Composition of the medicinal product Vitamin B-1

The active substance is thiamine. pharmachologic effect

Dosage form

soft capsules 100mg, soft capsules 400mg, solution 6%, injection 50mg / ml

Pharmacotherapeutic group

Thiamine group (vitamin B1)

Pharmacological properties

Pharmacological action - replenishing vitamin B1 deficiency, metabolic, immunostimulating, antioxidant, ganglion blocking. After oral administration, it is absorbed mainly in the duodenum and small intestine. It is quickly and completely absorbed by intramuscular injection. It is distributed over all tissues. The daily requirement for vitamin B1 for adult men is from 1.2 to 2.1 mg; for the elderly - 1.2-1.4 mg; for women - 1.1-1.5 mg with the addition of 0.4 mg for pregnant women and 0.6 mg for lactating women; for children, depending on age, - 0.3-1.5 mg. In the form of thiamine pyrophosphate, as a coenzyme of numerous decarboxylases, it participates in the metabolism of pyruvate, alpha-ketoglutarate and plays an important role in the metabolism of carbohydrates. Protects cell membranes from the toxic effects of peroxidation products.

Vitamin B-1 - indications for use

Hypovitaminosis and vitamin deficiency B1 (including in patients on tube feeding, on hemodialysis, suffering from malabsorption syndrome), reduced intake of vitamin into the body - impaired absorption in the intestine, starvation, chronic alcoholism, severe liver dysfunction, thyrotoxicosis, increased the need for a vitamin - pregnancy, lactation, a period of intensive growth; neuritis, sciatica, neuralgia, peripheral paresis or paralysis, intestinal atony, myocardial dystrophy, dermatoses, lichen, psoriasis, eczema, intoxication.

Contraindications

Hypersensitivity.

Cautions for use

There is no data.

Drug interactions

Weakens the effect of depolarizing muscle relaxants (ditilin, etc.). Pyridoxine inhibits the conversion of thiamine into thiamine pyrophosphate, increases allergy. Pharmaceutically incompatible (in one syringe) with penicillin, streptomycin, nicotinic acid.

Vitamin B1 (thiamine) - physiological role, deficiency symptoms, content in food. Instructions for the use of vitamin B1

Thank you

The site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. A specialist consultation is required!

Vitamin B 1 is a water-soluble sulfur-containing compound. Vitamin can be in several forms, depending on the characteristics of the chemical orientation of atoms in the molecule, however, the greatest biological and physiological significance is thiamine pyrophosphate... It is in the form of thiamine pyrophosphate that vitamin B 1 is most often found in the tissues of the body and, accordingly, performs its physiological and biological functions. However, for brevity, doctors and scientists often neglect the full name of the most active chemical form of vitamin B 1, calling it simply thiamine... In the further text of this article, we will also use the names "thiamine" and "vitamin B 1" to denote the active form of a substance in which it exerts its biological effects.

Vitamin B 1 name

Currently, the following names are used to denote vitamin B 1:
1. Thiamine;
2. Thiamine pyrophosphate;
3. Thio vitamin;
4. Anevrin.

The most commonly used name is thiamine, the rest are rarely used. The name "thiamine" was derived from "thio-vitamin", where the prefix "thio" denoted the presence of sulfur atoms in the vitamin B 1 molecule. Then the last letter o was removed from the prefix "thio", and the first three letters "vit" were removed from the word "vitamin", and the remaining parts were combined into one word - thiamine.

The name thiamine pyrophosphate is the chemical name for the active form of the vitamin, in which it performs its functions in tissues and cells. This name is rarely used, as a rule, only in specialized scientific literature.

The name of vitamin B 1 "aneurin" was coined because of the neurological disorders that occur when it is lacking. However, at present, this name is practically not used in popular science and scientific literature.

What is vitamin B 1 (thiamine) for - physiological role

Vitamin B 1 regulates the metabolism of carbohydrates and fats (lipids) in all organs and tissues of the human body. Thanks to thiamine, every cell of the human body produces the energy necessary to maintain vital activity and perform specific functions. Since for the reproduction of cells it is necessary to copy the genetic material - DNA helices, which also requires energy, vitamin B 1 is also involved in the process of preparing for cell division. Thus, we can conditionally say that the physiological function of vitamin B 1 is to provide cells with the necessary energy.

However, many may disagree with this formulation, since everyone knows that the human body receives energy from fats and carbohydrates. Moreover, fats provide more energy, but are broken down longer, and carbohydrates, accordingly, have a lower energy value, but are metabolized very quickly. This is true, but there is a significant nuance.

The fact is that the cells of the human body use energy only in the form of a molecule of ATP (adenosine triphosphoric acid), which is called a universal energy compound. Cell organelles cannot use energy in any other form. This means that carbohydrates and fats must be converted into ATP molecules after being absorbed into the bloodstream so that cells can use the energy received from food. If lipids and carbohydrates do not turn into ATP molecules, then the cell will not be able to use their energy potential and will remain "hungry". That is, a situation will be created when the cell is starving against the background of a huge amount of food. To better understand this situation, you need to imagine a table full of delicious dishes, which is located behind a high fence and there is no way to get to it.

The process of converting lipids and carbohydrates into ATP occurs in several cycles of biochemical reactions, which are triggered, maintained and regulated by vitamin B 1. That is, thiamine is a vitamin necessary for converting carbohydrates and fats from food into a form in which the cell can assimilate and use them for its own needs. And since energy and nutrition are necessary for every cell of any organ and tissue, the importance of the physiological function of vitamin B 1 is obvious. With thiamine deficiency, cells begin to experience hunger from the lack of ATP, they cannot reproduce normally, effectively carry out specific organ functions, etc. And this entails many different violations in the work of almost all organs and systems.

But first of all, the nervous system suffers, which especially badly needs a constant influx of ATP, since its cells do not have even a meager supply of an energy molecule, which is consumed very intensively to ensure fast transmission of impulses through the fibers. Vitamin B 1 is essential for the transmission of nerve impulses along fibers from cells to the brain and back to organs and tissues. And, therefore, the very first and most noticeable symptoms of vitamin B 1 deficiency are impaired transmission of nerve impulses, and, consequently, the development of muscle dysfunction, tics, weak sensitivity, etc.

At the level of organs and systems, vitamin B 1 has the following physiological effects:

• Improves mental and cognitive abilities (memory, attention, thinking, abstraction, etc.);
• Normalizes mood;
• Improves brain function;
• Increases learning ability;
• Stimulates the growth of bones, muscles, etc.;
• Normalizes appetite;
• Improves microcirculation and blood formation;
• Slows down the aging process;
• Reduces the negative effects of alcohol and tobacco;
• Supports muscle tone in the digestive tract;
• Supports the tone and normal functioning of the heart muscle (myocardium);
• Eliminates motion sickness and relieves motion sickness;
• Reduces toothache after various dental procedures.

Absorption and excretion of vitamin B 1

Vitamin B 1 is actively and rapidly absorbed into the bloodstream from the small intestine. However, the absorption of thiamine is a saturable process, that is, the amount of the vitamin, the ability to enter the bloodstream within a certain period of time, is limited. So, a maximum of 10 mg of vitamin B 1 can be absorbed from the small intestine into the blood per day. That is why the maximum daily dose of thiamine is 10 mg, because a larger amount is simply not absorbed into the bloodstream, but is excreted from the body with feces.

If there are any diseases of the digestive tract associated with damage to their structure, for example, stomach or duodenal ulcer, colitis and others, then the absorption of vitamin B 1 is difficult. As a result, less than 10 mg of thiamine is absorbed from the intestine during the day.

After entering the blood, vitamin B 1 is carried to various organs and tissues, penetrating the blood-brain barrier to the brain cells and to the fetus. After entering the cells, thiamine performs its physiological functions.

After fulfilling its functions, vitamin B 1 undergoes phosphorylation and subsequent destruction in liver cells. Substances resulting from the destruction of phosphorylated thiamine are called metabolites and are excreted from the body by the kidneys in the urine.

Lack of vitamin B 1

Since vitamin B 1 is not able to accumulate in tissues and form any significant reserve, for the normal functioning of the body it is necessary to ensure its intake with food every day. If a person receives an insufficient amount of thiamine with food, then its deficiency develops, which can manifest itself in two clinical forms - hypovitaminosis or vitamin deficiency. With hypovitaminosis, there is a moderate deficiency of vitamin B 1 and clinical symptoms of deterioration in the functions of the nervous, cardiovascular and digestive systems. With avitaminosis, there is a deep deficiency of vitamin B 1, which manifests itself in severe diseases such as beriberi, Korsakov's syndrome, etc.

Clinical manifestations of thiamine deficiency are caused by impaired carbohydrate, fat and protein metabolism with a low rate of formation of a universal cellular energy source - the ATP molecule. Due to the deficiency of thiamine, carbohydrates from food are not processed in the cycles of biochemical reactions into ATP, as a result of which they accumulate with partial use in other cascades of transformations. As a result, products of incomplete processing of carbohydrates, such as lactic acid, pyruvate, etc., accumulate in the blood. These carbohydrate metabolites penetrate the cells of the brain and spinal cord and disrupt their work, since they are highly toxic substances for them.

In addition, due to the deficiency of ATP molecules, the normal functioning of nerve, heart and muscle cells is disrupted, which is manifested by atrophy, constipation, neurological disorders, etc. In children, due to a lack of energy obtained from carbohydrates, proteins and fats are consumed, which leads to delays in physical development.

Thiamine is also used for the synthesis of a special substance - acetylcholine, which is called a neurotransmitter, since it transmits a signal from a nerve cell to an organ. Accordingly, the normal transmission of nerve impulses from the brain and spinal cord to the muscles of the internal organs is disrupted, as a result of which constipation, low secretion of gastric juice, tics, gait instability, etc. develop.

Symptoms of B 1 hypovitaminosis are the following manifestations:

• Tearfulness;
• Insomnia and superficial poor sleep;
• Increased fatigue;
• Inability to concentrate on any subject;
• Poor memory;
• Chilliness at normal air temperature indoors or outdoors;
• Deterioration in motor coordination;
• Sluggish appetite;
• Shortness of breath with little physical exertion;
• Shaking hands;
• Obsessive thoughts;
• Feeling of inferiority;
• Muscle weakness;
• Tachycardia with an uneven and indistinct rhythm;
• Pain in the calves;
• Feeling of heat or burning on the skin of the upper and lower extremities;
• Reduced pain threshold;
• Hypotonic constipation;
• Low blood pressure (hypotension);
• Swelling of the hands and feet;
• Enlargement of the liver.

With hypovitaminosis of thiamine in humans, almost all of the listed symptoms are usually observed. However, the degree of their severity is the stronger, the greater the deficiency of vitamin B 1 a person has.

With a deep thiamine deficiency, vitamin deficiency develops, which manifests itself as a characteristic beriberi disease, which has the following symptoms:

• The headache is almost constant;
• Poor memory;
• Peripheral nerve polyneuritis;
• Tachycardia and heart pain;
• Dyspnea;
• Lack of appetite;
• Nausea;
• Obstinate constipation;
• Staggering gait;
• Amyotrophy;
• General weakness.

Currently avitaminosis B 1 with classic manifestations of the disease take it is rare. However, in developed countries, people who abuse alcohol have a special form of beriberi called Wernicke-Korsakoff syndrome or Gaie-Wernicke syndrome. Also, alcoholics can develop a special variant of thiamine deficiency called optic neuropathy.

When optic neuropathy there is a significant loss of vision in both eyes, a central scotoma (spot in front of the eye) develops and perception and color discrimination are impaired. Examination of the structures of the eye usually reveals swelling of the optic disc and atrophy of the optic nerve.

Wernicke-Korsakoff syndrome characterized by impaired cognitive abilities (memory, attention, ability to analyze and learn, etc.), paralysis of eye movements, impaired standing and walking, as well as mental disorders. Wernicke-Korsakoff syndrome most often develops with alcohol abuse, since the latter impairs the absorption of thiamine from the intestine. Less commonly, the causes of Wernicke-Korsakoff syndrome are diseases of the digestive tract, HIV / AIDS, large doses of glucose administered intravenously, or excessive consumption of carbohydrate foods (potatoes, flour products, sweets).

Vitamin B 1 in foods - where it contains the maximum amount

Vitamin B 1 is found in the maximum amount in meat products, nuts, yeast, and grain. The following foods contain high amounts of thiamine:

• Pine nuts (33.8 mg of vitamin B 1 in 100 g of the product);
• Brown rice (2.3 mg);
• Sunflower seeds (1.84 mg);
• Pork meat (1.45 mg);
• Pistachios (1.0 mg);
• Peas (0.9 mg);
• Peanuts (0.7 mg);
• Pork bacon (0.60 mg)
• Yeast (0.60 mg);
• Lentils, beans and soybeans (0.50 mg)
• Whole oatmeal (0.49 mg);
• Buckwheat (0.43 mg);
• Millet groats (0.42 mg);
• By-products of farm animals and birds - liver, lungs, kidneys, stomach, heart, brain (0.38 mg);
• Whole wheat bread (0.25 mg);
• Chicken egg (0.12 mg);
• Asparagus, potatoes and cauliflower (0.10 mg)
• Oranges (0.09 mg).

In principle, many vegetables contain moderate amounts of vitamin B 1, such as broccoli, onions, beans, pumpkin, carrots, tomatoes, green peas, beets, Brussels sprouts, spinach, and eggplant. Therefore, the consumption of these vegetables in combination with cereals or wholemeal bread will provide the body with the necessary amount of vitamin B 1.

P # 015467/01

Trade name of the drug: Thiamine chloride

International non-proprietary name:

Thiamine

Chemical name:(4-methyl-5-beta-hydroxyethyl-N- (2methyl-4-amino-5 methylpyrimidyl) thiazolium chloride hydrochloride).

Dosage form:

solution for intramuscular administration.

Structure:

Thiamine chloride 50g
Unitiola 2g
Water for injection up to 1 liter.

Description: Colorless or slightly colored transparent liquid with a weak characteristic odor.

Pharmacotherapeutic group:

an agent that regulates metabolic processes. Vitamin preparation. ATX code: A11DA01.

Pharmacological properties
Vitamin B1 (thiamine) belongs to water-soluble vitamins. In the human body, as a result of phosphorylation processes, it turns into cocarboxylase, which is a coenzyme of many enzymatic reactions. Plays an important role in carbohydrate, protein and fat metabolism, in the processes of nerve excitation in synapses.

Indications for use
Hypovitaminosis and vitamin deficiency B1. In complex therapy: neuritis, radiculitis; neuralgia; peripheral paresis; paralysis; intestinal atony; myocardial dystrophy; violations of the coronary circulation; thyrotoxicosis; intestinal absorption disorders, endarteritis, psoriasis, eczema, intoxication.

Contraindications
Increased individual sensitivity.

Method of administration and dosage
The drug is used as directed by a doctor.
Thiamine solution 5% is administered intramuscularly. It is recommended to start the administration of the drug with low doses (no more than 0.5 ml of a 5% solution) and only with good tolerance to switch to higher doses.
Intramuscularly for adults, 0.05 g of thiamine (1 ml of 5% solution) once a day. The course of treatment is 10-30 injections.

Side effect
Allergic reactions (pruritus, urticaria, Quincke's edema, anaphylactic shock), sweating, tachycardia, and sometimes soreness at the injection site (due to low pH solutions) are possible.

Interaction with other medicinal products
Simultaneous parenteral administration of thiamine and pyridoxine (vitamin B6) or cyanocobalamin (vitamin B12) is not recommended. B12 enhances the allergenic effect of thiamine. B 6 makes it difficult to convert thiamine into a biologically active form. Vitamin B1 and penicillin or streptomycin (destruction of antibiotics), vitamin B1 and nicotinic acid (destruction of vitamin B1) should not be mixed in the same syringe.

Thiamine reduces the pharmacological activity of suxamethonium iodide, redergam, phentolamine, anaprilin, sympatholytics (reserpine, octadine), hypnotics (hypnotic and hypotensive effects are reduced).

The thiamine solution should not be mixed with solutions containing sulfites, because in them it completely disintegrates.

Release form
Ampoules of 1 ml. 10 ampoules in cardboard boxes.

Storage conditions
Store in a dark place. At temperatures Keep out of the reach of children.

Shelf life
3 years.
Do not use later than the date indicated on the package.

Conditions for dispensing from pharmacies.
Dispensed with a doctor's prescription.

Manufacturer's name and address
OJSC "Yerevan Chemical-Pharmaceutical Firm" Armenia 375040, Yerevan, Adjarian str. 2nd lane, 6.

Claim acceptance address:
LLC "StatusPharm"
109316, Moscow, Ostapovsky prospect, D. 5, building 1

The preparation contains an active substance thiamine .

An additional component can be water for injection.

Release form

Thiamine is available in the form of powder, capsules, tablets or a ready-made solution for injection. The substance is packaged in packages, vials or ampoules of 1 ml, 10 pieces per package.

pharmachologic effect

The drug has an effect that can compensate for the deficiency .

Pharmacodynamics and pharmacokinetics

Thiamine is a synthetic analogue of vitamin B1 with good water solubility. Inside the body, in the process of phosphorylation, the substance is converted into cocarboxylase - a coenzyme of most enzymatic reactions.

According to the pharmacopoeia, Thiamine Chloride, Thiamine Bromide, Tiamina Vial, Thiamine Hydrochloride- these are all trade names and analogues of vitamin B1. These drugs are offered as a white crystalline powder, capsule, tablet, or solution.

Usually they have a weak specific odor, dissolve well in water, show resistance to acidic solutions, but are easily destroyed under the influence of an alkaline and neutral environment.

Parenteral administration of drugs allows it to quickly penetrate into and evenly enough to be distributed inside the body.

Phosphorylation of the substance occurs in the area of ​​the liver. The accumulation of the vitamin is noted in the heart, liver, kidneys, brain and spleen. The main substance is excreted with the help of the liver and kidneys.

Vitamin B1 or Thiamin is necessary for complete carbohydrate, protein and fat metabolism, normal activity of the nervous, digestive, endocrine and cardiovascular systems.

Thiamine Mononitrate - what is it?

Thiamine Mononitrate has low hygroscopicity, but high resistance to external factors. Therefore, it is actively used in the process of fortification of various food products.

Indications for use

Thiamine is prescribed for:

• hypovitaminosis and vitamin deficiency B1;
• neuritis, radiculitis, peripheral paresis and paralysis, intestinal atony;
• fasting;
• chronic alcoholism;
• severe liver dysfunctions;
• increased need for at .

Contraindications for use

The main contraindication to taking the drug is hypersensitivity.

Side effects

When taking Thiamine, side effects may develop in the form of: sweating, , allergic reactions – , skin, anaphylactic shock.

Thiamin, application instruction (Way and dosage)

The instruction for the use of thiamine chloride informs that such a remedy can be prescribed for both internal and parenteral administration. The dosage is set by the doctor, but on average for adult patients it is 10 mg to be taken up to 5 times a day. For young patients under 3 years old, the recommended dose is 5 mg to be taken every other day, for children 3-8 years old - 5 mg 3 times a day every other day, from 8 years old - 10 mg 1-3 times a day. The duration of treatment is about 30 days.

The instruction for Thiamine hydrochloride recommends its use for deep intramuscular injection. For adult patients and children from 7 years of age, a daily dosage of 25-50 mg is prescribed. Treatment begins with the introduction of a small amount of solution. If the drug is well tolerated by patients, then the daily dosage is increased by 25 mg. In this case, the daily dose should not exceed 300 mg. The therapeutic course is 10-30 injections. Children under 3 months are prescribed 12.5 mg, from 4 months to 7 years - 25 mg to be taken once a day.

Overdose

In cases of overdose, it is possible to increase the severity of side effects. Therefore, the prescribed dose must be strictly observed.

Interaction

Simultaneous use with solutions that include sulfites and also, reduces their activity.

With simultaneous parenteral administration of Thiamin and or Cyanocobalamin possibly a significant increase in its action. In addition, it may complicate the conversion of Thiamine. It is forbidden to mix vitamin B1 with or, which can cause destruction and also with nicotinic acid capable of destroying vitamin B1.

Combination with suxamethonium iodide, Redergama, some sympatholytic for example: or Octadin - reduces their pharmacological action. The combination of Thiamine and hypnotics can reduce their hypnotic and hypotensive activity.

Terms of sale

Without recipe.

Storage conditions

Storing vitamin B1 requires a dark, cool place out of the reach of children.

Shelf life

Special instructions

What foods contain vitamin B1?

To prevent vitamin B1 deficiency, you need to include in your diet foods that contain this substance. Most of this component is found in buckwheat, oatmeal, peas, nuts and fatty pork. Thiamin is also found in bread made from coarse flour, wheat germ, rice bran, green vegetables, some berries and fruits.

A sufficient amount of the vitamin is present in wild and vegetable greens, algae, brewer's yeast, poultry, beef, liver, eggs and fish.

Application for hair of Thiamine chloride and its analogs

To strengthen hair, Thiamin Vial in ampoules is intended, which is not recommended for use in pure form, due to the possibility of development .

Thiamin Vial - what is it?

It should be noted that this drug is an analogue of vitamin B1. The condition of your hair can be noticeably improved by using this product with shampoo. Before each hair wash, you need to add only a few drops of the vitamin to the shampoo. The result is beautiful and manageable hair.

In addition, thiamine can be added to hair masks or balms, which greatly enhances their positive effect on quality and structure. A great way to strengthen your hair is to wrap it to make it healthier, more beautiful and shiny.

To do this, make a mixture of two teaspoons of castor or burdock oil, thiamine ampoules, ampoules , solution and lemon juice.

All this must be mixed well and rubbed into the hair roots. The rest of the remedy is to distribute along the length of the hair. Wrap your head in a towel and let stand for at least two hours. Then wash your hair well with shampoo. The procedure is recommended to be performed every other day for three weeks.

Analogs

Matching ATX level 4 code:

The main analogues of this drug: Vitamin B, Anevril, Anevrin, Benerva, Berin, Betabion, Benevrin, Betamine, Betanevrin, Betaxin, Betiamin, Bevital, Bevitin, Cristovibeks, Orizanin, Vitaplex Bi.

Also have a similar effect: , .

Alcohol

The simultaneous use of alcohol can significantly weaken the effect of vitamin B1 and accelerate its excretion from the body.

Thiamine hydrochloride (Vitamin B1)

International non-proprietary name

Dosage form

Solution for injection 5%, 1ml

Structure

1 ml of solution contains

active substance- thiamine hydrochloride 50.0 mg (in terms of 100% substance),

Excipients: unitiol, water for injection.

Description

Transparent, colorless or slightly colored liquid with a weak characteristic odor.

Pharmacotherapeutic group

Vitamins. Vitamin B1 and its combination with vitamins B6 and B12. Vitamin B1. Thiamin.

ATX code А11DA01

Pharmacological properties

Pharmacokinetics

Thiamine, when administered intramuscularly, is rapidly and completely absorbed. It is distributed fairly evenly over all organs and tissues. The relatively higher content of thiamine in the myocardium, skeletal muscles, nervous tissue and liver is associated with increased consumption of thiamine by these structures. It is metabolized in the liver and excreted by the kidneys, about 8-10% unchanged.

Pharmacodynamics

In the body, thiamine hydrochloride, due to phosphorylation processes, is converted into cocarboxylase, which is a coenzyme of many enzymatic reactions and plays an important role in carbohydrate, protein and lipid metabolism.

Thiamine hydrochloride, containing a quaternary nitrogen atom, affects the conduction of nervous excitation in synapses, has ganglion blocking and curariform effects.

Indications for use

Hypovitaminosis and vitamin B1 deficiency (including in patients on

tube feeding, hemodialysis, suffering from malabsorption syndrome)

Increased need for vitamin (during pregnancy and lactation)

As part of complex therapy:

Dystrophic processes (starvation, myocardial dystrophy, atony

intestines, severe liver dysfunction)

Diseases of the peripheral nervous system (neuritis, radiculitis, neuralgia, peripheral paresis or paralysis)

Skin lesions (dermatoses, lichen, psoriasis, eczema)

Intoxication (including chronic alcoholism, thyrotoxicosis).

Method of administration and dosage

Adults 50 mg of thiamine hydrochloride (1 ml of 5% solution) is injected intramuscularly once a day every day. It is recommended to start parenteral administration of thiamine with low doses (no more than 0.5 ml of a 5% solution) and only with good tolerance to switch to higher doses. (see more details in the chapter "Special instructions"). The course of treatment is usually 10-30 days, daily.

Children over 8 years old

injected at 12.5 mg (0.25 ml of 5% solution).

Side effects

Soreness at the injection site

Allergic reactions (Quincke's edema, urticaria, pruritus)

Bronchospastic syndrome with seizures, anaphylactic shock

Tachycardia, palpitations, collapse

Synaptoplegia - the ability of thiamine to form complexes with various mediators can be accompanied by a decrease in blood pressure, the occurrence of cardiac arrhythmias, impaired contraction of skeletal (including respiratory) muscles, and depression of the central nervous system; thiamine chloride contributes to the formation of staphylococcal resistance to antibiotics

Headache, dizziness, anxiety, paresthesia

Damage to the optic nerve

Shortness of breath, shortness of breath

Difficulty swallowing, nausea, intestinal hemorrhages

Hyperemia, itching

Violation of the activity of liver enzymes

- general disorders: increased sweating, chills, tremors, general weakness, edema, fever

Injection site reactions: rash, itching

Contraindications

Hypersensitivity to the drug and its components

Hypervitaminosis B1

Drug interactions

A solution of thiamine hydrochloride should not be mixed with solutions containing sulfites, because in them it completely disintegrates. Simultaneous parenteral administration of thiamine with pyridoxine or cyanocobalamin is not recommended: pyridoxine makes it difficult to convert thiamine into a biologically active form, cyanocobalamin enhances the allergenic effect of thiamine. Other vitamins (in particular, cyanocobalamin) can be inactivated in the presence of vitamin B1 breakdown products. Do not mix thiamine with benzylpenicillin or streptomycin (destruction of antibiotics), thiamine and nicotinic acid (destruction of thiamine) in the same syringe. Weakens the effect of depolarizing muscle relaxants (suxamethonium iodide, etc.). Thiamine is unstable in alkaline and neutral solutions; appointment with carbonates, citrates, barbiturates with Cu2 + is not recommended. When administered intramuscularly simultaneously with solutions containing sodium hydrosulfite as an antioxidant or preservative, thiamine is unstable. Ethanol slows down the rate of absorption of thiamine after oral administration.

special instructions

Allergic reactions and anaphylaxis often develop in persons prone to allergies, in women in the premenopausal and climacteric periods, and in those suffering from alcoholism.

If side effects occur, the drug should be taken

stop and consult your doctor.

Before parenteral use of thiamine chloride solution, it is necessary to carry out a skin test for individual sensitivity to the drug. After the injection, control is required for 30 minutes due to the possibility of severe allergic reactions.

Anaphylactic reactions develop more frequently after high-dose intravenous administration.

It is advisable to do thiamine injections no earlier than 12 hours after pyridoxine injection.

With intramuscular injection, the drug should be injected deep into the muscle, with intravenous injection - slowly.

Intramuscular and subcutaneous injections are painful due to the low pH of the solution.

The daily requirement for vitamin B1: for adult men - 1.2-2.1 mg, for the elderly - 1.2-1.4 mg, for women - 1.1-1.5 mg with the addition of 0.4 mg for pregnant women and 0.6 mg - for women during lactation, for children, depending on age, - 0.3-0.5 mg.

The drug should not be used as a substitute for a balanced diet, only in combination with diet therapy.

The injectable form of the drug should be used in the treatment of patients with intestinal absorption disorders or gastric resection, if it is impossible to take thiamine in tablet form (nausea, vomiting, pre- and postoperative period), as well as in severe forms of the disease or at the beginning of treatment for a faster achieving a therapeutic effect.

It is prescribed with caution in case of increased excitability of the nervous system, hyperacid forms of duodenal ulcer.

With Wernicke's encephalopathy, thiamine must be taken before glucose administration.

If an allergy to vitamin B1 is found, the patient is canceled rice, buckwheat, meat, bread (varieties baked from wholemeal flour).

In patients with alcoholism, the symptoms of side effects of the drug may increase. Thiamine can weaken the effect of depolarizing muscle relaxants, adrenolytic and sympathomimetic agents.

The drug (when taking high doses) can distort the results when determining theophylline in serum by the spectrophotometric method and urobilinogen using the Ehrlich reagent.

Pregnancy, lactation

It is possible to use the drug during pregnancy or lactation according to indications in recommended doses.

Children

For children, a 2.5% solution of thiamine chloride is usually used. It is allowed to administer a 5% solution to children over the age of 8 years.

Features of the influence of the drug on the ability to drive vehicles and especially dangerous mechanisms

During treatment, care should be taken when driving vehicles and working with complex mechanisms due to the possibility of side effects from the nervous system.

Overdose

Symptoms: it is possible to increase the symptoms of side effects of the drug. When used in large doses for a long time, signs of hyperthyroidism, headache, agitation, tremors, increased heart rate, and insomnia may appear.

Treatment: stop taking the drug, symptomatic therapy.

Release form and packaging

1 ml in neutral glass ampoules or sterile ampoules for syringe filling.

Each ampoule is labeled with label paper or the text is applied directly to the ampoule with intaglio ink for glass products.

10 ampoules are placed in a cardboard box. An ampoule scarifier is placed in each box.

When packing ampoules with notches, rings and dots, the scarifier is not inserted.

5 or 10 ampoules are packed in a blister strip made of polyvinyl chloride film and aluminum foil.

2 contour packs of 5 ampoules, together with the approved instructions for medical use in the state and Russian languages, are put into a carton pack. An ampoule scarifier is placed in each pack. When packing ampoules with notches, rings and dots, scarifiers are not inserted.

Contour packages of 5 or 10 ampoules are placed in cardboard boxes. Each box contains approved instructions for medical use in the state and Russian languages ​​according to the number of packages.

Storage conditions

Store in a dry, dark place at a temperature not exceeding 30 ° C.

Keep out of the reach of children!

Shelf life

Do not use after the expiration date.

Conditions of dispensing from pharmacies

On prescription

Manufacturer

JSC "Khimfarm", Republic of Kazakhstan,

Shymkent, st. Rashidova, 81, t / f: 560882

Marketing Authorization Holder

JSC "Khimfarm", Republic of Kazakhstan

The address of the organization that accepts claims from consumers on the quality of products (goods) on the territory of the Republic of Kazakhstan

JSC "Khimfarm", Shymkent, Republic of Kazakhstan,

st. Rashidova, 81, t / f: 560882

Phone number 7252 (561342)

Fax number 7252 (561342)

E-mail address [email protected]