Application of captopril FPO at high pressure. Indications for use Captopril, at what pressure

In this article, you can read the instructions for using the drug Captopril... Feedback from website visitors - consumers are presented of this medicine, as well as the opinions of doctors of specialists on the use of Captopril in their practice. A big request is to actively add your reviews about the drug: did the medicine help or did not help get rid of the disease, what complications were observed and side effects, possibly not declared by the manufacturer in the annotation. Analogs of Captopril in the presence of available structural analogs. Use for treatment arterial hypertension and lowering pressure in adults, children, as well as during pregnancy and lactation.

Captopril - antihypertensive agent, ACE inhibitor. The mechanism of antihypertensive action is associated with competitive inhibition of ACE activity, which leads to a decrease in the rate of conversion of angiotensin 1 to angiotensin 2 (which has a pronounced vasoconstrictor effect and stimulates the secretion of aldosterone in the adrenal cortex). In addition, captopril appears to have an effect on the kinin-kallikrein system, preventing the breakdown of bradykinin. The antihypertensive effect does not depend on the plasma renin activity; a decrease in blood pressure is noted at normal and even reduced hormone concentration, which is due to the effect on the tissue RAAS. Increases coronary and renal blood flow.

Due to the vasodilating action, it reduces the OPSS (afterload), the pressure of wedging in the pulmonary capillaries (preload) and resistance in the pulmonary vessels; increases cardiac output and exercise tolerance. With prolonged use, it reduces the severity of left ventricular myocardial hypertrophy, prevents the progression of heart failure and slows down the development of left ventricular dilatation. Helps reduce sodium in patients with chronic heart failure. Expands arteries more than veins. Improves blood supply to the ischemic myocardium. Reduces platelet aggregation.

Reduces the tone of the efferent arterioles of the kidney glomeruli, improving intraglomerular hemodynamics, and prevents the development of diabetic nephropathy.

Pharmacokinetics

After oral administration, at least 75% is rapidly absorbed from the gastrointestinal tract. Simultaneous food intake reduces absorption by 30-40%. Protein binding, mainly albumin, is 25-30%. Excreted in breast milk. It is metabolized in the liver with the formation of the disulfide dimer of captopril and captopril-cysteine \u200b\u200bdisulfide. The metabolites are pharmacologically inactive. More than 95% is excreted by the kidneys, 40-50% unchanged, the rest in the form of metabolites.

Indications

• arterial hypertension (including renovascular);
• chronic heart failure (as part of combination therapy).

Release forms

Tablets 12.5 mg, 25 mg and 50 mg.

Instructions for use and dosage

Captopril is prescribed one hour before meals. The dosage regimen is set individually. To ensure the following dosing regimen, it is possible to use the drug Captopril in dosage form: tablets 12.5 mg.

In case of arterial hypertension, the drug is prescribed in an initial dose of 25 mg 2 times a day. If necessary, the dose is gradually increased (with an interval of 2-4 weeks) until the optimal effect is achieved. For mild or moderate arterial hypertension, the usual maintenance dose is 25 mg 2 times a day; the maximum dose is 50 mg 2 times a day. In severe arterial hypertension, the maximum dose is 50 mg 3 times a day. The maximum daily dose is 150 mg.

For the treatment of chronic heart failure, captopril is prescribed in cases where the use of diuretics does not provide an adequate effect. The initial dose is 6.25 mg 2-3 times a day, which is then gradually (with an interval of at least 2 weeks) increased. The average maintenance dose is 25 mg 2-3 times a day. In the future, if necessary, the dose is gradually increased (with an interval of at least 2 weeks). The maximum dose is 150 mg per day.

In old age, the dose of Captopril is selected individually, it is recommended to start therapy with a dose of 6.25 mg 2 times a day and, if possible, maintain it at this level.

If necessary, additional loop diuretics are prescribed, rather than thiazide diuretics.

Side effect

• pronounced decrease blood pressure;
• tachycardia;
• orthostatic hypotension;
• peripheral edema;
• proteinuria;
• impaired renal function (increased levels of urea and creatinine in the blood);
• neutropenia, anemia, thrombocytopenia, agranulocytosis;
• dizziness;
• headache;
• paresthesia;
• drowsiness;
• visual impairment;
• feeling tired;
• asthenia;
• dry cough that disappears after discontinuation of the drug;
• bronchospasm;
• pulmonary edema;
• angioneurotic edema of the limbs, face, lips, mucous membranes, tongue, pharynx and larynx;
• serum sickness;
• lymphadenopathy;
• a rash, usually maculopapular in nature, less often of a vesicular or bullous nature;
• increased photosensitivity;
• violation of taste;
• dry mouth;
• stomatitis;
• nausea;
• decreased appetite;
• diarrhea;
• stomach ache.

Contraindications

• angioedema, incl. hereditary, history (including history after using other ACE inhibitors);
• severe renal dysfunction, azotemia, hyperkalemia, bilateral renal artery stenosis or stenosis of a single kidney with progressive azotemia, condition after kidney transplantation, primary hyperaldosteronism;
• aortic stenosis, mitral stenosis, the presence of other obstacles to the outflow of blood from the left ventricle of the heart;
• severe liver dysfunction;
• arterial hypotension;
• cardiogenic shock;
• pregnancy and lactation;
• age up to 18 years (efficacy and safety in children have not been established).
• hypersensitivity to captopril and other ACE inhibitors.

special instructions

Renal function should be monitored before starting, as well as regularly during treatment with captopril.

In chronic heart failure, the drug is used subject to careful medical supervision.

Captopril is prescribed with extreme caution in patients with diffuse diseases. connective tissue or systemic vasculitis; patients receiving immunosuppressive drugs, especially in the presence of impaired renal function (risk of developing serious infections that do not respond to antibiotic therapy). In such cases, the peripheral blood picture should be monitored before using captopril, every 2 weeks during the first 3 months of therapy, and periodically during the subsequent period of treatment.

The drug is used with caution against the background of treatment with allopurinol or procainamide, as well as against the background of treatment with immunosuppressants (including azathioprine, cyclophosphamide), especially in patients with impaired renal function.

Use with caution in patients with a history of kidney disease, as the risk of proteinuria increases. In such cases, during the first 9 months of treatment with captopril, the amount of protein in the urine should be monitored monthly. If the level of protein in the urine exceeds 1 g per day, it is necessary to decide on the advisability of further use of the drug. Captopril should be used with caution in patients with renal artery stenosis. there is a risk of developing renal dysfunction; in case of an increase in the level of urea or creatinine in the blood, it may be necessary to reduce the dose of captopril or discontinue the drug.

When carrying out hemodialysis in patients receiving captopril, the use of dialysis membranes with high permeability (including AN69) should be avoided. this increases the risk of developing anaphylactoid reactions.

The likelihood of developing arterial hypotension during treatment can be reduced if, 4-7 days before starting treatment with captopril, the use of diuretics is stopped or their dose is significantly reduced.

If symptomatic arterial hypotension occurs after taking captopril, the patient should take a horizontal position with raised legs.

In the case of severe arterial hypotension, a positive effect is noted with intravenous administration isotonic sodium chloride solution.

In the event of the development of angioedema, the drug is canceled and careful medical supervision is carried out. If the swelling is localized on the face, special treatment usually not required (antihistamines may be used to relieve symptoms); in the event that the edema spreads to the tongue, pharynx or larynx and there is a threat of developing obstruction respiratory tract, you should immediately inject epinephrine (adrenaline) subcutaneously (0.5 ml at a dilution of 1: 1000).

Influence on the ability to drive vehicles and use mechanisms

During the period of treatment with captopril, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions, because dizziness is possible, especially after taking the initial dose.

Drug interactions

Diuretics and vasodilators (eg, minoxidil) potentiate the hypotensive effect of captopril.

With the combined use of captopril with indomethacin (and, possibly, with other non-steroidal anti-inflammatory drugs (NSAIDs)), a decrease in the hypotensive effect may be observed.

The hypotensive effect of captopril can be reduced by estrogen (Na + retention).

The antihypertensive effect of captopril may be delayed when administered to patients receiving clonidine.

Simultaneous use with potassium-sparing diuretics or potassium preparations can lead to hyperkalemia.

With the simultaneous use of lithium salts, an increase in the concentration of lithium in the blood serum is possible.

The use of captopril in patients taking allopurinol or procainamide increases the risk of neutropenia and / or Stevens-Johnson syndrome.

The use of captopril in patients taking immunosuppressive drugs (for example, cyclophosfacin or azathioprine) increases the risk of developing hematological disorders.

With the simultaneous use of ACE inhibitors and gold preparations (sodium aurothiomalate), a symptom complex is described, including facial flushing, nausea, vomiting and a decrease in blood pressure.

Concomitant use of insulin and oral hypoglycemic medicines increases the risk of developing hypoglycemia.

Analogues of the drug Captopril

Structural analogues for the active substance:

• Alcadil;
• Angiopril-25;
• Blockordil;
• Vero Captopril;
• Kapoten;
• Captopril Hexal;
• Captopril Sandoz;
• Captopril AKOS;
• Captopril Acri;
• Captopril Sar;
• Captopril STI;
• Captopril UBF;
• Captopril Ferein;
• Captopril FPO;
• Captopril Egis;
• Catopil;
• Epsitron.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and see the available analogues for the therapeutic effect.

Captopril

International non-proprietary name

Captopril

Dosage form

Tablets 25 mg

Composition

One tablet contains

active substance -captopril 25 mg,

excipients:lactose monohydrate, microcrystalline cellulose, magnesium or calcium stearate, colloidal anhydrous silicon dioxide

Description

Pills white, flat-cylindrical, chamfered on both sides, with a cross-shaped line on one side and engraving “G” on the other.

Pharmacotherapeutic group

Drugs affecting the renin-angiotensin system.

Angiotensin converting enzyme (ACF) inhibitors. ACF inhibitors. Captopril.

ATX code С09АА01

Pharmacological properties

Pharmacokinetics

After oral administration, it is rapidly and completely absorbed from the gastrointestinal tract. Simultaneous food intake reduces absorption by 30-55%. The maximum concentration (Cmax) in blood plasma is reached after 30-90 minutes. In blood plasma, it binds to proteins by 25-30%. It is widely distributed throughout all organs and tissues, penetrates the placenta, into breast milkdoes not pass the blood-brain barrier. It is metabolized in the liver with the formation of the disulfide dimer of captopril and captopril-cysteine \u200b\u200bdisulfide. The half-life is 2-3 hours. Excreted by the kidneys 40-50% unchanged, the rest in the form of metabolites.

Pharmacodynamics

Captopril has a hypotensive, vasodilating, cardioprotective effect. Inhibits the activity of the angiotensin-converting enzyme, which leads to a decrease in the rate of conversion of angiotensin I to angiotensin II (has a vasoconstrictor effect, promotes the release of aldosterone) and prevents the inactivation of endogenous dilators - bradykinin and prostaglandin E2. Increases the activity of the kallikrein-kinin system, increases the release biologically active substances, which have a natriuretic and vasodilator effect, improve renal blood flow. Reduces the total peripheral vascular resistance, pre- and afterload on the heart, pressure in the small circle and in the pulmonary capillaries, increases cardiac output.

Indications for use

arterial hypertension (mono- and combination therapy)

chronic heart failure (as part of a combined

dysfunction of the left ventricle in a stable condition in

patients after myocardial infarction

diabetic nephropathy associated with type I diabetes mellitus

Method of administration and dosage

The drug is taken orally, regardless of food intake.

Arterial hypertension

The initial dose is 25-50 mg 2 times a day, if necessary, a single dose is increased to 100-150 mg 2 times a day, with an interval of 2-4 weeks. The maintenance dose is 25 mg 2-3 times a day. The maximum daily dose is 150 mg.

Chronic heart failure

The initial dose is 6.25-12.5 mg 2 - 3 times a day, followed by an increase every 2-3 weeks, up to a maintenance dose of 25 mg 2-3 times a day or up to 50 mg 3 times a day. The maximum daily dose is 150 mg.

Left ventricular dysfunction

Treatment usually begins between the 3rd and 16th days after myocardial infarction. The initial dose of captopril is 6.25 mg / day on the first day. Then, the next day, it increases to 12.5 mg three times a day for two days, with a gradual increase to 25-50 mg captopril three times a day. This dose is achieved gradually over several weeks. In case of symptomatic hypotension, such as in heart failure, the dose of diuretics and / or other concomitant vasodilators may be reduced in order to achieve a steady state dose of captopril.

The maximum daily dose is 150 mg.

Diabetic nephropathy in insulin-dependent diabetes mellitus

The starting dose is 6.25 mg / day. If necessary, the dose is increased to 75-100 mg / day (in 2-3 doses). In insulin-dependent diabetes with microalbuminuria (release of albumin 30-300 mg per day), the dose of the drug is 50 mg twice a day. With a total protein clearance of more than 500 mg per day, the drug is effective at a dose of 25 mg three times a day.

With impaired renal function

The initial dose is 6.25 mg 2-3 times a day, followed by an increase. The maximum dose depends on creatinine clearance.

The duration of treatment is determined by the attending physician in each case, depending on the pathology.

Elderly patients

In elderly patients, the initial dose is 6.25 mg twice a day. For elderly patients, the dose of the drug is selected individually, taking into account the possibility of impaired renal function or other organs.

Side effects

Often

dizziness, sleep disturbances

dry mouth, impaired taste (metallic or

salty taste, disappearing on its own 2-3 months after

initiation of treatment), nausea, vomiting, abdominal pain, diarrhea, constipation

hyponatremia

dry cough, shortness of breath

skin rash, itching

alopecia

Infrequently

tachycardia, palpitations, chest pain, tachyarrhythmia, angina

arterial hypotension, Raynaud's syndrome, hot flashes

pallor skin

feeling tired, asthenia

Seldom

anorexia

renal failure, polyuria, oliguria, proteinuria, urinary frequency

headache, drowsiness, paresthesia

stomatitis, aphthous ulcers oral mucosa

quincke's edema

Very rarely

nephrotic syndrome

neutropenia, agranulocytosis, pancytopenia, anemia, thrombocytopenia, leukopenia, lymphadenopathy, eosinophilia, leukopenia, positive antinuclear antibody titer, increased ESR

hyperkalemia, hypoglycemia

bronchospasm, rhinitis, allergic alveolitis / eosinophilic pneumonia

glossitis, stomach ulcer, pancreatitis

impaired liver function, cholestasis, jaundice, hepatitis, hepatic cell necrosis, increased levels of hepatic transaminases, bilirubin

angioedema, stevens-Johnson syndrome, erythema multiforme, photosensitivity, exfoliative dermatitis, erythroderma, pemphigus

myalgia, arthralgia

impotence, gynecomastia

confusion, depression

violation of cerebral circulation, including stroke and fainting

visual impairment

cardiac arrest, cardiogenic shock

hives

nephrotic syndrome

fever

Contraindications

hypersensitivity to drug components

a history of angioedema or other vascular edema (eg, due to previous therapy with ACE inhibitors)

renal artery stenosis (bilateral or unilateral with one kidney)

condition after kidney transplant

hemodynamically significant stenosis of the aorta or mitral valve or, hypertrophic cardiomyopathy

primary hyperaldosteronism

hyperkalemia, progressive arrhythmia

pregnancy and lactation

childhood under 18

hereditary fructose intolerance, deficiency of the enzyme Lap-lactose, malabsorption of glucose-galactose

low-density lipoprotein apheresis with dextran sulfate (life-threatening anaphylactoid reactions may develop)

desensitizing therapy against insect poisons (life-threatening anaphylactoid reactions may develop - drop in blood pressure, choking, vomiting, allergic skin reactions)

dialysis using polyacrylonitrile-metal-sulfonate membranes with high permeability (for example, "AN 69") due to the risk of developing anaphylactoid reactions (hypersensitivity reactions), up to shock

combined use with aliskiren-containing drugs in patients with diabetes mellitus or chronic renal failure (GFR less than 60 ml / min).

Captopril can be used only after a very careful comparison of the possible benefits and risks in conditions of regular monitoring of clinical and laboratory parameters in:

severe renal impairment (creatinine clearance less than 30 ml /

• clinically significant proteinuria (more than 1 g / day)

  clinically significant disorders electrolyte balance

  primary disease liver or liver failure

  impaired immune response or collagen diseases (eg, systemic lupus erythematosus, scleroderma)

  simultaneous systemic therapy with drugs that suppress protective reactions (for example, corticoids, cytostatics, antimetabolites), allopurinol, procainamide or lithium.

Drug interactions

With the simultaneous use of Captopril with potassium-sparing diuretics, potassium preparations, hyperkalemia may develop. Diuretics, vasodilators, anesthetics enhance the hypotensive effect of Captopril.

With simultaneous use with non-steroidal anti-inflammatory drugs, a decrease in the antihypertensive effect is possible, as well as the manifestation of an additive effect on an increase in potassium in serum, while renal function may decrease. These effects are reversible. However, in rare cases, acute renal failure is possible in patients with impaired renal function and in elderly patients.

With simultaneous use with narcotic analgesics and antipsychotics, orthostatic hypotension may develop.

Antacids reduce the bioavailability of Captopril by 45%, increase the time to reach maximum plasma concentration by 1.5 hours and slow down the development of the antihypertensive effect.

Captopril reduces the hypoglycemic effect of antidiabetic drugs (insulin, sulfonylurea derivatives) and can cause hyperglycemia.

With the use of alpha-blockers, it is possible to increase the antihypertensive effects of Captopril and increase the risk of developing orthostatic hypotension.

With simultaneous use with other antihypertensive drugs, it is possible to increase the hypotensive effect of Captopril.

When used simultaneously with nitroglycerin and other nitrates or vasodilators, caution should be exercised.

The simultaneous use of allopurinol, procainamide, cytostatics or immunosuppressants with ACE inhibitors can lead to an increased risk of leukopenia, especially if the recommended doses are not followed.

The simultaneous use of lithium with ACF inhibitors leads to an increase in the concentration of lithium in the blood serum. The use of captopril with lithium is not recommended, but if necessary, serum lithium levels are closely monitored.

special instructions

In patients with arterial hypertension, when using Captopril, severe arterial hypotension is observed only in rare cases; the likelihood of developing this condition increases with increased loss of fluids and salts (for example, after intensive diuretic treatment), in patients with heart failure, or on dialysis.

In rare cases, with uncomplicated arterial hypertension, signs of hypotension may be observed.

Patients with heart failure have a higher risk of developing arterial hypotension.

Use with extreme caution in patients with autoimmune diseases due to the increased risk of neutropenia and agranulocytosis.

Cough with the appointment of ACF inhibitors is unproductive, persistent, and disappears after discontinuation of therapy.

In rare cases, after long-term treatment with ACF inhibitors, including Captopril, severe Quincke's edema may develop. In this case, immediate withdrawal of the drug and appropriate therapy are required.

During therapy with Captopril, regular monitoring of blood pressure, peripheral blood patterns, protein levels, plasma potassium, urea, creatinine, renal function, body weight, diet is necessary.

Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous machinery.

Caution is required when driving or performing other work requiring increased attention, as dizziness is possible, especially after taking the initial dose of Captopril.

Overdose

Symptoms:acute arterial hypotension, bradycardia, impaired cerebral circulation, thromboembolism, angioedema, disturbances in water and electrolyte balance.

Captopril, Captopril-Norton is produced in the form of tablets containing the active ingredients of Captopril 25 mg or 50 mg,

About the drug

Captopril is an ACE inhibitor. It has hypotensive (reduces pressure), vasodilator, cardioprotective, natriuretic effect. Prevents the transition of angiotensin I to angiotensin II and prevents the inactivation of endogenous vasodilators.

With prolonged use, Captopril reduces the severity of left ventricular myocardial hypertrophy, prevents the progression of heart failure and slows down the development of left ventricular dilatation.

It has a cardioprotective effect (protects the heart) - it dilates the arteries to a greater extent than the veins. Improves blood flow to the ischemic myocardium and reduces platelet aggregation. Captopril helps to reduce sodium content in patients with CHF.

Maximum content active substance in blood plasma is reached after 30-90 minutes. Due to the vasodilator and hypotensive effect, the use of captopril from pressure has become widespread. But not everyone knows in which case it is appropriate to use the drug without harm to health.

How to apply captopril at what pressure? The instructions for use say that the drug has a hypotensive effect, which means Captopril tablets are taken with high blood pressure.

What does captopril help with?

The drug is used for the following pathologies and conditions:

1. Arterial hypertension incl. renovascular (mild or moderate - as the first-line drug of choice; severe - with ineffectiveness or poor tolerance of standard treatment).
2. Heart failure (in complex therapy). Captopril is prescribed for the treatment of CHF with a decrease in ventricular systolic function, as well as in combination with other drugs.
3. LV dysfunction after myocardial infarction in clinically stable condition.
4. Essential hypertension (persistent rise in blood pressure of an unclear cause).
5. Prevention renal failure in patients with diabetic nephropathy or other kidney disease (with or without hypertension).

Instructions for use Captopril, dosages

How to take captopril? The main way to take captopril is by mouth 1 hour before meals. The dosage regimen is set individually.

With essential hypertension ( high blood pressure) start taking captopril tablets with the lowest effective dose of 12.5 mg 2 times a day (rarely 6.25 mg 2 times a day). Attention should be paid to the tolerability of the drug during the first hour.

For the treatment of chronic heart failure (CHF), captopril is prescribed if the use of diuretics does not provide therapeutic effect... The initial dosage is 6.25 mg or 12.5 mg 3 times a day, if necessary, the dose is increased to 25 mg 3 times a day. In the future, additional correction is possible with an interval of at least 2 weeks in the direction of increasing the dose.

The maximum daily dosage of Captopril is 150 mg.

With diabetic nephropathy (insulin-dependent diabetes) - the initial daily dose is 6.25 mg. The increase should be done gradually to the recommended daily dose of 75 mg - 100 mg in three divided doses. With a total protein clearance of more than 500 mg per day, the drug is effective at a dose of 25 mg 3 times a day.
In case of impaired renal function, doses are set taking into account creatinine clearance. The maximum daily dose should not exceed 75-100 mg.

In old age, the dose of Captopril is selected individually, it is recommended to start therapy with a dose of 6.25 mg 2 times / day and, if possible, maintain it at this level.

Currently, due to the short duration of action, the drug is used only to relieve crises by resorption - 25-50 mg captopril under the tongue.

special instructions

Captopril should be used under regular medical supervision. During therapy, monitoring of blood pressure, peripheral blood patterns, protein levels, plasma potassium, urea nitrogen, creatinine, and renal function is necessary.

It is recommended to exclude the use of alcoholic beverages... Use the drug with caution when driving vehicle and people whose professions are associated with high concentration of attention.

Contraindications Captopril

Hypersensitivity to captopril or other ACE inhibitors, pregnancy, lactation (in Russia, the drug is not approved for use in persons under 18 years of age).
The drug is prohibited if:

• development of angioedema;
• severe renal and liver dysfunction;
• cardiogenic shock;
• tendency to arterial hypotension;
• the presence of severe heart defects.

Concomitant use of bone marrow depressants and captopril increases the patient's risk of potentially fatal neutropenia and agranulocytosis.

Side effect of Captopril

• Dizziness, headache, tiredness, asthenia, paresthesia.
• Severe hypotension, tachycardia, peripheral edema; rarely - tachycardia.
• Nausea, decreased appetite, dry mouth, change in taste, nausea, abdominal pain, rarely - hepatitis and jaundice.
• Rarely - neutropenia, anemia, thrombocytopenia; very rarely in patients with autoimmune diseases - agranulocytosis.
• Hyperkalemia, acidosis, hyponatremia.
• Proteinuria, impaired renal function (increased concentration of urea and creatinine in the blood).
• Dry cough.
• Skin rash; rarely - Quincke's edema, bronchospasm, serum sickness, lymphadenopathy; in some cases - the appearance of anti-nuclear antibodies in the blood.

Analogues of Captopril, list

Analogues Captopril and other names of the drug (trade marks), a list of drugs:

• Vero-Captopril
• Kapoten
• Capto
• Captopril
• Captopril Hexal
• Captopril-Akos
• Captopril-Acri
• Captopril-Biosynthesis
• Captopril-MIC
• Captopril-N.S.
• Captopril-STI
• Captopril-Ferein
• Captopril-FPO
• Captopril-Egis

Please note that the instructions for using captopril, the price and reviews are not suitable for analogues. When changing the drug, consult your doctor. Dosage adjustments or other side effects or contraindications may be necessary. This is due to the different concentration of the active substance and auxiliary agents.

FAQ

Kapoten or Captopril, which is better? These are preparations that are identical in active substance. Capoten contains 25 mg. captopril active ingredient. In fact, they are just different brands.

Can I take captopril for high blood pressure? Yes, captopril is used for high and high blood pressure, hypertension. See instructions for use and dosage above.

What is the pressure to take captopril? With increased. Specific figures and dosage should be prescribed by a doctor, taking into account age, possible diseases and other factors. Self-medication is unacceptable. The heart is not a toy!

Captopril and alcohol - you should refrain from drinking alcohol while taking the pills of the drug. For heart problems, it is better to abstain altogether.

How to take captopril under the tongue - take 1 tablet 25-50mg. This way of taking the drug is common during crises. The usual use is inside.

ACE inhibitor

Active substance

Captopril (captopril)

Release form, composition and packaging

10 pieces. - contour cell packaging (1) - cardboard packs.
10 pieces. - contour cell packages (2) - cardboard packs.
10 pieces. - contour cell packages (3) - cardboard packs.
10 pieces. - contoured cell packaging (4) - cardboard packs.
10 pieces. - contour cell packaging (5) - cardboard packs.
10 pieces. - contour cell packaging (10) - cardboard packs.

pharmachologic effect

The mechanism of antihypertensive action is associated with competitive inhibition of ACE activity, which leads to a decrease in the rate of conversion of angiotensin I to angiotensin II and eliminates its vasoconstrictor effect.

As a result of a decrease in the concentration of angiotensin II, a secondary increase in blood renin activity occurs due to the elimination of negative feedback with the release of renin and a direct decrease in the secretion of aldosterone. Due to its vasodilating action, it reduces the total peripheral vascular resistance (afterload), the pressure of wedging in the pulmonary capillaries (preload) and the resistance in the pulmonary vessels; increases cardiac output and exercise tolerance. Does not affect lipid metabolism.

It causes a decrease in the degradation of bradykinin (one of the effects of ACE) and an increase in the synthesis of Pg.

The antihypertensive effect does not depend on the plasma renin activity, a decrease in blood pressure is noted at normal and even reduced hormone concentration, which is due to the effect on tissue RAAS. Strengthens coronary and renal blood flow.

With prolonged use, it reduces the severity of hypertrophy of the myocardium and walls of resistive arteries. Improves blood supply to the ischemic myocardium.

Reduces platelet aggregation.

Pharmacokinetics

Absorption and distribution

After oral administration, at least 75% of the drug is rapidly absorbed and C max is observed in the blood after 50 minutes.

Protein binding, mainly with, is 25-30%.

Metabolism and excretion

Captopril is metabolized in the liver.

T 1/2 is about 3 hours. More than 95% of the drug is excreted in the urine, of which 40-50% is unchanged, the rest is excreted in the form of metabolites. The duration of the drug is about 5 hours.

Indications

- arterial hypertension (including renovascular);

In the event of the development of angioedema, the drug is canceled and careful medical supervision is carried out. If the edema is localized on the face, special treatment is usually not required (antihistamines can be used to reduce the severity of symptoms); in the event that the edema spreads to the tongue, pharynx or larynx and there is a threat of airway obstruction, epinephrine (adrenaline) s / c (0.5 ml at a dilution of 1: 1000) should be administered immediately.

Influence on the ability to drive vehicles and use mechanisms

During the period of treatment with captopril, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions, because dizziness is possible, especially after taking the initial dose.

Pediatric use

Contraindication: age up to 18 years (efficacy and safety have not been established).

With impaired renal function

Patients with impaired renal function: with a moderate degree of renal dysfunction (CC not less than 30 ml / min / 1.73 m 2), captopril can be prescribed at a dose of 75-100 mg / day. With a more pronounced degree of renal dysfunction (CC less than 30 ml / min / 1.73 m 2), the initial dose should be no more than 12.5-25 mg / day; in the future, if necessary, at sufficiently long intervals, the dose of captopril is gradually increased, but a lower than usual daily dose of the drug is used.

For violations of liver function

Contraindication: severe liver dysfunction.

Use in the elderly

FROM caution apply: old age.

Terms of dispensing from pharmacies

The drug is available by prescription.

Storage conditions and periods

List B. Store in a dry place at temperatures below 30 ° C. Keep out of the reach of children. The shelf life is 3 years.

Nowadays, there are many different drugsthat help to cope with certain problems.

For each disease, there are more than 10 different medications that affect the body in completely different ways and help in a particular situation.

Each person is different, and the selection of drugs should be exactly the same. Therefore, any remedy should be taken only after visiting a doctor. In such cases, the dosage and the drug itself will be selected correctly, especially when it comes to tablets that reduce or increase.

It is to such medications that it can be attributed. This medicine has long been used by doctors and is very often prescribed to patients who have difficulties with blood pressure. So what is Captopril for, and how should you take it?

Captopril acts as a stabilizing and lowering blood pressure agent, which by its mechanism is associated with a competitive one.

The drug itself is an inhibitor, which is prescribed to patients with severe and other diseases that arise against the background of unstable blood pressure.

This tool quickly helps to reduce the rate of change in angiotensin 1 and its conversion into the 2nd form. This drug induces a vasoconstrictor effect by stimulating aldosterone in the cortex.

The drug can be taken as a permanent remedy for patients with high blood pressure or cardiac instability. However, the appointment is prescribed only by the doctor after a complete examination of the patient.

Continuous intake of this medication does not allow bradykinin to disintegrate, while it is created, which guarantees excellent resistance in absolutely all vessels of the body.

The drug can help reduce as well as prevent an increase in heart failure and improve blood circulation, reduce platelet aggregation.

The medicine Captopril: what helps?

Captopril has worked well in the fight against, it is widely used to reduce the burden on the heart. Thanks to this, the agent is used in arterial hypertensive therapy, as well as for cardiac weakness and diabetic nephropathy.

Basically, the drug is prescribed to people with such symptoms and diseases:

1. the form ischemic disease heart and unstable work of the left ventricle, but only in cases where the patient has a stable dynamics of the course of the disease;
2. complex treatment for heart failure;
3. cardiomyopathy different types, but at the same time it is necessary to correctly and accurately select the required dosage for each person individually.

In any case, Captopril has been used by many doctors for a long time, because the medicine has passed a lot clinical research and has shown excellent results in the fight against hypertension and heart failure. Thanks to this, we can safely say that the remedy is necessary for most patients with different forms hypertension.

If necessary, tablets are taken for other diseases in combination with other drugs. Such a complex is prescribed only by the attending physician according to the individual indicators of the patient.

Contraindications

Captopril should not be taken, and it is also contraindicated for women during planning, at any gestational age, and when breastfeeding.

Captopril is contraindicated in the following diseases and disorders:

1. diseases and disorders of the liver;
2. renal artery stenosis;
3. the last stage of left ventricular failure;
4. the rehabilitation period after liver transplant;
5. allergy or hypersensitivity to drug components.

With the above diseases and disorders, this drug is strictly prohibited to any person. Taking Captopril tablets must be fully approved by your doctor.

With the wrong method of treatment and non-compliance with the instructions, the medicine can worsen the patient's condition and lower his blood pressure. This will lead to the most difficult diseases and consequences.

Instructions for use

The tablets are taken only after the doctor's appointment and after a complete examination of the patient. It is produced in tablets - 40 pieces of 25 mg each, which must be taken orally. For better effect the pill is put, which increases the absorption of useful elements and substances.

This leads to a rapid decrease in blood pressure and its normalization. In any case, when using Captopril, you must consult your doctor and only then start taking these pills.

Captopril tablets

In order to cure a persistent increase in pressure, the drug is prescribed in an initial dose of 12.5 mg 3 times a day. If the result is poor, then the volume can be increased over time with an interval of 1 to 3 weeks. When the optimal effect is achieved, the dose can be reduced.

With calm current arterial hypertension, a maintenance dose of 37.5 mg per day is usually taken. The maximum intake in such cases may be 50 mg 2 times a day. The maximum dose may be 50 mg 3 times a day.

The maximum dose in 24 hours for any person can be no more than 150 mg.

It is most effective to take the pill on an empty stomach. If there is a need for a quick hypotensive effect, then it is necessary to use the drug in a dose of 25 mg, placing the pill under the tongue.

This will speed up the process of lowering blood pressure several times and quickly improve the patient's well-being. In case of heart weakness, pills are prescribed if they do not cause a positive effect. The minimum dose is 6.25 mg 2 times a day, which can be increased over time for 2 weeks.

The maintenance dose is 25 mg 2-3 times a day. The maximum dose for any patient can be 150 mg per day. For those suffering from heart failure and hypertension, the drug is prescribed on an individual basis. Most often, you need to start taking it with 6.25 mg per day.

It is necessary to increase the intake slowly, reaching a maximum result of 150 mg per day.

With a sufficiently high blood pressure, older people are prescribed additional drugs that are combined with Captopril.

Taking such a joint course can continue long time, it all depends on the progress of the disease and the patient's condition. This drug belongs to, it must be taken in extremely urgent cases.

If the patient's pressure rises above the norm, which was determined by the doctor, then the pill can be taken earlier than written in the instructions, but it is not recommended to take more than the prescribed norm.

Side effects

According to the instructions, this remedy has its own side effects.

First of all, this is face redness and pallor, slight irritation on the hands and other skin areas, insomnia, hair loss, drowsiness, and vomiting.

In rare cases, a dermatological rash, impaired renal function, stomach discomfort, and dry mouth may appear. In very rare cases, there is a change or loss of taste, profuse, visual impairment.

If the medication causes strong negative reactions, then you should stop taking it and consult your doctor as soon as possible.

Due to the fact that the drug can cause dizziness and should be discarded dangerous species occupations and works.

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