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Amoxiclav 875 125 side effects. Amoxiclav: instructions for use, analogues and reviews, prices in pharmacies in Russia

The entire world around us is swarming with pathogens. Fortunately, every person's body has one very pleasant feature. If everything is in order with the immune system, the skin and mucous membranes are not damaged, there is no need to be afraid of a bacterial or any other infection. Otherwise, you will have to find out what amoxiclav is, what it helps from and when this drug is prescribed.

The importance of the microflora of the internal environment

In the human body, normal microflora is constantly present, but sometimes it can be replaced by pathogenic flora and conditionally pathogenic, which can lead to the development of the disease.

Normal

Pathogenic

It begins to populate the child's body from the first minutes of life, from the moment the baby is laid out on the mother's belly.

It is constantly present in the environment, penetrates, as a rule, into a weakened organism.

It is part of the body's immune system and ensures normal digestion.

It actively multiplies and releases toxins that can cause headaches.

In its absence, a diagnosis is made and therapy is carried out aimed at colonizing the internal environment with microbes.

In addition to intoxication, pathogenic microflora leads to the development of infectious diseases.

So it is necessary to fight only with those microorganisms that can cause serious diseases. The destruction of normal microflora will lead to a weakening of the body, digestive disorders and an increased risk of penetration of harmful microbes.

Amoxiclav: instruction, price

Since the drug is, its appointment and use should be monitored by the attending physician:

  • The minimum course of taking the drug is 5 days, at a shorter time, the tablets will not have the desired effect and will not be able to destroy all forms of pathogenic bacteria;
  • The duration of the maximum course should not exceed two weeks, due to possible side effects. After taking the drug for two weeks, you must again be examined by a doctor in order to receive further recommendations;
  • The dose for children under 12 years of age is calculated based on weight. For each kilogram of body weight, 40 mg per day is prescribed, the entire dose is evenly distributed over three doses;
  • The dosage for adults depends on general condition organism and the degree of progression of the disease. Tablets are used 2 or 3 times a day, the dose ranges from 800 to 2000 mg;
  • The tablets must be swallowed and washed down with warm water, at least 200 ml per dose.

Price varies, depending on the dosage and form of release of the drug. Taking pills into account:

The antibiotic is sold in packs of 10-15 tablets, so by multiplying it is easy to calculate the price for a battery or for the whole pack.

Analogues are cheaper than the drug

It is not worth saving on your health, but sometimes you can get the same effect by paying much less. With a long course of treatment, this matters., and in general, there is no point in overpaying and "donating" money to a pharmaceutical concern.

You can use by other means, by the way, produced in Russia:

  1. Augmentin;
  2. Femoklav;
  3. Amoxicillin;
  4. Ampiox;
  5. Flemoxin.

All listed drugs able to effectively fight infection... Experts prefer to prescribe each of them to choose from at a certain localization of the infectious process itself. Therefore, it is better to stock up on a list of cheaper analogs even before going to the doctor and already in the office to be interested in why exactly they are not suitable for you more cheap drugs... Some health workers have a percentage of the sale of expensive drugs, but in all countries they are trying to fight this practice.

Despite the fact that the transferred funds cost less, they still remain potent antibiotics, the use of which must be approached "wisely". The dosage of each drug is indicated in the instructions, you can consult a pharmacist at the pharmacy's checkout.

Amoxiclav at

During pregnancy, a woman is not protected from any disease, including bacterial infection ... The only problem is that:

  • The body of a pregnant woman is more sensitive to any external stimuli;
  • Anything that affects the mother also affects the child;
  • Even the smallest impact can manifest itself in decades;

  • Most drugs are banned for a period of 9 months;

  • Somehow it is necessary to fight diseases, and not only at the level of traditional medicine.

From the entire list of antibiotics, as a result of long observations, a small number of drugs were isolated that can be used even in such a delicate situation. Among them was amoxiclav, but this does not mean that the tablets can be swallowed for any reason.

Antibiotic still affects the child and can lead to sad consequences, therefore, when prescribing, the doctor asks only one question: What will be more harmful for the mother and the child - an untreated disease or the action of amoxiclav?

Guided by the principle of less harm, the doctor tries to preserve the life and health of the mother, even if it causes serious harm to the baby.

How and when can you drink the drug?

Amoxiclav, like any antibiotic, is prescribed for bacterial infections:

  1. Otitis;
  2. Sinusitis;
  3. Pharyngitis;
  4. Tonsillitis;
  5. Bronchitis;
  6. Pneumonia.

Pathogens can infect genitourinary system, gastrointestinal tract, bone tissue... After examination by an appropriate specialist, the patient will be assigned a full course of therapy, which will also include an antibacterial agent.

Each doctor has his own approach, but amoxiclav is used quite often, it is indicated in the algorithm for the treatment of many bacterial diseases.

You can find a drug at any pharmacy, on quite reasonable price should be used with caution during pregnancy, lactation and childhood. If the immune system cannot cope with a sudden "invasion" on its own, it is necessary to provide it with all possible assistance.

Video instruction about amoxiclav

In this video, the famous doctor Komarovsky will tell you what he thinks about antibiotics and their use, what amoxiclav can help with and how to take it correctly:

Amoxiclav is a popular drug from the antibiotic category. It is often prescribed by physicians and pediatricians for the treatment of chronic infectious diseases. What are the medical features of Amoxiclav, what are its contraindications, and how to use it correctly?

Composition and pharmacological action of Amoxiclav

Amoxiclav consists of two main components. First of all, it is a semi-synthetic penicillin - amoxicillin, as well as clavulanic acid. Each component has its own function. Amoxicillin is an antibiotic, but clavulanic acid does not have a noticeable antibacterial effect. What, then, is its purpose?

As you know, these are one of the first antibiotics obtained in the middle of the last century. During their use, they have shown their high efficiency. But at the same time, many bacteria managed to develop resistance to them. How does bacteria defense against antibacterial drugs work?

Amoxicillin acts on the cell wall of bacteria, binding one of the enzymes that make up it. As a result, the cell wall loses its strength, collapses and the bacteria dies. However, many types of bacteria began to produce special substances - beta-lactamases, which block the action of antibacterial agents. Thus, amoxicillin has become harmless to most bacteria.

Clavulanic acid is designed to fight beta-lactamases. By binding to amoxicillin, it makes its molecules immune to beta-lactamases. This effect is observed in relation to most types of beta-lactamases produced by bacteria.

Thus, the use of a combination of amoxicillin and clavulanic acid makes it possible to expand the spectrum of antibacterial activity in comparison with pure amoxicillin. If amoxicillin can affect only a limited number of bacteria that are not capable of producing beta-lactamases, then amoxicillin, combined with clavulanic acid, is active against most bacteria that cause infectious diseases... Among the bacteria that the drug can destroy, there are both gram-positive and gram-negative bacteria.

The main types of bacteria that are sensitive to Amoxiclav:

  • streptococci,
  • staphylococci,
  • shigella,
  • Klebsiella,
  • brucella,
  • echinococcus,
  • helicobacter,
  • clostridia,
  • Haemophilus influenzae
  • salmonella,
  • Proteus.

Bacteria resistant to the effects of Amoxiclav:

  • enterobacter,
  • pseudomonads,
  • chlamydia,
  • mycoplasma,
  • legionella,
  • Yersinia,

and some others.

Pharmacokinetics

The components of Amoxiclav are well absorbed into the blood and evenly distributed in the main tissues and body fluids, which provides a universal therapeutic effect of the drug. In this case, the components do not penetrate the blood-brain barrier. However, the substances that make up Amoxiclav can penetrate the placental barrier during pregnancy and enter breast milk in small quantities in breastfeeding women. Amoxicillin is poorly metabolized and excreted almost unchanged through the kidneys. In contrast, clavulanic acid is converted to metabolites that are excreted in the urine. The period of elimination of half of the components in healthy kidneys is 1-1.5 hours. The drug can also be removed from the body using hemodialysis.

Average pharmacokinetic parameters

Release form

Amoxiclav is produced mainly in tablet form. There are two types of this form. The main one is a film-coated tablet intended to be swallowed and dissolved in the intestine. There are also quick-dissolving tablets that are sucked in the mouth. You can also purchase the drug in the form of a suspension (powder that requires dilution), and in vials containing a powder, from which you can prepare a solution for intravenous administration.
Amoxiclav tablets can have the following dosage:

  • 250 mg + 125 mg,
  • 500 mg + 125 mg,
  • 875 mg + 125 mg.

The first number indicates the dosage of amixicillin, and the second indicates the dosage of clavulanic acid. The drug is produced by the Slovenian pharmaceutical company Lek.

The powder for the preparation of a solution of Amoxiclav for intravenous administration can contain 500/1000 mg of amoxicillin (100/200 mg of clavulanic acid, respectively). Powder dosage options for the preparation of Amoxiclav suspension are 125, 250 and 400 mg (amoxicillin). The medicine in the form of a suspension is recommended for the treatment of children under 12 years of age, although its use by adults is not excluded. Also available are instant tablets Amoxiclav Kviktab 875 mg + 125 mg.

Indications of the drug Amoxiclav

The scope of application of amoxicillin and clavulanic acid includes the treatment of various infectious diseases caused by bacteria. But most often this combination is prescribed for the treatment of acute respiratory diseases. Amoxiclav reduces the severity of symptoms of the disease and shortens its duration.

For what infections is the drug effective:

  • diseases of the upper and lower respiratory tract, lungs;
  • urological, andrological and gynecological diseases;
  • skin diseases caused by a bacterial infection;
  • connective tissue and bone infections;
  • infectious cholecystitis and cholangitis.

Bacterial diseases respiratory organs, at which the drug can be prescribed:

  • pharyngitis,
  • tonsillitis,
  • laryngitis,
  • rhinitis,
  • sinusitis,
  • sinusitis,
  • pneumonia,
  • pleurisy,
  • bronchitis,
  • tracheitis.

Bacterial infections of the urinary organs and genitals, in which the drug can be used:

  • pyelonephritis,
  • urethritis,
  • prostatitis,
  • adnexitis,
  • endometritis,
  • salpingitis.

Contraindications

The drug has few contraindications. Amoxiclav can be treated with children, including infants. For infants, you can use a suspension and solution for intravenous administration. Pregnant women can also use the drug (under medical supervision). The main contraindication for taking Amoxiclav is intolerance to drugs of the penicillin group, as well as cephalosporins and other betalactam antibacterial agents. Also, you can not take Amoxiclav to persons suffering from severe forms of liver failure, infectious mononucleosis and lymphocytic leukemia, those who previously received amoxicillin led to the development of cholestatic jaundice.

Taking the drug also depends on the condition of the patient's kidneys. People with renal insufficiency (having a creatinine clearance below the norm) should be prescribed smaller doses of Amoxiclav compared to the usual ones.

Dose adjustment for renal failure

Patients on hemodialysis are prescribed a 500 + 125 mg tablet once a day or 2 tablets 250 + 125 mg once a day. In addition, it is taken as a 500 + 125 tablet or 2 tablets of 250 + 125 mg mg during dialysis.

Children under 12 years of age are not prescribed tablet forms of Amoxiclav. For them, it is preferable to use a suspension.

The use of Amoxiclav during pregnancy and breastfeeding

Amoxiclav is prescribed with caution during pregnancy. Its use is possible in cases where the potential benefit to the mother is higher than the harm that can be done to the developing fetus. During lactation, the drug can also be used. However, if it becomes necessary to use Amoxiclav while breastfeeding, it is recommended that you first consult with your doctor.

Side effects of Amoxiclav

The drug is well-tolerated, and side effects when taking Amoxiclav appear infrequently. The most common side effects are those related to the gastrointestinal tract. Like any antibiotic, Amoxiclav destroys not only pathogens, but also the normal intestinal microflora. Therefore, with a long course of treatment with Amoxiclav, phenomena associated with dysbiosis are possible - dyspepsia, nausea, abdominal pain.

On the skin, mucous membranes and in the oral cavity, candidiasis can develop - a lesion by fungi of the genus Candida. Side effects associated with dysbiosis are the most common when taking Amoxiclav. Also, while taking Amoxiclav, many women may experience candidal colpitis (thrush).
Another group of side effects of Amoxiclav is allergic reactions. They can manifest themselves, for example, in the form of a skin rash, hives, dermatitis. In such a case, it is recommended to stop taking the drug and consult a doctor. It is extremely rare, due to the intake of Amoxiclav, anaphylactic shock may appear.

When using Amoxiclav, side effects associated with impaired liver function may also appear - cholestatic jaundice and hepatitis. These phenomena were most often observed in the elderly and men, especially with a long course of treatment.

There may be others as well. side effects: headaches, dizziness, insomnia, changes in blood composition (leukopenia, neutropenia, thrombocytopenia, agranulocytosis), anemia, changes in urine (crystalluria, blood), pseudomembranous colitis.

Overdose with Amoxiclav

In clinical practice, no fatal overdose cases are known. When taking the drug in doses significantly higher than those prescribed by the instructions, you may experience:

  • abdominal pain,
  • diarrhea,
  • vomit,
  • excitation,
  • anxiety,
  • insomnia,
  • dizziness.

Treatment for an overdose of Amoxiclav is symptomatic, the intake of activated carbon, gastric lavage is indicated.

Instructions for use

The dosage of Amoxiclav may depend on many factors - the type of disease, its severity, the patient's age, the functionality of his kidneys, etc. Therefore, the exact dose should be prescribed by an infectious disease doctor or therapist. Too low a dose of Amoxiclav can lead to the fact that bacteria will be immune to it and will be able to develop resistance, and too high entails the risk of side effects.

For infections occurring with low intensity, one tablet of Amoxiclav 250 + 125 mg three times a day is usually prescribed, or a tablet of 500 + 125 twice a day. In severe diseases, 3 tablets of Amoxiclav 500 + 125 mg per day or 2 tablets of 875 + 125 mg per day can be prescribed.

In case of odontogenic infections, it is usually prescribed a 250 + 125 mg tablet every 8 hours or a 500 + 125 mg tablet every 12 hours. The course of treatment is 5 days.

Children are prescribed a dose based on their weight. It should be remembered that for children it is preferable to use a suspension rather than tablets. For infections occurring in mild and medium form, it is recommended to use a dose of 20 mg / kg body weight; in severe infections, it should be doubled. Amoxiclav packaging is equipped with special instructions that allow you to calculate the dose for children in various cases.

The suspension powder is available in three versions.

Doses of active substances per 5 ml of powder for suspension

Doses of suspension 125 + 31.25 mg for children

Suspension doses 250 + 62.5 mg for children

The volume of the drug indicated in the tables must be given to the child 3 times a day.

Doses of suspension 400 mg + 57 mg for children

The amount of the drug indicated in the table must be given to the child 2 times a day.

When choosing the right dose, it is necessary to proceed from the child's body weight, not age.

In case of insufficient renal function, the dose should be adjusted. With a reduced creatinine clearance (10-30 ml / min), the maximum dose of Amoxiclav is one tablet of 500 + 125 mg twice a day after 12 hours, with a clearance of less than 10 ml - this tablet can be taken no more than once every 24 hours.

The medicine should be taken at strictly defined intervals. Thus, if three tablets are prescribed per day, they should be taken exactly 8 hours later, for example, at 8, 16 and 24 hours. If the drug is prescribed twice a day, then the tablets should be taken after 12 hours. This method allows you to maintain a constant concentration of the drug in the blood, as a result of which the effectiveness of Amoxiclav will be maximum.

The absorption of active substances into the blood occurs regardless of food intake, therefore, Amoxiclav can be taken before, after, and during a meal, this will not reduce its effectiveness. However, doctors still recommend taking the tablets at the beginning of a meal. This will reduce the likelihood of unpleasant side effects associated with the gastrointestinal tract.

Patients over 12 years old and weighing more than 40 kg take an adult dose of suspension or tablets. Dose adjustment is necessary for persons with renal dysfunction associated with a decrease in creatinine clearance.

The duration of treatment is 5-14 days. Exceeding this period requires special instructions from the attending physician. In case of ineffectiveness of drug treatment, you should choose a replacement. If the drug was prescribed, and the condition improved before the course was completed, then it should still be completed in order to avoid relapses.

When using Amoxiclav Kviktab, the tablet must be dissolved in water before use, or dissolve in the mouth.

Suspension preparation

To prepare the suspension, shake the vial with the powder vigorously and then add water to it to the mark in two steps. Each time you add water, you must shake the bottle in order for the suspension to have a uniform consistency.

Required volume of water for preparation of suspension from powder 400 / 57.5 mg

Drug analogs

The complete structural analogs of Amoxiclav include preparations containing amoxicillin and clavulanic acid, for example, Augmentin, Flemoklav Solutab. Preparations containing only amoxicillin will not be an adequate substitute due to the fact that the list of microorganisms sensitive to pure amoxicillin is much smaller than that of Amoxiclav. The same can be said about other drugs of the penicillin group - the scope of their use may not coincide with the scope of application of Amoxiclav.

Interaction of Amoxiclav with other substances and drugs

The effectiveness of Amoxiclav usually increases with simultaneous use with other bactericidal drugs. However, macrolides, tetracyclines, sulfonamides and other bacteriostatic agents reduce the effectiveness of the drug. Therefore, it is necessary to avoid the simultaneous administration of the drug and bacteriostatic agents. It should also be remembered that the simultaneous administration of Amoxiclav with hormonal contraceptives weakens the effect of the latter.

The simultaneous intake of alcohol and Amoxiclav is prohibited, since this may have a negative effect on the liver and a decrease in the effect of the drug.

The simultaneous administration of Amoxiclav and methotrexate is also prohibited, since Amoxiclav increases the toxicity of the latter. You can not prescribe the drug at the same time as Disulfiram, as this increases the likelihood of allergic reactions. When taken simultaneously with Allopurinol, the risk of developing exanthema increases.

Caution should be exercised when taking a suspension or tablets in combination with oral anticoagulants, as the drug can increase the prothrombin time.

Amoxiclav
Buy Amoxiclav in pharmacies

DOSAGE FORMS
coated tablets 875mg / 125mg
film-coated tablets 875mg + 125mg

MANUFACTURERS
Lek dd (Slovenia)

GROUP
Combined antimicrobial agents

COMPOUND
Active ingredients: 875 mg of amoxicillin in the form of trihydrate and 125 mg of clavulanic acid in the form of potassium salt.

INTERNATIONAL NON-PATENTED NAME
Amoxicillin + Clavulanic Acid

SYNONYMS
Amoxiclav Kviktab, Arlet, Augmentin, Augmentin EC, Augmentin SR, Klamosar, Medoklav, Panklav, Ranklav, Rapiklav, Sinulox, Sinulox RTU, Flemoklav Solutab, Ekoklav

PHARMACHOLOGIC EFFECT
The drug is a combination of amoxicillin and clavulanic acid. Amoxicillin is a semi-synthetic penicillin (beta-lactam antibiotic) that inhibits one or more enzymes (often referred to as penicillin-binding proteins, PBPs) in the biosynthetic pathway of peptidoglycan, which is an integral structural component of the bacterial cell wall. Inhibition of peptidoglycan synthesis leads to a loss of cell wall strength, which usually leads to lysis and death of microbial cells. Amoxicillin is destroyed by the action of beta-lactamases produced by resistant bacteria, thus, the spectrum of activity of amoxicillin alone does not include microorganisms that produce these enzymes. Clavulanic acid is a beta-lactam structurally related to penicillins. It inhibits some beta-lactamases, thereby preventing the inactivation of amoxicillin and expands its spectrum of activity, including bacteria that are usually resistant to amoxicillin, as well as to other penicillins and cephalosporins. By itself, clavulanic acid has no clinically significant antibacterial effect. The drug has a bactericidal effect in vivo on the following microorganisms: Gram-positive aerobes. Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes. Gram-negative aerobes. Enterobacter spp, Escherichia coli, Haemophilus influenza, Species of the genus Klebsiella, Moraxella catarrhalis (Branhamella catarrhalis). The drug has an in vitro bactericidal effect on the following microorganisms (however, clinical dependence is still unknown). Gram-positive aerobes. BacilHs anthracis. Species of the genus Corynebacterium, Enterococcus faecalis, Enterococcus faecium, Listeria monocytogenes, Nocardia asteroids, Coagulase-negative staphylococci (including Staphylococcus epidermidis) Streptococcus agalaciiae. Other species of the genus Streptococcus Streptococcus viridians. Gram-positive anaerobes. Species of the genus Clostridium, Species of the genus Peptococcus, Species of the genus Peptostreptococcus. Gram-negative aerobes. Bordetella pertussis, Species of the genus Brucella, Gardnerella vaginalis, Helicobacter pylori, Species of the genus Legionella, Neisseria gonorrhoeae, Neisseria meningitides, Pasteurella multocida, Proteus mirabilis, Proteus vulgaris, Species of the genus Salmonella, Species of the genus Shigleella, Vibriera Yersinia enterocolitica... Gram-negative anaerobes. Species of the genus Bacteroides (including Bacteroides fragilis), Species of the genus Fusobacterium. Others: Borrella burgdorferi, Chlamydia spp., Leptospira icterohaemorrhagiae, Treponema pallidum. Some strains of these bacterial species produce beta-lactamases, which contribute to their insensitivity to monotherapy with amoxicillin. Pharmacokinetics. The main pharmacokinetic parameters of amoxicillin and clavulanic acid are similar. Amoxicillin and clavulanic acid dissolve well in aqueous solutions with a physiological pH value and after taking the drug inside, they are quickly and completely absorbed from the gastrointestinal tract (GIT). The absorption of the active substances of amoxicillin and clavulanic acid is optimal if taken at the beginning of a meal. The bioavailability of amoxicillin and clavulanic acid after oral administration is about 70%. Peak plasma concentrations are reached approximately 1 hour after ingestion. The maximum concentration values ​​for amoxicillin (depending on the dose) are 3-12 μg / ml, for clavulanic acid - about 2 μg / ml. With the use of the drug, the plasma concentrations of amoxicillin / clavulanic acid are similar to those with oral administration of the corresponding doses of amoxicillin or clavulanic acid separately in equivalent doses. Both components are characterized by a good volume of distribution in various bodies, tissues and fluids of the body (including in the lungs, organs abdominal cavity; adipose, bone and muscle tissues; pleural, synovial and peritoneal fluids; in the skin, bile, urine, purulent discharge, sputum, in the interstitial fluid). Plasma protein binding is moderate: 25% for clavulanic acid and 18% for amoxicillin. The volume of distribution is approximately 0.3-0.4 l / kg for amoxicillin and approximately 0.2 l / kg for clavulanic acid. Amoxicillin and clavulanic acid do not cross the blood-brain barrier in non-inflamed meninges... Amoxicillin (like most penicillins) is excreted in breast milk. V breast milk also found trace amounts of clavulanic acid. Amoxicillin and clavulanic acid cross the placental barrier. Amoxicillin is excreted primarily by the kidneys, while clavulanic acid is eliminated by both renal and extrarenal mechanisms. After a single oral administration of one tablet of 250 mg / 125 mg or 500 mg / 125 mg, approximately 60-70% of amoxicillin and 40-65% of clavulanic acid are excreted unchanged in the urine during the first 6 hours. About 10-25% of the initial dose of amoxicillin is excreted in the urine as inactive penicillic acid. Clavulanic acid in the human body undergoes intensive metabolism with the formation of 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid and 1-amino-4-hydroxy-butan-2-one and is excreted in urine and feces. The average elimination half-life of amoxicillin / clavulanic acid is approximately one hour, the average total clearance is approximately 25 l / h in healthy patients. In the course of various studies, it was found that the excretion of amoxicillin in the urine within 24 hours is approximately 50-85%, clavulanic acid - 27-60%. The largest number clavulanic acid is excreted within the first 2 hours after ingestion. Patients with impaired liver function. In patients with severe renal insufficiency, the half-life is increased to 7.5 hours for amoxicillin and up to 4.5 hours for clavulanic acid. For patients with impaired liver function, the dose of the drug should be selected with caution, it is necessary to constantly monitor the state of the liver. Both components are removed by hemodialysis and minor amounts by peritoneal dialysis.

INDICATIONS FOR USE
Infections caused by sensitive strains of microorganisms: infections of the upper respiratory tract and ENT organs (including acute and chronic sinusitis, acute and chronic otitis media, retropharyngeal abscess, tonsillitis, pharyngitis); lower respiratory tract infections (including acute bronchitis with bacterial superinfection, Chronical bronchitis, pneumonia); urinary tract infections; infections in gynecology; infections of the skin and soft tissues, as well as wounds from human and animal bites; bone and connective tissue infections; infections biliary tract(cholecystitis, cholangitis); odontogenic infections.

CONTRAINDICATIONS
Hypersensitivity to the components of the drug; a history of hypersensitivity to penicillins, cephalosporins and other beta-lactam antibiotics, cholestatic jaundice and / or other liver dysfunctions caused by a history of amoxicillin / clavulanic acid; infectious mononucleosis and lymphocytic leukemia.

SIDE EFFECT
From the digestive system: loss of appetite, nausea, vomiting, diarrhea, abdominal pain, gastritis, stomatitis, glossitis, black "hairy" tongue, darkening of tooth enamel, hemorrhagic colitis (can also develop after therapy), enterocolitis, pseudomembranous colitis, violation liver function, increased activity of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and / or the level of bilirubin in the blood plasma, liver failure (more often in the elderly, men, with prolonged therapy), cholestatic jaundice, hepatitis. Allergic reactions: itching, urticaria, erythematous rash, multiforme exudative erythema, angioedema, anaphylactic shock, allergic vasculitis, exfoliative dermatitis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, a syndrome similar to serum sickness, toxic epidermal necrolysis. From the hematopoietic system and lymphatic system: reversible leukopenia "(including neutropenia), thrombocyte singing, hemolytic anemia, reversible increase in prothrombin in time (when used together with anticoagulants), reversible increase in bleeding time, eosinophilia, pancytopenia, thrombocytosis, agranulocytosis. From the central nervous system: dizziness, headache, convulsions (can occur in patients with impaired renal function when taking high doses of the drug), hyperactivity. Anxiety, insomnia, change in behavior, agitation. From the urinary system: interstitial nephritis, crystalluria, hematuria. Other: candidiasis and other types superinfection.

INTERACTION
Antacids, glucosamine, laxatives, aminoglycosides slow absorption, ascorbic acid increases absorption. Diuretics, allopurinol, phenylbutazone; nonsteroidal anti-inflammatory drugs and other drugs that block tubular secretion (probenecid) increase the concentration of amoxicillin (clavulanic acid is excreted mainly by glomerular filtration). The simultaneous use of the drug and methotrexate increases the toxicity of methotrexate. Prescribing in conjunction with allopurinol increases the incidence of exanthema. Simultaneous use with disulfiram should be avoided. Reduces the effectiveness of drugs, in the process of metabolism of which para-aminobenzoic acid is formed, ethinylestradiol - the risk of bleeding "breakthrough". The literature describes rare cases of an increase in the international normalized ratio (MHO) in patients with the combined use of acenocoumarol or warfarin and amoxicillin. If it is necessary to use it simultaneously with anti-coagulants and protobin time or MHO, it should be carefully iterated when prescribing or discontinuing the drug. The combination with rifampicin is antagonistic (mutual weakening of the antibacterial effect). The drug should not be used simultaneously in combination with bacteriostatic antibiotics (macrolides, tetracyclines), sulfonamides due to a possible decrease in the effectiveness of the drug. The drug reduces the effectiveness of oral contraceptives.

DOSAGE AND METHOD OF APPLICATION
Inside. The dosage regimen is set individually, depending on the age, body weight, kidney function of the patient, as well as the severity of the infection. It is recommended to take the drug at the beginning of a meal for optimal absorption and to reduce possible side effects from the digestive system. The course of treatment is 5-14 days. The duration of the course of treatment is determined by the attending physician. The course should not continue for more than 14 days without a second medical examination. Children under 12 years old. The dose is prescribed depending on the age and body weight. Recommended dosage regimen: 40 mg / kg / day in 3 divided doses. Children weighing 40 kg or more should be given the same doses as adults. For children under 6 years of age, it is more preferable to take a suspension of the drug. Adults and children over 12 years old (or more than 40 kg of body weight). The usual dose for mild to moderate infections is 1 tablet every 12 hours, for severe infections and respiratory tract infections, 1 tablet every 8 hours. Since tablets of a combination of amoxicillin and clavulanic acid of 250 mg + 125 mg and 500 mg-125 mg contain the same amount of clavulanic acid -125 mg, 2 tablets of 250 mg + 125 mg are not equivalent to 1 tablet of 500 mg + 125 mg. Dosage for odontogenic infections: 1 tablet every 12 hours for 5 days. Patients with impaired renal function. Dose adjustments are based on the maximum recommended dose of amoxicillin and are based on creatinine clearance (CC) values. Adults and children over 12 years old (or more than 40 kg of body weight). CC> 30 ml / min: dose adjustment is not required. In case of anuria, the interval between dosing should be increased to 48 hours or more. Tablets 875 mg + 125 mg should be used only in patients with CC> 30 ml / min. Patients with impaired liver function. The drug should be taken with caution. It is necessary to carry out regular monitoring of liver function.

OVERDOSE
There are no reports of death or life-threatening side effects due to drug overdose. In most cases, overdose symptoms include gastrointestinal disorders (abdominal pain, diarrhea, vomiting). Anxiety, insomnia, dizziness, and in isolated cases - convulsive seizures are also possible. In case of an overdose, the patient should be under medical supervision, treatment is symptomatic. In the case of a recent intake (less than 4 hours), it is necessary to perform a gastric lavage and prescribe Activated carbon to reduce absorption. Amoxicillin / clavulanic acid is removed by hemodialysis.

SPECIAL INSTRUCTIONS
Carefully. History of pseudomembranous colitis, diseases of the gastrointestinal tract, liver failure, severe renal dysfunction, pregnancy, lactation, with simultaneous use with anticoagulants. Application during pregnancy and during the period breastfeeding... During pregnancy and lactation, the drug is used only if the intended benefit to the mother outweighs the potential risk to the fetus and child. During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver, and kidneys. In patients with severely impaired renal function, an adequate dose adjustment or an increase in the intervals between doses is required. In order to reduce the risk of side effects from the gastrointestinal tract, the drug should be taken with meals. The development of superinfection is possible due to the growth of microflora insensitive to it, which requires a corresponding change antibacterial therapy... In patients with increased sensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible. In women with premature rupture of the membranes, it was found that preventive therapy amoxicillin + clavulanic acid may be associated with an increased risk of necrotizing colitis in newborns. Crystalluria is very rare in patients with reduced urine output. During the use of large doses of amoxicillin, it is recommended to take a sufficient amount of fluid and maintain adequate diuresis to reduce the likelihood of amoxicillin crystals forming. Laboratory tests: high concentrations of amoxicillin give a false positive reaction to urine glucose when using Benedict's reagent or Fehling's solution. It is recommended to use enzymatic reactions with glucosidase. Special precautions for the destruction of unused medicinal product. There is no need for special precautions when disposing of an unused product. Impact on the ability to manage vehicles and engaging in other activities that require concentration of attention and speed of psychomotor reactions. Due to the possibility of developing side effects from the central nervous system, such as dizziness, headache, convulsions, during treatment, care should be taken when driving and engaging in other activities that require concentration of attention and speed of psychomotor reactions.

STORAGE CONDITIONS
Store in a dry place out of the reach of children at a temperature not exceeding 25 C.

Part tablets 250 mg / 125 mg includes active components amoxicillin (trihydrate form) and clavulanic acid (a form of potassium salt). The tablets also contain auxiliary components: MCC sodium croscarmellose.

Amoxiclav tablets 2X 625 mg and 1000 mg contain the active ingredients amoxicillin and clavulanic acid, as well as additional components: anhydrous colloidal silicon dioxide, flavorings, , yellow iron oxide, talc, hydrogenated castor oil, silicified MCC.

As part of tablets Amoxiclav Kviktab 500 mg and 875 mg contains active ingredients amoxicillin and clavulanic acid, as well as additional components: anhydrous colloidal silicon dioxide, flavorings, aspartame, yellow iron oxide, talc, hydrogenated castor oil, silicified MCC.

As part of powder from which the Amoxiclav suspension is prepared, also contains amoxicillin and clavulanic acid, as well as sodium citrate, MCC, sodium benzoate, mannitol, sodium saccharin as inactive components.

As part of powder for preparation of infusion Amoxiclav IV contains amoxicillin and clavulanic acid.

Release form

The drug is produced in tablet form. Amoxiclav 250 mg / 125 mg- coated tablets, the package contains 15 pcs.

Amoxiclav 2X(500 mg / 125 mg; 875 mg / 125 mg) - coated tablets, the package may contain 10 or 14 pieces.

Amoxiclav Kviktab(500 mg / 125 mg; 875 mg / 125 mg) is available in the form of dispersed tablets, in a package - 10 such tablets.

Also, the product is produced in the form of a powder, from which a suspension is made; the vial contains a powder for preparing 100 ml of the product.

A powder is also produced, from which a solution is made, which is administered intravenously. The vial contains 600 mg of the agent (amoxicillin 500 mg, clavulanic acid 100 mg), vials of 1.2 g are also available (amoxicillin 1000 mg, clavulanic acid 200 mg), the package contains 5 fl.

pharmachologic effect

The abstract provides information that Amoxiclav (INN Amoksiklav) is a means of a wide range of effects. Antibiotic group: penicillins with a wide range of effects. The drug contains amoxicillin (semi-synthetic penicillin) and clavulanic acid (β-lactamase inhibitor). The presence of clavulanic acid in the preparation ensures the resistance of amoxicillin to the action of β-lactamases, which are produced by microorganisms.

The structure of clavulanic acid is similar to beta-lactam antibiotics, this substance also has an antibacterial effect. Amoxiclav is active against strains that show sensitivity to amoxicillin. This is a row gram-positive bacteria , aerobic gram-negative bacteria , gram-positive and gram-negative anaerobes .

Pharmacokinetics and pharmacodynamics

As the Vidal drug guide informs, after oral administration, both substances are actively absorbed from the gastrointestinal tract, the absorption of the components is not affected by food intake, therefore it does not matter how to take it - before or after meals. The highest concentration is observed one hour after the drug was taken. Both active ingredients of the drug are distributed in fluids and tissues. Amoxicillin also enters the liver, synovial fluid, prostate, tonsils, gallbladder, muscle tissue, saliva, bronchial secretions.

If the membranes of the brain are not inflamed, both active substances do not penetrate through the BBB. At the same time, active components penetrate the placental barrier, their traces are determined in breast milk. They bind to blood proteins to an insignificant extent.

In the body, amoxicillin undergoes partial, clavulanic acid is metabolized intensively. It is excreted from the body through the kidneys, small particles of active substances are excreted by the intestines and lungs. The half-life of amoxicillin and clavulanic acid is 1-1.5 hours.

Indications for the use of Amoxiclav

Amoxiclav is prescribed for diseases of an infectious and inflammatory nature that develop as a result of the influence of microorganisms sensitive to this drug. The following indications for the use of this drug are determined:

  • infections of ENT organs, as well as infectious diseases of the upper respiratory tract ( , retropharyngeal abscess, , , tonsillitis);
  • urinary tract infections (with , at and etc.);
  • infectious diseases of the lower respiratory tract (pneumonia, acute and chronic);
  • gynecological diseases of an infectious nature;
  • infections of connective and bone tissues;
  • infectious diseases of soft tissues, skin (including the consequences of bites);
  • biliary tract infections (cholangitis, );
  • odontogenic infections.

What else helps Amoxiclav, you should ask a specialist for an individual consultation.

Contraindications

When determining why tablets and other forms of the drug help, you should also take into account the existing contraindications:

  • previous liver disease or cholestatic jaundice while taking clavulanic acid or amoxicillin;
  • high sensitivity to antibiotic drugs from the group of cephalosporins, penicillins, as well as other beta-lactam antibiotics;
  • high sensitivity to the active ingredients of the drug.

Cautiously assigned to people suffering from liver failure, people with severe kidney disease.

Side effects

When taking this antibiotic, patients may experience the following side effects:

  • Digestive system: aggravation, vomiting, nausea, ; in rare cases, there may be abdominal pain, liver dysfunction; isolated manifestations - hepatitis, jaundice, pseudomembranous colitis.
  • Hematopoietic system: in rare cases - reversible leukopenia, thrombocytopenia; in very rare cases - eosinophilia, pancytopenia.
  • Allergic manifestations:, erythematous rash, ; in rare cases - , exudative erythema, allergic vasculitis; isolated manifestations - Stevens-Johnson syndrome, pustulosis, exfoliative dermatitis.
  • Nervous system functions:,; in rare cases - convulsions, anxiety, hyperactivity, .
  • urinary system: crystalluria , interstitial nephritis .
  • In rare cases, there may be a manifestation of superinfection.

It is noted that such treatment, as a rule, does not provoke pronounced side effects.

Instructions for use of Amoxiclav (Method and dosage of Amoxiclav for adults)

The medicine in tablets is not prescribed for children under 12 years of age. When prescribing the drug, it should be borne in mind that the permissible daily dose of clavulanic acid is 600 mg (for adults) and 10 mg per 1 kg of weight (for a child). The permissible daily dose of amoxicillin is 6 g for an adult and 45 mg per 1 kg of weight for a child.

Means for parenteral administration are prepared by dissolving the contents of the vial in water for injection. To dissolve 600 mg of the product, you need 10 mol of water, to dissolve 1.2 g of the product - 20 ml of water. The solution should be injected slowly over 3-4 minutes. Intravenous infusion should be continued for 30-40 minutes. You cannot freeze the solution.

Before anesthesia, for the prevention of purulent complications, it is necessary to inject 1.2 g of drugs intravenously. If there is a risk of complications, the drug is administered intravenously or administered orally after surgery. The duration of the appointment is determined by the doctor.

Amoxiclav tablets, instructions for use

As a rule, adults and children (whose weight is more than 40 kg) receive 1 table every eight hours. (375 mg), provided the infection is mild or moderate... Another acceptable treatment regimen in this case is taking 1 table every 12 hours. (500 mg + 125 mg). In severe infectious diseases, as well as in infectious diseases of the respiratory tract, 1 table is indicated every eight hours. (500 mg + 125 mg) or taking 1 table every 12 hours. (875 mg + 125 mg). Depending on the disease, you need to take an antibiotic from five to fourteen days, but the doctor must individually prescribe a therapy regimen.

Patients with odontogenic infections are shown taking the medication every 8 hours, 1 table. (250 mg + 125 mg) or once 12 hours for 1 table. (500 mg + 125 mg) for five days.

People suffering from moderate are shown taking 1 table. (500 mg + 125 mg) every twelve hours. Severe renal failure is the reason for increasing the interval between doses up to 24 hours.

Suspension Amoxiclav, instructions for use

The child's age of the patient provides for the calculation of the dose taking into account the weight of the child. Shake the bottle well before preparing the syrup. In two steps, you need to add 86 ml of water to the bottle, each time you need to shake well its contents. It should be noted that the measuring spoon contains 5 ml of the product. Prescribed in a dose depending on the age and weight of the child.

Instructions for the use of Amoxiclav for children

Children from birth to three months are prescribed the drug at the rate of 30 mg per 1 kg of body weight (dose per day), this dose must be divided equally and administered at regular intervals. From the age of three months of the child, Amoxiclav is prescribed in a dose of 25 mg per 1 kg of weight, it is similarly divided equally into two injections. For infectious diseases of moderate severity, the dose is prescribed at the rate of 20 mg per 1 kg of body weight, it is divided into three injections. In severe infectious diseases, the dose is prescribed at the rate of 45 mg per 1 kg of body weight, divided into two doses per day.

Instructions for use Amoxiclav Kviktab

Before taking the tablet, dissolve in 100 ml of water (the amount of water may be higher). Stir the contents well before taking. You can also chew a pill, it is better to use the drug before meals. Adults and children after reaching 12 years of age should take 1 table per day. 625 mg 2-3 times a day. For severe infectious diseases, 1 table is prescribed. 1000 mg 2 times a day. Treatment should not last more than 2 weeks.

Sometimes the doctor can prescribe analogues of the drug, for example, Flemoklav Solutab and others.

Amoxiclav for angina

The drug Amoxiclav at an adult is prescribed 1 table. 325 mg once every 8 hours. Another treatment regimen involves taking 1 tablet once every 12 hours. A doctor may prescribe a higher dose of an antibiotic if the adult's illness is severe. Treatment of angina in children involves the use of a suspension. As a rule, 1 spoon is prescribed (a dosage spoon is 5 ml). The frequency of admission is determined by the doctor, whose recommendations it is important to follow. How to take Amoxiclav for children with angina depends on the severity of the disease.

Dosage of Amoxiclav for sinusitis

Does Amoxiclav help with , depends on the causes and characteristics of the course of the disease. The dosage is determined by the otolaryngologist. It is recommended to take 500 mg tablets three times a day. How many days to take the medicine depends on the severity of the disease. But after the symptoms disappear, you need to take the remedy for another two days.

Overdose

To avoid overdose, the prescribed dosage for children and the dosage of Amoxiclav for adults should be strictly observed. It is recommended to carefully study the instructions or watch a video on how to dilute the suspension.

Wikipedia testifies that with an overdose of the drug, a number of unpleasant symptoms may appear, but there is no data on the life-threatening conditions of the patient. Overdose may cause stomach pain , vomiting , excitement. In severe cases, convulsions may occur.

If the drug has been recently taken, gastric lavage is indicated, ... The patient should be supervised by a doctor. In this case, effective .

Interaction

With the simultaneous administration of the drug with some drugs, undesirable manifestations may occur, which is why tablets, syrup and intravenous administration of the drug should not be used in parallel with a number of drugs.

Simultaneous use of drugs with , antacids, aminoglycosides, laxatives, the absorption of Amoxiclav slows down, when taken simultaneously with - the absorption is accelerated.

With simultaneous treatment with Phenylbutazone, diuretics, NSAIDs, Allopurinol and other drugs that block tubular secretion, an increase in the concentration of amoxicillin occurs.

If anticoagulants and Amoxiclav are taken simultaneously, the prothrombin time increases. Therefore, it is necessary to prescribe funds in such a combination with caution.

Amoxiclav increases toxicity while taking.

When taking Amoxiclav and the likelihood of exanthema manifestation increases.

Should not be taken at the same time Disulfiram and Amoxiclav.

Antagonists when taken together are amoxicillin and ... The drugs mutually weaken the antibacterial effect.

You should not take Amoxiclav and bacteriostatic antibiotics (tetracyclines, macrolides), as well as sulfonamides at the same time, as these drugs can reduce the effectiveness of Amoxiclav.

If a course of drug treatment is prescribed for adults or children, it is important to monitor the functions of the kidneys, liver, and the process of hematopoiesis.

People who have impaired renal function need a dose adjustment of the medication or an increase in the interval between taking drugs.

It is optimal to take the product with meals to reduce the likelihood of side effects from the digestive system.

Patients undergoing treatment with Amoxiclav may experience false positive reaction in the process of determining glucose in urine when using Felling's solution or Benedict's reagent.

There is no data on the negative impact of Amoxiclav on the ability to drive vehicles and work with precision mechanisms.

Patients who are interested in whether Amoxiclav is an antibiotic or not, it should be borne in mind that the agent is an antibacterial drug.

If Amoxiclav is prescribed, childhood the patient must be taken into account when prescribing the form of the drug and dosage.

Analogs of Amoxiclav

Matching ATX level 4 code:

There are a number of analogues of this drug. The price of analogs depends, first of all, on the manufacturer of the drug. On sale there are analogs cheaper than Amoxiclav. For patients who are interested in how this antibiotic can be replaced, experts offer a large list of drugs. This means Moxiclav , Ko-Amoxiclav , , Clavocin , Flemoklav , Medoclav , Bactoclav , Ranclave , Amovikomb and others. However, only a doctor should prescribe any substitute. You can pick up more cheap analog in tablets, for example, Augmentin. You can also pick up Russian counterpart eg Amoxicillin.

Flemoklav Solutab and Amoxiclav: the difference between drugs

The active components of the drugs are similar. The difference between drugs is in the dosage of active ingredients in the release forms of these drugs. Both drugs are in roughly the same price range.

Which is better: Amoxiclav or Augmentin?

What is the composition of the funds Amoxiclav and Augmentin, what is the difference between these drugs? Both of these funds contain similar active ingredients, that is, in fact, they are one and the same. Respectively, pharmachologic effect drugs are almost identical, as are the side effects. Only the manufacturers of these drugs differ.

Which is better: Sumamed or Amoxiclav?

Sumamed contains azithromycin in its composition, it is an antibiotic with a wide range of effects. Before prescribing any of the drugs, it is important to check the sensitivity of the microflora to their action.

Which is better: Flemoxin Solutab or Amoxiclav?

As part of the product contains only amoxicillin. Accordingly, its spectrum of influence is less than that of the drug Amoxiclav, which also contains clavulonic acid .

Amoxiclav for children

Children should only take antibiotics after a doctor's prescription. It is important to adhere to the indicated dosage. Children under 12 years of age are usually prescribed a suspension. The dosage of the Amoxiclav suspension for children depends on the severity of the disease and the diagnosis. As a rule, children under 2 years of age are prescribed a dose of 62.5 mg, at the age of 2 to 7 years - 125 mg, at the age of 7 to 12 years - 250 mg.

Amoxiclav and alcohol

Do not combine this drug with alcohol. When taken simultaneously, the load on the liver increases significantly, and the likelihood of a number of negative effects also increases.

Amoxiclav during pregnancy and lactation

Amoxiclav can be used if the expected effect exceeds possible harm for the fetus. It is undesirable to use the drug Amoxiclav for early dates pregnancy. The 2nd trimester and the 3rd trimester are more preferable, but even during this period, the dosage of Amoxiclav during pregnancy should be observed very accurately. Amoxiclav is not prescribed, since the active components of the drug penetrate into breast milk.

Amoxiclav 500/125 belongs to the group of penicillin antibacterial agents used to combat many diseases caused by infections of a bacterial nature. It is a complex medication consisting of two components with antibacterial activity.

Amoxiclav is a product of an Austrian pharmaceutical company.

The medication is available in the following forms:

  • in tablets with a dosage of 250 mg / 125 mg with a thin intestinal-soluble coating;
  • in tablets with a dosage of 500 mg / 125 mg with an enteric coating;
  • in the form of tablets for resorption, dissolution in water - Amoxiclav Kviktab with a dosage of 500 mg / 125 mg;
  • in the form of a powder, which makes it possible to prepare a suspension for children;
  • in powder form, for the preparation of intravenous injections.

The tablet form of Amoxiclav includes the following components that actively act on the body:

  • amoxicillin 500 mg;
  • clavulanic acid 125 mg.

The tablets, in addition to active substances, consist of the following auxiliary components, which do not have a therapeutic effect:

  • cellulose;
  • silicon dioxide;
  • polysorbate;
  • titanium dioxide;
  • magnesium stearate.

Amoxiclav Kviktab tablets, in addition to active ingredients, consist of the following auxiliary ingredients:

  • aspartame;
  • silicon dioxide;
  • iron oxide;
  • castor oil;
  • flavors.

The suspension, along with the active ingredients, includes in its composition substances that do not have a therapeutic effect on bacteria:

  • mannitol;
  • sodium citrate;
  • sodium saccharin;
  • sodium benzoate.

For your information. The injection powder contains only active ingredients.

Pharmacological action, pharmacodynamics and pharmacokinetics


Instructions for use indicate the presence of the following pharmacological activity of Amoxiclav:

  • a penicillin-derived drug has a bactericidal effect, disrupts cell synthesis. Thus, destroying pathogenic microorganisms;
  • clavulanic acid enhances the effectiveness of amoxicillin. The second active component of Amoxiclav also has an antimicrobial effect;
  • the drug is active against gram-positive anaerobes;
  • the drug is effectively taken with gram-negative anaerobes.

Amoxiclav quickly acts on pathogenic microorganisms. Already 60 minutes after taking it, the highest concentration of the active ingredients in the plasma is determined. The active ingredient of the antibiotic is absorbed into circulatory system from the intestines, from where it spreads throughout the body. Medicine excreted through the urinary system within an hour.

In what cases is Amoxiclav prescribed

The indications for prescribing a medication are:

  • infectious ENT diseases;
  • urinary infections;
  • pathologies of the bronchi, lungs caused by infections;
  • bacterial processes of the upper respiratory tract;
  • gynecological infections, postpartum inflammation;
  • infectious processes of connective tissues;
  • bone diseases;
  • skin infectious diseases, post-burn conditions;
  • inflammatory processes of bones, joints;
  • infected processes of the abdominal cavity;
  • odotogenic infections;
  • infection of teeth, jaw;
  • preoperative, postoperative period.

Important! Amoxiclav is taken only to eliminate an infection that marks sensitivity to the penicillin series.

Instructions for use and dosage

It is recommended to drink a penicillin-containing drug after consulting a doctor. It is important to find out whether bacteria are susceptible to antibiotics by conducting bacteriological studies. Recommendations for dosage, frequency of administration, duration of the treatment course are given individually. The patient's condition, age, type of disease, and its severity are assessed. Before starting treatment, you need to make sure that there is no hypersensitivity to Amoxiclav. It is advisable to have an allergy test done.

Tablets 500 mg + 125 mg

The tableted form of Amoxiclav is prescribed for adults, children who have reached the age of 12. In this case daily dose should not exceed 600 mg.

  • uncomplicated pathology - 1 tab. four times a day;
  • mild infection - 1 tab. twice a day;
  • complicated course of the disease - 1 tab. up to 6 times a day;
  • odotogenic infection - 1 tab. four or twice a day.

If treatment is required by a patient who suffers from liver failure, then between doses it is necessary to increase the break to 12 hours. In case of severe kidney disease, it is recommended to increase the interval between doses up to 24 hours, provided that Amoxiclav is administered intravenously.

Therapy for children is carried out with Amoxiclav in a suspension diluted to measure with distilled water. The permissible dosage per day is up to 45 mg of the penicillin preparation per 1 kg of the child's weight.

Amoxiclav injections

Usually, Amoxiclav injections are given intravenously. In exceptional situations, intramuscular injection is allowed, taking into account the following dose:

  • over 12 years old, the antibiotic is administered at 1.2 g 3 times a day. A severe course is treated with four injection;
  • up to 12 years old, the dosage is calculated individually, based on the weight of the child. For 1 kg of weight, there is 30 mg of Amoxiclav four times a day;
  • for babies up to 3 months, the dosage is calculated from 30 mg per 1 kg of the child's weight twice a day.

Important! The prepared powder for injections must be injected within 15 minutes. The finished solution must not be frozen.

If the expected result is not observed 2-3 days after the start of treatment, then it is necessary to replace the therapeutic tactics with a change in the drug group. Amoxiclav has proven effective only against bacterial infections.

During pregnancy and lactation

The appointment of Amoxiclav to pregnant women is made only if the expected benefit to the expectant mother is higher than the expected harm to the child. Antibiotic therapy is especially harmful in the first trimester.

In the second, third trimester, the medication is prescribed, subject to exact adherence to the dose. The drug is not used during breastfeeding. This is due to the fact that its active components enter the baby's body through breast milk.

Drug interactions

When taking Amoxiclav in parallel with some groups of medicines, the following undesirable reactions may occur:

  • With ascorbic acid the absorption of the antibiotic is accelerated;
  • with laxatives, a slowdown in absorption is noted;
  • with non-steroidal anti-inflammatory drugs, an increased concentration of Amoxiclav is observed;
  • with anticoagulants, the effectiveness of anti-thrombotic agents decreases;
  • with Rifampicin, the antibacterial effect is weakened;
  • with tetracyclines, the effectiveness of antibiotic therapy decreases;
  • with oral contraceptives, their effectiveness may be reduced.

Can I drink alcohol while taking the drug?

It is forbidden to take Amoxiclav at the same time, even with low-alcohol drinks. This can lead to an increase in the negative effect on the liver, an increase in the number of side effects.

Contraindications, side effects and overdose

Before starting the use of Amoxiclav, it is necessary to take into account the presence of the following contraindications:

  • jaundice;
  • lymphocytic leukemia;
  • mononucleosis;
  • an allergic reaction to penicillin-containing drugs;
  • liver disease;
  • kidney disease.

If there is hypersensitivity to active ingredients, the recommended dosage is exceeded, the frequency of use of Amoxiclav is increased, then side effects may develop in the form of:

  • nausea;
  • decreased appetite;
  • diarrhea;
  • vomiting;
  • abdominal pain;
  • itching;
  • skin rash;
  • swelling;
  • anaphylactic shock;
  • dermatitis;
  • jade;
  • headache;
  • dizziness;
  • convulsive state;
  • dysbiosis, causing a fungal infection;
  • resistance of bacteria.

Overdose cases lead to increased side effects, increasing the severity of their manifestations. Usually, an incorrectly calculated dose of Amoxiclav causes vomiting, diarrhea, and nervous agitation. More severe situations are accompanied by seizures. If after taking the symptoms of an overdose, you should call a doctor, do a gastric lavage, take activated charcoal.

For replacement, it is recommended to take the following drugs with a wide spectrum of action:

  • Renclava;
  • Amoxivan;
  • Flemoklava;
  • Augmentin;
  • Panklava.

Replacement of Amoxiclav should be carried out by a doctor, as well as the calculation of the recommended dosage and frequency of administration.

Antibiotic therapy with Amoxiclav helps fight various infections. The medicine is usually well tolerated by patients of different age groups.

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