Calcium-Sandoz ® forte. Calcium sandoz forte For impaired renal function

Calcium Sandoz Forte is a mineral supplement that replenishes calcium deficiency in the body.

Release form and composition

Calcium Sandoz Forte is available in the form of effervescent tablets, 10 and 20 pcs. in polypropylene cases, one case in a cardboard box.

Active ingredients of the drug:

  • Calcium lactogluconate - 1132 mg or 2263 mg per tablet;
  • Calcium carbonate - 875 mg or 1750 mg per tablet.

* which corresponds to the content of 500 mg or 1000 mg of Ca 2+ in one tablet, respectively.

Auxiliary components: citric acid, macrogol 6000, aspartame, sodium bicarbonate and orange flavoring containing sorbitol, butylhydroxyanisole (E320) and sulfur dioxide (E220).

Indications for use

  • Treatment and prevention of calcium deficiency, including in children during the period of their intensive growth, in pregnant and breastfeeding women;
  • Osteomalacia (as an adjunct drug);
  • Prevention and treatment of osteoporosis (in addition to specific therapy);
  • Allergic reactions (as maintenance therapy).

Contraindications

  • Hypercalciuria;
  • Hypercalcemia;
  • Nephrocalcinosis;
  • Nephrourolithiasis;
  • Chronic renal failure
  • Glucose-galactose malabsorption, sucrase / isomaltase deficiency and fructose intolerance;
  • Phenylketonuria;
  • Children under 3 years old;
  • Hypersensitivity to drug components.

Method of administration and dosage

The tablets are taken orally, dissolved immediately before taking in a glass of water, at any convenient time - regardless of the meal.

Children 3-9 years old are prescribed 500 mg per day, children over 10 years old and adults - 1000 mg per day. In severe cases and with an increased need for calcium (for example, during treatment with bisphosphonates), the daily dose may be increased to 2000 mg.

The duration of application of Calcium Sandoz Forte in each case is determined individually. When it is taken in order to compensate for the lack of calcium, the course of administration is at least 4-6 weeks.

Side effects

In general, the drug is well tolerated. In rare cases, the following are noted:

  • Hypersensitivity reactions, incl. hypercalcemia, pruritus, rash, urticaria;
  • Systemic allergic reactions - facial edema, angioedema, anaphylactic reactions;
  • Nausea, vomiting, flatulence, epigastric pain, constipation, or diarrhea.

With long-term intake of Calcium Sandoz Forte in high doses (2000 mg per day), headache, polyuria, and increased fatigue are possible.

An overdose of calcium leads to the development of hypercalciuria and hypercalcemia, manifested by thirst, nausea, vomiting, polyuria, polydipsia, dehydration, and constipation. Chronic overdose with hypercalcemia can lead to liming of organs and blood vessels. Intoxication threshold - long-term intake (for several months) more than 2000 mg of calcium per day.

At the initial stage of chronic overdose, the body is hydrated with 0.9% sodium chloride solution. In some cases, loop diuretics are used - they help increase the excretion of calcium and prevent the formation of edema in the tissues. In case of intoxication, it is necessary to restore the water-electrolyte balance.

In case of persistent hypercalcemia, an additional examination is prescribed to exclude other factors contributing to its development, including hypervitaminosis D and A, renal failure, primary hyperparathyroidism, stiffness of movements, and malignant tumors.

In patients with renal insufficiency, hydration is ineffective, so dialysis is prescribed.

special instructions

When taking Calcium Sandoz Forte during pregnancy, in order to prevent the development of hypercalcemia, which can cause disturbances in the fetus, do not exceed a dose of 1500 mg per day.

Patients with mild and moderate renal impairment, with minor hypercalciuria (exceeding 7.5 mmol / day), as well as with a history of urolithiasis, require regular monitoring of urinary calcium excretion. If necessary, you should reduce the dose or cancel the drug. In case of impaired renal function, in addition, the level of calcium and phosphate in the blood serum should be monitored.

Patients with a tendency to form calculi in the urinary tract during treatment should drink plenty of fluids.

Unless there are special indications for this, you should not take high doses of vitamin D and its derivatives while taking Sandoz Forte Calcium.

People who follow a diet with limited salt intake should take into account that 1 tablet of 500 mg contains 2.976 mmol of sodium, in 1 tablet of 1000 mg - 5.95 mmol (which is equivalent to 68.45 and 136.90 mg of sodium, respectively).

1 tablet of Calcium Sandoz Forte contains 0.002 XE, so the drug can be taken by patients with diabetes mellitus.

The mineral supplement does not have a negative effect on the ability for increased concentration and visual acuity.

The absorption of calcium from the gastrointestinal tract is reduced by foods containing oxalic acid (for example, rhubarb and spinach) and phytic acid (grains). For this reason, you should not take calcium 2 hours before or 2 hours after eating these foods.

Drug interactions

Calcium Sandoz Forte can reduce the absorption of etidronate, estramustine and, presumably, other bisphosphonates, fluoride preparations, quinolones and phenytoin. Therefore, at least 3-hour intervals should be observed between taking these funds.

Calcium absorption is enhanced by vitamin D and its derivatives.

The combination of high doses of calcium Sandoz Forte and vitamin D, when used simultaneously, reduces the effect of verapamil and possibly other calcium channel blockers.

With the combined use, the absorption of tetracycline antibiotics is disturbed, therefore it is recommended to take them 2 hours before or 4-6 hours after taking the calcium preparation.

An increase in the dose of Calcium Sandoz Forte may be required with the concomitant administration of systemic corticosteroids, since they reduce calcium absorption.

Urinary calcium excretion decreases with the use of thiazide diuretics, which increases the risk of hypercalcemia. During the period of treatment, it is necessary to regularly monitor the concentration of calcium in the blood serum.

Calcium Sandoz Forte may increase the toxicity of cardiac glycosides. Patients receiving these drugs require ECG monitoring and monitoring of blood calcium levels.

Terms and conditions of storage

Store in a tightly closed container in a place where the temperature does not exceed 30 ºC.

The shelf life is 3 years.

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which corresponds to the content of Calcium 500 mg

Release form

Effervescent tablets 20 pieces in a polypropylene case in a cardboard box.

pharmachologic effect

Calcium preparation for oral administration. Calcium is a vital mineral essential for maintaining electrolyte balance in the body and for the adequate functioning of numerous regulatory mechanisms. Replenishes Ca2 + deficiency in the body, participates in phosphate-calcium metabolism, has a vitamin, anti-rachitic, anti-inflammatory and anti-allergic effect.

Calcium-Sandoz Forte contains two calcium salts (calcium lactogluconate and calcium carbonate), which in the form of effervescent tablets dissolve quickly in water, turning into an active ionized form of calcium, which is easily absorbed. This dosage form provides an adequate intake of calcium in the body in the form of a tasty drink and is intended for the prevention and treatment of acute and chronic calcium deficiency in the body, as well as for the treatment of various types of metabolic disorders in bone tissue.

Indications for use

  • prevention and treatment of calcium deficiency (including pregnancy, lactation, period of intensive growth in children);
  • adding calcium to specific therapy in the prevention and treatment of osteoporosis;
  • allergic reactions (supportive therapy);
  • osteomalacia (as an adjunct to basic therapy, including with vitamin D3).

Method of administration and dosage

Inside, regardless of food intake. Before taking the tablet, dissolve in a glass of water.

Children aged 3 to 9 - 500 mg / day, adults and children from 10 years old - 1000 mg / day.

In severe cases or with an increased need for calcium (for example, during treatment with bisphosphonates), the dose may be increased to 2000 mg / day.

Prevention and treatment of osteoporosis: children aged 3 to 9 years - 500 mg / day, adults and children from 10 years old - 1000 mg / day.

Duration of therapy: when used to compensate for calcium deficiency, the average duration of treatment is at least 4-6 weeks. When used for prophylaxis as part of the complex therapy of osteoporosis, the duration of treatment is determined individually.

Contraindications

  • hypercalcemia;
  • hypercalciuria;
  • chronic renal failure;
  • nephrourolithiasis;
  • nephrocalcinosis;
  • phenylketonuria;
  • deficiency of sucrase / isomaltase, fructose intolerance, glucose-galactose malabsorption;
  • hypersensitivity to drug components.
  • calcium Sandoz Forte is not recommended for use in children under 3 years of age due to the lack of data on efficacy and safety in this category of patients.

Storage conditions

The drug should be stored in a tightly closed container at a temperature not exceeding 30 ° C.

Prevention and treatment of calcium deficiency; prevention and treatment of osteoporosis (in combination therapy); treatment of rickets and osteomalacia (in combination therapy with vitamin D3).

Pharmacotherapeutic group

Calcium-phosphorus metabolism regulator.

Pharmacological property

Calcium is a vital mineral essential for maintaining electrolyte balance in the body and for the adequate functioning of numerous regulatory mechanisms. Replenishes Ca2 + deficiency in the body, participates in phosphate-calcium metabolism, has a vitamin, anti-rachitic, anti-inflammatory and anti-allergic effect. Calcium Sandoz Forte contains two calcium salts (calcium lactogluconate and calcium carbonate), which in the form of effervescent tablets dissolve quickly in water, turning into an active ionized form of calcium, which is easily absorbed. This dosage form provides an adequate intake of calcium in the body in the form of a tasty drink and is intended for the prevention and treatment of acute and chronic calcium deficiency in the body, as well as for the treatment of various types of metabolic disorders in bone tissue.

Contraindications

Hypersensitivity to the components of the drug, increased concentration of calcium in the blood and urine (hypercalcemia, hypercalciuria), chronic renal failure, nephrourolithiasis, nephrocalcinosis, phenylketonuria and sucrose / isomaltose deficiency, fructose intolerance, glucose-galactose malabsorption. Calcium Sandoz Forte is not recommended for use in children under the age of 3 years due to the lack of data on efficacy and safety in this category.

Application

Inside, regardless of food intake. Before taking the tablet, dissolve in a glass of water. Children from 3 to 9 years old: 500 mg per day. Adults and children from 10 years old: 1000 mg per day. In severe cases or with increased calcium requirements (for example, in the treatment of bisphosphonates), the dose may be increased to 2000 mg per day. Duration of therapy : when used for the prevention and treatment of calcium deficiency, the average duration of the course of treatment is at least 4 - 6 weeks; when used for the prevention and treatment of osteoporosis, treatment of rickets and osteomalacia, the duration of treatment is determined individually.

Side effects

Immune system disorders: rarely: hypersensitivity reactions, incl. rash, itching, hives; very rare: in isolated cases, systemic allergic reactions (such as anaphylactic reactions, facial edema, angioedema) have been reported. Metabolic and nutritional disorders: infrequently: hypercalcemia, hypercalciuria. Disturbances from the gastrointestinal tract: rarely: flatulence, constipation, diarrhea, nausea, vomiting, abdominal pain. When taken in high doses (2000 mg / day with daily intake for several months), headache, increased fatigue, thirst, and polyuria may occur.

Overdose

Overdose leads to the development of hypercalciuria and hypercalcemia. Symptoms of hypercalcemia include nausea, vomiting, thirst, polydipsia, polyuria, dehydration, and constipation. Chronic overdose with the development of hypercalcemia can lead to liming of blood vessels and organs. The threshold of calcium intoxication - when taking calcium supplements for several months at a dose exceeding 2000 mg / day. Overdose therapy In case of intoxication, you should immediately stop therapy and restore the water-electrolyte balance. In case of chronic overdose, if signs of hypercalcemia are detected, hydration is performed at the initial stage using 0.9% sodium chloride solution. Loop diuretics such as furosemide can be used to enhance calcium excretion and to avoid tissue edema (eg, in congestive heart failure). In this case, you should refrain from using thiazide diuretics. In patients with renal insufficiency, hydration is ineffective, dialysis is indicated for such patients. In the case of persistent hypercalcemia, other factors contributing to its development should be excluded, including vitamin A or D hypervitaminosis, primary hyperparathyroidism, malignant tumors, renal failure, and stiffness of movement.

Interaction with other medicinal products

The combination of calcium carbonate + calcium lactogluconate & may reduce the absorption of estramustine, etidronate and possibly other bisphosphonates, phenytoin, quinolones, oral tetracycline antibiotics, and fluoride preparations. The interval between taking effervescent tablets of calcium carbonate + calcium lactogluconate & and the above drugs should be at least 3 hours. The simultaneous administration of vitamin D and its derivatives increases the absorption of calcium. When given in high doses along with vitamin D and its derivatives, calcium can reduce the effects of verapamil and possibly other calcium channel blockers. With the simultaneous use of tablets of effervescent calcium carbonate + calcium lactogluconate & and tetracycline preparations, the absorption of the latter may be impaired. For this reason, tetracycline drugs should be taken at least 2 hours before or 4-6 hours after oral calcium supplementation. Thiazide diuretics reduce urinary calcium excretion, therefore, when used simultaneously with calcium carbonate + calcium lactogluconate effervescent tablets, serum calcium concentration should be monitored regularly, as there is a risk of hypercalcemia. Systemic corticosteroids decrease calcium absorption. With their simultaneous use, it may be necessary to increase the dose of effervescent calcium carbonate + calcium lactogluconate & tablets. When ingesting tablets of effervescent calcium carbonate + calcium lactogluconate & in patients receiving cardiac glycosides, an increase in the toxicity of cardiac glycosides is possible due to the development of hypercalcemia. Such patients should regularly take an ECG and monitor the level of calcium in the blood serum. With the simultaneous administration of sodium bisphosphonate or sodium fluoride, these drugs should be taken at least 3 hours before taking effervescent calcium carbonate + calcium lactogluconate tablets &, since absorption from the gastrointestinal tract (GIT) of bisphosphonate or sodium fluoride may decrease. The absorption of calcium from the gastrointestinal tract can be reduced with the simultaneous intake of certain types of food containing oxalic acid (for example, spinach, rhubarb) or phytic acid (in all grains) due to the formation of insoluble complexes with calcium ions. Patients should not take an effervescent tablet of calcium carbonate + calcium lactogluconate & 2 hours before or after meals rich in oxalic or phytic acid.

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Calcium Sandoz is a pharmaceutical preparation that compensates for calcium deficiency in the body.

pharmachologic effect

Calcium Sandoz is intended for oral administration. Calcium is a vital mineral that maintains electrolyte balance in the body and also helps numerous regulatory mechanisms function properly.

Calcium Sandoz is involved in phosphorus-calcium metabolism and has antiallergic, antirachitic effect. This drug is available in the form of effervescent tablets, which contain a high dose of rapidly dissolving ionized Ca salts.

Calcium Sandoz Forte is a dosage form that provides calcium in the form of a pleasant-tasting drink.

Pharmacokinetics

About 30 percent of calcium is absorbed from the digestive tract. According to biological data, bones and teeth contain 99 percent of all Ca in the body.

50 percent of Ca is ionized calcium, 5 percent is found in anionic complexes, and 45 percent of calcium binds to proteins. About 20 percent of Ca is excreted in urine and 80 percent is excreted in the feces.

With feces, calcium is excreted as an unabsorbed element. Also, this element is excreted as an adsorbed substance, which is excreted in bile and pancreatic secretions.

Method of administration and dosage

According to the instructions, Calcium Sandoz should be taken 1-2 tablets per day. If the patient has a severe case, the dose should be increased to 4 tablets per day (4 tablets are equal to two grams of ionized calcium).

Before taking a tablet, it must be dissolved in water.

Indications for use

The drug is prescribed in the following cases:

  • For the prevention of postmenopausal bone demineralization;
  • Osteoporosis;
  • To soften bone tissue (the drug is used as adjunctive therapy);
  • Rickets;
  • The drug is prescribed in those conditions that are characterized by an increased need for calcium. This can be pregnancy, lactation, intensive growth in children;
  • The drug is used for allergic reactions (used as an adjuvant).

Application for impaired renal function

People with mild to moderate renal impairment should be regularly monitored for urinary calcium excretion. If necessary, the dose should be reduced or canceled.

Contraindications

Calcium Sandoz Forte is not used in cases where the patient has an increase in calcium levels, severe renal failure, hypercalciuria. The drug is not prescribed for hypersensitivity to the drug or its individual components.

Interaction with alcohol

No data were reported on interactions with alcohol. When taking calcium, it is recommended to refrain from drinking alcohol containing a high percentage of alcohol.

Overdose

Cases of acute overdose have not been reported. According to the instructions, Calcium Sandoz can cause gastrointestinal disturbances, but will not lead to hypercalcemia (as an exception, the fact that the patient was simultaneously prescribed high doses of vitamin D or its derivatives).

Drug Interactions Calcium Sandoz

Effervescent tablets of Calcium Sandoz forte are designed to reduce the absorption of etidronate, estramustine, quinolones, and other bisphosphonates, as well as fluoride preparations.

If the patient is prescribed a drug with the simultaneous use of vitamin D, then it increases the absorption of calcium.

Absorption of calcium from the gastrointestinal tract decreases with certain foods. This includes rhubarb, cereal bran, and spinach. If the drug is administered with vitamin D, calcium reduces the response to verapamil.

Pregnancy and lactation

During pregnancy, the daily dose of calcium should be more than 1500 milligrams. If the mother develops hypercalcemia, this can greatly affect the mental and physical development of the fetus.

Conditions and shelf life

Calcium Sandoz should be stored at a temperature not exceeding 25 degrees Celsius.

Shelf life is 3 years.

The drug is dispensed from pharmacies without a prescription.

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