Human leukocyte interferon NPO Microgen. Human leukocyte interferon dry ampoule N10 Human leukocyte interferon

Instructions for medical use

drug

Human leukocyte interferon

Tradename

Human leukocyte interferon

International non-proprietary name

Interferon alpha

Dosage form

Lyophilisate for preparation of solution for intranasal administration 1000 IU

Composition

One ampoule contains

active substance -human leukocyte a-type interferon with antiviral activity of at least 1000 IU

Description

A porous amorphous mass or powder of white or light yellow to pink color. Hygroscopic.

Pharmacotherapeutic group

Immunomodulators. Immunostimulants. Interferons. Natural alpha interferon.

ATX code L03AB01

Pharmacological properties Pharmacokinetics

Pharmacokinetic studies have not been performed.

Pharmacodynamics

Human leukocyte interferon (Interferon alpha), a lyophilisate for preparing a solution for intranasal administration, is a group of proteins synthesized by leukocytes of donor blood in response to the effect of the interferon inducer virus.

Interferon alpha has the ability to stimulate the phagocytic activity of macrophages, as well as the cytotoxic activity of T-cells and "natural killers", has an indirect antiviral effect, inducing a state of resistance to viral infections in cells and modulating the response of the immune system aimed at neutralizing viruses or destroying those infected by them cells.

The preparation does not contain antibodies to human immunodeficiency viruses (HIV-1, HIV-2), hepatitis C virus and hepatitis B surface antigen (HBsAg).

Indications for use

Prevention and treatment of influenza and other acute respiratory viral infections

Method of administration and dosage

For the purpose of prevention

The introduction of the drug should be started with an immediate threat of infection and continue as long as the risk of infection persists. The drug is administered to adults and children from birth in the same dose by spraying or instilling an aqueous solution into the nose.

The ampoule with the drug is opened immediately before use. Sterile distilled or cooled boiled water is added to the ampoule to the line corresponding to 2 ml, gently shaken until the contents are completely dissolved. The dissolved preparation is a transparent or slightly opalescent liquid, colorless or from light yellow to pink. The dissolved preparation can be stored for 24 hours at a temperature of 2 ° C to 8 ° C.

Spraying can be done with sprays of any system in accordance with the instructions attached to them. In each nasal passage, 0.25 ml of solution should be injected twice a day with an interval of at least 6 hours. When instilling the drug, 5 drops are injected into each nasal passage 2 times a day with an interval of at least 6 hours.

The drug is used in the same dose for adults and children from birth by spraying or nasal instillation.

When spraying or instilling, the drug is dissolved in 2 ml of water and 0.25 ml (5 drops) is injected into each nasal passage after 1-2 hours at least 5 times a day for 2-3 days.

Side effects

During the use of the drug, side effects were not registered.

Contraindications

Hypersensitivity to interferon preparations

Drug interactions

It is allowed to be used simultaneously with other topical antiviral drugs and congestants.

special instructions

The introduction of the drug by injection is strictly prohibited!

Use with caution for persons with allergic diseases.

In case of immediate allergic reactions, symptomatic therapy should be carried out.

Application in pediatrics

For children from the neonatal period (from birth), the drug is applied by spraying or instillation.

Pregnancy and lactation

In this article, we will talk about one of the effective antiviral and immunostimulating drugs. It's about human leukocyte interferon. We will analyze the properties of the drug, indications for its purpose, instructions for use, etc.

Characteristics of the drug

Leukocyte human interferon (international name - interferon alpha) is available in two forms - a solution for inhalation and intranasal use and a dry lyophilized powder (sometimes compressed into tablets). The liquid form has a shade from colorless to light pink, dry - from white to pinkish.

Human leukocytic interferon (Interferon leukocytic human) is a complex of proteins that are synthesized by leukocytes of donor blood under the influence of the interferon inducer virus. They are purified by ultra- and microfiltration methods.

Analogues of this immunomodulatory drug:

• "Lokferon".
• "Inferon"
• "Nazoferon" and others.

The tool can be used in combination with other medicines. The drug is dispensed without a doctor's prescription and is valid for 2 years from the date of manufacture. It must be stored in a cool, dark (2-8 degrees above zero) place protected from light. Keep out of the reach of children!

Average prices for human leukocyte interferon are relatively low. So, in most pharmacies, a pack of 10 ampoules of the drug will cost 80-120 rubles.

Composition of the preparation

1 ml of liquid human leukocyte interferon contains:

• Interferon alpha - 1000 IU.
• Sodium chloride - 0.09 mg.
• Sodium dihydrogen phosphate dihydrate - 0.06 mg.
• Sodium hydrogen phosphate dodecahydrate - 0.003 mg.
• Distilled water for injection - about 1 ml.

Pharmacological properties

This immunomodulatory drug belongs to the pharmacological group of cytokines. Its properties are distinguished as follows:

• Immunostimulation - makes the immune response stronger.
• Immunomodulation - normalizes the immune status.
• Antibacterial effect - fight against various types of mixed infections.
• Antiviral action - helps the body to resist diseases such as herpes, flu, adenoviral diseases.
• Anti-inflammatory, anti-tumor effect.

Dry and liquid product is non-toxic, sterile, harmless when administered through the respiratory tract. In this case, the use of powder for injection is prohibited.

Indications for use

Human leukocyte interferon is used both for the prevention of acute viral infections and for the treatment of early forms of disease with initial symptoms.

Indications can be divided into three main groups:

• Intranasal administration: preventive measures and treatment of acute respiratory viral infections, influenza.
• Parenteral administration: genital warts, hepatitis B and C, non-Hodgkin's lymphoma, malignant melanoma, multiple myeloma, renal carcinoma, Kaposi's sarcoma in AIDS sufferers (not suffering from acute infections at this time), hairy cell leukemia, fungal mycosis.
• Rectal administration: therapy of chronic and acute viral hepatitis.

Also, the drug will be effective for:

• chronic myeloid leukemia;
• primary and secondary thrombocytosis;
• transitional stage of chronic granulocytic leukemia, myelofibrosis;
• reticulosarcoma;
• multiple sclerosis.

Contraindications

Instructions for the use of human leukocyte interferon indicate the following contraindications to the use of the drug:

• Epilepsy.
• Dysfunction of the central nervous system.
• Dysfunction of the kidneys and liver, hematopoietic system.
• Organic heart disease.
• Chronic hepatitis in individuals whose recent treatment has consisted of immunosuppressive drugs.
• Diseases of the thyroid gland.
• Chronic hepatitis.
• Liver cirrhosis with signs of liver failure.
• Pregnancy and lactation.
• Allergy.
• Increased individual sensitivity to the active ingredient - interferon alpha, as well as to all preparations of protein origin, to chicken and eggs.

The drug is dangerous to take in the following cases:

• The expiration date has expired.
• The integrity of the packaging is broken.
• There is no marking on the container.

Dosage and administration

Instructions for the use of human leukocyte interferon prescribe:

• For children under 3 years of age, inject the drug only intranasally (spray, instillation).
• Children from 3 years old, adults are additionally allowed inhalation.

Intranasal administration... The ampoule with the medicine is opened immediately before use. Then cooled boiled or sterile distilled water is added to it strictly up to the line of 2 ml on the capsule. The product is gently shaken until completely dissolved.

The drug is instilled into the nose using a syringe without a needle or a medical pipette. Another method is spraying: you can use either a third-party sprayer or the one that comes with the drug. The nozzle is put on the syringe without a needle, then brought close to the nasal passage or going into it about 0.5 cm. Spraying occurs by pressing the syringe plunger. In this case, the patient should sit with his head thrown up.

Drug dosage:

• Prophylaxis: applied throughout the risk of infection. Instillation - 5 drops, spraying - 0.25 ml into each nasal passage. The manipulation is carried out up to 2 times per day with an interval of at least 6 hours.
• Treatment: when the first signs of the disease appear. 5 drops or 0.25 mg in each nostril. The procedure is repeated up to 5 times a day with an interval of 1-2 hours.

Human leukocyte interferon for children and adults is administered in equal doses.

Inhalation... Inhaled use is considered to be more effective. For him, you need to purchase an inhaler from any manufacturer. One procedure requires the contents of three capsules, which should be dissolved in 10 ml of water heated to 37 degrees. In this way, the drug is administered through the mouth and nose twice a day for 2-3 days.

It is prohibited to inject the product by injection!

Side effects

When using this immunomodulatory drug, the following side effects are possible:

• From the gastrointestinal tract: change in taste, dry mouth, flatulence, constipation, vomiting, diarrhea, nausea, loss of appetite. In rare cases, liver dysfunction.
• From the side of the central nervous system: ataxia, drowsiness or sleep disturbance, impaired consciousness, depression, nervousness.
• On the part of the heart and blood vessels: arrhythmia, arterial hypotension.
• Dermatological consequences: skin rash, slight alopecia, erythema, dry skin.
• Flu-like syndrome: weakness, fever, myalgia, headache.
• Other: granulocytopenia, feeling of weakness, lethargy, weight loss, blurred vision, dizziness.

special instructions

The agent should be used with caution when:

• Recently suffered myocardial infarction.
• Myelodepression, changes in blood clotting.
• Elderly patients who have been diagnosed with side effects from the central nervous system when using high doses of the drug. It may even be worth stopping treatment.
• Patients with hepatitis C should be tested for TSH levels in the blood before treatment. Only at normal rates can interferon therapy be started. In other cases, thyroid dysfunction is possible.
• Combination with opioid analgesics, hypnotics, sedatives.

Human leukocyte interferon is an effective immunostimulating anti-infective agent. It has a number of features of use and contraindications, therefore, before use, familiarity with the instructions is necessary.

Composition and release form of the drug

Lyophilisate for preparation of solution for intranasal administration and inhalation.

1000 IU - ampoules (10) - cardboard packs.
1000 IU - ampoules (5) - cardboard packs.
1000 IU - ampoules (10) - contoured cell packs (1) - cardboard packs.
1000 IU - ampoules (10) - general cardboard packs.
1000 IU - ampoules (5) - general cardboard packs.

pharmachologic effect

Interferon alpha is a mixture of various subtypes of natural alpha interferon from human blood leukocytes. It has an immunostimulating and antiproliferative effect. The antiviral effect of the drug is mainly based on an increase in the resistance of body cells not yet infected with the virus to possible effects. By binding to specific receptors on the cell surface, interferon alpha changes the properties of the cell membrane, stimulates specific enzymes, affects the RNA of the virus and prevents its replication. The immunomodulatory effect of interferon alpha is associated with the stimulation of the activity of macrophages and NK (Natural killer) cells, which, in turn, are involved in the body's immune response to tumor cells.

Indications

For parenteral use: hepatitis B and C, genital warts, hairy cell leukemia, multiple myeloma, non-Hodgkin's lymphomas, fungal mycosis, Kaposi's sarcoma in patients with AIDS who have no history of acute infections; renal carcinoma; malignant melanoma.

For rectal administration: treatment of acute and chronic viral hepatitis.

For intranasal use: prevention and treatment of influenza, ARVI.

Contraindications

Severe organic heart disease, severe liver or kidney dysfunction; epilepsy and / or dysfunction of the central nervous system; chronic hepatitis and cirrhosis of the liver with symptoms of liver failure; chronic hepatitis in patients receiving or recently receiving treatment (with the exception of GCS treatment); autoimmune hepatitis; thyroid diseases resistant to traditional therapy; confirmed hypersensitivity to interferon alpha.

Dosage

The dose, frequency and duration of use are set depending on the indications, the severity of the disease, the route of administration, and the individual response of the patient.

Side effects

With parenteral administration, side effects are observed much more often than with other routes of administration.

Flu-like symptoms: fever, myalgia, weakness.

From the digestive system: loss of appetite, nausea, vomiting, diarrhea; rarely - liver dysfunction.

On the part of the cardiovascular system: arterial hypotension, arrhythmia.

From the side of the central nervous system: drowsiness, impaired consciousness, ataxia.

Dermatological reactions: rarely - minor alopecia, dry skin, erythema,.

Others: general weakness, granulocytopenia.

Drug interactions

Since interferons inhibit oxidative metabolism in the liver, the biotransformation of drugs metabolized in this way may be impaired.

With simultaneous use with ACE inhibitors, synergism with respect to hematotoxic action is possible; c - synergism in relation to myelotoxic action; with paracetamol - it is possible to increase the activity of liver enzymes; with theophylline - a decrease in the clearance of theophylline.

special instructions

Use with caution in patients with a history of indications of a recent myocardial infarction, as well as in cases of changes in blood coagulation and myelodepression.

For thrombocytopenia with a platelet count of less than 50,000 / μl, subcutaneous administration should be used.

Patients should receive hydration therapy, especially during the initial period of treatment.

In patients with hepatitis C receiving interferon alpha therapy for systemic use, thyroid dysfunction may occur, manifested in hypo- or hyperthyroidism. Therefore, before starting the course of treatment, the level of TSH in the blood serum should be determined and treatment should be started only if the level of TSH in the blood is normal.

Use interferon alfa with caution with hypnotics, sedatives, opioids.

Contraindicated in severe liver dysfunction, chronic hepatitis and liver cirrhosis with symptoms of liver failure; chronic hepatitis in patients receiving or recently receiving treatment with immunosuppressants (except for GCS treatment); autoimmune hepatitis.

Use in the elderly

With the development of side effects from the central nervous system in elderly patients receiving interferon alfa in high doses, a thorough examination should be carried out and, if necessary, treatment should be interrupted.

Interferon is a drug that has a direct effect on the body's immune system. It has a pronounced antiviral, antiproliferative and antitumor effect.

Release form and composition

The active ingredient of the drug Interferon is a specific protein synthesized by human leukocytes.

The medicine is available in the following forms:

• Freeze-dried powder;
• Solution for topical use;
• Injection;
• Rectal suppositories.

Indications for use

According to the instructions attached to Interferon, indications for its use depend on the form of release of the drug.

Injection:

• Hepatitis B and C;
• Genital warts;
• Leukemia, hairy cell leukemia - tricholeukemia;
• Tick-borne encephalitis;
• Condition after surgical treatment of respiratory papillomatosis of the larynx;
• Multiple myeloma;
• T-cell lymphoma - fungal mycosis;
• Non-Hodgkin lymphomas;
• Chronic myeloid leukemia;
• Reticulosarcoma;
• Kaposi's sarcoma in patients with acquired immunodeficiency syndrome;
• Malignant melanoma;
• Thrombocytosis - primary (essential) and secondary;
• Chronic granulocytic leukemia and myelofibrosis are transitional forms.

Interferon in the form of suppositories:

• Hemorrhagic fever with renal syndrome;
• Viral hepatitis;
• Immunodeficiency states that are secondary.

Lyophilized powder and topical solution:

• Prevention and treatment of influenza, ARVI;
• Diseases of the eyes of viral etiology.

Contraindications

The use of Interferon is contraindicated in the following diseases and conditions:

• Hypersensitivity;
• Chronic heart failure;
• Acute myocardial infarction - acute period;
• Autoimmune diseases;
• Diabetes mellitus - severe forms;
• Lung disease;
• Hepatic or renal failure;
• Chicken pox;
• Cirrhosis of the liver;
• Diseases of the thyroid gland;
• Severe mental disorders, epilepsy;
• Lactation period.

The use of Interferon requires caution in postinfarction cardiosclerosis, arrhythmias, herpes simplex, impaired bone marrow hematopoiesis, as well as during pregnancy.

Method of administration and dosage

According to the instructions, Interferon in an injection solution should be used parenterally - subcutaneously, intramuscularly or intravenously. The dosage depends on the nature of the disease and the age of the patient.

Interferon in the form of a powder and solution for topical application is used intranasally and conjunctivally. The drug is administered by inhalation using an inhaler of any system or by instilling an aqueous solution - the powder is diluted before use in 2 ml of distilled or cooled boiled water.

In order to prevent influenza and SARS, the medicine is instilled in 5 drops into each nasal passage twice a day with an interval of 6 hours.

For the purpose of treatment, the drug Interferon should be used at an early stage of the disease when the first symptoms of malaise appear, 5 drops after 1-2 hours at least 5 times a day for 2-3 days.

In ophthalmic practice in the acute period of the disease, the drug is administered in 2-3 drops in each eye from 3 to 10 times a day. When the condition improves - up to 5-6 times during the day. The course of treatment is no more than 14 days.

Interferon in the form of suppositories is used rectally for hemorrhagic fever, acute hepatitis B in children, and secondary immunodeficiency states. The dosage is determined individually, the duration of treatment is no more than 14 days.

Side effects

The use of Interferon, especially when administered parenterally, may cause the following side effects:

• Flu-like syndrome - headache, myalgia, fever, chills;
• Decreased appetite, impaired stool, nausea, vomiting, dryness of the oral mucosa, heartburn, liver failure;
• Anemia, a decrease in the number of leukocytes and platelets in the blood;
• Pressure fluctuations, chest pain, arrhythmias;
• Dizziness, decreased cognitive function and concentration, sleep disturbance, drowsiness, numbness of the limbs or face, confusion, paresthesia, cramps of the calf muscles;
• Blurred vision, ischemic retinopathy;
• Dry skin, rash, itching, hair loss, hyperhidrosis;
• Disruption of the thyroid gland.

special instructions

During treatment with the antiviral drug Interferon, it is necessary to monitor blood counts and liver function. With severe thrombocytopenia, the drug should be administered subcutaneously.

In case of side effects from the central nervous system in patients receiving high doses of the drug, additional examination is required, if necessary, the drug should be canceled.

To reduce the severity of influenza-like syndrome, parallel administration of paracetamol is indicated.

At the initial stage of treatment with Interferon, hydration therapy is necessary.

In patients with hepatitis C, the antiviral agent can cause dysfunction of the thyroid gland, so its use should be started only when hormone levels are normal.

During the period of use of the drug Interferon, care must be taken when driving vehicles and other moving mechanisms.

Analogs

The synonyms of Interferon include drugs Alfaferon, Diaferon, Interlock, Inferon, Leukinferon, Lokferon.

Similar pharmacological action is possessed by drugs such as:

• Avonex;
• Altevir;
• Betaferon;
• Viferon;
• Genfaxon;
• Genferon;
• Ingaron;
• Layfferon;
• Reaferon;
• Extavia;
• Rebif;
• Ronbetal and others.

Terms and conditions of storage

According to the instructions attached to Interferon, the drug should be stored in a dry place at a temperature of 2-8 ° C.

Expiration date - 1 year.

Human leukocyte interferon is a unique product with pronounced immunomodulatory and immunostimulating capabilities. This drug is able to reduce the growth of tumors, which is achieved due to the presence of interferon alpha in it.

The latter is understood as a group of proteins produced by human blood leukocytes. They help our body fight a large number of viral, fungal, infectious and other diseases.

Indications for use

What helps to cure leukocyte interferon? With proper and timely use, it accelerates recovery in the case of such ailments:

• respiratory system infections;
• bacterial infections;
• immunodeficiency;
• viruses;
• benign and malignant neoplasms;
• renal and hepatic diseases;
• infections of fungal origin;
• pathology of the mucous membranes and eyes.

Leukocyte interferon is used to prevent these health problems and to strengthen the immune system in general.

The drug is included in the complex therapy of many pathologies, and its dosage is prescribed only on an individual basis.

Release forms

Interferon is available in ampoules, in the form of suppositories, ointments and in the form of a dry powder - a lyophilized substance. The latter must be diluted with saline, while the substance in ampoules is already ready for use.

pharmachologic effect

Human protein, which is interferon, is able to exert its healing effects immediately after it enters the body. It inhibits the activity of pathological microorganisms and increases the protective abilities of the body as a whole.

Due to the latter property, a person who has consumed the powder may have a slight rise in temperature, which is considered an adequate response to an increase in the concentration of interferon in the blood. As you already know, the vast majority of bacteria and viruses die already at 37 degrees.

Interferon for children

• Interferon ampoules

Inhalation based on human protein is quite effective. For them, you need to dissolve the contents of three ampoules in 10 ml of boiled water and do the procedures for irrigating the oral (nasal) cavity twice a day.

• Interferon powder

Having bought the dry form of the drug, the powder in a glass pharmaceutical container must be diluted with two milliliters of warm boiled water. The interval between instillations is 6 hours, while the general course lasts until the threat of virus infection passes.

If human interferon is used for intensive treatment, it must be diluted in the same way (for the powder form), but drip after a couple of hours, again, five drops into each nostril of the child.

• Interferon ointment

Interferon in the form of an ointment is a convenient everyday remedy for viruses. It can be used to treat not only the nostrils, but also the tonsils.

• Interferon candles

As for suppositories, they are often recommended for use in newborns or when a therapeutic effect must be achieved as quickly as possible. Once in the rectum, human interferon instantly enters the bloodstream and begins its healing effect. It is customary to inject the remedy rectally every 12 hours, but not more than five days in a row.

Interferon for adults

1. Eye pathologies: the powder is diluted with one milliliter of boiled water and buried under the lower eyelid. The procedure needs to be repeated 10 times a day, while the general course can take two days or a couple of weeks;
2. Viral, bacterial and colds of the respiratory tract: the powder is diluted in 2 ml of warm boiled water and on the first day of the illness 1-3 drops are injected into each nostril at intervals of 2 hours. Then interferon is divided into 5 doses maximum;
3. Immunodeficiency, as well as the condition in case of benign and malignant neoplasms, is corrected according to the following scheme: Interferon powder is diluted with saline and injected intramuscularly. If an intravenous injection is needed, sodium chloride is used for dilution.

Contraindications for use

Protein instructions categorically do not recommend including the drug in treatment regimens if the following deviations are available:

• Personal intolerance to the substance in its pure form;
• Increased susceptibility to chicken protein;
• Intolerance to antibiotics;
• Complex organic pathologies;
• Dysfunction of the central nervous system;
• Malfunctions of the liver, thyroid gland or kidneys;
• Chronic hepatitis;
• Cirrhosis of the liver;
• Taking sedatives or immunosuppressants;
• Use of strong hypnotics or opioid analgesics.

Interferon and alcohol

Dry powder is unacceptable for use in a company with alcohol.

Alcohol greatly diminishes the positive properties that drugs based on it carry with them, and provokes a large number of side effects in the form of:

• vomiting and nausea;
• depression;
• headaches and dizziness;
• rapid heartbeat;
• suppressing appetite;
• suicidal conditions;
• changes in liver function, etc.

The most interesting thing is that the effect of synthetically produced protein on the human body has not yet been fully studied, and doctors are finding new indications for its use. Hence, a logical conclusion follows: the consequences of taking the drug in tablets or intramuscularly, supplemented by alcohol consumption, can be completely unpredictable, and it is good if everything ends with allergies or one-time vomiting.