Trade name:

Medical antiseptic solution

International non-proprietary or group name:

Dosage form:

concentrate for solution preparation for external use

Composition:

Active substance:
ethanol (ethyl alcohol) 95% - 100.0 ml.

Description:

transparent colorless mobile liquid with a characteristic alcoholic odor.

Pharmacotherapeutic group:

antiseptic

ATX code:

Pharmacological properties

Pharmacodynamics
Antimicrobial agent, when applied externally, has an antiseptic effect (denatures proteins of microorganisms). Active against gram-positive and gram-negative bacteria and viruses. Antiseptic activity increases with an increase in ethanol concentration.
To disinfect the skin, a 70% solution is used, which penetrates into the deeper layers of the epidermis better than a 95% solution, which has a tanning effect on the skin and mucous membranes.
Pharmacokinetics
When applied externally, it is absorbed from the surface of the skin and mucous membranes into the systemic circulation. It is metabolized in the liver with the participation of the isoenzyme CYP2E1, of which it is an inducer.

Indications for use

It is used as an antiseptic and disinfectant in the treatment of the initial stages of diseases (boil, felon, mastitis); when processing the hands of a surgeon (methods of Fürbringer, Alfred), an operating field (including in persons with increased sensitivity to other antiseptics, in children and during operations on areas with thin skin in adults - neck, face).

Contraindications

Hypersensitivity.

Carefully

Pregnancy, period breastfeeding, childhood.

Application during pregnancy and during breastfeeding

Special studies of the use of the drug during pregnancy and during breastfeeding have not been conducted. During pregnancy and during breastfeeding, it is used only if the intended benefit to the mother outweighs the potential risk to the fetus and child.

Method of administration and dosage

Outwardly, in the form of lotions, compresses, rubdowns.
For treatment of the operating field and preoperative disinfection of the surgeon's hands, a 70% solution is used, for compresses and rubdowns (to avoid burns), it is recommended to use a 40% solution.
A 95% solution should be diluted to the required concentrations and used as indicated.

Side effect

Allergic reactions, skin burns, flushing and soreness of the skin at the site of application of the compress.
When applied externally, it is partially absorbed through the skin and can have a resorptive general toxic effect (depression of the central nervous system).

Overdose

It causes a characteristic alcoholic excitement, in large doses inhibits the functions of the central nervous system.

Interaction with other medicinal products

When used simultaneously with preparations for external use that contain organic compounds, it can cause denaturation of protein components.

special instructions

When applied externally, ethanol is partially absorbed through the skin and mucous membranes, which must be taken into account when using it in children, pregnant women and during lactation.
Do not use near open flames.

Influence on the ability to drive vehicles, mechanisms

The drug used as a solution for external use does not affect the ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions. When long-term use in large doses, the drug may be absorbed into the systemic circulation, which must be taken into account when driving transport, mechanisms. Release form

Concentrate for preparation of solution for external use 95%.
100 ml in orange glass vials, sealed with perforated aluminum caps. A self-adhesive label is attached to each bottle. Each bottle, along with instructions for use, is placed in a cardboard box.
40 vials with an equal number of instructions for use are placed in a corrugated cardboard box (for hospitals).
5.0, 10.0 and 21.5 liters in polyethylene cans made of low pressure polyethylene. Each canister is supplied with instructions for use (for hospitals).

Shelf life

5 years. Do not use after the expiration date.

Storage conditions

At a temperature not exceeding 25 ° С, in a well-sealed container, away from fire.
Keep out of the reach of children.

Vacation conditions

Dispensed by prescription.

Marketing Authorization Holder / Consumer Claims Organization

Alliance LLC, 192019, St. Petersburg, st. 2nd Ray, 13, pom. thirteen

Manufacturer

LLC "Armavir Interdistrict Pharmacy Base".

Production locations:
1) 352900, Krasnodar region, Armavir, st. Tunnel, d. 24
2) 174360, Novgorod region, Okulovsky municipal district, urban settlement Uglovskoe, der. Berezovka, bldg. 75 A.

28.02.2012 3690

Ethanol. Description, instruction.

Treatment of the initial stages of diseases: boil, felon, mastitis; treatment of the surgeon's hands (Fürbringer, Alfred's methods), the operating field (including in persons with hypersensitivity to other antiseptics ...

International name:
Ethanol (Ethanol)

Description active substance (INN):
Ethanol

Dosage form:
solution for external use [alcohol], solution for external use and preparation dosage forms

pharmachologic effect:
Antimicrobial agent, with topical application has an antiseptic effect (denatures proteins of microorganisms). Active against gram-positive and gram-negative bacteria and viruses. Antiseptic activity increases with an increase in ethanol concentration. For skin disinfection, a 70% solution is used, which penetrates into the deeper layers of the epidermis better than 95%, which has a tanning effect on the skin and mucous membranes. When administered systemically, it has the ability to induce analgesia and general anesthesia. It is a solvent for a number of drugs, as well as an extractant for a number of substances contained in medicinal plant materials.

Indications:
Treatment of the initial stages of diseases: boil, felon, mastitis; treatment of the surgeon's hands (Fürbringer, Alfred's methods), the surgical field (including in persons with hypersensitivity to other antiseptics, in children and during operations on areas with thin skin in adults - neck, face). Preservation of biological material, production of dosage forms for external use, tinctures, extracts. As a local irritant drug.

Contraindications:
Hypersensitivity.

Side effects:
Allergic reactions, skin burns, flushing and soreness of the skin at the site of application of the compress. When applied externally, it is partially absorbed through the skin and mucous membranes and can have a resorptive general toxic effect (depression of the central nervous system).

Method of administration and dosage:
Outwardly, in the form of lotions. For treatment of the operating field and preoperative disinfection of the surgeon's hands, a 70% solution is used, for compresses and rubdowns (to avoid burns), it is recommended to use a 40% solution. A 95% solution should be diluted to the required concentrations and used as indicated. As an irritating drug - in the form of rubdowns and compresses. Inside apply in accordance with the instructions for medical use dosage forms prepared on the basis of ethanol.

Special instructions:
When used externally, ethanol is partially absorbed through the skin and mucous membranes, which must be taken into account when using it in children.

pharmachologic effect

Antiseptic. When applied externally, it has an antimicrobial effect. Active against gram-positive and gram-negative bacteria and viruses. Denatures proteins of microorganisms.

Antiseptic activity increases with an increase in ethanol concentration.

For skin disinfection, a 70% solution is used, which penetrates into the deeper layers of the epidermis better than 95%, which has a tanning effect on the skin and mucous membranes.

When used systemically, it has the ability to induce analgesia and general anesthesia. The most sensitive to ethanol are the cells of the central nervous system, especially the cells of the cerebral cortex, acting on which, ethanol causes a characteristic alcoholic arousal associated with a weakening of inhibition processes. Then there is also a weakening of excitation processes in the cortex, suppression of the spinal cord and medulla oblongata with suppression of the activity of the respiratory center.

Is a solvent for a number of medicines, as well as an extractant for a number of substances contained in medicinal plant materials.

Pharmacokinetics

Ethanol is metabolized in the liver with the participation of the isoenzyme CYP2E1, of which it is an inducer.

Indications

Treatment of inflammatory skin diseases in initial stage (boil, felon, mastitis); treatment of the surgeon's hands (Fürbringer, Alfred's methods), the operating field (including in persons with hypersensitivity to other antiseptics, in children and during operations on areas with thin skin in adults - in the neck, face).

As a local irritating drug.

For the manufacture of dosage forms for external use, tinctures, extracts.

Conservation of biological material.

Dosage regimen

It is used depending on the indications and dosage form.

Side effect

Allergic reactions, skin burns, flushing and soreness of the skin at the site of application of the compress. When applied externally, it is partially absorbed through the skin and mucous membranes and can have a systemic toxic effect (depression of the central nervous system).

Contraindications for use

Hypersensitivity to ethanol.

Application during pregnancy and lactation

Application during pregnancy and lactation is allowed if the benefit to the mother outweighs the potential risk to the fetus and child.

Application in children

Overdose

No data available.

Drug interactions

With simultaneous use, it enhances the effect of drugs that have a depressing effect on the central nervous system, cardiovascular system, respiratory center.

When taken orally with drugs that have an inhibitory effect on the enzyme aldehyde dehydrogenase (which is involved in the metabolism of ethyl alcohol), the concentration of the ethanol metabolite, acetaldehyde, increases, which causes flushing, nausea, vomiting, general malaise, tachycardia, and a decrease in blood pressure.

Terms of dispensing from pharmacies

On prescription.

Storage conditions and periods

In a well-sealed container, away from wholesale sources, at a temperature not exceeding 25 ° C. Keep out of the reach of children. Shelf life is 2 years.

special instructions

Should not be taken orally during drug treatment.

When applied externally, ethanol is partially absorbed through the skin and mucous membranes, which should be taken into account when used in children.