Oxamp - instructions for use, indications, dosage for children and adults, release form, composition and price. Oxamp sodium powder: instructions for use Oxamp sodium instructions for use

Antibiotic of the penicillin group of broad spectrum of action, resistant to penicillinase

Active ingredients

Release form, composition and packaging

Powder for preparation of solution for intramuscular injection

Powder for preparation of solution for intravenous administration (or a porous mass) of white with a yellowish tinge, forming a transparent, almost colorless solution upon dissolution.

Bottles with a volume of 10 ml (10) - cardboard boxes.
Vials with a volume of 10 ml (50) - cardboard boxes.

pharmachologic effect

Combined antibacterial drug.

Oxacillin is an antibiotic from the group of semi-synthetic penicillins. Acts bactericidal, suppressing the synthesis of the bacterial cell wall. Resistant to the action of penicillinase. Staphylococcus spp. (including those producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis; gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis; an aerobic bacteria: spore-forming rods, Actinomyces spp. To oxacillin are stable most gram-negative bacteria, rickettsia, viruses, protozoa, fungi.

Ampicillin is an antibiotic from the group of semi-synthetic penicillins. Acts bactericidal, suppressing the synthesis of the bacterial cell wall. Active against gram-positive bacteria: Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp. (including Enterococcus spp.), non-spore-forming bacteria (including Listeria monocytogenes); gram-negative aerobic bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Bordetella pertussis, some strains of Haemophilus influenzae.

Ampicillin is destroyed by penicillinase.

The combination of ampicillin with oxacillin is rational, because the latter, by inhibiting the activity of penicillinase, thereby reduces the destruction of ampicillin. The range of action with this combination becomes wider.

Pharmacokinetics

Suction

Cmax of active substances is reached within 0.5-1 hours after i / m administration. With intravenous administration, high concentrations are rapidly created in the blood, exceeding those with intramuscular administration.

Distribution and excretion

At repeated introductions active substances do not accumulate in the body, which makes it possible to use the drug for a long time. Excreted in the urine.

Indications

• infections respiratory tract(including bronchitis, pneumonia, bronchiectasis);
• diseases of the biliary tract (including cholangitis, cholecystitis);
• infections urinary tract and kidneys (including pyelitis, pyelonephritis, cystitis);
• infections of the skin and soft tissues (including infected wounds);
• burn disease;
• angina.

Prophylaxis postoperative complications at surgical interventions.

Prevention and treatment of infections in newborns.

Contraindications

• hypersensitivity to the components of the drug and other antibiotics from the penicillin group.

Dosage

The drug is administered intramuscularly or intravenously (jet or drip).

Single dose for adults is 0.5-1 g, the daily dose is 2-4 g.

Newborns, premature babies and children under 1 year of age the drug is prescribed in a daily dose of 100-200 mg / kg of body weight; 1-7 years old- 100 mg / kg / day; 7-14 years old- 50 mg / kg / day; adolescents over 14 years old the adult dose is prescribed.

At severe infection the indicated doses can be increased by 1.5-2 times. Daily dose administered in 3-4 doses with an interval of 6-8 hours. The duration of treatment is from 5-7 days to 3 weeks or more.

The intravenous drug is administered for 5-7 days, followed by the transition (if necessary) to the intramuscular injection.

Rules for the preparation and administration of solutions

Solutions for intramuscular administration are prepared immediately before administration by adding 2 ml of sterile water for injection to the contents of the vial.

For intravenous infusion, the drug (single dose) is dissolved in 10-15 ml of water for injection or isotonic solution and injected slowly over 2-3 minutes.

For i / v drip injection for adults the drug (single dose) is dissolved in 100-200 ml of isotonic sodium chloride solution or 5-10% dextrose solution and injected at a rate of 60-80 drops / min. For drip administration to children, a 5-10% dextrose solution is used as a solvent (30-100 ml, depending on age).

Side effects

Allergic reactions: skin rash, urticaria, Quincke's edema; rarely .

Local reactions: with intravenous administration, the development of phlebitis and periphlebitis is possible; with intramuscular injection - soreness at the injection site.

Overdose

Currently, no cases of overdose of the drug Oxamp-sodium have been reported.

Drug interactions

There is a synergism of antibacterial action when the drug is combined with bactericidal antibiotics - aminoglycosides, cephalosporins, vancomycin, rifampicin.

special instructions

If allergic reactions occur, it is necessary to stop the administration of the drug and conduct desensitizing therapy.

With the development of anaphylactic shock, the administration of epinephrine, GCS (or prednisolone), bronchodilators, blockers of histamine H 1 receptors is indicated; if necessary, perform mechanical ventilation.

Use in pediatrics

Caution should be exercised when prescribing the drug to children if the mother has an indication of hypersensitivity to penicillins. In such cases, if it is necessary to prescribe the drug Oxamp-sodium in the presence of concomitant diseases (hay fever and others allergic diseases) shows the simultaneous use of desensitizing drugs.

Pregnancy and lactation

It is possible to use the drug Oxamp-sodium during pregnancy according to indications. Stands out with breast milk in low concentrations.

Conditions of dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

The drug should be stored in a dry, dark place at room temperature. Shelf life is 2 years.

Oxamp, according to the instructions for use, is a combined antibiotic of a wide spectrum of action, aimed at stopping, both in children and in adults, a number of infectious diseases inflammatory nature. The prescription drug is classified as a penicillin antibiotic.

The drug Oxamp with its two active ingredients, ampicillin and oxacillin, is available in the following dosage forms: capsules for oral administration and powder for parenteral use.

This significantly expands the possibilities of the bactericidal effect of Oxamp, which, by suppressing the synthesis of bacterial cell walls, destroys almost all of the available pathogenic microflora.

In one oval-shaped gelatin capsule with granular filling white-yellow contains 125 milligrams of ampicillin trihydrate and 125 milligrams of oxacillin in the form of sodium salt. One blister of the drug contains 10 capsules, there are only two blisters in a cardboard box. You can also find capsules in polymer jars, packaged in 20 pieces, packed in cardboard boxes.

Oksamp injections for intravenous and intramuscular injection are more effective in relation to pathogenic microflora due to the greater saturation with the active substance.

Oxamp sodium in the form of a white-yellow porous mixture of sodium salts of ampicillin in the amount of 333.33 milligrams and 166.67 milligrams of oxacillin per 1 vial is packaged in vials of 10 milliliters each.

The vials are packed and sealed in cardboard boxes, where they contain 10 and 50 pieces.

pharmachologic effect

Oksamp medication, due to its main components, is characterized by a wide range actions.

Ampicillin in the form of semi-synthetic penicillin has a bactericidal effect and suppressing effect on the cell walls of bacteria. Shows activity against gram-positive and gram-negative microorganisms. But it lends itself to destruction by the enzyme penicillinase.

Oxacillin is also active against pathogenic microorganisms, the difference is only in its inhibitory effect on penicillinase enzymes. Thanks to this, Oxacillin reduces the breakdown of ampicillin and expands the bactericidal properties of the drug itself.

For what diseases to use

Oxamp, due to its extended spectrum of antimicrobial action, is the most effective means used in the treatment of infectious diseases of an inflammatory nature, namely:

1. With pathologies of ENT - organs caused by bacterial infection - inflammatory processes paranasal sinuses, tonsillitis, otitis media, tonsillitis.
2. With infectious lesions of the respiratory system - bronchitis, bronchiectasis, pleurisy, pneumonia.
3. At infectious diseases other localization.

Instructions for use and doses

The annotation on the use of this medication contains the methods of administration, dosage and the period of the course of the necessary therapy. The information is presented on the basis of one form or another of the release of the drug and age characteristics patients.

For children

The capsule form of this drug is indicated for admission to children, from 3 years of age to 7 years, in a daily dose of 100 milligrams per kilogram of weight. From the age of 7 to 14, the dosage of the drug is reduced and is set at the rate of 50 kilograms per kilogram of weight. After these years, the drug is prescribed in an adult dosage.

The course of treatment is 5 days, in special cases - about 2 weeks.

In a powder mixture, previously diluted with water for injection, Oxamp is used in the first months of a child's life in doses ranging from 100 to 200 milligrams per kilogram. From one year of age to seven years, the daily amount assigned medicinal product reduced at the rate of 100 milligrams per kilogram. From 7 years to 14, the optimal dosage of the drug is 50 milligrams per kilogram.

The indicated amount of medication is divided into several infusions, the course of therapy lasts about 2 weeks.

Adults

The daily dose for adults is the amount of medication in the amount of 2 grams, divided into 4 doses. In complicated situations, the permissible dose is 4 grams per day.

Oxamp powder for injection is indicated for administration to adults at a dose of 2-4 grams, divided into several doses. With a more severe infection, the dosage of the drug may be increased.

Pregnant and breastfeeding women

Actively active ingredients Oxampa have properties to easily penetrate the placenta, without causing any harm to the fetus and its vital functions. But, in any case, the drug for expectant mothers is prescribed strictly according to indications and under the supervision of doctors.

During the period breastfeeding taking the drug is not indicated. For the duration of treatment, it would be more expedient for a nursing mother to stop lactation.

Overdose

Overdose cases are rare. Symptoms of overdose with this medication include: toxic effects on nervous system, manifested - headache, tremors, convulsions, states of nausea and vomiting, weakness of the stomach. Therapy is aimed at relieving the symptoms of an overdose.

Cases in which cannot be used in treatment

The medication is prohibited for use in diseases and conditions:

1. With excessive sensitivity and individual intolerance to the components of Oksamp drugs of the penicillin group.
2. With mononucleosis of infectious etiology.
3. With lymphocytic leukemia.
4. During lactation.

The agent must be taken with caution in case of pathology in the form of renal failure and in childhood.

Side effect of treatment

In the course of treatment, patients may experience side effects caused by this tool:

1. Allergic manifestations, anaphylactic shock, redness of the skin.
2. Soreness and damage to the joints.
3. Rhinitis, conjunctivitis, febrile conditions.
4. Food pathologies, disturbances in taste, stomach weakness, vomiting.
5. Anemic conditions, a decrease in the level of leukocytes and neutrophilic granulocytes.
6. Phlebitis and soreness at the injection site.

What you need to pay attention to

With prolonged therapy with this drug, a certain control over the work of organs should be exercised. circulatory system, kidneys and liver.

Also, the prescribed treatment with this medication should be revised when the manifestations of infection intensify, which can occur when the pathogenic microflora is insensitive to the antibiotic therapy being carried out.

Allergies to penicillins may occur, especially when taken concomitantly with cephalosporins.

Use with other drugs

Compounds of this drug with bactericidal antibiotics in the form of aminoglycosides, cephalosporins, Rifampicin, Vancomycin can lead to synergism of antibacterial action.

Storage conditions and terms

It is assumed a certain temperature regime at 20 and a two-week shelf life of the ready-to-use drug out of the reach of children.

How is it released, the cost

Oxamp is a prescription drug dispensed from pharmacies as prescribed by a doctor. The cost of the drug in capsules varies within 100 rubles. Sodium oxamp can be purchased in pharmacies at a price of 500 rubles or more.

Dosage Form: & nbsppowder for solution for intramuscular injection Composition:

Ampicillin sodium (Ampicillin sodium salt sterile) (in terms of ampicillin)	133.4 mg	333.5 mg
Oxacillin sodium (Sterile oxacillin sodium salt) (in terms of oxacillin)	66.6 mg	166.5 mg

Description: Powder, white with a yellowish sheen. Hygroscopic. Pharmacotherapeutic group:Combined antibiotic (semi-synthetic penicillins) ATX: & nbsp

Combinations of penicillins

Pharmacodynamics:

Combined antibiotic combining the spectrum of action of ampicillin and oxacillin.

Ampicillin - semi-synthetic penicillin, bactericidal, acid-resistant. Active against gram-positive, non-forming penicillinase(Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae) and gram-negative(Neisseriagonorrhoeae,Neisseriameningitidis, Escherichia coli,Salmonella spp., Shigella spp., Proteus mirabilis, Haemophilus influenzae) microorganisms.

Oxacillin - penicillinase-resistant semi-synthetic antibiotic from the group of penicillins, acid-resistant; has a bactericidal effect against gram-positive microorganisms(Staphylococcus spp., Streptococcus spp., incl. Streptococcus pneumoniae, Actinimyces spp., Bacillus anthracis, Corynebacterium diphtheriae, anaerobic spore-forming rods, incl.Clostridium), gram-negative cocci(Neisseriagonorrhoeae,Neisseriameningitidis ), E.coli, Pr.mirabilis,H. influenzae, K. pneumoniae,Actinomycesspp.,Treponemaspp.

Resistant to the action of the drugPs.aeruginosa and other non-fermenting gram-negative bacteria, most strainsPr.vulgaris, Providendarettgeri, Morganellamorganii.

Pharmacokinetics:Time to reach maximum concentration (TC m ah) of both antibiotics in the blood - 0.5-1 h after i / m administration. Both antibiotics are excreted by the kidneys, partly in the bile. With repeated administrations, they do not accumulate. Indications:

Bacterial infections caused by sensitive pathogens: sinusitis, tonsillitis, otitis media; bronchitis, pneumonia; cholangitis, cholecystitis; pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, cervicitis; infections of the skin and soft tissues: erysipelas, impetigo, secondarily infected dermatoses, etc.

Prevention of postoperative complications during surgical interventions (including against the background of immunodeficiency), infections in newborns (infection of the amniotic fluid; respiratory failure of the newborn, requiring the use of resuscitation measures; the risk of aspiration pneumonia).

Severe infections (sepsis, endocarditis, meningitis, postpartum infection).

Contraindications:

Hypersensitivity Infectious mononucleosis, lymphocytic leukemia.

Carefully:

Children born to mothers with hypersensitivity to penicillins.

Pregnancy and lactation:

The use of the drug during pregnancy and lactation is possible only when the intended benefit to the mother outweighs the potential risk to the fetus.

It is excreted in breast milk, therefore, if it is necessary to prescribe the drug during lactation, breastfeeding should be discontinued.

Method of administration and dosage:

Intramuscularly.

The dosages of the drug indicated below are the sum of the dosages of ampicillin and oxacillin (sodium salts) in their fixed ratio of 2: 1 (i.e. in the dosages indicated below, 0.5 g of the drug is equal to the sum of 333.5 ampicillin + 166.5 mg oxacillin) ...

Daily dose:

- for adults and children over 14 years old- 3-6 g;

- for premature newborns and children under 1 year old- 100-200 mg / kg / day;

- 1-6 years old- 100 mg / kg / day;

- 7-14 years old- 100 mg / kg / day.

The daily dose is administered in 3-4 doses, with an interval of 6-8 hours. If necessary, these doses can be increased by 1.5-2 times.

Duration of treatment depends on the severity of the disease (from 5-10 days to 2-3 weeks, and in case of chronic processes - within several months)

For intramuscular administration, the contents of the vial (133.4 mg + 66.6 mg or 333.5 mg + 166.5 mg) are dissolved, respectively, in 2 ml or 5 ml of water for injection. The solutions are used immediately after preparation.

Side effects:

Allergic reactions: urticaria, skin flushing, Quincke's edema, rhinitis, conjunctivitis; fever, arthralgia, eosinophilia, in rare cases, anaphylactic shock; superinfection, dysbiosis, change in taste, vomiting, nausea, diarrhea, rarely pseudomembranous enterocolitis, leukopenia, neutropenia, anemia.

At the injection site, infiltration, soreness.

When signs of anaphylactic shock appear, urgent measures should be taken to remove the patient from this state: the introduction of epinephrine, GCS (or) and antihistamines, if necessary, artificial ventilation of the lungs is carried out.

Interaction:

Antacids, laxatives, food, aminoglycosides (for enteral administration) slow down and reduce absorption; increases absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins) have a synergistic effect; bacteriostatic drugs (macrolides, lincosamides, tetracyclines, sulfonamides) - antagonistic.

Increases efficiency indirect anticoagulants(suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); reduces the effectiveness of oral contraceptives, drugs, in the process of metabolism of which para-aminobenzoic acid is formed, ethinylestradiol - the risk of bleeding "breakthrough".

Diuretics, tubular secretion blockers, nonsteroidal anti-inflammatory drugs and other drugs that block tubular secretion increase the concentration of the drug in plasma, which increases the risk of toxic effects.

Allopurinol increases the risk of skin rashes.

Special instructions:

During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

The possibility of developing superinfection (due to the growth of microflora insensitive to it) requires a corresponding change in antibiotic therapy.

In patients with hypersensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

When used in high doses in patients with renal failure possible toxic effects on the central nervous system.

Release form / dosage:Powder for the preparation of a solution for intramuscular injection, 133.4 mg + 66.6 mg, 333.5 mg + 166.5. Package:

At 133.4 mg + 66.6 mg, 333.5 mg + 166.5 mg of the drug in vials with a capacity of 10 ml or 20 ml.

5 vials are placed in a blister strip packaging.

1, 5 or 10 vials or 1, 2 blisters with instructions for use are placed in a cardboard box.

50 vials with 1-5 instructions for use are placed in a cardboard box for delivery to hospitals.

Storage conditions:

In a dry, dark place at a temperature not exceeding 20 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date.

Conditions for dispensing from pharmacies: On prescription Registration number: R N002576 / 02 Registration date: 30.10.2008 Expiration date: Indefinite Marketing Authorization Holder: SINTEZ, JSC Russia Manufacturer: & nbsp Representative office: & nbspSYNTHESIS JSC joint-stock company Kurgan medical supplies and products Russia Date of information update: & nbsp 23.05.2017 Illustrated instructions

Composition and release form of the drug

Capsules white; the contents of the capsules are granules of white with a yellowish tinge.

10 pieces. - contour cell packaging (2) - cardboard packs.
20 pcs. - polymer cans (1) - cardboard packs.

pharmachologic effect

Combined antibiotic combining the spectrum of action of ampicillin and oxacillin.

Ampicillin- semi-synthetic penicillin, bactericidal, acid-resistant. Active against gram-positive, non-penicillinase-forming (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae), and gram-negative (Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Salmonella spp., Proteigella mi spp., Influenza mi spp., Influenza mi spp.

Oxacillin- penicillinase-resistant semi-synthetic antibiotic from the group of penicillins, acid-resistant; possesses a bactericidal effect against gram-positive microorganisms (Staphylococcus spp., Streptococcus spp., including Streptococcus pneumoniae, Actinimyces spp., Bacillus anthracis, Corynebacterium diphtheriae, anaerobic spore-forming rods, including coccystic bacteria) gonorrhoeae, Neisseria meningitidis), Escherichia coli, Proteus mirabilis, Haemophilus influenzae, Klebsiella pneumoniae, Actinomyces spp., Treponema spp.

Pseudomonas aeruginosa and other non-fermenting gram-negative bacteria, most strains of Proteus vulgaris, Providencia rettgeri, Morganella morganii, are resistant to the action of the combination.

Pharmacokinetics

T Cmax of both antibiotics in the blood - 0.5-1 hours after i / m administration. With intravenous administration, drug concentrations are rapidly created in the blood that exceed those with intramuscular administration.

Both antibiotics are excreted by the kidneys, partly with bile. With repeated administrations, they do not accumulate.

Indications

Bacterial infections caused by sensitive pathogens: sinusitis, tonsillitis, otitis media; bronchitis, pneumonia; cholangitis, cholecystitis; pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, cervicitis; infections of the skin and soft tissues: erysipelas, impetigo, secondarily infected dermatoses, etc.

Prevention of postoperative complications during surgical interventions (including against the background of immunodeficiency), infections in newborns (infection of the amniotic fluid; respiratory failure of the newborn, requiring the use of resuscitation measures; the risk of aspiration pneumonia).

Severe infections (sepsis, endocarditis, meningitis, postpartum infection).

Contraindications

Hypersensitivity to the components of the drug; ; lymphocytic leukemia.

Carefully

Chronic renal failure, children born to mothers with hypersensitivity to penicillins.

Dosage

Inside, a single dose for adults and children over 14 years old - 0.5-1 g, daily - 2-4 g. Children 3-7 years old - 100 mg / kg / day, 7-14 years old - 50 mg / kg / day. The duration of treatment is from 5-7 days to 2 weeks. The daily dose is divided into 4-6 doses.

In / m and / in (jet, drip), daily dose for adults and children over 14 years old - 3-6 g; for newborns, premature babies and children under 1 year old - 100-200 mg / kg / day; 1-6 years old - 100 mg / kg / day; 7-14 years old - 100 mg / kg / day. The daily dose is administered in 3-4 doses, with an interval of 6-8 hours. If necessary, the indicated doses can be increased by 1.5-2 times.

For intramuscular administration, the contents of the vial (0.2 and 0.5 g) are dissolved in 2 and 5 ml of water for injection, respectively.

For intravenous jet injection (within 2-3 minutes), a single dose is dissolved in 10-15 ml of water for injection or 0.9% solution.

For intravenous drip for adults, a single dose is dissolved in 100-200 ml of 0.9% NaCl solution or 5% dextrose solution and administered at a rate of 60-80 drops / min; children use 30-100 ml of 5-10% dextrose solution as a solvent. The intravenous drug is administered for 5-7 days, followed by a switch to intramuscular or oral administration.

Side effects

Allergic reactions: urticaria, skin hyperemia, angioedema, rhinitis, conjunctivitis; fever, arthralgia, eosinophilia, in rare cases - anaphylactic shock;

From the side digestive system: change in taste, nausea, vomiting, diarrhea, rarely - pseudomembranous enterocolitis,

From the hematopoietic system: leukopenia, neutropenia, anemia.

General reactions: superinfection, dysbiosis.

Local reactions: phlebitis and periphlebitis (with intravenous injection); with i / m - infiltration, soreness at the injection site.

Drug interactions

Antacids, glucosamine, laxatives, food, aminoglycosides(if taken orally) slow down and reduce absorption; increases absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin)- synergy of action; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides)- antagonism of action.

Increases efficiency indirect(suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); reduces the effectiveness of oral contraceptives, drugs, in the process of metabolism of which PABA is formed, ethinyl estradiol - the risk of bleeding "breakthrough".

Diuretics, tubular secretion blockers, phenylbutazone, NSAIDs and other drugs that block tubular secretion, increase the concentration of the drug in plasma, which increases the risk of developing toxic effects.

Allopurinol- increased risk of developing skin rashes.

special instructions

During the course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

The possibility of developing superinfection (due to the growth of microflora insensitive to it) requires a corresponding change in antibiotic therapy.

In patients with hypersensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

When used in high doses in patients with renal insufficiency, a toxic effect on the central nervous system is possible.

Manufacturer: JSC "Sintez" Russia

ATC code: J01CR50

Pharm group:

Release form: Liquid dosage forms... Injection.

General characteristics. Composition:

Description: powder for the preparation of a solution for intramuscular injection (or porous mass), white with a yellowish tinge, which, when dissolved, forms a transparent, almost colorless solution.

Active ingredient: 1 vial. ampicillin sodium (in terms of ampicillin) 667.0 mg; oxacillin sodium (in terms of oxacillin) 333.0 mg;

Pharmacological properties:

Combined antibacterial drug.

Oxacillin is an antibiotic from the group of semi-synthetic penicillins. Acts bactericidal, suppressing the synthesis of the bacterial cell wall. Resistant to the action of penicillinase. Active against gram-positive bacteria: Staphylococcus spp. (including those producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis; gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis; anaerobic bacteria: spore-forming rods, Actinomyces spp. Most gram-negative bacteria, rickettsia, viruses, protozoa, fungi are resistant to oxacillin.

Ampicillin is an antibiotic from the group of semi-synthetic penicillins. Acts bactericidal, suppressing the synthesis of the bacterial cell wall. Active against gram-positive bacteria: Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp. (including Enterococcus spp.), non-spore-forming bacteria (including Listeria monocytogenes); gram-negative aerobic bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Bordetella pertussis, some strains of Haemophilus influenzae.

Ampicillin is destroyed by penicillinase.

The combination of ampicillin with oxacillin is rational, because the latter, by inhibiting the activity of penicillinase, thereby reduces the destruction of ampicillin. The range of action with this combination becomes wider.

Pharmacokinetics. Suction

Cmax of active substances is achieved within 0.5-1 hours after i / m administration. With intravenous administration, high concentrations are rapidly created in the blood, exceeding those with intramuscular administration.

Distribution and excretion

With repeated injections, the active substances do not accumulate in the body, which makes it possible to use the drug for a long time. Excreted in the urine.

Indications for use:

- diseases of the biliary tract (incl.,);

- infections of the skin and soft tissues (incl.);

- angina.

Prevention of postoperative complications during surgery.

Prevention and treatment of infections in newborns.

Important! Check out the treatment

Method of administration and dosage:

Intramuscularly and intravenously (jet or drip).

The dosages of the drug indicated below are the sum of the dosages of ampicillin and oxacillin (sodium salts) in their fixed ratio of 2: 1 (i.e., in the dosages indicated below, 1 g of the drug is equal to the sum of 667.0 mg ampicillin + 333.0 mg oxacillin).

The daily dose for adults and children over 14 years old is 3-6 g; for newborns, premature babies and children under 1 year old - 100-200 mg / kg / day; 1-6 years old - 100 mg / kg / day; 7-14 years old - 50 mg / kg / day. The daily dose is administered in 3-4 injections, with an interval of 6-8 hours. If necessary, these doses can be increased by 1.5-2 times.

The duration of treatment depends on the severity of the disease (from 5-10 days to 2-3 weeks, and in case of chronic processes - within several months).

For intramuscular administration, the contents of the vial are dissolved in 10 ml of water for injection.

For intravenous jet injection (within 2-3 minutes), a single dose is dissolved in 10-15 ml of water for injection or 0.9% sodium chloride solution.

For intravenous drip for adults, a single dose is dissolved in 100-200 ml of 0.9% sodium chloride solution or 5% dextrose (glucose) solution and administered at a rate of 60-80 drops / min; children use 30-100 ml of 5-10% dextrose (glucose) solution as a solvent. The drug is administered intravenously for 5-7 days, followed by a switch to intramuscular administration.

The solutions are used immediately after preparation.

Application features:

If allergic reactions occur, it is necessary to stop the administration of the drug and conduct desensitizing therapy.

With development, the introduction of epinephrine, GCS (hydrocortisone or prednisolone), bronchodilators, blockers of histamine H1 receptors is indicated; if necessary, perform mechanical ventilation.

Use in pediatrics

Caution should be exercised when prescribing the drug to children if the mother has an indication of hypersensitivity to penicillins. In such cases, if it is necessary to prescribe the drug Oxamp-sodium in the presence of concomitant diseases ( bronchial asthma, and other allergic diseases), the simultaneous use of desensitizing drugs is shown.

Side effects:

Allergic reactions:, Quincke's edema; rarely - anaphylactic shock.

Local reactions: with intravenous administration, the development of phlebitis and periphlebitis is possible; with intramuscular injection - soreness at the injection site.

Interaction with other medicinal products:

There is a synergism of antibacterial action when the drug is combined with bactericidal antibiotics - aminoglycosides, cephalosporins, vancomycin, rifampicin.

Contraindications:

- hypersensitivity to the components of the drug and other antibiotics from the penicillin group.

Application of the drug OXAMP®-SODIUM during pregnancy and lactation
It is possible to use the drug Oxamp-sodium during pregnancy according to indications. It is excreted in breast milk in low concentrations.

Overdose:

Currently, no cases of overdose of the drug Oxamp-sodium have been reported.

Storage conditions:

List B. The drug should be stored in a dry, dark place at room temperature. Shelf life is 2 years.

Vacation conditions:

On prescription

Package:

Bottles with a volume of 10 ml (10) - cardboard boxes.
Vials with a volume of 10 ml (50) - cardboard boxes.