Renewal instructions for use. The drug Nicotinic acid Reneval: instructions for use
Composition and release form of the drug
10 pieces. - contour cell packaging (5) - cardboard packs.
10 pieces. - contour cell packaging (10) - cardboard packs.
pharmachologic effect
A product containing inorganic. When iodides enter the epithelial cells of the thyroid follicle under the influence of the enzyme iodide-peroxidase, iodine is oxidized to form elemental iodine, which is incorporated into the tyrosine molecule. In this case, one part of the tyrosine radicals in thyroglobulin is iodized. Iodinated tyrosine radicals are condensed into thyronines, the main of which are thyroxine (T 4) and triiodothyronine (T 3). The resulting complex of thyronine and thyroglobulin is released as a deposited form of thyroid hormone into the colloid of the follicle and remains in this state for several days or weeks. With iodine deficiency, this process is disrupted. Potassium iodide, compensating for iodine deficiency, helps to restore the impaired synthesis of thyroid hormones.
With a normal iodine content in the environment, under the influence of an excess of iodides, the biosynthesis of thyroid hormones is inhibited, their release from thyroglobulin, the sensitivity of the thyroid gland to thyroid stimulating hormone of the pituitary gland decreases and its secretion by the pituitary gland is blocked.
Pharmacokinetics
When taken orally, it is rapidly absorbed from the gastrointestinal tract. It is widely distributed in all tissues and body fluids.
Indications
Prevention and treatment endemic goiter... Prevention of recurrence of goiter during the period complex treatment preparations of thyroid hormones.
Contraindications
Severe hyperthyroidism, latent hyperthyroidism (when used in doses exceeding 150 μg / day), toxic adenoma, nodular or diffuse toxic goiter (when used at doses of 300-1000 μg / day), herpetiformis (Duhring's disease), pregnancy and breastfeeding ( when used in doses of 1-2 mg / day), hypersensitivity to iodine preparations.
Dosage
Individual. The daily dose in terms of iodine is 50-100 mcg for children, and 100-200 mcg for adolescents and adults.
Side effects
Manifestations of iodism: swelling of the nasal mucosa, urticaria, eosinophilia, shock; also possible tachycardia, irritability, sleep disturbances, increased sweating, diarrhea (in patients over 40); in some cases, when used in doses exceeding 300-1000 mcg / day, hyperthyroidism may develop (especially in elderly patients, in the presence of nodular or diffuse toxic goiter); with high-dose therapy (more than 1 mg / day), goiter caused by iodine and, accordingly, may develop.
Drug interactions
With simultaneous high-dose therapy with iodine and potassium-sparing diuretics, hyperkalemia may develop, with lithium preparations - the development of goiter and hypothyroidism. Perchlorate and thiocyanate competitively inhibit the absorption of iodine by the thyroid gland, while TSH stimulates it.
Instructions for the use of Potassium iodide
Buy Potassium iodide Reneval TB 200mcg
Dosage forms
tablets 200mcg
Manufacturers
Update PKF (Russia)
Group
Products containing iodine
Composition
Active substance - Potassium iodide.
International non-proprietary name
Potassium iodide
Synonyms
Iodine Vitrum, Iodine Vitrum for children, Iodbalance, Iodomarin 100, Iodomarin 200, Iodostin, Potassium iodide 200 Berlin-Chemie, Potassium iodide, Microiodide
pharmachologic effect
Iodine is a vital trace mineral. Without iodine, the normal functioning of the thyroid gland is impossible, the hormones of which perform many vital functions. They are responsible for the metabolism of proteins, fats, carbohydrates and energy in the body; regulate the activity of the brain, nervous and of cardio-vascular system, genitals and mammary glands, growth and development of the child. The lack of iodine is especially dangerous for children, adolescents, pregnant and lactating women.
Indications for use
- prevention of diseases associated with iodine deficiency in the environment, primarily in children, adolescents, pregnant and lactating women; - treatment of diffuse non-toxic goiter; - treatment of diffuse euthyroid goiter caused by iodine deficiency in children, adolescents and adults.
Contraindications
- increased thyroid function; - hypersensitivity to iodine; - toxic adenoma of the thyroid gland, nodular goiter (when used in doses from 300 to 1000 mcg / day), with the exception of preoperative iodine therapy; - Herpetiformis (senile) Dühring's dermatitis.
Side effect
With prophylactic use at any age, as well as in the treatment of goiter in newborns, children and adolescents, side effects are usually not observed. In rare cases, continuous use of the drug can lead to the development of "iodism", which can manifest itself metallic taste in the mouth, swelling and inflammation of the mucous membranes (runny nose, conjunctivitis, bronchitis), "iodine fever", "iodine acne". It is extremely rare for the development of Quincke's edema, exfoliative dermatitis. When using the drug in a dose exceeding 150 mcg / day, latent hyperthyroidism can turn into a manifest form. When using the drug in a dose exceeding 300-1000 mcg / day, hyperthyroidism may develop (especially in elderly patients suffering from goiter for a long time; in the presence of nodular or diffuse toxic goiter).
Interaction
As a result of the interaction of drugs with each other, mutual strengthening or weakening of their action and the development of side effects are possible, therefore, the attending physician should be informed about which drugs the patient is currently taking or has recently taken. This is especially true for certain drugs used in the treatment of depression (lithium salts); to potassium-sparing diuretics and to substances that inhibit the formation of thyroid hormones.
Overdose
With prolonged administration of high doses of the drug (more than 300 μg per day), the development of iodine-induced hyperthyroidism is possible. With therapy with high doses of iodine (more than 1000 mcg per day), goiter and hypothyroidism caused by iodine may develop in some cases. Symptoms: brown staining of mucous membranes, reflex vomiting (if starch-containing components are present in food, vomit becomes blue), abdominal pain and diarrhea (possibly melena). Treatment for acute intoxication: gastric lavage with a solution of starch, protein or 5% sodium thiosulfate solution until all traces of iodine are removed. Symptomatic therapy of the disorder water balance, electrolyte balance, anti-shock therapy. Treatment for chronic intoxication: drug withdrawal. Treatment of iodine-induced hypothyroidism: withdrawal of the drug, normalization of metabolism with the help of thyroid hormones. Treatment of iodine-induced thyrotoxicosis: with mild forms of treatment is not required; at expressed forms requires thyrostatic therapy (the effect of which is always delayed). In severe cases (thyrotoxic crisis), intensive therapy, plasmaphoresis and thyroidectomy are necessary.
special instructions
During pregnancy and lactation, the need for iodine increases, so it is especially important to use sufficient doses (200 μg / day) to ensure an adequate intake of iodine in the body. The use of the drug during pregnancy and lactation is possible only in recommended doses.
Storage conditions
In a dark place.
Active substance
Potassium iodide
Dosage form
pills
Manufacturer
PFC update, Russia
Composition
Active ingredient - potassium iodide
pharmachologic effect
Potassium iodide, when ingested in physiological quantities in the body, normalizes the production of thyroid hormones (which were disturbed due to a lack of iodine) thyroxine (T4) and triiodothyronine (T3) and the indicators of the T4 / T3 ratio. In the epithelium of the thyroid follicles, under the influence of the thyroid peroxidase enzyme, the drug is oxidized to ordinary iodine, which iodizes the tyrosine residues of the thyroglobulin molecule with the formation of thyroid hormone precursors - diiodotyrosines (DIT) and monoiodotyrosines (MIT), with only 1/5 of the thyrozines there are 140 of them), which are part of thyroglobulin. Under the influence of enzymes DIT and MIT, thyronines are condensed and formed, the main of which are thyroxine (T4) and triiodothyronine (T3). The complex of thyronins with thyroglobulin moves into the follicular cell from the colloid, where it accumulates. The release of thyroid hormones from thyroglobulin occurs in the apex of the thyrocyte due to hydrolysis by lysosomal enzymes. In addition to thyroxine and triiodothyronine, DIT and MIT are also released, which accumulate inside the gland. The introduction of excess potassium iodide (daily more than 6 mg) in hyperthyroidism leads to inhibition of the production and release of TSH from the pituitary gland according to the principle feedback, which leads to inhibition of the synthesis and release of thyroid hormones. Also, potassium iodide reduces the blood supply and the size of the thyroid gland, makes its tissue denser, restores the size of the thyroid gland and prevents its hyperplasia in adolescents and children. In patients with hyperthyroidism, it quickly leads to remission of symptoms, therefore, large doses of iodide are used during the preoperative preparation of patients for resection of the thyroid gland to facilitate thyroidectomy (along with other antithyroid drugs) and with a thyrotoxic crisis. The antithyroid effects of potassium iodide are unstable - last 2–3 weeks and are used to temporarily decrease thyroid function. The radioprotective property of potassium iodide is determined by the fact that the drug prevents the absorption of radioactive isotopes of iodine by the thyroid gland, thereby protecting it from the effects of radiation. When the drug is used together with radiation exposure, the protective effect is approximately 97%; when used 24 or 12 hours before the expected exposure to radiation - respectively, 70% and 90%, when taken 3 or 1 hour after exposure - 50% and 85%, respectively, more than 6 hours - the effect is insignificant. The expectorant property of potassium iodide is due to the fact that, released into the bronchi, the drug causes flushing of the mucous membrane, dilutes sputum, increases the function of the ciliated epithelium and increases mucociliary clearance. There is evidence of the effectiveness of potassium iodide in fungal infections and erythema nodosum. When taken orally completely and rapidly absorbed into small intestine and is distributed in the intracellular space in 2 hours. Mainly accumulates in thyroid gland, in addition, in the mammary and salivary glands, gastric mucosa. It passes well through the placenta. It is mainly excreted by the kidneys (10 minutes after ingestion, it is determined in the urine in trace amounts, 80% of the dose is excreted within 2 days, the rest in 10–20 days), partially - with secretions of bronchial, salivary, sweat and other glands.
Indications
Prevention of iodine deficiency diseases (endemic goiter and others) in areas with iodine deficiency, including adolescents, children, lactating and pregnant women; prevention of recurrence of goiter after resection of the thyroid gland; therapy for goiter and other iodine deficiency diseases in adults, children (including newborns), adolescents; hyperthyroidism; thyrotoxic crisis; to prepare for resection of the thyroid gland; Difficulty passing sputum (with inflammatory diseases upper respiratory tract, bronchial asthma, actinomycosis of the lungs); syphilis (for resorption of infiltrates during the tertiary period) - adjunctive therapy; absorption prevention radioactive iodine thyroid and radiation protection; in dentistry for inflammatory diseases of the salivary glands, xerostomia; in ophthalmology for cataracts, opacity vitreous and cornea, hemorrhage in the membranes of the eye, fungal infections of the cornea and conjunctiva.
Contraindications
Severe hyperthyroidism, latent hyperthyroidism (when using doses exceeding 150 μg / day), toxic adenoma, nodular or diffuse toxic goiter (when used in doses of 300-1000 μg / day), dermatitis herpetiformis (Duhring's disease), pregnancy and breastfeeding ( when used in doses of 1-2 mg / day), hypersensitivity to iodine preparations.
How to take, course and dosage
Inside, after eating, with plenty of liquid. Goiter treatment for adults and children over 12 years old - 300-500 mcg / day, for children under 12 years old - 100-200 mcg / day. For the prevention of goiter in case of iodine deficiency: adults and children from 12 years old - 100-200 μg / day, children under 12 years old (including newborns) - 50-100 μg / day, pregnant and lactating women - 150-200 μg / day Prevention of relapse after therapeutic treatment of iodine-deficient goiter - 100-200 μg / day. After surgical treatment goiter in newborns, children and adolescents - 100-200 mcg / day. The duration of treatment is determined by the doctor; prophylactically for adults is usually prescribed for several months, years or a lifetime; children and adolescents - usually within 6-12 months.
Potassium iodide
Dosage form
pills
Composition of Potassium iodide Reneval in tablet form
Each tablet contains:
100 mcg tablets:
Active ingredient: Potassium iodide 131 mcg (corresponds to 100 mcg of iodine).
Excipients:
lactose monohydrate (milk sugar) - 0.059869 g
magnesium stearate - 0.001 g
croscarmellose sodium - 0.001 g.
Tablets 200 mcg:
Active ingredient: Potassium iodide 262 μg (corresponds to 200 μg of iodine).
Excipients:
magnesium hydroxycarbonate (basic magnesium carbonate) - 0.0175 g
lactose (milk sugar) - 0.059738 g
microcrystalline cellulose - 0.02 g
magnesium stearate - 0.001 g
colloidal silicon dioxide (aerosil) - 0.0005 g
croscarmellose sodium - 0.001 g
Description
Pills white, round, flat-cylindrical, chamfered, with or without "R" marking on one side.
Pharmacotherapeutic group
Thyroxine synthesis regulator - iodine drug
Pharmacodynamics of the drug
Iodine is one of the vital trace elements. Without iodine, the normal functioning of the thyroid gland is impossible, since it is an integral part of thyroxine and triiodothyronine. Thyroid hormones are involved in the development of all organs and systems, in the regulation metabolic processes in the body: protein, fat, carbohydrate and energy, they also regulate the activity of the brain, nervous and cardiovascular systems, genital and mammary glands, growth and development of the child, the formation of his intellectual abilities. Iodine deficiency is especially dangerous for children, adolescents, pregnant and lactating women.
Potassium iodide, being a source of iodine, replenishes its deficiency in the body, prevents the development of iodine deficiency diseases, prevents the development of goiter associated with a lack of iodine in food; normalizes the size of the thyroid gland in newborns, children, adolescents and adults.
Pharmacokinetics
When taken orally, the drug is almost completely absorbed in the small intestine. Average volume of distribution for healthy people is approximately 23 liters (38 % body weight). Plasma concentration of iodine is normally from 0.001 to 0.005 μg / ml. It accumulates in the thyroid gland, salivary glands, mammary glands and stomach tissues. The concentration in saliva, gastric juice and breast milk is approximately 30 times higher than in blood plasma. It is excreted by the kidneys, the concentration of iodine in the urine relative to creatinine (μg / g) is an indicator of its entry into the body.
Indications Potassium iodide Reneval in tablet form
Prevention of iodine deficiency diseases, incl. endemic goiter (especially in pregnant and lactating women);
Prevention of recurrence of goiter after it surgical removal or after completing treatment for goiter with thyroid hormone preparations;
Treatment of diffuse euthyroid goiter in newborns, children, adolescents and young adult patients.
Contraindications Potassium iodide Reneval in tablet form
Hyperthyroidism;
Subclinical hyperthyroidism when taking doses of iodine more than 150 mcg per day;
Dermatitis herpetiformis Duhring;
Solitary toxic adenomas of the thyroid gland and functional autonomy of the thyroid gland (focal and diffuse), nodular toxic goiter (except for preoperative therapy to block the thyroid gland);
Increased sensitivity to iodine.
Potassium iodide should not be taken in hypothyroidism, except in cases where the development of the latter is caused by severe iodine deficiency.
The administration of the drug should be avoided during therapy with radioactive iodine, in the presence or suspicion of thyroid cancer.
Since the drug contains lactose monohydrate, it is not recommended to prescribe it to patients with rare hereditary diseasesassociated with galactose intolerance, lactase deficiency or glucose-galactose malabsorption.
Pregnancy and lactation
During pregnancy and breastfeeding the need for iodine increases, therefore, it is especially important to use the drug Potassium iodide in sufficient doses to ensure an adequate intake of iodine in the body. The drug crosses the placenta and is excreted with breast milk... If a nursing woman is taking potassium iodide, additional administration of the drug to breastfed babies is not required.
The use of the drug during pregnancy and during breastfeeding is possible only in recommended doses.
When carrying out therapy, it is necessary to take into account the amount of iodine supplied with food.
Dosing and Administration Potassium iodide Reneval in tablet form
When determining the required dose of the drug, it is necessary to take into account the regional and individual characteristics of the intake of iodine with food. This is especially important when prescribing the drug to newborns and children under 4 years of age.
Prevention of iodine deficiency diseases:
Newborns and children: 50-100 mcg of iodine per day (1/2 - 1 tablet of the preparation Potassium iodide 100 mcg);
Adolescents and adults:
During pregnancy and during breastfeeding: 100-200 mcg of iodine per day (1 tablet of the preparation Potassium iodide 100 mcg or 1 tablet of the preparation Potassium iodide 200 mcg.
Prevention of recurrence of goiter after its surgical removal or after completion of treatment of goiter with thyroid hormone preparations:
100-200 mcg of iodine daily (1 tablet of the preparation Potassium iodide 100 mcg or 1 tablet of the preparation Potassium iodide 200 mcg).
Treatment for euthyroid goiter:
Newborns and children: 100-200 mcg of iodine per day (1 tablet of the preparation Potassium iodide 100 mcg or 1 tablet of the preparation Potassium iodide 200 mcg);
Adolescents and young adult patients: 200 mcg of iodine per day (2 tablets of the preparation Potassium iodide 100 mcg or 1 tablet of the preparation Potassium iodide 200 mcg).
The daily dose of the drug should be taken at one time, after meals, with a sufficient amount of liquid. When prescribing the drug to newborns and children under 3 years of age, it is recommended to dissolve the tablet in a small amount (1 tablespoon) of boiled water at room temperature.
The use of the drug for prophylactic purposes is carried out, as a rule, for several months or years, and often throughout life.
For the treatment of goiter in newborns, in most cases, 2-4 weeks are sufficient; in children, adolescents and adults, it usually takes 6-12 months or more. The duration of treatment is determined by the doctor.
Side effects of the medication
Allergic reactions can rarely occur: skin rash, Quincke's edema.
Overdose
When the drug is prescribed at a dose of more than 150 μg per day, patients with foci with functional autonomy in the thyroid gland may develop iodine-induced hyperthyroidism.
With therapy with high doses of iodine (more than 1,000 mcg per day), goiter and hypothyroidism caused by iodine may develop in some cases.
Chronic overdose can lead to the phenomenon of "iodism": a metallic taste in the mouth, edema and inflammation of the mucous membranes (rhinitis, conjunctivitis, gastroenteritis, bronchitis), acne, dermatitis, swelling of the salivary glands, fever, irritability.
Treatment: in case of chronic overdose, it is recommended to stop using the drug. With the development of iodine-induced hyperthyroidism, it is recommended to stop using the drug and prescribe therapy with antithyroid drugs. In severe cases, it is necessary to carry out intensive therapy, plasmapheresis or thyroidectomy. With the development of hypothyroidism, it is recommended to stop using the drug and prescribe therapy with iodine-containing thyroid hormones.
Interaction
The effectiveness of treatment with antithyroid medicines while taking iodine decreases.
Potassium perchlorate inhibits the absorption of iodine by the thyroid gland.
Taking high doses of iodine and the simultaneous administration of potassium-sparing diuretics can lead to the development of hyperkalemia.
The simultaneous appointment of high-dose iodine therapy with lithium preparations promotes the development of goiter and hypothyroidism.
The absorption of iodine by the thyroid gland and its metabolism are stimulated by thyroid-stimulating hormone.
special instructions
It should be borne in mind that against the background of drug therapy in patients with renal failure, hyperkalemia may develop.
Before starting therapy, it is necessary to exclude the presence of hyperthyroidism or nodular toxic goiter in the patient, as well as the presence of these diseases in the anamnesis.
In the presence of a predisposition to autoimmune thyroid diseases, the formation of antibodies to thyroid peroxidase is possible.
The saturation of the thyroid gland with iodine can inhibit the accumulation of radioactive iodine used for therapeutic or diagnostic purposes. In this regard, it is not recommended to take the drug before carrying out actions using radioactive iodine.
Impact on the ability to drive vehicles. Wed and fur.
Potassium iodide does not affect the ability to drive vehicles and use machinery.
Release form / dosage
Tablets 100 mcg and 200 mcg.
Storage conditions
In a dark place at a temperature not exceeding 25 ° C.
Keep out of the reach of children.
Shelf life
Do not use after the expiration date printed on the package.
Regular dyeing, insufficient fortified food, smoking, constant stress and other factors cause dullness, brittleness and hair loss. A nicotinic acid Bufus, also called niacin, vitamin B 3 or vitamin PP, helps to solve these problems. It expands the peripheral blood vesselslocated on the scalp, thereby increasing blood circulation, accelerates the delivery of oxygen and beneficial trace elements to the hair follicles, and also increases the efficiency of metabolism in the hair roots. This action of the drug allows you to stop hair loss and stimulate their increased growth. Thanks to the participation of niacin in maintaining the natural pigmentation of the hair, it is also able to prevent the appearance of premature gray hair.
Bufus packaging: protected nicotinic acid for hair
PFK Obnovlenie, which produces nicotinic acid in special transparent containers, develops the drug and its packaging in-house. Polymer containers, better known today as Bufus, are modern ampoules designed for the safest possible storage and use of medical products. For the production of Bufus and its filling, the specialists of the PFC "Obnovlenie" company use the patented BFS filling technology. By purchasing Bufus nicotinic acid, you can be sure of the quality of the drug. Because the spill of the drug into polymer containers occurs immediately after their manufacture. Polymer containers are not procured for future use, therefore the ingress of foreign substances into Bufus and its contamination is excluded.
In addition to quality, such modern polymer packaging also guarantees the authenticity of the purchased medication. While glass ampoules or plastic vials can be made in a handicraft environment, Bufus containers cannot be created without special equipment and technology. In addition, it is possible to re-fill such modern containers even with the help of the latest automated plants used in well-known medical industries, impossible.
Bufus also ensures the product is sealed. Polymer packaging is produced in the form of a single one-piece container, which, after sealing, becomes completely impervious to water, air and other environmental components. The niacin bufus for hair loses its production tightness only at the moment of opening.
It is easy and safe to open a preparation packed in a modern polymer container. It is enough to turn the lid of the ampoule with your fingers and Bufus is already open. You do not have to use a special file or cutting tools, without which it is impossible to print a glass ampoule. However, such ease of opening the package does not at all indicate its fragility. Bufus is very durable. Dropping the drug poured into such a container cannot damage the package or break its tightness.
Opening a polymer container is an absolutely safe process. Cuts and inhalation of glass dust generated at the time of unpacking conventional ampoules are excluded when using nicotinic acid packaged in Bufus.
Nicotinic acid Bufus: instructions for use
Renewal is intended for use by people with hair loss, dandruff, monilethrix (thinning and breakage of hair), and people who experience premature graying, brittle, split ends or lifeless hair. Nicotinic acid Bufus is also used for hair growth when alopecia areata, duffy and total baldness, observed in women and men.
The effectiveness of the drug is due to its multifunctionality. It improves scalp microcirculation, has anti-inflammatory effects, promotes keratin production and prevents hair cell DNA damage.
According to the instructions, nicotinic acid Bufus is applied as follows: once every three days, the contents of the 1st ampoule of the drug are applied to the previously washed wet hair. To do this, Bufus is opened and nicotinic acid is poured onto the scalp in small portions. After which the drug is gently rubbed with your fingers. Hair nicotinic acid (Bufus) is easy to use, no additional funds not needed for application. The course lasts 14 days, after which it stops for 3 months and can be repeated if necessary.
It should be remembered that the opened ampoule must be used immediately, otherwise the properties of niacin will be lost. Experts do not recommend using more than 2 ampoules during one procedure, since exceeding the allowable rate for application can cause allergic reaction on the drug. Nicotinic acid does not require rinsing.
To find out if you are prone to an individual intolerance to niacin, apply a few drops of the drug to your temple or the inside of your wrist. If you have a severe rash, itching, burning sensation, or headache, your body is not reacting to niacin, so you are not advised to use this drug. The formation of slight redness, accompanied by a tingling sensation in the wrist, is a natural reaction of the body to nicotinic acid, which indicates blood flow to the application site.
According to the instructions, the Renewal nicotinic acid in the Bufus container is contraindicated for persons with individual intolerance to vitamin B 3, suffering from hypertension, disorders of the vegetative-vascular system, headaches (including migraines), atherosclerosis, increased intracranial and ocular pressure, as well as children under 10 years of age. ...
Is bufus nicotinic acid effective for hair growth?
The effectiveness of niacin has been repeatedly demonstrated in the course of experiments conducted by foreign scientists. So a 2002 study proved the active work of niacin to improve hair structure. As a result of 14 procedures for applying a solution of nicotinamide to the scalp, the water loss previously carried out through the skin decreased by 24%, while the synthesis of ceramides increased by 34%.
Clinical studies of nicotinic acid have also shown the effectiveness of the drug for treating female alopecia (baldness). Despite the fact that niacin derivatives were applied to the scalp of the subjects, at the end of the six-month experiment, 32 out of 32 patients acquired healthy hair on previously bald areas of the head.