Features of the use of the indirect anticoagulant phenylin. Medicinal guide Geotar Tablets nepheline application

What do they say about a drug like "Fenilin"? Feedback from doctors and patients will be considered at the very end of the article. We will also tell you about the purposes for which this remedy is prescribed, how to take it correctly, whether it has side effects, analogues and contraindications.

Composition and form

In what form is the medicine "Fenilin" produced? The instruction for use informs that this drug is available in tablets, active substance which is phenindione. Milk sugar, starch, citric acid and talc are used as auxiliary components.

Pharmacodynamics

What pharmacological features possesses the medicine "Fenilin"? The instructions for use state that this drug has a direct effect on It is an action.

Taking the medication contributes to the occurrence of hypoprothrombinemia, which is caused by a violation of the formation of prothrombin in the liver. Also, this tool significantly reduces the formation of factors 7, 9 and 10. At the same time, it has a greater cumulative effect in comparison with neodycoumarin.

After oral administration tablets, the concentration of blood coagulation factors decreases within 8-10 hours. The maximum effect of the drug is observed after 25-30 hours.

Pharmacokinetics

Is the "Fenilin" drug absorbed into the systemic circulation? Experts say that this medication is characterized by full and fairly rapid absorption. Its active ingredient penetrates the histo-hematic barriers and accumulates in tissues.

The drug is metabolized in the liver, and excreted by the kidneys (in the form of metabolites and unchanged).

Indications for use

For what purpose are Phenilin tablets prescribed? Experts say that this drug is used for treatment and prevention. The main indications for admission are thrombosis, thrombophlebitis, thromboembolic complications caused by embolic stroke and myocardial infarction, as well as similar disorders.

In addition, the medication in question is often prescribed to prevent blood clots after surgery.

Contraindications for use

Under what conditions of the patient is it forbidden to take the drug "Fenilin"? Instructions for use inform about the following contraindications:

• disorders in the work of the kidneys and liver;
• the initial level of prothrombin up to 70%;
• increased vascular permeability;
• and other diseases associated with decreased blood clotting;
• ulcerative diseases of the digestive tract;
• malignant neoplasms;
• pericarditis.

It should be said that the drug in question is not recommended for use at the very beginning of pregnancy, within a few days after childbirth and during menstruation.

The drug "Fenilin": instructions for use

The medication in question is used only for oral administration. Its therapeutic scheme has certain features, in this regard, use this medicine should only be prescribed by a doctor.

The initial daily dose of the drug is usually 0.11-0.17 g (4 times a day). The next day the amount drug reduced to 0.08-0.14 g, and later to 0.02-0.05 g. After that, the dosage of tablets depends on the level of prothrombin in the blood.

The maximum amount of the drug at a time should be 0.05 g, and the daily amount should be about 0.2 g.

For the prevention of thromboembolic complications, it is necessary to take 0.03 g of the drug per day, dividing this dose in half.

Therapy of acute thrombosis requires additional intake of heparin. This requires strict control by a doctor, as well as a mandatory systematic study of the amount of prothrombin in the blood and other factors of its coagulation.

Treatment with the drug "Fenilin", the analogs of which we will definitely list below, is gradually stopped.

Side effects

Does Phenilin cause side effects? The route of administration and dosage of this medication must be strictly observed. This is primarily due to the fact that during therapy, the patient may experience various allergic reactions in the form of diarrhea, nausea and hepatitis. Also, according to the reviews of doctors and patients, in rare cases headaches, fever, skin changes, and problems with hematopoiesis are observed.

Signs of overdose

In case of overdose, patients may aggravate symptoms that relate to side effects... As a treatment for such conditions, it is necessary to cancel the drug, as well as immediate intramuscular injection "Vikasola", the appointment of rutin, or vitamin P, calcium chloride, ascorbic acid and general symptomatic therapy.

Drug interaction of the drug "Fenilin"

From what this remedy is prescribed, we have described above. Let's move on to additional information.

When the drug in question is combined with "Heparin", salicylates, "Cymetidine" and sulfonamides, their anticoagulant effect may increase. At the same time, anabolic steroids, Allopurinol, Azathioprine, narcotic analgesics, Amiodarone, tricyclic antidepressants, antibiotics, glucocorticosteroids, androgens, Diazoxide, Disopyramide, Isoniazid, Butadion "," Metronidazole "," Clofibrate "," Alpha-tocopherol "," Reserpine "," Quinidine "," Paracetamol "," Disulfiram "," Cyclophosphamide "and hormones thyroid gland.

Vitamin K, Propranolol, ascorbic acid, urine alkalizing agents, Rifampicin, antacids, Fenazone, Haloperidol, barbiturates, oral contraceptives, diuretics, Meprotan, and Carbamazepine can significantly weaken the effect of phenindione. Kolestyramine ".

With extreme caution, this drug is prescribed to elderly patients, as well as to people with thromboembolism. pulmonary artery, hepatic and renal failure, erosive and ulcerative diseases of the digestive tract, in postpartum period and with pericarditis.

Treatment with "Fenilin" must be carried out under the special supervision of a doctor with a mandatory systematic blood test for the amount of prothrombin and other coagulation factors. Also, general urine tests are performed with the aim of early detection of hematuria.

In some patients, while taking the drug, urine may turn pink, and palms turn orange. This is due to the metabolism of phenindione.

The drug "Fenilin": analogues and cost

The main analogues of the agent under consideration are such drugs as "Warfapex", "Marevan", "Neodikumarin", etc.

You can buy the medicine "Fenilin" in the amount of 20 tablets for 120-140 rubles.

P No. 015073

Tradename: Phenylin

International non-proprietary name: phenindion

Dosage form:

pills

Composition

1 tablet contains:
active substance: phenindione 0.03 g;
Excipients: milk sugar, starch, talc, citric acid.

Description: tablets of white or white color with a creamy shade, flat-cylindrical, with a bevel.

Pharmacotherapeutic group:

indirect anticoagulant

ATX CODE: B01AA02.

Pharmacological properties
Pharmacodynamics:
Phenylin refers to drugs that affect blood clotting, indirect anticoagulants. It causes hypoprothrombinemia due to a violation of the process of prothrombin formation in the liver, and also reduces the formation of factors VII, IX and X. The cumulative effect of phenylin is greater than that of neodycoumarin. When taken orally, a decrease in the concentration of blood coagulation factors occurs 8-10 hours after taking phenylin and reaches a maximum after 24-30 hours.
Pharmacokinetics:
After oral administration, it is rapidly and almost completely absorbed. It passes histo-hematological barriers and accumulates in tissues. Metabolized in the liver. It is excreted by the kidneys unchanged and in the form of metabolites.

Indications for use.
Prevention and treatment of thrombosis, thrombophlebitis, thromboembolic complications in myocardial infarction, embolic (but not hemorrhagic!) Strokes, embolic damage to various organs; to prevent blood clots in the postoperative period.

Contraindications
Contraindicated with an initial level of prothrombin below 70%, with hemorrhagic diathesis and other diseases that are accompanied by a decrease in blood clotting, with increased vascular permeability, pregnancy (I trimester), impaired liver and kidney function, malignant neoplasms, ulcerative diseases of the gastrointestinal tract, pericarditis. Phenylin should not be prescribed during menstruation (the drug is stopped 2 days before the onset of menstruation) and in the first days after childbirth. It is prescribed with caution for pulmonary embolism (including in oncology), for the elderly.

Method of administration and dosage
The drug is administered orally. On the first day, take in a daily dose of 0.12-0.18 g (in 3-4 doses), on the second day - in a daily dose of 0.09-0.15 g, on the following days - 0.03-0. 06 g per day, depending on the level of prothrombin in the blood (the prothrombin index is maintained within 50-40%). The highest dose for adults inside: single - 0.05 g, daily - 0.2 g.
For the prevention of thromboembolic complications, 0.03 g is prescribed 1-2 times a day.
In acute thrombosis, phenylin is prescribed together with heparin. Treatment with phenylin is carried out under the strict supervision of a physician with a mandatory systematic study of the content of prothrombin in the blood and other factors of blood coagulation. Discontinuation of treatment should be carried out gradually.

Side effect
May cause allergic reactions (dermatitis, fever), diarrhea, nausea, hepatitis. Possible headache, fever, suppression of bone marrow hematopoiesis, with long-term use - micro and gross hematuria. In some patients, palms are colored orange, and urine pink. Rarely, phenylin can cause bleeding.

Overdose
The phenomena described in. The antagonist of phenylin overdose is vitamin K. In these cases, it is necessary to stop taking the drug and immediately begin intramuscular administration of vicasol (1-2 ml of a 1% solution 3 times a day), prescribe vitamin P or rutin, ascorbic acid, calcium chloride. According to indications, transfusion of fresh single-group blood is carried out in hemostatic doses (75-100 ml).

Interaction with other medicinal products
With simultaneous use with heparin, salicylates, sulfonamides, cimetidine, an increase in the anticoagulant effect is noted. Enhance the effect of anabolic steroids, azathioprine, allopurinol, amiodarone, narcotic analgesics, androgens, antibiotics, tricyclic antidepressants, urine oxidizing agents, glucocorticosteroids, diazoxide, disopyramide, isoniazid, nalidixic acid, clofibidazolate, paracetamide saline solutions, alpha-tocopherol, butadione, disulfiram, quinidine, cyclophosphamide, thyroid hormones.
Propranolol, urine alkalizing agents, vitamin K, ascorbic acid, antacids, phenazone, barbiturates, haloperidol, diuretics, carbamazepine, oral contraceptives, meprotan, rifampicin, colestyramine weaken the effect of phenindione.

special instructions
Treatment should be carried out under close medical supervision with a mandatory systematic study of the content of prothrombin in the blood and other coagulation factors. General urine tests are systematically performed for early detection of hematuria.
In some patients, palms are stained orange and urine pink, which is associated with the metabolism of phenylin and does not pose a danger.

Release form
Tablets of 0.03 g.
Packaging: 20 tablets in a blister, 20 or 50 tablets in jars.

Shelf life
3 years.
Do not use the drug after the expiration date.

Storage conditions
In a place protected from light and out of reach of children, at a temperature not exceeding 25 ° C. List A.

Terms of dispensing from pharmacies
With a doctor's prescription.

Enterprise - manufacturer
LLC "Pharmaceutical company" Health ". Address: Ukraine, 61013, Kharkov, Shevchenko st., 22. Representative office in Russia: CJSC" Ideal-PHARMACEUTICALS ", Russia

Name:

Name: Phenylinum (Phenylinum)

Indications for use:
Phenylin is used to reduce blood clotting for a long time in the prevention and treatment of thrombosis (the formation of a blood clot in a vessel); thrombophlebitis (inflammation of the vein wall with blockage); thromboembolic complications (blockage of blood vessels by a blood clot) in myocardial infarction; embolic strokes (acute disturbance of cerebral circulation as a result of blockage of cerebral vessels), but not hemorrhagic strokes (acute disturbance of cerebral circulation as a result of rupture of cerebral vessels); embolic lesions (blockage of a vessel by a blood clot or other foreign agent) of various organs. In surgical practice, they are also used to prevent thrombosis (formation of a blood clot) in the subsequent operational period.
Phenylin is also used in addition to heparin treatment.

Pharmachologic effect:
It belongs to the group of anticoagulants (drugs that inhibit blood clotting) of indirect action. It differs in structure from the products of the 4-hydroxycoumarin group, but in the mechanism of action it is close to them; causes hypoprothrombinemia (a decrease in the content of prothrombin in the blood - one of the blood clotting factors), associated with a violation of the process of prothrombin formation in the liver, and also causes a decrease in the formation of factors VII, IX, X (blood clotting factors).
Blood clotting slows down only after the introduction of phenylin into the body; in vitro (in vitro) this product does not have an anticoagulant effect.
A decrease in the concentration of coagulating factors occurs after 8-10 hours and reaches a maximum after 24-30 hours after taking phenylin.
The cumulative effect (the ability to accumulate in the body) is more pronounced than that of neodycoumarin.

Phenylin method of administration and dosage:
Usually prescribed on the 1st day in a daily dose of 0.12-0.18 g (in 3-4 doses), in the 2nd. a day at a daily dose of 0.09-0.15 g, then 0.03-0.06 g every day, depending on the content of prothrombin in the blood.
The prothrombin index (an indicator of the state of the blood coagulation system) is maintained at the level of 50-40%.
Higher doses for adults inside: single - 0.05 g, daily - 0.2 g.
For the prevention of thromboembolic complications (associated with blockage of blood vessels by a blood clot) complications are prescribed 1-2 times every day.
Treatment with phenylin is carried out under close medical supervision with a mandatory systematic study of the content of prothrombin in the blood and other coagulation factors.
In acute thrombosis (the formation of a blood clot in a vessel), phenylin is prescribed together with heparin.

Phenylin contraindications:
Phenylin is contraindicated when the initial prothrombin content is below 70%, hemorrhagic diathesis (increased bleeding) and other diseases accompanied by decreased blood coagulability, with increased vascular permeability, pregnancy, liver and kidney dysfunction, malignant neoplasms, ulcerative diseases of the gastrointestinal tract, pericarditis ( inflammation within the heart bag).
You should not prescribe neodikumarin during menstruation (the product is stopped 2 days before the onset of menstruation) and in the first days after childbirth. Caution is required when prescribing to the elderly. In some cases, headache, diarrhea, and allergic skin reactions are noted.
In case of bleeding, it is necessary to cancel the product, immediately proceed with the introduction of vitamin K, prescribe products of the vitamin P group, ascorbic acid, calcium chloride, transfusion of hemostatic doses (75-80 ml) of fresh single-group blood.
It should be borne in mind that the use of barbiturates in connection with the “induction” (activation) of liver enzymes weakens the effect of phenylin. In patients who received neodycoumarin at the same time as taking barbiturates, the cancellation of them in the aftermath while continuing to take neodycumarin in doses that caused the previously necessary decrease in the prothrombin index can lead to dangerous bleeding.
Simultaneously with phenylin (as with other anticoagulants), salicylates should not be prescribed, since they lead to dissociation (separation) of the neodycumarin complex with plasma proteins and an increase in the concentration of free anticoagulant in the blood.
Indirect anticoagulants can enhance the action of butamide, diphenin, glucocorticoids.

Phenylin side effects:
When treating with phenylin and other products of this group, you must carefully monitor general condition sick and changes in the blood coagulation system. At least 1 time in 2-3 days, it is necessary to determine the prothrombin index and examine the urine (taking into account the possibility of hematuria, which is an early sign overdose). Failure to follow this rule can lead to severe bleeding.
Phenylin and other indirect anticoagulants should be used with caution. With an overdose and prolonged use, they can cause serious complications (bleeding) associated not only with changes in blood clotting, but also
with an increase in capillary permeability (the smallest vessels). Micro- and gross hematuria (invisible and visible with the eye the discharge of blood with urine), bleeding from the oral cavity and nasopharynx, gastric and intestinal bleeding, muscle hemorrhages, etc.
It should be borne in mind that the determination of the prothrombin index (according to the one-step Quick method) is not always sufficient to identify the changes that have occurred in the blood coagulation system. Hemorrhages (bleeding) can also occur when normal numbers prothrombin; therefore, for more complete control, it is necessary to conduct other studies. It is recommended to study tolerance (resistance) to heparin, plasma fibrinogen, recalcification time and prothrombin index or (if possible) prothrombin content (determination is made by a two-step method).

It is imperative to eliminate these diseases in time, otherwise much more serious consequences may arise. One of the most effective drugs that is used to treat various diseases veins Phenilin. It has long established itself as effective remedy for the treatment of clogged veins, inflammation, etc.

This is a synthetic type agent that prevents increased blood clotting. The instructions indicate that this is an indirect action. The main component of the drug is phenindione.

It is due to it that blood coagulability decreases, blood clots dissolve, inflammation and other unpleasant sensations in the legs pass.

Composition and form of release

1 tablet contains the following components:

• the main component is phenindione 0.03 grams;
• additional components - milk sugar, starch powder, talc, citric acid.

Pills white, sometimes there is a creamy shade. The shape of the tablets is cylindrical.

It is produced in cardboard boxes with blisters and glass jars.

Pharmaceutical properties of the drug

The drug Phenilin is part of the group of anticoagulants with an indirect effect (drugs that slow down effect on blood clotting).

The active ingredient, phenindione, causes hypoprothrombinemia, which is associated with problems in the formation of prothrombin in the liver.

It also leads to a decrease in the formations of the VII, IX, X coagulation factors of the blood composition, a decrease in the level of plasma tolerance to heparin, the presence of lipid components in the blood composition and an increase in the permeability properties of the vascular walls.

The action of the drug begins in 8-10 hours and reaches the maximum concentration level 24-30 hours after taking the drug.

This product has a fast and complete absorption. The main substance of the drug passes through barriers of the histo-hematous type and accumulates in tissues. The metabolic process takes place in the liver. Excretion of the substance occurs through the kidneys unchanged and in the form of metabolites.

Indications for use

Fenilin is recommended to be taken during increased blood clotting, it has an inhibitory effect on blood clotting. It is often prescribed during treatment and for the prevention of thrombotic diseases. It should be understood that with thrombosis, this remedy is taken for a long time.

In addition, according to the instructions, this medicine must be taken for the treatment and prevention of conditions:

Also, this agent can be taken in the postoperative period to prevent various complications.

When not to prescribe a remedy

According to the instructions, the drug should not be taken in the following situations:

• if there is an individual intolerance to the constituent components of the drug;
• if the initial content of prothrombin is less than 70%;
• during various diseases, during which there is reduced blood clotting;
• in cases of high vascular permeability;
• if there are abnormalities in the functioning of the liver and kidneys;
• during pericarditis;
• with malignant neoplasms;
• if there is a stomach ulcer, duodenum and other erosive and ulcerative lesions of the gastrointestinal tract;
• should not be taken during pregnancy and lactation.

Instructions for use

The medicine is prescribed to be taken orally according to the following scheme:

• first day - per day you need to take from 0.12 to 0.20 grams, about 3-4 doses;
• on the second day - per day from 0.9 to 0.15 grams 2-3 doses;
• on the third day and subsequent days - per day from 0.03 to 0.06 grams, depending on the level of prothrombin in the blood.

After that, depending on the patient's condition and depending on the individual dynamics of the decrease in prothrombin in the blood composition, the dosage of Fenilin is reduced to 0.01-0.02 at a time. On average, the duration of the course of treatment is 2 to 3 weeks.

How to take for thrombosis and thrombophlebitis

When and the drug should be taken in a dose of 0.003 to 0.005 grams at a time. You need to take pills 2 times a day.

The duration of this appointment is 2 days. After that, the dosage is reduced - 0.002-0.001 grams per dose, it is also taken 2 times a day.

It is taken until the diseases disappear completely - 2-3 weeks.

How to take during thromboembolic complications

During preventive treatment complications of a thromboembolic nature should be taken in a dosage of 0.002 to 0.03 grams per dose, 2 times per day. You need to take it within 2-3 weeks.

How to take for acute thrombosis

During thrombosis in acute form you need to take Phenilin together with. The dosages are the same as for the usual form of thrombosis. Maximum oral dosage: single - 0.05 grams, daily - 0.20 grams.

During treatment, the level of prothrombin in the blood composition should not be reduced below 40%.

Side effects

While taking the drug, the following side effects may occur:

Interaction with other drugs

If taken simultaneously with ACTH, the anticoagulant effect may increase.

During the reception together with Dipyridamole, cases of increased bleeding are described. Perhaps this is due to a decrease in platelet adhesion and aggregation under the influence of Dipyridamole.

When taken together with Klofibrator, the anticoagulant effect increases.

During simultaneous administration with Liotronin, Miconazole, Cimetidine, Ethylestrinol, there is an increase in the anticoagulant effect of Phenilin.

Practical application experience

After studying the reviews of doctors and patients who take Phenilin, certain conclusions can be drawn.

Phenilin drug good remedy for prophylaxis with increased blood clotting. In addition, its use during thromboembolic diseases gives good results.Many of my patients after treatment with this remedy note that they feel much better. But before taking the medicine Fenilin, it is still worth consulting with a doctor, he will be able to conduct an examination and prescribe the correct treatment.

Phlebologist

Phenylin - good drug, both for prevention and treatment, thrombosis, thromboembolism. It helps with blockage of veins, blood vessels, relieves inflammation, and also prevents increased blood clotting.

But still, do not forget about contraindications and side effects... Therefore, before you start taking this remedy, be sure to consult your doctor.

Vascular surgeon

I always suffered from thrombophlebitis, he just gave me no rest. What were these swelling and pain worth. Than I just did not treat this disease, but the effect was always temporary.

After the examination, the doctor prescribed Fenilin to take. I took it for 2 weeks according to the instructions. After the treatment, I noticed good improvements. After the examination, the doctor noted that my vessels and veins became clear, the inflammation was gone, and the pains disappeared.

But still the disadvantage is that there are too many contraindications, so this remedy is not suitable for everyone!

Svetlana, 54 years old

When I noticed swelling of my legs and severe pain I immediately went to the doctor. After the examination, it was found that I have thrombosis and thrombophlebitis.

The doctor prescribed to take Phenilin along with heparin. She took the drug according to the instructions for 3 weeks. Already in the second week, I noticed tangible changes - the swelling disappeared, it became less, it passed. And at the end of the reception, these symptoms completely disappeared and do not bother me to this day. A year has passed after the treatment, and my legs are like new!

Marina, 42 years old

The cost of the drug

The cost of a package with 20 tablets is about 75-80 rubles, the cost of package No. 10 is from 40 to 50 rubles, the price of a package of Fenilin with 30 tablets is from 110 to 130 rubles.

Analogs of the drug are available:

Phenylin - medicinal product anticoagulant action.

Release form and composition

Phenylin is available in the form of tablets: flat-cylindrical, with a beveled, white or creamy-white color (20 pcs. In blister or cell-free packs; 20 or 50 pcs. In cans; in a cardboard box 1 pack or 1 can).

Composition of 1 tablet:

• active substance: phenindione - 30 mg;
• auxiliary components: starch, citric acid, milk sugar, talc.

Pharmacological properties

Pharmacodynamics

Phenylin is an indirect anticoagulant. The drug causes hypoprothrombinemia, disrupting the formation of prothrombin in the liver, and reduces the formation of coagulation factors VII, IX and X. The cumulative effect of Phenilin is more pronounced than that of neodycoumarin. With oral administration of the drug, a decrease in the concentration of coagulation factors is observed after 8-10 hours after administration, and the maximum decrease occurs after 24-30 hours.

Pharmacokinetics

The drug is rapidly and almost completely absorbed after oral administration. Phenylin crosses histohematogenous barriers and is able to accumulate in tissues.

Metabolism takes place in the liver. The drug is excreted by the kidneys both as metabolites and unchanged.

Indications for use

Phenylin is used to treat and prevent the following diseases:

• thrombophlebitis;
• thrombosis;
• embolic (but not hemorrhagic) strokes;
• thromboembolic complications in myocardial infarction;
• embolic damage to various organs.

The drug is also used to prevent the formation of blood clots in the postoperative period.

Contraindications

Absolute:

• increased vascular permeability;
• hemorrhagic diathesis and other diseases accompanied by a decrease in blood clotting;
• baseline prothrombin level less than 70%;
• pericarditis;
• malignant neoplasms;
• menstrual period;
• pregnancy period (first trimester);
• postpartum period;
• lactation period;
• hypersensitivity to the components of the drug.

Relative (Phenilin is used with caution):

• thromboembolism of the pulmonary artery (including in oncology);
• dysfunction of the kidneys and liver;
• erosive and ulcerative lesions of the gastrointestinal tract;
• elderly age.

Method of administration and dosage

Phenylin is intended for oral administration.

On the first day of treatment, take 120-180 mg of the drug (3-4 times), on the second day - 90-150 mg, on the following days - 30-60 mg per day, depending on the concentration of prothrombin in the blood (it is necessary to maintain the prothrombin index within 50–40%). Maximum doses for adults: single - 50 mg, daily - 200 mg.

In order to prevent thromboembolic complications, Phenilin is prescribed 30 mg 1-2 times a day.

In acute thrombosis, the drug is taken simultaneously with heparin.

Side effects

• digestive system: toxic hepatitis, nausea, liver dysfunction, diarrhea;
• cardiovascular system: myocarditis;
• central nervous system: headache;
• hematopoietic system: oppression of hematopoiesis in the bone marrow;
• blood coagulation system: with long-term treatment - bleeding from the nasopharynx and oral cavity, microhematuria, gross hematuria, muscle hemorrhages, bleeding from the gastrointestinal tract;
• urinary system: impaired renal function;
• allergic reactions: dermatitis, skin rash, fever, eosinophilia.

Overdose

In case of an overdose of Phenilin, the appearance and enhancement of the listed side effects may occur.

The antagonist is vitamin K. In case of an overdose, the drug should be discontinued and the immediate administration of vicasol should be started (1-2 ml of a solution of 1% concentration three times a day intramuscularly). Vitamin P or rutin, calcium chloride and vitamin C are also prescribed. If indicated, transfusion of one-group blood is performed in hemostatic doses.

special instructions

Throughout the entire period of therapy with Phenilin, the patient should be under strict medical supervision. It is necessary to systematically determine the level of prothrombin and other clotting factors, as well as carry out general analysis urine for the early detection of hematuria.

In some patients, it is possible to stain the palms in orange, and urine in pink, which is due to the peculiarities of the metabolism of the drug and does not pose a danger.

Treatment with Phenilin should be discontinued gradually.

Influence on the ability to drive vehicles and complex mechanisms

The drug does not affect the ability of patients to drive vehicles and work with other complex mechanisms.

Application during pregnancy and lactation

Phenilin is contraindicated for use during pregnancy (in the first trimester) and during breastfeeding. It is recommended to avoid using the drug in the first days after childbirth.

Phenylin should be discontinued two days before the onset of menstrual bleeding and should not be used during the entire period.

With impaired renal function

In patients with renal insufficiency, the drug is used with caution.

For violations of liver function

In patients with liver failure the drug is used with caution.

Use in the elderly

Elderly patients are prescribed Fenilin with caution.

Drug interactions

The anticoagulant effect of the drug is enhanced by simultaneous use with adrenocorticotropic hormone, clofibrate, liothyronine, miconazole, cimetidine or ethylestrenol. In all these cases, there is a risk of bleeding.

When Fenilin and dipyridamole are taken together, an increase in bleeding is possible (since dipyridamole, apparently, reduces the adhesiveness and aggregation of platelets).

Analogs

The analogues of Phenilin are: Atrombone, Gedulin, Diofindan, Dindevan, Pindion, Trombozol, Tromazal, Thrombotil, Thrombantin, Fenindion, Phenylindandion.

Terms and conditions of storage

Store in a dark place at a temperature not exceeding 25 ° C. Keep out of the reach of children.

The shelf life is 3 years.