Gastal during poisoning. What Gastal tablets help from - instructions for use

Generalcharacteristic

Tablets white or nearly white, round shape with a flat and smooth surface and beveled edges.

Composition of the medicinal product

1 tablet contains active substance: 450 mg of aluminum hydroxide - magnesium carbonate gel and 300 mg of magnesium hydroxide (95.26 mg A13 + and 141.11 mg Mg2 +) and excipients: mannitol, sorbitol, lactose, corn starch, sodium cyclamate, saccharin - sodium, talc, magnesium stearate, mint flavor.

Release form

Pills

Pharmacotherapeuticth group: Means for the treatment of conditions associated with acidity disorders. Antacids. CodeATX: A02AD01.

Pharmacological properties

Pharmacodynamics

The drug neutralizes free hydrochloric acid, which leads to a decrease in the peptic activity of gastric juice.

Aluminum hydroxide, helping to slow down intestinal motility, balances the laxative effect of magnesium hydroxide.

Pharmacokinetics

Orally taken aluminum hydroxide and magnesium hydroxide react with hydrochloric acid in the stomach to form salts, which are only partially absorbed.

The excretion of absorbed salts occurs mainly in the urine.

Preclinical safety data

Data from animal studies did not reveal any danger to humans based on traditional studies of pharmacology, safety, repeated dose toxicity, genotoxicity, carcinogenicity and reproductive toxicity.

Indications for use

Antacid therapy for heartburn and gastroesophageal reflux in patients over 15 years old.

Contraindications

Hypersensitivity to the components of the drug Severe renal failure (since the drug contains magnesium) Age up to 15 years Porphyria Cachexia.

special instructions

A 2-hour interval should be observed between the use of Gastal and other drugs.

The patient should consult a doctor for advice in the event of:

Decrease in body weight; difficulty swallowing and prolonged abdominal discomfort; digestive disorders, which appeared for the first time, changes in existing digestive disorders; renal failure.

Gastal contains mannitol and lactose. The drug is contraindicated in case of fructose intolerance, glucose or galactose malabsorption syndrome, or sucrase-isomaltase deficiency, and should be used with caution in patients with diabetes mellitus due to the presence of sorbitol and sucrose in the composition.

Precautionary measures

The duration of treatment without consulting a doctor should not exceed 10 days. If symptoms persist after 10 days of treatment, or if the condition worsens, the cause should be established and treatment reviewed.

Aluminum hydroxide can cause constipation, an overdose of magnesium salts can lead to intestinal hypokinesia; taking high doses of the drug can cause or worsen intestinal obstruction in patients with an increased risk of this kind of complications, that is, in patients with renal failure, with persistent constipation, in children under 2 years of age or in the elderly.

Aluminum hydroxide is poorly absorbed in the gastrointestinal tract, therefore, systemic action is rarely observed in patients with normal renal function.

However, taking high doses of the drug or its long-term use, as well as the use of recommended doses by patients with a low phosphorus content in the diet or children under 2 years of age, can lead to a phosphate deficiency (due to the ability of aluminum to bind phosphate ions), accompanied by increased bone resorption, hypercalciuria and the risk of osteomalacia. In this regard, it is recommended to consult a doctor in case of prolonged use of the drug, as well as in the case of a risk of phosphate deficiency. In the case of patients with renal insufficiency or those on chronic dialysis, the content of aluminum and magnesium in the preparation must be taken into account. At long-term use in high doses, including high therapeutic doses, development of encephalopathy, dementia, microcytic anemia, or worsening of osteomalacia caused by dialysis is possible.

Patients with mild to moderate renal impairment are advised to take the drug under the direct supervision of a physician. Long-term administration of the drug should be avoided in case of impaired renal function.

Aluminum hydroxide may be unsafe for porphyria patients on hemodialysis.

Wayapplication and dosage

The drug is intended for use only in patients over 15 years of age!

Gastal is intended for oral administration.

The tablet should be gradually dissolved (not swallowed whole), which makes it possible to get a quick effect from taking the drug and makes it more effective.

Take 1-2 tablets no more than 6 times a day (no more than 12 tablets within 24 hours), about 1 hour after meals and in the evening before bedtime (according to the doctor's recommendation, a different dosage regimen may be prescribed!).

With occasional use (for example, with discomfort after errors in the diet) - take 1-2 tablets once.

Pregnancy and breastfeeding

Pregnancy

There are no reliable data on teratogenic effects on animals. To date, in clinical practice, there is no evidence of the development of congenital defects and fetotoxic effects. On the other hand, the possibility of monitoring pregnancies during which the drug has been used is too limited to exclude the possibility of risk. Thus, for safety reasons, the use of the drug during pregnancy is possible only if the potential benefit from its use to the mother justifies the potential risk to the fetus.

Breast-feeding

During treatment, breastfeeding can be continued, since when used as recommended, the absorption of combinations of aluminum hydroxide and magnesium salts in the mother is limited.

Influence on the ability to drive vehicles and use mechanisms

The drug does not affect the ability to manage vehicles and other activities requiring high concentration of attention and speed of psychomotor reactions.

Interaction with other medicinal products

Antacids interact with some other oral medications.

Since aluminum and magnesium salts reduce the gastrointestinal absorption of tetracycline, it is recommended to avoid use during oral therapy tetracyclines.

Combinations requiring safety precautions

WITHquinidine

With simultaneous use with quinidine, an increase in serum concentrations quinidine and the development of quinidine overdose.

In the case of simultaneous oral administration, Gastal can reduce the absorption of various medicines... Therefore, as a precautionary measure, the following drugs are recommended to be taken 2 hours before or 2 hours after taking Gastal:

H2 -antihistamines,ethambutol, isoniazid(orally),atenolol, metoprolol, propranolol, cefdinir, cefpodoxin, chlorohip, cyclins, tetracyclines,diflunisal, digoxin, diphosphonates, iron salts,fluoroquinolones, sodium fluoride,glucocorticosteroids (prednisone anddeceamethasone), indomethacin, ketoconazole, levothyroxine, lincosamides, phenothiazineantipsychotics,penicillamine, rosuvastatin. WITHpolysulfonates (kayeksalats)

When the drug is used together withpolystyrene sulfonates (kayeksalat) followt be careful because of the possible riskdecrease in the efficiency of potassium bindingresin and the development of metabolic alkalosis in patients with renal failure (for aluminum hydroxide and magnesium hydroxide) and intestinal obstruction (for aluminumdroxide).

With citrates

When aluminum hydroxide is combined with citrates, an increase in plasma concentrations of aluminum is possible, which can lead to hyperaluminemia, especially in patients with renal insufficiency.

When taken simultaneously with Gastal, the absorption of the above drugs in the gastrointestinal tract decreases. In the case of a 2-hour interval between taking these drugs and Gastal tablets (and a 4-hour interval between taking fluoroquinolones and Gastal tablets), in most cases this unwanted interaction can be avoided.

Side effects observed with the use of the drug are classified according to the frequency of their occurrence: very often ≥ 10%, often ≥ 1 and< 10%, нечасто ≥ 0,1 и < 1%, редко ≥ 0,01 и < 0,1%, очень редко < 0,01%, частота не известна (частота не может быть оценена на основании имеющихся данных).

Immune system disorders

Frequency unknown: hypersensitivity reactions such as pruritus, urticaria, angioedema, anaphylactic reactions.

Oncollapses from the gastrointestinal tract

Uncommon: diarrhea, constipation.

Metabolic and nutritional disorders

Frequency unknown:

Hypermagnesemia, hyperaluminemia, hypophosphatemia, can develop after prolonged use or use in high doses, as well as use in recommended doses in patients whose diet is characterized by a low phosphorus content or children under two years of age, which can lead to increased resorption processes bone tissue and the occurrence of hypercalciuria with an increased risk of osteomalacia.

Overdose

Experience with deliberate overdose is very limited.

An overdose of aluminum salts can more easily develop in patients with severe renal failure with the following symptoms: encephalopathy, seizures, dementia, and hypermagnesemia.

Symptoms of an acute overdose of a combination of aluminum hydroxide and magnesium hydroxide include, most often, diarrhea, abdominal pain and vomiting.

In patients at risk, taking high doses of the drug may cause or worsen bowel obstruction or intestinal obstruction.

As with all overdose treatment, treatment should be symptomatic and general supportive measures should be taken.

Aluminum and magnesium are excreted in the urine.

Treatment of acute overdose is carried out by replacing fluid loss (rehydration) and forced diuresis. Patients with renal failure require hemodialysis or peritoneal dialysis.

Package

6 tablets in a blister. 2, 4, 5, 8, 10 blisters in a cardboard box together with instructions for use.

Shelf life and storage conditions

Shelf life is 3 years. Do not use the drug after the expiration date.

Store in a place protected from moisture at a temperature not exceeding 25 ° C.

Keep out of the reach of children!

Terms and conditionsdrugstore

Available without a prescription.

Manufacturer

Teva Operation Poland Sr.r.z.o.,

st. Mogilska 80, 31-546 Krakow, Poland.

This article will discuss a common antacid - Gastal, from which it helps, what are the indications for use, composition and contraindications according to the instructions. The medicine itself is round white tablets in a blister of six pieces, intended for resorption. Various flavors are available: mint, cherry, orange and no additives. The manufacturer is TEVA, the factories are located in Poland, Croatia.

Composition and pharmacological properties

The mechanism of action is based on the substances in the composition of Gastal: hydrotalcite 450 mg + magnesium hydroxide 300 mg. Both compounds are classified as non-absorbable antacids. They have a relatively long-term effect, are not absorbed into the bloodstream and do not have an "acid rebound" (when the concentration of hydrochloric acid rises sharply after therapeutic effect).

• Hydrotalcite is an excellent antacid, it has an effect already in the first minutes of its intake, and the maximum effectiveness is achieved within 10 minutes. A complex compound containing aluminum and magnesium ions. It has a strong acid-neutralizing ability, not only reduces acidity, but also contributes to its maintenance at the level of physiological norms. In addition, it has adsorptive properties, binds bile acids and inactivates pepsin, which helps to reduce various dyspeptic manifestations.

Pepsin is a complex substance produced in the stomach that helps break down proteins and has a detrimental effect on the unprotected walls of the mucous membrane. One of the main components of gastric juice.

• Magnesium hydroxide has a quick effect by reducing acidity. It is usually not used on its own, it is part of the preparations together with aluminum, thus, they compensate for each other's shortcomings. For example, magnesium has a weak laxative effect, while aluminum has a fixative effect.

In the complex, the substances complement and strengthen each other, normalizing the acid level, thereby reducing its aggressiveness, eliminating digestive disorders, the risk of developing gastritis. Heartburn, heaviness and pain in the stomach disappear.

When using Gastal, the medium remains slightly acidic, but sufficient to remove all side effects... Due to this, digestion remains at the physiological level, the protective and antimicrobial properties of hydrochloric acid are not lost.

Indications for use

Having dealt with the composition of the Gastal tablets, the indications for use become obvious, according to the instructions, they correspond to many antacids. These are mainly pathologies associated with high level acidity in the stomach, in more detail:

• Gastal is an excellent remedy for heartburn caused by acidity, taking a lot of medications, fatty foods, coffee, nicotine and other reasons.
• Acid-related diseases: gastritis, stomach ulcers and duodenum, GERD. Erosive damage to the mucous membrane of other parts of the gastrointestinal tract.
• Treatment of dyspeptic disorders, digestive disorders.
• Helps with nausea, especially with a minty flavor.
• Pain and heaviness in the epigastric region.
• Diaphragmatic hernia.
• In case of errors in the applied diet, to eliminate unpleasant symptoms.
• Reception is possible from the consequences of food poisoning.

The epigastric region is the projection area of ​​the stomach on abdominal wall... Located in the middle of the body, just below the ribcage.

Contraindications

Gastal should not be used with high sensitivity to magnesium and aluminum salts, diseases associated with them:

• Alzheimer's disease - it has been proven that aluminum has a detrimental effect on the condition of patients.
• Hypophosphatemia - low levels of phosphates in the blood. Antacids are capable of binding and excreting through the intestines a large number of phosphates.
• Severe renal dysfunction.
• Age up to 6 years.

Mode of application

Gastal tablets should be dissolved until completely dissolved, the instruction does not recommend chewing it. With a body weight of more than 50 kg, the daily dosage can reach 8 tablets, but usually they drink one 3-4 times, preferably one hour after meals and before bedtime.

If the body weight is less than 50 kg, as well as for children under 12 years of age, the recommended dosage is halved, usually two to three tablets.

You can buy Gastal without a doctor's prescription, but you cannot take it for more than two weeks, as there is a risk of side effects.

Gastal is considered safe drug, cases of overdose practically do not occur. With prolonged use in large quantities, it can cause various symptoms: diarrhea, constipation, decreased blood pressure, hypophosphatemia, hypocalcemia, impaired renal function. Treatment in such cases is symptomatic.

special instructions

When using it, it should be borne in mind that aluminum and magnesium can react with various chemical compounds of other drugs. This must be taken into account in the concomitant treatment of other diseases. For example, it is forbidden to use Gastal together with antibiotics, especially: Tetracycline, Ciprofloxacin, Doxycycline, since their effectiveness will drop by 70-90%. You need to be careful when taking pills from arterial hypertension: Capoten, Captopril, Metoprolol.

In order to prevent drug interactions, it is necessary to pause 1-2 hours after taking the pills or, if the risk is high, to give up antacids altogether.

Analogs

There are antacids on the market that are similar in composition to Gastal, analogues cheaper in price sometimes help no worse, but everything is individual. Gastal itself can be considered an inexpensive drug, especially if you use it for heartburn, if necessary, you can purchase a small package No. 12. Complete analogues the drug (hydrotalcide + magnesium hydroxide), as well as domestic manufacturers, does not exist.

Write in the comments.

Do not hesitate to understand the problem of interest to you together.

Consider identical means, many can be considered such with the combined action of magnesium and aluminum:

• Maalox.
• Almagel.
• Gastricide.
• Alumag.

• Talcid.
• Rutacid.

Similar can also be attributed to: Rennie, Relzer, Tams, Gaviscon and others, but they already differ significantly.

Let's consider some analogs in more detail:

Conclusion

In conclusion, we can say that Gastal is an excellent medicine from the group of antacids, coping well with the signs of gastritis, heartburn, indigestion, nausea and other unpleasant symptoms of diseases of the digestive system. Well tolerated by the body, provided there are no severe kidney complications.

It is worth recalling that the duration of the course should not exceed 14 days, if the desired effect does not occur, it is recommended to consult a doctor.

Perhaps each of us is familiar with discomfort in the stomach and intestines. In everyday life, we eat the wrong foods, our diet is completely unbalanced, and it often happens that we choose fast food as a snack. All this affects the condition of the gastrointestinal tract. In addition to improper nutrition, the gastrointestinal tract is influenced by stressful situations, Lifestyle, bad habits... Many of us take Gastal for stomach or intestinal discomfort. What does this pharmacological agent help from?

Gastal refers to pharmacological group drugs of the antacid type. This pharmaceutical preparation contains substances that have a beneficial effect on the gastric mucosa, in particular:

• magnesium hydroxycate aluminum carbonate gel;
• magnesium hydroxide;
• additional substances.

When Gastal tablets enter the body due to active substances, hydrochloric acid in the stomach binds, thereby eliminating discomfort and normalizing natural digestive processes. As practice shows, most often Gastal is taken by people who experience painful sensations in the stomach after eating fatty or spicy foods, as well as from heartburn and after excessive alcohol consumption in order to remove toxins.

Due to the binding of free hydrochloric acid in the gastric cavity, Gastal helps to normalize the alkaline-acid balance, which allows you to get rid of painful and uncomfortable sensations. Often, such a drug is taken by people adhering to a dietary diet. If you are on a diet to get rid of excess weight, but by chance you had a breakdown and you ate 1-2 cakes, then there is nothing wrong with that - you can take the Gastal pill, which will allow you to digest the food you received faster.

Indications for the use of Gastal

As already mentioned, Gastal has a very good effect on the stomach, binding free hydrochloric acid. The pharmacological agent begins to act almost immediately after it enters the digestive tract. The antacid effect lasts an average of 2 hours. Thanks to its active substances, Gastal inhibits the production of a number of enzymes, in particular, lysolecithin and pepsin, and also minimizes the effect of bile acid on the mucous membrane of the esophagus and stomach. According to the instructions, Gastal is recommended to be taken in such cases:

• in case of gastritis of the hyperacid type;
• in case of detection of ulcerative pathologies of the stomach or duodenum;
• with diaphragmatic hernia;
• in case of belching or heartburn;
• with acute pancreatitis;
• in case of development of cholecystitis;
• with the development of erosive processes in the esophagus;
• with vagrant dyspepsia;
• in case of food or other poisoning;
• with a disease of gastroesophageal reflux pathology;
• in the case of a syndrome of retention of gastric excretion.

As already mentioned, Gastal helps well with heartburn, as well as with alcohol intoxication. If in the morning a person experiences hangover syndrome, then with the help of this pharmacological drug, you can quickly get rid of toxins.

How to take Gastal?

Gastal can be purchased at any pharmacy. This pharmaceutical product is available in tablet form. Dosage form Gastal has the same, the difference is the flavoring and the number of tablets in the package. On pharmacy counters you can find packages with the number of tablets 12, 24, 30 and 48 pieces. The most common Gastal tablets are tasteless and are usually coated. But manufacturers also offer cherry and mint flavored tablets. Most often, these pharmacological agents are purchased for children.

Before purchasing and taking Gastal, consult with your doctor, since this drug has a number of contraindications, and excessive or improper use of it can lead to side effects. Pay attention to the expiration date and release date. Gastal should be stored in a cool place, protected from children's access and direct sunlight. You should also observe the established temperature threshold for storing the drug. The course of treatment cannot exceed 14 days, since Gastal is taken exclusively for therapeutic purposes.

It is recommended to take the medicine one hour after a meal or one hour before a night's sleep. In any case, it is best to consult a gastroenterologist before starting a treatment course. Adults are allowed to use 2 tablets no more than 3 times a day. For children age category from 6 to 12 years old, it is allowed to take no more than 1 tablet three times a day. The treating experts do not advise giving such a drug to children under the age of six. You do not need to drink a liquid or swallow a pill. Her pharmacological form provides for resorption. The tablet should be placed on the cheek or under the tongue: the active substances will begin to be absorbed into the mucous membrane within a few minutes and, together with the saliva produced, will enter the esophagus and stomach.

If the severity and discomfort in the gastrointestinal tract is due to overeating or consumption alcoholic beverages, then you can take one tablet of Gastal. As practice shows, a person feels relief after a few minutes.

Contraindications to taking Gastal

If you carefully read the instructions for this pharmacological agent, then read the list of contraindications. So, Gastal is strictly forbidden to use in such cases:

• with the progression of Alzheimer's disease;
• in case of individual intolerance to individual components, in particular lactose;
• in the case of renal failure, with the course of the pathology in a severe form;
• in case of an allergic reaction to the constituent components and active substances.

Doctors-gastroenterologists advise not to take such a drug to people in old age, as well as to women during the period of gestation. In practice, there were cases when the reception of Gastal caused the appearance of diarrhea, constipation, nausea and a change in taste perception.

Side effects

Taking the pharmacological drug Gastal can also provoke the development of side effects. Typically, they can occur with the wrong dosage or overuse tablets. Treating specialists and leading pharmacists distinguish the following side effects drug:

• nausea;
• manifestation of allergic reactions in various forms;
• the development of osteoporosis;
• diarrhea;
• encephalopathy;
• constipation;
• disruption of the normal functioning of the kidneys;
• osteomalacia;
• nephrocalcinosis;
• hypercalciuria.

If Gastal is taken by people suffering from kidney failure, then as side effects, they may experience an increase in the level blood pressure and constant thirst... In this case, you need to immediately contact the attending specialist and undergo a full-scale study in order to prescribe a full and balanced treatment course.

In case of an overdose of Gastal, the above side effects may occur. It is better not to take Gastal with other medicines at the same time. The interval between the reception of various pharmaceuticals should be at least 2 hours.

Gastal does a very good job with various diseases Gastrointestinal tract. Spectrum pharmacological action this drug is wide enough. Do not practice self-treatment... A correct, balanced and effective treatment course can only be prescribed by a specialist.

Release form

Pills

Composition

1 lozenge contains: Active substances: aluminum hydroxide-magnesium carbonate gel 450 mg, magnesium hydroxide 300 mg, Excipients: mannitol (E421), sorbitol (E420), lactose monohydrate, corn starch, sodium cyclamate, sodium saccharinate, talc, magnesium stearate, peppermint flavor.

Pharmacological effect

Combined antacid. Reduces the increased acidity of gastric juice and does not have a stimulating effect on the secretion of gastric juice. Aluminum hydroxide-magnesium carbonate gel and magnesium hydroxide provide immediate (immediately after ingestion) and prolonged (about 2 hours) neutralization of gastric acid hydrochloric acid, while maintaining acidity in the stomach at a physiological level (pH 3-5). 1 tablet of Gastal neutralizes about 21.5 mmol of hydrochloric acid. Gastal suppresses the action of pepsin, lysolecithin and bile acids, eliminates dyspeptic symptoms. Strengthens the protective and regenerative processes in the gastric mucosa. Aluminum ions have a cytoprotective effect by increasing the secretion of mucin and sodium bicarbonate, activating prostaglandin E2 and NO, accumulating epidermal growth factor at the site of mucosal injury, and increasing the concentration of phospholipids in the stomach wall.

Pharmacokinetics

Gastal has no systemic effect in patients with normal renal function. After interaction with hydrochloric acid of gastric juice, aluminum hydroxide reacts with phosphates and carbonates in the alkaline medium of the intestine and is excreted in the feces in the form of insoluble salts. Magnesium hydroxide reacts with hydrochloric acid in gastric juice to form magnesium chloride, which has osmotic properties and a mild laxative effect, which neutralizes the fixing effect of aluminum hydroxide in small intestine... Magnesium is excreted in the feces as insoluble carbonate.

Indications

Dyspeptic phenomena such as discomfort or pain in the epigastrium, heartburn, sour belching after errors in the diet, excessive consumption of ethanol, coffee, nicotine. Dyspeptic phenomena such as discomfort or pain in the epigastrium, heartburn, sour belching (and their prevention) occur as a result of some drugs(NSAIDs, GCS) Conditions accompanied by increased acidification: peptic ulcer stomach, gastritis, reflux esophagitis. hernia of the esophageal opening of the diaphragm.

Contraindications

Hypersensitivity to the components of the drug. Severe renal failure. Hypophosphatemia. Fructose intolerance (due to the presence of sorbitol in the preparation). Childhood up to 12 years old. With caution: in case of renal failure (with prolonged use, an increase in the content of magnesium and aluminum in the blood plasma is possible). With Alzheimer's disease. With a low content of phosphates in food (risk of developing phosphate deficiency).

Precautionary measures

The drug should be used with caution in chronic renal failure, during pregnancy and during breastfeeding, in adults and children over 12 years old with a body weight of less than 50 kg, in children aged 6 to 12 years, in elderly patients.

Application during pregnancy and lactation

The use of the drug during pregnancy and lactation (breastfeeding) is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus. Gastal is not excreted in breast milk.

Method of administration and dosage

Inside, gradually dissolving in the mouth. Adults and children over 12 years of age weighing at least 50 kg: 1-2 tablets 4-6 times a day approximately 1 hour after meals and before bedtime, but no more than 8 tablets per day. Duration of admission is no more than 2 weeks. Similar doses are recommended for treating heartburn regardless of food intake. Adults and children over 12 years of age weighing less than 50 kg, children aged 6 to 12 years: The dose is half the recommended dose for adults. Duration of admission is no more than 2 weeks.

Side effects

Overdose

Symptoms of acute overdose have not been described. Symptoms: with prolonged use of high doses of drugs containing aluminum and magnesium, hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, hypermagnesemia, hyperaluminaemia, encephalopathy, nephrocalcinosis and renal impairment are possible. Possible increased side effects from digestive system(constipation, diarrhea). In patients with renal insufficiency, thirst, lowering blood pressure, hyporeflexia are possible. Treatment: carrying out symptomatic therapy.

Interaction with other drugs

Gastal, with simultaneous use, enhances the activity of levodopa and nalidixic acid, reduces and slows down the absorption of quinolones, isoniazid, naproxen, iron preparations, indomethacin, chlorpromazine, beta-blockers, diflunisal, histamine H2 receptor blockers, fat-soluble vitamins, indirect anticoagulants, barbiturates. When interacting with metal ions that make up antacids, tetracyclines form insoluble chelate complexes; as a result of this interaction, the absorption of tetracyclines is reduced by more than 90%. Simultaneous reception these drugs are not possible. If necessary, the combined use of tetracycline should be taken at least 2 hours before taking the antacid. In the presence of aluminum hydroxide and magnesium hydroxide contained in the Gastal preparation, the absorption of ciprofloxacin and ofloxacin is reduced by 50-90%. In the presence of antacids, the bioavailability of captopril is significantly reduced, and the combined use of antacids and metoprolol leads to a decrease in the concentration of metoprolol in the blood plasma. With the simultaneous use of antacids in high doses, it is possible to reduce the absorption of ranitidine by 10-33%. The use of antacids does not affect the bioavailability of amoxicillin, cephalexin and the combination of amoxicillin and clavulanic acid, however, it can significantly reduce the absorption of doxycycline from the gastrointestinal tract. An increase in urine pH during antacid therapy can increase the tubular reabsorption of alkaline drugs and reduce the reabsorption of acidic compounds. Antacids can reduce and slow down the absorption of salicylates, incl. acetylsalicylic acid, as well as, by increasing the pH of urine, to promote a more rapid excretion of salicylates in the urine from the body, with a concomitant decrease in their concentration in the blood serum by 30-70%. Absorption of cardiac glycosides, incl. digoxin and digitoxin, when used simultaneously with antacids, does not significantly decrease. M-anticholinergics, slowing down gastric motility, increase the duration of the action of the drug Gastal. In order to prevent possible interaction of Gastal with other drugs, it is recommended to take it 1 hour before or 1 hour after their use.

special instructions

The recommended dose and duration of treatment should not be exceeded when used in patients with impaired renal function. Influence on the ability to drive vehicles and control mechanisms: The use of the drug Gastal does not affect the ability to drive vehicles and control other mechanisms.

An antacid medicine that is used for gastritis and stomach ulcers is Gastal. The instructions for use indicate that the resorption tablets neutralize the hydrochloric acid of gastric juice well. Doctors - gastroenterologists show in their reviews that the medicine helps in the treatment of heartburn.

Release form and composition

Gastal is available in the form of lozenges. One tablet contains a gel of aluminum hydroxide-magnesium carbonate - 450 mg and magnesium hydroxide - 300 mg.

The tablets have a rounded shape, smooth surface and white (creamy) color. They are packaged in a blister of 6 pieces. The cardboard box contains 2,4,6, 8 or 10 blisters with the corresponding number of tablets and instructions for use of the drug.

pharmachologic effect

Its active components neutralize gastric acid hydrochloric acid, reducing its irritant effect on the mucous membrane digestive tract... The resulting insoluble magnesium salts relax the intestinal smooth muscles and have a mild laxative effect.

Aluminum salts absorb large amounts of water, forming an additional protective local anesthetic film on the mucous membrane. The therapeutic effect is manifested immediately after taking the drug. The time spent in the stomach depends on its evacuation activity and ranges from 1 to 2 hours. Gastal is not absorbed into the systemic circulation and does not cause alkalosis.

Indications for use

What does Gastal help from? Indigestion, heartburn, pain and discomfort in the stomach are all that pills are good for.

Clinical indications for the use of Gastal are:

• diseases characterized by increased acid production: gastritis, gastric ulcer, reflux esophagitis;
• the phenomena of dyspepsia, such as epigastric pain, heartburn, discomfort, sour belching after drinking alcohol, coffee, inaccuracies in the diet, nicotine, and also arising after taking a number of drugs.

Instructions for use

Gastal is taken orally. The tablet should be gradually dissolved (not swallowed whole). Adults are recommended to take 1-2 tablets 4-6 times a day 1 hour after a meal and before bedtime, but no more than 8 tablets within 24 hours. The duration of administration should not exceed 2 weeks.

For prophylaxis, Gastal is used before the expected irritant effect on the gastrointestinal mucosa. Similar doses are recommended for heartburn, regardless of food intake. For children aged 6-12 years, half of the adult dose is recommended.

Contraindications

Gastal is contraindicated:

• with hypophosphatemia;
• children under 6 years old;
• with chronic renal failure;
• with Alzheimer's disease;
• at hypersensitivity to one of the components of the drug.

The drug can be used with caution in children under 12 years of age. Gastal during pregnancy and breastfeeding can be taken, but only under the supervision of a doctor. The negative effects of taking Gastal during pregnancy have not been studied.

Side effects

Gastal tablets are well tolerated; when used in recommended therapeutic doses, side effects practically do not develop. Rarely, nausea, vomiting, constipation or diarrhea, and a change in taste develop.

It is extremely rare to be allergic reactions in the form of a skin rash, itching or hives (a characteristic rash and itching, reminiscent of a nettle burn).

Children, during pregnancy and breastfeeding

As with the appointment of all other drugs, the use of Gastal during pregnancy is possible only in special cases and only on the recommendation of a doctor. Use with caution in children under 12 years of age.

special instructions

For long-term treatment with Gastal, serious indications are required. Adults weighing less than 50 kg and children under 12 years of age may require reduced doses and a shorter treatment period.

Drug interactions

There is a weakening of absorption from the gastrointestinal tract of drugs taken simultaneously with Gastal. Therefore, it is necessary to take a break between taking various medications.

Analogues of the drug Gastal

1. Acrepat Forte (suspension).
2. Almagel (suspension).

The group of antacids includes analogues:

1. Magnatol.
2. Talcid.
3. Tannakp.
4. Flax seeds.
5. Becarbon.
6. Andrews liver salt.
7. Gastricide.
8. Gasterin.
9. Magnistad.
10. Topalkan.
11. Rutacid.
12. Scoralight.
13. Magnesium oxide.
14. Rivolox.
15. Alumag.
16. Rockjel.
17. Tams.
18. Calcium carbonate.
19. Gelusil.
20. Daijin.
21. Gelusil.
22. Andrews antacid.
23. Gastric.
24. Almol.
25. Gastroromazole.
26. Almagel.
27. Adjiflux.
28. Alyugastrin.
29. Relzer.
30. Tisacid.
31. Gaviscon forte.
32. Gelusil varnish.
33. Maalox mini.
34. Antareit.
35. Alfogel.
36. Sodium bicarbonate.
37. Gestide.
38. Rennie.
39. Aktal.
40. RioFast.
41. Almagel Neo.
42. Phosphalugel.
43. Magalfil 800.
44. Sodium bicarbonate.
45. Anacid forte.

Vacation conditions and price

The average cost of Gastal (tablet number 12) in Moscow is 167 rubles. Available without a prescription.

The shelf life of Gastal tablets is - years from the date of their release. It is necessary to store the drug in a dark, dry place at an air temperature not higher than +25 C. Keep out of the reach of children.

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