Norfloxacin ear drops instruction. Instructions for the use of norfloxacin drops and tablets for adults and children, analogues

Norfloxacin is a broad-spectrum antibacterial drug from the group of fluoroquinolones with bactericidal properties.

Release form and composition

Dosage forms of Norfloxacin:

• Film-coated tablets: biconvex, round, yellow color, on a cross-section, the core is light yellow (5 pcs. in a blister contour packing, in a cardboard bundle 2 or 4 packs; 10 pcs. in a blister contour packing, in a cardboard bundle 1 or 2 packs; 20 pcs. in a blister contour packaging, in a cardboard box 1 package; 10 pcs. in a polyethylene can, in a cardboard box 1 can);
• Eye and ear drops: transparent, colorless or pale greenish liquid (5 ml each in vials with a dropper cap, 1 bottle in a cardboard box).

Active ingredient: norfloxacin - 400 mg in 1 tablet; 3 mg / ml solution.

Additional components:

• Film-coated tablets: magnesium stearate, colloidal silicon dioxide, povidone, croscarmellose sodium, microcrystalline cellulose;
• Film shell: yellow iron oxide, titanium dioxide, talc, hyprolose, hypromellose;
• Eye and ear drops: buffer solution, disodium edetate, decamethoxin, sodium chloride, purified water.

Indications for use

• Prostatitis, cystitis, urethritis, pyelonephritis and other infections of the urinary system, in acute and chronic form;
• Gonorrhea;
• Cervicitis;
• Endometritis;
• Traveler's diarrhea;
• Salmonellosis, shigellosis.

Tablets are also prescribed: to prevent recurrence of lesions of the genitourinary tract; for the prevention of infections during surgical interventions and carrying out instrumental diagnostic procedures in urological practice; for the prevention of sepsis (in patients with granulocytopenia).

Eye and ear drops

• In ophthalmology: blepharitis, conjunctivitis, keratitis, blepharoconjunctivitis, dacryocystitis, corneal ulcers, acute inflammation meibomian glands; infections after removing foreign bodies from the cornea or conjunctiva, chemical burns;
• In otolaryngology: otitis externa, otitis media (acute and chronic form).

Also, drops are used in operations on the organs of vision and hearing to prevent infectious complications.

Contraindications

• Terminal stages renal failure;
• Liver failure;
• Deficiency of glucose-6-phosphate dehydrogenase;
• Age up to 15 years;
• Pregnancy and lactation;
• Hypersensitivity to the components of the drug and other drugs of the fluoroquinolone series.

Method of administration and dosage

Film-coated tablets

The tablets are taken orally 2 hours before meals, swallowing whole and drinking plenty of water.

The dosage regimen is prescribed individually depending on the indications, the patient's condition and the tolerance of the agent. A single dose is usually 400-800 mg (1-2 tablets) divided into 1-2 doses. Doses for adolescents over 15 years of age are the same as for adults.

When treating infections urinary tract it is recommended to take 400 mg (1 tablet) 2 times a day for 7-10 days; for the treatment of uncomplicated cystitis, the course is 3-7 days; with chronic recurrent forms of urinary tract infections - up to 3 months.

For the treatment of gonococcal urethritis, proctitis, cervicitis, the drug is taken once, 800 mg (2 tablets).

To prevent diarrhea, travelers are recommended to take the drug in a daily dose of 400 mg the day before departure and throughout the trip (no more than 3 weeks).

In order to prevent bacterial gastroenteritis, the agent is prescribed at a dose of 400 mg once a day, sepsis - 2 times a day.

To prevent recurrence of urinary tract lesions, 200 mg of the drug are taken per day.

Patients on hemodialysis, as well as with creatinine clearance below 20 ml / min, are prescribed 2 times a day for ½ the recommended therapeutic dose, or 1 time per day full dose.

Eye and ear drops

Drops are used mainly in combination with systemic antibacterial therapy... The liquid should be warmed to body temperature before use.

For eye lesions, the drug is administered in 1-2 drops. In the case of acute infectious diseases, instillations are carried out every 15-30 minutes (in the future, their frequency is reduced), with moderate processes - no more than 6 times a day. For the treatment of trachoma, 2 drops are prescribed 2-4 times a day for 1-2 months.

In case of diseases of the ear, after the rehabilitation of the external auditory canal, the drug is administered 2-5 drops up to 3 times a day. To facilitate the administration of the drug, the patient is advised to lie on one side or tilt his head and hold it in this position after instillation for 2 minutes. In the future, you can put a cotton swab into the ear canal.

After the signs of infection disappear, the drops must be used for the next 2 days.

Side effects

• Digestive system: decreased appetite, bitterness in the mouth, nausea, diarrhea, abdominal pain or cramps, dysbiosis, pseudomembranous colitis, increased activity of hepatic transaminases;
• Nervous system: insomnia or drowsiness, dizziness, headache; rarely - disorientation, convulsions, hallucinations; in old age - fatigue, irritation, tinnitus, depression, anxiety, fear;
• Urinary system: profuse urination, dysuria, bleeding from the urethra, crystalluria, glomerulonephritis, increased levels of creatinine and urea in the blood plasma, the appearance of protein in the urine;
• Skin: itching, rash, urticaria, edema, photosensitivity, toxic epidermal necrolysis, malignant exudative erythema;
• Musculoskeletal system: joint pains, tendon ruptures and inflammations;
• The cardiovascular system: tachycardia, arrhythmia, vasculitis, arterial hypotension;
• Allergic reactions: respiratory failure, anaphylaxis, Quincke's edema;
• Hematopoietic organs: leukopenia, thrombocytopenia, eosinophilia, neutropenia;
• Local reactions: edema and hyperemia of the conjunctiva, pain or burning sensation, photophobia.

When oral administration In case of an overdose of Norfloxacin, it is necessary to induce vomiting or to lavage the stomach with a probe, to ensure the flow of a large amount of fluid into the body (to prevent crystalluria), to establish control over water-salt metabolism. Treatment is symptomatic.

There are no reports of drug overdose in otology and ophthalmology.

special instructions

The drug should be used with extreme caution in case of atherosclerosis of cerebral vessels, functional disorders of the liver / kidneys, epilepsy.

During the period of therapy, it is necessary to consume a sufficient amount of fluid (under the control of diuresis).

When Norfloxacin is combined with antacids, as well as preparations containing calcium, magnesium, zinc, iron or sucralfate, the interval between their intake should be at least 2 hours.

Against the background of therapy, there may be an increase in the prothrombin index (if necessary surgical intervention monitoring of the state of the blood coagulation system is required).

You should immediately stop taking the drug and consult your doctor if you experience allergic reactions, pain in the tendons, signs of bronchospasm.

After the introduction of drops into the eyes for the next 30 minutes, you must refrain from driving vehicles or other complex mechanisms.

During treatment, prolonged exposure to direct sunlight should be avoided.

Drug interactions

The mutual influence of norfloxacin and drugs / substances when used simultaneously:

• Theophylline - increases its level in the blood, reducing the clearance by 25%;
• Cyclosporine - helps to increase its concentration in serum;
• Warfarin - enhances its anticoagulant effect;
• Drugs that lower the epileptic threshold - can contribute to the development of epileptiform seizures;
• Antacids, drugs containing calcium, magnesium, iron, zinc or sucralfate - reduce the absorption of norfloxacin;
• Drugs that have an antihypertensive effect - can lead to a sharp decrease in blood pressure;
• Nitrofurans - reduces their effectiveness;
• Caffeine - slows down the period of its elimination from the body.

When combining norfloxacin with antihypertensive drugs, anesthetics, barbiturates, it is required to monitor the heart rate, blood pressure, and electrocardiogram indicators.

Terms and conditions of storage

Store in a place protected from light, out of reach of children. Tablets - at a temperature not exceeding 25 ° C, drops - from 15 to 25 ° C. The shelf life of drops after opening the bottle is no more than 10 days.

Shelf life is 2 years.

Norfloxacin belongs to the synthetic antibiotics of the fluoroquinolone group. It is often prescribed by specialists for the treatment of inflammatory and infectious diseases, as it works against many pathogenic bacteria. However, for therapeutic effect, before using the drug, you must read the instructions for use of Norfloxacin.

The medicine is produced in the following dosage forms:

• ophthalmic and ear drops;
• pills.

The drops are a clear solution. The liquid has a slightly greenish tint.

The tablets are film-coated. Their color is white, they can be yellowish. They are packaged in a cardboard box of 10 pieces.

The active ingredient of the drug is norfloxacin ( latin name - norfloxacin). The tablets contain additional substances:

• potato starch;
• cellulose;
• calcium hydrogen phosphate;
• lactose monohydrate;
• talc;
• crospovidone;
• titanium dioxide;
• calcium stearate.

One tablet contains the active substance in a dosage of 400 mg. In 1 milliliter of drops - 3 milligrams of norfloxacin.

Pharmacological action of the drug

Norfloxacin inhibits the growth and reproduction of such gram-negative microbes:

• klebsiella;
• proteas;
• enterobacteriaceae;
• streptococci;
• shigella;
• salmonella;
• staphylococci.

Pharmacodynamics and pharmacokinetics of the drug

The drug helps to inhibit the activity of DNA gyrase in bacterial cells. Possesses wide range antimicrobial effects.

Drug substances are quickly absorbed by the organs digestive tract... The concentration of the active ingredient in the blood plasma is observed within 60-120 minutes after using the drug.

About 15% of the substance binds to plasma proteins.

It is excreted from the body unchanged, during urination and defecation, throughout the day.

Indications for use

The drug in tablets is prescribed for complex treatment such pathologies of the urinary organs:

• pyelitis;
• pyelonephritis;
• cystitis;
• gonorrhea;
• urolithiasis disease;
• cystopyelitis.

Norfloxacin is used for these diseases in acute or chronic form.

The drug is used for urinary tract infections after surgery or urological procedures.

The tablets are prescribed for patients with weak immune system and with neutropenia in order to prevent infectious diseases that can provoke gram-negative bacteria.

Drops are used when infectious diseases middle ear and eyes.

Instructions for the use of Norfloxacin

The method of administration and dosage of the drug depend on dosage form Norfloxacin.

Pills

The tablets are intended for internal use.

You can take the tablets once a day, at the same time of day. However, it is best to drink the drug twice - in the morning and in the evening.

The dosage and course of therapy is prescribed by a specialist, depending on the severity of the pathology, as well as the individual characteristics of the patient.

Drops

Drops are intended for instillation of eyes and ears.

The dosage depends on the severity of the disease:

1. For acute eye infections, two drops are prescribed in each eye every half hour. Then the frequency of instillation is reduced.
2. Usually, for eye diseases, it is necessary to bury the eyes up to six times a day, 1-2 drops.
3. For the treatment of ear diseases, it is necessary to bury the ear canals 5 drops three times a day.

Features of use for children

IN childhood pills are prohibited.

Norfloxacin drops are not prescribed for children under 15 years of age.

Use for pregnant women and breastfeeding

The period of bearing a child is a contraindication for the use of Norfloxacin.

Due to the property active substance to penetrate into breast milk is not recommended to use the drug for nursing mothers.

If necessary, treatment with the drug should stop breastfeeding. The use of drops during this period can be prescribed by a doctor if the benefit to the woman is higher than the risk to the fetus.

Use in renal or hepatic impairment

With hepatic and renal failure, use the drug with caution. The specialist can adjust the dosage.

Treatment with pills should take place under medical supervision.

Excess dosage

When using exceeded dosages of tablets, the following symptoms may develop:

• dyspnea;
• thrombocytopenia;
• fever;
• high temperature;
• leukopenia;
• renal failure;
• dyspeptic disorders.

Allergic reactions may occur in the form of swelling, redness and rashes on skin, anaphylactic shock.

If such signs of an overdose are observed, then it is necessary to stop taking the tablets and drink a solution that contains calcium.

In case of an acute overdose, the patient must be examined. Symptomatic therapy is also prescribed.

Side effects

An antibiotic can cause side effects. These reactions include:

• dyspeptic disorders;
• allergy;
• dizziness;
• headache.

If these reactions occur, the drug is discontinued. In this case, a specialist consultation is required.

In what cases is the drug contraindicated?

It is not allowed to take pills in the following cases:

• tendon ruptures;
• individual hypersensitivity to substances of the agent.

The medicine is not prescribed for pregnant women, children and nursing mothers.

Special instructions of the medicinal product

Since quinolones can increase photosensitivity, you should not be in the sun during the period of drug treatment long time... To prevent photosensitivity, do not go to the solarium.

It is advisable to refrain from driving complex mechanisms and vehicles during treatment with Norfloxacin.

Drops are used with caution to treat patients with epilepsy, as well as atherosclerosis.

Because of the risk of tendon problems, older people are treated with caution and under medical supervision with Norfloxacin. Dosage adjustments are required in patients after heart or kidney transplant.

Interaction with other substances

When taken simultaneously with other drugs, the following reactions are observed:

• Nitrofuran - Norfloxacin reduces the effectiveness of the substance;
• antacids - can reduce the absorption of Norfloxacin;
• Warfarin - the anticoagulant effect is enhanced;
• Glibenclamide - hypoglycemia is provoked;
• anti-inflammatory non-steroidal drugs - development of a convulsive state, increased excitation of the central nervous system is possible;
• Theophylline - the likelihood of side effects increases.

With the simultaneous use of Norfloxacin with agents of the cyclosporin group, the level of the latter in the blood plasma increases.

Conditions of dispensing from pharmacies and the cost of the drug

Norfloxacin is available on a prescription basis.

The price of the medicine is from 130 to 250 rubles.

Rules and shelf life of medicines

• a place where direct rays of the sun do not penetrate;
• optimal temperature regime - no more than 25 degrees;
• humidity - 75%;
• a place hard to reach for children.

The shelf life of the medicine is 3 years. After this time, the use of the drug is not allowed.

An open bottle of drops can be stored for no more than 10 days.

Norfloxacin analogs

Drug analogues include:

• Norilet;
• Nolitsin;
• Negaflox;
• Loxon 400;
• Norflock;
• Normax;
• Sophazin;

These substitutes are identical in composition and pharmacological effect.

Norfloxacin is a powerful antibiotic, effective in the treatment of infectious diseases caused by gram-negative bacteria. Therefore, it is important to remember that the specialist prescribes this drug. Self-medication can aggravate the situation and cause unwanted consequences.

Registration certificate
UA / 4901/01/01

NORFLOXACIN

Eye and ear drops

Tradename

NORFLOXACIN

International name

Norfloxacin

Latin name

general characteristics

Composition of the medicinal product:

active substance: norfloxacin; 1 ml of solution contains 3 mg norfloxacin (0.003 g);

excipients: sodium chloride, decamethoxin, disodium edetate, buffer solution, purified water.

Release form

Eye and ear drops

Pharmgroup

Antibacterial agent of the fluoroquinolone group.

Pharmacological properties

Norfloxacin - antimicrobial agent fluoroquinolone groups; inhibits the activity of bacterial cell DNA-gyrases, stops bacterial DNA replication.

Norfloxacin has a broad spectrum of antimicrobial activity relative to the vast majority of gram-negative microorganisms.

Indications for use

Norfloxacin is used to treat superficial eye infections (bacterial conjunctivitis, keratitis, blepharitis), infections of the outer and middle ear (otitis externa, chronic purulent

otitis media).

Method of administration and dosage

The dose, frequency and duration of use is determined individually by the doctor!

Eyes.

In acute infectious diseases of the eyes, the drug is instilled in 1 - 2 drops every 15 - 30 minutes, then the frequency of instillations is reduced.

With a moderately pronounced process, instill 1 - 2 drops 2 - 6 times a day. In acute and chronic trachoma, 2 drops are instilled into each eye 2 to 4 times a day for 1 to 2 months.

In case of ear diseases, 5 drops are instilled into the ear 3 times a day. The drops should be at body temperature. Before using the drops, you should sanitize the external auditory canal.

The patient should lie on his side or tilt his head to facilitate instillation. After instillation, the head should be kept in this position for about 2 minutes. In the external auditory passage, you can

put a cotton turunda.

After the disappearance of the symptoms of the disease, the use of the drug should be continued for the next 48 hours.

Side effects

Local reactions are possible (burning sensation or pain, hyperemia and edema of the conjunctiva, photophobia). Consult your doctor in the event of adverse events or unusual reactions.

regarding the further use of the drug.

Contraindications

Hypersensitivity (allergy) to norfloxacin and other fluoroquinolone drugs.

Pregnancy and lactation.

Children and adolescents up to 15 years old.

Interaction with other medicinal products

If you are taking any other medicines, be sure to consult your doctor regarding the possibility of using the drug!

Interaction with other medicinal products for local application Norfloxacin has not been described.

Overdose

There were no reports of Norfloxacin overdose in ophthalmology and otology.

In case of accidental ingestion of drops inside, nausea, vomiting, diarrhea, headache, dizziness, and anxiety are observed. In this case, you should consult a doctor.

Application features

Before starting treatment, consult your doctor!

Norfloxacin drops are for topical use only.

To achieve the best therapeutic effect drops should be used in combination with systemic antimicrobial therapy (except in mild cases).

Patients with epilepsy use drops of Norfloxacin with caution, convulsive syndrome other etiology, with severe impaired liver / kidney function, with atherosclerosis, cerebral vessels

The development of photophobia is possible; should be worn sunglasses and avoid prolonged exposure to bright light.

For 30 minutes after instilling the drug in the eyes, you should refrain from driving and practicing potentially dangerous species activities that require increased

attention.

Storage conditions and periods

Shelf life. 2 years. The shelf life of the solution after opening the bottle is 10 days.

Store out of the reach of children, protected from light at a temperature of 15 C to 25 C.

Vacation conditions

On prescription

Packaging

5 ml vials with dropper cap.

Manufacturer and its address

Branch of LLC "Experimental plant" GNTSLS ". Ukraine, 61057, Kharkov, Vorobyov st., 8.

Eye drops Norfloxacin - antibacterial drug, which has a wide range of activities. In ophthalmology, it is used for inflammatory diseases eye. Norfloxacin is also prescribed for patients suffering from infectious diseases genitourinary system (cystitis, pyelonephritis, urethritis and prostatitis), diseases of the gastrointestinal tract (salmonellosis). Drops of Norfloxacin are used by otolaryngologists for inflammatory processes in the outer and middle ear.

Composition, release form

Norfloxacin - medicinal product, which belongs to the group of fluoroquinolones. It is the main active ingredient of the same name eye drops... They also include the following auxiliary ingredients: purified water; sodium chloride; Trilon B; decamethoxin; a buffer solution having a pH of 4.7.

Norfloxacin eye drops are a clear or slightly greenish liquid. They are available in 5 ml dispenser vials. 1 ml of solution contains 3 mg of norfloxacin.

pharmachologic effect

Norfloxacin exhibits bactericidal activity against many microorganisms. It blocks the replication of bacterial DNA, as a result of which their reproduction is inhibited. This antiseptic exhibits bactericidal activity against such gram-positive and gram-negative microorganisms:

• enterococci;
• streptococci;
• staphylococci;
• enterobacteria;
• klebsiella;
• escherichia;
• proteas;
• pseudomonas;
• shigella;
• salmonella;
• yersinia.

It also acts on Pseudomonas, Vibrio cholerae and Ureaplasma.

Norfloxacin is resistant to the action of β-lactamases - enzymes of microorganisms that can destroy its structure. The drug is inactive against treponema pallidum (the causative agent of syphilis) and is able to hide the signs of the disease, which follows when it is used in the treatment of syphilitic damage to the organs of vision.

When using such a dosage form of norfloxacin as ophthalmic and ear drops, antibacterial agent acts directly at the site of injury, which allows you to achieve a quick and best result treatment. The drug begins to act 1 hour after the instillation of eye drops, and the maximum concentration of the active substance is noted after 2 days. It is absorbed into the bloodstream and is well processed by the liver, and excreted from the body by the kidneys.

Indications for use

Norfloxacin eye drops are prescribed in ophthalmic practice for the following eye diseases:

• and keratoconjunctivitis;
• blepharitis and blepharoconjunctivitis;
• defeat;
• inflammation of the meibomian glands in the acute period;
• after eye surgery;

They are also prescribed after extraction foreign body of eyeball and ear, as well as in ENT practice with external and otitis media. The drug is also used after removing a foreign body from the eye and ear, after surgery.

Method of administration and dosage

Eye drops Norfloxacin are prescribed for adults and children who have reached the age of fifteen, 1-2 drops in the conjunctival sac every 15-30 minutes. Then, with a decrease in the symptoms of inflammation, the frequency of instillations is reduced. After the signs of the disease disappear, the procedures should be performed for another 2 days.

If inflammatory process expressed moderately, then it is enough to instill 1-2 drops of Norfloxacin eye drops after 4-12 hours. In the case of acute or chronic trachoma, the course of treatment is from 1 to 2 months, 2 drops of the drug 2-4 times a day.

Contraindications

Norfloxacin eye drops are not prescribed for children under 15 years of age. There is evidence of the penetration of the main active substance through the placenta and into breast milk, therefore, the drug should not be used by burdened and breastfeeding women. This can lead to impairment of the health of the fetus and newborn baby. If there is a need to use Norfloxacin eye drops during lactation, breastfeeding should be avoided during drug treatment.

The drug is contraindicated in the presence of a history of norfloxacin intolerance. It is not prescribed for viral and fungal eye infections.

Side effects

When using Norfloxacin eye drops, some patients may experience allergic reactions in the form of skin rashes, Quincke's edema, hypersensitivity to sunlight, itching, burning, puffiness and discomfort in the eye. After using the drug, exudative erythema sometimes developed.

In some cases, with topical use of Norfloxacin eye drops, patients have observed such side effects:

• bitterness in the mouth;
• heartburn;
• nausea;
• stomach ache;
• sense of anxiety;
• dizziness.

Overdose

No cases of overdose of Norfloxacin eye drops with their topical application have been reported. In case of accidental ingestion of the drug, nausea, vomiting, stool disorder, headache and dizziness may occur. Since there is no antidote to norfloxacin, if an overdose of the drug is suspected, it is necessary to flush the stomach, give a cleansing enema and give the patient to take sorbents.

Interaction with other drugs

When Norfloxacin eye drops are applied topically with other ophthalmic drugs, they do not interact with each other. However, if it becomes necessary to instill several medicines, a fifteen-minute interval between treatments should be observed.

Storage conditions and special instructions

It is recommended to store Norfloxacin eye drops in a dark place, to which children should not have access, at room temperature. After opening the bottle, its contents should be used within 10 days. Norfloxacin eye drops are not intended for oral administration.

After instillation of the drug, the quality of vision may sometimes be temporarily impaired. In this regard, before him full recovery must be driven with care vehicles and work with mechanisms that require high concentration of attention.