Medicinal reference book geotar. Desal for allergies: description, instructions and application Disal tablets for allergies instructions

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In this article, you can read the instructions for using the drug Desal... Feedback from website visitors - consumers are presented of this medicine, as well as the opinions of doctors of experts on the use of Desal in their practice. A big request is to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed that may not have been declared by the manufacturer in the annotation. Desal's analogs in the presence of existing structural analogs. Use for the treatment of urticaria, rhinitis and other manifestations of allergies in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Desal - blocker of histamine H1 receptors ( long acting). It is the primary active metabolite of loratadine. Inhibits the release of histamine and leukotriene C4 from mast cells. Prevents the development and facilitates the course of allergic reactions. It has antiallergic, antipruritic and antiexudative effect. Reduces capillary permeability, prevents the development of tissue edema, relieves spasm of smooth muscles. Has practically no sedative effect and when taken in a dose of 7.5 mg does not affect the speed of psychomotor reactions. In comparative studies of desloratadine and loratadine, there were no qualitative or quantitative differences in the toxicity of the two drugs in comparable doses (taking into account the concentration of desloratadine).

Structure

Desloratadine + excipients.

Pharmacokinetics

After oral administration, it begins to be determined in plasma after 30 minutes. Food has no effect on distribution. Bioavailability is dose proportional, ranging from 5 mg to 20 mg. Plasma protein binding is 83-87%. Does not penetrate the blood-brain barrier (BBB). It is extensively metabolized in the liver by hydroxylation to form 3-OH-desloratadine, combined with glucuronide, only a small part of the dose taken orally is excreted by the kidneys (less than 2%) and with feces (less than 7%).

Indications

• seasonal allergic rhinitis (sneezing, nasal congestion, rhinorrhea, itchy nose, itchy palate, itchy and red eyes, watery eyes)
• chronic idiopathic urticaria ( itchy skin, rash).

Release forms

Oral solution (sometimes mistakenly called syrup).

Coated tablets 5 mg.

Instructions for use and dosage

Adults and adolescents aged 12 years and older are prescribed orally, regardless of food intake, at a dose of 5 mg per day.

Children aged 1 to 5 years - 1.25 mg once a day, aged 6 to 11 years - 2.5 mg once a day.

Pills

Adults and adolescents (12 years and older) - 5 mg (1 tab.) 1 time per day.

Side effect

• increased fatigue;
• dryness of the oral mucosa;
• headache;
• hallucinations;
• dizziness;
• drowsiness;
• insomnia;
• tachycardia;
• palpitations;
• abdominal pain;
• nausea, vomiting;
• dyspepsia;
• diarrhea;
• increased activity of liver enzymes;
• hepatitis;
• myalgia;
• anaphylaxis;
• angioedema;
• rash;
• hives.

Contraindications

• pregnancy;
• period of breastfeeding;
• children under 12 years of age (for tablets) and up to 1 year (for solution) (efficacy and safety have not been established);
• hypersensitivity to the active or any auxiliary substance of the drug.

Application during pregnancy and lactation

The use of Desal during pregnancy is not recommended due to the lack of clinical data on the safety of its use during this period.

Application in children

Prescribing is contraindicated in children under 12 years of age (for tablets) and under 1 year of age (for solution), because efficacy and safety have not been established.

special instructions

Drug interactions

Desloratadine does not increase the effect of ethanol (alcohol) on the central nervous system.

Analogues of the drug Desal

Structural analogues for the active substance:

• Desloratadine;
• Lordestine;
• Nalorius;
• Ezlor;
• Elisey;
• Erius.

Analogs on pharmacological group (antihistamines):

• Alerza;
• Allergodil;
• Allergoferon;
• Allertek;
• Astemizole;
• Betadrine;
• Vibrocil;
• Histaglobin;
• Histalong;
• Gistaphen;
• Gifast;
• Desloratadine;
• Diazolin;
• Diphenhydramine;
• Dinox;
• Dramina;
• Zincet;
• Zyrtec;
• Zodak;
• Kestin;
• Claritin;
• Clemastine;
• Coldact;
• Ksizal;
• Lomilan;
• Loratadine;
• Lordestine;
• Lotaren;
• Mebhydrolin;
• Okumetil;
• Orinol;
• Parlazin;
• Pipolfen;
• Rivtagil;
• Rupafin;
• Suprastin;
• Suprastinex;
• Tavegil;
• Telfast;
• Fexofenadine;
• Femizol;
• Pheniramine maleate;
• Fenistil;
• Fenkarol;
• Chloropyramine;
• Cetirizine;
• Cetrin;
• Ezlor;
• Eladon;
• Ergoferon;
• Erespal;
• Erius;
• Erolyn.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases from which the corresponding drug helps and see the available analogues for the therapeutic effect.

INSTRUCTION
on the use of the medicinal product
for medical use

LP 002155-250713

Dosage form:

film-coated tablets

Structure:

1 coated tablet contains:

active substance:

desloratadine 5.00 mg;

excipients:

microcrystalline cellulose 55.00 mg, pregelatinized corn starch 15.00 mg, mannitol 22.00 mg, talc 2.50 mg, magnesium stearate 0.50 mg;

film casing:

Opadry blue 03F20404 (hypromellose 6cP - 1.90 mg, titanium dioxide (E 171) 0.61 mg, macrogol 6000 - 0.34 mg, dye indigo carmine aluminum varnish (E 132) 0.14 mg) about 3.00 mg.

Description
Round, biconvex, blue film-coated tablets with LT engraving on one side.

ATX code: R06AX27

Inhibits the cascade of reactions of allergic inflammation, incl. release of pro-inflammatory cytokines, including interleukins IL-4, IL-6, IL-8, IL-13, release of proinflammatory chemokines, production of superoxide anions by activated polymorphonuclear neutrophils, adhesion and chemotaxis of eosinophils, release of adhesion molecules such as P-IgE mediated release of histamine, prostaglandin D

and leukotriene C

Thus, it prevents the development and facilitates the course of allergic reactions, has an antipruritic and antiexudative effect, reduces capillary permeability, prevents the development of tissue edema, spasm of smooth muscles. The drug has no effect on the central nervous system (CNS), has practically no sedative effect (does not cause drowsiness) and does not affect the speed of psychomotor reactions when taken in recommended doses. Does not cause prolongation of the QT interval on the electrocardiogram.

Pharmacokinetics
Suction
After taking the drug inside, desloratadine is well absorbed from the gastrointestinal tract. Determined in blood plasma after 30 minutes, and the maximum concentration in blood plasma (Cmax) is reached after approximately 3 hours. Not observed clinically significant changes concentration of desloratadine in blood plasma with repeated administration of ketoconazole and erythromycin. The bioavailability of desloratadine is dose-proportional at doses ranging from 5 mg to 20 mg.
Distribution
The connection with plasma proteins is 83-87%. When used in adults and adolescents for 14 days at a dose of 5 mg to 20 mg 1 time / day, there are no signs of clinically significant cumulation of desloratadine. The degree of desloratadine accumulation is consistent with the half-life (T1 / 2) and the frequency of its use once a day. The values \u200b\u200bof the area under the pharmacokinetic curve "concentration-time" and Cmax in children were similar to those in adults who received 5 mg of desloratadine.
The simultaneous intake of food or grapefruit juice does not affect the distribution of desloratadine (when taken at a dose of 7.5 mg 1 time / day). Does not penetrate the blood-brain barrier.
Metabolism
Withdrawal
The terminal phase T1 / 2 is about 27 hours. Desloratadine is excreted from the body in the form of a glucuronide compound and in a small amount unchanged (by the kidneys - less than 2% and through the intestines - less than 7%).

Carefully

heavy renal failure.
Structure

Part solution, intended for oral administration, contains 0.5 mg (content in 1 ml) Desloratadine.

Part pills enters active substance desloratadine in an amount of 5 mg.

The film casing contains the following components:

• macrogol;
• titanium dioxide;
• aluminum varnish (Indigocarmine dye);
• drop blue.

The medication is available in two dosage forms :

• tablets in a special film cover;
• solution for per os administration (preferably for children in view of ease of use).

Desal tablets have a blue color due to the film shell; rounded biconvex shape. "LT" is engraved on one side. Packed in blister packs of 10 pieces. A pack made of cardboard can contain 1, 2 or 3 convolutes with tablets.

Desal syrup - colorless liquid, free from foreign particles. The solution is available in bottles of 50, 60, 100, 120, 150, 300 ml. The pack additionally contains a syringe dispenser or a measuring spoon.

Antihistamine prolonged action. The active component blocks peripherally located H1 receptors. Primary metabolite loratadine (active form) is desloratadine.

The principle of action is based on inhibition of the cascade of reactions of allergic inflammatory processes:

• release of anti-inflammatory chemokines;
• release interleukins IL-4,8,13 and other anti-inflammatory cytokines;
• isolation of adhesion molecules (P-selectin);
• chemotaxis and and adhesion eosinophils;
• production of superoxide anions activated by polymorphonuclear neutrophils;
• IgE-mediated release of prostaglandin D2, histamine and leukotriene C4.

The cascade of the above reactions allows you to prevent the development and facilitate the course allergic responses:

• prevent development tissue edema;
• spasm of smooth muscle tissue is prevented;
• decreases capillary permeability;
• appears antiexudative and antipruritic action.

The drug does not change the speed of psychomotor reactions, does not sedative effect (not developing drowsiness during treatment). On the electrocardiogram, lengthening of the QT interval is not recorded. The active substance begins its effect within half an hour after taking the medication, the effect lasts a day.

Suction

The active ingredient is well absorbed from the lumen digestive tract... IN blood plasma determined after half an hour, and the maximum concentration is recorded after 3 hours. With repeated use Erythromycin and Ketoconazole clinically significant changes in the concentration of the active substance are not recorded.

The connection with plasma proteins reaches 83-87%. Clinically significant cumulation when taken by adults and adolescents at a dose of 5-20 mg (1 time per day) for 2 weeks is not observed. The degree of cumulation of the active substance is consistent with the frequency of use and the value of the half-life. Grapefruit juice and food intake do not change the distribution of the active substance. Desloratadine does not pass through blood-brain barrier.

Today, all enzymes responsible for metabolism Desloratadine are unknown, which does not exclude the possibility of interaction with other medicines... It is reliably known that the active component is not an inhibitor of P-glycoprotein or its substrate, does not inhibit enzymes CYP2D6 and CYP3A4. It is metabolized by hydroxylation in the hepatic system to form 3-OH-Desloratadine, which reacts further glucuronidation.

In a small amount, the active component is excreted in its original form (through the intestines - less than 7%, with urine - less than 2%). Most of Desloratadine is excreted as a glucuronide compound. The terminal phase of the half-life is 27 hours.

An antihistamine medication is prescribed to patients in order to alleviate or eliminate the following symptoms:

• hives (skin rashes, itching);
• allergic rhinitis (itching in the nose, nasal congestion, watery eyes, eye redness, rhinorrhea, sneezing, palatine itching).

With pathology of the renal system (failure), Desal is prescribed with caution.

Additional contraindications for taking the solution:

• impaired absorption of galactose or glucose, lack of isomaltase or sucrose in the body and similar hereditary diseases (the limitation is associated with sorbitol, which is contained in the drug);
• the age limit is up to 1 year.

Most often, negative reactions are recorded:

• headache;
• dryness of the mucous membranes in the mouth;
• fast fatiguability.

The incidence of drowsiness with 5 mg daily was similar to that of the placebo control group.

The following negative symptoms and reactions are extremely rare:

• insomnia;
• hallucinations;
• dizziness;
• psychomotor hyperactivity;
• increased sleepiness;
• feeling of rapid heartbeat, tachycardia;
• diarrheal syndrome;
• myalgia;
• hepatitis;
• level up bilirubin;
• increased activity of enzymes of the hepatic system;
• dyspepsia;
• epigastric pain syndrome;
• nausea, vomiting.

Instructions for use of Desal (Way and dosage)

The antihistamine is available in two dosage forms, for each of which the manufacturer has developed its own treatment regimen. About how many days you can take the medicine, you need to check with the attending physician who prescribed the medicine.

The tablet form of the medication is intended for oral administration regardless of food. Dosage regimen: 1 tablet (5 mg) once a day.

Adults are prescribed 5 mg (corresponding to 10 ml of solution) once a day.

Children 6-11 years old appoint 2.5 mg (5 ml of solution) once a day.

Children 1-5 years old appoint 1.25 mg (corresponding to 2.5 ml of solution).

Drops are prescribed when it is impossible to use the tablet form. The solution is most often used in pediatric practice.

Taking 45 mg of Desloratadine (nine times the recommended dose) does not lead to the manifestation of any specific symptoms. Sleepiness is theoretically possible. In case of overdose, syndromic therapy is required, reception is effective Activated carbon and gastric lavage. Efficiency peritoneal dialysis not installed. It has been proven that the active substance with hemodialysis is not displayed.

Allergy tablets, as well as syrup, do not enter into clinically significant interactions with other medications (including Erythromycin, Ketoconazole). No effect on central department nervous system... The medication does not enhance the effect Ethanol.

Desal is a non-prescription drug. It is sold through pharmacy chains.

The syrup and tablets must be protected from direct sunlight. The manufacturer's recommended storage temperature for vials and blisters is up to 25 degrees.

36 months.

There is no evidence base on the safety and effectiveness of Desal's use in pediatric practice in children under 1 year of age.

Differential diagnosis between allergic rhinitis and rhinitis of a different genesis in children under two years of age presents certain difficulties for doctors. To establish the correct diagnosis, it is necessary to conduct a thorough history taking, pay attention to the presence / absence of structural abnormalities or infectious foci in upper sections respiratory tract, conduct a thorough examination, skin tests and the corresponding laboratory tests.

About 6% of adult patients and children 2-11 years old are prone to slow metabolism of desloratadine, which prolongs the period of its elimination. Impaired concentration of attention while taking an antihistamine is not observed (drowsiness is possible).

Analogs are cheaper than the original drug.

Erius is the original drug, and Desal is its generic. The difference between generic drugs is that they have not been clinically tested. The composition of the two preparations is absolutely identical. Comparison of Erius with generics is impractical, because original drug meets quality standards, which at the same time affects its cost (generics are cheaper). Desala assures that Desal knows your allergy from A to Z. The original Erius claims that a powerful allergy response is formed through a triple mechanism of action.

In pediatric medical practice, preference is given to the Desal solution, which is more convenient not only to dose, but also to give to children of the younger age group (taking pills is difficult).

Desal is not prescribed for children under one year of age.

No interactions with ethanol have been reported.

Contraindicated.

Patients leave mostly positive reviews about Desal. An indisputable advantage is the affordable cost, unlike the original drug... The tablets are easy to use (1 time per day), do not cause drowsiness, and allow you to quickly stop an allergic reaction. Reviews of the syrup for children are also positive: ease of dosing, high efficiency, easy tolerance, lack of pronounced side effects, affordable cost.

Desal's price in tablets is 150 rubles. The price of Desal syrup is slightly higher - 250 rubles. You can buy the medication at the pharmacy.

Desal tablets 5 mg 10 pcs Actavis

Desal solution 0.5 mg / ml 100 ml Actavis

Desal 5mg No. 30 tablets Actavis Ltd

Desal 5mg No. 10 tablets Actavis Ltd

Desal 0.5mg / ml oral solution 100ml Actavis Ltd

Dezal Actavis ht., Iceland

Dezal Actavis ht., Iceland

Dezal Actavis ht., Iceland

Clinical and pharmacological group

Histamine H blocker

Receptors.

Antiallergic

a drug

Release form, composition and packaging

◊ Film-coated tablets light blue, round, biconvex, engraved with "LT" on one side.

Excipients: microcrystalline cellulose - 55 mg, pregelatinized corn starch - 15 mg, mannitol - 22 mg, talc - 2.5 mg, magnesium stearate - 0.5 mg.

Film casing composition: opadry blue 03F20404 (hypromellose 6cP - 1.9 mg, titanium dioxide (E171) - 0.61 mg, macrogol 6000 - 0.34 mg, dye indigo carmine aluminum varnish (E132) - 0.14 mg) - about 3 mg.

10 pieces. - blisters (1) - cardboard packs.
10 pieces. - blisters (2) - cardboard packs.
10 pieces. - blisters (3) - cardboard packs.

pharmachologic effect

Long-acting antihistamine, blocker of peripheral histamine H1 receptors. Desloratadine is the primary active metabolite of loratadine. Inhibits the cascade of reactions of allergic inflammation, incl. release of proinflammatory cytokines, including interleukins IL-4, IL-6, IL-8, IL-13, release of pro-inflammatory chemokines, production of superoxide anions by activated polymorphonuclear neutrophils, adhesion and chemotaxis of eosinophils, release of adhesion molecules such as P-IgE mediated release of histamine, prostaglandin D2 and leukotriene C4.

Thus, it prevents the development and facilitates the course of allergic reactions, has an antipruritic and antiexudative effect, reduces capillary permeability, prevents the development of tissue edema, spasm of smooth muscles.

The drug has no effect on the central nervous system, practically does not have a sedative effect (does not cause drowsiness) and does not affect the speed of psychomotor reactions when taken in recommended doses. Does not cause prolongation of the QT interval on the ECG.

The action of desloratadine begins within 30 minutes after ingestion and lasts for 24 hours.

Pharmacokinetics

Suction

After taking the drug inside, desloratadine is well absorbed from the gastrointestinal tract. It is determined in blood plasma after 30 minutes, and Cmax is reached after approximately 3 hours. There were no clinically significant changes in the concentration of desloratadine in blood plasma with repeated administration of ketoconazole and erythromycin. The bioavailability of desloratadine is dose proportional with a dose ranging from 5 mg to 20 mg.

Distribution

Plasma protein binding is 83-87%. When used in adults and adolescents for 14 days at a dose of 5 mg to 20 mg 1 time / day, there are no signs of clinically significant cumulation of desloratadine. The degree of desloratadine cumulation is consistent with the T1 / 2 value and the frequency of its use 1 time / day. The AUC and Cmax values \u200b\u200bin children were similar to those in adults who received 5 mg desloratadine.

Simultaneous intake of food or grapefruit juice does not affect the distribution of desloratadine (when taken at a dose of 7.5 mg 1 time / day). Does not penetrate the BBB.

Metabolism

The enzymes responsible for the metabolism of desloratadine are not yet known, so interactions with some drugs cannot be completely ruled out. It is not an inhibitor of CYP3A4 and CYP2D6 and is not a substrate or inhibitor of P-glycoprotein. It is extensively metabolized in the liver by hydroxylation to form 3-OH-desloratadine, which is then glucuronized.

Withdrawal

The terminal phase T1 / 2 is about 27 hours. Desloratadine is excreted from the body in the form of a glucuronide compound and in small amounts unchanged (with urine - less than 2% and through the intestines - less than 7%).

Indications

To relieve or eliminate symptoms:

Allergic rhinitis (sneezing, nasal congestion, rhinorrhea, itchy nose, itchy palate, itchy and red eyes, watery eyes);

Urticaria (itching, rash).

Contraindications

Pregnancy;

Breastfeeding period;

Children under 12 years of age (efficacy and safety have not been established);

Hypersensitivity to the active or any excipient of the drug.

FROM caution the drug should be used in severe renal failure.

Dosage

Inside, regardless of the meal.

Adults and adolescents (12 years and older) - 5 mg (1 tab.) 1 time / day.

Side effects

More often than others, the following undesirable reactions are noted: increased fatigue (1.2%), dryness of the oral mucosa (0.8%), headache (0.6%).

When using the drug in adults and adolescents at the recommended dose of 5 mg / day, the incidence of drowsiness is not higher than when using a placebo.

During post-marketing surveillance, the following adverse reactions were very rarely observed.

Mental disorders:hallucinations.

From the side of the central nervous system:dizziness, drowsiness, insomnia, psychomotor hyperactivity.

From the side of cardio-vascular system: tachycardia, palpitations.

From the side digestive system: abdominal pain, nausea, vomiting, dyspepsia, diarrhea.

From the liver and biliary tract:increased activity of liver enzymes, increased concentration of bilirubin, hepatitis.

From the musculoskeletal system:myalgia.

Allergic reactions:anaphylaxis, angioedema, pruritus, rash, urticaria.

Overdose

Symptoms:taking in a dose exceeding the recommended 9 times (45 mg) did not lead to the appearance of any clinically significant symptoms... Drowsiness may develop.

Treatment:necessary gastric lavage, intake of activated carbon; if necessary, symptomatic therapy. Desloratadine is not excreted during hemodialysis, the effectiveness of peritoneal dialysis has not been established.

In case of accidental ingestion of a large amount of the drug, the patient should immediately consult a doctor.

Drug interactions

No clinically significant interactions with other drugs have been identified (including with ketoconazole and erythromycin).

Desloratadine does not enhance the effect of ethanol on the central nervous system.

special instructions

In case of severe renal dysfunction, Desal should be taken with caution.

Impact on management ability vehicles and mechanisms

In studies, there was no effect of desloratadine on driving. However, it should be borne in mind that very rarely some patients may develop drowsiness, in this case, care should be taken when driving and when working with mechanisms.

Pregnancy and lactation

Prescribing the drug during pregnancy is not recommended due to the lack of clinical data on the safety of its use during this period.

Desloratadine is excreted with breast milktherefore, its use during breastfeeding is not recommended.

Application in childhood

Prescription for children under 12 years of age is contraindicated, because efficacy and safety have not been established.

The drug should be used with caution in severe renal failure.

The drug is approved for use as a means of OTC.

The drug should be stored out of the reach of children, dry, protected from light, at a temperature not exceeding 25 ° C. Shelf life is 2 years.

Desal tablets- a long-acting antihistamine, blocker of peripheral H1-histamine receptors. Desloratadine is the primary active metabolite of loratadine. Inhibits the cascade of reactions of allergic inflammation, incl. release of proinflammatory cytokines, including interleukins IL-4, IL-6, IL-8, IL-13, release of pro-inflammatory chemokines, production of superoxide anions by activated polymorphonuclear neutrophils, adhesion and chemotaxis of eosinophils, release of adhesion molecules such as P-IgE mediated release of histamine, prostaglandin D2 and leukotriene C4. Thus, it prevents the development and facilitates the course of allergic reactions, has an antipruritic and anti-exudative effect, reduces capillary permeability, prevents the development of tissue edema, spasm of smooth muscles. The drug has no effect on the central nervous system (CNS), has practically no sedative effect (does not cause drowsiness) and does not affect the speed of psychomotor reactions when taken in recommended doses. Does not cause prolongation of the QT interval on the electrocardiogram.
The action of desloratadine begins within 30 minutes after ingestion and lasts for 24 hours.

Pharmacokinetics

After taking the drug inside, desloratadine is well absorbed from the gastrointestinal tract. It is determined in blood plasma after 30 minutes, and the maximum concentration in blood plasma (Cmax) is reached after approximately 3 hours. There were no clinically significant changes in the concentration of desloratadine in blood plasma with repeated administration of ketoconazole and erythromycin. The bioavailability of desloratadine is dose-proportional at doses ranging from 5 mg to 20 mg.
The connection with plasma proteins is 83-87%. When used in adults and adolescents for 14 days at a dose of 5 mg to 20 mg 1 time / day, there are no signs of clinically significant cumulation of desloratadine. The degree of desloratadine accumulation is consistent with the half-life (T1 / 2) and the frequency of its use once a day. The values \u200b\u200bof the area under the pharmacokinetic curve "concentration-time" and Cmax in children were similar to those in adults who received 5 mg of desloratadine.
The simultaneous intake of food or grapefruit juice does not affect the distribution of desloratadine (when taken at a dose of 7.5 mg 1 time / day). Does not penetrate the blood-brain barrier.
The enzymes responsible for the metabolism of desloratadine are not yet known, so interactions with some drugs cannot be completely ruled out. It is not an inhibitor of CYP3A4 and CYP2D6 and is not a substrate or inhibitor of P-glycoprotein. It is extensively metabolized in the liver by hydroxylation to form 3-OH-desloratadine, which is then glucuronized.
The terminal phase T1 / 2 is about 27 hours. Desloratadine is excreted from the body in the form of a glucuronide compound and in a small amount unchanged (by the kidneys - less than 2% and through the intestines - less than 7%).

Indications for use

Recommended tablets Desaltake to relieve or eliminate symptoms: allergic rhinitis (sneezing, nasal congestion, rhinorrhea, itchy nose, itchy palate, itching and redness of the eyes, watery eyes); urticaria (itching, rash).

Mode of application

Desal pillstaken orally, regardless of food intake.
Adults and adolescents (12 years and older) - 1 tablet 5 mg 1 time per day.

Side effects

More often than others, the following adverse reactions are noted: increased fatigue (1.2%), dryness of the oral mucosa (0.8%), headache (0.6%).
When using the drug in adults and adolescents at the recommended dose of 5 mg / day, the incidence of drowsiness is not higher than when using a placebo.
During post-marketing surveillance, the following adverse reactions were very rarely observed.
Mental disorders: hallucinations.
From the side of the central nervous system: dizziness, drowsiness, insomnia, psychomotor hyperactivity.
From the side of the cardiovascular system: tachycardia, palpitations.
From the digestive system: abdominal pain, nausea, vomiting, dyspepsia, diarrhea.
From the liver and biliary tract: increased activity of liver enzymes, increased concentration of bilirubin, hepatitis.
From the musculoskeletal system: myalgia.
Allergic reactions: anaphylaxis, angioedema, itching, rash, urticaria.

Contraindications

:
Contraindications to the use of the drug Desalare: hypersensitivity to the active or any auxiliary substance of the drug; pregnancy; period of breastfeeding; age up to 12 years (efficacy and safety have not been established).
With caution - severe renal failure.

Pregnancy

:
Application of the drug Desalduring pregnancy is not recommended due to the lack of clinical data on the safety of its use during this period.
Desloratadine is excreted in breast milk, so its use during breastfeeding is not recommended.

Interaction with other medicinal products

Clinically significant interactions Desala pillswith other drugs not identified (including ketoconazole and erythromycin).
Desloratadine does not increase the effect of ethanol on the central nervous system.

Overdose

:
Symptoms: Taking a dose 9 times the recommended dose (45 mg) did not lead to the appearance of any clinically significant symptoms. Drowsiness may develop.
Treatment: it is necessary to wash the stomach, take activated carbon; if necessary, symptomatic therapy. Desloratadine is not excreted during hemodialysis, the effectiveness of peritoneal dialysis has not been established.

Storage conditions

In a dry, dark place at a temperature not exceeding 25 ° C.
Keep out of the reach of children!

Release form

Film-coated tablets 5 mg. 10 tablets in blister Al / Al.
1, 2 or 3 blisters each with instructions for medical use in a cardboard box.

Structure

:
1 tablet Desalcoated contains: active substance: desloratadine 5.00 mg.
Excipients: microcrystalline cellulose 55.00 mg, pregelatinized corn starch 15.00 mg, mannitol 22.00 mg, talc 2.50 mg, magnesium stearate 0.50 mg.
Film sheath: Opadry blue 03F20404 (hypromellose 6cP - 1.90 mg, titanium dioxide (E 171) 0.61 mg, macrogol 6000 - 0.34 mg, dye indigo carmine aluminum varnish (E 132) 0.14 mg) about 3, 00 mg.

Additionally

:
In case of severe renal dysfunction, the drug Desalshould be taken with caution.
Influence on the ability to drive vehicles and mechanisms
In studies, there was no effect of desloratadine on driving. However, it should be borne in mind that very rarely some patients may develop drowsiness, in this case, care should be taken when driving and when working with mechanisms.

Main settings

Name:	DEZAL TABLETS
ATX code:	R06AX27 -

How to use the drug "Disal"? Instructions for using this tool will be presented below. You will also learn about what components are included in the mentioned medication, in what form it is produced, whether it can be prescribed to children and pregnant women.

Composition, form, description of the medicinal product

What components does Disal contain? The instructions for which are included in the carton are blue, biconvex and round, and are engraved with "LT" on one side. The active ingredient in this medication is desloratadine. It also contains additional ingredients in the form of microcrystalline cellulose mannitol, pregelatinized corn starch, magnesium stearate and talc.

As for the film coat of the tablets, they include blue opadry, macrogol and indigo carmine dye.

It should be noted that the drug in question is produced in the form of a syrup. His active substance desloratadine also acts.

Pharmacology

How does Disal (allergy tablets) work? The instructions attached to this tool say that it is a long-acting antihistamine. It is a blocker of peripheral histamine H1 receptors.

The active substance of this medication is the primary active metabolite of loratadine. It inhibits allergic reactions by releasing pro-inflammatory cytokines and chemokines. Also, this component reduces the production of superoxide anions, chemotaxis and eosinophil adhesion.

This effect of the drug helps to prevent the development and alleviate allergic reactions. The drug in question has anti-exudative and antipruritic properties, prevents the development of smooth muscle spasms, tissue edema and reduces capillary permeability.

Disal tablets, the price of which will be indicated below, does not have any effect on the central nervous system, and also does not have a sedative effect (that is, does not cause drowsiness) and does not affect the psychomotor response of a person (when taking the recommended dosages). In addition, the medication in question does not lengthen the QT interval on the ECG.

The therapeutic effect of this drug begins within half an hour after ingestion and lasts throughout the day.

Pharmacokinetics

What pharmacokinetic indicators does the drug "Disal" (tablets for allergies) have? The instruction says that after taking the drug, its active substance is well absorbed from the gastrointestinal tract. In blood plasma, it is determined after half an hour, and its maximum concentration is reached in about three hours.

The connection with plasma proteins of the drug is 85-87%, and the half-life is about 28 hours. Desloratadine is excreted from the body through the intestines (less than 7%) and together with urine (less than 2%).

Indications for use

This drug helps with allergies on the face very well. It is used not only to relieve but also to eliminate the following symptoms:

• hives (rash and itchy skin);
• allergic rhinitis (rhinorrhea, sneezing, itchy palate, nasal congestion, redness and itching of the eyes, itchy nose, watery eyes).

Contraindications for use

It is prohibited to use the drug "Disal". Also, it is not prescribed for breastfeeding and in children under 12 years of age (safety and efficacy have not been established). Do not use this medication when hypersensitivity the patient to the active or any additional ingredient of the drug.

With extreme caution, Disal tablets are prescribed for severe renal failure.

The drug "Disal" (tablets for allergies): instructions

Only a narrow specialist should prescribe such pills. Allergies (urticaria, itching, rash, etc.) in children from 12 years old and adult patients are eliminated in the same way. According to the instructions, the tablets must be taken orally, regardless of the meal. The dosage of this medication is determined by the doctor and, as a rule, it is 5 mg once a day (that is, 1 tablet a day).

Adverse reactions

For allergies for children over 12 years old, the drug "Disal" should be prescribed with extreme caution. This is due to the fact that this medication can cause a large number of side effects.

More often than others, patients have such adverse reactions as fatigue, persistent headaches and dry mouth.

The observations also revealed other side effects... Let's imagine them right now:

• On the part of the nervous system, drowsiness, psychomotor hyperactivity, dizziness and insomnia may be noted.
• On the part of the digestive tract, abdominal pain, diarrhea, nausea, dyspepsia and vomiting are observed.
• On the part of the biliary tract and the liver, phenomena such as an increase in the concentration of bilirubin, an increase in the activity of liver enzymes and hepatitis occur.
• From the side of the heart and blood vessels, patients are worried about tachycardia and a feeling of palpitations.
• On the part of the bone and muscular system, myalgia is observed.

It should also be noted that while taking the drug in question, patients may experience mental disorders in the form of hallucinations and allergic reactions in the form of itching, anaphylaxis, rash, angioedema and urticaria.

Signs of overdose

For allergies for children over 12 years old, as well as for adults, the drug "Disal" should be taken in the dosages recommended by the doctor.

When taking medication in higher doses (for example, 9 times, which is 45 mg) does not occur any clinically significant signs. However, drowsiness may develop.

As a treatment, it is required to rinse the stomach and take activated carbon... It should also be noted that desloratadine is not excreted by hemodialysis.

Compatibility with other medicines

Interaction of the drug "Disal" with other drugs has not been identified (including "Erythromycin" and "Ketoconazole"). It should also be said that desloratadine does not enhance the effect of ethanol on the central nervous system.

Allergies (urticaria, itching, rash, etc.) in people with severe renal impairment should be treated with extreme caution.

According to research, the drug "Disal" does not affect the patient's vehicle management. But it should be borne in mind that it is extremely rare for some people to develop drowsiness. In this case, you must observe extra care when driving and when working with complex mechanisms.

The cost and analogues of the medicinal product

Unlike other anti-allergic drugs, the price of the drug "Disal" is not very high. You can buy this medication for 200-350 rubles (10 and 30 tablets, respectively).

As for the analogues of the medication in question, there are a great many of them. Let's list them: "Lordestin", "Blogir-3", "Erius", "Desloratadin", "Elisey", "Desloratadin-Teva", "Ezlor", "Desloratadin Canon", "Nalorius", "Desloratadin-Pharmaplant".