Cocarboxylase treatment. Cocarboxylase, powder for solution for injection (vials)

Cocarboxylase (cocarboxylase) is a vitamin-like enzyme used to regulate heat exchange within tissues and metabolism. The drug is widely used in medicine and is especially indispensable today during pregnancy. Cocorboxylase has a positive effect on fat and sugar metabolism, as well as on neuro-reflex reactions. Due to its use, an excellent assimilation of glucose by the body occurs, the work of the cardiovascular vascular system, and metabolic processes are accelerated.

With an insufficient amount of this substance, acidosis or prohibitive high level acidity in the blood, which adversely affects normal functions internal organs... The medicine is prescribed for toxicosis during pregnancy, since this is also a metabolic disorder.

In our body, this substance is formed as a result of the body's use of vitamin B1 or coffee. Coffee beverages are substances that accelerate many metabolic processes within the body several times, including participating in the process of carbohydrate metabolism. In the chemical connection between proteins and magnesium ions, this component is part of the enzyme carbroxylase, and it, in turn, provides an effect on the metabolism of carbohydrates and lowers the level of pyruvic and lactic acids, and also promotes the absorption of glucose by the body. All of the above ensures the efficiency of energy processes and metabolism in internal organs.

The presence of vitamin B1, which is present in the body, necessary for participation in biochemical processes, is indispensable for ensuring normal vital functions.

Benefits of cocarboxylase

Cocarboxylase is a ready-made form of the enzyme involved in important vital functions of the body, although not all properties coincide with the functions of vitamin B1.

The main feature of cocarboxylase is the complete assimilation of the drug in a fairly short period of time, but in the case when it is administered parenterally. Due to the speed active substance penetrates into all tissues, and its greatest concentration falls on the liver, brain and heart. Erythrocytes transport the drug into the blood in the form of thiamine diphosphate, and the metabolism of the active substance occurs in the liver. Completely the drug is excreted from the body along with urine.

It is known that cocarboxylase is recognized as the active form of vitamin B1. Due to the activation of tissue metabolism, the metabolic action of this substance occurs. The drug takes an active part in the carboxylation and decarboxylation of alpha-keto acids. Its main advantages include an improvement in the processes of carbohydrate metabolism, glucose uptake, a decrease in the level of pyruvic acid, as well as the normalization of tissue regeneration in the central and peripheral nervous system... After taking cocarboxylase in patients, the functionality of the cardiovascular system increases.

It is important to note that since the drug is a thiamine derivative, it is not suitable for the treatment of hypovitaminosis and vitamin B1 deficiency. The drug is completely excreted from the body along with urine, without being metabolized by the kidneys.

Cocarboxylase is used in the complex treatment of diseases associated with a lack of vitamin B1 and to improve carbohydrate metabolism. An insufficient level of cocarboxylase in the body can provoke the development of the pathology of acytosis, which in the future can affect the normal functioning of all internal organs, which can subsequently lead to a lethal outcome.

The list of pathologies for which the adoption of cocarboxylase is recommended:
acidosis;
heart and lung failure;
chronic diseases of the heart and blood vessels;
with ischemia, including in pre-infarction conditions;
hepatic and renal failure;
with a chronic disease of alcoholism;
with intoxication of the body;
in acute viral infections;
with pathologies of the nervous system;
if the brain is affected in a newborn and this is associated with oxygen starvation;
in case of violations associated with hydrocarbon exchange.

Harm from the use of cocarboxylase

There are no contraindications to the use of the drug, only if the person has an allergic reaction to the substance. However, if you do not follow the instructions for taking the drug, the following symptoms of an overdose may appear: nausea, weakness, muscle spasms, increased sweating, irregular heart rhythms, headaches, fatigue and shortness of breath, Quincke's edema and hypertension.

For the treatment of pathologies associated with a lack of vitamin B1, cocarboxylase is not prescribed.

In the event of health deviations due to an overdose of the drug, treatment is carried out aimed at ensuring the normal functioning of the heart muscle and lungs.

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Cocarboxylase is a drug that has a metabolic effect and activates tissue metabolism.

Pharmacological action of Cocarboxylase

Cocarboxylase is a coenzyme of enzymes that are involved in the metabolism of carbohydrates. Exogenous cocarboxylase is formed during the metabolism of thiamine.

The drug takes an active part in the processes of decarboxylation of alpha-keto acids. In addition, the drug affects the pentose phosphate pathway of glucose breakdown. Cocarboxylase improves the absorption of glucose, while reducing the level of lactic acid in the body, improves the trophism of the tissues of the peripheral, as well as the central nervous system. In addition, the drug affects work of cardio-vascular system.

According to the instructions, Cocarboxylase is used for the treatment of vitamin B1 hypo - and vitamin deficiency. The drug is excreted from the body by the kidneys.

Method of administration and dosage

The medicinal product is intended for the preparation of a solution for parenteral use... According to the instructions, Cocarboxylase must be diluted in 2 milliliters of water for injection. The drug should be dissolved immediately before injection.

Solution for injection can be administered in several ways: intramuscularly, subcutaneously and intravenously. The duration of treatment and doses are prescribed individually for each patient.

• According to the instructions, adults are prescribed 50-100 milligrams intramuscular injection 1 per day.
• If an adult has a serious condition, experts prescribe 50-100 milligrams every 2 hours. Injections are administered intramuscularly. After that, it is necessary to switch to a maintenance dose of 50-100 milligrams.
• It is advisable to use Cocarboxylase for children under the age of 3 months in the form of subcutaneous administration drug. The dose is 25 milligrams once a day.
• For children, whose age is from 4 months to 7 years, experts prescribe a subcutaneous or intramuscular injection of a solution of 25-50 milligrams 1 time per day.
• For children over 8 years old, it is recommended to inject 50-100 milligrams of the drug intramuscularly once a day.

If necessary, specialists can share daily dose Cocarboxylase for two administrations.

Indications for use

The drug is prescribed to patients who suffer from hepatic, renal failure, hepatic coma. In addition, Cocarboxylase is prescribed as a therapy for precomatous conditions.

Cocarboxylase should be used in patients who have acidosis against the background of diabetes mellitus, as well as people suffering from respiratory acidosis with pulmonary heart failure.

The drug is indicated for multiple sclerosis, with heart disease, with atrial fibrillation, with paroxysmal tachycardia. Cocarboxylase is also prescribed for neuritis, as well as for pathologies associated with impaired carbohydrate metabolism.

Application during pregnancy

Cocarboxylase during pregnancy is allowed to be prescribed if the expected benefit to the woman significantly outweighs the potential risks to the child. If it is necessary to use the drug during lactation, you should consult with a specialist and decide on the interruption breastfeeding baby.

Cocarboxylase during pregnancy, if pathologies in the development of the fetus are observed, it is strictly forbidden to prescribe.

Contraindications

The drug should not be prescribed when hypersensitivity to cocarboxylase hydrochloride. According to reviews, Cocarboxylase can cause allergic reactions on the skin, including itching and redness. The formation of urticaria is not excluded.

The drug should not be prescribed to patients with atrial fibrillation. According to reviews, Cocarboxylase can cause skin redness, itching and tissue swelling at the injection site.

Overdose

In case of an overdose of the drug, the severity of side effects may increase, and violations of the respiratory or cardiovascular systems may also occur.

According to reviews, Cocarboxylase has no specific antidote. In case of an overdose, the drug should be canceled and symptomatic therapy should be carried out, as well as measures to maintain the functions of the respiratory and cardiovascular systems.

Interaction with other drugs

According to reviews, Cocarboxylase, when combined, enhances therapeutic effects cardiac glycosides.

According to the instructions, it is strictly prohibited to mix the drug in one syringe with other drugs. It is permissible to use only the solvent that is in the box with the drug.

Conditions and shelf life

The shelf life of the medicinal product is 3 years. After the solution has been prepared, it must be used immediately. According to reviews, Cocarboxylase should be stored away from children, in a dry and dark place.

It is necessary to store the drug at a temperature not exceeding 25 degrees Celsius.

Composition

One bottle of powder contains: cocarboxylase hydrochloride - 50 milligrams and excipients.

One ampoule with solvent contains: water for injection - 2 milligrams.

The use of Cocarboxylase reduces the concentration of pyruvic and lactic acid, improves glucose processing, has a positive effect on the trophism of nerve tissues, and normalizes the functionality of the cardiovascular system. If the body is deficient in this substance, the level of pyruvic acid in the blood rises, which can lead to the development of acidosis.

Release form and composition

Pharmacological action - coenzyme, metabolic. Pharmacological group - enzymes / metabolics, vitamin-like agents, vitamins.

Indications for use and price

The average price of cocarboxylase in ampoules and vials is 110-115 rubles. you can buy cocarboxylase at pharmacies.

Cocarboxylase application and indications:

• Diabetic, metabolic, respiratory acidosis(failures of the acid-base state, they appear as low rate blood pH and bicarbonate concentrations below normal.
• Hypoglycemia, hyperglycemia (high and low sugar levels).
• Pathological processes in the body, accompanied by disorders of carbohydrate metabolism. Diseases of this group can be hereditary and acquired. The most common are galactosemia, generalized glycogenosis, diabetes mellitus.
• Hepatic, respiratory, renal, heart failure. Relevant for acute and chronic forms of diseases.
• Postinfarction cardiosclerosis- as a component complex treatment cardiovascular diseases, in more detail on).
• Hepatic coma.
• Diabetic coma. (Very often occurs as a result of violations)
• Chronic alcoholism and acute poisoning alcohol.
• Poisoning with drugs of the barbiturate group, digitalis.
• Paratyphoid fever, scarlet fever, diphtheria, typhus - as a component complex therapy.
• Multiple sclerosis, peripheral neuropathy.
• Hypoxic perinatal encephalopathy, pneumonia, sepsis, respiratory failure in newborns.
• Conditions accompanied by acidosis and hypoxia.

Cocarboxylase is a proven vitamin preparation. It is often used as an integral part of complex therapy. It almost does not cause adverse reactions... When undergoing a course of treatment, it is necessary to prepare for the fact that the injections are painful.

Instructions for use and doses

Instructions for the use of cocarboxylase injections and powders for solution preparation:

• The drug Cocarboxylase is administered subcutaneously, intramuscularly or intravenously. The proportion of the drug is prescribed individually, based on the anamnesis, the patient's condition and the severity of the disease.
• For adults, the drug is administered once - 50/100 mg. If necessary, as in the case of a diabetic coma - every two to three hours. In the future, the prescribed therapy is maintained - 50 mg daily.
• With stable circulatory failure - strictly 50 mg two to three times daily, before taking digitalis drugs. The course of procedures is 15-30 days.
• With diabetes mellitus - 100-1000 mg daily with a duration of 5-10 days, without stopping the standard antidiabetic therapy.
• At acute form renal or liver failure, burns, intoxications 50-150 mg three times a day.
• With multiple sclerosis and peripheral neuritis 50/100 mg daily for 30-45 days.

Contraindications

• High sensitivity to the drug.
• Vitamin B1 hypovitaminosis.
• Vitamin B1 deficiency.

During pregnancy and children

For children, the drug is administered intramuscularly or subcutaneously, except for newborn babies. The drug is administered to them sublingually.

These doses can be administered in two divided doses.

The drug "Cocarboxylase" during pregnancy

The remedy can be prescribed as prescribed by a doctor in several cases:

• Severe toxicosis. In such conditions, there are widespread metabolic disorders. The drug helps to improve carbohydrate metabolism, significantly stabilizing the woman's condition. It is usually prescribed as part of a comprehensive treatment for toxicosis.
• Placental insufficiency... Doctors most often prescribe a ten-day course of injections, when the drug is injected intravenously. As a result, the placental nutrition of the fetus is stabilized, and the uterine circulation is improved.

Contraindications during pregnancy

• Increased susceptibility to the drug.
• Propensity to develop allergic reactions.

How to prevent cocarboxylase deficiency during pregnancy

The drug is an active form of vitamin B 1, therefore, in order to avoid deficiency, it is recommended to consume foods with a high content of this substance: liver, cereals - buckwheat and oatmeal, pork, veal, cauliflower.

Cocarboxylase is a metabolite, an enzyme of natural origin. However, safety during pregnancy has been proven only theoretically, not one hundred percent. Not a single long-term study has been carried out on this score.

Overdose and side effects

• Held symptomatic treatment, aimed at stabilizing cardiovascular activity and respiratory rhythm.
• Cancellation of the drug.

As a rule, an overdose does not occur.

• Itching, urticaria and others
• In the case of intramuscular injection, there is swelling and itching at the injection site.

Analogs

• Ferein cocarboxylase.
• "Impruv cocarboxylase".
• “Cocarboxylase hydrochloride”.
• Ellara cocarboxylase.

All drugs have exactly the same active ingredient and release form.

Cocarboxylase and ATP

1. Therapy of tuberculosis in children of early and adolescence. Doctors often refer to the means of pathogenetic therapy as those drugs that stimulate energy metabolism. scientific research has made it possible to establish that under the influence of tuberculosis intoxication or in oncology in the case of prolonged chemotherapy, unfavorable shifts develop in energy metabolic processes, in particular, in the heart muscle. With the development of pulmonary tuberculosis, hypoxia occurs, which leads to an increase in anaerobic glycolysis. As a result, under-oxidized products accumulate; therefore, it is advisable to use cocarboxylase and ATP in the complex treatment of patients.
2. The drug has a positive effect on internal metabolic processes, has a beneficial effect on myocardial trophism. When combining anti-tuberculosis drugs with cocarboxylase and ATP, the symptoms of intoxication disappear much faster. The course is usually formed by 10-15 injections, depending on the severity of the disease.
3. With multiple sclerosis the alternation of cocarboxylase and ATP injections becomes part of the complex therapy.

A cardiovascular agent, the main active ingredient of which is referred to as cocarboxylase. In the human body, "Cocarboxylase" is formed from Thiamine and takes part in carbohydrate and fat metabolism. Promotes the synthesis of acetyl coenzyme A.

Reviews:

Maria Mikhailovna 33 years old

I had a very strong and exhausting toxicosis, my weight decreased by 6 kg, the doctor considered it necessary to prescribe cocarboxylase. The drug was administered intravenously and the suffering was relieved after just ten injections. Then a healthy baby was born.

Victor Fedorovich 47 years old

I was prescribed the drug after suffering a cardiovascular disease. There were no significant changes, but the doctor said that there is a positive trend.

In this article, you can read the instructions for use medicinal product Cocarboxylase... Feedback from website visitors - consumers are presented of this medicine, as well as the opinions of medical specialists on the use of Cocarboxylase in their practice. A big request to actively add your reviews about the drug: did the medicine help or did not help get rid of the disease, what complications were observed and side effects, possibly not declared by the manufacturer in the annotation. Analogs of Cocarboxylase in the presence of available structural analogs. Use for the treatment of acidosis, diabetic coma and hepatic and renal failure in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Cocarboxylase- a coenzyme formed in the body from thiamine. Has a metabolic effect, activates tissue metabolism. In the body, it is phosphorylated to form mono-, di- and triphosphoric esters; cocarboxylase is a part of enzymes that catalyze carboxylation and decarboxylation of keto acids, pyruvic acid, promotes the formation of acetyl coenzyme A, which determines its participation in carbohydrate metabolism. Participation in the pentose cycle indirectly promotes the synthesis of nucleic acids, proteins and lipids.

Improves the absorption of glucose, trophism of the nervous tissue, helps to normalize the functions of the cardiovascular system.

Cocarboxylase deficiency causes an increase in the level of pyruvic and lactic acids in the blood, which leads to acidosis and acidotic coma.

Composition

Cocarboxylase hydrochloride + excipients.

Indications

• metabolic acidosis;
• hyperglycemic coma and acidosis in diabetes mellitus;
• liver failure;
• renal failure;
• respiratory acidosis in chronic, cardiopulmonary insufficiency;
• respiratory failure;
• chronic circulatory failure;
• myocardial infarction and postinfarction cardiosclerosis (as part of complex therapy);
• acute alcohol poisoning;
• chronic alcoholism;
• poisoning with digitalis drugs, barbiturates;
• intoxication with infectious diseases: diphtheria, scarlet fever, typhoid and paratyphoid fever (in complex therapy);
• peripheral neuritis.

In children during the neonatal period:

• perinatal hypoxic encephalopathy;
• respiratory failure;
• pneumonia;
• sepsis;
• hypoxia;
• acidosis.

Forms of issue

Lyophilisate for the preparation of a solution for intravenous and intramuscular administration (injections in ampoules for injection).

Others dosage forms, be it pills or suppositories, does not exist.

Instructions for use and scheme of use

For adults, it is administered intramuscularly or intravenously. The dose is 50-200 mg per day. In diabetes mellitus (acidosis, coma), the daily dose may be 0.1-1 g. The frequency and duration of use depends on the indications.

For children - intramuscularly, intravenously (drip (dropper) or jet), newborns - sublingually. Children under 3 months old - 25 mg per day, from 4 months to 7 years old - 25-50 mg per day, from 8 to 18 years old - 50-100 mg per day. The duration of treatment is from 3-7 to 15 days.

Side effect

• allergic reactions (urticaria, itching);
• hyperemia, itching and swelling at the injection site.

Contraindications

• hypersensitivity to cocarboxylase.

Application during pregnancy and lactation

Medical research has not yet been conducted regarding the efficacy and safety of using cocarboxylase during pregnancy. Therefore, there is no reliable data on the contraindication of cocarboxylase at this time. A doctor's consultation is required.

Application in children

Application is possible according to the dosage regimen.

special instructions

Without features.

Drug interactions

Strengthens the cardiotonic action of cardiac glycosides and improves their tolerance.

Analogues of the drug Cocarboxylase

Structural analogs for active substance:

• Cocarboxylase Improv;
• Cocarboxylase Ferein;
• Ellara cocarboxylase;
• Cocarboxylase hydrochloride.

Analogs on pharmacological group(drugs for the treatment of acidosis):

• Alpha D3 Teva;
• Dimephosphone;
• Kalinor;
• Quintasol;
• Sodium bicarbonate;
• Compound sodium lactate;
• Stylamine;
• Trometamol N.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and see the available analogues for the therapeutic effect.

Cocarboxylase is a substance derived from vitamin B1. This substance plays a very important role in the human body, in particular, it participates in neuro-reflex reactions, as well as in the process of sugar and fat metabolism... If there is a deficiency of this substance in the body, serious disorders can develop. In particular, acidosis may develop, in which the acidity of the blood is greatly increased. This condition, in turn, causes disruption in the functioning of most systems and internal organs.

Additional application allows you to eliminate Cocarboxylase deficiency, activate metabolism, improve heart function, prevent disruption of many internal organs and systems. In addition, this remedy is often prescribed to pregnant women to relieve symptoms of toxicosis.

When and under what circumstances is cocarboxylase prescribed, instructions, use, indications, analogs, composition of the drug, which ones? To find out all this, let's read the instructions that are always attached to the medicine. So what is she talking about:

What is the composition of the drug Cocarboxylase?

The drug is produced in the form of a powder in a glass ampoule. A solution for injection is prepared from the powder. It contains 50 mg of the main active substance - cocarboxylase.

What are the analogues of Cocarboxylase?

This tool has structural analogs, which contain one active substance. These means include: Cocarboxylase (Impruv, Ferein, Ellara).

What are the indications for the drug Cocarboxylase?

The drug Cocarboxylase instructions for use are allowed to be used in the following cases:

In the presence of acidosis caused by impaired metabolic processes... With acidosis caused by pulmonary heart, respiratory failure, including treating newborn babies.

Cocarboxylase is prescribed for ischemia, with renal, hepatic insufficiency. In addition, the drug is used in the treatment of cardiovascular insufficiency, as well as in various poisonings, including intoxication of the body. medicines.

The drug is included in the treatment of chronic alcoholism, in the treatment of pathologies that have arisen due to a violation of the metabolism of carbohydrates. Prescribed for the treatment of newborns when their disease is associated with oxygen deprivation.

What is the use of the drug Cocarboxylase, dosage?

Cocarboxylase solution is intended for intramuscular administration, or intravenous administration... To prepare a solution, the powder in an ampoule (0.025 or 0.05) is dissolved in water for injection (2 ml).

For intravenous jet injection of the drug, you need to increase the volume to 10-20 ml. If necessary, drip volume is adjusted to 200-400 ml by adding sodium chloride to an isotonic solution. Or add glucose to the injection solution.

The dosage of administration is set by the doctor treating the disease. The dosage regimen directly depends on the severity of the pathology, the age and condition of the patient.

When carrying out complex treatment, Cocarboxylase is used:

Adults:

Heart disease: the usual daily dose is 1-0.2 g intramuscularly. Treatment for 15-30 days.

Acute hepatic, renal failure: the usual daily dose is 0.1-0.15 g. The dose is divided into three injections. Administered intravenously (jet). Treatment for 15-30 days. At drip- the powder is diluted in a 5% glucose solution. Introduction of 0.1-0.15 g per day.

Peripheral neuritis: daily dose 0.05-0.1 g intramuscularly. Treatment 1-1.5 months.

Diabetic coma: In coma, 50-100 mg of the drug is injected immediately. Re-enter not earlier than after 1-2 hours. After that, supportive treatment is applied using a dosage of 50 mg per day.

-: 50 mg of the drug solution is administered, 2-3 times a day. Introduction - 2 hours before using the drug foxglove.

Children:

Children receive the medicine intramuscularly and intravenously. The dosage depends on the severity of the pathology, its clinical manifestations... Usually, a daily dose of 25-50 mg is prescribed, divided into several applications. The duration of treatment is from 3 to 7 days, or from 15 to 30 days. Newborn children receive the drug intravenously, slowly. The dosage is 10 mg per 1 kg of the child's weight. Application once a day.

What are the side effects of Cocarboxylase?

The drug is usually well tolerated. But sometimes allergic manifestations can be observed. In the case of intramuscular injection, itching may be felt at the injection site, redness and swelling of the skin is observed.

What are the contraindications for Cocarboxylase?

There is only one contraindication - the special sensitivity of the body to Cocarboxylase.

Remember that this remedy should only be prescribed by a doctor. Treatment is carried out with regular medical supervision. Therefore, do not prescribe medication on your own. Self-medication never goes away without negative consequences. Keep this in mind and be healthy!