Instructions for use. Quamatel Analogs and price contraindications for use

Most frequent complications from side digestive tractfound in the practice of a gastroenterologist's doctor, are erosive-ulcerative lesions of the gastrointestinal tract and associated with this internal bleeding. Rhythmic life rhythm is a source of mass of all kinds of stressful factors, which, in turn, stimulate the release of corticosteroids, adrenocorticotropic hormone, histamine, catecholamines. This biochemical cocktail in excessive amounts does not carry anything good in itself, stimulating the hypersection of hydrochloric acid and pepsin, shifting the pH into the acidic side and reducing the protective potential of the stomach mucosa. In such cases, the need to prevent such situations to the fore, where its main tool is medical therapy Preparations that reduce the acidity of the stomach. Being blocker histamine receptors third generation original preparation Quamatel (MNN - Famotidine) from the Hungarian Pharmaceutical Plant "Gideon Richter" on the right occupies one of the prominent places in the list of anti-sized drugs.

The main therapeutically significant pharmacological effect Quamatel is suppressing the secretion of gastric juice both in a quantitative (secretion volume) and in a qualitative (hydrochloric acid concentration) of expression. In addition, the drug strengthens the "protective bastions" of the gastric mucosa by activating blood flow in it, increasing the production of bicarbonate salts, activation of the recovery of the epithelium.

The popularity of quamatels among specialists and patients is related to the lack of a number of shortcomings in its predecessors, plus the presence of several undeniable advantages in its "personal case" of several indisputable advantages actively announcing the manufacturer. So, the effective dose of this drug - 40 mg is significantly less than that of ranitidine and cimetidine. And the duration of action is greater (10-12 hours against 7-8 hours in ranitidine and 5-6 hours at cimetidine). Among the others positive qualities Quamatel - Minimum Quantity side Effects, the probability of the appearance of which does not exceed 1%. The drug does not interfere with the work of the liver and male sex glands, does not cause gynecomastia, does not increase bioavailability alcoholic beverages (Therefore, it can be used in persons abusing alcohol).

Quamatel produced in two dosage forms: Tablets and lyophilisate for the preparation of a solution for intravenous (exclusively intravenous!) Introduction. Availability injection form You can also record the advantages of the quamatel. The drug quickly relieves pain when acute attacks peptic disease Stomach and 12 pans. For oral reception Quamatels in a daily dose of 40 mg pain is bought within 7 days in 66% of patients. When injecting 20 mg 2 times a day, the disappearance of pain syndrome can be expected already on 3-4 day therapy.

An important condition for the prescription of the quamatel is a preliminary study of the digestive tract for the absence of malignant neoplasms.

Pharmacology

Gistamine H 2-receptor blocker. Reduces basal and stimulated with gastrine, pentagastrine, betazole, caffeine, histamine, acetylcholine and physiological vagus reflex secretion of hydrochloric acid. At the same time, the pH increases and the activity of pepsin is reduced. Practically does not affect the levels of gastroy on an empty stomach and after meals. Does not affect the motility of the stomach, the exocrine activity of the pancreas, blood circulation in the portal system, at the levels of hormones, does not have antidrogenic action.

Famotidine poorly affects liver microsomal enzymes.

After taking the drug inside the action occurs after 1 hour, the maximum of action - after 3 hours after taking, the duration of the effect ranges from 12-24 hours, depending on the dose.

The preparation in the form of lyophilisate for the preparation of a solution for B / in administration after administration in a single dose of 20 or 40 mg in the evening suppresses basal and night secretion for 10-12 hours.

Pharmacokinetics

Pharmacokinetics is linear.

Suction

After taking inside, it is absorbed from the gastrointestinal tract. C MAX is achieved after 1-3 hours and is 0.07-0.1 mg / l. Bioavailability - 40-45%, increases with simultaneous meals and decreases with simultaneous reception of antacids.

Distribution

Binding with plasma proteins is 10-20%. Penetrates the placental barrier and through the BC. Stands out with breast milk.

Metabolism

30-35% of the drug is metabolized in the liver with the formation of S-oxide.

Election

T 1/2 is 2.3-3.5 hours after taking inside of 30-35% of Famotidine, and after B / in the administration of 65-70%, the Famotidine is removed with the urine unchanged.

Pharmacokinetics in special clinical cases

With QK<10 мл/мин T 1/2 может достигать 20 ч.

Form release

Tablets coated with film shell of pink color, convex, with engraving "F20" on one side; On a white or almost white ished.

Auxiliary substances: silicon colloidal dioxide, magnesium stearate, povedium K90, sodium carboxymethyl starch (type A), talc, corn starch, monohydrate lactose.

The composition of the shell: iron oxide red, silicon dioxide colloid, titanium dioxide, macrogol 6000, sepilm 003 (Macroogol-40 OE stearate (E431), microcrystalline cellulose (E460), hypimloose (E464)).

14 pcs. - Blister (2) - cardboard boxes.

Dosage

For receiving inside

With the ulcer of the stomach and duodenum in the quamatel ® exacerbation phase are prescribed at a dose of 40 mg 1 time / day before bedtime or 20 mg 2 times / day, in the morning and in the evening. If necessary, the daily dose can be increased to 80-160 mg. The duration of the course of treatment is an average of 4-8 weeks.

In order to prevent the exacerbations of the stomach ulcer and duodenal sickness of the quamatel ®, are prescribed at a dose of 20 mg 1 time / day before bedtime.

In reflux-esophagitis, the drug is prescribed at a dose of 20 mg 2 times / day (in the morning and evening) for 6 weeks; If necessary, 40 mg 2 times / day.

In the Zolinger-Ellison syndrome, the initial dose is 20-40 mg every 6 hours; If necessary, the daily dose can be increased to 240-480 mg. The duration of the drug depends on the clinical state of the patient.

In order to prevent the aspiration of gastric content during the general anesthesia, quamatel ® are prescribed at a dose of 40 mg on the eve of the operation and / or in the morning per day of operation.

For in / in administration

Quamatel ® is used in / B, stove or drip only in severe cases or if it is impossible to receive the drug inside.

Designed only for use in the hospital. At the first opportunity, you should switch to the oral intake of Famotidine. The average dose is 20 mg 2 times / day (every 12 hours). One-time dose should not exceed 20 mg.

With Zolinger Ellison syndrome, the initial dose is 20 mg every 6 hours, in the further dose of the drug, depending on the secretion of hydrochloric acid and the patient's clinical state.

For the prevention of aspiration of gastric content before carrying out general anesthesia, 20 mg of the drug is administered on the eve of the operation or at least 2 hours before the operation.

Patients with impairment of kidney function (QC less than 30 ml / min), or with the level of creatinine serum more than 3 mg / dl, daily dose of the drug (both for intake and for in / in administration) decrease to 20 mg or increase the interval Between the use of individual doses of the drug to 36-48 hours.

Rules of preparation and administration of solutions for injection

To prepare the solution, the contents of one ampoule with the active substance should be pre-diluted in 5-10 ml of saline (ampoule with solvent). The prepared solution retains stability at room temperature for 24 hours. The drug is injected for at least 2 minutes. When in / in drip administration, the duration of the infusion should be 15-30 minutes. The solution should be prepared immediately before administration.

Overdose

Symptoms: vomiting, motor arousal, tremor, decreased blood pressure, tachycardia, collapse.

Treatment: stomach wash, symptomatic and supporting therapy; hemodialysis.

Interaction

Due to the increase in the pH of the contents of the quamatel ® stomach, with simultaneous use, reduces the absorption of ketoconazole and itraconazole; Increases absorption of amoxicillin and clavulanic acid.

Antacids and sucralfat, used simultaneously with the quamatel, slow down the absorption of Famotidine.

With simultaneous reception of quamatels and drugs, depressing bone marginal blood, increases the risk of neutropenia.

Side effects

From the digestive system: dry mouth, nausea, vomiting, abdominal pain, meteorism, constipation, diarrhea, decreased appetite; Improving the activity of liver transamamine, hepatocellular, cholestatic or mixed hepatitis, acute pancreatitis.

From the side of the blood formation system: very rarely agranulocytosis, sheltering, leukopenia, thrombocytopenia, hypo-or aplasia of bone marrow.

Allergic reactions: urticaria, skin rash, itching, bronchospasm, angioedema edema, anaphylactic shock.

From the side of the cardiovascular system: arrhythmia, bradycardia, AV blockade, decreased blood pressure.

From the CNS: Headache, dizziness, drowsiness, hallucinations, confusion, increased fatigue, depression, excitement, anxiety.

From the sides of the senses: a decrease in visual acuity, noise in the ears.

From the side of the sexual system: with long-term use in high doses - hyperprolactinemia, gynecomastia, amenorrhea, a decrease in libido.

On the part of the musculoskeletal system: arthralgia, muscle spasms.

Dermatological reactions: alopecia, ordinary acne, dry skin, toxic epidermal necroliz.

Others: Fever.

Indications

• ulcerative duel of duodenal and stomach in the exacerbation phase, recidiva prevention;
• treatment and prevention of symptomatic ulcers of the stomach and duodenum (associated with the reception of NSAIDs, stressful, postoperative ulcers);
• erosive gastroduodenitis;
• functional dyspepsia associated with an increased secretory function of the stomach;
• reflux-esophagitis;
• zollinger-Ellison syndrome;
• prevention of recurrence of bleeding from the upper gastrointestinal departments;
• prevention of aspiration of gastric juice with general anesthesia (Mendelssohn syndrome).

Contraindications

• pregnancy;
• lactation period (breastfeeding);
• childhood;
• increased sensitivity to the components of the drug;
• increased sensitivity to other histamine H 2-receptor plants.

Caution should be prescribed the drug with renal and liver failure, with a liver cirrhosis with portoystene encephalopathy in history.

Features of application

Application in pregnancy and breastfeeding

Application with violations of liver function

If the liver function is impaired, the drug is prescribed with caution, reduced doses.

Application with violations of the kidney function

Patients with impairment of kidney function (QC less than 30 ml / min), or with Creatinine Creatinin levels of more than 3 mg / dl, daily dose of the drug (both for intake, and for in / in administration) decrease to 20 mg or an interval Between the use of individual doses of the drug to 36-48 hours.

special instructions

The use of the quamatel may disguise the symptoms of the stomach cancer, therefore, before proceeding with the treatment of Famotidin, it is necessary to eliminate the presence of a malignant neoplasm.

With a sharp discontinuation of the treatment, Famotidin may cause cancellation syndrome, so treatment is stopped, gradually reducing its dose.

Patients with violations of the liver function Kvamatel ® should be prescribed with caution and lower doses.

With long-term treatment of weakened patients or patients under stress conditions, bacterial gastric lesions are possible with the further spread of infection.

Quamatel ® should be taken 2 hours after receiving antenzola or ketoconazole in order to avoid a significant reduction in their suction. 1-2 hour break between the quamatel and antacids reception should also be observed.

Gistamine H 2 Blockers -receptors (including quamatel ®) may inhibit the acid-containing effect of pentagastrine and histamine, so 24 hours before the test, it should be refused the quamatel destination.

Gistamine H 2 blockers are receptors can suppress the skin reaction to histamine, thus leading to false negative results. Therefore, before conducting diagnostic skin samples to detect an allergic skin reaction of an immediate type of quamatel ®, you should cancel.

During treatment, the use of food, beverages and other drugs can be used, which can cause irritation of the stomach mucosa.

Impact on the ability to driving vehicles and control mechanisms

During the reception of the drug quamatel ® patients, caution should be taken when controlling vehicles and classes with potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Instruction

for the use of funds

Quamatel

Form release

Tablets, ampoules, powders

Pharmacological properties

Famotidine is a powerful competitive inhibitor of H2-histamine receptors. The main clinically significant pharmacological effect of Famotidine is to inhibit gastric secretion. Famotidine reduces both the acid concentration and the volume of gastric secretion, while the production of pepsin remains proportional to the volume of the selected gastric juice.

Both healthy volunteers and in patients with hypersection, Famotidin inhibits both basal and night and stimulated by pentagastrine, betazole, caffeine, insulin, or physiological vagal dephlex secretion.

The duration of inhibition of secretion when applying doses 20 and 40 mg is 10-12 hours.

One-time oral administration of doses of 20 and 40 mg in the evening ensures inhibition of basal and night secretion of hydrochloric acid.

Famotidin practically does not affect the level of gastroin on an empty stomach or after meals.

Famotidine does not affect the emptying of the stomach, the exocrine function of the pancreas, the blood flow in the liver and the portal system.

Famotidin does not affect the enzyme system of cytochrome P450 liver.

The antagandogenic effect of the drug is not marked. The level of plasma hormones after treatment with Famotidine has not changed.

Indications

Benign stomach ulcer. Duodenal ulcer. The states of hypersecretion, Zolinger - Ellison syndrome. Treatment of gastroesophageal reflux disease. Prevention of aspiration of acidic gastric content (Mendelssohn syndrome) during general anesthesia.

Contraindications

Increased sensitivity to any component of the drug and other antagonists of H2-histamine receptors; Children's age, period of pregnancy and breastfeeding (due to lack of necessary clinical experience).

Application in pregnancy and breastfeeding

Khamatel is contraindicated to women at the stage of battery and lactation.

Structure

1 Vials of the quamatel preparation in the form of lyophilized injection powder contains:

Famotidine - 20mg;

Excipients.

1 ampoule with solvent contains:

Sodium chloride solution 0.9% - 5ml;

1 tablet covered with a shell, a quamatel 20 preparation contains:

Famotidine - 20mg;

1 Tablet covered with a shell, the preparation of quamatel 40 contains:

Famotidine - 40mg;

Auxiliary substances, including lactose monohydrate.

1 tablet covered with shell, quamatel mini preparation contains:

Famotidine - 10mg;

Auxiliary substances, including lactose monohydrate.

Method of application and dose

Quamatel in tablets is designed for oral administration. The recording and duration of the treatment is selected by the doctor individually, taking into account clinical indicators. When the ulcer of the duodenal and the gastric ulcer and the stomach, the press is taken by PO 40 mg times in Cyti and preferably in the evening, or Po 20 mg twice in the war. If necessary, the drug may be used to 160 mg. The duration of treatment can vary from 4 to 8 weeks.

To prevent the development of the development of ulcerative disease, Zhewyka drug should be filled with 20 mg one of the day per day. With therapy of reflux-esophagitis, 20 mg of the drug should be taken 2 times a day for 6 weeks, if the starting dose does not succeed in achieving the necessary therapeutic effect, the dose of the drug can be increased to 80 mg.

The lyophilisate for the preparation of the solution is intended for intravenous drip or inkjet administration solely in the hospital. The drug is used to treat severe forms of the disease or if it is impossible to receive quamatel in oral form. Before administration, the contents of the vial are divorced in 5 or 10 ml of solvent.

Side effects

The quamatel treatment may be accompanied by the development of nausea, vomiting, decreased appetite, violation of the chair, the meteorism, dryness of the mucous membrane, emotional lability, increased anxiety, hallucinations, violation of cardiac rhythm, dizziness, increasing body temperature and muscle gain.

Interaction with other drugs

Suction of certain drugs (for example ketoconazole, amoxicillin, iron preparations) depends on the acidity of the gastric juice. Therefore, Famotidin must be used at least 2 hours after receiving such medicines.

Simultaneous use with other H2 receptor antagonists can significantly reduce the effectiveness of Tolazolin. Although there are no confirmed interactions between the Famotidine and Tolazolin, the likelihood of their existence is high enough, so the effect of Tolazoline should be determined at the beginning and after the completion of the concomitant treatment. In the event of a reduction in the effect of Tolazolina, the dose should be gradually raised or stopped with Famotidin.

Food and antacids do not have a significant impact on Famotidin treatment.

Famotidin does not affect the hepatic system of cytochrome P450 oxidase, therefore the metabolism of oral anticoagulants, antiprin, amineopyrin, theophylline, phenyotine, diazepam, ethanol and propranolol remains unchanged.

Sampleclip can slow down the release of Famotidine.

Overdose

With the use of Famotidine during the year at a dose of 800 mg / day in patients with hypersecretions of the gastric juice, severe side effects are not revealed.

Symptoms: vomiting, motor arousal, tremor, decreased blood pressure, tachycardia, ventricular arrhythmia and collapse can develop.

Treatment: symptomatic and supporting therapy is used if necessary - in the introduction of diazepam in case of convulsion, atropine during bradycardia and lidocaine in the case of ventricular arrhythmia. Hemodialysis is effective. Observation of the patient's condition.

Storage conditions

Shelf life

Quamatel - RLS tablets, which is used in gastroenterology. It is not possible to purchase it independently. To buy a patient, you need to receive a recipe for a doctor, as well as to get acquainted with the instructions.

Sheet-insert

The quamatel preparation is prescribed to the patient in different forms: pills and lyophilisate for injection. The medical recipe necessarily indicates which form of release is necessary to the consumer:

• mini quamatel tablets - 10 mg of the active substance;
• Quamatel 20 (in tablets) - contains 20 mg of active ingredients;
• Quamatel 40 - contain, respectively, 40 mg of medication;
• Quamatel ampoules - 20 mg in each bottle.

The active substance of the drug is Famotidin. It contributes to the locking of histamine receptors located on the surface of the mucous membrane of the stomach and intestines. Thus, the quamatel medicine reduces the extraction of hydrochloric acid, which disrupts the digestion and damages the walls of the gastric path. A non-proprietary pharmotidine drug also reduces the negative effect of pepsin.

The medicine is prescribed also because it does not affect the stomach motor. The natural work of the stomach allows you to move food to the intestines in time. Treatment helps to reduce acidity, at the same time without affecting the pancreas enzymes, liver and human hormonal background.

Indications and contraindications

Guide to the use of quamatels must be obtained from a specialist. After the survey conducted, the doctor will select an individual dosage for the patient and tell about the peculiarities of the drug. Each potential consumer needs to study a leaf-insert, which is attached to the quamatel tool. The application instruction describes the following indications for use:

• ulcerative lesions of the stomach or intestines (in the acute stage), prevention;
• gastroduodenitis erosive form;
• reflux;
• syndromes Zolinger Ellison or Mendelssohn;
• prevention of bleeding from the upper digestive systems;
• dyspeptic disorders arising due to increased acidity.

The taking medicine man should be well examined. Doctors do not prescribe drugs of this group to the following patients:

• having increased sensitivity or allergies to the components of the medication;
• women on the whole period of gestation and during lactation;
• children of any age.

Patients with liver and kidney pathologies need to pay special attention and is better to monitor the reaction of their body to use tablets or the introduction of the solution.

Using

The international name of the drug (Famotidin), prescribed in the instructions in Latin, has its own features of the application:

1. before starting use, the full examination is better, since the pharmacy means can give a lubricated clinical picture of many dangerous diseases;
2. it is unacceptable to abruptly cancel the medication - it is necessary to take smaller doses, after which it is at all how to use;
3. unacceptably combine Famotidin with antifungal drugs and antacids, you need to take a break for at least 2 hours;
4. during the treatment period, the diet must be observed;
5. in the pathologies of the liver and kidney, the volume of the prescribed medication should be reduced.

Pills

Quamatel tablets Instructions for use recommends drinking from 1 to 4 times a day. The volume and frequency of Famotidine consumption depends on the severity and nature of pathology. For each patient, it is advisable to choose an individual treatment scheme.

Table of generally accepted tablets use schemes.

Important! The drug is able to influence the speed of psychomotor reactions, so during the reception period it is necessary to be taken care and not exceed the dose-installed dose.

Injection

Quamatel is administered intravenously in exceptional cases, when it is impossible to slow and there is no possibility to take pills. Intramuscular administration is unacceptable. Ampoules is white powder. Before use you need to prepare a solution. For this, sodium chloride is used (up to 10 ml).

It is unacceptable to interfere with a solution of lidocaine, novocaine or other injection fluids. It is preferable to introduce the drug drip, but injections to Vienna are allowed. The solution is introduced slowly, at least 2 minutes. Depending on the severity of the pathology, doctors choose a certain dose of Famotidine:

• 20 mg is once used to prevent Mendelssohn syndrome (no earlier than 2 hours before surgery);
• 20 mg 1-2 times are injected with aggravated manifestations of ulcers (the break should be exactly 8 hours);
• 20 mg with four-time use for the treatment of Zolinger Ellison syndrome.

The injection solution helps in critical situations when emergency intervention is necessary to work in the digestive tract. Subsequently, the patient is transferred to the oral use of the drug.

Important! Injections apply exclusively in medical institutions, injection independently is unacceptable.

Unpleasant reactions

For the quamatel medication, the application should strictly comply with the medical destination. It is impossible to independently adjust the dose of medication or change the reception scheme. It should be remembered that, like any analogue of the quamatel, the claimed tool has a chance to cause side effects:

• vascular disorders - bradycardia, arrhythmia, pressure jumps;
• digestive deviations - a decrease in appetite, abdominal pain, liver pathologies;
• neurological manifestations - apathy, fatigue, drowsiness;
• violations in the work of the hematopoietic system;
• allergic and dermatological side effects;
• fever, muscle pain, hearing impairment.

With the appearance of unpleasant reactions, the patient needs to receive medical care as soon as possible. After elimination of negative effects, a specialist selects suitable analogues and substitutes that will not provoke a similar reaction.

Analogs and generics

There is an analogue of structural and relative in the quamatel. The first is completely replaced by the drug, since they have the same active ingredient. Relative analogues have similar indications for use, but operate on the basis of another active component.

Structural substitutes:

• Famotidine;
• Gastrosidine;
• Famine;
• Ulfamide.

If for some reason the consumer does not suit the quamatel tool, the analog is selected with another active component:

• Ranitidine;
• Zantak;
• Hystak;
• Cimetidine.

Output

At the prescription product quamatel, the side reactions rarely occur, but they are not excluded. In order for the treatment to make the maximum benefit, it is necessary before applying the drug to undergo a survey and get an appointment from a specialist.

Independent use of tablets and injections is dangerous, can lead to unexpected reactions of the body. In the absence of a positive effect, within a few days of using tablets, refer to the gastroenterologist.

Diseases of the gastrointestinal apparatus are often found in our lives. If you do not treat such ailments on time, an ulcer may appear. For the treatment of exacerbation with such diseases, the quamatel preparation is often prescribed. It acts quickly, has a cumulative effect and is inexpensive. Analogs do not always replace it. For example, when using a substitute called "Famotidin", people complain about the appearance of side effects.

Composition of the medicinal product

The drug has two forms of release. This is a lyophilized powder, which is specifically bred to introduce injections, and tablets.

The drug for quamatel injection (20 mg) (instructions for use describes in detail the application scheme of this medication) contains a factor of Famotidin. The auxiliary elements here are:

• acid aspartic acid;
• mannitol;
• sodium chloride;
• purified water.

One tablet contains 40 mg of the active ingredient. Here, additional substances are:

• colloidal silicon dioxide;
• magnesium stearate;
• pisidon K90;
• sodium carboxymethyl starch;
• talc;
• corn starch;
• lactose monohydrate.

Powder for preparing the solution is enclosed in glass ampoules. In the package five ampoules and solvent to them. Tablets have a round shape and pink color. Packed in aluminum blisters. In the cardboard box can be 14 or 28 tablets.

Preparation "Quamatel": Indications for use

The testimony for the use of the medication serves as a ulcer of 12 pans and the stomach, which is in the stages of exacerbation. Prescribed a medicine for symptomatic ulcers and to prevent their education. Used in reflux-esophagite, as well as during the gastrium, the quamatel preparation. The use of the drug gives a good result with gastric and intestinal bleeding, where it is involved in the complex with other medicines. Associate a means of as well as to prevent the gravity of the gastric juice, which is carried out under general anesthesia

Contraindications

It acts quickly and efficiently with the exacerbation of gastrointestinal diseases drug "Quamatel". Application (reviews note that this agent has few contraindications and it is convenient to use it) this medication should be carried out only by appointing a doctor. The medication is not prescribed during pregnancy and during the period of breastfeeding a child. The ban for the use of the medicine is children's age and even hypersensitivity to the components of the quamatelomate. Also, the drug is not used in particular sensitivity to other drugs that are histamine H2 receptor blockers.

With extreme caution, the means is prescribed to patients with hepatic and renal failure, as well as cirrhosis of the hepatic organ, which is accompanied by portoystene encephalopathy, which is a history.

Drug Quamatel: Instructions for use

The ampoules and tablets "Quamatel" should be applied only after consulting with the doctor.

The powder is lyophilized, used for the preparation of an injection solution, is administered:

• intravenously;
• drip;
• inkid

Such a treatment scheme is applied only in severe cases when the patient has the ability to take the drug orally.

This formation form is used only in the hospital. If the patient is possible, they are immediately transferred to the tablets. The average injecting dosage is 20 mg (one ampoule), it is introduced twice a day, that is, every twelve hours. Once it is impossible to introduce more than 20 mg.

In the presence of gastrices begin treatment with a dose of 20 mg, which should be administered to the patient every six hours. With subsequent treatment, the dose adjustment is carried out on which the condition of the patient and the production of hydrochloric acid is affected.

To prevent the aspiration of the stomach before applying a common anesthesia, about 20 mg of medication is introduced into vein. As a rule, this procedure is carried out on the eve of the surgical operation or in two hours and more before it.

Patients with kidney pathology (when the QC falls below the mark of 30 ml / min., And the plasma serum indicator exceeds 3 mg / dl) the daily dosage is reduced to 20 mg. The gap between drug intake is increased to 36-48 hours.

If there are violations in the work of the liver, then quamatel (20 mg) instructions for use advises to apply with extreme caution. The drug in this case is introduced in small doses.

It notes that before injection, a solution with a quamatel medicine, instructions for use should be properly prepared. The powder ampoule is dissolved in 5-10 ml of solvent. The prepared solution at room temperature does not change its properties throughout the day. The medicine is injected slowly, at least two minutes. When the means is introduced drip, the duration of the infusion is 15-30 minutes. In this case, the solution is made directly before the procedure.

In the first handy case, the patient is transferred from injections to tablets.

In the ulcer of the stomach and 12 pans, which is in the aggravation stage, the drug is prescribed in the amount of 40 mg. This amount is used once a day. You can drink a medicine twice a day at 20 mg. If there is a need, the daily dosage is adjusted to 80-160 mg. The duration of the therapeutic course is from four to eight weeks.

To prevent the exacerbation of the ulcers of the gastric organ and the 12 pans of Kvamatel, consumed 20 mg before the departure to sleep.

During the diagnosis of reflux-esophagitis, the tablets drink 20 mg in the morning and in the evening. Treatment is carried out throughout the six weeks. If there is a need, then the dosage increases to 80 mg and divide into two receptions.

In patients with gastric, the initial dose is 20-40 mg. This amount of medication should be taken every six hours. If there is an indication, the daily rate increases to 240-480 mg. The duration of treatment depends on the health status of the patient.

To prevent the selection of gastric content during the period of the total anesthesia, the tablets are used in the amount of 40 mg. The drug can be used on the eve before operating intervention or on the day of the procedure.

Patient and Doctors Reviews

Notes that the doctors are prescribed to prevent the exacerbation of ulcers and gastritis the drug Quamatel, instructions for use. Ampoules (reviews indicate the available price of the drug, about 120 rubles per 14 pieces) are able to remove severe symptoms of the disease, but it is not worth using them for a long time, and when improving it is better to immediately go to the tablets.

Many patients are satisfied with the result that gives medicine. They note that after the first application, the therapeutic effect is noticeable. The pain is stopped, the aggressiveness of the gastric juice is reduced. It passes the sour belching and heartburn. The drug is usually perfectly transferred to patients and rarely causes negative phenomena.

Some people "quamatel" did not help. According to them, pain, heartburn and not only did not pass, but also aggravated. These patients were forced to look for a more suitable medicine. In some cases, the drug caused side effects, such as headache, nausea, diarrhea, confusion of thoughts, appeared difficulty with a concentration of attention. There are patients who have canceled the drug accompanied by negative symptoms, nausea appeared, intestinal disorder.

Preparation "Quamatel" Reviews of doctors got good. It is said that this is an effective remedy for exacerbating the ulcer of the gastric organ and 12-rosewood, as well as gastritis. It is noted that the medicine is suitable for many patients, quickly relieves pain and discomfort in the gastrointestinal tract. It is often prescribed by this medication at elevated acidity of the stomach, heartburn and in the presence of a tendency to form gastritis. This agent is often used in a complex with other medicines.

Analogs of the drug

Despite the proven efficacy of the drug, there are people who did not approach the quamatel. Instructions (Analogues of this medication can always be found in the pharmacy, but only the doctor should select them) recommends that by the appearance of adverse reactions immediately interrupt therapy with this drug and revise treatment. Most often, the quamatel is replaced by the following means:

• "Histak";
• "Gastrosidin";
• "Zantak";
• "Pepsidine";
• "Ulfamid"
• "Atzil";
• "Gusterogen";
• "FAMOPSIN";
• "FAMOAN";
• "Finelael";
• "De Nol".

These and other drugs are a good alternative to the quamatel medicine. Analogs Cheaper than this means can be found in the pharmacy, this is: "Famotidin", "Ranitidine", "Ranisan", "Omez", "Ortanol", "omeprazole". Zvamatel's substitutes on the market are much and so as not to be confused in this manifold of medicines, you should seek advice from the doctor.

• high bioavailability of the drug;
• fast accumulation in the body in the maximum concentration;
• the slowdown half-life of the medicinal product from the body;
• the presence of several forms of drug release: lyophilisate for the preparation of the solution for intravenous administration of 20 mg in the vial in the vial, tablets coated with film sheath of 20 mg and 40 mg.

Disadvantages:

• high price of the drug compared to counterparts.

• Lyophilisate for the preparation of the solution for intravenous administration 20 mg, bottle 72.8 mg with solvent in ampoules and ampulos knife, pack cardboard 5

  387 rub.

• Tablets covered with film shell 40 mg, blister 14, pack cardboard 1

  125 rub.

• Tablets covered with film shell 20 mg, blister 14, tutu cardboard 2

  140 rub.

* The maximum permissible retail cost of drugs calculated in accordance with the Decree of the Government of the Russian Federation No. 865 of October 29, 2010 (for those medicines that are listed)

Instructions for use:

The lyophilisate in the vial is divorced by saline and administered intravenously (during dilution by 10-15 ml of physiological solution) or drip (during dilution by 150-200 ml of saline).

This form of release is prescribed by patients in hospital treatment and is used in Zolinger-Ellison syndrome, bleeding from the upper departments of the gastrointestinal tract, in the active phase of the ulcer of the stomach and / or duodenum.

The drug is prescribed by 20 mg 1-2 times a day depending on the severity of the state. The maximum daily dose of this form of release of the drug should not exceed 80 mg.

Tablets are taken inward, 30 minutes before meals or 1.5-2 hours after meals, drinking a small amount of water 1-2 times a day.

For the treatment of GERD, gastritis and erosive gastroduodenitis, the drug is prescribed at 20-40 mg 1-2 times a day. The maximum daily dose is 120 mg.

For the treatment of peptic ulcer and duodenal ulcer, the drug is assigned to 40 mg 1 time per day at night or 20 mg 2 times a day (in the morning and in the evening). The maximum daily dose of the drug under this disease is 120-140 mg.

For the treatment of Zolinger - Ellison syndrome, the drug is prescribed 40 mg every 5-6 hours (4 times a day). The maximum daily dose of the drug is 240-480 mg.

For the prevention of bleeding from the top department of the gastrointestinal tract, the drug is prescribed by 20 mg 1 time per day at night.

For the treatment of systemic mastocytosis and polyendocrine adenomatosis, the drug is prescribed 80 mg 3 times a day. The maximum daily dose of the drug for these diseases is 480 mg.

For the prevention of Mendelssoh's syndrome, the drug is prescribed at 40 mg per day before the operation or, directly in the morning, on the day of operation.

The duration of treatment is individual and is solved in each particular case by the attending physician.

Patients who suffer from chronic renal failure, with a sharp disruption of the function of the organ, is prescribed with caution in a dose that does not exceed 20 mg 1 time per day.

During pregnancy and breastfeeding, the drug is not prescribed.

Children under 18 Appointment of the drug is prohibited.

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