Salazopyridazine application. Salazopyridazin: reviews, analogues, instructions where to buy
Title: Salazopyridazin International Name: Mesalazine (Mesalazine) Description active substance (MNN): Mesalazin Dosage Form: Rectal Suppositories, Suspension for Ingestion, Rectal Suspension, Tablets, Tablets Coated with Intestinal Shell, Tablets Prolonged Action Pharmacological Action: It has local anti-inflammatory (due to inhibition of neutrophilic lipoxygenase activity and PG and leukotriene synthesis). Inhibits migration, degranulation, phagocytosis of neutrophils, as well as IG secretion lymphocytes. It has an antibacterial effect on the intestinal sticks and some coccas (manifests itself in the thick intestine). It has an antioxidant effect (due to the ability to bind with free oxygen radicals and destroy them). It is characterized by good tolerability, reduces the risk of recurrence during Crohn's disease, especially in patients with Ileis and a large duration of the disease. Indications: Nonspecific ulcerative colitis, Crohn's disease (prevention and treatment of exacerbations). Contraindications: Hypersensitivity (when applied by enema, incl. To methyl and propylparaben), blood disease, ulcerative disease of the stomach and 12-rosewood, glucose-6-phosphate dehydrogenase deficiency, hemorrhagic diathesis, severe renal / liver failure, lactation period , last 2-4 weeks of pregnancy, childhood (up to 2 years) .c caution. Pregnancy (I trimester), hepatic and / or renal failure. Side effects: From the side digestive system: nausea, vomiting, heartburn, diarrhea, decline in appetite, abdominal pain, dry mouth, stomatitis, increasing the activity of "liver" transaminase, hepatitis, pancreatitis. From the side of the CSS: heartbeat, tachycardia, raising or decrease in blood pressure, painful pain, shortness of breath. From side nervous system: Headache, noise in ears, dizziness, polyneuropathy, tremor, depression. From the side of the urinary system: proteinuria, hematuria, oliguria, anuria, crystalluria, nephrotic syndrome. Allergic reactions: Skin rash, itching, dermatosis (pseudoeritromatosis), bronchospasm. From the side of the blood formation: Eosinophilia, anemia (hemolytic, megaloblastic, aplastic), leukopenia, agranulocytosis, thrombocytopenia, hypoprothrombinemia. Others: weakness, vapotitis, photosensibilization, lupus-like syndrome, oligospermia, alopecia, reducing the products of the tear fluid. Recently. Symptoms: nausea, vomiting, gastralgy, weakness, drowsiness. Treatment: stomach wash, appointment of laxative, symptomatic therapy. Method of application and dose: choice dosage form Determined by localization and length of intestinal lesion. With common forms, tablets are used, with distal (procts, proctus moves) - rectal forms. With exacerbation of the disease - 400-800 mg 3 times a day, within 8-12 weeks. For the prevention of relapses - at 400-500 mg 3 times a day with a non-specific ulcerative colitis and 1 g 4 times a day - during crown disease; Children over 2 years old - 20-30 mg / kg / day in several techniques, for several years. In case of severe disease, the daily dose can be increased to 3-4 g, but not more than 8-12 weeks. Tablets should be taken entirely, not chewing, after eating, drinking with plenty of liquid. Candles - 500 mg 3 times a day, and suspension - 60 g of suspension (4 g of Mesalazin) 1 time per day at night, in the form of medicinal microclizm (it is advised to clean the intestines). Children candles are prescribed at the rate: with exacerbation - 40-60 mg / kg / day; For supporting therapy - 20-30 mg / kg / day. special instructions: It is advisable to regularly hold general analysis blood (before the start, during, as well as after treatment) and urine, control over the excretory function of the kidneys. Patients who are "slow acetylubles" have an increased risk of developing side Effects. Can observe urine staining and tears in yellow-orange color, scraping soft contact lenses. In case of passing the drug intake, the missed dose should be taken at any time or together with the next dose. If several doses are missed, then without stopping treatment, consult a doctor. If you suspect the development of acute intolerance syndrome, Mesalazin must be canceled. Interaction: Strengthens the hypoglycemic effect of sulfonylurea derivatives, ulocogenicity GKS, toxicity of methotrexate, weakens the activity of furosemide, spiroranolactone, sulfonamides, rifampicin, enhances the effect of anticoagulants, increases the efficiency of uricurovuric LS (channel secretion blockers). Slows up the absorption of cyanocobalamin.
Before applying the medicinal preparation of Salazopyridazin, you must consult with your doctor. This manual is intended only for familiarization and is not intended to appoint treatment without the participation of a doctor.
Other drug preparations Antimicrobial and anti-inflammatory intestine
Mesalazin
Salazopyridazin :: Dosage form
rectal Suppositories, Suspension for Ingestion, Rectal Suspension, Tablets, Tablets Covered with Intestinal Shell, Prolonged Tablets
Salazopyridazin :: Pharmacological action
It has local anti-inflammatory (due to the inhibitory of neutrophilic lipoxygenase activity and PG and leukotriene synthesis). Inhibits migration, degranulation, phagocytosis of neutrophils, as well as IG secretion lymphocytes. It has an antibacterial effect on the intestinal sticks and some coccas (manifests itself in the thick intestine). It has an antioxidant effect (due to the ability to bind with free oxygen radicals and destroy them). It is characterized by good tolerability, reduces the risk of recurrence during Crohn's disease, especially in patients with Ileis and a large duration of the disease.
Salazopyridazin :: Indications
Nonspecific ulcerative colitis, Crohn's disease (prevention and treatment of exacerbations).
Salazopyridazin :: Contraindications
Hypersensitivity (when applied by enema, incl. To methyl and propylparaben), blood disease, ulcerative disease Stomach and 12-rosewood, glucose-6-phosphate dehydrogenase, hemorrhagic diathesis, severe renal / hepatic insufficiency, lactation period, last 2-4 weeks of pregnancy, children's age (up to 2 years) .c care. Pregnancy (I trimester), hepatic and / or renal failure.
Salazopyridazin :: Side effects
From the digestive system: nausea, vomiting, heartburn, diarrhea, decreased appetite, abdominal pain, dry mouth, stomatitis, increase in the activity of "liver" transaminase, hepatitis, pancreatitis. From the side of the CSS: heartbeat, tachycardia, raising or decrease in blood pressure, painful pain, shortness of breath. From the nervous system: headache, noise in ears, dizziness, polyneuropathy, tremor, depression. From the side of the urinary system: proteinuria, hematuria, oliguria, anuria, crystalluria, nephrotic syndrome. Allergic reactions: skin rash, itching, dermatosis (pseudoeritromatosis), bronchospasm. From the side of the blood formation: Eosinophilia, anemia (hemolytic, megaloblastic, aplastic), leukopenia, agranulocytosis, thrombocytopenia, hypoprothrombinemia. Others: weakness, vapotitis, photosensibilization, lupus-like syndrome, oligospermia, alopecia, reducing the products of the tear fluid. Recently. Symptoms: nausea, vomiting, gastralgy, weakness, drowsiness. Treatment: stomach wash, appointment of laxative, symptomatic therapy.
Salazopyridazine :: Method of application and dose
The choice of dosage form is determined by localization and length of intestinal lesion. With common forms, tablets are used, with distal (procts, proctus moves) - rectal forms. With exacerbation of the disease - 400-800 mg 3 times a day, within 8-12 weeks. For the prevention of relapses - at 400-500 mg 3 times a day with a non-specific ulcerative colitis and 1 g 4 times a day - during crown disease; Children over 2 years old - 20-30 mg / kg / day in several techniques, for several years. In case of severe disease, the daily dose can be increased to 3-4 g, but not more than 8-12 weeks. Tablets should be taken entirely, not chewing, after eating, drinking with plenty of liquid. Candles - 500 mg 3 times a day, and suspension - 60 g of suspension (4 g of Mesalazin) 1 time per day at night, in the form of medicinal microclizm (it is advised to clean the intestines). Children candles are prescribed at the rate: with exacerbation - 40-60 mg / kg / day; For supporting therapy - 20-30 mg / kg / day.
Salazopyridazin :: Special instructions
It is advisable to regularly carry out a general blood test (before starting, during, as well as after treatment) and urine, control over the excretory function of the kidneys. Patients who are "slow acetylubles" have an increased risk of developing side effects. It may be observed urine staining and tears in yellow-orange color, the scoke of soft contact lenses. In case of passing the drug intake, the missed dose should be taken at any time or together with the next dose. If several doses are missed, then without stopping treatment, consult a doctor. If you suspect the development of acute intolerance syndrome, Mesalazin must be canceled.
Salazopyridazin :: Interaction
Enhances the hypoglycemic effect of sulfonylurea derivatives, ulcerogenicity GKS, the toxicity of methotrexate, weakens the activity of furosemide, spiroranolactone, sulfonilahminamides, rifampicin, enhances the effect of anticoagulants, increases the efficiency of uricozeuric LS (channel secretion blockers). Slows up the absorption of cyanocobalamin.
International Name
Mesalazine (Mesalazine)Group Affiliation
Antimicrobial and anti-inflammatory intestineDosage form
Rectal Suppositories, Suspension for Ingestion, Rectal Suspension, Tablets, Tablets Covered with Intestinal Shell, Prolonged Tabletspharmachologic effect
It has local anti-inflammatory (due to the inhibitory of neutrophilic lipoxygenase activity and PG and leukotriene synthesis). Inhibits migration, degranulation, phagocytosis of neutrophils, as well as IG secretion lymphocytes. It has an antibacterial effect on the intestinal sticks and some coccas (manifests itself in the thick intestine).
It has an antioxidant effect (due to the ability to bind with free oxygen radicals and destroy them). It is characterized by good tolerability, reduces the risk of recurrence during Crohn's disease, especially in patients with Ileis and a large duration of the disease.
Indications
Nonspecific ulcerative colitis, Crohn's disease (prevention and treatment of exacerbations).Contraindications
Hypersensitivity (when applied by enema, incl. To methyl and propylparaben), blood disease, ulcerative disease of the stomach and 12-risen, glucose-6-phosphate dehydrogenase deficit, hemorrhagic diathesis, severe renal / hepatic insufficiency, lactation period, last 2-4 weeks of pregnancy, children's age (up to 2 years) .c care. Pregnancy (I trimester), hepatic and / or renal failure.Side effects
From the digestive system: nausea, vomiting, heartburn, diarrhea, decreased appetite, abdominal pain, dry mouth, stomatitis, increase in the activity of "liver" transaminase, hepatitis, pancreatitis.
From the side of the CSS: heartbeat, tachycardia, raising or decrease in blood pressure, painful pain, shortness of breath.
From the nervous system: Headache, noise in ears, dizziness, polyneuropathy, tremor, depression.
From the side of the urinary system: proteinuria, hematuria, oliguria, anuria, crystalluria, nephrotic syndrome.
Allergic reactions: skin rash, itching, dermatosis (pseudoeritromatosis), bronchospasm.
From the side of the blood formation: Eosinophilia, anemia (hemolytic, megaloblastic, aplastic), leukopenia, agranulocytosis, thrombocytopenia, hypoprothrombinemia.
Others: weakness, vapotitis, photosensibilization, lupus-like syndrome, oligospermia, alopecia, reduction of tear fluid products.
Application and dosage
The choice of dosage form is determined by localization and length of intestinal lesion.
With common forms, tablets are used, with distal (procts, proctus moves) - rectal forms. With exacerbation of the disease - 400-800 mg 3 times a day, within 8-12 weeks. For the prevention of relapses - at 400-500 mg 3 times a day with a non-specific ulcerative colitis and 1 g 4 times a day - during crown disease; Children over 2 years old - 20-30 mg / kg / day in several techniques, for several years. In case of severe disease, the daily dose can be increased to 3-4 g, but not more than 8-12 weeks. Tablets should be taken entirely, not chewing, after eating, drinking with plenty of liquid.
Candles - 500 mg 3 times a day, and suspension - 60 g of suspension (4 g of Mesalazin) 1 time per day at night, in the form of medicinal microclizm (it is advised to clean the intestines).
Children candles are prescribed at the rate: with exacerbation - 40-60 mg / kg / day; For supporting therapy - 20-30 mg / kg / day.
special instructions
It is advisable to regularly carry out a general blood test (before starting, during, as well as after treatment) and urine, control over the excretory function of the kidneys. Patients who are "slow acetylubles" have an increased risk of developing side effects. It may be observed urine staining and tears in yellow-orange color, the scoke of soft contact lenses. In case of passing the drug intake, the missed dose should be taken at any time or together with the next dose. If several doses are missed, then without stopping treatment, consult a doctor. If you suspect the development of acute intolerance syndrome, Mesalazin must be canceled.Interaction
Enhances the hypoglycemic effect of sulfonylurea derivatives, ulcerogenicity GKS, the toxicity of methotrexate, weakens the activity of furosemide, spiroranolactone, sulfonilahminamides, rifampicin, enhances the effect of anticoagulants, increases the efficiency of uricozeuric LS (channel secretion blockers). Slows up the absorption of cyanocobalamin.Drug reviews Salazopyridazin: 0
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Do you use salazopyridazine, as analog or vice versa, his analogues?nEARMAKOPY DEPARTMENT 5- (P - Phenylazo) -Salicylic acid
Description: Orange powder without smell.
Solubility: Virtually insoluble in water, a little soluble in alcohol, ether and chloroform, easily soluble in DMF (dimethylformamide) and sodium hydroxide solution.
Authenticity: 1) When interacting with a solution of copper sulfate, a precipitate is formed green colour. 2) a private reaction in the presence in the nitrogen molecule - the hydrogenation reaction: zinc dust and concentrated chloride acid are added to the salasopyridazine solution. Orange solution of the solution is gradually discolored. FS recommends that Identification in the visible part of the spectrum of 400-600 nm; So the drug has a maximum of 457 nm when using a solvent 0.1 M sodium hydroxide solution. At this wavelength, a quantitative definition can be carried out.
Purity: According to the FS method of TLC on the "Silufol UV-254" plates in comparison with the substance witness. The stain must be one. The microbiological purity of the drug according to GFXI, B is established. 2, p. 193.
Quantitation: Polarography method. Polarographs in DMF solution. Calibration graphics. It is possible to use bromometry and neutralization method for carboxyl group and phenolic hydroxyl in the DMF medium. Trant is a non-aqueous solution of sodium hydroxide.
Storage:
Application: An antibacterial effect in the intestine, where the molecule is cleavage to sulfapyridazine and 5-aminosalicylic acid, which have an antibacterial effect in the treatment of non-specific ulcerative colitis.
Form release: Powder, tablets of 0.5 g, 5% suspension in 250 ml bottles, candles.
CO-TRIMOXAZOLE (BISEPTOL). Ko-Trimoxazole (Biseptol)
nEARMAKOE DEPARTMENT
Ingredients: in sulfamethoxazole tablet 0.4 g and trimethopris 0.08 g:
Description: pills white color With a cream tint.
Authenticity: Definition is carried out after shaking 3 minutes of powder with a raster half of a tablet with 5 ml of 0.1 M sodium hydroxide solution and 20 ml of water purified. 1) the suspension is filtered and a solution of copper sulfate (II) is adhered to the filtrate; A yellowish-greenish sediment of the copper salt of sulfamethoxazole is formed. 2) The filtrate gives a pharmacopoeial reaction of the formation of azocracy to primary aromatic amines (with β-naftol). The sulfonamide component of the drug gives other characteristic authenticity responses for sulfanimamides. You can use the UV spectrum to identify, which has a maximum absorption at a wavelength of 246 nm.
The TLC on the plates of Kizelgel is chromatographed in the movable phase chloroform-methanol-solution of ammonia concentrated (80: 20: 3); The manifestation is carried out by the reagent of dragantorf - two stains at the level of witness substances should appear. The presence of impurities determined by this method should not exceed 1%; The presence of strepticide is also determined (no more than 0.5%) and sulfanyl acid (no more than 0.3%).
quantitation: FS sulfamethoxazole is determined by nitritometrically. Indicator - iodcrachmal paper (or potentiometrically). Timetoprix is \u200b\u200bdetermined by the method of non-aqueous titration in the medium of ice acetic acid and acetic anhydride. Titrant - 0.1 M hydrochloric acid solution, indicator - crystalline purple.
Storage: List b; In the light-protected place.
Application: antibacterial agent For the treatment of diseases respiratory tract, urinary tract and gastrointestinal tract.
Release form: Tablets for adults called "Ko-Trimoxazole-480" and for children "co-trimoxazole-240 (and 120)"; Syrup for children.
Sulfatonum. Sulfaton
nEARMAKOE DEPARTMENT
Soviet Preparation similar to pharmacological action Co-trimoxazole, but having a sulfonamide component of sulfonimetoxin 0.25 g and trimethopril 0.1 g. Higher antibacterial activity of sulfonimetoxin allows the drug in a smaller dosage, which reduces possible side effects.
Benzothiadiazin derivatives
The condensed system of benzothiadiazine includes the benzo-1,3-diazine core, and the basis of the structure medicines This group is 1,2,4-benzothiadiazine-1,1-dioxide:
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These derivatives have a diuretic effect, but a more pronounced effect has 3,4-dihydro-produced benzothiadiazine with the general formula:
At the moment in medical practice Apply drug hydrochlorothiazide (dichloatiazide).
The price of the drug in different pharmacies may vary.
INTERNATIONAL NAME
Mesalazine (Mesalazine)
Pharmacological group
Antimicrobial and anti-inflammatory intestinal agent (12)
Active substances
Mesalazin
Dosage form
rectal Suppositories, Suspension for Ingestion, Rectal Suspension, Tablets, Tablets Covered with Intestinal Shell, Prolonged Tablets
Farm. Evidence
It has local anti-inflammatory (due to the inhibitory of neutrophilic lipoxygenase activity and PG and leukotriene synthesis). Inhibits migration, degranulation, phagocytosis of neutrophils, as well as IG secretion lymphocytes. It has an antibacterial effect on the intestinal sticks and some coccas (manifests itself in the thick intestine). It has an antioxidant effect (due to the ability to bind with free oxygen radicals and destroy them). It is characterized by good tolerability, reduces the risk of recurrence during Crohn's disease, especially in patients with Ileis and a large duration of the disease.
Using
Nonspecific ulcerative colitis, Crohn's disease (prevention and treatment of exacerbations).
Contraindications for use
Hypersensitivity (when applied by enema, incl. To methyl and propylparaben), blood disease, ulcerative disease of the stomach and 12-risen, glucose-6-phosphate dehydrogenase deficit, hemorrhagic diathesis, severe renal / hepatic insufficiency, lactation period, last 2-4 weeks of pregnancy, children's age (up to 2 years) .c care. Pregnancy (I trimester), hepatic and / or renal failure.
Possible side effects
From the digestive system: nausea, vomiting, heartburn, diarrhea, decreased appetite, abdominal pain, dry mouth, stomatitis, increase in the activity of "liver" transaminase, hepatitis, pancreatitis. From the side of the CSS: heartbeat, tachycardia, raising or decrease in blood pressure, painful pain, shortness of breath. From the nervous system: Headache, noise in ears, dizziness, polyneuropathy, tremor, depression. From the side of the urinary system: proteinuria, hematuria, oliguria, anuria, crystalluria, nephrotic syndrome. Allergic reactions: skin rash, itching, dermatosis (pseudoeritromatosis), bronchospasm. From the side of the blood formation: Eosinophilia, anemia (hemolytic, megaloblastic, aplastic), leukopenia, agranulocytosis, thrombocytopenia, hypoprothrombinemia. Others: weakness, vapotitis, photosensibilization, lupus-like syndrome, oligospermia, alopecia, reducing the products of the tear fluid. Recently. Symptoms: nausea, vomiting, gastralgy, weakness, drowsiness. Treatment: stomach wash, appointment of laxative, symptomatic therapy.
Doses and method of application
The choice of dosage form is determined by localization and length of intestinal lesion. With common forms, tablets are used, with distal (procts, proctus moves) - rectal forms. With exacerbation of the disease - 400-800 mg 3 times a day, within 8-12 weeks. For the prevention of relapses - at 400-500 mg 3 times a day with a non-specific ulcerative colitis and 1 g 4 times a day - during crown disease; Children over 2 years old - 20-30 mg / kg / day in several techniques, for several years. In case of severe disease, the daily dose can be increased to 3-4 g, but not more than 8-12 weeks. Tablets should be taken entirely, not chewing, after eating, drinking with plenty of liquid. Candles - 500 mg 3 times a day, and suspension - 60 g of suspension (4 g of Mesalazin) 1 time per day at night, in the form of medicinal microclizm (it is advised to clean the intestines). Children candles are prescribed at the rate: with exacerbation - 40-60 mg / kg / day; For supporting therapy - 20-30 mg / kg / day.
Other instructions
It is advisable to regularly carry out a general blood test (before starting, during, as well as after treatment) and urine, control over the excretory function of the kidneys. Patients who are "slow acetylubles" have an increased risk of developing side effects. It may be observed urine staining and tears in yellow-orange color, the scoke of soft contact lenses. In case of passing the drug intake, the missed dose should be taken at any time or together with the next dose. If several doses are missed, then without stopping treatment, consult a doctor. If you suspect the development of acute intolerance syndrome, Mesalazin must be canceled.
Interaction
Enhances the hypoglycemic effect of sulfonylurea derivatives, ulcerogenicity GKS, the toxicity of methotrexate, weakens the activity of furosemide, spiroranolactone, sulfonilahminamides, rifampicin, enhances the effect of anticoagulants, increases the efficiency of uricozeuric LS (channel secretion blockers). Slows up the absorption of cyanocobalamin.
Draw your attention to! Before applying any medicinal preparations You must consult with your doctor!