Pain 

What is Pentalgin from? Pentalgin - contraindications, from which it helps, analogues

ABON BIOPHARM (Hangzhou) Co., LTD Ai Di Ti Biologica GmbH Moscow Endocrine Plant, FGUP THFZ ICN Pharmstandard, Pharmstandard-Leksredstva LLC Pharmstandard-Tomskhimfarm OJSC

Country of origin

Russia

Product group

Pain medications

Analgesic-antipyretic combined composition

Release forms

  • 10 - contoured cell packs (1) - cardboard packs 12 - contour cell packs (1) - cardboard packs 12 - contour cell packs (1) - cardboard packs. 12 - contour cell packs (1) - cardboard packs. 12 - contoured cell packages (2) - cardboard packs. 4 - contoured cell packages (1) - cardboard packs

Description of the dosage form

  • Tablets of white or white color with a yellowish or creamy shade, flat-cylindrical, with the abbreviated name of the drug "PENT-N" embossed on one side. Tablets, white or white with a cream shade, biconvex, in the form of a capsule with flat lateral surfaces, with a scribble on one side and the inscription "PENTALGIN" on the other, marbling is allowed. Tablets from white to white with a yellow or cream shade, biconvex, in the form of a capsule with flat lateral surfaces, scored on one side and engraved "PENTALGIN" on the other. Film-coated tablets from light green to green, biconvex, in the form of a capsule with beveled edges, scored on one side and embossed "PENTALGIN" on the other; on a cut a tablet of light green with a color with white splashes. Tablets, film-coated from light green to green, biconvex, in the form of a capsule with beveled edges, with a score on one side and embossing "PENTALGIN" - on the other; on a cut a tablet is light green with a color with white blotches.

pharmachologic effect

The combined preparation has an analgesic, anti-inflammatory, antispasmodic, antipyretic effect. Paracetamol - an analgesic-antipyretic, has antipyretic and analgesic effects due to the blockade of COX in the central nervous system and the effect on the centers of pain and thermoregulation. Naproxen is an NSAID that has anti-inflammatory, analgesic and antipyretic effects associated with non-selective suppression of the activity of COX, which regulates the synthesis of prostaglandins. Caffeine is a psychostimulant that causes expansion blood vessels skeletal muscles, heart, kidneys; increases mental and physical performance, helps to eliminate fatigue and drowsiness; increases the permeability of histohematogenous barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect. Has a tonic effect on the vessels of the brain. Drotaverine - has a myotropic spasmolytic effect due to inhibition of PDE 4, acts on smooth muscles Gastrointestinal tract, biliary tract, genitourinary system, vessels. Pheniramine is a histamine H1 receptor blocker. It has an antispasmodic and mild sedative effect, reduces exudation phenomena, and also enhances the analgesic effect of paracetamol and naproxen.

Pharmacokinetics

Metamizole sodium In the intestinal wall, it is hydrolyzed to form an active metabolite, 4-methyl-amino-antipyrine, which in turn is metabolized to 4-formyl-amino-antipyrine and other metabolites. The binding of the active metabolite to proteins is 50-60%. Metabolites are excreted by the kidneys and excreted in breast milk. Naproxen Bioavailability is 95%. Binds to blood proteins. T1 / 2 - 12-15 hours. It is excreted in the urine mainly in the form of a metabolite (dimethylnaproxen), in small quantities in the bile. Caffeine is well absorbed in the intestines. T1 / 2 - 5 hours (sometimes up to 10 hours). It is excreted mainly by the kidneys in the form of metabolites, about 10% - unchanged. Codeine Slightly binds to plasma proteins. Undergoes biotransformation in the liver (10% is converted to morphine by demethylation). It is excreted by the kidneys (5-15% - unchanged). Phenobarbital Bioavailability is 80%. Plasma protein binding - 50%. Penetrates well through the placental barrier. Biotransformed in the liver. The main metabolite has no pharmacological activity. It is excreted by the kidneys, incl. 20-25% - unchanged.

Special conditions

Avoid the simultaneous use of Pentalgin® with other drugs containing paracetamol and / or NSAIDs, as well as with drugs to relieve symptoms of colds, flu and nasal congestion. When using the drug Pentalgin® for more than 5-7 days, the peripheral blood parameters should be monitored and functional state liver. Paracetamol distorts results laboratory research the content of glucose and uric acid in the blood plasma. If it is necessary to determine the 17-ketosteroids, Pentalgin® should be canceled 48 hours before the study. It should be borne in mind that naproxen increases bleeding time. The effect of caffeine on the central nervous system depends on the type nervous system and can be manifested both by excitement and inhibition of the higher nervous activity... During treatment, the patient should avoid drinking alcohol. Influence on the ability to drive vehicles and control mechanisms In some cases, it is possible to reduce the concentration of attention and the speed of psychomotor reactions, therefore, during the period of treatment, the patient should be careful when driving vehicles and engaging in other potentially dangerous species activities requiring increased concentration of attention and speed of psychomotor reactions.

Structure

  • paracetamol 300 mg propiphenazone 250 mg caffeine 50 mg codeine phosphate 8 mg phenobarbit 10 mg Excipients: colloidal silicon dioxide (aerosil), sodium carboxymethyl starch (primogel), povidone (Plasdon K25), microcrystalline cellulose (sodium lauryl sulfate, sodium lauryl sulphate) paracetamol 325 mg naproxen 100 mg caffeine 50 mg drotaverine hydrochloride 40 mg pheniramine maleate 10 mg Excipients: microcrystalline cellulose, potato starch, croscarmellose sodium, hyprolose (hydroxypropyl cellulose (clutcel EF)), citric acid monohydrate 1), butylhydroxyhydrate (1) butyl hydroxide dye quinoline yellow (E104), indigo carmine (E132). The composition of the film shell: hypromellose (hydroxypropyl methylcellulose), povidone (medium molecular weight polyvinylpyrrolidone), polysorbate 80 (tween 80), titanium dioxide, talc, quinoline yellow dye (E104), indigo carmine (E132). paracetamol 325 mg naproxen 100 mg caffeine 50 mg drotaverine hydrochloride 40 mg pheniramine maleate 10 mg Excipients: microcrystalline cellulose, potato starch, croscarmellose sodium, hyprolose (hydroxypropyl cellulose (clutcel EF)), citric acid monohydrate 32 butylhydrolate (chicholate) yellow (E104), indigo carmine (E132). The composition of the film shell: hypromellose (hydroxypropyl methylcellulose), povidone (medium molecular weight polyvinylpyrrolidone), polysorbate 80 (tween 80), titanium dioxide, talc, quinoline yellow dye (E104), indigo carmine (E132).

Pentalgin indications for use

  • - pain syndrome of various origins, including pain in joints, muscles, radiculitis, algomenorrhea, neuralgia, toothache, headache (including due to cerebral vasospasm); - pain syndrome associated with smooth muscle spasm, incl. with chronic cholecystitis, gallstone disease, postcholecystectomy syndrome, renal colic; - post-traumatic and postoperative pain syndrome, incl. accompanied by inflammation; - colds accompanied by a febrile syndrome (as symptomatic therapy).

Pentalgin contraindications

Pentalgin side effects

  • Allergic reactions: skin rash, itching, urticaria, angioedema. From the hematopoietic system: thrombocytopenia, leukopenia, agranulocytosis, anemia, methemoglobinemia. From the side of the central nervous system: agitation, anxiety, increased reflexes, tremors, headache, sleep disturbances, dizziness, decreased concentration. From the side of the cardiovascular system: palpitations, arrhythmias, increased blood pressure. From the side digestive system: erosive and ulcerative lesions of the gastrointestinal tract, nausea, vomiting, epigastric discomfort, abdominal pain, constipation, liver dysfunction. From the urinary system: impaired renal function. From the senses: hearing loss, tinnitus, increased intraocular pressure in patients with angle-closure glaucoma. Others: dermatitis, tachypnea (rapid breathing). If any of the side effects indicated in the instructions are aggravated, or the patient notes any other side effectsnot specified in the instructions, he must inform the doctor about it.

Drug interactions

With the simultaneous administration of the drug Pentalgin® with barbiturates, tricyclic antidepressants, rifampicin, ethanol, the risk of hepatotoxic action increases (these combinations should be avoided). Paracetamol enhances the effect of anticoagulants indirect action and reduces the effectiveness of uricosuric drugs Long-term use of barbiturates reduces the effectiveness of paracetamol. With the simultaneous use of paracetamol with ethanol increases the risk of acute pancreatitis... Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic effects of paracetamol. Diflunisal increases the plasma concentration of paracetamol by 50%, which increases the risk of hepatotoxicity. Naproxen can cause a decrease in the diuretic effect of furosemide, an increase in the effect of indirect anticoagulants, increases the toxicity of sulfonamides and methotrexate, reduces the excretion of lithium and increases its concentration in blood plasma.

Overdose

pallor skin, anorexia (lack of appetite), abdominal pain, nausea, vomiting, gastrointestinal bleeding, agitation, restlessness, confusion, tachycardia, arrhythmia, hyperthermia (fever), frequent urination, headache

Storage conditions

  • store in a dry place
  • keep away from children
  • store in a dark place
Information provided

Spasmodic analgesic

Active ingredients

Caffeine
- (paracetamol)
- drotaverine hydrochloride (drotaverine)
- naproxen (naproxen)
- pheniramine maleate (pheniramine)

Release form, composition and packaging

◊ Film-coated tablets light green to green in color, biconvex, capsule-shaped with beveled edges, scored on one side and "PENTALGIN" embossed on the other; on a cut a tablet is light green with a color with white blotches.

Excipients: microcrystalline cellulose - 128 mg, potato starch - 55.38 mg, croscarmellose sodium - 32 mg, hyprolose (hydroxypropyl cellulose) - 32.52 mg, citric acid monohydrate - 3 mg, butylhydroxytoluene (E321) - 0.3 mg, magnesium, stearate - 7.2 mg talc - 16.12 mg, quinoline yellow dye (E104) - 0.4608 mg, (E132) - 0.0192 mg.

Shell composition: hypromellose (hydroxypropyl methylcellulose) - 12.17 mg, povidone (medium molecular weight polyvinylpyrrolidone, povidone K25) - 3.87 mg, polysorbate 80 (tween 80) - 1.1 mg, titanium dioxide - 3.43 mg, talc - 4.218 mg, quinoline yellow dye 0.2 (E104) - mg, indigo carmine (E132) - 0.0127 mg,
or Shell Opadry 13A210001 Green (OPADRY 13A210001 GREEN) - 25.0007 mg [hypromellose - 12.17 mg, - 3.87 mg, polysorbate 80 - 1.1 mg, titanium dioxide - 3.43 mg, talc - 4.218 mg, quinoline yellow - 0.2 mg, DF&C blue # 2 / indigo carmine - 0.0127 mg].

2 pcs. - contour cell packaging (1) - cardboard packs.
2 pcs. - contour cell packages (2) - cardboard packs.
4 things. - contour cell packaging (1) - cardboard packs.
4 things. - contour cell packages (2) - cardboard packs.
6 pcs. - contour cell packaging (1) - cardboard packs.
6 pcs. - contour cell packages (2) - cardboard packs.
10 pieces. - contour cell packaging (1) - cardboard packs.
10 pieces. - contour cell packages (2) - cardboard packs.
12 pcs. - contour cell packaging (1) - cardboard packs.
12 pcs. - contour cell packages (2) - cardboard packs.

pharmachologic effect

The combined preparation has an analgesic, anti-inflammatory, antispasmodic, antipyretic effect.

Paracetamol - an analgesic-antipyretic, has an antipyretic and analgesic effect due to the blockade of COX in the central nervous system and the effect on the centers of pain and thermoregulation.

Naproxen - NSAIDs, has anti-inflammatory, analgesic and antipyretic effects associated with non-selective suppression of the activity of COX, which regulates the synthesis of prostaglandins.

Caffeine - psychostimulant, causes the expansion of the blood vessels of skeletal muscles, heart, kidneys; increases mental and physical performance, helps to eliminate fatigue and drowsiness; increases the permeability of histohematogenous barriers and increases the bioavailability of non-narcotic, thereby enhancing the therapeutic effect. Has a tonic effect on the vessels of the brain.

Drotaverine - has a myotropic antispasmodic effect due to inhibition of PDE 4, acts on the smooth muscles of the gastrointestinal tract, biliary tract, genitourinary system, blood vessels.

Pheniramine - blocker of histamine H 1 -receptors. It has an antispasmodic and mild sedative effect, reduces exudation phenomena, and also enhances the analgesic effect of paracetamol and naproxen.

Pharmacokinetics

Data on the pharmacokinetics of Pentalgin are not provided.

Indications

  • pain syndrome of various origins, incl. joint pain, muscle pain, sciatica, algodismenorrhea, neuralgia, toothache, headache (including those caused by cerebral vasospasm);
  • pain syndrome associated with spasm of smooth muscles, incl. with chronic cholecystitis, gallstone disease, postcholecystectomy syndrome, renal colic;
  • post-traumatic and postoperative pain syndrome, incl. accompanied by inflammation;
  • colds accompanied by a febrile syndrome (as symptomatic therapy).

Contraindications

  • erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
  • gastrointestinal bleeding;
  • complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance or other NSAIDs (including in history);
  • severe liver failure;
  • severe renal failure;
  • oppression of bone marrow hematopoiesis;
  • condition after coronary artery bypass grafting;
  • severe organic diseases of the cardiovascular system (including acute myocardial infarction);
  • paroxysmal tachycardia;
  • frequent ventricular premature beats;
  • severe arterial hypertension;
  • hyperkalemia;
  • pregnancy;
  • lactation period (breastfeeding);
  • children and adolescents up to 18 years old;
  • hypersensitivity to drug components.

FROM caution the drug should be used in patients with cerebrovascular diseases, diabetes mellitus, diseases peripheral arteries, history of ulcerative lesions of the gastrointestinal tract, with renal and hepatic insufficiency mild or medium severity, viral hepatitis, alcoholic liver damage, benign hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), epilepsy, with a tendency to seizures, glucose-6-phosphate dehydrogenase deficiency, in elderly patients.

In the presence of any of the listed diseases and conditions, the patient should consult a doctor before using the drug.

Dosage

The drug is administered orally, 1 tab. 1-3 times / day The maximum daily dose is 4 tab.

The duration of treatment is no more than 3 days as an antipyretic agent and no more than 5 days as a pain reliever. Continuation of drug treatment is possible only after consulting a doctor.

Do not exceed the indicated dose of the drug.

Side effects

Allergic reactions: skin rash, itching, urticaria, angioedema.

From the hematopoietic system: thrombocytopenia, leukopenia, agranulocytosis, anemia, methemoglobinemia.

From the side of the central nervous system: agitation, anxiety, increased reflexes, tremors, headache, sleep disturbances, dizziness, decreased concentration.

On the part of the cardiovascular system: palpitations, arrhythmias, increased blood pressure.

From the digestive system: erosive and ulcerative lesions of the gastrointestinal tract, nausea, vomiting, epigastric discomfort, abdominal pain, constipation, liver dysfunction.

From the urinary system: impaired renal function.

From the senses: hearing loss, tinnitus, increased intraocular pressure in patients with angle-closure glaucoma.

Others: dermatitis, tachypnea (rapid breathing).

If any of the side effects indicated in the instructions are aggravated, or the patient notes any other side effects not listed in the instructions, he should inform the doctor about it.

Overdose

Symptoms: pallor of the skin, anorexia (lack of appetite), abdominal pain, nausea, vomiting, gastrointestinal bleeding, agitation, restlessness, confusion, tachycardia, arrhythmia, pyrexia (fever), urinary frequency, headache, tremor, or muscle twitching; epileptic seizures, increased activity of hepatic transaminases, hepatonecrosis, increased prothrombin time. Symptoms of liver dysfunction may appear 12-48 hours after an overdose. In severe overdose, hepatic failure develops with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis; arrhythmia, pancreatitis. If you suspect an overdose, you should immediately seek medical help.

Treatment: gastric lavage followed by administration activated carbon... Acetylcysteine \u200b\u200bis a specific antidote for paracetamol poisoning. The introduction of acetylcysteine \u200b\u200bis relevant within 8 hours after taking paracetamol. In case of gastrointestinal bleeding, it is necessary to administer antacids and wash the stomach with ice-cold 0.9% solution; maintenance of ventilation and oxygenation; at epileptic seizures - intravenous administration of diazepam; maintaining the balance of fluids and salts.

Drug interactions

With the simultaneous administration of the drug Pentalgin with barbiturates, tricyclic antidepressants, rifampicin, ethanol, the risk of hepatotoxic action increases (these combinations should be avoided).

Paracetamol enhances the effect of indirect anticoagulants and reduces the effectiveness of uricosuric drugs.

Long-term use of barbiturates reduces the effectiveness of paracetamol.

With the simultaneous use of paracetamol with ethanol, the risk of acute pancreatitis increases.

Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic effects of paracetamol.

With simultaneous use with diflunisal, the plasma concentration of paracetamol increases by 50%, which increases the risk of developing hepatotoxicity.

Naproxen can cause a decrease in the diuretic effect of furosemide, an increase in the effect of indirect anticoagulants, increases the toxicity of sulfonamides and methotrexate, reduces the excretion of lithium and increases its concentration in blood plasma.

With the combined use of caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin), it is possible to increase metabolism and increase the clearance of caffeine; while taking caffeine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - a decrease in the metabolism of caffeine in the liver (slowing down its excretion and increasing its concentration in the blood).

The simultaneous use of caffeinated beverages and other drugs that stimulate the central nervous system can lead to overstimulation of the central nervous system.

With the simultaneous use of drotaverine can weaken the antiparkinsonian effect of levodopa.

With the simultaneous use of pheniramine with tranquilizers, hypnotics, MAO inhibitors, ethanol, it is possible to increase the inhibitory effect on the central nervous system.

special instructions

Avoid the simultaneous use of the drug Pentalgin with other drugs containing paracetamol and / or NSAIDs, as well as with drugs to relieve symptoms of colds, flu and nasal congestion.

When using the drug Pentalgin for more than 5-7 days, it is necessary to monitor the parameters of peripheral blood and the functional state of the liver.

Paracetamol distorts the results of laboratory tests of glucose and uric acid in blood plasma.

If it is necessary to determine 17-ketosteroids, Pentalgin should be canceled 48 hours before the study. It should be borne in mind that naproxen increases bleeding time.

The effect of caffeine on the central nervous system depends on the type of the nervous system and can manifest itself as arousal and inhibition of higher nervous activity.

During the period of treatment, you should not consume alcoholic beverages.

Influence on the ability to drive vehicles and use mechanisms

During the period of treatment, the patient should be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Pregnancy and lactation

The drug is contraindicated for use during pregnancy.

If necessary, use of the drug during lactation should stop breastfeeding.

Childhood use

Storage conditions and periods

Store at a temperature not exceeding 25 ° C. Keep out of the reach of children. Shelf life is 2 years.

In addition to obvious contraindications, there are also conditions in which Pentalgin is dangerous to use. These include:

  • circulatory disorders;
  • a history of ulcerative lesions of the gastrointestinal tract;
  • increased content blood sugar;
  • age after 65 years;
  • epilepsy.

Against the background of prolonged use of Pentalgin, more than 3 days, patients may experience the following side effects:

  • the digestive tract can react to prolonged use of Pentalgin with nausea, stomach pain, vomiting, loss of appetite, exacerbation of chronic diseases;
  • circulatory system reacts with a decrease in the number of leukocytes, platelets, anemia;
  • the nervous system reacts with the occurrence of tremors, dizziness, insomnia, increased blood pressure, headache;
  • the heart can react with arrhythmia, increased blood pressure, tachycardia;
  • the urinary system often reacts with the appearance of problems with the functioning of the kidneys, the appearance of nephritis.

Also, the body of a person who takes Pentalgin for a long time reacts with tinnitus, a decrease in visual acuity is observed. In addition, there may be allergic reaction in the form of a rash, edema, anaphylactic shock.

If such phenomena have arisen, then you can wash the stomach, drink activated charcoal. If, after taking Pentalgin, side effects persist for some time, then you must stop taking it and consult a doctor.

The medicine "Pentalgin", from which it helps in many indications, has 5 active components that determine its action.

The nonsteroidal anti-inflammatory substance Naproxen provides antipyretic, analgesic and anti-inflammatory effects. This is achieved due to the ability of the component to inhibit the reproduction of prostaglandins.

Drotaverine hydrochloride has an antispasmodic effect, normalizes the functioning of smooth muscles of the biliary tract, gastrointestinal, genitourinary and vascular systems.

The presence of paracetamol as an active element in the composition allows the drug to have analgesic and antipyretic effects. It does this by blocking cyclooxygenase, an enzyme that promotes the formation of an inflammatory process, as well as inhibition of pain centers and thermoregulation.

Caffeine tones up blood circulation, dilates the vessels of the brain, heart and other organs. The substance invigorates, eliminates drowsiness. Caffeine shows psychostimulating properties, enhances the action of other active ingredients.

Due to the inclusion in the composition of pheniramine, antispasmodic and sedative properties are slightly manifested, the analgesic effect of naproxen and paracetamol increases.

The drug "Pentalgin", reviews and instructions for use confirm this, can provoke unpleasant effects and disorders in work different systems organism. As a result, the following can be observed side effects:

  • allergies;
  • itching, agitation, nausea, or vomiting;
  • kidney dysfunction, skin rash;
  • heartbeat failure, hearing impairment;
  • hives, headache, constipation;
  • leukopenia, tremor, angioedema;
  • hypertension, anxiety, thrombocytopenia;
  • dizziness, agranulocytosis, arrhythmia;
  • anemia, sleep disturbances, methemoglobinemia.

Spasmodic analgesic.

Pentalgin is a combined medication that has anti-inflammatory, antipyretic, analgesic and antispasmodic effects.

  1. Paracetamol is an antipyretic and analgesic substance, the action of which is due to the inhibition of cyclooxygenase in the central nervous system and a direct effect on the centers of thermoregulation and pain in the hypothalamus.
  2. Naproxen is a non-steroidal anti-inflammatory drug with pronounced antipyretic and analgesic properties.
  3. Pheniramine belongs to the group of H1 blockers -histamine receptors... It is an antispasmodic with a slight sedative effect. Enhances the analgesic properties of naproxen and paracetamol.
  4. Drotaverine has a myotropic spasmolytic effect, which is due to the suppression of the activity of the enzyme phosphodiesterase-4.
  5. Caffeine stimulates the expansion of blood vessels in the heart, kidneys and skeletal muscles, improves physical endurance and mental performance, eliminates drowsiness and fatigue, and increases the bioavailability of non-narcotic pain relievers. Tones up the vessels of the brain.

With the development of a hypersensitivity reaction, a rash on the skin (urticaria) may appear and Quincke's edema may develop.

Possible side effects of Pentalgin:

  • hyperreflexia;
  • shiver;
  • dizziness;
  • headache;
  • insomnia;
  • pain in the abdominal region;
  • noise in ears;
  • decrease in severity auditory perception;
  • rapid breathing;
  • oppression of hematopoiesis (manifested by anemia, thrombocytopenia and leukopenia);
  • arterial hypertension (increased pressure);
  • heart rhythm disturbances;
  • palpitations;
  • tachycardia;
  • psycho-emotional excitement;
  • unmotivated feeling of anxiety;
  • impaired ability to concentrate;
  • dyspeptic disorders;
  • lesions of the mucous membranes of the digestive system (erosion and ulcers);
  • decreased functional activity of the liver and (or) kidneys;
  • skin inflammatory reactions (dermatitis).

If at least one of the listed symptoms develops, treatment with the drug should be discontinued and the doctor should be informed of the side effects.

Release forms

Sold in cell packs, 2-12 tablets per pack.

Producing countries:

  • Belmedpreparaty (Belarus);
  • Tomskkhimfarm (Russia).

International name: Pentalgin.

Dosage form - tablets, film-coated: capsule-shaped, biconvex, from light green to green, with beveled edges, on one side - risk, on the other - embossed "PENTALGIN"; a tablet on a cut of light green color with white blotches (2, 6, 10 or 12 tablets in a blister strip, in a cardboard box 1 or 2 packs).

Active substances as part of 1 tablet:

  • Paracetamol - 325 mg;
  • Pheniramine maleate - 10 mg;
  • Naproxen 100 mg
  • Drotaverine hydrochloride - 40 mg;
  • Caffeine 50 mg

Additional substances: hyprolose (hydroxypropyl cellulose) (clotsel EF), magnesium stearate, croscarmellose sodium, potato starch, microcrystalline cellulose, talc, butyl hydroxytoluene (E321), citric acid monohydrate, indigo carmine (E132), yellow dye quin

The composition of the film shell: polysorbate 80 (tween 80), povidone (medium molecular weight medical polyvinylpyrrolidone), talc, titanium dioxide, hypromellose (hydroxypropyl methylcellulose), indigo carmine (E132), quinoline yellow dye (E104).

Analogs of Pentalgin, price in pharmacies

Pentalgin tablets are available in pharmacies without a doctor's prescription. The shelf life of the drug is 3 years from the date of production, after this period the drug is not recommended to be used.

It must be stored in a dry place out of the reach of children at a temperature not exceeding 25 degrees, avoiding direct sunlight on the blister.

If necessary, you can replace Pentalgin with an analogue according to curative action - these are drugs:

  1. Sedalgin;
  2. Pentalffen;
  3. Pentyalgin;
  4. Plivalgin.

By ATX code:

  • Gevadal,
  • Kaffetin,
  • Migraine,
  • No-shpalgin.

When choosing analogues, it is important to understand that the instructions for the use of Pentalgin, the price and reviews for drugs of a similar action do not apply. It is important to consult a doctor and not make your own replacement of the drug.

Store at a temperature not exceeding 25 ° C, in a dry, dark place and out of reach of children. Shelf life is 2 years. Terms of dispensing from pharmacies - without a prescription.

Dispensed without a doctor's prescription.

Dosage and method of administration

Take one tablet after meals. You can take no more than 4 pieces per day medicinal product.

The tablets are taken orally after meals with clean water.

The standard dosage of Pentalgin according to the instructions for use is 1 tablet one time up to 3 times a day. The interval between pills is at least 6 hours.

The maximum daily dosage is 4 tablets.

The drug can be used as an antipyretic for 3 days, anesthetic - 5 days. More long-term use requires medical advice.

special instructions

Pentalgin should not be prescribed with other paracetamol-based products or containing NSAIDs, products to relieve symptoms of colds, flu and nasal congestion.

If the patient takes the drug for more than 7 days, it is necessary to monitor the parameters of peripheral blood and liver function.

The influence of caffeine in the composition of the drug can have both an exciting and inhibitory effect on the central nervous system.

Side effects

The instruction warns of the possibility of developing the following side effects when prescribing Pentalgin:

  • By organs digestive tract - lesions of the gastrointestinal mucosa, exacerbation of chronic diseases of the alimentary canal, nausea, pain in the stomach, sometimes vomiting, stool disorders, liver damage, lack of appetite;
  • From the side of the blood system - a decrease in the level of platelets and leukocytes in the blood, anemia, agranulocytosis;
  • From the side of the central nervous system - tremors of the extremities, headaches, dizziness, insomnia, lethargy, decreased concentration;
  • From the side of the heart and blood vessels - tachycardia, cardiac arrhythmia, increased blood pressure;
  • From the urinary system - the development of interstitial nephritis, impaired renal function;
  • Tinnitus, glaucoma, decreased visual acuity in rare cases;
  • Allergic reactions - skin rash, development of angioedema, urticaria, in rare cases anaphylactic shock.

Contraindications

It is contraindicated to prescribe Pentalgin in the following cases:

  • erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
  • complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses, intolerance to acetylsalicylic acid or other NSAIDs (including in history);
  • severe liver failure;
  • severe renal failure;
  • condition after coronary artery bypass grafting;
  • severe organic diseases of the cardiovascular system (including acute myocardial infarction);
  • paroxysmal tachycardia;
  • hyperkalemia;
  • pregnancy and lactation (breastfeeding);
  • age up to 18 years;
  • hypersensitivity to drug components.

The drug should be used with caution in patients with cerebrovascular diseases, diabetes mellitus, diseases of the peripheral arteries, history of gastrointestinal ulcers, with mild or moderate renal and hepatic insufficiency, viral hepatitis, alcoholic liver damage, benign hyperbilirubinemia (Gilbert's, Dubin's syndromes) Johnson and Rotor), epilepsy, with a tendency to seizures, glucose-6-phosphate dehydrogenase deficiency, and elderly patients.

Overdose

Overdose symptoms are pallor of the skin, anorexia (lack of appetite), abdominal pain, nausea, vomiting, gastrointestinal bleeding, agitation, restlessness, confusion, tachycardia, arrhythmia, hyperthermia (increased body temperature), frequent urination, headache pain, tremors, or muscle twitching.

Possible epileptic seizures, increased activity of hepatic transaminases, hepatonecrosis, increased prothrombin time.

Symptoms of liver dysfunction may appear 12-48 hours after an overdose.

In severe overdose, liver failure develops with progressive encephalopathy, coma, and death. Acute renal failure with tubular necrosis, arrhythmia, pancreatitis.

If you suspect an overdose, you should immediately seek medical help.

The introduction of acetylcysteine \u200b\u200bis relevant within 8 hours after taking paracetamol. In case of gastrointestinal bleeding, it is necessary to administer antacids and wash the stomach with ice-cold 0.9% sodium chloride solution.

Maintaining ventilation and oxygenation. In case of epileptic seizures, intravenous administration of diazepam, maintenance of fluid and salt balance.

The instructions for use indicate that Pentalgin is prescribed orally by 1 tab. 1-3 times / day The maximum daily dose is 4 tab.

The duration of treatment is no more than 3 days as an antipyretic agent and no more than 5 days as a pain reliever. Continuation of drug treatment is possible only after consulting a doctor.

Do not exceed the indicated dose of the drug.

In cases of using tablets long time in high doses, an overdose may occur, which is accompanied by symptoms: pallor of the skin, anorexia, abdominal pain, nausea, vomiting, gastrointestinal bleeding, agitation, anxiety, confusion, tachycardia, arrhythmia, hyperthermia, increased urination, headaches, tremors, epilepticus etc.

More severe forms of overdose are: the development of liver failure with increasing encephalopathy, arrhythmia, pancreatitis, coma, fatal outcome.

Usually treatment includes: gastric lavage, intake of activated charcoal, administration of a specific antidote - acetylcysteine \u200b\u200bor other drugs, depending on the symptomatology.

Contraindications and side effects

Pentalgin for cough

Suitable for the treatment of cough, but only as an adjuvant. 2-3 tablets should be taken daily after meals. It is forbidden to use the drug for more than 3 days. Before use, you should consult your doctor.

Pentalgin for migraine

Pentalgin will help with migraines, but this drug is too strong. For headaches, it is better to use No-Shpu or Tamipul. It is advisable to consult a neurologist. It should also be understood that not everyone, according to various reasons, this drug may work.

Pentalgin for toothache

The duration of the course depends on the complexity of the situation. It is advisable not to consume more than 1 tablet per day. The treatment period is 3 days. Should only be used as directed by a dentist.

Pentalgin and alcohol

Drinking alcohol is strictly prohibited. The effect of the phenobarbital substance is enhanced, which can cause nervous disorders, coma of the brain (extremely rare). Also, the combination of alcohol and 5 active substances at once (codeine, caffeine, naproxen, metamizole sodium and phenobarbital) negatively affects the liver and kidneys.

Pentalgin during pregnancy

The use of Pentalgin is prohibited during pregnancy. You can not use the drug and breastfeeding. Active substance codeine can enter the fetus, which will cause various defects and complications. Addiction to the drug is also possible.

Pentalgin during menstruation

With painful periods, Pentalgin can be used. Most women and girls are advised to take this drug in critical days... However, if the pain is not very severe, it is better to take No-Shpu or any other pain reliever, since Pentalgin is a fairly strong drug. This drug should only be used as a last resort.

The instruction for use prohibits taking the medicine "Pentalgin" when:

  • individual rejection of the constituent components;
  • severe kidney failure;
  • hyperkalemia;
  • ventricular premature beats;
  • high pressure;
  • ulcers and erosions of the stomach and intestines;
  • aspirin asthma or triad;
  • polyps of the paranasal sinuses;
  • paroxysmal tachycardia;
  • myocardial infarction and other complex diseases of the heart and blood vessels;
  • after performed coronary artery bypass grafting;
  • internal bleeding;
  • inhibition of bone marrow hematopoiesis.

You should not use the medicine "Pentalgin" during pregnancy, children under adulthood, during lactation. Care should be taken during therapy for the elderly, as well as those suffering from diabetes, kidney and liver failure on initial stages, pathologies of arteries, convulsions, hepatitis, stomach ulcers in the past.

What does Pentalgin help from? According to the instructions, the drug is prescribed in the following cases:

  • pain syndrome of various origins, incl. joint pain, muscle pain, sciatica, algodismenorrhea, neuralgia, toothache, headache (including those caused by cerebral vasospasm);
  • pain syndrome associated with spasm of smooth muscles, incl. with chronic cholecystitis, gallstone disease, postcholecystectomy syndrome, renal colic;
  • post-traumatic and postoperative pain syndrome, incl. accompanied by inflammation;
  • colds accompanied by a febrile syndrome (as symptomatic therapy).

What does it help from? The use of Pentalgin is indicated for relieving pain:

  1. Caused by spasm of smooth muscles (according to the instructions, the drug is effective, including for renal colic, gallstone disease, chronic cholecystitis, dysfunction of the sphincter of Oddi and a number of other diseases).
  2. Toothache, headache (including pain associated with vasospasm in the brain), muscle or joint pain, as well as pain associated with algodismenorrhea, neuralgia, etc.
  3. Arising against the background of injuries and surgical operations (including when pain is accompanied by the development of an inflammatory process).

In addition, Pentalgin can be used for colds, which are accompanied by a febrile syndrome (used as a symptomatic antipyretic and analgesic).

Contraindications include:

  • severe renal failure;
  • gastrointestinal bleeding;
  • severe arterial hypertension;
  • oppression of bone marrow hematopoiesis;
  • hyperkalemia;
  • frequent ventricular premature beats;
  • individual intolerance to the components of the drug;
  • erosive and ulcerative lesions of the digestive system in the acute stage;
  • condition after the implementation of coronary artery bypass grafting;
  • severe organic diseases of the cardiovascular system (for example, myocardial infarction);
  • a combination of recurrent polyposis of the paranasal sinuses, nose, as well as bronchial asthma against a background of hypersensitivity to acetylsalicylic acid or others non-steroidal drugs;
  • paroxysmal tachycardia;
  • age up to 18 years.

It is not recommended to take Pentalgin during pregnancy, as well as during breastfeeding. With extreme caution, a medication is prescribed in old age and in conditions such as: peripheral artery disease, cerebrovascular ailments, alcoholic liver damage, epilepsy, hepatic and renal failure early stages, diabetes, deficiency of glucose-6-phosphate dehydrogenase, tendency to seizures, viral hepatitis, a history of ulcerative lesions of the digestive system and benign hyperbilirubinemia.

How does Pentalgin work?

Pentalgin consists of 5 active substances, which determine its effectiveness:

  1. Naproxen. A substance of the propionic acid type. It has antipyretic and analgesic properties. It is used in the treatment of arthritis and other rheumatic ailments, diseases of the musculoskeletal system, as well as dysmenorrhea and severe gout.
  2. Drotaverine hydrochloride. Myotropic antispasmodic. In terms of chemical structure and pharmacological properties, it is similar to papaverine, but has a stronger and longer-lasting effect.
  3. Paracetamol. It is a widespread central non-narcotic analgesic that has rather weak anti-inflammatory properties. Antipyretic and analgesic action.
  4. Caffeine. It is a psychostimulant. Caffeine can be found in plants like coffee tree, cocoa, mate, guarana, cola. Normalizes blood circulation, raises tone.
  5. Pheniramine maleate. Penetrating into the body, the substance goes along with the blood flow. Its highest concentration is recorded one hour after consumption. It soothes and has an analgesic effect.

Use during pregnancy and lactation

The drug is contraindicated for use in pregnant women. The active ingredients included in the tablet can adversely affect the bookmark internal organs fetus and cause developmental abnormalities.

Since the components of the drug Pentalgin can be excreted in breast milk, the use of this drug for nursing mothers is contraindicated. If treatment is necessary, a woman should stop breastfeeding and temporarily transfer him to an adapted milk formula.

Pentalgin's analogs

Structure

The combined action of Pentalgin is due to the properties of five active substances. The composition of Pentalgin tablets depends on the type of drug. The manufacturer produces a drug with four names: this allows you to choose the appropriate drug for the individual sensitivity of a person to analgesics. The composition of Pentalgin of all four varieties necessarily includes paracetamol.

He begins to relieve pain, acting on the centers of thermoregulation and pain, relieves spasm. Together with the pain reliever, it has an anti-inflammatory, antipyretic effect. In combination with paracetamol, the manufacturer uses other active substances. The composition of Pentalgin additionally includes four substances, the names of which are indicated in the instructions. The active elements of the drug, together with paracetamol, can be:

  1. Naproxen. This non-steroidal substance regulates the synthesis of prostaglandins, which are responsible for muscle contraction. It relieves spasm, inflammation, lowers the temperature.
  2. Caffeine. It has the ability to dilate blood vessels, increases brain activity, relieves signs of fatigue, drowsiness, and enhances the effect of other pain relievers.
  3. Drotaverine hydrochloride. Relieves spasm of smooth muscles of the genitourinary system, gastrointestinal tract, biliary tract, blood vessels.
  4. Pheniramine maleate. It blocks the synthesis of histamine, has a sedative effect, and fights inflammatory processes. The substance relieves spasm, increases the effect of paracetamol and naproxen.
  5. Propyphenazone.
  6. Codeine. It is a narcotic element. Acts on opioid receptors and alters pain perception. Reduces the degree of arousal of the center responsible for coughing, enhances the effect of anti-inflammatory, sedative substances. Long-term use can cause drug dependence.
  7. Phenobarbital. Refers to barbiturates, increases the analgesic effect of paracetamol and metamizole.
  8. Metamizole sodium. Non-steroidal drug, has an analgesic effect.

Dosage

How to take Pentalgin? The instruction contains the maximum norms for taking the drug. The dosage of Pentalgin is one tablet half an hour before or after a meal with a large amount of water, daily rate - three tablets, in special cases four. It is necessary to observe an interval of four hours between doses of the medicine.

Side effects

Contraindications

It is not recommended to use tablets while taking other medicines, because in combination with other active substances, the toxicity of the drug may increase or the effect of the drug may decrease. It is forbidden to use Pentalgin and alcohol, you cannot take pills while driving, because they reduce attention. It is necessary to carefully take Pentalgin for older people with viral hepatitis, alcoholic liver damage, with epilepsy.

special instructions

Before you start using the drug, read special instructions:

  1. During the period of treatment, you should not consume alcoholic beverages.
  2. Paracetamol distorts the results of laboratory tests of glucose and uric acid in blood plasma.
  3. When using the drug Pentalgin for more than 5-7 days, it is necessary to monitor the parameters of peripheral blood and the functional state of the liver.
  4. The effect of caffeine on the central nervous system depends on the type of the nervous system and can manifest itself as arousal and inhibition of higher nervous activity.
  5. If it is necessary to determine 17-ketosteroids, Pentalgin should be canceled 48 hours before the study. It should be borne in mind that naproxen increases bleeding time.
  6. Avoid the simultaneous use of the drug Pentalgin with other drugs containing paracetamol and / or NSAIDs, as well as with drugs to relieve symptoms of colds, flu and nasal congestion.

During the period of treatment, the patient should be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Interaction with other medicinal products

To avoid a deterioration in the patient's well-being, the interaction of Pentalgin and other medications should be taken into account. So, for example, it is forbidden to drink it together with:


This drug contains substances that can reduce healing effect from medications that are used to treat diabetes. This must be taken into account even during periodic administration of the drug. As a result, during the correction of the condition with Pentalgin, it is important to simultaneously take into account the blood sugar level.

To date, pharmacies offer a variety of drugs that have a pronounced antispasmodic, antipyretic, analgesic effect. Nevertheless, Pentalgin retains an undeniable leadership. This is due to the fact that its combined composition makes it possible to solve many problems with the help of 1 tablet.

Pharmacies as analogues can offer:

  1. Plivalgin.
  2. Sedalgin.
  3. Pentyalgin.
  4. Pentalffen.

The replacement of Pentalgin should be entrusted to the attending physician, since some analogs have serious contraindications that can cause a deterioration in the patient's well-being.

Pentalgin, due to its composition, allows you to solve many problems. It is especially effective for headaches of various etiology and intensity. However, uncontrolled intake of the drug can cause a lot of negative consequences. In order not to develop side effects, it is imperative to follow the instructions and recommendations of the doctor.

The drug is not recommended to be administered simultaneously with barbiturates, Rifampicin, tricyclic antidepressants, drugs that contain ethanol, since such drug interactions increase the risk of toxic liver damage.

You should not prescribe the drug with other drugs that include Paracetamol, as this can lead to the development of serious side effects and hepatotoxicity.

Pentalgin should not be taken simultaneously with Nurofen or other drugs from the group of non-steroidal anti-inflammatory drugs, as the risk of bleeding increases.

Drug interactions with acetylsalicylic acid leads to the formation of ulcers and erosions on the mucous membranes of the gastrointestinal tract, and also increases the risk of bleeding.

Pentalgin cannot be combined with alcoholic beverages and drugs that include ethanol, since in this case there is a high risk of developing acute pancreatitis and severe toxic liver damage.

Naproxen, which is part of the drug, reduces therapeutic action diuretics and enhances the effect of indirect anticoagulants, which should be taken into account and, in order to avoid the development of side effects, do not prescribe these drugs to the patient at the same time.

With the simultaneous use of drugs that contain caffeine, an excessive stimulating effect on the central nervous system is possible, as a result of which the patient will be restless, nervous, and suffer from insomnia.

When using the drug, it is necessary to take into account the interaction with other drugs:

  1. Long-term use of barbiturates reduces the effectiveness of paracetamol.
  2. With the simultaneous use of paracetamol with ethanol, the risk of acute pancreatitis increases.
  3. Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic effects of paracetamol.
  4. Paracetamol enhances the effect of indirect anticoagulants and reduces the effectiveness of uricosuric drugs.
  5. The simultaneous use of caffeinated beverages and other drugs that stimulate the central nervous system can lead to overstimulation of the central nervous system.
  6. With the simultaneous use of drotaverine can weaken the antiparkinsonian effect of levodopa.
  7. With the simultaneous administration of the drug Pentalgin with barbiturates, tricyclic antidepressants, rifampicin, ethanol, the risk of hepatotoxic action increases (these combinations should be avoided).
  8. Naproxen can cause a decrease in the diuretic effect of furosemide, an increase in the effect of indirect anticoagulants, increases the toxicity of sulfonamides and methotrexate, reduces the excretion of lithium and increases its concentration in blood plasma.
  9. With simultaneous use with diflunisal, the plasma concentration of paracetamol increases by 50%, which increases the risk of developing hepatotoxicity.
  10. With the simultaneous use of pheniramine with tranquilizers, hypnotics, MAO inhibitors, ethanol, it is possible to increase the inhibitory effect on the central nervous system.
  11. With the combined use of caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin), it is possible to increase metabolism and increase the clearance of caffeine; while taking caffeine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - a decrease in the metabolism of caffeine in the liver (slowing down its excretion and increasing its concentration in the blood).

Pentalgin is combined drug, which has an effective anti-inflammatory and analgesic effect. The therapeutic effect of the drug is due to the five main active components that make up its composition. Instructions for use of Pentalgin tablets describe it in detail pharmacological properties and effects on the body. According to her, the drug has the ability to inhibit the synthesis of prostaglandins by blocking an enzyme such as cyclooxygenase in the central nervous system.

Pentalgin is a highly effective remedy for severe pain of various etiological nature. This non-steroidal and non-narcotic drug is able to cope with severe pain syndrome, as well as to have a high anti-inflammatory and antipyretic effect. That is, this drug very quickly eliminates pain, various spasms, lowers the temperature and eliminates the focus of inflammation.

The drug has analgesic, antispasmodic, psychostimulating properties and effectively blocks H1-histamine receptors. The action of the drug is provided by the following medicinal substances included in the composition:

  1. Drotaverinum.

Effectively eliminates spasms of any nature, has a beneficial effect on smooth muscles, biliary tract, urinary and vascular system... The substance has a pronounced antispasmodic myotropic effect.

  1. Paracetamol.

It is a non-narcotic analgesic that effectively reduces high temperature and relieves pain. Its analgesic and antipyretic effect is due to the blockade of certain enzymes of the central nervous system, which leads to an effective effect on pain centers and regulates body temperature.

Anti-inflammatory non-steroidal component that quickly eliminates inflammatory process, has a pain relieving effect and can also reduce fever. The action of the substance is associated with the suppression of the enzyme cyclooxygenase, which regulates the synthesis of prostaglandins. Naproxen actively prevents the development of inflammation and pain.

  1. Caffeine.

It expands the blood vessels of tissues and muscles, has a beneficial effect on the kidneys and heart, eliminates fatigue, drowsiness, increases physical and mental performance. Caffeine enhances the bioavailability and effect of analgesics that are included in Pentalgin. It increases the permeability of barriers and increases the therapeutic effect of the drug. Caffeine has a tonic effect on the blood vessels of the brain.

  1. Pheniramine.

It is a blocker of histamine receptors. Effectively relieves spasms and pain of different nature, enhances the analgesic effect of paracetamol and naproxen.

Indications

What does Pentalgin help from? The tool has a very wide range application. The drug is effective for headaches, for rheumatic pains, for pain after surgery. The main indications for the use of the drug:

Also, these drugs are often prescribed:

  • at complex therapy SARS and influenza;
  • at high temperatures;
  • with an inflammatory process;
  • with muscle pain;
  • fever;
  • pain after injury;
  • pain after surgery;
  • pain with gallstone disease;
  • with chronic cholecystitis;
  • renal colic.

The drug is a tablet. The maximum allowable dose of the drug is 4 tablets per day. It is important to know that long-term use of Pentalgin tablets can cause drug dependence. It is not recommended to use the drug in treatment for more than seven days. In case of such a need, it is required to monitor the functioning of the liver and kidneys, as well as the composition of the blood.

Contraindications

Pentalgin should not be used while carrying a baby and while breastfeeding. Also, the drug is not used in the treatment of children under 12 years of age. Main contraindications:

  • tachycardia;
  • myocardial infarction;
  • renal failure;
  • violations in the liver;
  • polyposis of the nose;
  • bronchial asthma;
  • intestinal bleeding;
  • individual intolerance.

Care should be taken to take Pentalgin for elderly people with epilepsy.

Varieties of the drug

The drug Pentalgin N includes sodium metamizole, phenobarbital, codeine, naproxen and caffeine. The medicine is available in tablets, in a blister contour packaging (10 pieces). Phenobarbital provides a sedative effect, calms the nervous system. Codeine blocks certain receptors and effectively relieves pain. The drug is a non-narcotic analgesic. Has a pain relieving effect and effectively copes with painful sensations for various diseases.

Pentalgin N is used to eliminate any pain and in case of febrile conditions. It is used after operations, for colds, neuralgia, myalgia, radiculitis and other diseases. The drug is very effective in relieving toothache, muscle pain and quickly eliminating migraines.

The medication is contraindicated for:


There is also such a medicinal variety as a drug Pentalgin icn... In its composition, this drug contains paracetamol, caffeine, phenobarbital, codeine phosphate, sodium metamizole. It is a combined medication that has anti-inflammatory, analgesic and antipyretic effects. The drug effectively blocks pain by acting on the centers of inflammation. Reduces the peristalsis of the intestinal sphincters, relaxes smooth muscles, eliminates spasms.

The medicine is indicated to eliminate pain syndrome of any etiology, is used for headaches, colds, rheumatism, after surgery. Also, the remedy perfectly eliminates toothache and muscle pain. The drug cannot be used for a long time and uncontrollably.

Contraindications:

Side effect

The drug is very well tolerated by the body and rarely causes side effects. When taking the drug, in rare cases, manifestations such as:

  • nausea;
  • vomiting;
  • stomach ache;
  • sleep disturbance;
  • anemia;
  • visual impairment;
  • heart rhythm failure;
  • noise in the ears;
  • increased intracranial pressure;
  • stool disorders;
  • allergic reaction.

  1. You can not use Pentalgin together with other non-narcotic analgesics, with Aminophenazone, since the joint administration of these drugs causes increased toxicity in the body. Paracetamol, which is part of the drug, enhances the effect of anticoagulants and reduces the effect of enzyme agents.
  2. It is forbidden to treat Pentalgin during alcohol intoxication, since the codeine included in the drug increases the oppressive effect of alcohol on the central nervous system.
  3. Pentalgin enhances the effect of drugs such as Griseofulvin, Phenothiazine, Doxycycline, as well as estrogens and antidepressants. Exposure to tranquilizers and sedatives enhances the analgesic effect of Pentalgin.
  4. The use of the drug in high doses and its long-term use causes drug dependence. The drug must be taken one tablet 1-3 times a day. The tablet is swallowed whole and washed down with a sufficient amount drinking water... Many patients are interested in how long does Pentalgin work? All active components of the drug are quickly absorbed into the stomach tissue and enter the bloodstream, after which they begin their effect in the body. The therapeutic and analgesic effects can be felt within 10-15 minutes after taking one tablet of the drug.
  5. Taking the drug does not depend on food intake. The maximum dose (single) may be, in special cases, two tablets. The duration of treatment is usually prescribed for a period of 5-7 days. In case of urgent need, taking the drug can be continued under the supervision of the attending physician and regular monitoring of blood counts. Pentalgin cannot be used in the treatment of children under 12 years of age.

In case of drug overdose, vomiting, nausea, weakness, decreased heart rate and blood pressure... Also, in case of an overdose, an allergic reaction manifests itself, suppression of the central nervous system.

Bearing a fetus requires a pregnant woman to pay special attention to her health. Any intake of medications can cause the risk of developing various pathologies and developmental disabilities in the unborn child. A pregnant woman needs to be as careful as possible when treating with medications. Any desire to take medications should be coordinated with a gynecologist who knows the peculiarities of the course of pregnancy.

The drug Pentalgin and its varieties Pentalgin N, Pentalgin icn cannot be used during pregnancy! The instruction for the drug from the manufacturers of the drug prohibits its use during the period of bearing a child at any stage of pregnancy. It is better for the expectant mother to use other, less dangerous drugs for pain relief and treatment. Today, the pharmaceutical market offers pregnant women a large selection of various safe homeopathic remedies, which are allowed to use when bearing a fetus.

Also, Pentalgin is not used during the period of feeding the child.The active substances that are part of the drug are very quickly absorbed into the blood and penetrate into breast milk... For treatment with Pentalgin, it is better to transfer the child to artificial feeding or refuse to take this medication.

Taking the drug is allowed after 12 years. Before the indicated age, Pentalgin cannot be used in the treatment of children according to the manufacturer's instructions. medication... For children over 12 years old, it is undesirable to use a single dose in the form of an acceptable two tablets. Otherwise, the drug will have an extremely negative effect on children's organism... You should also limit treatment to two to three tablets per day. The instruction allows children to be given 1 tablet of Pentalgin three times a day.

With the appearance of weakness, nausea, allergies, vomiting, dizziness, tinnitus and other negative side effects taking the drug must be stopped and a doctor must be consulted.

After operation

The drug is a very strong pain reliever, so it is often used to relieve various pains after surgery. Also, the drug can be effectively used after tooth extraction. It is undesirable to take two tablets at a time. The components of the drug are focused on fast action, so you should wait for the pain to subside.

This drug is widely used in the recovery period after severe operations. You should know that a prescription for Pentalgin without codeine is not required to purchase the drug in a pharmacy. If the type of drug does not include codeine in its composition, the drug can be freely purchased at pharmacies.

High efficiency of Pentalgin in eliminating pain after surgical intervention due to the active properties of the components of the drug. In the body, paracetamol binds to plasma proteins and steadily blocks the development of prostaglandins. Medicinal substances the drug acts directly on the receptors that cause pain.

Phenobarbital, which is part of the product, has a relaxing effect on the nervous system, calms down the nerve receptors and reduces excitability. The complex effect of all components of Pentalgin allows you to quickly and persistently eliminate piercing, cutting, pulling pains after surgery.

Analogs

The pharmaceutical market today offers a wide variety of pain relievers. Pentalgin has its advantages over other anesthetic drugs, but sometimes it becomes necessary to replace it with similar drugs. There are cheaper analogs of Pentalgin that have a similar composition and effect. When choosing a drug from a group of analogs, it is important to consult with your doctor in advance. Perhaps due to the characteristics of the body similar drug will not work.

The main analogues of Pentalgin:


In a retail network of pharmacies, the price of a drug may vary. Approximate cost:

  • Pentalgin (12 pcs.) - 85-104 rubles;
  • Pentalgin (24 pcs.) - 160-170 rubles;
  • Pentalgin icn (12 pcs.) - 50 rubles;
  • Pentalgin N with drotaverine - 56-106 rubles;
  • Pentalgin N - 170 rubles.

Average price of peers:

  • Pentyalgin - 130 rubles;
  • Pentalfen - 70 - 100 rubles;
  • Sedal M - 120 - 230 rubles;
  • Plivalgin - 50 rubles;
  • Sedalgin plus - 126 - 260 rubles.
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