Cefekon 250 candles for children. Tsefekon d - instructions for use
in a contour acheikova packing 5 pcs .; in a pack of cardboard 2 packages.
Description of the dosage form
Suppositories of white or white color with a creamy or yellowish tint, torpedo-shaped.
Pharmacodynamics
Paracetamol has analgesic and antipyretic effects. Blocks cyclooxygenase in the central nervous system, affecting the centers of pain and thermoregulation. In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on cyclooxygenase, which explains the absence of a significant anti-inflammatory effect.
The drug has no negative effect on water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa.
Pharmacokinetics
Absorption is high, rapidly absorbed from the gastrointestinal tract. The period of reaching C max is 30–60 minutes, binding to plasma proteins is 15%. Penetrates the BBB. The volume of distribution and bioavailability in children and newborns are similar to those in adults.
Metabolized in the liver: 80% - enters into conjugation reactions with glucuronic acid and sulfates to form inactive metabolites; 17% - undergoes hydroxylation with the formation of active metabolites, which are conjugated with glutathione and form inactive metabolites. With a lack of glutathione, these metabolites can block the enzyme systems of hepatocytes and cause their necrosis. In newborns of the first two days of life and in children 3–10 years old, the main metabolite of paracetamol is paracetamol sulfate, in children 12 years of age and older - conjugated glucuronide.
T 1/2 - 2-3 hours. Within 24 hours 85-88% of paracetamol is excreted by the kidneys in the form of glucuronides and sulfates, unchanged - 3%. There is no significant age-related difference in the rate of elimination of paracetamol and in the total amount of the drug excreted in the urine.
Cefekon D: Indications
Used in children from 3 months to 12 years old as:
antipyretic agent for acute respiratory infections, influenza, childhood infections, post-vaccination reactions and other conditions accompanied by an increase in body temperature;
pain reliever for pain syndrome of mild and moderate intensity, incl. head and toothache, muscle pain, neuralgia, pain in trauma and burns.
In children from 1 to 3 months, a single dose of the drug is possible to lower the temperature after vaccination.
Cefekon D: Contraindications
hypersensitivity to the components of the drug;
age up to 1 month of life.
Carefully:
impaired liver and kidney function;
gilbert's syndrome; Dubin-Johnson and Rotor;
diseases of the blood system (anemia, thrombocytopenia, leukopenia);
genetic absence of the enzyme glucose-6-phosphate dehydrogenase.
Method of administration and dosage
Rectally, after a cleansing enema or spontaneous bowel movement. The dosage of the drug is calculated depending on age and body weight, in accordance with the table. A single dose is 10-15 mg / kg 2-3 times a day after 4-6 hours. The maximum daily dose of paracetamol should not exceed 60 mg / kg.
Dosage of the drug for children of different ages
Cefekon D: Side effects
From the digestive tract: nausea, vomiting, abdominal pain.
Allergic reactions: itching, rash on the skin and mucous membranes, urticaria, Quincke's edema.
From the side of the hematopoietic organs: anemia, leukopenia, agranulocytosis, thrombocytopenia.
When long-term use in large doses - hepatotoxic and nephrotoxic effects (interstitial nephritis, papillary necrosis), hemolytic anemia.
Suppositories of white or white color with a yellowish or creamy shade, torpedo-shaped.
Active ingredients
Release form
Suppositories
Composition
One suppository contains: active substance - paracetamol - 50 mg, 100 mg or 250 mg, suppository bases: solid fat (witepsol, suppository) - until a suppository weighing 1.25 g is obtained.
Pharmacological effect
Anti-inflammatory, antipyretic, pain reliever
Pharmacokinetics
Absorption is high, rapidly absorbed from the gastrointestinal tract. The period for reaching the maximum concentration is 30-60 minutes. Penetrates the blood-brain barrier. The magnitude of bioavailability in children and newborns is similar to those in adults. Metabolized in the liver. The half-life is 2-3 hours. Within 24 hours, 85-95% of paracetamol is excreted by the kidneys in the form of glucuronides and sulfates, unchanged - 3%. There is no significant age-related difference in the rate of elimination of paracetamol and in the total amount of the drug excreted in the urine.
Indications
Used in children from 3 months to 12 years as: an antipyretic agent for acute respiratory diseases, influenza, childhood infections, post-vaccination reactions and other conditions accompanied by an increase in body temperature, a pain reliever for pain syndrome of mild and moderate intensity, including : headache and toothache, muscle pain, neuralgia, pain in trauma and burns. In children from 1 to 3 months, a single dose of the drug is possible to lower the temperature after vaccination, the use of the drug for all indications is possible only as directed by a doctor.
Contraindications
Hypersensitivity, neonatal period (up to 1 month).
Precautions
Renal and hepatic failure, benign hyperbilirubinemia (including Zhilber's syndrome), viral hepatitis, alcoholic liver damage, alcoholism, pregnancy, lactation, genetic absence of glucose-6-phosphate dehydrogenase, concomitant use of other paracetamol-containing drugs.
Method of administration and dosage
Rectally, after a cleansing enema or spontaneous bowel movement. The dosage of the drug is calculated depending on age and body weight, in accordance with the table. A single dose is 10-15 mg / kg 2-3 times a day after 4-6 hours. The maximum daily dose of paracetamol should not exceed 60 mg / kg.
Side effects
Allergic reactions (including skin rash).
Overdose
Symptoms: during the first 24 hours after administration - pallor skin, nausea, vomiting, anorexia, abdominal pain, impaired glucose metabolism, metabolic acidosis. Symptoms of liver dysfunction may appear 12-48 hours after an overdose. In case of severe overdose - liver failure with progressive encephalopathy, coma, death, acute renal failure with tubular necrosis (including in the absence of severe liver damage), arrhythmia, pancreatitis. The hepatotoxic effect in adults is manifested when taking 10 g or more. Treatment: the introduction of donors of SH-groups and precursors of the synthesis of glutathione - methionine 8-9 hours after overdose and N-acetylcysteine \u200b\u200b- 12 hours later. The need for further therapeutic measures (further administration of methionine, intravenous administration N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after taking it.
Interaction with other drugs
Stimulants of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic medicines increase the production of hydroxylated active metabolites, which makes it possible for the development of severe intoxications, even with a small overdose. Microsomal oxidation inhibitors (including cimetidine) reduce the risk of hepatotoxic effects. When taken together with salicylates, the nephrotoxic effect of paracetamol increases. The combination with chloramphenicol leads to an increase in the toxic properties of the latter. Enhances the effect of anticoagulants indirect action, reduces the effectiveness of uricosuric drugs.
special instructions
If the fever continues for more than 3 days and the pain syndrome continues for more than 5 days, you should consult your doctor. Avoid the simultaneous use of paracetamol with other paracetamol-containing drugs, as this can cause an overdose of paracetamol. When using the drug for more than 5-7 days, the peripheral blood parameters should be monitored and functional state liver. Paracetamol distorts performance laboratory research in the quantitative determination of glucose and uric acid in plasma.
Storage conditions
Out of the reach of children, at a temperature not exceeding 20 ° C.
Composition
One suppository contains
active substance: paracetamol - 50 mg or 100 mg or 250 mg.
Basis for suppositories: solid fat - sufficient amount to obtain a suppository weighing 1.25 g.
Pharmacotherapeutic group
ATX code:. Other analgesic and antipyretic drugs. Aniline derivatives.
Description
Suppositories of torpedo-shaped white or white with a yellowish or brownish shade.
Pharmacodynamics
Paracetamol has analgesic, antipyretic and mild anti-inflammatory effects. The mechanism of action is associated with inhibition of prostaglandin synthesis and the effect on the center of thermoregulation in the hypothalamus.
Pharmacokinetics
Absorption of paracetamol with rectal administration is slower than with oral administration, however more complete. The maximum concentration in blood plasma is reached 2-3 hours after administration.
Paracetamol is rapidly distributed in all tissues of the body. Concentrations in blood, saliva and plasma are comparable to each other. Plasma protein binding is weak.
Paracetamol is metabolized in the liver to form inactive compounds with glucuronic acid and sulfates.
A small part of paracetamol is metabolized by cytochrome P450 to form an active intermediate metabolite (N-acetylbenzoquinone imine), which under normal conditions is quickly rendered harmless by reduced glutathione and excreted in the urine after binding with cysteine \u200b\u200band mercapturic acid. However, with a massive overdose, the amount of this toxic metabolite increases.
Paracetamol is excreted mainly in the urine; 90% of the dose taken is excreted by the kidneys within 24 hours, mainly in the form of glucuronide (60-80%) and sulfate (20-30%); less than 5% is excreted unchanged.
The half-life is from 4 to 5 hours.
With severe renal failure (creatinine clearance below 10 ml / min), the excretion of paracetamol and its metabolites slows down.
Indications for use
Symptomatic treatment pain from mild to moderate intensity and / or febrile conditions.
Method of administration and dosage
Rectally. It is advisable that before using Cefekon® D suppositories, the child goes to the toilet or receives a cleansing enema. Lay the baby on its side. Free the suppository from the blister strip packaging. Insert the suppository carefully into the child's anus with the pointed end. After that, the child should not get up for 1-2 minutes.
Only whole suppositories should be administered. Do not break suppositories before use. Do not use more suppositories than indicated in the instructions.
Suppositories are not intended to be divided in order to obtain the required dosage. In case of diarrhea, the administration of a suppository is not recommended.
The dosage of the drug is calculated depending on age and body weight, in accordance with the table. The approximate age of children based on body weight is given as a guideline only. A single dose is 10-15 mg / kg of the child's body weight. If necessary, this dose can be re-administered, but no more than 4 times in 24 hours. The interval between each dose should be at least 4 hours.
Do not exceed the recommended dose. Higher doses do not increase the analgesic effect. The maximum daily dose of paracetamol (including with the simultaneous use of other paracetamol-containing drugs) should not exceed 60 mg / kg of the child's body weight.
If, when calculating the daily dose in accordance with the child's body weight, a single dosage is required less than the contents of one suppository, then after consulting a doctor, it is recommended to use others dosage forms paracetamol (for example, oral solution or suspension). When treating children, the dose calculation mode should be followed in accordance with the child's body weight, and depending on this, the appropriate dosage form must be selected.
The drug should be used under medical supervision, with extreme caution in children under 1 year of age. In children from 1 to 3 months (weighing at least 4 kg), a single use of the drug is possible to lower the temperature after vaccination. The use of the drug is possible only as directed by a doctor
In the case of severe renal failure (creatinine clearance below 10 ml / min; the interval between the use of suppositories should be at least 8 hours.
The duration of the course of treatment is 3 days. Prolongation of the course, if necessary, after consulting a doctor.
Side deysyour
Side effects in therapeutic doses are very rare.
From the respiratory system:
Rarely ( From the gastrointestinal tract: often (from ≥ 1/100 to From the immune system: rarely (from ≥ 1/10000 to On the part of the skin and subcutaneous tissues: rarely (from ≥ 1/10000 to From the liver and biliary tract: rarely (from ≥ 1/10000 to Laboratory showate: rarely (from ≥ 1/10000 to Local reactions:
Redness and soreness around the anus, irritation of the rectum, anus.
There are isolated reports of the development of thrombocytopenia and agranulocytosis. However, a causal relationship with the use of paracetamol has not been established.
Liver necrosis may occur following overdose.
If you experience side effects, inform your doctor. This applies to allex possible side effects includingundescribed in this leaflet.
Contraindications
Individual hypersensitivity to the drug components, severe liver and kidney dysfunction, deficiency of glucose-b-phosphate dehydrogenase (possible development hemolytic anemia), childhood up to 1 month of life, diseases of the blood system (anemia, thrombocytopenia, leukopenia), recent proctitis, anusitis or rectal bleeding, inflammation of the rectal mucosa and dysfunction of the anus; do not use for diarrhea.
Carefully
Paracetamol should be used with caution in the following cases:
Mild to moderate hepatocellular insufficiency; renal failure; Gilbert's syndrome (non-hemolytic familial jaundice); chronic alcoholism, overuse alcohol (drinking 3 or more doses of alcohol daily); anorexia, bulimia, or cachexia; Chronic malnutrition (low liver glutathione stores) dehydration, hypovolemia.
If a patient has an acute viral hepatitis treatment should be discontinued.
Precautions
There is a risk of local toxicity when using suppositories. The frequency of development and the severity of this side effect increase with an increase in the duration of use of suppositories, the frequency of their administration and the dosage level.
Do not use the drug at the same time as other medicines containing paracetamol, as this may cause an overdose of paracetamol.
When treating with paracetamol at a dose of 60 mg / kg / day, the simultaneous use of another antipyretic is justified only if paracetamol is ineffective. Do not exceed the recommended dose.
Do not use for diarrhea.
If the hyperthermia continues for more than 3 days during treatment or the state of health has worsened, you should consult a doctor.
Patients with moderate renal and / or hepatic impairment should consult a doctor before using paracetamol. Severe (severe) impairment of liver and / or kidney function is a contraindication to the use of the drug.
Paracetamol overdose can lead to liver failure (see the section "Overdose").
Cases of liver failure have been reported in patients with reduced glutathione levels in anorexia, low body mass index, chronic nutritional deficiency, chronic severe illness. In these patients, taking paracetamol may increase the risk of developing metabolic acidosis.
Use during pregnancy and lactation
Paracetamol crosses the placental barrier and is excreted with breast milk... In the case of the use of paracetamol during pregnancy and lactation, the expected benefits of therapy for the mother and the potential risk for the fetus and child should be carefully weighed.
Impact on the ability of the unituse vehicles or other machinery
Paracetamol has no or little effect on the ability to drive vehicles or other mechanisms.
Overdose
The risk of serious intoxication may be increased in the elderly, young children, in patients with liver disease, in chronic alcoholism, in patients suffering from exhaustion, taking inducers of liver microsomal enzymes. In such cases, overdose can be fatal. In case of overdose, you should immediately consult a doctor, even if the patient's condition does not cause concern.
Symptoms
During the first 24 hours after an overdose - pallor of the skin, nausea, vomiting, anorexia, malaise, sweating, abdominal pain. With a single administration of 10 g or more to adults or more than 150 mg / kg to children, cytolysis of hepatocytes occurs with complete and irreversible liver necrosis, the development of liver failure, metabolic acidosis and encephalopathy, which can lead to coma and death. 12-48 hours after the introduction of paracetamol, there is an increase in the activity of "hepatic" transaminases, lactate dehydrogenase, bilirubin concentration and a decrease in prothrombin content. Clinical symptoms liver damage usually appears 1-2 days after drug overdose and reaches a maximum on 4-6 days.
Treatment
Immediate hospitalization.
Determination of the quantitative content of paracetamol in blood plasma before starting treatment as much as possible early dates after an overdose. The introduction of SH-group donors and glutathione synthesis precursors - methionine and acetylcysteia - is most effective within 10 hours after an overdose. The need for further therapeutic measures (further administration of methionine, intravenous administration of acet1glcystsine) is determined by ~ 1m * depending on the concentration of paracetamol in the blood, as well as the time elapsed after its administration. Symptomatic treatment. Liver tests should be performed at the beginning of treatment and then every 24 hours. In most cases, the activity of "hepatic" transaminases is normalized within 1-2 weeks with complete recovery liver function. In very severe cases, a liver transplant may be required.
Interaction with other medicinal products
Phenytoin reduces the effectiveness of paracetamol and increases the risk of developing hepatotoxicity. Patients taking phenytoin should avoid frequent use of paracetamol, especially at high doses. Patients should be monitored to exclude hepatotoxicity.
Probenecid almost halves the clearance of paracetamol, inhibiting the process of its conjugation with glucuronic acid. With simultaneous use, consideration should be given to reducing the dose of paracetamol.
Salicylamide increases the half-life of paracetamol.
Caution should be exercised with the simultaneous use of paracetamol and inducers of microsomal liver enzymes (for example, ethanol, barbiturates, isoniazid, rifampicin, carbamazepine, anticoagulants, zidovudine, amoxicillin + clavulanic acid, phenylbutazone, tricyclic antidepressants) (see section "Overdose") (see).
Paracetamol, when taken in a dose of 4 g for at least 4 days, can enhance the effect of oral anticoagulants. The international normalized ratio (INR) should be monitored during and after the end of the simultaneous use of paracetamol (especially in high doses and / or for a long time) and anticoagulants (for example, warfarin); dose adjustment of the anticoagulant may be required.
Impact on laboratory tests
The use of paracetamol can affect the results of determining uric acid in blood serum by reaction with a phosphorus-tungsten reagent and determining the concentration of glucose in the blood by the glucose oxidase / peroxidase method.
If at presenttime or in the recent past you have taken other medicines, inform your doctor
The composition of the candles includes Paracetamol in various dosages and Witepsol as a candle mass.
Release form
Suppositories (suppositories) rectal for children V-shaped in a blister pack of 5 candles in a cardboard box No. 10.
pharmachologic effect
Analgesic, mild anti-inflammatory, antipyretic.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Children's Cefekon has analgesic and antipyretic effect ... In the central nervous system, the drug causes a blockade of cyclooxygenase, thereby affecting the pain center and the thermoregulation system. In the focus of inflammation, the influence paracetamol on cyclooxygenase is neutralized by cell peroxidase, which significantly reduces the anti-inflammatory effect. Cefecon does not negatively affect the gastrointestinal mucosa and water-electrolyte metabolism, that is, sodium water retention in the body is not observed.
Pharmacokinetics
The drug has high absorption, is rapidly absorbed through the mucous membrane. Easily overcomes the BBB. Possesses high bioavailability. It is distributed mainly in body fluids. Protein binding is negligible (less than 10%). Metabolized in the liver. The maximum concentration of the drug in the blood occurs within 10-60 minutes after taking it. It is excreted by the kidneys in the form of inactive metabolites (sulfates and glucuronides).
Indications for use
The drug is prescribed for children as:
- antipyretic ... Appointed when , , post-vaccination reactions, childhood infections and other conditions, raising body temperature;
- analgesic and with pain syndrome ( , myalgia , headache and toothache, pain in burns and injuries).
Contraindications
Children under 1 month old, hypersensitivity to paracetamol, chronic alcoholism. The drug must be prescribed with caution in diseases of the blood system, expressed kidney dysfunction and liver , genetically determined by the enzymatic absence of glucose-6-phosphate dehydrogenase.
Tsefekon D - candles at pregnancy and lactation can be prescribed taking into account the benefits and risks for the pregnant woman and the child (fetus). In studies of teratogenic, mutagenic and embryotoxic effects paracetamol not installed.
Side effects
Nausea, vomiting; anemia , agranulocytosis, leukopenia, thrombocytopenia; allergic reactions (itching and rash on mucous membranes and skin, ), development of papillary necrosis and interstitial jade , hemolytic anemia.
Instructions for Tsefekon D
The suppository is administered rectally to a child or adolescent. In the instructions for Tsefekon D candles for children, it is recommended to introduce candles after a cleansing enema. The suppository is administered 2 to 3 times a day. A single dose of Cefekon D on average should not exceed 15 mg per kilogram of the child's weight, and the maximum daily dose should be 60 mg.
A special purpose of the drug is required for children aged 1 to 3 months - a single administration of one suppository (0.05 g of paracetamol) per day.
At the age of 3 months to one year, with a child weighing 6-10 kg, the dose of the drug is 1-2 suppositories, 0.1 g each; 1-3 years old with a body weight of 10-15 kg 1-2 candles, 0.1 g each; 3-10 years (weight 16-32 kg) 1 candle 0.25 g each; 10-12 years old (weight 33-36 kg) 2 candles 0.25 g each.
Overdose
There is no information on drug overdose.
Interaction
When taken simultaneously with salicylates the risk of developing nephrotoxic action ... When administered simultaneously with the toxic effect increases chloramphenicol , the effectiveness of drugs that inhibit the synthesis and accelerate the excretion of uric acid decreases, the effect of indirect anticoagulants increases.
Terms of sale
Without recipe.
Storage conditions
At a temperature not exceeding 20 ° C.
Shelf life
Analogs
Matching ATX level 4:There are a lot of analogues of the drug "Children's Cefekon" containing paracetamol in its composition.
Let us mention just a few of them: Paracetamol for children , Tylenol for children , Bindard (effervescent powder for children), Daynafed EX , Volpan (powder), Daynafed junior , Dafalgan , Deminophen , Calpol 6 plus , Paracetamol MS , other.
Reviews about Tsefekon D
On numerous Internet forums discussing drugs for children, reviews of Tsefekon candles confirm the high effectiveness of the drug. Cefekon D is especially indispensable in cases where the child categorically refuses to take antipyretic and pain relievers in the form of a drink (syrups) or tablets, or the child starts vomiting after taking the syrup.
Some parents, if the child has a temperature, give him antibiotic that absolutely cannot be done without consulting a doctor. Do not forget that the temperature is a protective reaction of the body and should not be lowered within moderate limits. Give your child wet wipes and drink plenty of fluids.
Antipyretic suppositories Tsefekon for children is the best option, but one should not forget that children’s candles should not be taken from temperature for more than 3-5 days. In addition, the drug is not expensive. Information from the forums confirms that candles for children, the composition of which contains paracetamol, are quite popular among parents. Often on the forums they ask "how long do Cefekon D candles last?" As a rule, the effect appears in 15-20 minutes and lasts up to five hours.
Some parents are faced with the choice “which is better: Cefecon or ? " and can Cefekon and Nurofen be given to a child at the same time? These two drugs have different active substances (paracetamol and ibuprofen ). Everything here is individual. In some cases, Cefekon is more effective, in others, Nurofen. It is not recommended to give Cefecons Nurofen at the same time. If between taking, for example, Nurofen, the temperature rises, reduce it by rubbing. However, if your child has been taking Cefekon for five days and the temperature does not drop, then Cefekon must be replaced with another drug. But you cannot give the child one drug, between doses of another.
Sometimes parents use candles for adults to reduce the temperature of a child. This cannot be done, since most parents cannot correctly calculate the dose for the child. It is better to use a drug intended for children.
Cefekon D price where to buy
The price of Tsefekon candles for children 0.25 g No. 10 varies between 44 - 58 rubles per package. The price of candles Tsefekon D 0.05 g No. 10 is 34-42 rubles, and 0.1 g No. 10 is 38-47 rubles per package. You can buy the drug in most pharmacies in Moscow and other cities.
- Online pharmacies in RussiaRussia
- Online pharmacies of UkraineUkraine
- Internet pharmacies in KazakhstanKazakhstan
ZdravCity
Cefekon d supp. rekt. 100mg n10Nizhpharm OJSC
Cefekon d supp. rekt. 250mg n10Nizhpharm OJSC
Cefekon d supp. rekt. 50mg n10Nizhpharm OJSC
- G43 Migraine
- J06 Acute infections upper respiratory tract multiple and unspecified localization
- K08.8.0 * Toothache
- M79.1 Myalgia
- M79.2 Neuralgia and neuritis, unspecified
- R50 Fever of unknown origin
- R51 Headache
- R52.0 Acute pain
- T94.1 Sequelae of injury, unspecified by site
- T95.9 Consequences of unspecified thermal and chemical burns and frostbite
Composition and form of release
in a contour acheikova packing 5 pcs .; in a pack of cardboard 2 packages.
Description of the dosage form
Suppositories of white or white color with a creamy or yellowish tint, torpedo-shaped.
pharmachologic effect
Pharmacological action - analgesic, antipyretic, anti-inflammatory.
Pharmacodynamics
Paracetamol has analgesic and antipyretic effects. Blocks cyclooxygenase in the central nervous system, affecting the centers of pain and thermoregulation. In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on cyclooxygenase, which explains the absence of a significant anti-inflammatory effect.
The drug has no negative effect on water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa.
Pharmacokinetics
Absorption is high, rapidly absorbed from the gastrointestinal tract. The period of reaching C max is 30-60 minutes, binding to plasma proteins is 15%. Penetrates the BBB. The magnitude of the volume of distribution and bioavailability in children and newborns is similar to those in adults.
Metabolized in the liver: 80% - enters into conjugation reactions with glucuronic acid and sulfates with the formation of inactive metabolites; 17% - undergoes hydroxylation with the formation of active metabolites, which are conjugated with glutathione and form inactive metabolites. With a lack of glutathione, these metabolites can block the enzyme systems of hepatocytes and cause their necrosis. In newborns of the first two days of life and in children 3-10 years old, the main metabolite of paracetamol is paracetamol sulfate, in children 12 years of age and older - conjugated glucuronide.
T 1/2 - 2-3 hours. Within 24 hours 85-88% of paracetamol is excreted by the kidneys in the form of glucuronides and sulfates, unchanged - 3%. There is no significant age-related difference in the rate of elimination of paracetamol and in the total amount of the drug excreted in the urine.
Indications of the drug Cefekon ® D
Used in children from 3 months to 12 years old as:
antipyretic agent for acute respiratory infections, influenza, childhood infections, post-vaccination reactions and other conditions accompanied by an increase in body temperature;
pain reliever for pain syndrome of mild to moderate intensity, incl. headache and toothache, muscle pain, neuralgia, pain in trauma and burns.
In children from 1 to 3 months, a single dose of the drug is possible to lower the temperature after vaccination.
Contraindications
hypersensitivity to the components of the drug;
age up to 1 month of life.
Carefully:
impaired liver and kidney function;
gilbert's syndrome; Dubin-Johnson and Rotor;
diseases of the blood system (anemia, thrombocytopenia, leukopenia);
genetic absence of the enzyme glucose-6-phosphate dehydrogenase.
Side effects
From the digestive tract: nausea, vomiting, abdominal pain.
Allergic reactions: itching, rash on the skin and mucous membranes, urticaria, Quincke's edema.
From the side of the hematopoietic organs: anemia, leukopenia, agranulocytosis, thrombocytopenia.
With long-term use in large doses - hepatotoxic and nephrotoxic effects (interstitial nephritis, papillary necrosis), hemolytic anemia.
Interaction
Stimulants of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants), hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxication even with a small overdose.
Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic effects.
When taken together with salicylates, the nephrotoxic effect of paracetamol increases sharply.
The combination with chloramphenicol leads to an increase in the toxic properties of the latter.
Strengthens the effect of indirect anticoagulants, reduces the effectiveness of uricosuric drugs.
Method of administration and dosage
Rectally, after a cleansing enema or spontaneous bowel movement. The dosage of the drug is calculated depending on age and body weight, in accordance with the table. A single dose is 10-15 mg / kg 2-3 times a day after 4-6 hours. The maximum daily dose of paracetamol should not exceed 60 mg / kg.
Dosage of the drug for children of different ages
special instructions
If the fever continues for more than 3 days and the pain syndrome continues for more than 5 days, you should consult your doctor.
Simultaneous use of paracetamol with other paracetamol-containing drugs should be avoided, as this can cause an overdose of paracetamol.
When using the drug for more than 5-7 days, peripheral blood parameters and the functional state of the liver should be monitored. Paracetamol distorts laboratory tests in the quantitative determination of glucose and uric acid in plasma.
Manufacturer
JSC "Nizhpharm" (Russia).
Storage conditions of the drug Cefekon ® D
In a dry place, at a temperature not exceeding 20 ° C.
Keep out of the reach of children.
Shelf life of the drug Cefekon ® D
Do not use after the expiration date printed on the package.