Xilomeazoline - instructions for use. Xylometazoline - instruction, application, indications, contraindications, action, side effects, analogues, dosage, composition of xylometazoline Children's instructions for use

Xylometazoline is a drug that is included in a group of vasoconstrictor drugs intended for use in LOR-Practice.

What is the drug xylomezoline composition and form of release?

The active ingredient drug is represented by xylometazoline hydrochloride, the amount of which is 500 micrograms or 1 milligram. Auxiliary components Means: sodium hydrophosphate, Dinatari Edetat, Benzalconium chloride, potassium dihydrophosphate, sodium chloride and water for injection.

The Xilomezoline preparation is produced in the form of a transparent solution for instillation into the nose with a concentration of the active substance of 0.05 and 0.1 milligrams. Permissible presence of a slightly yellowish shade. It comes in plastic bottles of 25, 15, 10 milliliters equipped with a pump-dispenser. Included in the list of drugs that can be purchased without a recipe.

What is the xylometazoline agent action?

Xylometazoline is among the alpha adrenostimulants, it has a vasoconstrictive effect. Used only in otorinolaryngological practice, since it is able to effectively eliminate the manifestations of rhinitis, and also restores nasal breathing.

Xilomezoline, acting on its specific receptors, leads to an increase in the tone of smooth muscle fibers, located in the wall of the nose cavity mucosa vessels. This circumstance leads to a decrease in waste, and the liberation of the upper respiratory tractWhat contributes to the facilitation of the patient's condition.

In addition, local use of the drug contributes to the suppression of the secretory activity of the nasal cavity epithelium, and this leads to a decrease in the amount of discharges of the mucus, which further contributes to the release of nasal respiration.

The effect of the xylometazoline drug begins a few minutes after use. Duration therapeutic effect does not exceed a few hours.

Despite the ambiguous attitude towards the vasoconductive drugs, the use of such funds is still recommended by most professionals. Long-term congestion of nasal strokes may result in the appearance of the complications of the disease in the form of a hymorite and so on.

It is important to note that the use of vesseloring drugs should be rigidly limited in time. With prolonged and uncontrolled application, the probability of the development of atrophic rhinitis is dramatically increasing.

The coefficient of system action is extremely small. When used within the framework of recommended dosages, the presence of xylometazoline in blood plasma is almost impossible to determine. By virtue of this system side effects There are very rare.

What are the Xilomeazolin drug testimony for use?

The use of xylomezoline vasoconstrictor means is shown in the presence of the following states:

Infectious rhinitis;
Allergic rhinitis;
Sinusitis;
Medium otitis.

In addition, the drug is used during polynosis.

What is Xilomezoline contraindications for use?

Using Xilomeazolin Medication Instructions for use prohibits in the presence of the states below:

Individual intolerance;
Arterial hypertension;
Glaucoma;
Pronounced atherosclerosis;
Thyrotoxicosis;
Operations on the shells of the brain in the recent past;
Age less than 6 years;
The need for the use of tricyclic antidepressants and Mao inhibitors.

Relative contraindications: angina, prostate adenoma, diabetes, Pregnancy and lactation.

What are xylometazoline application and dosage?

The duration of use should not exceed 5-s day. With the ineffectiveness of treatment it is very important to visit the specialist and appoint comprehensive therapycomprising medication and physiotherapy treatment.

Overdose from xylomezoline

Symptoms for overdose The following: dry and burning in the nose, tachycardia, increase arterial pressure, as well as headache. Treatment: Cancel Xilomezolina, symptomatic treatment.

What are the side effects from xylometazoline?

With a long and uncontrolled application of the drug, the following negative consequences are possible: dryness of the mucous membrane of the nasal cavity, violation of the heart rhythm, insomnia, vision disorders, depression, increasing the elap of the nasal cavity mucosa, as well as the increase in blood pressure, in addition, paresthesias in the limbs.

special instructions

It is very important, before using the drug to clean the nasal moves. Otherwise, the effectiveness of the medication can be significantly reduced. In chronic rhinitis, the use of the medication is not recommended.

How to replace xylometazoline, what analogues to use?

Xylometazoline Rusfor, for Nose, Sanorin-Ksilo, Nose-Balsam, Influenza Reno, Rinomarus, Inflinur, Rinonorm, Rinonorm, Olint, Rinotaiss, Xylene, Xylometazoline Buffus, Tizin Xilan, Xylometazolin-Betaleg, Ximeline Eco, Ksicogen, Ksemelin, Snoop, Nazolin, Espazoline, Rimaris, Rhinostop, Galazoline, Noshozyin, Nose-Balsam, forns, Xylometazoline Hydrochloride, Brizolin, as well as pharmalisoline, Super Nose belongs to the analogues.

Conclusion

The duration of treatment, as well as the dosage must be strictly limited. It is categorically unacceptable for the use of the drug over weekly.

The patient will independently be studied instructions for the use of the prescribed drug. Be healthy!

Xylometazoline is a local vasoconstrictor drug, designed to treat a runny nose and eliminating the nasal congestion. It is the active substance of many popular droplets and sprays from a cold (see analogs).

The vasoconductive effect is ensured by stimulating alpha-adrenoreceptors in the nasal mucosa - this leads to an increase in the tone of the walls of peripheral blood vessels. As a result, it is stopped inflammatory processeliminated swelling and restores breathing.

The drug is produced in the form of 0.05% and 0.1% of nasal droplets, 0.05% and 0.1% nasal spray.

Xylometazoline begins to act in 1-3 minutes, and the action lasts up to 8-10 hours. For local application It is practically not absorbed, plasma concentrations are so small that they cannot be determined by modern analytical methods.

Indications for use

What does xylometazoline help from? According to the instructions, the drug is prescribed for short-term symptomatic treatment:

• Acute allergic rhinitis;
• Sinusitis;
• Orz with phenomena of rhinitis;
• Halfline;
• Middle Otita (as an aid to remove the edema of the nasal mucosa).

Additionally, it is used in preparation for diagnostic manipulations and procedures in nasal moves.

Instructions for use xylometazoline, dosage drops and spray

Drops for the nose xylometazoline are used only intranasally (in nasal moves). The instruction recommends dosage:

• Children from 6 years old and adults - from 2 to 3 drops (0.1%) \\ 3 times a day;
• Children from 2 to 6 years old - from 1 to 2 drops (0.05%) \\ 2 times a day;

Pay attention to the dosage of drops 0.1% \\ 0.05%.

Xilomezolin spray

• Spray 0.1% (children from 6 years and adults) - 1 injection \\ from 2 to 3 times a day;
• Spray 0.05% (children 2 - 6 years old) - 1 injection \\ from 1 to 2 times a day;
• The course is applied - no more than 7 days (addiction is developing).

If within a week of improving the state is not observed, you should consult a doctor to clarify the diagnosis and appointment of appropriate treatment.

special instructions

People with chronic rheore should limit the use of the drug due to increased risk of atrophy of the nasal mucosa.

Side effects

The instruction warns the possibility of developing the following side effects when appointing drops or spray xylometazoline:

• Burning in the nose and throat;
• Mucous irritation;
• Dryness mucosa dry;
• Sneezing;
• Headache;
• Dizziness;
• Swelling of the nasal mucosa;
• Insomnia;
• Heart rate violation;
• Tachycardia;
• Increased blood pressure;
• Increased excitability;
• Vision impairment;
• Vomiting;
• Depression.

Contraindications

Contraindicated to appoint Xylometazoline in the following cases:

• Pronounced atherosclerosis;
• Glaucoma;
• Thyrotoxicosis;
• Tachycardia;
• Arterial hypertension;
• Surgical interventions on brain shells a history of
• Atrophic rhinitis;
• Simultaneous use with tricyclic antidepressants or monoaminoxidase inhibitors;
• Children's age up to 2 years old, up to 6 years (for droplets and spray 0.1%).

Apply with caution:

• Ischemic heart disease (wall-class angina of the III-IV functional class);
• Diabetes;
• BPH;
• Pregnancy and breastfeeding;
• Children's age up to 2 years (for drops of 0.05%);

Overdose

Symptoms of overdose - expansion of pupils, drowsiness, cyanosis, nausea, vomiting, fever, tachycardia, arrhythmia, heart stop, bradycardia, respiratory impairment, hypertension, pulmonary edema, mental disorders.

In severe cases, coma is possible.

With random reception inside, wash the stomach and reception of sorbents. Artificial respiration may be required, drugs to reduce blood pressure, antipyretic and anticonvulsants.

Kysilomezoline analogues, price in pharmacies

If necessary, replace xylometazoline can be on analogue active substance - These are drugs:

1. Dr. Tasse Rinotaiss;
2. Nostin;
3. Rinorus;
4. Espazolin.

Choosing analogues It is important to understand that the instructions for the use of xylomezoline, the price and reviews are not applied to the drugs of similar effects. It is important to obtain a doctor's advice and not to produce an independent replacement of the drug.

Price in Russian pharmacies: Xylometazoline Spray 0.05% 10 ml - from 53 to 80 rubles, the cost of spray spray 0.05% 10 ml - from 57 to 81 rubles, the drops for the nose are currently not on sale, according to 634 pharmacies.

Store at temperatures from 0 to 25 ° C in a dry, light-protected place. Take care of children. Shelf life - 3 years.

Conditions for leave from pharmacies - without a recipe.

Difference Xilomezoline and Oxymetazolina

Both drugs relate to the group of imidazolins operating on α1 and 2-adrenoreceptors, and for a simple consumer there is no significant difference between them. Xylometazoline and oxymetazoline are vasoconducting means and cause addictive during long-term use.

The only difference is the time of action, oxymetazoline is valid for several hours longer than xylometazoline, but its action is not developing immediately, but within 10-15 minutes. Preparations based on it:, Noksprey, etc.

Currently, there are a large number of drugs from a cold. Among them separate attention He deserves xylometazoline, as it has a pronounced effect, however, as in the case of other drugs, you need to explore the instructions for use. It is also important for advice at the attending physician.

The medication is produced in the form of spray, as well as drops for the nose. Consider the main components that are part of:

1. Xylometazoline hydrochloride (0.5 milligrams).
2. Benzalconium chloride (0.15 milligrams).
3. Dinatari Edetat (0.47 milligrams).
4. Potassium dihydrophosphate (3.63 milligrams).
5. Sodium dihydrophosphate dihydrate (3.54 milligrams).
6. Sodium chloride (9 milligrams).

Also in the composition, along with xylometazoline, there is purified water. Spray is produced in bottles with dispensers of 10 and 20 milliliters.

The drug may cause human organism Side effects, which is why, before applying, consultation is required with a specialist.

pharmachologic effect

This medication has a vasoconductive effect. Due to the narrowing of large and small vessels, a decrease in edema and hyperemia is performed. If the drug is used for rhinitis, then nasal breathing is significantly improved.

Indications for use

• availability acute form allergic rhinitis;
• medium otitis;
• polleoz and sinusitis.

Also prescribed medicinal composition In the case of patient preparations for certain diagnostic procedures, conducted with the nasal sinuses.

With normal nasal congestion, this composition is not prescribed, as other drugs are used.

Contraindications and side effects

• clotted glaucoma;
• pronounced atherosclerosis;
• there were surgical interventions in brain tissue;
• present increased sensitivity to components;
• there is an individual intolerance to the drug;
• the presence of tachycardia and arterial hypertension.

When treating this medicine side effects Rarely manifest. Among them are highlighted swelling of the mucous membrane, an increase in blood pressure, interruptions in the heart rhythm, headaches, dizziness, and allergic reactions, itching, temperature rise, rash.

In the manifestation of side effects, it is necessary to immediately stop using the drug, as well as consult with a specialist.

Instructions for use

Instructions for use of droplets in the nose contains the following recommendations:

• carry out therapy within 7-14 days;
• dose is appointed by a doctor, depending on age;
• for children aged two to seven years, gel is prescribed;
• children in treatment should be observed by the doctor.

With manifestation cold illnessIf crusts are formed in the sinuses, the drug composition in the form of a gel should be used.

Xilomezoline during pregnancy

During pregnancy, as well as in the period breastfeedingThe direct observation of the doctor is required. Dosage, as well as the frequency of drug use, are appointed by a specialist. These periods takes into account the effect of the drug, as well as the risk of harming the woman and her child.

In order not to encounter during pregnancy with complications, it is recommended to replace xylomezoline to more secure drugs.

Overdose

Currently, an overdose of drugs has not been detected. So as not to harm the body, it is not recommended to take drug Treatment for a long time (a longer period than a therapeutic course).

Medicinal interaction

Terms of sale

The medication is located in a free sale. It can be found in any pharmacy, in addition, the acquisition is not required for the presence of a recipe.

Terms and Storage Terms

Medicinal composition requires to be stored under the following conditions:

• at a temperature not exceeding 25 degrees;
• where there is no natural light;
• no access for children.

The medication can be stored for three years, after which it should be rid of it and acquire a new spray.

Analogs

If necessary, xylometazoline can be replaced with the following drugs:

1. Eucabal.
2. Tizin.
3. Rininkles.
4. Xilomeazole.
5. Ksinos.

Before you independently find a replacement with a drug, you need to get a recommendation from a specialist.

Xylometazoline is a vesseloring agent intended for local use in ENT diseases.

Release form and composition

The preparation is produced in the form of 0.05% and 0.1% of nasal droplets, 0.05% and 0.1% eucalyptus nasal spray.

Drops are a transparent, colorless or with a yellowish tinge solution, 1 ml of which contains:

• Such auxiliary components like: sodium hydrophosphate, dinatarium Edetat, sodium chloride, potassium dihydrophosphate, chloride benzalconium, purified water.

The drops in polymer bottles of 10, 15 and 25 ml with a dispenser are realized.

Spray is a colorless or slightly painted liquid with a characteristic eucalyptus odor, 1 ml of which contains:

• 500 μg or 1 mg of xylometazoline hydrochloride;
• Such auxiliary components as: sodium hydrophosphate dodecahydrate, dehydrate dihydrate dihydrate, benzalconium chloride, potassium dihydrophosphate, sorbitol, macrogol glycerylhydroxyish, sodium chloride, glycerol, eucalyptus oil, purified water.

Spray in bottles with a sprayer of 10 and 20 ml is implemented.

Indications for the use of xylometazoline

As stated in the instructions for xylometazoline - this is the anti-ethnic agent is intended for short-term symptomatic treatment:

• Acute allergic rhinitis;
• Sinusitis;
• Orz with phenomena of rhinitis;
• Halfline;
• Middle Otita (as an aid to remove the edema of the nasal mucosa).

In addition, Xilomezoline, according to the instructions, are prescribed to patients when preparing for diagnostic manipulations and nasal procedures.

Contraindications

According to annotations to this medicine, the use of xylometazoline is contraindicated:

• Patients with glaucoma;
• With expressed atherosclerosis;
• With closed-coronal glaucoma;
• With tachycardia;
• In atrophically ritic;
• With thyrotoxicosis;
• Patients undergoing surgical intervention on cerebral shells;
• Children under 6 years old in the form of a solution of 0.1%;
• In the presence of hypersensitivity to xylometazoline hydrochloride or any subsidiary component.

Prescribed Xilomeazoline, but according to strict testimony and under the permanent supervision of the doctor:

• Pregnant women;
• During angina;
• Patients with prostate hyperplasia;
• Kids up to 2 years as a 0.05% solution;
• During lactation;
• Sick diabetes.

Method of application and dosage xylometazoline

Nasal drops at a concentration of 0.1% are prescribed to children from 6 years of age and adults for 2-3 cap. In every nasal stroke three times a day. Children under 6 years old can only be used 0.05% solution. It is prescribed 1-2 drops in every nasal move twice a day.

Spray nasal at a concentration of 0.1% is prescribed to adults and children from 6 years old by one injection into each nasal stroke 2-3 times a day. Kids 2-6 years old - 0.05% Spray one injection 1-2 times a day.

Like any vesseloring agent, xylometazoline is not recommended to use more than 7 days in a row, because It can cause addictive. If the state improvements during this time is not observed, you should consult a doctor to clarify the diagnosis and the appointment of appropriate treatment.

Side effects of Xilomezolina

Numerous patient reviews that have undergone treatment with the use of xylomezoline, indicate that this drug is moved well and, subject to the adverse effects recommended by the doctor, does not provide.

Nevertheless, it should be noted that in individual cases it is possible: an increase in blood pressure, a violation of cardiac rhythm, vision, sleep disorder, headache, vomiting.

With prolonged and / or frequent use of xylomezoline, there is a burning sensation, hypersecretion, irritation, tingling and dryness of the nasal mucosa, as well as the depressive state. It is impossible to note that the last phenomenon arises in extremely rare cases if the patient applies a drug in high doses over a long period.

Overdose drug It is fraught with the appearance of side effects or enhanced existing.

In case of random reception of the drug inside (more often in children), it may occur: arrhythmia, tachycardia, confusion, an increase in blood pressure, a decrease in body temperature, a shock-like hypotension, bradycardia, drowsiness, apnea and coma. Therefore, in this case, it should be immediately called an ambulance.

special instructions

For a long period, for example, chronic rheintit is not recommended to use any vesseloring agent, since there is a risk of adding addiction to the medicine, reduce the sensitivity of the vessels to active substance or secondary extension of vessels, which provokes the swelling of the nasal mucosa.

Before use of xylomezoline, the nasal moves from crust and mucus should be cleaned, this will allow the drug to affect the mucous membrane, which will improve the therapeutic effect.

Xylometazoline hydrochloride is pharmaceutically incompatible with tricyclic antidepressants and Mao inhibitors. And when it is collaborated with non-selective inhibitors reverse grip Monoamins are possible the development of hypertension.

Analogs of xylometazoline

The pharmaceutical industry offers for sale a lot of xylometazoline analogues, in particular: Galazoline, tonted, influenza, xylene, ximelin, nosenel, rinonorm, deryvin, rhinostop, pharmaceutical, tizin, sanarin, Salor, Espazolin.

Terms and conditions of storage

Xylometazoline - a drug of a non-prescription vacation. The term of its shelf life is 3 years, subject to the storage rules recommended by the manufacturer, a dry and cool place, where the air temperature does not exceed 15 ºС. After opening the drop packing, you need to use within 28 days.

In 1 ml of drops 0.05% and 0.1% xylometazolina 500 μg and 1 mg, respectively. Sodium hydrophosphate, potassium dihydrophosphate, sodium chloride, benzalconium chloride as auxiliary components.

In 1 ml spray 0.05% and 0.1% xylometazolina 500 μg and 1 mg, respectively. Sodium Hydrophosphate, Benzalconium Chloride, Edetata Dihydrate Dihydrate Dihydrate, Kalia Dihydrophosphate, Eucalyptus Oil, Sodium Chloride, Macroogol Glycerylhydroxy Systemarate, Sorbitol, Water as auxiliary components.

In 1 g gel xylometazolina 1 mg. , , ammonia solution, propylene glycol ethanol, methylparaben, propylparaben, water as auxiliary components.

Form release

Drops at a concentration of 0.05% and 0.1%, nasal gel 0.1%, spray 0.05% and 0.1%.

pharmachologic effect

Anti-progenivistic (Local antino , vasoconducting ).

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Xylometazoline - derivative imidazolina . Stimulates α1 and 2-adrenoreceptors of blood vessels of the nasopharyngeal mucosa. As a result, they are narrowing blood vesselsThe hyperemia, mucous and nasal separated from the nose decreases. As a result, breathing through the nose with, allergic conditions and diseases of the incomplete sinus . Spray additionally contains eucalyptus oil, which has anti-inflammatory and antibacterial effects, which favorably affects the reduction of the edema of the nasal mucosa. The action is manifested in 10-15 minutes and lasts 8 -10 hours.

Pharmacokinetics

The study of the pharmacokinetics of the drug in man was not conducted. Sometimes under the local application, suction is sufficient to appear systemic effects.

Indications for use

• rhinitis different etiology ( , viral, traumatic, bacterial);
• and evstachitis ;
• to facilitate the departing of the secret sinusite ;
• to facilitate the diagnostic manipulations in the nasal strokes.

Contraindications

• hypertonic disease ;
• pronounced
• thyrotoxicosis;
• chronic rhinitis and atrophic ;
• sensitization to the drug and elevated sensitivity ;

Caution is used at. Pediatrics are not used by a concentration of 0.1%.

Side effects

• burning in the nose and throat;
• irritation mucous
• dryness nasopharynx mucosa;
• sneezing ;
• edema nasal mucosa;
• heart rate violation;
• tachycardia ;
• raising;
• increased excitability ;
• vision impairment;
• vomot ;

Instructions for the use of xylomezoline (method and dosage)

All forms of the drug are used intranasally.

Xylometazoline drops in the nose 0.1% are used in adults 1-2 drops in every turn three times a day.

Spray 0.1% is used in adults by 1 pressing (which corresponds to 0.1 mg) in each turn. Applikator is introduced, keeping vertical position Flacon, and make injection three times a day after 8-10 hours.

Gel 0.1% is applied by adults for 2-3 drops of gel 3 times a day.

Given the possibility of systemic adsorption and appearance adverse ReactionsThe instruction on the use of xylomezoline should be strictly observed. Apply the drug in any form of release no more than 3-5 days. It should not be used for a long time and in chronic rhine. If crusts appear in the nose, it is better to use a drug in the form of a gel. The subsequent dose of the subsequent dose does not double.

Overdose

Manifests symptoms: expansion of pupils, nausea, vomiting, tachycardia, arrhythmia, heart stop, respiratory impairment, hypertension, lung edema, mental disorders. Drowsiness , bradycardia, apnea And indicate the suppression of the CNS function.

Treatment: stomach wash, applying sorbents, artificial respiration, drugs to reduce blood pressure, antipyretic and anticonvulsants.

Interaction

Drugs exciting sympathetic system, strengthen the effect. The drug cannot be prescribed with Mao inhibitors and antidepressants, since their interaction provokes hypertensive crisis.

Terms of sale

Released without a recipe.

Storage conditions

At temperatures below 250c.

Shelf life

Xilomezoline during pregnancy

To reduce the discharge from the nose during pregnancy, xylometazoline can be used. The experience of using this drug in pregnant women is limited, however, short-term use is allowed in minimal doses under the strict control of the doctor.
Oxymetazolin, despite the fact that it is also a derivative of imidazoline, during pregnancy is contraindicated.

Xilomezoline for children

For acute rhinee Children do not preferably apply vaconishing means short action: , Tetrizolin, Ephedrine Since after their application there is a return swelling of the nasal mucosa. Preferably, use long-term preparations: Xylometazoline ( , ), Oxymetazolin ( ), ( ), which reduces the multiplicity of application.

Remember that a risk group in terms of poisoning with imidazoline preparations (xylometazoline) are children under 2 years old. This drug is not recommended to apply in newborns, babies and in children under 2 years old. In rare cases, if there is no alternative, 0.05% of drops of children under 2 years are prescribed.

For children, over 2 years old, only 0.05% concentration of this drug is used, while it is necessary to strictly dose and abide by the multiplicity of use.

From 2 to 6 years 0.05% drop 1 - 2 drops in every move twice a day, if necessary, applying to 3 times a day.
From 6 to 12 years old can be used 0.05% drops and 0.05% spray 2-3 drops or one injection into each course, but not more than 3 times a day.

Children over 7 years old are prescribed 0.05% gel - lay 3-4 times a day deep in every move.

C12 years apply 0.1% drops and spray.

It should be borne in mind that frequent and long-term (more than 5 days, in some authors - more than 3 days) the use of this drug can cause a pronounced decrease in local blood flow, as a result of which inadequate blood supply to the mucous membrane develops up to its atrophy. In this regard, you should not use the drug of any form of release more than 3 times a day and more than 3-5 days.