Essentiale n injection instructions for use. When is Essentiale prescribed in ampoules for intravenous administration? Essentiale side effects
Instructions for use
Clinical and pharmacological group
Hepatoprotector
Release form, composition and packaging
Solution for intravenous administration transparent, yellow color.
Excipients: deoxycholic acid - 126.50 mg, sodium hydroxide - 13.40 mg, benzyl alcohol - 45.00 mg, sodium chloride - 12.00 mg, riboflavin - 0.50 mg, water d / i - up to 5 ml.
5 ml - dark glass ampoules with clamp (5) - contoured packs (1) - cardboard packs.
pharmachologic effect
Overdose
There is no data.
Drug interactions
Until now, not known.
Pregnancy and lactation
The use of the drug with caution during pregnancy, due to the presence of gasoline alcohol in the composition of the drug, which can penetrate the placental barrier (the use of drugs containing benzyl alcohol in newborns born at term or premature newborns was associated with the development of dyspnea syndrome with a fatal outcome) ...
Side effects
In order to assess the frequency of side effects, the following definitions are used: very often (≥1 / 10), often (≥1 / 100 -< 1/10), не часто (≥1/1000 - < 1/100), редко (≥1/10000 - 1/1000), очень редко (< 1/10000), неизвестная частота (по имеющимся данным не возможно установить частоту возникновения).
From the side immune system
In rare cases, due to the content of benzyl alcohol in the preparation, reactions may develop hypersensitivity.
In very rare cases, allergic skin reactions (rash, exanthema or urticaria) are possible.
Unknown frequency: pruritus.
Storage conditions and periods
At a temperature of 2 ° C to 8 ° C. Keep out of the reach of children. List B. Shelf life - 3 years.
Indications
- fatty liver degeneration (including diabetes mellitus);
- acute and chronic hepatitis;
- cirrhosis of the liver;
- necrosis of liver cells;
- hepatic coma and precoma;
- toxic liver damage;
- toxicosis of pregnancy;
- pre- and postoperative treatment, especially during operations in the hepatobiliary zone;
- psoriasis;
- radiation syndrome.
Contraindications
- hypersensitivity to any of the ingredients of the drug;
— childhood up to 3 years.
Carefully
During pregnancy, due to the presence of gasoline alcohol in the composition of the drug, which can penetrate the placental barrier (the use of drugs containing benzyl alcohol in newborns born at term or premature newborns was associated with the development of dyspnea syndrome with a fatal outcome).
special instructions
Use only clear solution!
Instructions for medical use drug
ESSENTIALE® N
Essentiale® N
International non-proprietary name
Solution for intravenous administration 250mg / 5ml
Composition
5 ml of solution contain
active substance - essential phospholipids (phosphatidylcholine from soybeans, dry matter content 93% (3-sn-phosphatidyl) choline) 298.92 mg (250 mg),
excipients: benzyl alcohol, deoxycholic acid, sodium chloride, sodium hydroxide (granules), riboflavin (vitamin B2), water for injection.
Description
Transparent yellow solution, practically free of visible suspended particles.
Pharmacotherapeutic group
Drugs for the treatment of liver diseases.
ATC code A05BA
Pharmacological properties
Pharmacokinetics
Pharmacokinetics of the parenteral form of Essentiale® N was studied by radioactive method. After intravenous administration single dose tritiated essential phospholipids (EPL), mainly containing linoleic acid, the incorporation of radioactivity into the fraction of cephalin, sphingomyelin and lysolecithin was noted. Among the neutral lipid fractions, labeled EPL appears to be more rapidly incorporated into free fatty acids than into cholesterol esters or triglycerides and are delivered to organs, mainly the liver. The uptake of the introduced lecithins by adipose tissue and erythrocytes was not detected. After intravenous administration, the half-life was 60 days. Less than 10% of the labeled substances were excreted in feces, through the kidneys and respiratory organs within 5-7 days after the dose was administered. It is assumed that the remainder of the tritiated essential phospholipids is transformed in the liver for the biosynthesis of HDL (high density cholesterol) or other lipoprotein fractions.
Pharmacodynamics
In liver diseases, the death of hepatocytes occurs, which leads to the release of liver enzymes and an increase in their activity in the blood serum.
The chemical structure of the phospholipids contained in Essentiale® N is similar to that of endogenous phospholipids, however, due to the high content of polyunsaturated (essential) fatty acids in them, the phospholipids in Essentiale® N are more active. The incorporation of high-energy phospholipid molecules into the structure of hepatic cell membranes increases the regeneration of hepatocyte membranes.
Due to the peculiarities of the chemical structure of essential phospholipids, the presence of cis-double bonds (arrangement of hydrocarbon chains on one side of double bonds) bonds in polyunsaturated fatty acids of cell membranes prevents the compaction of the structure of fatty acids. This leads to greater liquefaction of the membrane structure, which is necessary for the optimal functioning of most cells in the body. Through this mechanism, essential phospholipids act on those parts of cells that are receptors for hormones or neurotransmitters, thus increasing the metabolic rate, especially lipids. Phospholipids interfere with impaired lipid metabolism by regulating lipoprotein metabolism so that neutral fats and cholesterol are converted to transportable forms, and most importantly, this occurs by increasing the capacity of uptake of cholesterol by high density lipoprotein and can thus lead to its oxidation. Exogenous phospholipid molecules with their antioxidant properties and the ability to capture free radicals reliably protect lipids from peroxidation, that is, they suppress oxidative stress and reduce cell damage. Essential phospholipids reduce the production of hydrogen peroxide in hepatic microsomes and increase the concentration of reduced glutathione in the liver and plasma.
Intravenous administration of Essentiale® N solution improves the intestinal-hepatic circulation of bile acids in patients with impaired liver function. Phospholipids have a profound effect on the composition and flow of bile. During the excretion of phospholipids by bile, the risk of formation gallstones and the bile composition is stabilized.
Indications for use
As part of complex therapy
fatty degeneration of the liver (steatosis)
acute and chronic hepatitis
alcoholic liver disease
drug damage to the liver
cirrhosis of the liver
hepatic encephalopathy
cholestasis and prevention of recurrence of gallstone formation
pronounced changes functional tests liver with gestosis of pregnant women
Method of administration and dosage
Adults and children from 12 years old injected intravenously slowly, 5-10 ml, in severe cases, 10-20 ml per day. The maximum single dose is 10 ml, the maximum daily dose is 20 ml. The frequency of administration is 1-2 times a day.
Children from 3 to 6 years old2 ml per day, children from 6 to 12 years old, 2-5 ml per day.
The duration of treatment is determined by the doctor taking into account the clinical and laboratory parameters and can range from 5 days to 10 days.
If desired, the solution can be diluted with the patient's blood in a 1: 1 ratio.
It is necessary to avoid mixing Essentiale® N with other drugs in one syringe!
The solution should not be administered intramuscularly, as tissue irritation at the injection site is possible. Do not inject Essentiale® N solution subcutaneously. During the infusion, Essentiale® N is dissolved in 5% glucose solution.
Cannot be diluted in electrolyte solutions (saline sodium chloride solution, Ringer's solution, etc.).
All solutions with Essentiale® N must have a pH of the mixture of at least 7.5, the finished solution must remain transparent during injection.
Side effects
Rarely
Allergic reactions in the form of exanthema or rash, urticaria
Frequency unknown
Contraindications
Hypersensitivity to one of the components of the drug
Children under 3 years old
Newborn and premature babies due to benzyl alcohol
Lactation period
Drug interactions
Possible drug interactions Essentiale® N with anticoagulants. For this reason, the dose of the anticoagulant must be adjusted.
In case of simultaneous administration, the patient should consult a doctor.
special instructions
When using Essentiale® N, there is a potential risk of an allergic reaction to "soybean phospholipids".
The preparation contains trace amounts of ethanol (0.6% by volume), because ethanol used in the process of technological production.
Pregnancy
Intravenous solution of Essentiale® N contains benzyl alcohol, because its penetration into the placenta is possible, the drug should be prescribed with caution during pregnancy.
Features of the effect of the drug on the ability to manage vehicle or potentially dangerous mechanisms
Introduction intravenous solution Essentiale® N does not affect the ability to drive vehicles and work with equipment.
Overdose
At the moment, overdose reactions or symptoms of intoxication in connection with the use of Essentiale N® intravenous solution have not been registered.
Release form and packaging
5 ml of solution in ampoules of yellow neutral glass type I.
5 ampoules in a blister made of polyvinyl chloride film.
1 blister strip, together with instructions for use in the state and Russian languages, are placed in a cardboard box.
In case of group packing, cardboard packs are placed in cardboard boxes and pasted over with tape. A group label is glued to the box.
Storage conditions
Store at temperatures between 2 ° C and 8 ° C.
Keep out of the reach of children!
Storage period
Do not use after the expiration date.
Terms of dispensing from pharmacies
On prescription
Manufacturer
Bulk product manufacturer
Sanofi Aventis S.A., Spain
(Avda. De Leganes n 62, 28925 Alcorcon Madrid, Spain)
Packed
JSC "Khimfarm", Republic of Kazakhstan,
shymkent, st. Rashidova, b / n
Applicant
Sanofi-aventis Kazakhstan LLP, 050016 Republic of Kazakhstan, Almaty, st. Kunaev 21 "B".
The address of the organization that accepts claims from consumers on the quality of products (goods) on the territory of the Republic of Kazakhstan
One ampoule of Essentiale N contains:
Active ingredient: "Essential phospholipids" \u003d EPL® substance 250 mg;
Other ingredients: benzyl alcohol - 45 mg, deoxycholic acid - 115 mg, sodium chloride - 12 mg, sodium hydroxide - 11.500 mg, riboflavin - 0.500 mg, a-tocopherol - 0.750 mg, ethanol - 16.304 mg, water for injection - 4543, 680 mg.
pharmachologic effect"type \u003d" checkbox "\u003e
pharmachologic effect
The drug provides the liver, the structure and metabolic activity of which is disturbed, with a high dose of ready-to-digest, high-energy "essential" phospholipids. "Essential" phospholipids optimally correspond to the chemical structure of human phospholipids. "Essential" phospholipids are incorporated into defective zones (gaps) of cell membranes, restoring their structure and metabolic activity. "Essential" phospholipids:
■ normalize liver function and enzymatic activity of liver cells;
■ reduce the level of energy consumption of the liver;
■ contribute to the regeneration (restoration) of the liver;
■ normalize lipid metabolism (reduce cholesterol and triglycerides, increase high density lipoproteins);
■ stabilize physical- chemical properties bile, help to reduce the lithogenic index.
Indications for use
ESSENTIALE N is a preparation made from raw materials vegetable originused to treat liver disease.
It is used in patients with the various liver disorders listed below to relieve symptoms such as loss of appetite and / or a feeling of heaviness in the right hypochondrium, which may indicate the following liver damage and / or disease:
Fatty liver degeneration (also in diabetes);
Hepatitis of any nature, acute and chronic;
Cirrhosis;
Toxic liver damage, including alcoholic liver disease, drug liver damage;
Cholestasis.
Contraindications
Since this solution contains benzyl alcohol, it should not be used to treat newborns and premature babies. Due to the lack of extensive clinical data on the use of the drug in children, it is contraindicated in children under 12 years of age. In case of hypersensitivity to any ingredient, the drug should not be used.
Method of administration and dosage
Children over 12 years old and adults, in the absence of other doctor's recommendations, slowly inject 1-2 ampoules intravenously, in severe cases - 2-4 ampoules per day. The contents of the two ampoules can be administered simultaneously. Avoid mixed injections. It is recommended to supplement the parenteral administration with oral administration of the drug as soon as possible. In the absence of other doctor's recommendations, the initial dose is 3 times a day, 2 capsules, the maintenance dose is 3 times a day, one capsule. Take the capsules with food, without chewing, with a little water. The duration of treatment depends on the course of the disease.
Side effect"type \u003d" checkbox "\u003e
Side effect
Very rarely, allergic reactions such as exanthema or rashes and hives can occur. Itching (frequency unknown).
Overdose
To date, there have been no reports of reactions associated with an overdose or symptoms of intoxication when using Essentiale N.
Interaction with other medicinal products
Until now, unknown. Pay attention to incompatibility with infusions.
(essential phospholipids | essential phospholipids)
INSTRUCTION
on the medical use of the drug
Registration number:
P No. 016326/01 dated July 11, 2005.Tradename: Essentiale N
Dosage form:
solution for intravenous administration.Composition:
5 ml of solution contains:
Active Ingredient: phosphatidylcholine from soybeans, dried substance, containing 93% (3-sn-phosphatidyl) choline: synonyms - "essential phospholipids", "EPL®" - 250 mg.
Other Ingredients: benzyl alcohol - 45 mg, deoxycholic acid - 115 mg, sodium chloride - 12 mg, sodium hydroxide - 11.5 mg, riboflavin - 0.5 mg, α - tocopherol - 0.75 mg, ethanol - 16.304 mg, water for injection - 4543, 680 mg.
Description:
Transparent yellow solution.
Pharmacotherapeutic group
Hepatoprotective agent. ATX code: A05C.
Pharmacological properties
The drug provides the liver, whose metabolic activity is disturbed, with a high dose of ready-to-digest, high-energy "essential phospholipids". These "essential phospholipids" are ideally combined with naturally occurring endogenous phospholipids in chemical structure. They mainly penetrate the liver cells, invading their membranes.
"Essential phospholipids":
- normalize liver function and enzymatic activity of liver cells;
- reduce the level of energy consumption of the liver;
- promote the regeneration of liver cells;
- convert neutral fats and cholesterol into forms that facilitate their metabolism;
- stabilize the physical and chemical properties of bile.
Indications for use
Fatty degeneration of the liver (including diabetes mellitus); acute and chronic hepatitis, liver cirrhosis, liver cell necrosis, hepatic coma and precoma, toxic liver damage; toxicosis of pregnancy; pre- and postoperative treatment, especially during operations in the area of \u200b\u200bthe hepatobiliary zone; psoriasis; radiation syndrome.
Contraindications
In case of hypersensitivity to any ingredient, the drug should not be used.
Since this solution contains benzyl alcohol, it should not be used to treat children under 3 years of age.
Method of administration and dosage
In the absence of other doctor's recommendations, slowly intravenously inject 1-2 ampoules (5-10 ml) or in severe cases 2-4 (10-20 ml) ampoules per day. The contents of the two ampoules can be administered simultaneously. Do not mix with other medicines in the same syringe.
It is recommended to supplement the parenteral administration with oral administration of the drug as soon as possible.
Side effect
Very rare when administered higher doses Essentiale N can cause gastrointestinal upset (diarrhea).
Interaction with other medicinal products
Until now, not known.
special instructions
Use only clear solution!
Release form
5 ml of the drug in dark glass ampoules with a clamp. 5 ampoules in a PVC strip packaging. 1 contour package together with instructions for use in a cardboard box.
Storage conditions
At temperatures from + 2 ° C to + 8 ° C, out of the reach of children.
Shelf life
3 years. After the expiration date, the drug cannot be used.
Terms of dispensing from pharmacies
On prescription. List B.
Produced
"AND. Nuttermann and See. GmbH ", Germany
Manufacturer's address: Nuttermannalee 1, D-50829, Cologne, Germany
Consumer claims should be sent to the address of the company's representative office in Russia:
101000, Moscow, Ulansky lane, 5.
The liver is one of the main organs human body... She is responsible for synthesis essential substances, converts some substances into others, participates in metabolic processes and serves as a filter, cleansing systems from harmful toxic components.
Therefore, dysfunction of the liver has negative consequences not only directly for this organ, but also for the whole organism. Moreover, any diseases and pathologies are necessarily reflected in the state of the liver. All kinds of medicines that have to be taken to get rid of diseases also deal a significant blow to her.
How to protect the liver?
One of the options for maintaining the liver and restoring its functions after a series of injuries is Essentiale. Today it is included in the list of the most demanded hepatoprotectors with a fairly wide range use.
One of the forms of Essentiale is a solution for intravenous administration in ampoules.
General information about the drug
Any form of Essentiale contains phospholipids (substances necessary for the formation and proper functioning of the cell membrane). Phospholipids are substances that are not synthesized in the body and are obtained exclusively from the outside. Moreover, they are important for the body no less than amino acids.
Essentiale uses natural phospholipids derived from soybeans. The high content of polyunsaturated fatty acids in soy makes the phospholipids isolated from it especially useful. Once in the human body with the drug, they contribute to the restoration of receptor connections in liver cells, "triggering" their renewal.
Also, phospholipids:
- They inhibit the formation of connective tissues in the hepatic ducts.
- Reduce the risk of sand and stone formation in gallbladder.
- They improve the work of enzymes of the cell membrane, which are responsible for transporting some substances into the cell, and removing others outside of it.
- Promote the improvement of protein and lipid metabolism.
- They accumulate glycogen (the main form of glucose storage) in the liver.
- Convert cholesterol and other fats that cause arterial disease into more harmless and beneficial forms.
- Helps reduce the amount of energy the liver needs to function properly.
- Reduces or prevents the accumulation of fat in the cells of the organ.
- Reduces the risk of cirrhosis and many other pathological changes in the liver.
Due to such a varied and all-round effect of the drug on the body, its intake increases the liver's resistance to negative influences, allows it to quickly neutralize harmful substances entering the body.
Benefits
In addition, Essentiale is able to positively influence other vital important organs and systems of the human body. Additional effects of the drug include:
- normalization metabolic processes in organism;
- reducing the number of atherosclerotic plaques in the vessels and reducing their size;
- improvement clinical picture in case of illness diabetes mellitus (its manifestations become less pronounced);
- improved blood quality (becomes less dense).
Important. All this allows Essentiale to be included in complex therapy at various diseases.
As for the difference different forms, then when the drug is injected, it has a stronger and faster effect on the body. Therefore, this version of the drug is prescribed for the treatment of acute and advanced stages of disease.
In addition to differences in the forms of administration, medicines also differ in their composition. So, Essentiale H contains only phospholipids. Essentiale is additionally enriched with B vitamins and nicotinamide, which enhance the effect of the main component.
Indications for use
Considering the effect of Essentiale, injections are prescribed for:
- Sharp and chronic hepatitis, regardless of their origin.
- Fatty hepatic dystrophy, which appeared due to various reasons.
- Pathology arising from disturbances in the blood circulation of the hepatic vessels and function bile ducts (cirrhosis).
- Necrotic processes in cells.
- Liver failure.
- Hepatic precoma and coma.
- Hyperlipoproteinemia.
- Hypertriglyceridemia.
- Disorders in the liver, resulting from the development of various diseases.
- Toxicosis.
- Increased activity of the enzymes AsAT and ALAT in pregnant women.
- Prophylaxis to prevent recurrence of gallstones.
- Cholestasis (a decrease in the flow of bile into duodenum due to violations in the processes of bile formation and excretion).
- Psoriasis.
In addition, Essentiale is included in preoperative therapy. Most often, the drug is prescribed before operations on the liver, gallbladder and bile ducts.
Important. Its reception is also included in the complex of therapeutic measures for postoperative recovery.
In addition to direct indications for the use of Essentiale, there are some other diseases in which injections are used as an additional therapy. Among them:
- various types of disorders in the work of the cardiovascular system;
- malfunctions of organs digestive system;
- skin diseases;
- oncological diseases.
Also, the drug is prescribed for prophylactic purposes to prevent premature aging, reduce intoxication of the body due to alcohol and various chemical poisoning.
Contraindications
Despite all positive characteristics drug, the use of injections (as well as other forms) Essentiale is contraindicated in case of increased sensitivity of the patient to at least one of the components that make up its composition.
According to the instructions, it is strictly forbidden to give injections to newborns and children born ahead of time, since benzyl alcohol (excipient) contained in Essentiale can cause the development of Gasping syndrome in a child. The latter is a lethal breathing disorder with suffocation.
Important. The restrictions on use apply to children under 3 years of age.
For the same reason, the medicine should not be taken by nursing mothers. In addition, Essentiale should be taken with increased caution for people prone to manifestation allergic reactionsespecially for those who have previously been allergic to soy foods.
If signs of allergy appear while taking the drug, you must refuse it and immediately consult a doctor.
Side effects
When correct application Essentiale injection solution is well tolerated by the body without causing side effects.
However, in some cases (for example, as a result of an overdose of the drug), its intake is accompanied by:
- disorders of the digestive system (for example, diarrhea);
- redness skin at the injection site.
You should definitely notify your doctor about the appearance of such symptoms.
Applications and dosage
Essentiale and Essentiale N - are solutions intended for intravenous administration. Each ampoule contains 250 mg of phospholipids + auxiliary components.
Instructions for use Essentiale determines the optimal dose for patients over the age of 12 years in the amount of 5-10 ml per day. In severe forms of the disease, the daily dose is increased to 20 ml.
As a rule, the daily dose of the drug is divided into two doses (inject up to 10 ml at a time). However, both the dosage and the daily number of injections vary, depending on the condition and characteristics of the patient's body.
The entire course of treatment takes 10 to 30 days. Subsequently, doctors recommend replacing the injections with an encapsulated drug.
Taking the drug for psoriasis
In psoriasis and some other diseases of the external skin, treatment begins with the intake of Essentiale forte N capsules. The daily dose of the drug should be 1.8 g. The general course of administration is up to 14 days.
After that, the patient is prescribed injections with Essentiale. Injections are made once a day, 1 ampoule. A total of 10 injections should be made, after which they return to oral intake, and drink it for 2 months.
Use in Infectology
Standard dosage injections are often used in the treatment of many intestinal infections... Taking the drug helps not only to cleanse the body from toxins as soon as possible, but also gives additional protection to the liver from the effects of medications.
Most often, Essentiale solution is used in conjunction with other drugs for cholera, shigellosis, brucellosis, botulism, etc.
With oncology
It is prescribed for paraneoplastic syndrome. This syndrome is characterized by the formation of a tumor that produces toxins and biologically active substances... In this case, Essentiale also protects the liver from exposure to toxic substances.
Included in comprehensive supportive therapy, the solution helps to reduce damage internal organs, normalizes the amount of bilirubin in the blood and stabilizes the patient's condition.
As a rule, in this case, Essentiale is used in preparation for surgical intervention or with chemotherapy.
With Guillain-Barré syndrome
Due to the large accumulation of toxic substances released during acute demyelinization, the functionality of the cells of the hepatic parenchyma is disrupted, which causes serious pathologies in the liver.
To avoid such a situation, Essentiale injections are prescribed. By creating reliable protection for the liver, the drug simultaneously minimizes damage to other organs and systems of the body. Correctly prescribed therapy avoids the most serious consequence of the disease - damage to the peripheral nervous system.
In endocrinology
Intravenous drug is widely and successfully used in the treatment of a number of autoimmune diseases... This allows you to avoid complications and increase the effect of the therapy.
In nephrology
A good effect is given by the use of Essentiale in the treatment renal failure any form (chronic or acute). It is known that in case of impaired renal function, an even greater burden falls on the liver to cleanse the body of harmful substances. Supportive therapy in the form of hepatoprotective injections not only reduces the level of toxins, but also improves the prognosis for the patient. Similarly acts medicine and with pyelonephritis, as a result of which many enzymes and compounds formed during suppuration enter the bloodstream.
In pediatrics
In pediatrics, Essentiale solution is often used as an adjunct therapy for various diseases that give complications to the liver or threaten to severe intoxication of the body.
Starting from the age of 12, with a body weight of 43 kg, the drug is administered to children in normal dosages. For children 3-6 years old, the daily dose is calculated so that the daily intake does not exceed 2 ml. The drug is administered once. Children over 6, but under 12 years of age, are administered up to 5 ml of the drug per day.
In very rare cases, Essentiale is prescribed to children under the age of 1 year. Such exceptions are made in milder forms hemolytic disease in a child, with strong infectious diseases - to protect the liver, prevent complications and reduce the damage from drug use.
In obstetrics
First of all, during pregnancy Essentiale helps to cope with attacks of toxicosis.
Also, the remedy can provide irreplaceable help in gestosis, in which the functions of blood vessels, kidneys and even the brain are seriously impaired, which negatively affects the development of the fetus.
Essentiale helps to weaken an unpleasant condition, reduces the amount of antibodies in the body due to the conflict between the Rh factors of the mother and the fetus, in parallel contributing to the correct assimilation of all by the child essential micronutrients and valuable substances.
Also, the use of the drug reduces the risk of complications during pregnancy in women who have previously had jaundice or have liver problems.
In surgery and radiology
The drug brings significant benefits when surgical methods treatment. It is prescribed, for example, after removal of the gallbladder or after partial liver transplantation. Reception of Essentiale after organ transplant allows accelerating tissue regeneration and significantly reduces the risk of rejection of the transplanted organ.
In radiology it is used as one of the means for the treatment of radiation sickness. The solution increases the body's resistance to radiation and relieves and diminishes symptoms.
For the beauty and health of hair
Besides traditional methods application, Essentiale solution is used and not quite standard. One option is to use it to strengthen hair.
- To strengthen the hair follicles, it is necessary to make a mask from the preparation added to a mixture of egg yolks with sour cream (or kefir).
- For a mask for short hair, it is enough to use a third of the solution from one ampoule. On long hair - half an ampoule.
- The preparation of the healing strengthening composition is very simple: having collected the solution with a syringe, it is mixed with the rest of the ingredients (1 yolk and 1-2 tsp / l sour cream or kefir).
- Apply the mixture to washed and slightly dried hair. Keep the mask on your hair for an hour. After that, it is washed off with water without shampoo.
The frequency of the procedure is once a week. The course is 5 weeks. Subsequently, the mask can be applied for prophylaxis once a month.
Important. Dimexide will help to enhance the effect of the strengthening mixture.
Rules for using Essentiale solution
For the drug to bring maximum benefit, it must be used correctly. To do this, you should adhere to some rules:
- Inject only with clear solution. If, during mixing or during the introduction, the slightest signs of turbidity appear in it, then the procedure must be interrupted, discard the container with the cloudy contents. The rest of the dose of the drug must be administered from another ampoule.
- Essentiale and other drugs cannot be combined in one syringe.
- No normal saline solution is used to dilute the drug. It should be diluted with the patient's own blood in a 1: 1 ratio. Instead of blood, it is allowed to use electrolyte-free solutions (5% xylitol, 5 or 10% glucose). An exception is made only when blood cannot be used.
- The drug is administered exclusively intravenously. It cannot be used intramuscularly. Also, you can not make subcutaneous injections, since there is a high probability of irritation at the injection site.
- The medicine is administered very slowly.
- If the patient is prescribed a large number of injections, then the injections are replaced with droppers.
