How to properly use ACC for cough. How to take ACC before meals or after
Registration number:P N015473 / 01
Trade name of the drug: АЦЦ® 200
International non-proprietary name: acetylcysteine \u200b\u200b(acetylcysteine)
Chemical name: N-acetyl L-cysteine
Dosage form: effervescent tablets
Composition:
1 effervescent tablet contains 200 mg of acetylcysteine.
Other components:
Ascorbic acid, citric acid anhydride, lactose anhydride, mannitol, sodium citrate, sodium bicarbonate, saccharin, blackberry flavor.
Description: white, round, scored flat tablets with a blackberry smell.
Pharmacological properties:
Pharmacotherapeutic group: mucolytic agent.
ATX code: R05СВ01
Pharmacodynamics:
The presence of sulfhydryl groups in the structure of acetylcysteine \u200b\u200bcontributes to the rupture of disulfide bonds of acidic mucopolysaccharides of sputum, which leads to a decrease in the viscosity of mucus. The drug remains active in the presence of purulent sputum. With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.
Indications for use:
Diseases of the respiratory system, accompanied by the formation of viscous difficult to separate sputum: acute and chronic bronchitis, obstructive bronchitis, pneumonia, bronchiectasis, bronchial asthma, bronchiolitis, cystic fibrosis.
Acute and chronic sinusitis, otitis media (otitis media).
Contraindications:
Hypersensitivity to acetylcysteine \u200b\u200bor other ingredients of the drug. Peptic ulcer of the stomach and duodenum in the acute stage, hemoptysis, pulmonary hemorrhage, pregnancy, breastfeeding.
With caution - varicose veins of the esophagus, bronchial asthma, adrenal diseases, hepatic and / or renal failure.
Acetylcysteine \u200b\u200bshould be used with caution in patients prone to pulmonary bleeding, hemoptysis.
Pregnancy and lactation period:
As a safety measure, due to insufficient data, prescribing the drug during pregnancy and lactation is possible only if the intended benefit to the mother outweighs the potential risk to the fetus or infant.
Dosage:
In the absence of other appointments, it is recommended to adhere to the following dosages:
2 - 3 times a day, 1 effervescent tablet (400 - 600 mg of acetylcysteine \u200b\u200bper day).
3 times a day for 1/2 effervescent tablet, or 2 times a day for 1 effervescent tablet (300 - 400 mg of acetylcysteine).
2 - 3 times a day, 1/2 effervescent tablet (200 - 300 mg acetylcysteine).
Patients with cystic fibrosis and weighing more than 30 kg, if necessary, may increase the dose to 800 mg of acetylcysteine \u200b\u200bper day.
Children over the age of 6 are advised to take 1 effervescent tablet 3 times a day (600 mg of acetylcysteine \u200b\u200bper day).
Children aged 2 to 6 years - 4 times a day, 1/2 effervescent tablet (400 mg of acetylcysteine \u200b\u200bper day).
Effervescent tablets should be dissolved in half a glass of water and taken after meals.
The tablets should be taken immediately after dissolution, in exceptional cases, you can leave the solution ready for use for 2 hours.
Additional fluid intake enhances the mucolytic effect of the drug.
For short-term colds, the duration of admission is 5 - 7 days.
In chronic bronchitis and cystic fibrosis, the drug should be taken for a longer time to achieve a prophylactic effect against infections.
1 effervescent tablet equals 0.006 bread. units
Side effects:
In rare cases, there are headaches, inflammation of the oral mucosa (stomatitis), tinnitus. It is extremely rare - diarrhea, vomiting, heartburn and nausea, drop in blood pressure, increased heart rate (tachycardia). In isolated cases, allergic reactions are observed, such as bronchospasm (mainly in patients with bronchial hyperreactivity), skin rash, itching and urticaria. In addition, there are isolated reports of the development of bleeding due to the presence of hypersensitivity reactions. With the development of side effects, you should stop taking the drug and consult a doctor.
In case of an erroneous or deliberate overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea are observed. To date, no serious and life-threatening side effects have been observed.
Interaction with other drugs:
With the simultaneous use of acetylcysteine \u200b\u200band due to suppression of the cough reflex, mucus stagnation may occur. Therefore, such combinations should be selected with care.
Simultaneous reception of acetylcysteine \u200b\u200band can lead to an increase in the vasodilating effect of the latter.
Pharmaceutically incompatible with antibiotics (penicillins, cephalosporins, erythromycin, tetracycline and amphotericin B) and proteolytic enzymes.
Upon contact with metals, rubber sulphides are formed with a characteristic odor.
Reduces the absorption of penicillins, cephalosporins, tetracycline (they should be taken no earlier than 2 hours after ingestion of acetylcysteine).
Special instructions:
Patients with bronchial asthma and obstructive bronchitis should be prescribed acetylcysteine \u200b\u200bwith caution under systematic monitoring of bronchial patency.
When treating patients with diabetes mellitus, it should be borne in mind that the tablets contain sucrose: 1 effervescent tablet corresponds to 0.006 bread. units
When working with the drug, it is necessary to use glassware, avoid contact with metals, rubber, oxygen, easily oxidized substances.
Release forms:
20 or 25 tablets in an aluminum or plastic tube.
1 tube of 20 tablets or 2 or 4 tubes of 25 tablets each with instructions for use in a cardboard box.
4 tablets in strips of 3-layer material: paper / polyethylene / aluminum.
15 strips with instructions for use in a cardboard box.
Storage conditions:
Store in a dry place out of the reach of children at a temperature not exceeding 25 ° C.
Close the tube tightly after taking the pill!
Shelf life of the medicinal product:
3 years.
Do not use after the stated expiration date.
Pharmacy dispensing:
Without recipe.
Manufacturer:
Hexal AG, produced by Salutas Pharma GmbH, Germany,
83607, Holzkirchen, Industrialstrasse 25, Germany.
Many pathologies of the respiratory organs are accompanied by a painful cough. In this case, regardless of whether it is dry or wet, the patient tries to get rid of this unpleasant symptom as soon as possible. In pharmacies, you can find many medicines that will help cure a cough in a short time, including ACC. The medication can be prescribed for both dry and productive cough... With a dry cough, ACC increases the volume of mucus produced and promotes its discharge, and with a wet cough it helps to easily remove mucus from the respiratory organs.
General characteristics of the drug
The pharmaceutical industry produces the ACC medication in several doses and forms. There is also a long-acting drug that should not be drunk more than 2 times a day.... In pharmacies you can find the following forms of the drug:
- soluble cough tablets;
- solution for inhalation;
- powder, when diluted in water, a drink is obtained;
- sweet syrup. This form of medication is convenient to prescribe when treating a cough in a small child;
- solution for intravenous and intramuscular injection.
The active component of these dosage forms is acetylcysteine. In addition, each type of drug is distinguished by some auxiliary components. So, in granules, among other things, there is a citrus flavor, in soluble tablets - blackberry, and in syrup - cherry.
ACC can be prescribed for both unproductive and wet cough. The acetylcysteine \u200b\u200bcontained in the drug promotes the rapid removal of sputum from the bronchi and lungs. Taking ACC, the patient should drink a lot, in this case, the effect of the drug is enhanced, the sputum clears up well.
The effect of this drug has not yet been fully understood.... Acetylcysteine \u200b\u200bhas a pronounced mucolytic, expectorant and antioxidant effect. Recent studies have shown that this substance is capable of effectively removing toxic substances from the body. However, most often, ACC is used for wet and dry coughs to facilitate the passage of sputum. This medication is able to thin thick phlegm, and then gently removes it from the respiratory organs. Among other things, acetylcysteine \u200b\u200bhas a mild anti-inflammatory effect.
ACC can be prescribed for the treatment of both adults and children of different ages. In the latter case, the required dose is calculated by the attending physician.
Indications
Taking ACC for coughing, you can notice a positive result just an hour after the start.... Most often, doctors prescribe to patients with coughing granules for making a solution and original dissolving tablets. These medicines are considered to be more convenient to use. You can start taking one or another form of the drug only on the recommendation of a doctor, since they affect the respiratory organs in different ways.
Acetylcysteine \u200b\u200bsyrup will quickly help eliminate cough in chronic lung pathologies, and a special solution for inhalation is very effective in laryngotracheitis.
The drug is prescribed by physicians for pathologies of the respiratory organs, which are accompanied by different types of cough, namely:
- bacterial and viral pneumonia;
- bronchitis of a different nature;
- cystic fibrosis and asthma;
- various types of sinusitis;
- otitis.
ACC for bronchitis and pneumonia is prescribed only as part of complex therapy. In this case, in addition to ACC, antibiotics and medications of other groups are often prescribed.
Most often, ACC is prescribed for a productive wet cough. This medication can also be used with an unproductive cough, but only if the patient has already taken medications to dilute too thick sputum. At the same time, the viscous mucus in the respiratory organs has already thinned out, the cough has become productive. Otherwise, ACC will not have any effect from an exhausting dry cough.
With a dry cough, people are usually prescribed ACC Long, but only in conjunction with drugs that help thin phlegm.
Prescribing ACC to children with a dry cough, it is worth immediately telling the parents that the treatment will give a noticeable result if the drinking regime is observed, and in addition to this drug, the child will take syrups based on licorice root or medicines containing ambroxol.
Contraindications
- pulmonary bleeding;
- coughing up sputum mixed with blood;
- chronic renal failure;
- septic;
- hepatitis;
- special sensitivity to the ingredients in the preparation.
During pregnancy and breastfeeding, the drug can be prescribed only in special cases when there is no alternative. In this case, the expected benefit for the expectant mother should be higher than the possible harm to the child.
Side effects
ACC can cause certain side effects. When treating with this medication, there is a high probability of the appearance of such disorders:
- there may be persistent headaches and persistent tinnitus;
- heartburn, persistent nausea and stool disorders;
- increased heart rate and low blood pressure.
The annotation to ACC Long contains information that there may be allergic reactions that look like a skin rash.
How to drink medication
The dosage of ACC depends not only on the age of the person and the severity of the disease, but also on the type of drug. All types of ACC have a certain daily dosage..
ACC 100 can be given to babies almost from birth. For crumbs up to 2 years old, a medication of 50 mg is prescribed three times a day. A 100 mg soluble tablet is divided in half and then diluted in 0.5 glasses of water.
From 2 to 5 years old, the child drinks the medicine 4 times a day, a single dose is 100 mg. Children over 6 years old drink ACTS 200 three times a day.
ACC Long can be prescribed to patients from the age of 14. The daily dose is 600 mg, it is drunk at a time. The effervescent tablet is dissolved in water and drunk immediately after a meal.
You need to understand that if the prepared drug did not work out to drink for some reason, then it must be taken no later than a couple of hours after dilution. If more time has passed, then a fresh medicinal drink is prepared.
ACC 200 can only be taken as an aqueous solution. It is prescribed for children who are already six years old. You can consume 2 sachets per day, which are previously diluted in warm water. Adolescents after 14 years and adult patients consume a whole sachet of the previously diluted drug three times a day.
It is permissible to dilute the powder for the solution in water, cold tea, favorite juice or cooled compote... The powder for preparing the solution is poured with clean water until the marks marked on the bubble, and then mixed well, having previously closed the lid. After taking the medicine, you must definitely drink enough water or other drink, in which case the effectiveness of the treatment will be higher.
If ACC does not help with coughing at all for 4-5 days, then you need to consult a doctor, perhaps a dose adjustment is needed. The minimum course of treatment is 5 days, but if necessary, therapy can last up to six months.
Babies can be diluted with ACC in water, and then given through a bottle with a nipple.
Features of treatment of pregnant women
In women, during the period of bearing a child, immunity is greatly reduced, therefore the frequency of respiratory infections increases. For the treatment of pregnant women, doctors select drugs that will not have a negative effect on the fetus. The effect of ACC on pregnant women has not yet been fully studied, but based on the fact that it is prescribed for infants, it is possible to take this medicine for expectant mothers. The dose of medicine for this group of patients is determined by the doctor.
If alarming symptoms appear while taking the drug, treatment is stopped and contact a medical facility.
ACC is a highly effective remedy for wet and dry coughs, which can also be purchased at a low price. The form and dose of the medicine is selected by the doctor individually, but more often they prescribe soluble tablets and packaged powder for preparing a healing drink.
The drug "ACC" (in Russian, more often called ACC), is prescribed for cough in the treatment of colds of various types. In addition, the drug is prescribed in the presence of allergic cough spasms, has several forms of release and dosage options, the choice of which depends on the age and weight of the patient. The longest duration of action is distinguished by "ACTS Long", the effect of which lasts for 12 hours. The last variation of the drug is taken only twice a day.
Cough spasms in their types can be both productive, in which sputum is released, and dry, most often manifested at the initial stage of a cold ailment. Initially, the drug is positioned by manufacturers as a remedy for wet coughs, which helps remove phlegm from the respiratory system and makes breathing easier. However, "ACC" also helps with dry cough, bringing it to the productive stage.
In medical practice, it is customary to prescribe this medicine in various forms for the following ailments:
It should be borne in mind that the clinical benefit from this drug is possible only if it is used to treat ailments included in the list of those indicated above. Thus, you should not try to stop the cough spasm with the help of "ACC" yourself. If the drug does not give any effect, then, most likely, the disease does not belong to the profile of its action.
How does the medicine work?
The drug "ACC" is considered an excellent way to combat phlegm that occurs in the cavity of the respiratory tract, lungs and bronchi due to various kinds of infectious lesions. At the same time, phlegm, trying for natural reasons to get out, provokes a cough, and often this substance turns out to be too viscous and dense, which leads to its too strong adhesion to the bronchi. With the help of "ACC" it is possible not only to fully establish, but also to promote the process of sputum discharge from the respiratory system and its excretion.
The main component of the drug is a cysteine \u200b\u200bderivative, this amino acid directly affects the structure of sputum, changing its consistency. The mucus increases in its condition, easily detaches from the bronchi and is naturally excreted from the airway cavity. In connection with the removal of sputum, the healing process takes place, and the protective reactions of the mucous membranes are restored.
It is noteworthy that the action of "ACC" is aimed at eliminating not only ordinary mucous sputum, but also the one in which purulent formations have already appeared. The drug is often used in conjunction with antibacterial drugs, since it facilitates the penetration of the latter into the mucous part of the respiratory system. At the same time, it is important to observe the two-hour interval between medications. In addition to an active effect on phlegm, cough medicine has antioxidant properties, respectively, acetylcysteine \u200b\u200bsignificantly facilitates the course of any viral infection.
In fact, the drug eliminates the manifestation of symptoms characteristic of a strong flu, while simultaneously fighting cough spasms.
Instructions for the use of tablets and powder ACC (ass) for dry cough
The correct dosage of the drug is calculated based on the type of ailment from which therapy is carried out, the age and weight of the patient. In addition, the dosage of "ACC" for dry cough for children and adults is different. When treating such a serious ailment as mucoviscytosis, the daily dose of the drug is no more than 800 mg, provided that the patient's weight exceeds the mark of 30 kg. The duration of therapy can be very long and be at least 3-6 months. Treatment should be carried out only under the supervision of a doctor and taking into account the use of a complex of drugs.
For the treatment of dry type cough spasm for other diseases of the respiratory tract for people from the age of 14, a dosage of 400 to 600 mg of the drug in the form of tablets or powder consistency at one time is indicated. If there is a too acute course of the disease, then taking drugs under the supervision of a doctor lasts at least a week. With a chronic ailment, a dry cough with the help of tablets or ACC powder can be treated for about six months.
According to the instructions for use, if there are no other doctor's prescriptions, the drug is taken immediately after a meal as an expectorant. The method of using the medicine is as follows: powder or a certain number of tablets are dissolved in ½ glass of water or tea and immediately drunk.
Taking medicine for children is carried out according to a different scheme, and here the important point is the type of drug relative to the dosage of the active component in it:
- "ACC 100" is approved from birth for the treatment of dry cough in infants. The dosage under the age of 2 years is three times a day in the amount of 50 mg, then the dosage is increased to 100 mg in four doses, and after six years this medication should be taken at a dosage of 600 mg per day, which should be divided into three doses.
- "ACTS 200" is allowed only at the age of a child whose mark has exceeded 6 years, and the use of the drug is allowed only in the form of a solution. Do not use more than two sachets of powder dissolved in water during. For adolescents over the age of 14, the number of sachets is brought to three, which is equal to the adult dosage.
- "ACTS Long" is allowed only after 14 years, the daily dosage of this type of drug should not exceed 600 mg, and the patient should receive it at one time. The tablet dissolves in water and is taken orally immediately after a meal. The storage time of the solution does not exceed half an hour, otherwise the tablet must be re-dissolved for a new solution.
Children's cough syrup Ass
For the treatment of cough in children, manufacturers produce a special form of the drug "ACC" in the form of a syrup, the reception and tolerance of which is much easier than a solution obtained on the basis of tablets or powder. The medicine in this form is also convenient because it is already ready for use and does not require additional dilution steps.
The syrup dosage is calculated using a measuring cup, and it itself depends on the age and, accordingly, the weight of the child. In particular, 5 ml of the preparation equals one quarter of the cup.
If the child's age lies in the aisles from 2 to 6 years, then 5 ml should be taken no more than three times a day. After 7 years, the number of doses increases to 3-4, or it is permissible to use 10 ml at a time, but twice a day. After 15 years, the daily dose is 10 ml 3 times a day. The preparation also contains a special syringe for the convenience of calculating the dosage. Its use is very convenient for treating very young children.
Contraindications and side effects
Like any medication, "ACC" for cough has its own contraindications, non-observance of which can lead to side effects. According to the instructions developed by the manufacturers of the drug, it is prohibited to be taken in the following cases:
- coughing up blood mucus;
- bleeding in the lungs;
- intolerance to fructose at the genetic level;
- individual intolerance to the main component of the drug and other substances in its composition;
- renal failure, various liver diseases, especially hepatitis;
- the presence of a peptic ulcer.
As side effects when taking this drug, it is customary to consider such phenomena as various allergic reactions, heart palpitations, heartburn, general disruption of the gastrointestinal tract, which manifests itself in the form of diarrhea and vomiting, headaches and tinnitus.
Allergic reactions are typical in the presence of individual intolerance to the substances in the composition of the drug, in this case, immediate discontinuation of the drug is required due to the risk of Quincke's edema. In other cases, the study of the drug did not lead to the identification of any situations in which its intake would pose a threat to human life. If any signs of side effects appear, you should immediately stop taking the drug and consult your doctor for adjusting the treatment regimen.
The drug "ACC" is successfully used to treat various ailments, accompanied by a dry and productive cough. The drug and its dosage should only be prescribed by a doctor after diagnosis.
Children's immunity is formed gradually. This is the reason for the special susceptibility to colds. One of the most unpleasant symptoms of a cold is coughing.
It can be dry or wet. With a dry cough, there is pain and discomfort in the throat. For its treatment, ACC powder for children is prescribed.
This article discusses instructions for using ACC powder (100 and 200 mg) for children, collects parental reviews of the drug for children, indicates the price of the drug.
Composition and pharmacological properties
ACC is a medicine to combat. Produced in Germany and Slovenia, has an expectorant and anti-inflammatory effect.
The main active ingredient of the drug is acetylcysteine. Auxiliary components - sodium saccharinate, ascorbic acid, sucrose and flavoring.
The drug is available in tablet and powder formats. The second option is prescribed in childhood.
The package contains 20 bags of granules. They are white in color and have a pleasant aroma. Depending on the additive, it can be lemon, orange, or honey.
ACC has an expectorant effect. It is also prescribed when a purulent type of sputum occurs.
It is possible to use the drug for prophylactic purposes, for chronic diseases of the respiratory system.
Indications
ACC powder is prescribed for any type of disease that accompanies sputum production in the pulmonary tract.
A drug makes coughing more productive... The active ingredient reduces inflammation, making the child feel better.
The indications indicated in the instructions for the medicine:
Before prescribing the drug, the doctor must listen to the baby's breathing with a phonendoscope.
In the presence of viscous and thick sputum, exhalation will be prolonged, and breathing will be heavy, with moist wheezing.
Contraindications
Prescribing the dosage of the drug in the presence of diseases of the gastrointestinal tract is carried out with caution.
With individual histamine intolerance, long-term administration of ACC is not recommended.
Doctors advise to use ACC with caution in case of a tendency to varicose veins in the esophagus.
In case of renal or hepatic insufficiency during treatment, it is necessary to monitor the condition of the organs through tests.
Direct contraindications for taking medicinal granules:
- bleeding in the lungs;
- the presence of sensitivity to the components of the drug;
- acute form of gastrointestinal diseases;
- age up to 2 years;
- intolerance to fructose.
How quickly it helps
Active ingredient of the drug has the property of thinning phlegm using the process of mucoprotein depolymerization.
The antioxidant effect is based on the ability to bond with oxidative radicals, eliminating their vitality. The intensity of the inflammatory process decreases.
The metabolism of the active substances of the drug is carried out in the liver. The maximum concentration of components in blood cells is reached approximately 2 hours after ingestion. The excretion process is carried out by the kidneys.
Sputum discharge is noted on the first day of using the drug.
The complete disappearance of the cough reflex occurs after a full course of treatment. Its duration depends on the severity of the disease.
Dosage - 100 or 200 mg
How to drink ACC powder for children? Mucolytic therapy involves adherence to the dosage prescribed by the doctor.
At the age of 2 to 6 years, it is allowed to take 100 mg of the drug no more than 3 times a day. At the age of 6 to 14 years, a single dose is 200 mg. But the number of receptions remains the same.
The daily dose for adolescents from the age of 14 is 400-600 mg of the drug per day. This amount is stretched over 2 doses.
In severe cases, the dosage is increased. If the child's body weight exceeds 30 kg, then the daily dose of the drug can reach 800 mg.
How to breed and take, special instructions
Before use, ACC powder must be dissolved in hot water. 100 mg of the drug will require 100 ml of liquid.
The resulting ACC solution (suspension) for children is taken orally, hot, regardless of food.
Without supervision by medical representatives, the drug can be used no longer than 5 days. With complications of the course of the disease, the course of treatment is extended. But this nuance is discussed with the attending physician.
In the presence of diabetes mellitus, ACC should be used with caution. The drug contains sucrose. This is taken into account when prescribing a dosage.
Possibility of combining with other substances
The combination of ACC powder with agents of a similar action can lead to stagnation of sputum in the respiratory organs.
Concomitant use with antibiotics such as tetracycline, penicillin and cephalosporin is undesirable. Acetylcysteine \u200b\u200breduces the antibacterial effect of these components.
ACC increases the vasodilating effect of nitroglycerin, so it is advisable to reduce its dosage.
Any combination of ACC with medications is discussed with a pediatrician to prevent possible side effects.
Overdose and side effects
Overdose is possible during treatment, therefore, you should adhere to the dosage regimen prescribed by your doctor.
Exceeding the dosage is fraught with the appearance of characteristic symptoms. These are stomach pain, stool disturbance, nausea, heartburn.
In this case, gastric lavage is indicated. You should observe bed rest and stop using the drug.
Side effects may occur during treatment:
There are two options for package sizes - 100 and 200 mg. The package contains 20 portion bags.
The cost of a drug with a dosage of 100 mg is 130 rubles. In some areas, it reaches 150 rubles. The average price of a package with a dosage of 200 mg is 180 rubles.
The optimum storage temperature should not exceed 25 degrees. Store the powder package in a dark place.
The shelf life is 4 years from the date of issue. After its expiration, the use of the drug is prohibited.
Name:
ACC
Pharmacological
act:
Acetylcysteine \u200b\u200b(ACC) - mucolytic, expectorant, which is used to thin sputum in diseases of the respiratory system, accompanied by the formation of thick mucus. Acetylcysteine \u200b\u200bis a derivative of the amino acid cysteine.
The mucolytic effect of the drug is chemical in nature.
Due to the free sulfhydryl group, acetylcysteine \u200b\u200bbreaks the disulfide bonds of acidic mucopolysaccharides, which leads to depolymerization of mucoproteins in sputum and a decrease in mucus viscosity and promotes expectoration and discharge of bronchial secretions.
The drug remains active in the presence of purulent sputum.
Acetylcysteine also has antioxidant pneumoprotective properties, which is due to the binding of its sulfhydryl groups of chemical radicals and, thus, neutralizing them.
In addition, the drug helps to increase the synthesis of glutathione - an important factor of intracellular protection not only against oxidative toxins of exogenous and endogenous origin, but also against some cytotoxic substances.
This feature of acetylcysteine \u200b\u200bmakes it possible to effectively use the latter in case of paracetamol overdose.
After oral administration, acetylcysteine quickly and completely absorbed and undergoes metabolism in the liver with the formation of cysteine, a pharmacologically active metabolite, as well as diacetylcysteine, cystine and further mixed disulfides.
Bioavailability is very low - about 10%.
Cmax in blood plasma is reached within 1-3 hours after administration. Plasma protein binding - 50%.
Acetylcysteine \u200b\u200bis excreted by the kidneys as inactive metabolites (inorganic sulfates, diacetylcysteine).
T½ is determined mainly by rapid biotransformation in the liver and is about 1 hour. In the case of a decrease in liver function, T½ increases to 8 hours.
Indications for
application:
Acetylcysteine \u200b\u200bis prescribed in all cases of diseases with the accumulation of thick viscous sputum in the bronchial tree and upper respiratory tract, namely:
- acute and chronic bronchitis, including obstructive;
- bronchiolitis;
- tracheitis;
- bronchial asthma;
- bronchiectasis;
- cystic fibrosis;
- laryngitis;
- sinusitis;
- exudative otitis media.
Mode of application:
Daily dose for the treatment of cystic fibrosis patients weighing more than 30 kg are used up to 800 mg.
Children from the 10th day of life and up to 2 years old are used 50 mg 2-3 r / s.
At the age of 2-5 years - 400 mg per day, divided into 4 doses. From 6 years old - 600 mg / s (divided into 3 doses).
Treatment is continued for a long time, in courses of several months (3-6).
In all other cases, the daily dose for children from 14 years of age and adults is 400-600 mg. From 6 to 14 years old - 300-400 mg (divided into 2 doses), 2-5 years old - 200-300 mg (divided into 2 doses).
Children from the 10th day of life and up to 2 years old are used 50 mg 2-3 r / s.
For acute illnesses without complications the drug is prescribed for 5-7 days.
In case of complications or in a chronic course, course treatment is possible (up to 6 months).
ACC is taken after meals.
The tablet or the contents of the sachet must be dissolved in half a glass of liquid (iced tea, water, juice).
Side effects:
The following classification is used to describe the frequency of side effects: very often (≥1 / 10), often (≥1 / 100,<1/10), нечасто (≥1/1000, <1/100), редко (≥1/10 000, <1/1000), очень редко (<1/10 000).
On the part of the cardiovascular system: infrequently - tachycardia, arterial hypotension.
From the nervous system: infrequently - headache.
From the skin: infrequently - allergic reactions (itching, urticaria, exanthema, eczema, rash, angioedema).
From the organ of hearing: infrequently - ringing in the ears.
From the respiratory system: rarely - shortness of breath, bronchospasm (mainly in patients with hyperreactivity of the bronchial system, which is associated with BA), rhinorrhea.
From the digestive tract: infrequently - heartburn, dyspepsia, stomatitis, abdominal pain, nausea, vomiting, diarrhea, bad breath.
General disorders: infrequently - fever.
Some severe skin reactions (Stevens-Johnson and Lyell syndromes) have been reported.
With the use of acetylcysteine, bleeding was very rarely reported, which was most often associated with the development of hypersensitivity reactions.
There have been cases of decreased platelet aggregation, but there is no clinical confirmation of this.
Rarely Quincke's edema, facial edema, cases of anemia, hemorrhages, anaphylactic reactions, or even shock have been reported.
Contraindications:
Hypersensitivity to acetylcysteine \u200b\u200band excipients;
- peptic ulcer;
- hereditary fructose intolerance;
- pulmonary bleeding or hemoptysis;
- in pediatric practice - with hepatitis and renal failure (threat of accumulation of nitrogen-containing products).
Carefully apply ACC with peptic ulcer of the stomach or duodenum.
When preparing a solution, a patient with bronchial asthma can inhale air with particles of the drug, which irritates the mucous membranes of the upper respiratory tract and can provoke reflex bronchospasm.
For the best mucolytic effect, plenty of fluids should be taken when treating with acetylcysteine.
10 ml of the finished oral solution contains 0.31 carbohydrate units, which should be taken into account by patients with diabetes mellitus.
Sorbitol has a slight laxative effect on stools.
Newborns and children under 1 year of age acetylcysteine \u200b\u200bis used exclusively for health reasons under strict medical supervision. The recommended dosage (10 mg / kg body weight) must not be changed.
ACC 200 is not used under the age of 2 years.
ACC Long is not recommended for children under 14 years of age.
Quick response when driving and working with equipment does not change when taking acetylcysteine.
Interaction
other medicinal
by means of:
Tetracycline and its derivatives (except doxycycline) should not be used together with ACC in pediatrics.
During experimental studies in vitro, there were no cases of inactivation of other types of antibacterial drugs.
Nonetheless, it is recommended to observe the interval between taking ACC and antibiotic at 2 o'clock (at least).
In vitro, the incompatibility of acetylcysteine \u200b\u200bwith semisynthetic penicillins, aminoglycoside and cephalosporin antibiotics has been proven. Such studies have not been conducted with erythromycin, amoxicillin, and cefuroxime.
The simultaneous use of antitussives can lead to stagnation of the secretions of the respiratory tract.
Application with nitroglycerin can enhance the vasodilating effect of the latter.
Pregnancy:
The embryotoxic effect of acetylcysteine \u200b\u200bis absent, however, during pregnancy, as well as during breastfeeding, it is prescribed only if indicated under medical supervision.
Overdose:
There are no data on cases of overdose of oral dosage forms of acetylcysteine.
Acetylcysteine, when taken at a dose of 500 mg / kg / day, does not cause signs and symptoms of overdose.
Symptoms: overdose can manifest with gastrointestinal symptoms such as nausea, vomiting and diarrhea.
Treatment: there is no specific antidote for acetylcysteine \u200b\u200bpoisoning, therapy is symptomatic.
Release form:
ACC 100, 200 - effervescent tablets 20 pcs.
ACC hot drink - hot drink powder for internal use - 200 mg (20 sachets) and 600 mg (6 sachets).
ACTS-Long - effervescent tablets (600 mg), 10 pcs. in a tube.
ACTS powder for preparation of solution for oral administration - 100, 200 mg, 2 pcs. packaged.
ACC for children - powder for preparation of a solution for internal administration of 30 g in a 75 ml vial (20 mg / ml) and 60 g in a 150 ml vial (20 mg / ml).
Storage conditions:
Out of the reach of children.
Temperature no more than 30 ° С.
The finished solution should be stored for no more than 12 days in the refrigerator (at a temperature of 2-8 ° C).
1 sachet (100 mg) of ACC granules for preparation of oral solution (orange) contains:
- excipients: ascorbic acid, sucrose, saccharin, orange flavor.
1 effervescent tablet (100 mg) ACC contains:
- active substance: acetylcysteine \u200b\u200b- 100 mg;
- excipients: citric acid anhydride - 679.85 mg, sodium bicarbonate - 291 mg, mannitol - 65 mg, ascorbic acid - 12.5 mg, lactose anhydride - 75 mg, sodium citrate - 0.65 mg, saccharin - 6 mg, blackberry flavor "B" - 20 mg.