This article allows you to familiarize yourself with the instructions for the use of the drug. Amosic. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists in the use of antibiotic amosine in their practice. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effects, possibly not stated by the manufacturer in annotations. Amone analogues in the presence of available structural analogs. Use for the treatment of angina, pneumonia, hymorite and other infectious diseases in adults, children, as well as during pregnancy and breastfeeding. The composition and interaction of the drug with alcohol.

Amosic - antibiotic wide range of a group of semi-synthetic penicillins. Acts bactericidal. Inhibits transpapeptide, disrupts peptideoglycan synthesis (the support polymer of the cell wall) during the division and growth period, causes lysis bacteria. Acid-resistant.

Active in relation to aerobic gram-positive bacteria: Staphylococcus SPP. (Staphylococcus) (with the exception of penicillinase strains), Streptococcus SPP. (streptococcus); Aerobic gram-negative bacteria: Neisseria Gonorrhoeae, Neisseria Meningitidis, Bacillus Anthracis, Listeria Monocytogenes (Listeria), Helicobacter Pylori (Helicobacter), Klebsiella SPP. (Klebseyella).

Microorganisms producing penicillinase, resistant to the action of amoxicillin.

The action is developing 15-30 minutes after administration and lasts 8 hours.

Structure

Amoxicillin (in the form of trihydrate) + excipients.

Pharmacokinetics

After receiving inside Amosin quickly and almost completely (93%) absorbed from the gastrointestinal tract. Meal does not affect the absorption of the drug, does not destroy in the acidic area of \u200b\u200bthe stomach. In high concentrations, plasma, wet, bronchial secrete (in the purulent bronchial secrete, the distribution of weak), pleural and peritoneal fluid, urine, the contents of the skin blisters, the tissue of the lung, mucous membrane of the intestine, the female genital organs, the prostate gland, the liquid of the middle ear, bone , adipose tissue, bustling bubble (with normal liver function), fetal tissues. With an increase in the dose of 2 times the concentration also increases by 2 times. The concentration in bile exceeds the plasma concentration of 2-4 times. In amniotic fluid and umbilical vessels, amoxicillin concentration - 25-30% of the plasma level in a pregnant woman. Poor penetrates through the hematostephalic barrier (BEB), with inflammation of brain shells (meningitis), a concentration in the spinal fluid is about 20%. Binding with plasma proteins - 17%. In small quantities stands out with breast milk. Amoxicillin is partially metabolized with the formation of inactive metabolites. Amoxicillin is excreted by 50-70% with urine unchanged by canalic excretion (80%) and glomerular filtration (20%), with bile - 10-20%.

Indications

Infectious-inflammatory diseases caused by microorganisms sensitive to the drug:

• respiratory infections (including bronchitis, pneumonia);
• eNT infections (including sinusitis, pharyngitis, tonsillitis, acute average otitis);
• infections of the urogenital system (including pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea);
• gynecological infections (including endometritis, cervicitis);
• infections of the gastrointestinal organs (including peritonitis, enterocolitis, abdominal typhoid, cholangitis, cholecystitis);
• infections of the skin and soft tissues (including face, impetigo, secondally infected dermatoses);
• leptospirosis;
• listeriosis;
• lyme disease (borreliosis);
• dysentery;
• salmonellosis, salmoneselosis;
• meningitis;
• endocarditis (prevention);
• sepsis.

Forms of release

250 mg capsules.

Tablets 250 mg and 500 mg.

Powder for preparing a suspension for intake of 125 mg, 250 mg and 500 mg.

Instructions for use and dosage

The drug is taken inward, before or after meals. The dosing mode is established individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.

Adults and children over 10 years old (with a mass of body more than 40 kg) are appointed 500 mg 3 times a day, with a serious course of the disease - at 0.75-1 g 3 times a day.

Children aged from 5 to 10 years are prescribed 250 mg 3 times a day, aged 2 to 5 years - 125 mg 3 times a day, under the age of 2 years - 20 mg / kg per day in 3 reception. Course treatment - 5-12 days.

Children at the age of 5 years old the drug is prescribed in the form of a suspension (the ideal children's form of the drug).

For the treatment of acute uncomplicated gonorrhea, the drug is prescribed in a dose of 3 g once; In the treatment of women, it is recommended to repeat the specified dose.

With acute infectious diseases of the gastrointestinal tract (paratyphids, typhoids) and biliary tract, with gynecological infectious diseases, adults are prescribed 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

When leptospirosis, adults are prescribed at 500-750 mg 4 times a day for 6-12 days.

At silmosenelease adults - 1.5-2 g 3 times a day for 2-4 weeks.

For the prevention of endocarditis at small surgical interventions, adults are prescribed at a dose of 3-4 g per 1 hour before the procedure. If necessary, prescribe a re-dose after 8-9 hours. Children dose are doubled.

Rules for the preparation of suspension from a monocot package

The pure glass poured a boiled and cooled water in the amount specified in the table, then the contents of one package are poured and stirred to obtain a homogeneous suspension.

• Dose in package 125 mg - the required amount of water 2.5 ml;
• dose in package 250 mg - the required amount of water is 5 ml;
• dose in package of 500 mg is the required amount of water 10 ml.

After receiving the cup, rinse with water, dry and store in a dry, clean place.

Side effect

• hives;
• skin hyperemia;
• erythema;
• angioedema edema;
• rhinitis;
• conjunctivitis;
• fever;
• pain in the joints;
• eosinophilia;
• exfoliative dermatitis;
• multiform exudative erythema;
• stevens-Johnson syndrome;
• reactions similar to serum disease;
• anaphylactic shock;
• dysbacteriosis;
• a change in taste;
• vomiting, nausea;
• diarrhea;
• stomatitis;
• glossitis;
• pseudomambranous enterocolitis;
• excitation;
• anxiety;
• insomnia;
• confusion of consciousness;
• change behavior;
• depression;
• peripheral neuropathy;
• headache;
• dizziness;
• convulsive reactions;
• interstitial nephritis;
• leukopenia, neutropenia, thrombocytopenic purpura, anemia;
• labored breathing;
• tachycardia;
• candidiasis of the vagina;
• superinfection (especially in patients with chronic diseases or reduced organism resistance).

Contraindications

• allergic diathesis;
• bronchial asthma, pollinosis;
• infectious mononucleosis;
• lympholoicosis;
• liver failure;
• the diseases of the gastrointestinal tract (especially colitis associated with the use of antibiotics);
• lactation period (breastfeeding);
• increased sensitivity to the components of the drug;
• increased sensitivity to other penicillins, cephalosporins, carbapenes;
• children's age up to 3 years (for tablets and capsules).

Application in pregnancy and breastfeeding

The use of the drug during pregnancy is possible only in cases where the intended benefit of therapy for the mother exceeds the potential risk to the fetus.

Application during lactation is contraindicated. If necessary, use during lactation should be stopped breastfeeding.

Application in children

Contraindicated children under the age of 3 years (for the form of release in the form of tablets and capsules). Children at the age of 5 years old are prescribed in the form of a suspension.

special instructions

When conducting a course of treatment with amoSin, it is necessary to monitor the state of the function of the blood formation organs, liver and kidney.

It is possible to develop superinfection due to the growth of microflora insensitive to amoxicillin, which requires an appropriate change in antibacterial therapy.

In the treatment of patients with bacteremia, the reaction of bacteriolization is rarely developed (Yarish-Gersheimer's reaction).

In patients having increased sensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

In the treatment of light diarrhea, against the background of the use of amosine, the appointment of antiodeary drugs, which reduce the intestinal peristalsis should be avoided; Can be used kaolin- or attapulgite-containing anti-diagracial agents. With severe diarrhea, it is necessary to carry out differential diagnostics and assign appropriate therapy.

Treatment should be continued 48-72 hours after the disappearance of clinical signs of the disease.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, if possible, use additional methods of contraception.

Medicinal interaction

Antacids, glucosamine, laxatives, food, antibiotics of aminoglycoside groups, while simultaneous use, slow down and reduce amosine absorption; Ascorbic acid - increases its absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) exhibit synergism with amoxicillin; Bacteriostatic preparations (macrolides, chloramphenicol, lincoosamines, tetracyclines, sulfonamides) - antagonism.

Amoxicillin, while simultaneously use, increases the efficiency of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); Reduces the effectiveness of estrogen-containing oral contraceptives, ethinyl estradiol (the risk of intermented bleeding), as well as drugs, in the process of metabolism of which para-aminobenzoic acid is formed.

The joint use of the drug amosyn with alcohol is prohibited (the hepatotoxic effect of ethanol is enhanced).

Diuretics, Allopurinol, Oxyphenbutazone, phenylbutazone, nonsteroidal anti-inflammatory agents (NSAIDs) and drugs that block the tubular secretion, while simultaneously use with amosine, reducing the channel secretion, increase the concentration of amoxicillin.

With the simultaneous use of amosine with allopurinol, the risk of skin rash is increased.

Amoxicillin, while simultaneously use, reduces the clearance and increases the toxicity of methotrexate.

Amoxicillin with simultaneous use enhances the absorption of digoxin.

Analogs of the Medicinal Amosin

Structural analogues for the acting substance:

• Amoxisar;
• Amoxicillin;
• Amoxicillin trihydrate;
• Gonoform;
• Grunamox;
• Danemoks;
• OSPAMOKS;
• Flexin Soluteab;
• Hikcotil;
• Ecobol.

In the absence of analogues of drugs on the active substance, you can follow the links below on the disease, which helps the appropriate drug, and see the analogues on therapeutic effects.

Infectious diseases are known to be sufficiently dangerous and cunning. And the most unpleasant is the complications that they are capable of calling. The causes of infectious pathologies are hidden in the penetration of malicious bacteria into the body. Courish the patient only with antibiotics. One of these drugs is the AMOSIN Cure 500 mg. Instructions for use will allow to study in more detail this means.

Drug Description

So, consider how the AMOSIN medication is positioned for use (indications, form of release). The medicine is the distinctive characteristic of the medication - this is a wide range of exposure and high bactericidal effect.

The antibiotic is able to fight with many gram-negative and gram-positive microorganisms:

• streptococci;
• staphylococci;
• klebseyella;
• salmonella;
• helicobacter pylori;
• gonococci;
• sheets;
• the causative agents of meningitis, Siberian ulcers.

The "Amosin" medicine inhibits the synthesis of substances that are the basis of the cell membranes. As a result, their integrity is broken. This leads to the death of bacteria.

As evidenced by the AMOSIN (500 mg) applied for use, the drug has an impact on the body after 15-30 minutes, after its use. A favorable effect is preserved for 8 hours.

The medication, falling into the body, quickly and almost fully absorbed into the gastrointestinal tract. The active ingredient drug is not only in the blood. It penetrates into the mucous membranes, bone tissues, organs, liquids.

Forms of release

The main active substance of the medication is amoxicillin. It is precisely it that provides therapeutic effects on the body. So approves the instructions applied to the preparation "AMOSIN".

The form of release of the medication allows you to choose the necessary medicine for any category of patients.

After all, the drug is produced:

1. Tablets. In appearance, it is white shadt pills, flat-cylindrical. They may contain an active substance in quantity: 250 mg, 500 mg.
2. Capsules These are gelatin containers, white. They contain white granules. The dosage of the active substance is 250 mg.
3. Powder. It is intended for self-making suspension. Powder has a slightly yellowish tint. It has a specific smell. Making suspension retains aroma and yellowish tint. A medication is produced in several dosages: 125, 250, 500 mg.

Indications for use

The medicine is recommended for use with various bacterial infections that provoked by a sensitive microflora. The drug "Amosin" 500 mg Instructions for use advises to use with multiple respiratory tract infections, skin cover, urogenital system.

The main indications for the purpose of the medication are:

• diseases of the respiratory organs (bronchitis, pneumonia);
• the pathology of the ENT organs (tonsillitis, sinusitis, pharyngitis, middle Otitis);
• ailments of the urogenital system (pyelonephritis, urethritis, gonorrhea, pyelitis, cystitis);
• gynecological infections (endometritis, cervicitis);
• disease gastrointestinal diseases (peritonitis, enterocolitis, cholangitis, cholecystitis);
• pathology of soft tissues and skin (Ryg, Impochigo, Dermatoz);
• listeriosis;
• leptospirosis;
• borreliosis (Lyme disease);
• dysentery;
• meningitis;
• salmonellosis;
• endocarditis (in preventive purposes);
• sepsis.

How advises the drug "Amosin" instructions for use (in tablets and in capsules)?

The abstract of the medication provides the following recommendations:

1. In any form, intended for oral administration "Amosin".
2. Capsules Instructions for use advises not to chew and grind. They should be consumed before or after meals.
3. "AMOSIN 500" (Tablets) Instructions for use recommends to be taken regardless of food. Pills are allowed to grind, divide into parts.
4. Take medicine at identical intervals.
5. The recommended course of therapy with this tool defines only the doctor.
6. Adults and children from 10 years old, if the mass mass of the latter is above 40 kg, is prescribed 500 mg of medication 3 times a day.
7. If pathology proceeds in severe, the doctor may recommend a higher dose of the drug. In this case, the patient is prescribed 3 times a day to take 750 -1000 mg.
8. How recommends AMOSIN medication taking instructions for use (in tablets for children from 5 to 10 years)? Such patients are scheduled 3 times a day to use 250 mg.
9. On average, the duration of treatment is 5-12 days.

Specific treatment schemes

Dosages of medicine may vary depending on the pathology. It is necessary to take into account the condition of the patient and age, and weight. That is why it is important that the specialist picked up the treatment scheme. Consider how I am recommended to take the AMOSIN drug instruction. In tablets or capsules is not important.

The following schemes are shown:

1. Under the acute stage of gonorrhea, the patient is prescribed to once adopt 3000 mg of medication. For women, repeated medication can be recommended in the same dosage.
2. It is recommended to use 1500-2000 mg 3 times a day to treat diseases of the tract and gynecological ailments 3 times a day. Another therapy scheme can be assigned. In this case, the patient follows 4 times a day to use 1000-1500 mg.
3. Leptospirosis is heal with a reception of 500-750 mg of medication. The multiplicity of drug use is 4 times a day. Appoint such treatment for 6-12 days.
4. If salmoneselosis is revealed, it was recommended to use 1500-2000 mg to use 3 times a day. According to such a scheme, the drug is used 2-4 weeks.
5. For the prevention of endocarditis, as well as in the case of surgical operations, the patient is prescribed in 1 hour before the intervention intake at a dose of 3000-4000 mg.
6. Re-receiving medication is possible only after 8-9 hours after the first dose.
7. People who have revealed impaired kidney function, the doctor will reduce the multiplicity of drug intake. At the same time, the dosages of the medication are preserved.
8. The maximum dose for the patients of Anuria is 2000 mg.

Features of powder reception

The powder is used as follows:

1. The drug is intended as described above, for the manufacture of suspension.
2. To prepare the solution, it is necessary to pour boiled water (chilled) in the amount of 10 ml. It poured the contents of the bag (500 mg of powder). Stir until the formation of a homogeneous suspension. If you use a preparation containing 125 mg of the active substance, then the fluid will need 2.5 ml. For 250 mg of water powder take 5 ml.
3. Suspension is accepted immediately after cooking.
4. If you use the drug, packaged in vials or banks, then the contents are necessary to pour with water in an amount of 62 ml. Shake the container vigorously until the medication is completely dissolved. The prepared suspension contains in 1 ml of 50 mg of amoxicillin.
5. Adults are recommended 300 mg of medication 3 times a day. A single dosage corresponds to 1 packet of powder.

Treatment of kids

The following rules are recorded in the annotation of the medication:

1. Patients over 10 years old, with a mass mass of more than 40 kg, it is recommended to apply the medicine as well as adult people. It is assigned 300 mg of medication 3 times a day.
2. For guys from 5 to 10 years, it is better to use tablets containing 250 mg of amoxicillin or powder in the same dosage. Such kids are recommended 3 times a day to use 1 pill (250 mg) or to breed 1 packet medication.
3. Toddlesham 2-5 years are prescribed three times a day to take 125 mg.
4. For up to 2 years old, the dosage is calculated, given the body weight - 20 mg / kg.

Side effects

During medication treatment, unwanted reactions may occur. This warns the instructions for use attached to the Preparation of "Amosin".

Tablets (500mg), capsules and powder are able to provoke problems from a row of systems. It:

1. The gastrointestinal tract and against the background of therapy may appear: dysbacteriosis, diarrhea, vomiting, violation of taste. Sometimes the occurrence of glossite, stomatitis, nausea, in some cases there is an increase in the activity of hepatic enzymes.
2. Blood system. Patients may encounter neutropenia. Sometimes the medication provokes leukopenia, anemia,
3. Nervous system. Patients may complain to the appearance of excitement, increased anxiety, disturbed sleep. Some patients have a confusion confusion, ataxia, the emergence of depression, change behavior. Headache, peripheral neuropathy, convulsions, dizziness may develop.
4. Allergic reactions. Therapy of this means sometimes leads to the appearance of itching, rash, hyperemia of covers, urticaria, erythema, some patients may appear allergic conjunctivitis, rhinitis. There are cases when the medication caused anaphylactic shock and reactions resembling

In addition to the above negative features, may appear:

• labored breathing;
• arthralgia;
• interstitial nephritis;
• candadose vaginitis;
• tachycardia;
• superinfection.

In the case of such symptoms, consult a doctor. It will cancel the drug and selects another tool for treating.

Contraindications

Medication can not be taken with such a littleness as:

• allergic diathesis;
• pollnosis;
• lympholoicosis;
• lactation period;
• poland aells in history;
• infectious mononucleosis;
• liver failure;
• increased sensitivity;
• bronchial asthma;
• children's age, under 3 years old (this applies to tablets, capsules).

Some patients sometimes have a question about whether it is possible to combine alcohol-containing drinks with the Amosin medicine (500 mg). Instructions for use and alcohol are important moments to pay attention to. The use of alcohol-containing beverages during treatment with the drug is prohibited.

In addition, activities related to the high concentration of attention should be limited.

Very careful medication can be appointed pregnant women, patients with renal failure. Special attention requires patients who had bleeding in history.

Symptoms overdose

In the case of a patient with high doses of medication, the following features may develop:

• diarrhea;
• vomiting, nausea;
• broken water and electrolyte balance;
• abdominal pain.

Specific antidote to this medicine does not exist. Therefore, in the event of an overdose, symptomatic therapy is being taken. Initially, the patient was washed with a stomach. The patient shows the use of enterosorbent drugs.

It is important to protect the body from the water and electrolyte violation. To do this, the patient recommends activities aimed at maintaining balance in the body. Salt laxatives are also prescribed.

To reduce the concentration of amoxicillin in plasma, the doctor may recommend hemodialysis.

Analogs of the drug

Replace the original agent by other, no less effective, medicines. However, remember that only your attending physician can assign or cancel antibiotics.

Treatments-analogues:

• "FLEXIN SOLUTAB";
• "Ekobol";
• "Amoxiciline";
• "Amoxesar";
• "Hikcotsil";
• "Gonoform";
• "OSPAMOK";
• "Danemoks";
• "Grünamoks".

Opinions about the medicine

It is described above, as the Amosic medication (500 mg) is positioned. Feedback people who took the drug are of great interest. Therefore, we consider what the patients say about the medicine.

Opinions about the preparation are low enough. Some people claim that they had been appointed medicine at heavy stages of ailments, such as bronchitis, pneumonia, Middle Otitis with complications. Such patients indicate that the Amosin preparation helps them helps them from serious pathologies. At the same time, they argue that improving the state happened literally after a couple of days. Propying the medicine on the scheme appointed by the doctor, they completely restored the body. In this case, the side effects did not arise.

Another category of people is somewhat different opinions. They argue that the antibiotic has begun without the appointment of a doctor. Therapeutic effects they managed to achieve - the ailment retreated. But after therapy, some consequences arose. Mostly patients complain about the appearance of dysbiosis. Such a category of people had to fight for a long time with the negative consequences of independent treatment.

And of course, there are feedback, testifying that the preparation of the drug in the first days provoked the development of side effects. Such people are not taken to approve the effectiveness of the fund, but they focus on the fact that the medication can become a source of appearance of sufficiently unpleasant symptoms.

One tablet contains

active substance - amoxicillin trihydrate (in terms of amoxicillin) 250 mg, 500 mg,

auxiliary substances: Potato starch, magnesium stearate, talc, povedium, calcium stearate.

Description

Pills of white or almost white color, flat-cylindrical from the face and risk.

Pharmacotherapeutic group

Antibacterial drugs for system use. Beta-lactam antibacterial drugs - penicillins. Penicillins of a wide range of action. Amoxicillin

Code ATH J01CA04.

Pharmacological properties

Pharmacokinetics

Absorption is fast, high (93%), food intake does not affect absorption, does not destroy in the acidic area of \u200b\u200bthe stomach. When taking inside at a dose of 125 and 250 mg, the maximum concentration is 1.5-3 and 3.5-5 μg / ml, respectively. The time to achieve maximum concentration after oral administration is 1-2 hours.

It has a large amount of distribution: in high concentrations are found in plasma, sputum, bronchial secrecy (in the purulent bronchial secrete, the distribution of weak), pleural and peritoneal fluid, urine, the contents of the skin blisters, the tissue of the lung, intestinal mucosa, female genital organs, prostate gland, Middle Ear liquids (with inflammation), bones, adipose tissue, bustling bubble (with normal liver function), fetal tissues. With an increase in the dose of 2 times the concentration also increases by 2 times.

The concentration in bile exceeds the plasma concentration of 2-4 times. In amniotic fluid and umbilical vessels, amoxicillin concentration - 25-30% of the level in the plasma of a pregnant woman. It penetrates poorly through the hematorecephalic barrier, but with inflammation of the brain shells, the concentration in the cerebrospinal fluid is about 20% of the plasma level. Communication with plasma proteins - 17%. Partially metabolized with the formation of inactive metabolites. The half-life period is 1-1.5 hours. Is excreted by 50-70% by the kidneys unchanged (by the tubular secretion - 80% and glomerular filtration - 20%), liver - 10-20%. In small quantities stands out with breast milk. In disruption of the kidney function (Creatinine clearance (CC) less than or equal to 15 ml / min), the half-life increases to 8.5 hours.

Amoxicilline is removed during hemodialysis.

Pharmacodynamics

Amosin® is a bactericidal antibiotic of a wide range of action from a group of semi-synthetic penicillins. The synthesis of peptidoglycan (supporting polymer of the cell wall) dislocation and growth, causes lysis bacteria.

Active in relation to: aerobic gram-positive microorganisms: Staphylococcus SPP. (With the exception of penicillinase strains), Streptococcus SPP. and aerobic gram-negative microorganisms: Neisseria Gonorrhoeae, Neisseria Meningitidis, Escherichia Coli, Shigella SPP., Salmonella SPP., Klebsiella SPP. Penicillinase strains, resistant to amoxicillin action.

Indications for use

Bronchitis, pneumonia
- sinusitis, pharyngitis, tonsillitis, acute middle otitis
- Pyelonephritis, Pelitis, Custitis, Urertrit, Gonorrhea, Endometrite, Cervicitis
- cholegitis, cholecystitis, dysentery, salmonellosis, salinelose
- Rozh, Impochigo, Secondary infected dermatoses
- Leptospyros
- Liseriosis
- Lyme disease (borreliosis)
- Endocarditis (prevention)

Method of application and dose

Inside, accepted independently of meals. A tablet can be swallowed entirely, divided into parts or dear, picking a glass of water.

Adults and children old

she is 10 years old (with a mass of the body more than 40 kg) are prescribed 500 mg 3 times a day; In case of severe infection - 750-1000 mg 3 times a day.

Children at the age of 6-10 years are prescribed 250 mg 3 times a day; In case of severe infection - 60 mg / kg / day 3 times a day. Course of treatment 5-12 days.
With acute uncomplicated gonor, 3000 mg is prescribed once; In the treatment of women, it is recommended to repeat the specified dose in a day.
With acute infectious diseases of the gastrointestinal tract (parathy, abdominal typhoid) and biliary tract, with gynecological infectious diseases adults - 1500-2000 mg 3 times a day or 1000-1500 mg 4 times a day.
When leptospirosis adults - 500-750 mg 4 times a day for 6-12 days.
At silmoseneclicity adults - 1500-2000 mg 3 times a day for 2-4 weeks.
For the prevention of endocarditis at small surgical interventions of adults - 3000-4000 mg per 1 hour before the procedure. If necessary, prescribe a re-dose after 8-9 hours. Children re-dose reduce 2 times.
In patients with impaired kidney function at QC 15-40 ml / min, the interval between receptions increases to 12 hours; At QC below, 10 ml / min dose is reduced by 15-50%; With anouria - the maximum dose of 2000 mg / day.

Side effects

Dysbacteriosis, change in taste, stomatitis, glossite, vomiting, nausea, diarrhea, moderate increase in the activity of "liver" transaminase

Pseudommbranous enterocolit

Excitation, anxiety, insomnia, ataxia, confusion of consciousness, change behavior, depression, peripheral neuropathy, headache, dizziness, epileptic reactions

Leukopenia, neutropenia, thrombocytopenic purpura, anemia

Urticaria, skin hyperemia, erythematous rashes, angioedema edema, rhinitis, conjunctivitis; Rarely - fever, arthralga, eosinophilia, exfoliative dermatitis, multiform exudative erythema (incl. Stevens-Johnson syndrome), reactions similar to serum disease, very rarely - anaphylactic shock

Others: Vaginal candidation, difficulty breathing, tachycardia, interstitial nephritis, superinfection (especially in patients with chronic diseases or reduced organism resistance)

Contraindications

Hypersensitivity to the drug (including to other penicillins, cephalosporins, carbapenes)

Children's age up to 6 years (for this dosage form)

Period lactation

Medicinal interactions

Antacids, glucosamine, laxative drugs, food, aminoglycosides slow down and reduce absorption; Ascorbic acid increases absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) have a synergistic effect; Bacteriostatic drugs (macrolides, chloramphenicol, lincoosamides, tetracyclines, sulfonamides) - antagonistic.

Increases the efficiency of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives; Drugs, in the process of metabolism of which a para-aminobenzoic acid is formed, ethinyl estradiol - the risk of "breakthrough" bleeding.

Amoxicillin reduces clearance and increases the toxicity of methotrexate; Enhances the absorption of digoxin.

Diuretics, Allopurinol, Oxyphenbutayon, phenylbutazone, non-steroidal anti-inflammatory preparations, and other drugs that block the tubular secretion increase the concentration of amoxicillin in the blood.

Allopurinol increases the risk of skin rash.

special instructions

With caution: allergic diseases (including history), diseases of the gastrointestinal tract in history (especially colitis associated with the use of antibiotics), renal failure, severe disorders of the liver function, infectious mononucleosis, lympholoicosis.

In case treatment, it is necessary to monitor the condition of the function of the blood formation organs, liver and kidneys.

It is possible to develop superinfection due to the growth of microflora insensitive to it, which requires an appropriate change in antibacterial therapy.

When prescribing patients with sepsis, the reaction of bacteriolization is possible (Yarish-Gersheimer's reaction) (rarely).

In patients having increased sensitivity to penicillins, cross-allergic reactions with other beta-lactam antibiotics are possible.

In the treatment of light diarrhea, against the backdrop of course treatment, antidiaryaric drugs that reduce the intestinal peristalsis should be avoided; Can be used kaolin- or attapulgite-containing anti-diagracial agents.

With severe diarrhea, it is necessary to consult a doctor.

Treatment necessarily continues 48-72 hours after the disappearance of clinical signs of the disease.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, if possible, use other or additional methods of contraception.

AMOSIN is one of the most effective antimicrobial drugs that show activity in relation to both gram-negative and gram-positive microorganisms. The main component of this drug is a semi-synthetic antibiotic related to the penicillin group - amoxicillin. It is due to its presence in the composition of this medicine, it can have a pronounced bactericidal effect, Amosin from which is used to treat a wide range of diseases. So what is the mechanism of action of this medical drug? When and how should it be taken? You will learn about this and many other things from this article.

The bactericidal activity of amosine is manifested in the ability to suppress such malicious microorganisms, like Shigella, staphylococci, streptococci, salmonella, intestinal wand, sepsis, mining pathogen and others. Finding into the human body, the drug oppressively affects the synthesis of peptidoglycan - a special substance, which is the basis of the bacterial membrane. As a result, the integrity of the outer shell of microorganisms is broken, and they die. The maximum activity of the main active component of the medication is observed in approximately 1 - 2 hours after its reception, the A amosyn medication from which differs from other drugs with a lightning effect.

Amosin from what helps?

This drug is used for the therapeutic treatment of patients suffering from diseases of the lower and upper respiratory tract, as well as the ENT organs. It will be effective if you are susceptible to amoxicillin-sensitive bacteria. As a rule, doctors prescribe this tool when cystitis, sinusitis, otitis, pneumonia and tonsillitis. Medical professionals also recommend this medicine to patients suffering from the diseases of the genitourinary system of bacterial etiology: ureterite, gonorrhea, cervicitis, pyelitis, endometritis.
Amosin is a popular medicine used for drug therapy patients with gastrointestinal pathologies. It is effective in dysentery, cholecystitis, salmonellosis, etc. Moreover, it helps with various infectious lesions of the skin and soft tissues, is prescribed as a prophylactic agent to prevent endocarditis development.

Rules for reception and dosage

The dosage of this drug depends on the age of the patient, the individual characteristics of its organism and other nuances. Therefore, it is imperative to understand that the most effective medical drug you can appoint only a doctor based on own observations and surveys.
Amosin should be taken inside regardless of the time of food, drinking with plenty of liquid. Adults and children whose age overcame a mark of 10 years, this drug is recommended to use 0.5 grams 3 times a day. In the case of very severe infectious diseases, the dosage can be increased for 0, 75 - 1 gram per day. For children under 10 years of Amosin, it is better to give a suspension in the form of a suspension between 5 to 10 years - 0, 25 ml., Aged 2 to 5 years - 0, 125 ml. If the child has an infection very hard, then 60 ml is prescribed. 3 times a day.
With acute gonor, this medicine should be taken 3 grams 2 times a day. In case of infectious diseases of the gastrointestinal tract, it is necessary to drink 1.5 - 2 grams per day. The average duration of such treatment is 5 - 12 days.
Contraindications for use:

1. This medicine can not drink people with hypersensitivity to amoxicillin.
2. Amosin is not appointed to small children whose age is less than 3 years.
3. Doctors do not recommend using this medication for drug therapy of people suffering from additionally bronchial asthma, polynosis, mononucleosis, allergic diathesis, and those who have identified violations of the liver and kidney function.
4. It is impossible to give Amosin to people with severe diseases of the digestive tract, bleeding.

Amosin is an effective drug with antimicrobial action. It is prescribed with a variety of diseases that were caused by the vital activity of malicious microorganisms. Despite the fact that this drug is a popular and demanded medicine, it should be made strictly according to the instructions. It can adversely affect the still inconscable kid's body, Amosin from which the tablet is better not to use during pregnancy and lactation. Be healthy!

Instruction

for medical use of the drug

Amosin ®.

Tradename

Amosin ®.

International non-proprietary title

Amoxicillin

Dosage form

P orcool for the preparation of a suspension for intake, 125 mg, 250 mg and 500 mg

Structure

One package contains

active substance - amoxicillin trihydrate 125 mg, 250 mg and 500 mg (in terms of amoxicillin),

excipients: Povidone, Dextrose, Dinatariya Edatat, sodium hydrophosphate, sodium α-glutamin 1-water, Food flavoring, vanillin, sucrose

Description

White powder with a yellowish color shade, with a specific smell. The finished suspension is a white suspension with a yellowish colors, with a specific smell.

Pharmacotherapeutic group

Antibacterial drugs for system use. Beta-lactam antibacterial drugs - penicillins. Penicillins of a wide range of action. Amoxicillin.

ATH code J 01CA04

Pharmacological properties

Pharmacokinetics

Suction

The absolute bioavailability of amoxicillin depends on the dose and mode of administration and is in the range from 75 to 90%. In doses of 250 mg to 750 mg bioavailability (parameters:AUC and / or selection with urine) linearly proportional to the dose. In higher doses, the suction is lower. Meal does not affect suction. Amoxicillin is acid resistant. Under the oral one-time reception at a dose of 500 mg, the concentration of amoxicillin in the blood is 6-11 mg / l. After one-time reception 3 g of amoxicillin, the concentration in the blood reaches 27 mg / l. The maximum concentrations in the blood plasma are observed after 1 - 2 hours after the preparation of the drug.

Distribution

About 17% of amoxicillin is located in the plasma proteins associated with proteins. The therapeutic concentration of the drug is rapidly achieved in plasma, lungs, bronchial secrete, medium ear liquid, bile and urine. Amoxicillin can penetrate through the inflamed brain shells in the cerebrospinal fluid. Amoxicillin passes through the placenta and in small quantities is found in breast milk.

Biotransformation and elimination

The main place of removal of amoxicillin is kidney. About 60-80% of the oral dose of amoxicillin is released within 6 hours after taking in an unchanged active form through the kidneys and a small fraction is excreted in bile. Approximately 7 - 25% of the dose is metabolized to inactive penicillane acid. The half-life of blood plasma in patients with unchanged kidney function is 1 - 1.5 hours. In patients with severe renal failure, the half-life varies from 5 to 20 hours. Amoxicillin is hemodialysis.

Pharmacodynamics

Antibacterial bactericidic acid-resistant preparation of a wide range of action from a group of semi-synthetic penicillins. Inhibits transpeptide, disrupts peptidoglycan synthesis (cell wall support protein) during the division and growth period, causes lysis bacteria.

Active in relation to aerobic gram-positive bacteria:Staphylococcus SPP. . (with the exception of penicillinase strains),Streptococcus SPP. ; and aerobic gram-negative bacteria: Neisseria Gonorrhoeae, Neisseria Meningitidis, Escherichia Coli, Shigella SPP., Salmonella SPP., Klebsiella SPP. Microorganisms producing penicillinase, resistant to the action of amoxicillin. The action is developing 15-30 minutes after administration and lasts 8 hours.

Indications for use

Treatment of infectious inflammatory diseases caused by microorganisms sensitive to the drug:

Infections of the upper respiratory tract, including ear infections, nose and throat: acute average otitis, acute sinusitis, tonsillitis, bacterial pharyngitis

Infectilation of the lower respiratory tract: aggravation of chronic bronchitis, community-hospital pneumonia

Infectilation of the lower urinary tract: cystitis

Prevention of endocardits: Prevention in patients in the risk group on endocarditis, for example, subjected to dental procedures

Early localized Lyme disease associated with migratory erythema (1 stage)

Mode of application and dose

Inside, before or after meals.

Adults and children over 12 years old (with a body weight of more than 40 kg): a daily dose from 750 mg to 3 g, divided into 2-3 receptions. Children at the age of 5-10 are prescribed 0.25 g 3 times a day; 2-5 years - 0.125 g 3 times a day; under 2 years old - 20 mg / kg 3 times a day. Course treatment - 5-12 days.

With acute uncomplicated gonor, 3G is prescribed once; In the treatment of women, it is recommended to repeat the specified dose.

With acute infectious diseases of the gastrointestinal tract (parathy, abdominal typhoids) and biliary tract, with gynecological infectious diseases, adults are 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

With leptospirosis, adults - 0.5-0.75 g 4 times within 6-12 days.

At silmosenelease adults - 1.5-2 g 3 times a day for 2-4 weeks.

For the prevention of endocarditis at small surgical interventions of adults - 3-4 g per 1 hour before the procedure. If necessary, prescribe a re-dose after 8-9 hours. Children dose are doubled.

In patients with impaired kidney function during creatinine clearance, 15-40 ml / min interval between receptions increase to 12 hours; When creatinine clearance, 10 ml / min dose is reduced by 15-50%; With anuria - the maximum dose of 2 g / day.

Preparation of suspension.

Monocoa package.

A pure cup is across boiled and cooled water (see table), then the contents of one package are poured and stirred to obtain a homogeneous suspension.

After taking a cup, rinse with water, dry and store in a dry, clean form.

Side effects

Often (³ 1% - < 10%)

- discomfort in the area of \u200b\u200bthe stomach, nausea, loss of appetite, vomiting, meteorism, diarrhea, diarrhea, enantum (especially on the mouth of the mouth), dry mouth, disruption of taste perception, (as a rule, the listed effects are characterized by an easy severity and often disappear as Continuing therapy or very quickly after it is terminated, it is possible to reduce the frequency of these complications by means of amoxicilline with meals)

Skin reactions in the form of Exanthemes, itching, urticaria (typical Corppy Exanthema appears on 5-11 days from the start of therapy; The immediate development of urticaria indicates an allergic reaction to amoxicillin and requires termination of therapy)

Infrequently (³ 0,1% - < 1%)

Development of superinfection and colonization of resistant microorganisms or mushrooms, for example, oral and vaginal candidiasis during prolonged and reuse of the medicinal preparation

Increase the level of hepatic transaminase (transient, moderate)

Seldom (³ 0,01% - < 0,1%)

Eosinophilia and hemolytic anemia

Sweets of larynx, serum disease, allergic vasculitis, anaphylaxis and anaphylactic shock

Reactions from the CNS, which include hypercines, dizziness and convulsions (convulsions can be observed in patients with renal failure, epilepsy, meningitis or in patients receiving high doses of the drug)

Surface discoloration of teeth (as a rule, discoloration is removed when cleaning the teeth)

Hepatitis and cholestatic jaundice

Angioedema edema (swelling of quinque), exudative multiform erythema, acute generalized mineral rash, Lailela syndrome, Stevens-Johnson syndrome, toxic epidermal necroliz, bullous and exfoliative dermatitis

Acute interstitial jade, crystallories

Drug Fever

Rarely (£ 0,01%)

Leukopenia, neutropenia, granulocyptopenia, pancytopenia, anemia, myelosuppression, agranulocytosis, lengthening the time of bleeding and prothrombin time (all changes were reversible when therapy ceases)

When developing severe persistent diarrhea, it is necessary to take into account the likelihood of pseudommbranous colitis (in most cases of the CLOSTRIDIUM Difficile)

Staining Language Black

Contraindications

Hypersensitivity to the preparation and its components (including to other penicillins, cephalosporins, carbapenes)

Allergic diathesis

Bronchial asthma

Pollnosis, infectious mononucleosis, lympholoicosis

Liver failure

Diseases of the gastrointestinal tract in history (especially colitis associated with the use of antibiotics)

Period lactation

Medicinal interactions

Antacids, glucosamine, laxatives, aminoglycosides - slow down and reduce amosine absorption; Ascorbic acid increases amosine absorption.

Amosin® is not destroyed in an acidic stomach environment, eating does not affect its absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) - synergistic effect; Bacteriostatic preparations (macrolides, chloramphenicol, lincoosamides, tetracycles, sulfonamides) - antagonistic.

Amosin® increases the efficiency of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives,medicines In the process of metabolism of which para-aminobenzoic acid is formed, ethinyl estradiol - the risk of "breakthrough" bleeding.

Diuretics, allopurinol, oxyphenbutayone, phenylbutazone, non-steroidal anti-inflammatory drugs; Preparations that block the tubular secretion - reducing the channel secretion, increase the concentration.

Allopurinol increases the risk of skin rash.

Reduces clearance and increases the toxicity of methotrexate.

Enhances the absorption of digoxin.

Stressed diuresis leads To reduce the concentration of the drug in the blood due to increasing the elimination of amoxicillin.

Recommended When determining the presence of glucose in the urine against the background of the use of amoxicillin use enzymatic glucose oxidase methods. When using chemical methods, the high concentration of amoxicillin in the urine may cause false positive results of the study.

Amoxicillin can Reduce the amount of estriol in the urine in pregnant women.

At high concentrations Amoxicillin can reduce the results of the level of glucose in blood serum.

When using Colorimetric methods Amoxicillin It may interfere with the definition of a protein.

special instructions

Carefully: Pregnancy, renal failure, bleeding in history.

In case treatment, it is necessary to monitor the condition of the function of the blood formation organs, liver and kidneys.

It is possible to develop superinfection due to the growth of microflora insensitive to it, which requires an appropriate change in antibacterial therapy.

In the treatment of patients with bacteremia, the reaction of bacteriolization is possible (Yarish-Gersheimer's reaction).

In patients having increased sensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

In the treatment of light diarrhea, against the backdrop of course treatment, antidiaryaric drugs that reduce the intestinal peristalsis should be avoided; Can be used kaolin - or attapulgite-containing anti-diagracial means. With severe diarrhea, it is necessary to consult a doctor.

Treatment necessarily continues 48-72 hours after the disappearance of clinical signs of the disease.

With the use of amoxicillin in high doses in order to minimize the risk of amoxicillinic crystallium, it is important to monitor the adequacy of consumption and removal of fluid.

Amosine should not be used to treat bacterial infections in patients with viral infections, acute lymphoblastic leukemia or infectious mononucleosis (due to increased risk of erythematous rash on the skin).

As with the use of other antibacterial agents, when using high doses of amoxicillin, it is necessary to regularly monitor blood indicators.

In the presence of severe disorders from the gastrointestinal tract with diarrhea and vomiting, amosyn ® should not be applied, since these states can reduce its suction. Such patients recommended the appointment of the parenteral form of amoxicillin.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, other or additional methods of contraception should be used as possible.

Pregnancy

The use of the drug during pregnancy is possible in the case when the intended benefit for the mother exceeds the potential risk to the fetus.

The duration of use should not exceed 7-10 days.

Features of the influence of the medicinal product on the ability to control the vehicle or potentially hazardous mechanisms

There were no messages about the effect of amosine on car control or work with mechanisms. However, some patients may occur headache and dizziness. In their occurrence, the patient must comply with special precautions when driving a car and working with mechanisms.

Overdose