cells, famotidine in rare cases is able to change its molecular configuration and becomes an allergen. As a result, antibodies are produced to it ( special molecules of the immune system), which bind with it and with blood cells and start complex processes. As a result, this leads to the destruction of a certain number of blood cells. Also, in very rare cases, famotidine can inhibit the process of hematopoiesis by acting on the bone marrow.

In rare cases, famotidine can cause the following side effects from the hematopoietic system:

• leukopenia;
• neutropenia;
• pancytopenia.

Hemolytic anemiacharacterized by damage to the erythrocyte membrane ( red blood cells), which leads to their destruction. As a result, serum iron and unbound bilirubin are released from erythrocytes, which has a toxic effect on body tissues. It is due to bilirubin that the skin and mucous membranes acquire a yellow tint ( jaundice).

LeukopeniaIs a decrease in the number of white blood cells in the blood ( leukocytes). With drug leukopenia, there is a rapid decrease in the immune status, as a result of which a person becomes susceptible to various infectious diseases. Leukopenia is characterized by symptoms such as headache, fever, chills, an increase in the number of heart contractions ( tachycardia), as well as general depletion of the body.

Thrombocytopeniamanifested by a decrease in the total number of platelets in the blood, or platelets. These blood cells are necessary for the normal coagulation process ( blood clotting). The decrease in platelets leads to bleeding of the gums. Very often, against the background of thrombocytopenia, spontaneous bleeding from the nose occurs. With thrombocytopenia, bleeding can occur in various tissues and organs ( sometimes in the brain).

Neutropeniais a special case of leukopenia and is characterized by a decrease in the number of neutrophils ( one of the subtypes of white blood cells) in blood. It is neutrophils that are responsible for immunity and protect the body from fungal and bacterial infections. Neutropenia generally presents with the same symptoms as leukopenia.

Pancytopeniais a serious pathology in which there is a decrease in all blood cells ( leukocytes, erythrocytes and platelets). Pancytopenia is a direct consequence of bone marrow suppression. The severity of the symptoms of pancytopenia depends on the duration of this condition, as well as on the severity of leukopenia, thrombocytopenia and anemia.

Cardiovascular disorders

Famotidine is to some extent capable of acting on blood vessels and the heart. Most often this is manifested by a slight decrease in blood pressure ( hypotension).

In rare cases, the following side effects may occur:

• atrioventricular block;

Bradycardiacharacterized by a decrease in the number of heartbeats below 60 beats per minute. Bradycardia is characterized by the appearance of symptoms such as general weakness, dizziness, cold sweats, as well as light-headedness or fainting as a result of oxygen starvation of the brain.

Atrioventricular block is a violation of the conduction of impulses from the atria of the heart to the ventricles. In some cases, atrioventricular block can cause heart rhythm disturbances.

Vasculitisis an inflammation of the vascular wall of arteries, veins and capillaries ( small vessels). As a result, the tissues and organs that are supplied with blood by the vessels affected by vasculitis undergo pathological changes. It should be noted that vasculitis is based on pathological immune processes.

Central nervous system and sensory disorders

To some extent, famotidine is able to affect the nerve cells of the brain. The most common side effect is headache, which is temporary.

When taking famotidine, the following side effects from the senses and the central nervous system may occur:

• dizziness;
• headaches;
• confusion of consciousness;
• nervousness;
• anxiety;
• increased fatigue;
• drowsiness;
• apathy;
• hallucinations ( very rarely);

Allergic manifestations

Famotidine can sometimes cause drug allergies. With increased individual sensitivity to the components of famotidine, in rare cases, rather life-threatening allergic manifestations can be observed.

While taking famotidine, the following types of drug allergies may occur:

• toxic epidermal necrolysis;
• stevens-Johnson syndrome.

Hivesis one of the most common types of drug allergies. It is characterized by the appearance of blisters of various sizes on the skin, which are very itchy. A skin rash can occur on a small segment of the skin or affect the entire skin. With this allergic reaction, nausea or vomiting can often occur, as well as pain in the abdomen.

Angioedema, or Quincke's edema, is a lesion of the hypodermis of the skin ( subcutaneous fat). Most often, the hypodermis of the face and extremities is affected, which leads to edema of varying severity. The most dangerous complication of angioedema is suffocation due to pronounced edema of the subcutaneous fat and laryngeal mucosa.

Toxic epidermal necrolysisis manifested by the appearance of a small-point rash on the skin. This rash after a short period of time drains, and then opens and leaves erosive areas. In toxic epidermal necrolysis, not only the skin is affected, but also internal organs such as the heart, kidneys, intestines and liver.

Anaphylactic shockis the most dangerous allergic reaction, in which the mortality rate is approximately 15 - 20%. An anaphylactic reaction, as a rule, occurs a few minutes after taking the medication and leads to swelling of the mucous membrane of the respiratory tract ( pharynx, larynx, bronchi), as well as a pronounced drop in blood pressure ( collapse).

Stevens-Johnson syndromecharacterized by the appearance of blisters on the skin and mucous membranes, which, when opened, leave extremely painful bleeding erosion. This rash can appear on the mucous membranes of the pharynx, mouth, mucous membranes of the eyes, and also on the genitals.

The approximate cost of the medication

Famotidine is sold in almost any pharmacy in Russia. Below is the price information for famotidine tablets.

City	Average cost of a medicine
	Film-coated tablets	Film-coated tablets
Moscow	35 rubles	27 rubles
Kazan	35 rubles	26 rubles
Krasnoyarsk	34 rubles	26 rubles
Samara	34 rubles	25 rubles
Tyumen	36 rubles	28 rubles
Chelyabinsk	37 rubles	28 rubles

Can Famotidine be taken for heartburn?

In some cases, famotidine can be used to treat heartburn. Most often it should be taken when antacids ( preparations of magnesium, aluminum, calcium or baking soda) did not bring the desired therapeutic effect and a more potent drug is required.

Heartburn, as a rule, occurs with gastroesophageal disease, which is characterized by the throwing of acidic stomach contents into the esophagus. Since the mucous membrane of the esophagus does not have a protective mechanism to neutralize hydrochloric acid, it is more susceptible to negative effects from gastric juice. In the future, inflammation of the esophageal mucosa occurs, which manifests itself in the form of heartburn ( burning or discomfort behind the breastbone). Famotidine reduces the production of hydrochloric acid and thus relieves heartburn.

Comparison of famotidine and antacids

Criteria	Famotidine	Antacids
The onset of the therapeutic effect	After 60 minutes.	After 10 to 15 minutes.
	On average 12-14 hours.	No more than 2 hours.
Acidic ricochet (an increase in the production of hydrochloric acid after the end of the action of the medication)	Doesn't possess.	Has an acidic rebound. In most cases, this phenomenon is caused by absorbed antacids ( rennie, tams, baking soda, burnt magnesia, calcium carbonate). After the end of the action of these medicines, the acidity of the stomach can increase by 30%.
The possibility of relapses	It greatly reduces the likelihood of recurrence of heartburn.	Does not reduce the likelihood of recurrence of heartburn.

At what age can a child be given famotidine?

Famotidine, as a rule, can be given to children from the age of twelve. It is from this age that the likelihood of various side effects while taking famotidine becomes insignificant. It should be noted that the age of twelve is conditional, since there is insufficient experience in the use of this antisecretory drug in children of younger age groups.

In some cases, a doctor may prescribe famotidine to a child over three years old ( the child's weight must exceed 10 kilograms) for the treatment of exacerbation of gastric ulcer and duodenal ulcer. In this case, it is prescribed to take 20 milligrams of medication twice a day or at the rate of 2 milligrams per 1 kilogram per day. The daily dosage should not exceed 40 milligrams. Also, the doctor may prescribe famotidine at an earlier age, taking into account the expected therapeutic benefits and potential risks to the child's health.

If the child has problems with taking famotidine tablets, then it is advisable to prescribe this antisecretory medication in the form of a suspension ( in liquid form).

Can I drink alcohol while on famotidine treatment?

It is highly recommended to completely limit the consumption of any alcoholic beverages during treatment with famotidine. The fact is that famotidine helps to reduce the production of hydrochloric acid, while alcohol increases its production. Drinking alcohol while taking famotidine may cause relapse ( re-exacerbation) gastrointestinal disease.

When alcohol is consumed, irritation of the stomach lining occurs. In response, the parietal cells of the stomach produce large amounts of hydrochloric acid. This mechanism is necessary to dilute ethyl alcohol, which can cause chemical burns to the mucous membrane. It should also be noted that when alcohol is consumed, gastric juice differs from normal. It contains much less of the enzyme pepsin, which is needed to break down protein foods in the stomach, resulting in poorer digestibility of food.

It should be noted that the systematic use of large doses of alcohol leads to pathological changes not only in the gastric mucosa, but also in the deeper layers. Compensatory mechanisms of the stomach to neutralize hydrochloric acid ( bicarbonate production) in this case are not effective enough. That is why alcohol abuse so often leads to gastritis, gastric ulcer and duodenal ulcer and other diseases of the gastrointestinal tract.

Which is better famotidine or omeprazole?

Most often, it is omeprazole that is the preferred medication over famotidine. Omeprazole is used to treat diseases such as gastroesophageal disease ( reflux of gastric contents into the esophagus), gastric ulcer and duodenal ulcer, dyspepsia ( disruption of the stomach against the background of increased production of hydrochloric acid) and other pathologies of the gastrointestinal tract.

Comparative characteristics of famotidine and omeprazole

Criteria	Famotidine	Omeprazole
Mechanism of action	Blocks H2-histamine receptors, which are located in the parietal cells of the gastric mucosa and thereby significantly inhibits the production of gastric juice. It also inhibits the production of the enzyme pepsin, which breaks down proteins into amino acids.	Violates the penetration of hydrogen and potassium ions into the parietal cells of the stomach ( is a proton pump inhibitor) as a result, there is a significant decrease in the production of hydrochloric acid and pepsin.
Duration of the therapeutic effect	On average 12-14 hours.	Within 22 - 24 hours.
Frequency rate of medication	Once a day.	Once or twice a day.
Side effects	Rarely.	Rarely.

Can famotidine tablets be taken while pregnant or while breastfeeding?

Famotidine should be used during pregnancy only for vital reasons. The fact is that famotidine, like many drugs, can cross the placenta into the fetal bloodstream. It should be noted that the effects of this drug on fetal health have not yet been adequately studied. Therefore, it must be prescribed with caution. The course of treatment with this antisecretory medication during pregnancy can only be prescribed by a doctor, taking into account the expected therapeutic effect on the health of the pregnant woman and taking into account the potential threat to the fetus.

Famotidine is also able to penetrate into breast milk. In the future, this antisecretory medication can enter the child's body in sufficiently large quantities with breast milk. An increased concentration of famotidine in the blood of a fetus or child can lead to serious side effects from the liver, central and peripheral nervous system, gastrointestinal tract and some other systems. It can also cause the child to develop an allergic reaction. In the event that a nursing mother was prescribed to take famotidine, then throughout the course of treatment, she should refuse breastfeeding in favor of using fermented milk or dry mixtures.

III generation histamine H2 receptor blocker.
Drug: FAMOTIDINE

The active substance of the drug: famotidine
ATX encoding: A02BA03
KFG: Blocker of histamine H2-receptors. Antiulcer drug
Registration number: P No. 014077/01
Date of registration: 17.06.08
Owner reg. ID: HEMOFARM KONCERN A.D. (Yugoslavia)

Release form Famotidine, drug packaging and composition.

Coated tablets, white or white with a grayish or yellowish tinge; cross-sectional white or almost white. 1 tab. famotidine 20 mg - "- 40 mg
Excipients: lactose, potato starch, colloidal silicon dioxide, magnesium stearate, talc.
Shell composition: hypromellose, polyethylene glycol (macrogol), titanium dioxide, glycerol, talc, lactose.
10 pieces. - contour cell packages (2) - cardboard packs.
10 pieces. - contour cell packages (3) - cardboard packs.

DESCRIPTION OF THE ACTIVE SUBSTANCE.
All the information provided is presented only for familiarization with the drug, you should consult your doctor about the possibility of use.

Pharmacological action Famotidine

III generation histamine H2 receptor blocker. Suppresses the production of hydrochloric acid, both basal and stimulated by histamine, gastrin and, to a lesser extent, acetylcholine. Simultaneously with a decrease in the production of hydrochloric acid and an increase in pH, the activity of pepsin decreases. The duration of action with a single dose depends on the dose and ranges from 12 to 24 hours.

Pharmacokinetics of the drug.

After oral administration, it is rapidly, but incompletely, absorbed from the gastrointestinal tract. Cmax in blood plasma is achieved after 2 hours. Bioavailability is 40-45% and changes slightly in the presence of food.
T1 / 2 from plasma is about 3 hours and increases in patients with impaired renal function. Protein binding is 15-20%. A small part of the active substance is metabolized in the liver to form famotidine S-oxide. Most of it is excreted unchanged in the urine.

Indications for use:

Treatment and prevention of recurrence of gastric ulcer and duodenal ulcer, reflux esophagitis, Zollinger-Ellison syndrome, diseases and conditions accompanied by increased secretion of gastric juice, prevention of erosive and ulcerative lesions of the gastrointestinal tract while taking NSAIDs; bleeding from the upper gastrointestinal tract (for intravenous administration, as part of a complex treatment).

Dosage and method of administration of the drug.

Individual, depending on the indications.
Inside for the purpose of treatment, 10-20 mg is used 2 times / day or 40 mg 1 time / day. If necessary, the daily dose can be increased to 80-160 mg. For the purpose of prevention - 20 mg 1 time / day before bedtime.
When administered intravenously, a single dose is 20 mg, the interval between injections is 12 hours.
With CC less than 30 ml / min or with a serum creatinine concentration of more than 3 mg / dL, it is recommended to reduce the dose to 20 mg / day.

Side effects of Famotidine:

From the digestive system: possible lack of appetite, dry mouth, taste disorders, nausea, vomiting, bloating, diarrhea or constipation; in some cases - the development of cholestatic jaundice, an increase in the level of transaminases in the blood plasma.
From the side of the central nervous system: possible headache, increased fatigue, tinnitus, transient mental disorders.
From the side of the cardiovascular system: rarely - arrhythmias.
From the hematopoietic system: very rarely - agranulocytosis, pancytopenia, leukopenia, thrombocytopenia.
From the musculoskeletal system: possible muscle pain, joint pain.
Allergic reactions: itching, bronchospasm, fever are possible.
Dermatological reactions: possible alopecia, acne vulgaris, dry skin.
Local reactions: irritation at the injection site.

Contraindications to the drug:

Pregnancy, lactation, hypersensitivity to famotidine.

Application during pregnancy and lactation.

Contraindicated for use during pregnancy and lactation.
Famotidine is excreted in breast milk.

Special instructions for the use of Famotidine.

Use with caution in patients with impaired renal and liver function.
Before starting treatment, it is necessary to exclude the possibility of a malignant disease of the esophagus, stomach or duodenum.
Does not change the activity of liver microsomal enzymes.
The interval between taking antacids and famotidine should be observed at least 1-2 hours.
Clinical experience with famotidine in children is limited.

Interaction of Famotidine with other drugs.

With simultaneous use with anticoagulants, the possibility of an increase in prothrombin time and the development of bleeding is not excluded.
With simultaneous use with antacids containing magnesium hydroxide and aluminum hydroxide, it is possible to reduce the absorption of famotidine.
With simultaneous use with itraconazole, it is possible to reduce the concentration of itraconazole in blood plasma and reduce its effectiveness.
With simultaneous use with nifedipine, a case of a decrease in cardiac output and cardiac output is described, apparently due to an increase in the negative inotropic effect of nifedipine.
With simultaneous use with norfloxacin, the concentration of norfloxacin in the blood plasma decreases; with probenecid - increases the concentration of famotidine in the blood plasma.
With simultaneous use, a case of an increase in the concentration of phenytoin in blood plasma with the risk of developing a toxic effect is described.
With simultaneous use, the bioavailability of cefpodoxime decreases, apparently due to a decrease in its solubility in the contents of the stomach with an increase in the pH of gastric juice under the influence of famotidine.
With simultaneous use with cyclosporine, a slight increase in the concentration of cyclosporine in the blood plasma is possible.

3D images

Composition and form of release

in a contour acheikova packing 10 pcs .; in a pack of cardboard 2 or 3 blisters.

Description of the dosage form

20 mg tablets: round, biconvex film-coated tablets, pale brown in color.

40 mg tablets: reddish-brown, round, biconvex film-coated tablets.

pharmachologic effect

pharmachologic effect - antiulcer.

Blocks histamine H 2 -receptors, inhibits the production of hydrochloric acid.

Clinical pharmacology

The duration of action with a single dose is from 12 to 24 hours.

Indications for Famotidine

Peptic ulcer of the stomach and duodenum (including prevention of exacerbations); symptomatic ulcers, erosive and reflux esophagitis; Zollinger-Ellison syndrome.

Contraindications

Hypersensitivity, pregnancy, lactation.

Side effects

Rarely - headache, dizziness, fatigue, dry mouth, lack of appetite, diarrhea or constipation, skin rash.

Interaction

Method of administration and dosage

Inside, swallowing whole (without chewing), drinking plenty of water. In case of gastric ulcer and duodenal ulcer in the acute phase, symptomatic ulcers, erosive gastroduodenitis - usually 20 mg 2 times a day or 40 mg 1 time per day at night. If necessary, the daily dose can be increased to 80-160 mg. The course of treatment is 4-8 weeks.

For dyspepsia associated with increased gastric secretory function - 20 mg 1-2 times a day.

In order to prevent recurrence of peptic ulcer disease - 20 mg 1 time per day before bedtime.

With reflux esophagitis - 20-40 mg 2 times a day for 6-12 weeks.

In Zollinger-Ellison syndrome, the dose of the drug and the duration of the course of treatment are set individually. The initial dose is usually 20 mg every 6 hours and may be increased to 160 mg every 6 hours.

For the prevention of gastric juice aspiration under general anesthesia - 40 mg in the evening and / or morning before surgery.

With renal failure (with Cl creatinine<30 мл/мин или содержании креатинина в сыворотке крови >3 mg / 100 ml), the daily dose of the drug must be reduced to 20 mg.

Precautionary measures

Before treatment, it is necessary to exclude the presence of a malignant process in the gastrointestinal tract. Use with caution in patients with impaired liver and kidney function.

Storage conditions of the drug Famotidine

In a dry, dark place at a temperature of 15-25 ° C.

Keep out of the reach of children.

Shelf life of the drug Famotidine

3 years.

Do not use after the expiration date printed on the package.

Instructions for medical use

Synonyms of nosological groups

ICD-10 heading	Synonyms for ICD-10 diseases
K20 Esophagitis	Digestive tract infections
	Gastrointestinal tract infection
	Acute erosion of the esophagus
	Esophagitis erosive
	Erosive esophagitis
K21 Gastroesophageal reflux	Biliary reflux esophagitis
	Gastroesophageal reflux disease
	Gastrocardiac syndrome
	Gastroesophageal reflux disease
	Gastroesophageal reflux
	Non-erosive reflux disease
	Gastrocardiac syndrome
	Remheld's syndrome
	Erosive reflux esophagitis
	Ulcerative reflux esophagitis
K25 gastric ulcer	Helicobacter pylori
	Pain syndrome with gastric ulcer
	Inflammation of the stomach lining
	Inflammation of the gastrointestinal mucosa
	Benign stomach ulcer
	Exacerbation of gastroduodenitis against the background of peptic ulcer
	Exacerbation of peptic ulcer
	Exacerbation of gastric ulcer
	Organic gastrointestinal disease
	Postoperative gastric ulcer
	Recurrence of ulcers
	Symptomatic stomach ulcers
	Helicobacteriosis
	Chronic inflammatory disease of the upper gastrointestinal tract associated with Helicobacter pylori
	Erosive and ulcerative lesions of the stomach
	Erosive lesions of the stomach
	Erosion of the gastric mucosa
	Peptic ulcer
	Stomach ulcer
	Ulcerative lesion of the stomach
	Ulcerative lesions of the stomach
K26 Duodenal ulcer	Pain syndrome in duodenal ulcer
	Pain syndrome in gastric ulcer and duodenal ulcer
	Disease of the stomach and duodenum associated with Helicobacter pylori
	Exacerbation of peptic ulcer
	Exacerbation of duodenal ulcer
	Peptic ulcer of the stomach and duodenum
	Recurrent duodenal ulcer
	Symptomatic gastric and duodenal ulcers
	Helicobacteriosis
	Helicobacter pylori eradication
	Erosive and ulcerative lesions of the duodenum
	Erosive and ulcerative lesions of the duodenum associated with Helicobacter pylori
	Erosive lesions of the duodenum
	Duodenal ulcer
	Ulcerative lesions of the duodenum
K31 Other diseases of stomach and duodenum	Discomfort in the stomach
	Mucosal stress injury