AMOSIN 125 Instructions for use for children. Amosyn: Instructions for use

This article allows you to familiarize yourself with the instructions for use. medicinal preparation Amosic. Presented reviews of site visitors - consumers this medicine, as well as the opinions of the doctors of specialists in the use of antibiotic amosine in their practice. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effectsmay not be stated by the manufacturer in annotations. Amone analogues in the presence of available structural analogs. Use for the treatment of angina, pneumonia, hymorite and other infectious diseases in adults, children, as well as during pregnancy and breastfeeding. The composition and interaction of the drug with alcohol.

Amosic - Antibiotic wide spectrum Actions of a group of semi-synthetic penicillins. Acts bactericidal. Inhibits transpapeptide, disrupts peptideoglycan synthesis (the support polymer of the cell wall) during the division and growth period, causes lysis bacteria. Acid-resistant.

Active in relation to aerobic gram-positive bacteria: Staphylococcus SPP. (Staphylococcus) (with the exception of penicillinase strains), Streptococcus SPP. (streptococcus); Aerobic gram-negative bacteria: Neisseria Gonorrhoeae, Neisseria Meningitidis, Bacillus Anthracis, Listeria Monocytogenes (Listeria), Helicobacter Pylori (Helicobacter), Klebsiella SPP. (Klebseyella).

Microorganisms producing penicillinase, resistant to the action of amoxicillin.

The action is developing 15-30 minutes after administration and lasts 8 hours.

Structure

Amoxicillin (in the form of trihydrate) + excipients.

Pharmacokinetics

After receiving inside Amosin quickly and almost completely (93%) absorbed from the gastrointestinal tract. Meal does not affect the absorption of the drug, does not destroy in the acidic area of \u200b\u200bthe stomach. In high concentrations, plasma, wet, bronchial secrete (in the purulent bronchial secrete, the distribution of weak), pleural and peritoneal fluid, urine, the contents of the skin blisters, the tissue of the lung, mucous membrane of the intestine, the female genital organs, the prostate gland, the liquid of the middle ear, bone , adipose tissue, bile bubble (with normal liver function), fetal tissues. With an increase in the dose of 2 times the concentration also increases by 2 times. The concentration in bile exceeds the plasma concentration of 2-4 times. IN amniotic fluid and umbilical vessels The concentration of amoxicillin is 25-30% of the plasma level in a pregnant woman. Poor penetrates through the hematostephalic barrier (GEB), when inflammation brain shells (meningitis) concentration in spinal fluid - about 20%. Binding with plasma proteins - 17%. In small quantities stand out with breast milk. Amoxicillin is partially metabolized with the formation of inactive metabolites. Amoxicillin is excreted by 50-70% with urine unchanged by canalic excretion (80%) and glomerular filtration (20%), with bile - 10-20%.

Indications

Infectious-inflammatory diseases caused by microorganisms sensitive to the drug:

• respiratory infections (including bronchitis, pneumonia);
• eNT infections (including sinusitis, pharyngitis, tonsillitis, acute average otitis);
• infection gOOD SYSTEM (including pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea);
• gynecological infections (including endometritis, cervicitis);
• infections of the gastrointestinal organs (including peritonitis, enterocolitis, abdominal typhoid, cholangitis, cholecystitis);
• infections of the skin and soft tissues (including face, impetigo, secondally infected dermatoses);
• leptospirosis;
• listeriosis;
• lyme disease (borreliosis);
• dysentery;
• salmonellosis, salmoneselosis;
• meningitis;
• endocarditis (prevention);
• sepsis.

Forms of release

250 mg capsules.

Tablets 250 mg and 500 mg.

Powder for preparing a suspension for intake of 125 mg, 250 mg and 500 mg.

Instructions for use and dosage

The drug is taken inward, before or after meals. The dosing mode is established individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.

Adults and children over 10 years old (with a mass of body more than 40 kg) are appointed 500 mg 3 times a day, with a serious course of the disease - at 0.75-1 g 3 times a day.

Children aged from 5 to 10 years are prescribed 250 mg 3 times a day, aged 2 to 5 years - 125 mg 3 times a day, under the age of 2 years - 20 mg / kg per day in 3 reception. Course treatment - 5-12 days.

Children at the age of 5 years old the drug is prescribed in the form of a suspension (the ideal children's form of the drug).

For the treatment of acute uncomplicated gonorrhea, the drug is prescribed in a dose of 3 g once; In the treatment of women, it is recommended to repeat the specified dose.

With sharp infectious diseases The gastrointestinal tract (parathy, abdominal title) and the biliary tract, with gynecological infectious diseases, adults are prescribed 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

When leptospirosis, adults are prescribed at 500-750 mg 4 times a day for 6-12 days.

At silmosenelease adults - 1.5-2 g 3 times a day for 2-4 weeks.

For the prevention of endocarditis at small surgical interventions Adults are prescribed at a dose of 3-4 g per 1 hour before the procedure. If necessary, prescribe a re-dose after 8-9 hours. Children dose are doubled.

Rules for the preparation of suspension from a monocot package

The pure glass poured a boiled and cooled water in the amount specified in the table, then the contents of one package are poured and stirred to obtain a homogeneous suspension.

• Dose in package 125 mg - the required amount of water 2.5 ml;
• dose in package 250 mg - the required amount of water is 5 ml;
• dose in package of 500 mg is the required amount of water 10 ml.

After receiving the cup, rinse with water, dry and store in a dry, clean place.

Side effect

• hives;
• skin hyperemia;
• erythema;
• angioedema edema;
• rhinitis;
• conjunctivitis;
• fever;
• pain in the joints;
• eosinophilia;
• exfoliative dermatitis;
• multiform exudative erythema;
• stevens-Johnson syndrome;
• reactions similar to serum disease;
• anaphylactic shock;
• dysbacteriosis;
• a change in taste;
• vomiting, nausea;
• diarrhea;
• stomatitis;
• glossitis;
• pseudomambranous enterocolitis;
• excitation;
• anxiety;
• insomnia;
• confusion of consciousness;
• change behavior;
• depression;
• peripheral neuropathy;
• headache;
• dizziness;
• convulsive reactions;
• interstitial nephritis;
• leukopenia, neutropenia, thrombocytopenic purpura, anemia;
• labored breathing;
• tachycardia;
• candidiasis of the vagina;
• superinfection (especially in patients with chronic diseases or reduced organism resistance).

Contraindications

• allergic diathesis;
• bronchial asthma, pollinosis;
• infectious mononucleosis;
• lympholoicosis;
• liver failure;
• the diseases of the gastrointestinal tract (especially colitis associated with the use of antibiotics);
• lactation period (breastfeeding);
• increased sensitivity to the components of the drug;
• increased sensitivity to other penicillins, cephalosporins, carbapenes;
• children's age up to 3 years (for tablets and capsules).

Application in pregnancy and breastfeeding

The use of the drug during pregnancy is possible only in cases where the intended benefit of therapy for the mother exceeds the potential risk to the fetus.

Application during lactation is contraindicated. If necessary, use during lactation should be stopped breastfeeding.

Application in children

Contraindicated children under the age of 3 years (for the form of release in the form of tablets and capsules). Children at the age of 5 years old are prescribed in the form of a suspension.

special instructions

When conducting a course of treatment with amoSin, it is necessary to monitor the state of the function of the blood formation organs, liver and kidney.

It is possible to develop superinfection due to the growth of microflora insensitive to amoxicillin, which requires an appropriate change in antibacterial therapy.

In the treatment of patients with bacteremia, the reaction of bacteriolization is rarely developed (Yarish-Gersheimer's reaction).

In patients having increased sensitivity to penicillins, crosst allergic reactions with cephalosporin antibiotics.

For treatment easy Diarrhea Against the background of the use of amosine, it should be avoided the prescription of anti-diagram preparations that reduce intestinal peristalsis; Can be used kaolin- or attapulgite-containing anti-diagracial agents. With severe diarrhea it is necessary to spend differential diagnosis and assign appropriate therapy.

Treatment should be continued 48-72 hours after disappearance clinical signs Diseases.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, if possible, use additional methods of contraception.

Medicinal interaction

Antacids, glucosamine, laxatives, food, antibiotics of aminoglycoside groups, while simultaneous use, slow down and reduce amosine absorption; ascorbic acid - increases its absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) exhibit synergism with amoxicillin; Bacteriostatic preparations (macrolides, chloramphenicol, lincoosamines, tetracyclines, sulfonamides) - antagonism.

Amoxicillin with simultaneous use increases efficiency indirect anticoagulantov (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); Reduces the effectiveness of estrogen-containing oral contraceptives, ethinyl estradiol (the risk of intermented bleeding), as well as drugs, in the process of metabolism of which para-aminobenzoic acid is formed.

The joint use of the drug amosyn with alcohol is prohibited (the hepatotoxic effect of ethanol is enhanced).

Diuretics, Allopurinol, Oxyphenbutazone, phenylbutazone, nonsteroidal anti-inflammatory agents (NSAIDs) and drugs that block the tubular secretion, while simultaneously use with amosine, reducing the channel secretion, increase the concentration of amoxicillin.

With the simultaneous use of amosine with allopurinol, the risk of skin rash is increased.

Amoxicillin, while simultaneously use, reduces the clearance and increases the toxicity of methotrexate.

Amoxicillin with simultaneous use enhances the absorption of digoxin.

Analogs of the Medicinal Amosin

Structural analogues of PO active substance:

• Amoxisar;
• Amoxicillin;
• Amoxicillin trihydrate;
• Gonoform;
• Grunamox;
• Danemoks;
• OSPAMOKS;
• Flexin Soluteab;
• Hikcotil;
• Ecobol.

In the absence of analogues of drugs on the active substance, you can follow the links below on the disease, which helps the appropriate drug, and see the analogues on therapeutic effects.

40 kg) are prescribed 500 mg 3 times a day, with a serious course of the disease - at 0.75-1 g 3 times a day. Chooms aged from 5 to 10 years are prescribed 250 mg 3 times a day, aged 2 to 5 Years - 125 mg 3 times a day, under the age of 2 years - 20 mg / kg / day in 3 reception. Course treatment - 5-12 days. Children under the age of 5 years old are prescribed in the form of a suspension. For the treatment of acute uncomplicated gonorrhea, Amosin is prescribed in a dose of 3 g once; In the treatment of women, it is recommended to repeatedly take the indicated dose. When acute infectious diseases of the gastrointestinal tract (parathy, abdominal title) and biliary tract, with gynecological infectious diseases, adults are prescribed 1.5-2 g 3 times a day or 1-1.5 g 4 times a day. When leptospirosis, adults are prescribed at 500-750 mg 4 times a day for 6-12 days. After 1.5-2 g 3 times a day for 2-4 weeks per day for 2-4 weeks. For the prevention of endocarditis at small surgical interventions, adults are prescribed in Dose 3-4 g per 1 hour before the procedure. If necessary, prescribe a re-dose after 8-9 hours. In children, the dose is doubled. Patients with impaired kidney function (CC from 15 to 40 ml / min) The interval between the receivers is increased to 12 hours, in the terminal stage of chronic renal failure (The preparation of the suspension into a clean glass is poured by boiled and cooled water in the required amount, then the contents of one package are poured and stirred to obtain a homogeneous suspension. Dose 125 mg - 2.5 ml of water, dose 250 mg - 5 ml of water, dose 500 mg - 10 ml Waters. After receiving a cup, rinse with water, dry and store in a dry, clean place. Side effects Allergic reactions: possibly - urticaria, skin hyperemia, erythema, angioedema edema, rhinitis, conjunctivitis; rarely - fever, joint pain, eosinophilic, exfoliative dermatitis, multiform exudative erythema, Stevens-Johnson syndrome, reactions similar to serum disease; In isolated cases - anaphylactic shock. From side digestive system: dysbacteriosis, change in taste, vomiting, nausea, diarrhea, stomatitis, glossite, violation of the liver function, moderate increase in the activity of hepatic transaminase; Rarely - pseudomambranous enterocolitis. From the CNS and peripheral nervous system: Excitation, anxiety, insomnia, ataxia, confusion of consciousness, change behavior, depression, peripheral neuropathy, headache, dizziness, convulsive reactions. From the urinary system: rarely - interstitial jade. From the side of the blood formation: leukopenia, neutropenia, thrombocytopenic purpura, anemia. Others: difficulty breathing, tachycardia, vaginal candidiasis, superinfection (especially in patients with chronic diseases or reduced organism resistance). Storage conditions Store in an inaccessible for children, dry, light-protected place. Powder for the preparation of suspension should be stored at a temperature not higher than 25 ° C. Special instructions when conducting a course of treatment with amoene, it is necessary to monitor the condition of the function of the blood formation organs, liver and kidneys. Perhaps the development of superinfection due to the growth of microflora insensitive to amoxicillin, which requires an appropriate change in antibacterial therapy. In the treatment of patients with bacteriamia, bacteriolization is rarely developing (Yarisha Reaction -Herksheimer). Patients having increased sensitivity to penicillins are possible cross-allergic reactions with cephalosporin antibiotics. In the treatment of light diardes, against the background of the use of amosine, avoid the purpose of antiodeary drugs that reduce intestinal peristalsis; Can be used kaolin- or attapulgite-containing anti-diagracial agents. In severe diarrhea, it is necessary to carry out differential diagnosis and appoint the appropriate therapy. There is another 48-72 hours after the disappearance of clinical signs of the disease. After that day, the use of estrogen-containing oral contraceptives and amoxicillin should, if possible, use additional methods of contraception. Leave terms without prescription "/\u003e

Amosin is a semi-synthetic preparation from the penicillin group of antibacterial spectral action.

Its exposure is manifested in the oppression of the enzyme of transpapeptidase, in violation of the stability of the cell walls, the braking of the processes of the development of pathogenic microorganisms and dividing them at the cellular level, which the final account causes lysis of the pathogenic microflora.

On this page you will find all the information about Amosyn: full instructions By applied to this drug, average prices in pharmacies, full and incomplete analogues of the drug, as well as reviews of people who have already used Amosin. Want to leave your opinion? Please write in the comments.

Clinical and Pharmacological Group

Antibiotic group of penicillins of a wide range of action that is destroyed by penicillinase.

Conditions of vacation from pharmacies

Recommended by a doctor's prescription.

Prices

How much is Amosin? average price The pharmacies are at the level of 30 rubles.

Release form and composition

Amosin is produced in several dosage forms.

Amosin gelatin capsules white color, Size number0. Content capsules - white granules. Packed in contour cells of 10 pieces.

Amosic tablets - white or almost white, flat cylindrical shape, with separation risk and chamfer. Packed in contour cells of 10 pieces.

Amosin powder for the preparation of a suspension for intake - has a white with a yellowish color color and a specific smell. The prepared suspension is obtained by white with a yellowish color shade and a specific smell. Packaged in single-bar packets of 1.5; 3 and 6 g

Pharmacological effect

Active Component medical agent Actively affects gram-negative bacteria - Neisseria MeningItidis and Listeria Monocytogenes and Bacillus Anthracis, Klebsiella SPP., Neisseria Gonorrhoeae and Helicobacter Pylori; on gram-positive staphylococcal and streptococcal bacteria. The pathogenic microflora producing peculinated peculiar to the effects of the active component of amosine.

Effect of reception therapeutic drug It manifests itself at 15-30 minutes and is preserved 8 hours. The medicine is easily and for a short time is absorbed by the tract walls, and the presence of food does not affect the rate of absorption. The maximum content of amoxicillin is achieved in the blood plasma in the first 1-2 hours. Bloodstock is conveying the acting component of the drug to the mucous membranes, bone and connective tissue, intraocular wet and liquid. The dismissal time through the kidney is on average from two to three hours and can increase in patients with impaired renal function.

Indications for use

AMOSIN antibiotic is prescribed with bacterial infections:

• Urogenital infections (, pelitis,);
• Infectious diseases digestive tract (dysentery, abdominal type,);
• Borreliosis;
• Acute infectious diseases of the upper respiratory tract;
• Acute infectious diseases of the lower respiratory tract (,);
• ENT infections ();
• Skin and soft tissue diseases (secondly infected dermatosis, impetigo,);
• Prevention of endocarditis and surgical infection.

Contraindications

Contraindications to the use of amosine are:

• Liver failure;
• Bronchial asthma and pollinosis;
• Allergic diathesis;
• Lympholoicosis;
• Infectious mononucleosis;
• Diseases of the gastrointestinal tract;
• Increased sensitivity to amoxicillin and other penicillins, as well as carbapenes and cephalosporins;
• Breastfeeding period;
• Children's age up to 3 years (for dosage form in the form of capsules and tablets).

Amosic caution is prescribed to pregnant women and patients with renal failure and bleeding in history.

Application during pregnancy and lactation

The use of the drug during pregnancy is possible only in cases where the intended benefit of therapy for the mother exceeds the potential risk to the fetus.

Application during lactation is contraindicated. If necessary, use during lactation should be stopped breastfeeding.

AMOSIN INSTRUCTIONS

In the application instructions, it is indicated that amosyn is taken inward, before or after meals. The dosing mode is established individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.

• Adults and children over 10 years old (with a mass of body\u003e 40 kg) are prescribed 500 mg 3 times / day, with a serious course of the disease - at 0.75-1 g 3 times / day.
• Children aged from 5 to 10 years are prescribed 250 mg 3 times / day, aged 2 to 5 years old - 125 mg 3 times / day, under the age of 2 years - 20 mg / kg / day in 3 reception. Course treatment - 5-12 days.
• Children at the age of 5 years old are prescribed in the form of a suspension.

For treatment of acute uncomplicated gonorrhea The drug is prescribed at a dose of 3 g once; In the treatment of women, it is recommended to repeat the specified dose.

For acute infectious diseases gasts (Parathines, abdominal typhoids) and biliary tract, with gynecological infectious diseases Adults are prescribed 1.5-2 g 3 times / day or 1-1.5 g 4 times / day.

For leptospirosis Adults are prescribed at 500-750 mg 4 times / day for 6-12 days.

For salmonellace Adults - 1.5-2 g 3 times / day for 2-4 weeks.

For endocarditis Prevention with Small Surgical Interventions Adults are prescribed at a dose of 3-4 g per 1 hour before the procedure. If necessary, prescribe a re-dose after 8-9 hours. Children dose are doubled.

In patients with impaired kidney function (CC from 15 to 40 ml / min), the interval between the techniques increases to 12 hours, in the terminal stage of chronic renal failure (QC<10 мл/мин) дозу Амосина следует уменьшить на 15-50% или увеличить интервал между приемами до 24 ч, при анурии – максимальная доза составляет 2 г/сут.

Powder for preparing suspension oral amosin

The drug is designed to prepare a suspension taken orally. Ready suspension takes before or after meals.

To prepare a suspension of powder, packaged into disposable packages, pour chilled boiled water into the cup, pour the contents of the bag and stir up to the equilibrium suspension. The amount of water is measured depending on the dose of amoxicillin in the package (to obtain a suspension containing 250 mg of amoxicillin in 5 ml of suspension). At a dose of amoxicillin in a package of 125 mg, they take 2.5 ml of drinking water, at a dose of 250 mg - 5 ml of drinking water, at a dose of 500 mg - 10 ml of drinking water. The drug should be taken immediately after the preparation of the suspension. A cup after taking the drug should be rinsed in running water and dry.

To prepare a suspension of powder, packaged in banks or bottles, 62 ml of cooled boiled water should be measured and add parts into a bottle or can. During the addition of water, a jar should be shaken or a bottle for the formation of an equilibrium suspension. The finished suspension contains 50 mg of amoxicillin in 1 ml. Before each use of the suspension should be shaken the bottle. Dosing the suspension is carried out using a measuring spoon included in the kit.

The duration of application and dose of the drug Amosin determines the doctor.

• Adults and children with a body mass of more than 40 kg (over 10 years old) are usually prescribed 500 mg of amoxicillin three times a day. In severe dose disease, the dose increases to 750-1000 mg of amoxicillin three times a day.
• Children aged from 5 to 10 years, as a rule, a 250 mg of amoxicillin reception is prescribed three times a day.
• Children aged 2 to 5 years, as a rule, a 125 mg of amoxicillin is prescribed three times a day.
• Children under 2 years old, as a rule, appoint 20 mg of amoxicillin per 1 kg of body weight three times a day.
• The average duration of therapy is from 5 to 12 days (as a rule, the drug intake is continued within 2-3 days after the disappearance of clinical manifestations of the disease).

Specific therapy schemes by Amosic drug:

Under the acute form of uncomplicated gonorrhea, adults, as a rule, are prescribed a single reception of 3000 mg of amoxicillin. Women may prescribe a re-admission of the recommended dose of amoxicillin.

1. With acute infectious diseases of the biliary tract and gastrointestinal tract, as well as gynecological diseases, adults are usually prescribed to receive 1500-2000 mg of amoxicillin three times a day or a reception of 1000-1500 mg of amoxicillin four times a day.
2. When leptospirosis, adults are usually prescribed to receive 500-750 mg of amoxicillin four times a day. The duration of receiving the drug Amosin is from 6 to 12 days.
3. At silmoseneclicity, adults are usually prescribed to receive 1500-2000 mg of amoxicillin three times a day. The duration of reception of the drug Amosin is 2-4 weeks.
4. For the prevention of endocarditis during small surgical operations, adults are usually prescribed a reception of 3000-4000 mg of amoxicillin 60 minutes before the start of operational intervention. At high risk, the development of endocarditis is prescribed a re-reception of amoxicillin after 8-9 hours after receiving the first dose. Children recommended to reduce the prophylactic doses of amoxicillin twice.

In disruption of kidney functions and clearance indicators of creatinine from 15 to 40 ml / min, it is recommended to increase the interval between amoxicilline intakes to 12 hours (at the same time, the different dose of the Amosin drug is not changed).

In violation of the kidney functions and cryatinine clearance indicators of less than 10 ml / min, amoxicillin dose should be reduced by 15-50%.

With prolonged reception of amoxicillin, it is recommended to monitor the function of the hematopoietic system, liver and kidney.

Side effects

According to the instructions for amosine, the drug reception can cause the following undesirable effects:

• From the urinary system - interstitial nephritis;
• On the part of the central and peripheral nervous system - anxiety, excitement, ataxia, insomnia, change in behavior, confusion, peripheral neuropathy, convulsive reactions, dizziness, headache;
• From the digestive system, the change in taste, nausea, vomiting, dysbacteriosis, diarrhea, glossite, stomatitis, violation of the liver function, pseudomambranous enterocolitis;
• Allergic reactions - skin hyperemia, urticaria, erythema, rhinitis, angioedema edema, conjunctivitis, joint pain, fever, exfoliative dermatitis, eosinophilic, Stevens-Johnson syndrome, multiform exudative erythema, similar to serum reaction disease, in isolated cases - anaphylactic shock;
• From the system of blood formation - neutropenia, leukopenia, anemia, thrombocytopenic purpura.

In addition, the use of amosine can cause tachycardia, superinfection, difficulty breathing and vaginal candidiasis.

Overdose

It is necessary to correctly figure out what Amosin helps, and in what cases it damages. Of course, the overdose of the drug is unpleasant and dangerous to health. In the case of receiving elevated doses of the drug in patients, vomiting, nausea, diarrhea, pain in the epigastric region may violate the water and electrolyte balance.

In the event of an overdose, the patient should rinse the stomach and assign to it enterosorbent. In the event of the development of symptoms of overdose, it is necessary to assign symptomatic therapy. It will also be appropriate to the appointment of salt laxatives, as well as conducting procedures, which support the water and electrolyte balance.

special instructions

When using amosine, it is necessary to control the condition of the kidney function, liver and blood formation organs.

1. During treatment with the drug it is possible to develop superinfection, which requires a change in antibacterial therapy.
2. In patients with bacteremia, Yarish-Gersheimer (bacteriolization reaction) may occur (reaction of bacteriolization), manifested by increasing temperature, chill, nausea, headache, tachycardia, decreased blood pressure and aggravation of the symptoms of the underlying disease.
3. With increased sensitivity to penicillins, amosine can cause cross-allergic reactions with cephalosporine antibiotics.
4. With the simultaneous use of amoxicillin and oral contraceptives containing estrogen, it is recommended to use additional methods of protection against unwanted pregnancy.
5. If there is a light diarrhea in the treatment of amoene, the prescription of drugs should be avoided, which reduce the intestinal peristalsis. To do this, you can use attapulgite or coaline-containing anti-diagracial funds. Heavy diarrhea requires differential diagnosis and appropriate treatment.

Medicinal interaction

1. Drugs that block the channel secretion are the reason for increasing the concentration of amokicillin, while using the methotrexate simultaneously, the toxicity of the latter increases.
2. With the simultaneous use of amoxicillin with glucosamines, aminoglycosides, laxatives and antacids, slow suction, when taking, together with ascorbic acid, the metabolism increases.
3. With simultaneous use with metronidazole, the nausea, vomiting, diarrhea, pain in the epigastric area is often developing.
4. In a complex with clavulanic acid, the development of cholestatic jaundice, hepatitis, multi-phoned erythema is possible.
5. Interaction with probenecide increases the serum concentration of the antibiotic and reduces its removal from the body. Amosin, like other antibacterial drugs, reduces the effectiveness of oral converse.
6. A amosine synergists are cephalosporins, aminoglycosides, rifampicin, vancomycin, cycloserine, antagonists - sulfoniamides, macrolides, tetracyclines and lincoosamides.

It is categorically contraindicated simultaneous use with disulfram. Special caution should be taken at the simultaneous use of amoxicillin and anticoagulants (this may cause prolongable time.

Dosage form

Powder for the preparation of a suspension for reception inside the white with a yellowish colors, with a specific odor; A cooked suspension of white with a yellowish color shade, with a specific smell.

Structure

amoxicillin (in the form of trihydrate) 250 mg

Auxiliary substances: polyvinylpyrrolidone (povel), glucose (dextrose), Trilon b (Dinatariya Edetat), sodium phosphate Double-sufficient (sodium hydrophosphate), sodium? - monohydrate sodium, food flavor, vanillin, sucrose.

Pharmacodynamics

The antibiotic of a wide range of a group of semi-synthetic penicillins. Acts bactericidal. Inhibits transpapeptide, disrupts peptideoglycan synthesis (the support polymer of the cell wall) during the division and growth period, causes lysis bacteria. Acid-resistant.

Active in relation to aerobic gram-positive bacteria: Staphylococcus SPP. (with the exception of penicillinase strains), Streptococcus SPP.; Aerobic gram-negative bacteria: Neisseria Gonorrhoeae, Neisseria Meningitidis, Bacillus Anthracis, Listeria Monocytogenes, Helicobacter Pylori, Klebsiella SPP.

Microorganisms producing penicillinase, resistant to the action of amoxicillin.

The action is developing 15-30 minutes after administration and lasts 8 hours.

Pharmacokinetics

Suction

After intake, amoxicillin quickly and almost completely (93%) is absorbed from the gastrointestinal tract. Meal does not affect the absorption of the drug, does not destroy in the acidic area of \u200b\u200bthe stomach. The Cmax of the active substance in the plasma is observed after 1-2 hours. When taking inside at a dose of 125 mg and 250 mg Cmax in the blood plasma is 1.5-3 μg / ml and 3.5-5 μg / ml, respectively.

Distribution

It has a large VD: in high concentrations found in plasma, wet, bronchial secrete (in the purulent bronchial secrete, the distribution of weak), pleural and peritoneal fluid, urine, the contents of the skin blisters, the tissue of the lung, mucous membrane of the intestine, female genital organs, prostate gland, liquid Middle ear, bone, adipose tissue, bustling bubble (with normal liver function), fetal tissues. With an increase in the dose of 2 times the concentration also increases by 2 times. The concentration in bile exceeds the plasma concentration of 2-4 times. In amniotic fluid and umbilical vessels, amoxicillin concentration - 25-30% of the plasma level in a pregnant woman. Poor penetrates through the BGB, with inflammation of the brain shells (meningitis), the concentration in the spinal fluid is about 20%.

Binding with plasma proteins - 17%.

In small quantities stands out with breast milk.

Metabolism

Amoxicillin is partially metabolized with the formation of inactive metabolites.

Election

The amoxicillin T1 / 2 is 1-1.5 hours. Amoxicillin is derived by 50-70% with urine unchanged by canalis excretion (80%) and glomerular filtration (20%), with bile - 10-20%.

Pharmacokinetics in special clinical cases

The premature, newborn and children under 6 months T1 / 2 is 3-4 hours.

When the kidney function is violated (KK? 15 ml / min) T1 / 2 amoxicillin increases to 8.5 hours.

Amoxicilline is removed during hemodialysis.

Side effects

Allergic reactions: possibly - urticaria, skin hyperemia, erythema, angioedema edema, rhinitis, conjunctivitis; rarely - fever, joint pain, eosinophilic, exfoliative dermatitis, multiform exudative erythema, Stevens-Johnson syndrome, reactions similar to serum disease; In isolated cases - anaphylactic shock.

From the digestive system: dysbacteriosis, change in taste, vomiting, nausea, diarrhea, stomatitis, glossitis, violation of the liver function, moderate increase in the activity of hepatic transaminases; Rarely - pseudomambranous enterocolitis.

From the CNS and the peripheral nervous system: excitation, anxiety, insomnia, ataxia, confusion of consciousness, change behavior, depression, peripheral neuropathy, headache, dizziness, convulsive reactions.

From the urinary system: rarely - interstitial jade.

From the side of the blood formation: leukopenia, neutropenia, thrombocytopenic purpura, anemia.

Others: difficulty breathing, tachycardia, vaginal candidiasis, superinfection (especially in patients with chronic diseases or reduced organism resistance).

Features of sale

prescription

Special conditions

When conducting a course of treatment with amoSin, it is necessary to monitor the state of the function of the blood formation organs, liver and kidney.

It is possible to develop superinfection due to the growth of microflora insensitive to amoxicillin, which requires an appropriate change in antibacterial therapy.

In the treatment of patients with bacteremia, the reaction of bacteriolization is rarely developed (Yarish-Gersheimer's reaction).

In patients having increased sensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

In the treatment of light diarrhea, against the background of the use of amosine, the appointment of antiodeary drugs, which reduce the intestinal peristalsis should be avoided; Can be used kaolin- or attapulgite-containing anti-diagracial agents. With severe diarrhea, it is necessary to carry out differential diagnostics and assign appropriate therapy.

Treatment should be continued 48-72 hours after the disappearance of clinical signs of the disease.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, if possible, use additional methods of contraception.

Indications

Infectious-inflammatory diseases caused by microorganisms sensitive to the drug:

Respiratory infections (including bronchitis, pneumonia);

ENT infections (including sinusitis, pharyngitis, tonsillitis, acute average otitis);

Infections of the urogenital system (including pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea);

Gynecological infections (including endometritis, cervicitis);

Infections of the gastrointestinal organs (including peritonitis, enterocolitis, abdominal typhoid, cholangitis, cholecystitis);

Infections of the skin and soft tissues (including face, impetigo, secondally infected dermatoses);

Leptospirosis;

Listeriosis;

Lyme disease (borreliosis);

Dysentery;

Salmonellosis, salmoneselosis;

Meningitis;

Endocarditis (prevention);

Sepsis.

Contraindications

allergic diathesis;

Bronchial asthma, pollinosis;

Infectious mononucleosis;

Lympholoicosis;

Liver failure;

The diseases of the gastrointestinal tract (especially colitis associated with the use of antibiotics);

Lactation period (breastfeeding);

Increased sensitivity to the components of the drug;

Increased sensitivity to other penicillins, cephalosporins, carbapenes;

Children's age up to 3 years (for tablets and capsules).

With caution, the drug should be prescribed during pregnancy, renal failure, as well as when indicating a history of bleeding.

Medicinal interaction

Antacids, glucosamine, laxatives, food, antibiotics of the aminoglycoside group, while simultaneous use, slow down and reduce amoxicillin absorption; Ascorbic acid - increases its absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) exhibit synergism with amoxicillin; Bacteriostatic preparations (macrolides, chloramphenicol, lincoosamides, tetracyclines, sulfonamides) - antagonism.

Amoxicillin, while simultaneously use, increases the efficiency of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); Reduces the effectiveness of estrogen-containing oral contraceptives, ethinyl estradiol (the risk of intermented bleeding), as well as drugs, in the process of metabolism of which a para-aminobenzoic acid is formed.

When the child is very sick, only a competent doctor can help. If you are lucky, the child is separated by several doses of antiviral drugs. If the doctor arises at least the slightest concerns about possible complications, most likely, he will appoint an antibiotic.

Recently, according to the Ministry of Health, seasonal "sores" mutate and leak harder, especially in children aged 2-3 years. It is at this time that the kids begin to attend kindergarten, actively know the world, contact with peers. And there - grateful soil for mutual exchange of bacteria. As a result, mom has to go to hospital with enviable regularity.

What diseases lie most often a little man? Plot pediatricians know exactly this question. The most common among children in winter and in the offseason bronchitis, angina, pharyngitis, different forms of otites, tonsillitis. If the child rolled on an ice hill or rink, another trouble can happen - the supercooling often causes inflammation of the urogenital system. The conclusion of the doctor then sounds differently - cystitis, pyelonephritis. Often, the kids suffer from intestinal diseases (they usually "bring" from the kindergarten). There is an exit. In all these cases, the modern AMOSIN antibiotic is effectively helped.

What it is?

Let's try to tell about it in a simple language. If your child is reluctant to take this drug now, read it, and then tell him the fairy tale about the courageous defender of all the sick guys amosine. Believe me, to persuade the kid to take another dose no longer have to. He himself will gladly drink medicine.

So, "amosin 250" is a modern antibiotic of a wide range of action. It has close related relations with semi-synthetic penicillins. It works like a riot police - quickly and decisively. Active substance - amoxicillin. His goal is malicious microbes of various origin. The drug enters the body, after 15-20 minutes penetrates into a malicious bacterium cell and reduces the speed of all chemical processes that flow in it. Destroys the structure, membrane, enzymes.

The "angry" cell also wants to live, it begins to actively resist and as a result spends the last forces. Amosin is adamant. Its action continues up to 8 hours.Some "enemy" cells are trying to influence it with acid. But the valiant antibiotic is stable to it. Therefore, it wins 100% of cases. From the body is excreted pretty quickly, with the formation of inactive metabolites. This means that decay products are not toxic.

In addition to Otitis, bronchitis and the masses of other colds, the tool successfully copes with such "serious" rivals as samorite, salmonellosis and meningitis. Running with skin infections. Most often, the drug is recommended for angina, since this disease causes bacteria of various species.

Instructions for use

Amosic 250 is different: powder, granules. There is a solution for intramuscular and intravenous application. But the children most often are prescribed in tablets. Todders aged 2-3 years are usually recommended to take an antibiotic in the form of a suspension. It is easy to drink, she is pleased with the taste and smell due to vanillina added by the manufacturer in the main composition. In the form of the Syrope "Amosin" is not available.

The dosage is determined by the doctor. It depends on the age of the child. Amosin 250 can be given even a newborn from the first days of life.

Suspension for children to parents will have to be prepared independently. For this, the powder is simply added to the cooled boiled water. "AMOSIN 125" (the drug with an active active substance in the amount of 125 mg) should be diluted in 2.5 ml. water. For a means of 250 mg, it will take 5 ml of water, respectively. For 500 mg - 10 ml. liquids.

Dosage and reception schedule is usually like that.

• Baby from birth to 2 years:three times a day. Total day dosage 20 mg of suspension per kilogram of patient weight.
• Reached up to 5 years inclusive can take 125 mg. Suspension three times a day.
• Guys from 5 to 10 years:three times a day 250 mg.
• Schoolchildren older than 10 years 500 mg "Amosine" also three times a day.

Tablets and drug capsules do not give children up to 2 years!

Sometimes "Amosin" is prescribed children for the prevention of endocarditis or surgical infection. In this case, doctors recommend starting from half an adult dose.

Contraindications

Be sure to inform the doctor appointing your child "Amosin" if the baby has at least one of these diseases:

• allergic diathesis;
• flowering allergies (pollinosis);
• bronchial asthma;
• liver failure;
• kidney disease;
• frequently repetitive bleeding.

All these diagnoses are strict contraindications to the reception of this antibiotic.

The drug cannot be taken also to children who have ever acted with colitis or suffer allergies on antibiotics.

Side effects

Do not forget that, like any powerful antibiotic, the tool may cause side effects.The instructions for use describes such symptoms:

• disorders of the gastrointestinal tract;
• nausea;
• allergic runny nose;
• the appearance of rash and itching;
• dyspnea, sleep impairment, depression of the central nervous system, the fosterness of the child.

If your son or daughter has at least something from the listed, be sure to report this to Dr. - it will adjust the dosage and will give the necessary recommendations.

Overdose

If it happened that the child accepted the dose of the drug exceeding the prescribed by the doctor, watch him carefully. "Copy help" should be caused by the appearance of such symptoms as nausea, severe vomiting, abdominal pain, dizziness. Only "Emergencies" experts will be able to help in this situation, because the powerful antibiotic acts quickly, and there is simply no antidote to him. Doctors promptly wet the stomach with brine and remove intoxication of the body. In this case, self-treatment in this case is extremely dangerous.

Price

Amosin is more than available. The average cost in Russian pharmacies is about 70 rubles (sachets for the preparation of suspension), 27-40 rubles (pills). A little more than 60 rubles is a drug in capsules. Prices in different regions of the country and pharmaceutical networks may differ, the truth is slightly.

Shelf life and storage conditions

The drug should be stored in a place protected from moisture and direct sunlight, at a temperature not higher than + 25 ° C and not lower than + 15 ° C, not more than 2 years from the date of manufacture. The drug is released strictly by recipe.

Analogs

AMOSIN 250 - antibiotic domestic production. Manufacturer - Pharmaceutical Company Synthesis AKO OJSC (Kurgan region).

The situation with the analogs is quite interesting. Usually the original drug is more expensive than analogues. But here it's the opposite. Preparations with similar action are as follows:

Flexin SOLUTAB. Produced in Holland. Packing tablets (20 pieces) costs more than 300 rubles.

Augmenten . Antibiotic bacterial action from England. Packing tablets (20 pieces) costs more than 250 rubles. By the way, somewhere "Augmenten" love to prescribe pediatricians to their patients. Parents not to overpay, it makes sense to clarify the doctor if it is possible to replace it with our original Amosin, which is almost 5 times cheaper.

Amoxiclav.. Another drug is similar. Produced in Slovenia. It is more expensive than other analogues. For packaging of 14 tablets will have to give 250 rubles.