Precuting MV: Instructions for use, analogues and reviews, prices in pharmacies of Russia. Preduat MV: instructions for use, analogues and reviews, prices in pharmacies of Russia Trimetazidine or predict what is better

One of the most popular and demanded medicines, effective in combating symptoms ischemic Disease Hearts are the pills "preacht". Feedback on the use of this drug is contradictory. This is due to the fact that along with extreme effectiveness, this medication does not heal the disease, but only removes its symptoms. How appropriate, the use of the medication "predet" will be discussed in our article.

general characteristics

There are preparations whose use has earned numerous positive feedback. "Precut" is one of them. This drug has the ability to level the consequences of oxygen starvation of brain nerve cells and the heart muscle due to the activation of metabolism. The drug "preoccupy" improves in cells experiencing an oxygen deficiency, therefore it is prescribed to patients suffering from coronary heart disease, for the prevention of angina, as well as with the retil (worsening vision) and cochleto-baural (change in hearing, dizziness, noise in the ears) violations.

Varieties

Currently, two types of the same drug are produced - it "preoccupied" and "pretty MV". They possess the same therapeutic effect, as they contain one active substance - Trimetazidine. So what kind of drugs did the most laudatory reviews deserve? "Precuting MV" Some are considered more efficient, as it is created by special technology, at the expense of its main active substance It is slower, and therefore, the impact on the body has a longer. Other differences between these two drugs not. Everyone can choose the one that does it seems better to him on subjective reasons.

Dosage form

The dosage form of the above-described drugs is almost identical. They both are produced in the form of tablets. In the package with a medicine "predet", they are contained sixty pieces, and "pretty MV" is sold at 300, 180, 90, 60 units in a pack. Both those and other tablets have a biconide form and painted in fault in white color. However, some differences are still available. The tablets "prettral MV" pink color, and "preoccupy" - red-orange.

Structure

The drug "Pretended MV", the reviews of which will be presented below, contains in one tablet 35 mg of trimetazidine. In a weaker "preoccupative", this substance is present in a much lesser concentration - only 20 mg. But the auxiliary components in these medicines are different. "Precuting MV" consists of calcium hydrophosphate dihydrate, hypimonlolo, iron oxide of red, colloidal silicon oxide. "Precuting" - from corn starch, aluminum yellow varnish, moisture aluminum, Mannitol Talca. These drugs and general components are glycerol, poveidone, titanium dioxide, hypimosellos, macrogol 6000, magnesium stearate.

Therapeutic action

Trimetazidine supports the stable level of ATP in tissues and due to this ensures normal life of the cell under conditions of oxygen deficiency. In addition, this substance slows down and stimulates the utilization of glucose, which is necessary for the formation of energy and requires a smaller amount of oxygen. It is this process that underlies therapeutic effect Preparations "preoccupy" and "pretty MV".

Patient reviews indicate that these drugs have the following properties:

• Slow development caused exercise (from the fifteenth day of therapy).
• Reduce the hesters of blood pressure associated with excessive overwork.
• Reduce the frequency and intensity of the attacks of angina.
• Level the need for nitroglycerin.
• Stimulate blood circulation.
• Improve hearing with deafness caused by ischemic heart disease.
• Enhance the visual sharpness associated with oxygen starvation.

Indications for use

• With ischemic heart disease, pills "pretty MV" and "preoccatted" are applied. Reviews of cardiologists indicate that they are effective with long-term therapy in order to prevent angularity attacks.
• To eliminate cochleto-baulous disorders (dizziness, hearing impairment, eared noise) in LOR-Practice, the drugs described by us are also used.
• In ophthalmology, medicines "predatory MV" and "preoccupy" are no less in demand: they eliminate the dystrophy and retinal atrophy of the eye caused by an oxygen deficiency.

Instructions for use

The tablets "predette" need to swallow the whole during meals, drinking with a small amount of water. Usually they are prescribed one thing two or three times a day. Therapy, as a rule, continues for several months, its duration depends on the appointment of the attending physician. The daily concentration of medication in the blood should not exceed 60 mg, which corresponds to the three tablets. The use of more drug is fraught with negative consequences, as evidenced by feedback. "Precontal" in a strong concentration provokes sharply pronounced sideflines.

The tablets "Preteat MV" should be taken in one thing twice a day - in the morning and evening. They need to be absorbed, not chewing, while eating, drinking water. The daily maximum dosage of the drug in the blood is 70 mg (two tablets). To avoid side Effects It should not be exceeded. The duration of the application "preoccupied MV" is also several months (under the close observation of the attending specialist).

Side effects

Preparations "predet" and "preoccupied MV" can cause the same side effects. By clinical trials and prolonged patient monitoring, it was found that they can provoke some violations of organs and systems.

• From the head of the gastrointestinal tract, it may be observed: nausea, abdominal pain, diarrhea, constipation, vomiting, phenomena of dyspepsia (swelling of the abdomen, exterior, extinguishing gases, heartburn, etc.).
• From the CNS: dizziness, asthenia, acneezia (the inability to make arbitrary desired movements), headaches, tremor, instability in the pose of romberg, an increase in muscle tone, syndrome restless legs, Specific Parkinsonic Sweetness Gait, Sleepiness, Insomnia.
• Skin and subcutaneous fatty tissue may suffer from rashes, itching, urticaria, acute generalized examatosis Pustulose and quinque swelling.
• From side of cardio-vascular system: extrasystolia, heartiness feeling, strong decline arterial pressure, Tachycardia is tilted to the skin of the face, (drop in pressure during the transition to standing).
• In the blood and lymph after the use of the drug, the following violations may appear: agranulocytosis (decrease in basophils, neutrophils and eosinophils), thrombocytopenia.
• In addition, in some cases, the use of the medication described by us can cause hepatitis.

The fact that the above side effects disappear immediately after the cancellation of the drug is confirmed by numerous reviews. "Precontal", nevertheless, should be taken with caution, under the supervision of the doctor.

TRIMETAZIDINE TRIMETAZIDINE (ATC) CC01EB15):

Commercial names abroad - VASTAREL MR, Flavedon Mr, Cardaptan, Idaptan, Carvidon Mr, Trizedon MR, Vestar, Carmetadin.

Precuting - Review of the Cardiologist:

I will say briefly: in cardiology the drug is absolutely useless, none with any pathology therapeutic effect does not.

There is extra money - buy and take.

Precuting MV (trimetazidine) - instructions for use. The preparation is prescription, information is intended only for health professionals!

Clinical and Pharmacological Group:

The drug that improves the metabolism of myocardium and neurosensory bodies in the conditions of ischemia

pharmachologic effect

Precontract® MV prevents a decrease in the intracellular content of ATP by preserving the energy metabolism of cells in a state of hypoxia. Thus, the drug ensures the normal functioning of membrane ion channels, transmembrane transfer of potassium and sodium ions and the preservation of cellular homeostasis.

Trimetazidine slows down the oxidation of fatty acids due to the selective inhibition of long-chain 3-ketoacetyl-coolas, which leads to an increase in glucose oxidation and the restoration of the interface between glycolysis and oxidative decarboxylation and causes the protection of myocardium from ischemia. Switching oxidation of fatty acids to the oxidation of glucose underlies the antichangal effect of trimetazidine.

It is experimentally confirmed that trimetazidine has the following properties:

• maintains the energy metabolism of the heart and neurosensory organs during ischemia;
• reduces the amount of intracellular acidosis and the degree of changes in the transmembrane ion flow arising under ischemia;
• lowers the level of migration and infiltration of polynuclear neutrophils in ischemic and reperfusion tissues of the heart;
• reduces myocardial damage;
• there is no direct impact on hemodynamic performance.

In patients suffering from angina, trimetazidine:

• increases the coronary reserve, thereby slowing the development of ischemia caused by exercise, starting from the 15th day of therapy;
• limits sharp hesitation of blood pressure, caused by exercise, without any significant changes in heart rate;
• significantly reduces the frequency of angina attacks and the need for a short-acting nitroglycerin;
• improves the contractile function of the left ventricle in patients with ischemic dysfunction.

IN clinical studies The duration of 2 months was shown that the addition of the drug predatal® MV at a dose of 35 mg to the therapy with atenolol in a dose of 50 mg after 12 hours led to a significant slowdown in the offensive of the ischemic depression of the ST segment when carrying out load tests.

Pharmacokinetics

Suction

After taking the drug inside the trimetazidine is quickly absorbed. Cmax is achieved after 5 hours. More than 24 hours, the plasma concentration remains at a level exceeding 75% of the concentration, determined after 11 hours. Meal does not affect the pharmacokinetic properties of the drug.

Distribution

CSS is achieved after 60 h. Vd is 4.8 l / kg, which indicates a good distribution of trimetazidine in tissues.

Binding with plasma proteins is low, about 16% (in vitro).

Election

It is excreted from the body mainly by the kidneys unchanged. T1 / 2 - about 7 hours, patients over 65 years old - about 12 hours.

The kidney clearance of trimetazidine directly correlates with the CC, the hepatic clearance decreases with age.

It was shown that in the elderly patients with a daily dose of 2 tablets in 2 receptions, an increase in the exposure in the blood plasma does not lead to any pronounced effects compared with placebo.

Indications for the use of the drug predtal® MV

• cardiology: Long-term IBS therapy, prevention of attacks stable angina (monotherapy or in combination therapy);
• ENT diseases: treatment of cochleo-vestibular violations of ischemic nature, such as dizziness, noise in the ears, hearing impairment;
• ophthalmology: chorioretinal disorders with ischemic component.

Method of application and dosage

Precontract® MV is prescribed 1 tablet 2 times a day during meal in the morning and in the evening. The duration of therapy is established individually.

Tablets take inside entirely, not chewing and drinking water.

Side effect

Determination of development frequency adverse Reactions: Very often (\u003e 1/10), often (\u003e 1/100,<1/10), нечасто (1/1000, <1/100), редко (1/10 000, <1/1000); очень редко (<1/10 000), включая отдельные случаи.

From the digestive system: often - abdominal pain, diarrhea, dyspepsia, nausea, vomiting.

From the CNS: often - dizziness, headache; Very rarely - extrapyramidal symptoms (trembling, rigidity, acinesis), reversible after the cancellation of the drug.

From the side of the cardiovascular system: rarely orthostatic hypotension, blood tides to the skin of the face.

Allergic reactions: often - skin rash, itching, urticaria.

Others: often - asthenia.

Contraindications for the use of the drug predtal® MV

• pronounced renal failure (QC less than 15 ml / min);
• increased sensitivity to the components of the drug.

Due to the lack of sufficient clinical data, it is not recommended to prescribe the drug to children and adolescents under the age of 18.

With caution should be prescribed to patients with severe liver failure (clinical data are limited).

Application of the drug preoccupative® MV during breastfeeding and breastfeeding

In experimental studies, the teratogenic effect of trimetazidine was not established. However, due to the lack of clinical data, the drug is not recommended to be applied during pregnancy.

It is not known whether trimetazidine is distinguished with breast milk. Therefore, if necessary, the appointment of the drug during the lactation should stop breastfeeding.

Application with violations of liver function

Due to the lack of appropriate clinical data, the prescription of the drug preoccupied® MV is not recommended for patients with severe liver function disorders.

Application with violations of the kidney function

Due to the lack of appropriate clinical data, the prescription of the drug preoccupied® MV is not recommended to patients with renal failure with QC less than 15 ml / min.

special instructions

It should be borne in mind that precomply® MV is not intended to relocate angina seizures and is not shown for the initial course of the therapy of unstable angina or myocardial infarction, as well as in preparing for hospitalization or in the first days.

In the event of the development of the attack of angina, it should be revised and adapting treatment (drug therapy or revascularization).

Impact on the ability to driving vehicles and control mechanisms

Precuting® MV slightly affects the ability to driving a car and performing work requiring high velocity of psychomotor reactions. In connection with the possible development of dizziness and other side effects, caution should be taken when operating by vehicles and occupations by other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Overdose

There is limited information on the overdose of trimetazidine.

In case of overdose, the symptomatic therapy is carried out.

Medicinal interaction

Medicinal interaction of the drug preoccupatic® MV is not described.

Conditions of vacation from pharmacies

The drug is released by a doctor's prescription.

Terms and Storage Terms

No special storage conditions required. Keep out of the reach of children. Shelf life - 3 years.

Polish drug predict MV is intended for the treatment of heart pathologies. The key component of the means is represented by trimetazidine dihydrochloride in a volume of 35 mg in each tablet.

Vero-Trimetazidin

Russian substitute for fixed assets in tablet form. It has the same permissions and prohibitions for use that I predict MV.

Reception permits depend on the scope of application:

• in cardiological practice - with long-term treatment of IBS, in order to prevent the formation of attacks of the angina of a stable flow, as a drug of monotherapy or comprehensive effects;
• in otolaryngological - therapy of the problem of foreign stall in the ears, attacks of dizziness, hearing impairment, coordination of movements formed under the influence of ischemia;
• in ophthalmologic - dystrophic changes in the choriocapillary layer of the vascular envelope of the organs of vision with ischemic features.

• with flashes of spontaneous allergies with respect to the ingredients;
• with significant kidney dysfunction with QC indicators less than 15 units;
• at the moment of having a baby and his breast feeding;
• for patients who have not achieved complete majority - there is no sufficient information about the harm of medication.

The attention of specialists should be directed to patients with serious liver failure.

Dosing

The drug takes 0.02 g, three times a day, simultaneously with the meal. If the variant of the drug with a modified form of liberation is prescribed, then the dosage is 0.035 g twice a day.

Side effect

Zhkt.

SCS.

CNS.

Dermis

Antishen

A domestic substitute in its instructions duplicates basic information about the main medicine.

Reception permits depend on the scope of application:

• in cardiological practice - with long-term treatment of IBS, in order to prevent the formation of attacks of the angina of a stable flow, as a drug of monotherapy or comprehensive effects;
• in otolaryngological - therapy of the problem of foreign stall in the ears, attacks of dizziness, hearing impairment, coordination of movements formed under the influence of ischemia;
• in ophthalmologic - dystrophic changes in the choriocapillary layer of the vascular envelope of the organs of vision with ischemic features.

• with flashes of spontaneous allergies with respect to the ingredients;
• at the moment of having a baby and his breast feeding;
• for patients who have not achieved complete majority - there is no sufficient information about the harm of medication.

Dosage

Therapy is carried out in conjunction with meals, from 2 to 3 tablets daily. The main course appoints the attending physician.

Side effect

The tool can become a source of non-standard response of the body:

Zhkt.- painful sensations in the area of \u200b\u200bthe abdominal cavity, digestive disorders with a liquid chair, dyspeptic deviations with bits of vomiting or nausea.

SCS.- Hot riding to face, orthostatic version of the hypotension.

CNS. - attacks of acute headache with dizziness, involuntary trembling limbs, muscle rigidity, axinesia: symptoms of extrapyramidal deviations by independently after the cancellation of the medication.

Dermis - Dermatological itching, rash, nettle syndrome.

Separate patients may have asthenic syndrome.

Angic Retard

A substitute from Macedonia in tablets duplicate readings and prohibitions to receive a fixed assessment.

Dosing

The medicine is applied twice a day on one tablet, together with the morning and evening meals. The duration of the procedures is established by a doctor for each patient separately.

Side effect

In some cases, gastric pains, nausea or vomiting, headaches, accelerated heartbeat, allergic reactions with dermatological itch were recorded.

RIMECOR

The domestic analogue was predicted by MV in a tablet version that have the same testimony and prohibitions for the application as the main medication.

Dosing

Therapeutic procedures are carried out together with food intake. Standard dosage includes 2 or 3 tablets equal to 0.04-0.06 g, the daily amount is divided into several receptions. The duration of treatment is determined individually for each ill.

Side effect

The drug can be the source of the formation of gastric discomfort, felling and attacks of vomiting, pronounced dermis itch. In rare cases, there is a headache and severe heartbeat.

Defrene MV

Substitute for domestic production in tablets with full duplication of side effects, permits and contraindications to apply the main medication.

Dosing

The drug is accepted together with morning and evening food, one tablet. The duration of therapy depends on the appointments of the precinct specialist.

Side effect

The tool can become a source of non-standard response of the body:

Zhkt.- painful sensations in the area of \u200b\u200bthe abdominal cavity, digestive disorders with a liquid chair, dyspeptic deviations with bits of vomiting or nausea.

SCS.- Hot riding to face, orthostatic version of the hypotension.

CNS. - attacks of acute headache with dizziness, involuntary trembling limbs, muscle rigidity, axinesia: symptoms of extrapyramidal deviations by independently after the cancellation of the medication.

Dermis - Dermatological itching, rash, nettle syndrome.

Separate patients may have asthenic syndrome.

Dibico

Tableted Russian substitute predicted mV.

Indications

The remedy is prescribed under CH of various origin, against the background of the body poisoning with cardiac glycosides, with two types of diabetes mellitus.

Contraindications

Reception is prohibited for juvenile patients and patients with severe and allergic reactions to individual components of the drug.

Dosing

Against the background of the CH - reception from 0.25 to 0.5 g, twice a day, 20 minutes before meals. The duration of therapy is equal to one calendar month. It is allowed to increase the initial doses to 3 g per day or their decrease to 0.125.

On the background of 2 types of diabetes - 0.5 g, twice a day. It is allowed to use the drug as a means of monotherapy or its combination with other drugs that reduce glucose indicators in the bloodstream.

Against the background of 1 type of diabetes mellitus - 0.5 g twice a day. Insulin therapy is additionally produced, the overall treatment course can reach the first half of the year.

Side effect

The medication can lead to outbreaks of allergic reactions.

Preizer

Hungarian agent against heart disease with similar data in the attached instruction.

Indications

• in cardiological practice - with long-term treatment of IBS, in order to prevent the formation of attacks of the angina of a stable flow, as a drug of monotherapy or comprehensive effects;
• in otolaryngological - therapy of the problem of foreign stall in the ears, attacks of dizziness, hearing impairment, coordination of movements formed under the influence of ischemia;
• in ophthalmologic - dystrophic changes in the choriocapillary layer of the vascular envelope of the organs of vision with ischemic features.

Dosing mode

The drug is accepted with morning and evening food, on one tablet, treatment time depend on the instructions of the doctor.

Side effect

The tool can become a source of non-standard response of the body:

Zhkt.- painful sensations in the area of \u200b\u200bthe abdominal cavity, digestive disorders with a liquid chair, dyspeptic deviations with bits of vomiting or nausea.

SCS.- Hot riding to face, orthostatic version of the hypotension.

CNS. - attacks of acute headache with dizziness, involuntary trembling limbs, muscle rigidity, axinesia: symptoms of extrapyramidal deviations by independently after the cancellation of the medication.

Dermis - Dermatological itching, rash, nettle syndrome.

Separate patients may have asthenic syndrome.

Contraindications for use

Prohibited therapeutic procedures:

• with flashes of spontaneous allergies with respect to the ingredients;
• with significant dysfunction of the liver or kidney with QC indicators less than 15 units;
• at the moment of having a baby and his breast feeding;
• for patients who have not achieved complete majority - there is no information about the championship of the drug.

pharmachologic effect

Precuting ® MV prevents a decrease in the intracellular content of ATP by preserving the energy metabolism of cells in a state of hypoxia. Thus, the drug ensures the normal functioning of membrane ion channels, transmembrane transfer of potassium and sodium ions and the preservation of cellular homeostasis.

Trimetazidine slows down the oxidation of fatty acids due to the selective inhibition of long-chain 3-ketoacetyl-coolas, which leads to an increase in glucose oxidation and the restoration of the interface between glycolysis and oxidative decarboxylation and causes the protection of myocardium from ischemia. Switching oxidation of fatty acids to the oxidation of glucose underlies the antichangal effect of trimetazidine.

It is experimentally confirmed that trimetazidine has the following properties:

- maintains the energy metabolism of the heart and neurosensory organs during ischemia;

- reduces the amount of intracellular acidosis and the degree of changes in the transmembrane ion flow arising during ischemia;

- lowers the level of migration and infiltration of polynuclear neutrophils in the ischemic and reperfusion tissues of the heart;

- reduces myocardial damage;

- There is no direct impact on hemodynamic performance.

In patients suffering from angina, trimetazidine:

- increases the coronary reserve, thereby slowing the development of ischemia caused by exercise, starting from the 15th day of therapy;

- limits sharp hesitation of blood pressure, caused by exercise, without any significant changes in heart rate;

- significantly reduces the frequency of angina attacks and the need for a short-acting nitroglycerin;

- improves the contractile function of the left ventricle in patients with ischemic dysfunction.

The results of the clinical studies have confirmed the effectiveness and safety of the use of trimetazidine in patients with stable angina, both in monotherapy and as part of combined therapy in case of insufficient treatment efficacy by other drugs.

In a randomized double-blind placebo-controlled study with the participation of 426 patients with stable angina (TRIMPOL-II), the addition of trimetazidine (60 mg / day) to the treatment with metoprolol 100 mg / day (50 mg 2 times / day) for 12 weeks is statistically reliably Improved the results of load tests and clinical symptoms compared with placebo: the total duration of load tests was +20.1 C, P \u003d 0.023, the total load time of the load +0.54 Mets, P \u003d 0.001, time to the development of the depression of ST segment per 1 mm +33.4 s, p \u003d 0.003, time before the development of the attack of angina +33.9 s, p<0.001, количество приступов стенокардии в неделю -0.73, р=0.014 и потребление нитратов короткого действия в неделю 0.63, р=0.032, без гемодинамических изменений.

In a randomized double-blind placebo-controlled study with the participation of 223 patients with stable angina (sellier), the addition of trimetazidine at a dose of 35 mg 2 times / day to the therapy at atenolol at a dose of 50 mg 1 time / day for 8 weeks led to an increase in time to the development of ischemic Depression ST segment per 1 mm (+34.4 C, p \u003d 0.03) When carrying out load tests in a subgroup of patients (n \u003d 173), compared with placebo, 12 hours after receiving the drug. This difference was also shown for the development of angina attacks (P \u003d 0.049). Revealed reliable differences between groups for other secondary endpoints (the total duration of load tests, the total load time and clinical endpoints).

In a three-month-old randomized double-blind study with the participation of 1962 patients with stable angina (VASCO) trimetazidine in two dosages (70 mg / day and 140 mg / day), in comparison with the placebo, Atenolol's therapy was added (50 mg / day). In the overall population, including patients, both without symptoms and symptoms of angina, trimetazidine did not demonstrate advantages on ergometric (total length of load tests, time before the ischemic depression of ST segment per 1 mm and time before the development of angina) and clinical endpoints . However, in a retrospective analysis in a subgroup of patients with stenocardia symptoms (N \u003d 1574), trimetazidine (140 mg) has significantly improved the total load test time (+23.8 С compared to +13.1 C for placebo; p \u003d 0.001) and time before the development of the attack of angina region ( +46.3 C compared to +32.5 C for placebo; p \u003d 0.005).

Pharmacokinetics

Suction

After taking the drug inside the trimetazidine is quickly absorbed. Max is achieved after 5 hours. More than 24 hours, the plasma concentration remains at a level that exceeds 75% of the concentration determined after 11 hours. Meal does not affect the bioavailability of the drug.

Distribution

SS is achieved after 60 hours. V D is 4.8 l / kg, which indicates a good distribution of trimetazidine in tissues.

Binding with plasma proteins is low, about 16% (in vitro).

Election

It is excreted from the body mainly by the kidneys unchanged. T 1/2 - about 7 hours, patients over 65 years old - about 12 hours.

The kidney clearance of trimetazidine directly correlates with the CC, the hepatic clearance decreases with age.

Pharmacokinetics in special groups of patients

In patients over the age of 75, an increased exposure of trimetazidine may be observed due to the age reduction of the kidney function. A special study was conducted in the population of patients under the age of 75 when taking trimethazidine tablets of 35 mg 2 times / day. Analysis conducted by the kinetic population method showed on average two-time increase in blood plasma in patients with renal failure of severe (QC<30 мл/мин) по сравнению с пациентами с КК >60 ml / min. No features regarding the safety of the use of the drug in patients over the age of 75 in comparison with the overall population was not found.

The exposition of trimethazidine was average increased by 2.4 times in patients with renal insufficiency of secondary severity (KK 30-60 ml / min) and, on average, 4 times - in patients with severe renal failure (QC<30 мл/мин) по сравнению со здоровыми добровольцами с нормальной функцией почек. Никаких особенностей касательно безопасности применения препарата у этой популяции пациентов в сравнении с общей популяцией обнаружено не было.

Pharmacokinetics of trimetazidine in children and adolescents under the age of 18 were not studied.

Indications

- Long-term therapy of IBS: Prevention of seizures of stable angina in the form of monotherapy or as part of combination therapy.

Dosing mode

Precuting ® MV assign 1 tab. 2 times / day during meals in the morning and in the evening. The maximum daily dose is 70 mg.

The duration of treatment is determined by the doctor.

Tablets should be taken inside entirely, not chewing and drinking water.

W. patients with renal insufficiency of moderate severity (QC 30-60 ml / min) The daily dose is 35 mg (1 tab.). Tablets should be taken in the morning, during breakfast.

W. patients over the age of 75 An increased exposure of trimetazidine due to the age reduction of the kidney function may be observed. Select the dose with caution.

Side effect

Unwanted reactions defined as undesirable phenomena at least having a possible attitude towards treatment with trimetazidine are given in the following gradation: very often (≥1 / 10); Often (≥1 / 100,<1/10); нечасто (≥1/1000, <1/100); редко (≥1/10 000, <1/1000); очень редко (<1/10 000); неуточненной частоты (частота не может быть подсчитана по доступным данным).

From the digestive system:often - abdominal pain, diarrhea, dyspepsia, nausea, vomiting; Uncomfortable frequency - constipation.

From the CNS: Often - dizziness, headache; Unspecified frequency - symptoms of Parkinsonism (tremor, akinesia, increasing tone), instability in pose of romberg and "praying" gait, "Restless legs" syndrome, other motor disorders, usually reversible after cancellation, sleep disorders (insomnia, drowsiness) .

From the side of the skin and subcutaneous fatty tissue: often - skin rash, itching, urticaria; Unspecified frequency - acute generalized examature Pustulose, swelling of quinque.

From the side of the cardiovascular system: Rarely - a feeling of heartbeat, extrasystolia, tachycardia, a pronounced decline in blood pressure, orthostatic hypotension, which can be accompanied by general weakness, dizziness or loss of equilibrium, especially with the simultaneous admission of hypotensive drugs, "tides" of the blood to the skin of the face.

From the side of the hematopoietic system: Uncomfortable frequency - agranulocytosis, thrombocytopenia, thrombocytopenic purpura.

From the side of the liver and biliary tract: Uncomfortable frequency - hepatitis.

General violations: Often - asthenia.

Contraindications for use

- severe renal failure (QC less than 30 ml / min);

- Parkinson's disease, Parkinsonism symptoms, tremor, restless leg syndrome and other associated motor disorders;

- Increased sensitivity to any of the components of the drug.

FROM caution It should be prescribed the drug to patients with renal failure of severe (QC<30 мл/мин) (клинические данные ограничены), пациентам с почечной недостаточностью средней степени тяжести (КК 30-60 мл/мин), пациентам в возрасте старше 75 лет.

Application in pregnancy and breastfeeding

Data on the use of the drug pregnant ® MB in pregnant women are missing.

Animal studies did not reveal the presence of direct or indirect reproductive toxicity.

Reproductive toxicity studies have not shown the effects of trimetazidine on the reproductive function in rats of both sexes.

Data on the selection of trimetazidine or its metabolites in breast milk is absent. The risk for a newborn / child cannot be excluded. It should not be applied to the drug predict ® MB during breastfeeding.

Application in children

Due to the lack of sufficient clinical data, it is not recommended to prescribe the drug to children and adolescents under the age of 18.

Overdose

There is limited information on the overdose of trimetazidine.

In case of overdose, the symptomatic therapy is carried out.

Medicinal interaction

The drug interaction of the drug predetal ® MV is not described.

Conditions of vacation from pharmacies

The drug is released by a doctor's prescription.

Terms and Storage Terms

No special storage conditions required. Keep out of the reach of children. Shelf life - 3 years. Do not apply after the expiration date indicated on the package.

Application with violations of liver function

FROM caution The drug should be prescribed to patients with severe liver failure (clinical data are limited).

Application with violations of the kidney function

Contraindicated in pronounced renal failure (QC less than 30 ml / min).

FROM caution A drug should be prescribed to patients with moderate renal failure.

Application in elderly patients

It should be prescribed with caution to be prescribed ® MB older patients over 75 years old, which can increase its exposure.

special instructions

Precuting ® MV is not intended to relocate angina seizures and is not shown for the initial course of the therapy of unstable angina or myocardial infarction at the prehospital stage or in the first days of hospitalization.

In the event of the development of the attack of angina, it should be revised and adapting treatment (drug therapy or conducting a revascularization procedure).

Precuting ® MB can cause or worsen Parkinsonism symptoms (tremor, akinesia, increasing tone), therefore, regular observation of patients, especially elderly, should be carried out. In doubtful cases, patients should be sent to a neurologist for an appropriate examination.

When motor disorders appear, such as Parkinsonism Symptoms, Restless Leg Syndrome, Tremor, Instability in the Romberg Pose and "Skateness" of the gait, predict ® MB should be finally canceled.

Such cases are rare and symptoms usually pass after the termination of therapy: in most patients - for 4 months after the cancellation of the drug. If the symptoms of Parkinsonism persist more than 4 months after the cancellation of the drug should be consulted by the neurologist.

Cases of falling, associated with instability in the Romberg Pose and the "scalance" of the gait or a pronounced decrease in blood pressure, especially, in patients receiving hypotensive drugs may be occurring.

It should be prescribed with caution preoccupied ® MB patients who have to increase its exposure:

- with renal insufficiency of medium and severe;

- Elderly patients over 75 years old.

Impact on the ability to driving vehicles and control mechanisms

During clinical studies, the influence of the drug predicts ® MB on hemodynamic indicators, but during the period of the post-registration application, there were cases of dizziness and drowsiness, which may affect the ability to control the vehicle and performing work requiring increased speed of physical and mental reactions.

Preclutten OD: Instructions for use and reviews