Gaviscon 10 ml instructions for use. Gaviscon quick help to normalize digestion and heartburn

Instructions for use

Active ingredients

Release form

Suspension

Composition

Active ingredient: Sodium alginate, Potassium bicarbonate active substance (mg): 1200

Pharmacological effect

Antacid drug. after oral administration, the drug quickly interacts with the acidic contents of the stomach. in this case, an alginate gel is formed, which prevents the occurrence of gastroesophageal reflux. during regurgitation, the gel enters the esophagus, where it reduces irritation of the mucous membrane.

Pharmacokinetics

The mechanism of action of the drug Gaviscon forte does not depend on absorption into the systemic circulation.

Indications

Symptomatic treatment of dyspepsia associated with increased acidity of gastric juice and gastroesophageal reflux (heartburn, sour belching); feeling of heaviness in the stomach after eating, incl. during pregnancy.

Contraindications

Hypersensitivity to drug components; childhood up to 6 years old.

Precautions

The drug should be stored out of the reach of children at a temperature of 15 ° to 30 ° C.

Application during pregnancy and lactation

It is possible to use the drug Gaviscon forte during pregnancy and lactation (breastfeeding).

Method of administration and dosage

Inside, after meals and before bedtime. Adults and children over 12 years old - 10-20 ml. The maximum daily dose is 80 ml. Children 6-12 years old - 5-10 ml. The maximum daily dose is 40 ml. For older patients, dose changes are not required.

Side effects

Possible allergic reactions.

Overdose

Symptoms: bloating. Treatment: symptomatic therapy.

Interaction with other drugs

The drug contains calcium carbonate, which exhibits antacid activity, therefore, at least 2 hours should pass between taking Gaviscon forte and other drugs, especially when used simultaneously with histamine H2 receptor blockers, antibiotics from the tetracycline group, digoxin, fluoroquinolones, iron salts , ketoconazole, neuroleptics, thyroxine, penicillamine, beta-blockers, GCS, chloroquine, diphosphates.

special instructions

10 ml of suspension contains 106 mg (4.6 mmol) sodium and 78 mg (2 mmol) potassium. This should be considered when it is necessary to follow a diet with limited salt content (with congestive heart failure, impaired renal function) or while using medicines, which can cause the development of hyperkalemia. It should be borne in mind that 10 ml of the suspension contains 200 mg (2 mmol) of calcium carbonate. Therefore, care should be taken to prescribe the drug for hypercalcemia, nephrocalcinosis and recurrent formation of kidney stones containing calcium. In the absence of improvement within 7 days, the patient should consult a doctor. Effect on the ability to drive vehicles and control mechanisms The drug does not affect the ability to drive vehicles and mechanisms. , as well as for classes by other potentially dangerous species activities requiring increased concentration of attention and speed of psychomotor reactions.

Active ingredients: sodium alginate 500 mg, sodium bicarbonate 213 mg, calcium carbonate 325 mg.

pharmachologic effect

This drug is a combination of alginate and antacids (calcium carbonate and sodium bicarbonate). Pharmacodynamics. When taken orally, the drug quickly reacts with the acidic content of the stomach. This forms an alginate gel with an almost neutral pH value. The gel forms a protective coating on the surface of the stomach contents and lasts up to 4 hours, effectively preventing the occurrence of gastroesophageal reflux. In the case of regurgitation, the gel enters the esophagus, where it reduces irritation of the mucous membrane. Calcium carbonate quickly neutralizes the gastric acid hydrochloric acid, relieving heartburn. This effect is enhanced by the presence of sodium bicarbonate in the preparation, which also has a neutralizing effect. Pharmacokinetics. The mechanism of action of the active substances of the drug does not depend on absorption into the systemic circulation.

Indications for use

Symptomatic treatment of diseases associated with indigestion, high acidity of gastric juice and gastroesophageal reflux (heartburn, sour belching), feeling of heaviness in the stomach, discomfort after eating.

Mode of application

Inside. Adults and children over 12 years old: 10 - 20 ml after meals and before bedtime (up to 4 times a day). The maximum daily dose is 80 ml. For elderly patients, dose changes are not required.

Interaction

Since calcium carbonate, which is part of the drug, exhibits antacid activity, at least 2 hours should pass between taking the drug and other drugs (especially when taking H2-histamia receptor blockers, antibiotics from the tetracycline group, digoxin, fluoroquinolones, iron salts, ketoconazole, antipsychotics, levothyroxine sodium, penicillamine, beta-blockers, glucocorticoeteroids, chloroquine and diphosphates).

Side effect

In rare cases, allergic reactions are possible (urticaria, bronchospasm, anaphylactic reactions). Taking a large amount (more than recommended doses) of calcium carbonate can cause alkalosis, hypercalcemia, lactic-alkaline syndrome, the phenomenon of "rebound", constipation.

Contraindications

Increasing sensitivity to any component of the drug. Children up to age 12. With care: severe renal dysfunction; hypophosphatemia; hypercalcemia; nephrocalcinosis. Application during pregnancy and during the period breastfeeding... The drug can be used during pregnancy and lactation.

Overdose

Symptoms: flatulence. Treatment: symptomatic.

special instructions

In 10 ml of the suspension, the sodium content is 127.25 mg (5.53 mmol). This should be taken into account when it is necessary to follow a diet with limited salt content, for example, with congestive heart failure and dysfunction of the night. 10 ml of suspension contains 130 mg (3.25 mmol) of calcium. Therefore, caution should be exercised when treating patients with hypercalcemia, nephrocalcinosis, and recurrent calcium-containing kidney stones. The drug contains antacids, which can mask symptoms serious diseases gastrointestinal tract. A decrease in the effectiveness of the drug in patients with very low levels of gastric acidity is possible. In children with gastroenteritis or suspected of having renal failure there is an increased risk of hyperpatremia. Do not use the drug for a long time, if there is no improvement in the condition within 7 days, you should consult your doctor. Effect on the ability to drive machinery and a car. The drug does not affect the ability to drive vehicles and mechanisms, as well as to engage in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Suspension for oral administration is viscous, opaque, from almost white to light brown in color, with a mint odor. 10 ml in a multilayer sachet - 12 sachets per pack.

pharmachologic effect

Antacid drug.

Gaviscon Dual Action is a combination of alginate and antacids (calcium carbonate and sodium bicarbonate).

When taken orally, the drug quickly reacts with the acidic contents of the stomach. This forms an alginate gel with an almost neutral pH value. The gel forms a protective membrane on the surface of the stomach contents and lasts up to 4 hours, effectively preventing the occurrence of gastroesophageal reflux. In the case of regurgitation, the gel enters the esophagus, where it reduces irritation of the mucous membrane. Calcium carbonate quickly neutralizes the gastric acid hydrochloric acid, relieving heartburn. This effect is enhanced by the presence of sodium bicarbonate in the preparation, which also has a neutralizing effect.

Indication for use

Symptomatic treatment of diseases associated with indigestion, increased acidity of gastric juice and gastroesophageal reflex (heartburn, sour belching), feeling of heaviness in the stomach, discomfort after eating.

Method of administration and dosage

The drug is taken orally.

Adults and children over 12 years old are prescribed 10-20 ml (1-2 sachets) of the suspension after meals and before bedtime (up to 4 times / day). The maximum daily dose is 80 ml (8 sachets).

No dose adjustment is required for elderly patients.

Contraindications

• moderate to severe renal failure;
• children under 12 years of age;
• hypersensitivity to any of the components of the drug.

special instructions

The drug can be used during pregnancy and lactation.

10 ml of suspension contains 127.25 mg (5.53 mmol) sodium. This should be taken into account when it is necessary to adhere to a diet with limited salt content, for example, with congestive heart failure and impaired renal function.

10 ml of suspension contains 130 mg (3.25 mmol) of calcium. Therefore, caution should be exercised when treating patients with hypercalcemia, nephrocalcinosis, and recurrent calcium-containing kidney stones.

Gaviscon Dual Action contains antacids, which can mask the symptoms of serious gastrointestinal diseases. A decrease in the effectiveness of the drug in patients with very low levels of gastric acidity is possible.

Children with gastroenteritis or suspected renal failure have an increased risk of hypernatremia.

Do not use the drug for a long time. If there is no improvement in the condition within 7 days, the patient should consult a doctor.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 30 ° C; do not freeze.

* alginate drug. Anti-regurgitant. Sometimes called.
Gaviscon ® forte(lat. Gaviscon forte) - a drug other than Gaviscon increased content active substance - sodium alginate.
Gaviscon ® Double Action - a new version of Gaviscon, registered in Russia in April 2012.

Active substances drug Gaviscon forte. 10 ml of suspension for oral administration contains: sodium alginate 1000 mg, potassium bicarbonate 200 mg. (In Gaviscon forte, as well as in Gaviscon, calcium carbonate is contained, however, unlike Gaviscon, it belongs to auxiliary substances in Gaviscon forte.)

Active substances chewable tablets... One tablet of Gaviscon contains sodium alginate 250 mg, sodium bicarbonate 133.5 mg and calcium carbonate 80 mg.

Excipients suspensions of Gaviscon and Gaviscon forte: carbomer, sodium saccharinate, methyl parahydroxybenzoate, propyl parahydroxybenzoate, peppermint oil, sodium hydroxide, purified water. Gaviscona excipients in tablets: mannitol, macrogol, magnesium stearate, aspartame, copovidone, potassium acesulfame, lemon (or mint) flavor.

It is produced in the form of a suspension for oral administration, packaged in 10 ml sachets, and bottles of 150, 200, 300 and 600 ml, as well as chewable tablets. One chewable tablet contains: sodium alginate 250 mg, sodium bicarbonate 267 mg and calcium carbonate 160 mg. 10 ml of suspension for oral administration contains: sodium alginate 500 mg, sodium bicarbonate 213 mg and calcium carbonate 325 mg.

Application of Gaviscon

Indications for the use of Gaviscon and Gaviscon forte: symptomatic treatment dyspepsia associated with increased acidity of the stomach and gastroesophageal refluxes (heartburn, sour belching), a feeling of heaviness in the stomach after eating, including during pregnancy.

The figure on the right (from the work of Mayev I.V. et al.) Shows the mechanism of action of sodium alginate - the active substance of Gaviscon.

The main pharmacological and clinical effects of Gaviscon are associated with the presence of alginic acid, which is presented in the formulation as sodium alginate. When Gaviscon alginates interact with gastric acid hydrochloric acid, the latter is neutralized, a gel is formed that protects the esophageal mucosa, protecting it from further exposure to hydrochloric acid and pepsin, which is manifested in a significant weakening of dyspeptic and pain... At the same time, protection against reflux of gastric contents into the esophagus is provided. It is in the formation of a mechanical barrier-raft, which prevents the reflux of stomach contents into the esophagus, that the main mechanism of action of Gaviscon lies. Potassium bicarbonate, which is part of Gaviscon forte, is a source of carbon dioxide and makes the raft "buoyant", while calcium carbonate binds to each other long molecules of alginate to strengthen the formed protective barrier. The antireflux properties of Gaviscon are universal not only in terms of significance and time interval, but also in terms of quality characteristics. By creating a protective barrier on the surface of gastric contents, Gaviscon is able to significantly and for a long time, more than 4.5 hours, reduce the number of both pathological gastroesophageal refluxes and duodenogastroesophageal refluxes, thereby creating conditions for physiological "rest" for the esophageal mucosa. It is important that the mechanism of action of Gaviscon is of a physical nature and, therefore, it is devoid of systemic action, in contrast to nonabsorbable antacids, which can affect an increase in the levels of aluminum in plasma and urine when taking aluminum-containing drugs and the consistency of stools (Pakhomova I.G. and etc.).

Figure 2 is taken from the article by M.A. Butov. with co-authors.

The key reason for the appearance of pathological gastroesophageal and pharyngolaryngial refluxes, in which aggressive refluxate from the stomach penetrates the ENT organs and the bronchopulmonary system, is the lack of the antireflux barrier. In this case, the acidity of the gastric contents can be normal or even low, that is, the development of the disease is mainly associated with the ingress of gastric contents into a place that is not physiological for it. In this regard, it is advisable to use alginates, which temporarily reduce the acidity of the stomach. The only drug in this group, which has recently appeared in Russia, is Gaviscon (Soldiersky Yu.L.).

Acute pharmacological test with Gaviscon, carried out at the Central Research Institute of Gastroenterology in 10 patients under the control of pH monitoring, demonstrated its antireflux effect lasting from 1.5 to 3.5 hours. At the same time, the generalized De Meester indicator has normalized or decreased significantly. The average gastric acidity in 3 patients did not change, in 7 patients there was a moderate antacid effect due to the bicarbonates that make up the drug (Bordin D.S., Masharova A.A., Kozhurina T.S.).

Method of administration and dosage: Gaviscon, Gaviscon forte and Gaviscon are taken orally, after each meal and before going to bed:

• Adults and children over 12 years old take Gaviscon 10-20 ml of suspension. The maximum daily dose is 80 ml.
• Adults and children over 12 years old take Gaviscon forte, 5-10 ml of suspension. The maximum daily dose is 40 ml.
• Children from 6 to 12 years old take Gaviscon 5-10 ml. The maximum daily dose is 40 ml (Instructions for the use of Gaviscon and Gaviscon forte suspension).
• Adults and children over 12 years old take 2-4 tablets of Gaviscon or Gaviscon double action at each dose
• For children under 12 years of age, the dosage regimen for Gaviscon tablets is established by the doctor (Instructions for the use of Gaviscon tablets).

The tablets are chewed thoroughly when taken. Elderly age patients do not require dosage changes.

The use of Gaviscon during pregnancy and breastfeeding

Gaviscon, one of the few antacids allowed to be taken during pregnancy and breastfeeding. This is due to the physical, not the biochemical nature of its mechanism of action - Gaviscon forms an alginate “raft barrier” in the stomach, which prevents gastric acid from entering the esophagus, as well as the fact that the main components of Gaviscon are not absorbed into the systemic circulation.

Professional medical publications regarding the use of Gaviscon in the treatment of the gastrointestinal tract:

• Bordin D.S., Masharova A.A., Kozhurina T.S. Treatment of gastroesophageal reflux disease with alginates // Attending physician. - 2008. - No. 6.


• Bubyakina V.N., Pakhomova I.G., Uspensky Yu.P. Pathogenetic substantiation of the prospects for the clinical use of the alginate-containing drug "Gaviscon" in patients with chronic pancreatitis combined with GERD // BC. - 2007. - No. 28. - p. 2171-2176.


• Pakhomova I.G., Tkachenko E.I., Uspensky Yu.P. The first Russian experience of using "Gaviscon" in the treatment of gastroesophageal reflux disease // BC. - 2007. - Volume 15. - No. 22. - p. 1639-1642.


• Soldiersky Yu.L. Otolaryngological manifestations of gastroesophageal reflux disease // Diseases of the digestive system. - 2007. - Volume 9. - No. 2. - p. 42-47.


• Beri F.D., Dettmar U., Johnston L.M., Lorsch U., Sykes D., Toubel D., Hampson F.Ch. Suppression of gastroesophageal reflux with alginates. Breast cancer. Diseases of the digestive system. 2008, volume 10, no. 2, p. 83-86.


• Elokhina T.B., Tyutyunnik V.L. Gastroesophageal reflux disease during pregnancy // BC. - 2008. - Volume 16. - No. 19. - p. 1243-1247.


• Vasiliev Yu.V., Yanova O.B., Kozhurina T.S., Bordin D.S. Experience of using Gaviscon in the elimination of gastroesophageal reflux in patients with gastroesophageal reflux disease // Gastroenterology. - 2008. - No. 2. - from. 3-5.


• Shcherbinina M.B., Morozova N.K. Gaviscon forte is a reliable assistant in the treatment of GERD // News of Medicine and Pharmacy. Gastroenterology (thematic issue). - 2008 .-- 239.


• Plotnikova E.Yu. Relevance of antacids and alginates for heartburn // iDoctor. Gastroenterology. 2015.09.S. 14-18.


• Denisova O.A., Livzan M.A. Possibilities of using the alginate test in the diagnosis of GERD // Experimental and Clinical Gastroenterology. 2015. Issue 117. No. 5. S. 67–70.


• Butov M.A., Markova E.V., Faleev V.V. Monotherapy with alginates in patients with gastroesophageal reflux disease // Doctor. 2013. No. 12. P. 42–46.


• Instructions for medical use medicinal product Gaviscon forte (suspension for oral administration [anise], [mint]), approved by the Ministry of Health of Russia on 17.04.17 (pdf, download)
• Instructions for the medical use of the drug Gaviscon Double Action (suspension for oral administration [mint]), approved by the Ministry of Health of Russia on 08.16.16 (pdf, download)
• Official Information for UK Health Professionals ( english language, pdf) "UKPAR Gaviscon Double Action Liquid"

general information

In Gaviscon, there are 141 mg (6.2 mmol) sodium per 10 ml of suspension. This can be important when following a salt-free diet, which may be necessary in cases of congestive heart failure and kidney disease.

Contraindications: age up to 6 years (for Gaviscon), age up to 12 years (for Gaviscon forte), hypersensitivity to drug components.

Side effects: allergic reactions are possible.

Antacid drug. Symptomatic treatment of dyspepsia associated with increased acidity of gastric juice and gastroesophageal reflux (heartburn, acid belching, feeling of heaviness in the stomach after eating, including during pregnancy). The drug is prescribed orally for adults and children over 12 years of age, 5 -10 ml after meals and before bedtime. The maximum daily dose is 40 ml.

Gaviscon® Dual Action is a combination of alginate and antacids (calcium carbonate and sodium bicarbonate). When taken orally, the drug quickly reacts with the acidic contents of the stomach. This forms an alginate gel with an almost neutral pH value. The gel forms a protective membrane on the surface of the stomach contents and lasts up to 4 hours, effectively preventing the occurrence of gastroesophageal reflux. In the case of regurgitation, the gel enters the esophagus, where it reduces irritation of the mucous membrane. Calcium carbonate quickly neutralizes the gastric acid hydrochloric acid, relieving heartburn. This effect is enhanced by the presence of sodium bicarbonate in the preparation, which also has a neutralizing effect.

- symptomatic treatment of diseases associated with indigestion, increased acidity of gastric juice and gastroesophageal reflux (heartburn, sour belching), feeling of heaviness in the stomach, discomfort after eating.

The drug is taken orally. Adults and children over 12 years old appoint 10-20 ml of suspension after meals and before bedtime (up to 4 times / day). The maximum daily dose is 80 ml. For elderly patients dose adjustment is not required.

In rare cases (<1/10 000) возможны allergic reactions (urticaria, bronchospasm, anaphylactic reactions). Taking calcium carbonate in doses higher than recommended can cause alkalosis, hypercalcemia, lactic-alkaline syndrome, rebound phenomenon, and constipation.

- children up to age 12; - hypersensitivity to any component of the drug. Carefully: - severe renal dysfunction; - hypophosphatemia; - hypercalcemia; - nephrocalcinosis.

Symptoms: flatulence. Treatment: carrying out symptomatic therapy.

10 ml of suspension contains 127.25 mg (5.53 mmol) sodium. This should be taken into account when it is necessary to adhere to a diet with limited salt content, for example, with congestive heart failure and impaired renal function. 10 ml of suspension contains 130 mg (3.25 mmol) of calcium. Therefore, caution should be exercised when treating patients with hypercalcemia, nephrocalcinosis, and recurrent calcium-containing kidney stones. Gaviscon® Dual Action contains antacids that can mask the symptoms of serious gastrointestinal diseases. A decrease in the effectiveness of the drug in patients with very low levels of gastric acidity is possible. Children with gastroenteritis or suspected renal failure have an increased risk of hypernatremia. Do not use the drug for a long time. If there is no improvement in the condition within 7 days, the patient should consult a doctor. Influence on the ability to drive vehicles and use mechanisms The drug does not affect the ability to drive vehicles and mechanisms, as well as to engage in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

The preparation contains calcium carbonate, which exhibits antacid activity, therefore, at least 2 hours should elapse between taking Gaviscon® Double Action and other drugs, especially when used simultaneously with histamine H2 receptor blockers, antibiotics from the tetracycline group, digoxin, fluoroquinolones, iron salts, ketoconazole, neuroleptics, levothyroxine sodium, penicillamine, beta-blockers, GCS, chloroquine and diphosphates.

The drug should be stored out of the reach of children at a temperature not exceeding 30 ° C; do not freeze. Shelf life is 2 years.