Pentalgin - ISN. Pentalgin-ICN - Description of the drug, application instructions, Pentalgin-ICN reviews Application for pregnancy and children

General characteristics. Structure:

Active substances: 300 mg of sodium metamizole, 300 mg of paracetamol, 50 mg of caffeine (in terms of dry substance), 8 mg of phosphate codein (in terms of dry substance), 10 mg of phenobarbital.

Auxiliary substances: Potato starch, povidone (low molecular weight polyvinylpyrrolidone), stearin acid, calcium stearate.

Pharmacological properties:

Pharmacodynamics. Combined drugIt has an analgesic, antipyretic, controversial action.

Paracetamol - nonarcotical analgesic; Blocks cyclooxygenase mainly in the CNS, affecting the centers of pain and thermoregulation; It has an analgesic and antipyretic effect.

Sodium metamizole is a non-steroidal anti-inflammatory agent, which has a pronounced analgesic effect.

Caffeine improves the well-being of patients and reduces headache Vascular genesis (including).

Phenobarbital increases the analgesic efficacy of sodium metamizol and paracetamol.

Codein - has an anesthetic effect due to the excitation of opiate receptors in various parts of the central nervous system, leading to the stimulation of the antinocyptive system and the change in the emotional perception of pain.

Indications for use:

Pentalgin®-ICN is used with painful syndrome of various genesis of weak and average intensity (including with pains in joints, muscles, radiculitis, menstrual pains, neuralgias, head and toothpins).

Pentalgin®-ICN can be used in colds accompanied by feverish syndrome.

Important! Get acquainted with treatment

Method of use and dose:

The drug usually take 1 tablet 1-3 times a day. Maximum daily dose - 4 tablets.

The drug should not take more than 5 days as an anesthetic agent and more than 3 days as an antipyretic remedy without appointing and observing the doctor.

Features of application:

With long-term (more than 1 week) treatment requires control of the picture of peripheral blood and functional state Liver. Can change the results of drug control analyzes athletes.

It makes it difficult to establish a diagnosis with acute abdominal pain syndrome. In patients suffering from atopic bronchial asthma, half ancient, there is an increased risk of developing hypersensitivity reactions.

Impact on the ability to control the transc. cf. And fur.In connection with the possibility of developing a sedative action, during treatment it is not recommended to manage vehicles and in-prone other potentially hazardous species Activities requiring increased concentration of attention, the speed of psychomotor and motor reactions.

Side effects:

Allergic reactions (rash, itching,), drowsiness, heartbeat ,; .

With a long-term uncontrolled reception in high doses - addictive (weakening of an anesthetic effect), drug dependence (codeine); Hepatic and / or renal failure.

Interaction with other drugs:

With the simultaneous use of funds that have an inner influence on the central nervous system (including sedatives and tranquilizers) is likely to enhance severity sedative effect and hijackers to the respiratory center.

Enhances the effect of ethanol on a psychomotor reaction.

Sodium metamizole reduces cyclosporine concentration.

Sodium metamizole, displacing oral hypoglycemic drugs due to protein, indirect anticoagulants, glucocorticosteroids and indomethacin, increases their activity. Tricyclic antidepressants, contraceptive agents for intake, allopurinol on the metamizole metamizole metabolism in the liver and increase its toxicity.

The simultaneous use of the drug with other non-tarcotic analgesics can lead to amplification of toxic effects.

Barbiturates, phenylbutazone and other inductors of liver microsomal enzymes weaken the action of metamizole.

Contraindications:

Hypersensitivity, heavy hepatic and / or

Codeine + caffeine + sodium metamizole * + paracetamol * + phenobarbital * (Codeine + Caffeine + Metamizole Sodium * + ParaceTamol * + PhenobarBital *)

Last update of description by the manufacturer

Latin name

Pentalgin-ICN.

ATX

N02BB72 Sodium metamizole in combination with psychotropic drugs

Pharmacological group

Nonological Classification (ICD-10)

• G43 Migrain
• J06. Acute infections Upper respiratory tract multiple and unspecified localization
• K08.8.0 * pain
• M25.5 pain in the joint
• M79.1 Malgy
• M79.2 Neuralgia and Neuritis Uncomfortable
• N94.6 Dysmenorrhea Uncomfortable
• R50 fever unclear origin
• R51 Headache
• R52.2 Other Permanent Pain

Composition and form of release

1 tablet contains sodium and paracetamol metamizole 0.3 g, caffeine 0.05 g, phosphate codeine 0.008 g and phenobarbital 0.01 g; In the contour cell pack 10 pcs., in a cardboard pack 1 or 2 packs or 12 pcs., in a cardboard pack 1 package.

pharmachologic effect

Pharmacological action is analgesic, antipyretic, anti-inflammatory.

Inhibits cyclooxygenase and inhibits the biosynthesis of PG (analgin and paracetamol), stimulates opiate receptors, activates the antinocyptive system (codeine). Inhibits (sedative effect) CNS (phenobarbital). Caffeine increases the permeability of histohematic membranes and increases the concentration of other components in the CNS.

Indications

Moderately pronounced pain syndrome: pain head and dental, migraine, neuralgia, myalgia, arthralgia, primary dysmenorrhea; fever.

Contraindications

Hypersensitivity (incl. To individual components), pulmonary failure, acute attack Bronchial asthma, respiratory disorder due to the oppression of the respiratory center, violation of the functions of the liver and / or kidney.

Application in pregnancy and breastfeeding

Contraindicated during pregnancy. At the time of treatment, breastfeeding should be stopped.

Side effects

From side nervous system and sense organs: drowsiness, lethargy, lowering attention concentration.

From side of cardio-vascular system and blood (blood formation, hemostasis): granulocyptopenia, agranulocytosis.

From the head of the gastrointestinal bodies: dyspeptic phenomena, pain in the epigastric region, erosive-ulcerative lesions of the gastrointestinal tract.

Allergic reactions: skin rash.

Interaction

Enhances the oppressive effect of ethanol on the CNS.

Method of application and dose

Inside - 1 table. 1-3 times a day. The course of treatment depends on the effectiveness of therapy and, as a rule, does not exceed 5 days.

Precautions

For long use It is necessary to control the composition of peripheral blood. Avoid simultaneous alcohol intake.

Pentalgin-ICN. Tablets - packaging Contour cell 12, pack cardboard 1- code EAN: 4601669001443- № P N000343 / 01, 2010-07-02 from Farmstandart-Lexes (Russia)

Latin name

Pentalgin-ICN.

Active substance

Codeine Caffeine Metamizole Sodium * Paracetamol * Phenobarbital * (Codeinum Coffeinum Methamizolum Natrium ParaceTamolum Phenobarbitalum)

ATX

N02BB72 Sodium metamizole in combination with psychotropic drugs

Pharmacological group

NSAIDs - Pyrazolones in combination

Nonological Classification (ICD-10)

G43 MigraineJ06 Acute infections of the upper respiratory tract of multiple and unspecified localizationK08.8.0 * Pain dentalm25.5 pain in the jointM79.1 Maalgiam79.2 Neuralgia and neuritis uncomfortableN94.6 Dysmenorrhea UncleanR50 Frequency of obscure originR51 Head painr52.2 Other constant pain

Composition and form of release

1 tablet contains sodium metamizole and paracetamol 0.3 g, caffeine 0.05 g, phosphate codeine 0.008 g and phenobarbital 0.01 g - in contour cellular packs 10 pcs., In a cardboard pack 1 or 2 packs or 12 pcs., In a cardboard pack 1 package.

pharmachologic effect

Pharmacological action - analgesic, antipyretic, anti-inflammatory.

Inhibits cyclooxygenase and inhibits the biosynthesis of PG (analgin and paracetamol), stimulates opiate receptors, activates the antinocyptive system (codeine). Inhibits (sedative effect) CNS (phenobarbital). Caffeine increases the permeability of histohematic membranes and increases the concentration of other components in the CNS.

Indications Pentalgin-ICN

Moderately expressed pain syndrome: pain head and dental, migraine, neuralgia, myalgia, arthralgia, primary dysmenorrhea.

Contraindications

Hypersensitivity (including to individual components), pulmonary failure, acute attack of bronchial asthma, disruption of breathing due to the oppression of the respiratory center, violating the functions of the liver and / or kidney.

Application in pregnancy and breastfeeding

Contraindicated during pregnancy. At the time of treatment, breastfeeding should be stopped.

Side effects

On the part of the nervous system and the senses: drowsiness, lethargy, decrease in the concentration of attention.

From the side of the cardiovascular system and blood (blood formation, hemostasis): granulocytopenia, agranulocytosis.

From the head of the gastrointestinal bodies: dyspeptic phenomena, pain in the epigastric region, erosive-ulcerative lesions of the gastrointestinal tract.

Allergic reactions: skin rash.

Interaction

Enhances the oppressive effect of ethanol on the CNS.

Method of application and dose

Inside - 1 table. 1-3 times a day. The course of treatment depends on the effectiveness of therapy and, as a rule, does not exceed 5 days.

Precautions

With prolonged use, it is necessary to control the composition of peripheral blood. Avoid simultaneous alcohol intake.

Storage Conditions Pentalgin-ICN

In a dry, protected from light place.

Keep out of the reach of children.

The shelf life of Pentalgin-ICN

3 years.

Last update of description by the manufacturer

01.07.2002

Other preparation options for Pentalgin-ICN.

Pentalgin-ICN Tablets - Packaging Contour Cell 10, Putlets Cardboard 1- Code EAN: 4601669000927- № P N000343 / 01, 2010-07-02 From Farmstandart-Lexere (Russia) Pentalgin-ICN Tablets- Packaging Contour Cell 10, Putting Cardboard 2 - EAN code: 4601669000910 - № P N000343 / 01, 2010-07-02 from Farmstandart-Lexes (Russia) Pentalgin-ICN Tablets- Packaging Contour Cellular 12, Package Cardboard 1- Code EAN: 4601669001443- 2010, 2010 -07-02 From Farmstandart-Lexere (Russia) Pentalgin-ICN Tablets- Packaging Contour Cellular 12, Putting Cardboard 2-2 No. P N000343 / 01, 2010-07-02 from Farmstandart-Lexes (Russia) Pentalgin-ICN Tablets - Contour Packaging Cell 6, pack cardboard 1- № P N000343 / 01, 2010-07-02 From Pentalgin-ICN Pentalgin-ICN Packaging Contour cells 6, Package Cardboard 2- No. P N000343 / 01, 2010-07-02 From Pentalgin-ICN Pentalgin-ICN (Russia) Pentalgin-ICN Packaging Contour Cellular 10, Cardboard Box 500-2 No. P N000343 / 01, 201 0-07-02 from Farmstandart-Lexes (Russia) Pentalgin-ICN Tablets- Packaging Contour Cellular 12, Box Cardboard 500-2 No. P N000343 / 01, 2010-07-02 from Farmstandart-Lexes (Russia) Pentalgin-ICN Tablets- Packaging Contour cell 6, cardboard box 500- № P N000343 / 01, 2010-07-02 from Farmstandart-Lexere (Russia)

Dosage form: & nbsptablets Composition:

Active substances: Sodium metamizol -300 mg, paracetamol - 300 mg, caffeine (in nereceiver on dry matter) - 50 mg, Codeinaphosphate (in terms of dry matter) -8 mg, phenobarbital -10 mg;

excipients: Starch Katofeld - 120 mg, Pisidone (Polyvinylpyrrollon low molecular weight medical) - 4 mg, acid stearin - 4 mg, calcium stearate - 4 mg.

Description:

Tablets from white to white with a yellow or cream tint of color, double-screwed capsule with flat side surfaces, with risk on one side and engravingPentalgin to another.

Pharmacotherapeutic Group:Analgesizing agent (analgesiugsya opioid means + npvp + analgesyruyugzay nonarcotic agent + psychostimulating media - in + barbituat) ATH: & NBSP

Sodium metamizol in combination with psycholes

Pharmacodynamics:

The combined drug, has an analgesic, antipyretic, controversial action.

Paracetamol - nonarcoctic analgesic; Blocks cyclooxygenase mainly in the CNS, affecting the centers of pain and thermoregulation; It has an analgesic and antipyretic effect. - Nonteroid anti-inflammatory agent, which has a pronounced analgesic effect. Improves the well-being of patients and reduces the headache of vascular genesis (including migraine). Increases the analgesic efficacy of sodium and paracetamol metamizol. It has an analgesic effect due to the excitation of opiate receptors in various parts of the central nervous system, leading to stimulation of the antinoceceptive system and the change in the emotional perception of pain.

Pharmacokinetics: Indications: Pentalgin®-Inc is used with pain syndrome of various genesis of weak and average intensity (including with pains in joints, muscles, radiculitis, menstrual pains, neuralgias, head and dental pains).

"Pentalgin ®-INC "can be used in colds accompanied by feverish syndrome.

Contraindications:

Hypersensitivity, heavy hepatic and / or renal failure, bronchial asthma, glucose-6-phosphate dehydrogenase deficit; anemia, leukopenia; states accompanied by inhibition of breathing; Card-brain hypertension, acute infarction myocardium; arrhythmia, alcoholic intoxication, glaucoma, pregnancy, lactation period, childhood (up to 12 years).

Carefully:Ulcer of the stomach and duodenal gut (in the remission stage) elderly age, arterial hypertension. Pregnancy and lactation:Contraindicated. Method of use and dose:The drug usually take 1 tablet 1-3 times a day. Maximum daily dose - 4 tablets. The drug should not take more than 5 days as an anesthetic and more than 3 days as antipyretic remedy without appointing and observing the doctor. Side effects:

Allergic reactions (rash, itching, urticaria), dizziness, drowsiness, heartbeat, tachycardia, nausea, vomiting, constipation; leukopenia, granulocyptopenia, agranulocytosis. With long-term uncontrolled reception in high doses - addictive (weakening of an anesthetic effect), drug addiction (); Hepatic and / or renal failure.

Overdose: Nausea, vomiting, gastralgy, tachycardia, arrhythmia, oppression of the respiratory center. It is shown to wash the stomach, the purpose of intestinal adsorbents, if necessary, conducting symptomatic therapy. Interaction:

With the simultaneous use of funds that have an inoperative effect on the central nervous system (including sedatives and tranquilizers) is likely to enhance the sedimentation of the sedative effect and the oppressive effect on the respiratory center.

Enhances the effect of ethanol on a psychomotor reaction.

Sodium metamizole reduces cyclosporine concentration.

Sodium metamizol, displacing oral hypoglycemic drugs due to protein, indirect anticoagulants, glucocorticosteroids and increases their activity. Tricyclic antidepressants, contraceptive means for intake, violate metamizole metamizole metabolism in the liver and increase its toxicity.

The simultaneous use of the drug with other non-tarcotic analgesics can lead to amplification of toxic effects.

Barbiturates, and other inductors of the microsomal liver enzymes weaken the action of metamizole.

Special instructions:

With long-term (more than 1 week) treatmentpicture control of periphericblood and functional stateliver.Can change the results of testsping control of athletes. Makes it difficult to establish a diagnosis with acute abdominal pain syndrome. In patients suffering from atopic bridgeaustma, half ancondes, is availableleague Risk Development of Hyperchow Reactions.

Impact on the ability to control the transc. cf. And Meh.:

In connection with the possibility of sedative action, during treatment it is not recommended to manage vehicles and engage in other potentially hazardous activities that require increased concentrations of attention, the speed of psychomotor and motor reactions.

This drug is used not only as a strong analgesic, but also as an antipyretic and anti-inflammatory agent.

Pentalgin ICN. Effectively copes with any kind of pain, has a light soothing and anticonvulsant action.

The main purpose of the drug is the removal of muscle and articular pain, migraine.

Due to its composition, Pentalgin has a powerful integrated effect, preventing the development of prostaglandins by blocking cyclooxygenase.

This is the name of a special enzyme directly involved in the development of inflammation, which, in turn, is divided into two separate forms (COF-1 and COF-2).

Pentalgin ICN has wide effect On both forms of the enzyme cyclooxygenase, which implies its use in the therapy of a huge number of pathologies.

Instructions for use

Despite the fact that the drug is nevertheless, and it can be easily bought in any pharmacy, it is not necessary to use it without appointing a doctor. It has a lot of contraindications and causes negative reactions of the body.

That is why it is necessary to take it only in case of extreme necessity, and strictly on the council of a specialist. Before use, it is necessary to carefully examine the instructions for the drug, but to avoid trouble, will help compliance with the correct dosage and treatment regimen.

Therapeutic action

The medication includes 5 active ingredients at once, which gives it the widest range of action. This causes its anesthetic opioid and psychostimulating effect.

The preparation paracetamol, ensures the removal of fever, lowers the temperature, and barbituat Phenobarbital, increases the effectiveness of paracetamol and metamizola.

Caffeine ensures psychostimulation, expands the vessels, eliminates the attacks of migraine, and codeine Opioid receptors of the nervous system excites the emotional perception of pain.

Composition and form of release

The drug is produced by the Russian company Farmstandard and is available only In the form of tablets oblong shape, white or light cream color. On one side there is an inscription Pentalgin, and on the other - a transverse strip that dividing the tablet in half.

Each tablet contains:

As auxiliary components in medicine Potato starch, calcium stearate, poveney and stearic acid are included.

Indications

Pentalgin ICN is prescribed for colds and viral diseases, accompanied by fever and high temperatures.

Main reading for use:

• pain syndrome at various lesions of the joints;
• malgy;
• toothache;
• migraine;
• neuralgia;
• headaches of unclear origin;

Often, the drug is used with algodismenium (menstrual pain), but only after consulting with the doctor.

Dosage and method of application

The maximum daily dose of the drug should not exceed 4 tablets. Standard dosage involves taking medication, at the rate of 1 tablet three times a day. As an antipyretic agent, Pentalgin ICN does not take longer than 3 days, and for pain relief, the course of therapy continues only for 5 days. The duration of treatment is determined by the doctor, based on the patient's condition.

Medicinal interaction

Do not take Pentalgin together with sedative sedativesproviding an oppressive effect on the central nervous system to avoid breathing problems and violations of the internal organs.

Forbidden sharing with indomethacin, cyclosporine antibiotics, hypoglycemic drugs, anticoagulants Indirect action.

Some antidepressants, Allopurinol, oral contraceptives, increase the toxic effect on the liver, which is part of the drug of metamizole.

The same effect will be observed at simultaneous reception With any nonopetic anesthetics, and barbiturates, on the contrary, weaken metamizole efficiency.

Side effects

Like any combined analgesic, Pentalgin ICN is capable of calling a large number of Adverse reactions.

Related to them:

• dizziness;
• violation of the rhythm of the heart;
• lethargy and drowsiness;
• leukopenia;
• constipation;
• agranulocytosis;
• vomiting;
• granulocytopenia.

Often, the drug contributes to the development of serious allergic reactions, in the form of skin rashes, urticaria, and sometimes swelling quinque.

Overdose

It is important to know that long, uncontrolled drug causes addiction and severe drug addiction. The reason for the composition of the tablet and phenobarbital is the reason. In addition, the use of the drug longer than 5 days, contributes to the development of tachycardia, violation of the activity of liver cells, changes in psychosomatic reactions.

The one-time adoption of a large dose of the drug leads to the emergence of nausea and vomiting, arrhythmia, the increase in heartbeat and oppression of breathing, gastralgia. There is no specific treatment in this case, but only washing the stomach, the use of sorbents and symptomatic therapy applies.

Contraindications

Do you know that ...

Next fact

Pentalgin ICN is pretty heavy drughaving a large number of contraindications.

The main are:

• ulcers of the gastrointestinal bodies;
• heart pathology;
• intracranial pressure;
• glaucoma;
• hypertension;
• acute heart attack;
• anemia;
• bronchospasm and respiratory diseases;
• blood breeding.

It is impossible to combine tablets with alcohol, or take them in the presence of individual intolerance.

Pregnancy and lactation

Pentalgin ICN is strictly contraindicated during pregnancy and lactation, since its active ingredients penetrate the placenta to the fetus and in breast milk When feeding. This can lead to irreparable consequences for the health of the child.

special instructions

It is not necessary to use this drug professional athletes to important competitions in order to avoid a positive result of doping sample. Reception of the drug longer than the week requires control of the composition of the blood and liver function. It is impossible to use medicine for the treatment of patients with asthma, allergic pollinosis and acute abdominal pain.

Impact on the ability to driving transport

Pentalgin is capable not only to cause dizziness and drowsiness, but also to influence the speed of psychomotor reactions. This requires special caution, refusing to manage vehicles and work related to hazardous activities.

Children

The Pentalgin ICN preparation is not appointed for the treatment of children under 12, and older children, it is allowed to apply only under the control of the doctor.

Diseases of kidneys

The medicine is strictly contraindicated with severe renal failure. Light kidney pathology requires a dose adjustment and specialist observation.

Laughing liver

It is impossible to use a drug with severe disorders in the work of the liver, liver failure, any kind of hepatitis and cirrhosis. In other cases, the drug is taken with caution.

Storage conditions

The preparation is subject to storage at room temperature, in a dark and dry place. The shelf life will be no more than 3 years from the date of manufacture.

Price

You can buy pentalgin in any pharmacy at a fairly affordable price that does not depend on the form of property and the price category of the pharmacy network. In the regions, the drug will cost somewhat cheaper, and in the capital - just more expensive.

Terms of sale

To buy this medicinal product, the recipe from the doctor is not required. It is in free sale, but without appointing a doctor, it is better not to use it. The drug has many contraindications and negative reactions, which requires caution in use.

Cost in Russia

Here, to purchase Pentalgin ICN can be on average for 140-170 rubles. So much will cost a package consisting of 12 tablets.

Price in Ukraine

In this country, it is possible to buy a drug of Russian production 180-200 hryvnia For 24 tablets. Pentalgin, made in Ukraine, will cost much cheaper, about 20-25 hryvnia for packaging.

Analogs

Absolutely similar in the composition of drugs in the world does not exist, but there are medicines similar to the principle of action.

The most popular analogues are considered:

All these drugs have a similar anesthetic effect, but differ in composition.

Video: " Effective means From pain: titles and descriptions "