Cetirizin Sandoz: Instructions for use. Cetirizin Sandoz - Instructions for use, doses, side effects, contraindications, the price where to buy - Drug Hader Drug Reference to Application
Dosage form
Drops for intakes in the form of a transparent, colorless solution without extraneous particles.
Structure
Cetirizina Dihydrochloride 10 mg
Auxiliary substances: glycerol 85% - 125 mg, propylene glycol - 125 mg, distilled water - 765.6 μg, sodium acetate trihydrate - 15 mg.
Pharmacodynamics
Histamine H1 receptor blocker. It has an antiallergic effect. Practically does not have a sedative effect when applied in recommended doses and practically does not have anticholinergic and antiserotonin action, warns development and facilitates the current allergic reactions. He has a contamination and anti-dispersonal effect.
Affects early Stadium allergic reactions, as well as reduces the migration of inflammation cells; Inhibits the release of mediators involved in the late allergic reaction. Reduces the permeability of capillaries, warns the development of tissue edema, removes the spasm of a smooth muscles. Eliminates the skin reaction to the introduction of histamine, specific allergens, as well as cooling (with a cold urticule). Cetirizin significantly reduces the hyperreactivity of the bronchial tree, arising in response to the release of histamine in patients bronchial asthma.
The therapeutic effect of the drug is manifested on average 60 minutes after reception. Against the backdrop of the course reception, tolerance does not develop.
Pharmacokinetics
Suction
After taking inside the cetirizin quickly and quite fully absorbed from the gastrointestinal tract. Cmax is achieved in 40-60 minutes.
Meal does not have a significant effect on the absorption value, but in this case the suction rate is slightly reduced.
Distribution
Bonding with plasma proteins is approximately 93%. VD is low and is 0.5 l / kg. Cetirizine does not penetrate the BC and inside the cells.
Metabolism
Cetirizine is substantially metabolized in the liver with the formation of an inactive metabolite. When applied at a dose of 10 mg / day for 10 days, the cumulation is not observed.
Election
It is removed mainly by the kidneys (70%) mainly unchanged. Systemic clearance is about 54 ml / min. After one-time reception at a dose of 10 mg T1 / 2, it is about 10 hours.
Pharmacokinetics in special clinical cases
Children aged 2 to 12 years old T1 / 2 decreases to 5-6 hours.
With a pronounced violation of the kidney function (KK 11-31 ml / min) and in patients on hemodialysis (QC less than 7 ml / min), T1 / 2 increases 3 times, systemic clearance decreases by 70%.
Against the background of chronic diseases and in elderly people, there is an increase in T1 / 2 by 50% and a reduction in systemic clearance by 40%.
Side effects
From side digestive system: dry mouth, dyspepsia.
From the CNS: headache, drowsiness, fatigue, dizziness, excitement, migraine.
For more information, see instructions
Features of sale
Released without recipe
Special conditions
Against the background of the use of the drug should not be used ethanol.
Impact on the ability to driving vehicles and control mechanisms
During the use of the drug, it is necessary to refrain from classes potentially hazardous species Activities requiring increased concentration of attention and speed of psychomotor reactions.
Indications
Year-round and seasonal allergic rhinitis (as symptomatic therapy);
Urticaria (including chronic idiopathic);
Dermatoz leaking with itching (including atopic dermatitis, neurodermit);
Allergic conjunctivitis.
Contraindications
Increased sensitivity relative to cetirizin or other components of the drug; Heavy kidney diseases.
Childhood up to 1 year.
Pregnancy, lactation period.
With caution: chronic pyelonephritis of medium and severe severity (the correction of the dosage mode is required), elderly age (It is possible to reduce glomerular filtration).
Medicinal interaction
Not established clinically significant interactions of Cetirizin with others drugs.
The co-use with theophylline (400 mg / day) leads to a decrease in the general clearance of cetirizin (the kinetics of theophylline does not change).
For details, see Instructions
Prices for Cetirizin in other cities
Active substance
Cetirizina Dihydrochloride (Cetirizine)
Release form, composition and packaging
◊ Shell-covered tablets White or almost white color, oblong, with a notch on one side.
Auxiliary substances: monohydrate lactose - 80 mg, microcrystalline cellulose - 23.8 mg, silicon colloidal dioxide - 600 μg, magnesium stearate - 600 μg.
The composition of the shell: The dying is the dedry white (monohydrate lactose - 1.8 mg, titanium dioxide - 1.3 mg, hypimosellos - 1.4 mg, macrogol 4000 - 500 μg) - 5 mg.
7 pcs. - Packaging cell contour (1) - packs cardboard.
7 pcs. - Packaging cell contour (2) - packs cardboard.
7 pcs. - Packaging cell contour (3) - packs cardboard.
7 pcs. - Packaging cell contour (5) - packs cardboard.
10 pieces. - Packaging cell contour (2) - packs cardboard.
10 pieces. - Packaging cell contour (3) - packs cardboard.
10 pieces. - Packaging cell contour (5) - packs cardboard.
10 pieces. - Packaging cell contour (1) - packs cardboard.
◊ Drops for reception inside In the form of a transparent, colorless solution without extraneous particles.
Auxiliary substances: benzoic acid - 2 mg, glycerol 85% - 125 mg, propylene glycol - 125 mg, distilled water - 763.6 μg, sodium acetate trihydrate - 15 mg.
10 ml - Dark Glass Drops (1) - Cardboard Boxes.
20 ml - Dark Glass Drops (1) - Cardboard Boxes.
◊ Syrup Transparent, colorless, without outsided particles, with a banana smell.
Auxiliary substances: sorbitol 70%, glycerol 85%, propylene glycol, sodium acetate, methyl aprichedroxybenzoate, propyl aprichedroxybenzoate, sodium saccharin, acetic acid 20%, Banana flavoring.
75 ml - dark glass vials (1) complete with a measuring spoon (5 ml) - cardboard packs.
150 ml - dark glass vials (1) complete with a measuring spoon (5 ml) - packs cardboard.
pharmachologic effect
Blocator histamine H 1 -receptors. It has an antiallergic effect. It practically does not have a sedative effect when applied in the recommended doses and practically does not have anticholinergic and antiserotonin action, prevents development and facilitates the course of allergic reactions. It has both an anti-discharge effect.
Affects the early stage of allergic reactions, and also reduces the migration of inflammation cells; Inhibits the release of mediators involved in the late allergic reaction. Reduces the permeability of capillaries, warns the development of tissue edema, removes the spasm of a smooth muscles. Eliminates the skin reaction to the introduction of histamine, specific, as well as for cooling (with a cold urticule). Cetirizine significantly reduces the hyperreactivity of the bronchial tree, arising in response to the release of histamine in patients with bronchial asthma.
The therapeutic effect of the drug is manifested on average 60 minutes after reception. Against the backdrop of the course reception, tolerance does not develop.
Pharmacokinetics
Suction
After taking inside the cetirizin quickly and quite fully absorbed from the gastrointestinal tract. C MAX is achieved in 40-60 minutes.
Meal does not have a significant effect on the absorption value, but in this case the suction rate is slightly reduced.
Distribution
Medicinal interaction
Not established clinically significant interaction of cetirizin with other drugs.
The co-consumption with theophylline (at a dose of 400 mg / day) leads to a decrease in the general clearance of cetirizin (the kinetics does not change).
special instructions
Against the background of the use of the drug should not be used ethanol.
When prescribing the drug patients diabetes It should be borne in mind that 1 tablet corresponds to less than 0.01 x, 10 ml of syrup (2 dimensional spoons) contain 3.15 g of sorbitol (800 mg of fructose), which corresponds to 0.026 x.
Impact on the ability to driving vehicles and control mechanisms
During the use of the drug, it is necessary to refrain from practicing potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Pregnancy and lactation
The drug is contraindicated to use during pregnancy. If necessary, prescribing the drug during the lactation period should be resolved breastfeeding.
Childcare
The drug in the form of droplets for intakes is intended for children over the age of 1 year.
The preparation in the form of a syrup is intended for children over the age of 2 years.
The preparation in the form of tablets is designed for children over the age of 6.
With violations of the kidney function
Contraindicated in severe kidney diseases.
Caution prescribed the drug when chronic pyelonephritis Middle and severe severity (needed correction of the dosing mode), elderly persons (due to a possible reduction in glomerular filtration in this category of patients).
1 Tablet covered with a shell contains:
- Active substitute: Cetirizin Dihydrochloride 10 mg.
- Auxiliary substances: starch premaritalized, monohydrate lactose, starch, povidone (K30), sodium carboxymethyl starch, silicon colloidal, magnesium stearate.
- Shell: HalpRellos, macrogol 6000, titanium dioxide, talc, aluminum varnish based on punch dye (punching 4R).
Packing 10 pcs.
1 ml drops for receiving inside contains:
- active substance: Cetirizin Dihydrochoride - 10 mg;
- auxiliary substances: glycerol 85% - 125 mg, propylene glycol - 125 mg, sodium acetate trihydrate - 15 mg, water - 765.6 μl.
Description of the dosage form
Sheath-covered tablets.
Transparent, colorless solution without extraneous particles.
pharmachologic effect
Antiallergic, H1-antihistamine.
Pharmacokinetics
The pharmacokinetic parameters of cetirizin at its reception in doses from 5 to 60 mg change linearly.
Suction
Tmax in blood plasma is (1 ± 0.5) h, and Cmax - 300 ng / ml.
Pharmacokinetic parameters such as Cmax in blood plasma and AUC are homogeneous. Eating does not affect the completeness of Cetirizin absorption, although its speed is reduced. The bioavailability of various dosage forms of cetirizine is comparable.
Distribution
Cetirizine on (93 ± 0.3)% binds to blood plasma proteins. VD is 0.5 l / kg. Cetirizine does not affect the binding of warfarin with proteins.
Metabolism
Cetirizine is not exposed to extensive primary metabolism.
Election
T1 / 2 is about 10 hours.
When taking cetirizin in a daily dose of 10 mg for 10 days, the cumulation was not observed.
Approximately 2/3 of the adopted dose is displayed with urine unchanged.
Special groups of patients
Elderly. In 16 elderly, with a single reception of cetirizin at a dose of 10 mg T1 / 2, it was 50% higher, and the clearance was below 40% compared with the persons of the insignificant age.
Reducing Cetirizin clearance in elderly patients is probably due to a decrease in the kidney function in this category of patients.
Renal failure. In patients with renal failure of easy severity (CL creatinine\u003e 40 ml / min) Pharmacokinetic parameters are similar to those in healthy volunteers with a normal kidney function.
In patients with renal failure middle degree gravity and patients on hemodialysis (CL creatine
For patients with renal failure of medium or severe, the corresponding change in the dosage mode is required.
Cetirizine is poorly removed from the organism during hemodialysis.
Liver failure. In patients with chronic liver diseases (hepatocellular, cholestatic and biliary cirrhosis) with a single reception of cetirizine in a dose of 10 or 20 mg T1 / 2 increases by about 50%, and the clearance decreases by 40% compared with healthy subjects. Dose correction is necessary only if the patient with hepatic insufficiency There is also a concomitant renal failure.
Children. T1 / 2 in children from 6 to 12 years old is 6 hours, from 2 to 6 years - 5 hours, from 6 months to 2 years - reduced to 3.1 hours.
Pharmacodynamics
Cetirizine is a hydroxyzine metabolite, refers to the group of competitive histamine antagonists and blocks H1-histamine receptors.
In addition to the antihistamine effect, Cetirizine prevents development and facilitates the course of allergic reactions: in a dose of 10 mg 1 or 2 times a day, inhibits the late phase of the hydrogenation of eosinophils in the skin and the conjunctivation of patients with allergic reactions.
Clinical Efficiency and Security
Research in healthy volunteers have shown that cetirizine when taking in doses of 5 or 10 mg significantly inhibits the reaction in the form of rash and redness to the introduction of histamine in high concentration into the skin, but the correlation with efficiency is not established. In a 6-week placebo-controlled study with the participation of 186 patients with an allergic rhinitis and a concomitant bronchial asthma of light and medium-free flow, it was shown that the reception of cetirizine at a dose of 10 mg 1 time per day reduces the symptoms of rhinitis and does not affect the function of the lungs.
results this study Confirm the safety of the use of cetirizin in patients suffering from allergies and bronchial asthma of light and medium-free flow.
The placebo-controlled study shows that the reception of cetirizine at a dose of 60 mg / day for 7 days did not cause clinically significant elongation of the Qt interval. Cetirizin intake at the recommended dose showed an improvement in the quality of life of patients with year-round and seasonal allergic rhinitis.
Children. In a 35-day study with the participation of patients 5-12 years, no signs of immunity to the antihistamine effect of cetirizine were not identified. Normal skin reaction to histamine was restored for 3 days after the cancellation of the means during its repeated use.
In a 7-day placebo-controlled Cetirizin study, in dosage form Syrup, with the participation of 42 patients aged from 6 to 11 months, the safety of its use is demonstrated. Cetirizin was prescribed at a dose of 0.25 mg / kg 2 times a day, which approximately corresponded to 4.5 mg per day (the dose range was from 3.4 to 6.2 mg per day).
Indications for use Cetirizin Sandoz
To facilitate nasal and eye symptoms year-round (persistent) and seasonal (intermittent) allergic rhinitis and allergic conjunctivitis (itching, sneezing, nasal conjunction, rhinora, tearing, hyperemia conjunctiva); Symptoms of half aulinosis (hay fever); Symptoms of urticaria (including chronic idiopathic), other allergic dermatoses, incl. allergic dermatitisaccompanied by itching and rash, in adults and children from 6 months (in the form of droplets) or from 6 years (in the form of tablets).
Application in children from 6 to 12 months is possible only by the appointment of a doctor and under strict medical control.
Contraindications for use Cetirizin Sandoz
Increased sensitivity to cetirizin, hydroxyzine or any piperazine derivative; Terminal Stage renal failure (Cl creatinine
With caution: Chronic renal failure (CL creatinine\u003e 10 ml / min, the dosing mode correction is required); elderly patients (with age reduction of glomerular filtration); epilepsy and patients with elevated convulsive readiness; Patients with factors predispose to urine delay; age up to 1 year (for the dosage form of a drop); Breastfeeding period.
Cetirizin Sandoz Application during pregnancy and children
In analyzing prospective data, more than 700 cases of pregnancy outcomes were not identified cases of formation of malformations, embryonic and neonatal toxicity with a clear causal relationship with the use of cetirizin.
Experimental studies on animals did not reveal any direct or indirect adverse effects of cetirizin on developing fruit, pregnancy and postnatal development.
Adequate and strictly controlled clinical studies The safety of the use of cetirizin during pregnancy was not carried out, so it should not be applied during pregnancy.
Cetirizine stands out by S. breast milk - from 25 to 90% of its concentration in the blood plasma, depending on the time after the appointment. In the period of breastfeeding, they are used after consulting a doctor if the intended benefit for the mother exceeds the potential risk for the child.
Fertility. Available data on the effect on human fertility is limited, but a negative effect on fertility has not been detected.
Cetirizin Sandoz Side effects
Data obtained in clinical studies
The results of clinical studies have demonstrated that the use of cetirizine in recommended doses leads to minor development unwanted effects on CNS, including drowsiness, fatigue, dizziness and headache. In some cases, paradoxical stimulation of the CNS was registered.
Despite the fact that Cetirizine is a selective blocking of peripheral H1 receptors and practically does not have an anticholinergic effect, it has been reported on isolated cases of urination, acceleration disorders and dryness in the mouth.
It has been reported violations of the liver function, accompanied by an increase in the level of hepatic enzymes and bilirubin. In most cases, unwanted phenomena were resolved after the cessirizin reception.
List of undesirable adverse Reactions. There are data obtained during double-blind controlled clinical studies aimed at comparing Cetirizin and placebo or other antihistamine drugs used in the recommended doses (10 mg 1 time per day for cetirizin) more than 3200 patients, on the basis of which it is possible to carry out a significant analysis Safety data.
According to the results of the combined analysis, in placebo-controlled studies, when applying cetirizine at a dose of 10 mg (n \u003d 3260) and placebo (N \u003d 3061), the following unwanted reactions with a frequency of 1% or higher were revealed.
General disorders and disorders at the injection site: fatigue - 1.63 and 0.95%.
From side nervous system: dizziness - 1.1 and 0.98%; Headache - 7.42 and 8%.
From the gastrointestinal tract: abdominal pain - 0.98 and 1.08%; dry mouth - 2.09 and 0.82%; Nausea - 1.07 and 1.14%.
From the psyche side: drowsiness - 9.63 and 5%.
From the respiratory system, organs chest and mediastinum: pharyngitis - 1.29 and 1.34%.
Although the frequency of cases of drowsiness in the cetirizin group was higher than this in the placebo group, in most cases this undesirable phenomenon was an easy or moderate severity. For objective assessmentconducted within the framework of other studies, it was confirmed that the use of cetirizine in the recommended daily dose in healthy young volunteers does not affect their daily activity.
Children. In placebo-controlled studies in children between the ages of 6 months to 12 years, the following undesirable reactions with a frequency of 1% and higher in groups taking cetirizine (n \u003d 1656) and placebo (n \u003d 1294) were revealed.
From the gearbox: diarrhea - 1 and 0.6%.
From the psyche side: drowsiness - 1.8 and 1.4%.
From the side of the respiratory system, chest and mediastum organs: rhinitis - 1.4 and 1.1%.
General disorders and disorders at the injection site: fatigue - 1 and 0.3%.
Experience of post-registration application
In addition to unwanted phenomena, the following undesirable reactions were observed in the framework of clinical studies and described above, within the framework of the finalization of cetirizin, the following undesirable reactions were observed.
Unwanted phenomena are presented below by the classes of the system of the MEDDRA organs and the development frequency, on the basis of the data of the post-registration application of cetirizin.
The frequency of the development of unwanted phenomena was determined as follows: Very often (≥1 / 10); Often (≥1 / 100,
From blood and lymphatic system: Very rarely thrombocytopenia.
From side immune system: rarely - hypersensitivity reactions; Very rarely - anaphylactic shock.
Violation of metabolism and nutritional disorders: the frequency is unknown - an increase in appetite.
From the psyche: infrequently - excitement; rarely - aggression, confusion of consciousness, depression, hallucination, sleep disorder; very rarely - tick; The frequency is unknown - suicidal ideas.
From the side of the nervous system: infrequently - paresthesia; rarely - convulsions; Very rarely - the perversion of taste, dyskinesia, dystonia, fainting, tremor; The frequency is unknown - a violation of memory, incl. amnesia.
From the side of the organ of vision: very rarely - violation of accommodation, blurredness, nystagm.
From the side of the hearing organs: the frequency is unknown - Vertigo.
From the side of the SCC: rarely - tachycardia.
From the digestive system: infrequently - diarrhea.
Hepatobiliary disorders: rarely - change of functional hepatic samples (increasing transaminase activity, alkaline phosphatase, Gamma-glovedransferase and bilirubin levels).
From the skin: infrequently - rash, itching; rarely - urticaria; Very rarely - angioedema swelling, persistent medicinal erythema.
From the urinary system: very rarely - Dizuriy, Enuresis; The frequency is unknown - urine delay.
General disorders: infrequent - asthenia, malaise; Rarely - peripheral edema.
Research: rarely - improving body weight.
Medicinal interaction
Based on the analysis of pharmacodynamics, Cetirizin pharmacokinetics interaction with other drugs is unlikely.
There was no significant interaction with pseudoephedrine or theophylline (at a dose of 400 mg / day) in special research of drug interaction.
The simultaneous use of cetirizin with ethanol and other drugs depressing the CNS can further reduce the concentration of attention and speed of reactions, although Cetirizin does not enhance the effect of ethanol (at its blood concentration of 0.5 g / l).
Dosage Cetirizin Sandoz
Pills
Children aged from 6 to 12 years old and with a mass of body less than 30 kg of 5 mg (1/2 tab.) In the evening; With a mass of body more than 30 kg - 10 mg (1 tab.) In the evening. Possible reception of 5 mg (1/2 tab.) 2 times / day (in the morning and evening).
Children aged 2 to 12 years old and with a mass of body less than 30 kg are prescribed 5 ml (1 dimensional spoon); With a mass of body more than 30 kg - 10 ml (2 dimensional spoons) in the evening. Possible receive 5 ml (1 dimensional spoon) 2 times / day (in the morning and evening).
Children aged 1-2 years are prescribed 2.5 mg (5 drops) 2 times / day; at the age of 2-6 years - 2.5 mg (5 drops) 2 times / day (in the morning and in the evening) or 5 mg (10 drops) in the evening; At the age of 6-12 years - 5 mg (10 drops) 2 times / day (in the morning and evening) or 10 mg (20 drops) in the evening.
Patients with renal failure should reduce the recommended dose by 2 times.
If the liver function is violated, the dose must be selected individually, especially careful - with simultaneous renal failure.
Elderly people with a normal kidney function of the dose adjustment is not required.
In seasonal allergic ritin, the duration of adult therapy is usually from 3 to 6 weeks, and with a short-term exposure of allergen, enough reception within 1 week. The duration of therapy for children over the age of 6 years is from 2 to 4 weeks, and with short-term exposure of allergen, enough reception within 1 week.
Tablets are taken inward, regardless of meals, not chewing and drinking with enough liquid, preferably in the evening.
Overdose
Symptoms (may be observed in a single reception of cetirizine at a dose of 50 mg): confusion, diarrhea, dizziness, increased fatigue, headache, malaise, mydriasis, itching, anxiety, weakness, sedative effect, drowsiness, stupor, tachycardia, tremor, urine delay.
Treatment: stomach wash or stimulation vomiting, appointment activated coal; Supporting and symptomatic therapy. No specific antidote. Hemodialysis is ineffective.
Precautions
In view of the potential depressing influence on the CNS, caution should be taken when appointing cetirizine in the form of droplets for receiving inside children up to 1 year with the following risk factors for the occurrence of sudden childhood syndrome, such as (but not limited to this list) APNEE syndrome in a dream or sudden children's syndrome Death of children breast-age Brother or sister; Mother abuse of drugs or smoking during pregnancy; young mother age (19 years and younger); abuse of smoking nanny caring for a child (one pack of cigarettes per day or more); Children who regularly fall asleep face down and whom did not fit on the back; premature (gestational age less than 37 weeks) or born with insufficient body weight (below the 10th percentage from gestational age) children; Joint admission of drugs that affect the depressing effect on the CNS.
In patients with damage to the spinal cord, prostatic hyperplasia, as well as in the presence of other predisposing factors to the urine delay required, caution is required, since Cetirizine can increase the risk of urine delay.
It is recommended to be careful when applying cetirizine simultaneously with ethanol, although therapeutic doses The clinically significant interaction with ethanol (at the concentration of ethanol in blood is 0.5 g / l). Care should be taken in patients with epilepsy and increased convulsive readiness.
Before appointing allergological samples, a three-day "wash" period is recommended due to the fact that the Blocators H1-histamine receptors inhibit the development of skin allergic reactions.
Impact on the ability to manage vehicles, mechanisms. With an objective assessment of the ability to drive vehicles and control mechanisms, any unwanted phenomena was significantly identified when applying cetirizine in the recommended dose. However, patients with dumplings on the background of receiving cetirizin it is advisable to refrain from driving a car, practicing potentially hazardous types of activities or management of mechanisms that require increased concentration and speed of psychomotor reactions.
Activity: Cetirizine;
1 tablet contains cetirizine dihydrochloride 10 mg
Auxiliary substances: lactose, microcrystalline cellulose, silicon colloidal dioxide, magnesium stearate, titanium dioxide (E 171), hyprontellos, macrogol 4000.
Dosage form"Type \u003d" Checkbox "\u003e
Dosage form
Tablets covered with film shell.
White oblong tablets covered with film shell, with notch on one side.
Pharmacological group
"Type \u003d" Checkbox "\u003e
Pharmacological group
Antihistamines for systemic use.
Cetirizin - Anti-Histamic agent II generation, selective and powerful blocker N 1 prolonged receptors. Cetirizine does not produce a significant anticholinergic and antiserotonin effect. In therapeutic doses, there is no sedative activity and does not cause drowsiness. Cetirizin affects the early histamine-dependent stage of allergic reactions and late cellular stageSuppresses the release of histamine, reduces the migration of inflammatory cells, such as eosinophils. Prevents the occurrence of bronchospasm induced by high concentrations of histamine.
Cetirizina Dihydrochloride is quickly absorbed from digestive tract. The maximum plasma concentration (0.3 μg / ml) is usually achieved 40-60 minutes after reception. Maximum therapeutic effect Developed after 4 - 8:00 and continues up to 24 hours. Approximately 93% of cetirizin binds to blood plasma proteins. The volume of the distribution of cetirizine is approximately 0.50 l / kg. The application at a dose of 10 mg does not lead to cumulation of cetirizin. Approximately 70% of the dose entered is highlighted by the kidneys mainly unchanged. In renal failure, the elimination of the drug slows down.
Indications
Symptomatic treatment allergic diseases: chronic (year-round) allergic rhinitis seasonal allergic rhinitis allergic conjunctivitis Itching of various types and urticaria, including chronic idiopathic urticaria, swelling quinque.
Contraindications
Increased sensitivity to cetirizin or other components of the drug. Heavy forms of nephropathy; Violation of the kidney function (Creatinine clearance<10 мл / мин).
Proper security measures when applying
The drug contains lactose, so it should not be prescribed to patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose maleabsorption syndrome.
Reception of cetirizine should be discontinued at least 72 hours before skin samples, since it is possible to obtain erroneous results.
As with the reception of antihistamine drugs, alcohol use should be avoided.
Application during pregnancy or breastfeeding
Since Cetirizine penetrates breast milk, it is not appointed to women who feed the breast.
The ability to influence the reaction rate when managing motor vehicles or other mechanisms
Before finding out the individual reaction to Cetirizin during treatment, care must be taken when managing vehicles and classes by other potentially hazardous activities that require increased concentrations of attention and speed of psychomotor reactions.
Children
Due to the lack of relevant data, appoint Cetirizin babies and children under 2 years old is not recommended; Aged 2 to 6 years, the drug is recommended to be used in another dosage form (solution).
Method of application and dose
It is used inside, regardless of meals, preferably in the evening.
Children over 12 years old and adults take 10 mg (1 tablet) per day.
For children from 2 to 12 years, the dose depends on body weight:
- when body weight is less than 30 kg - 5 mg (½ tablets) (aged 2 to 6 years old, the drug is recommended to be used in another dosage form)
- with the mass of the body more than 30 kg - 10 mg (1 tablet), in individual cases it is possible to divide into 2 separate doses (by ½ tablets in the morning and in the evening).
Patients with hepatic insufficiency are not required dose correction. Elderly patients may exhibit greater sensitivity to the drug, which requires a dose correction.
Patient with impaired kidney function.
The dosing interval should be adjusted individually, depending on the status of the kidney function. Dose should be adjusted in accordance with the table.
* For children with a body weight less than 30 kg - ½ tablets (5 mg), according to
The duration of the drug is determined by the doctor. Typically, the course of treatment is 7 days. With seasonal allergic rhine, the course of treatment can last 3 - 6 weeks (in children - 2 - 4 weeks). In chronic idiopathic urticaria and chronic allergic ritin, the available data indicate the possibility of treatment for up to 1 year. In the case of supporting the treatment of asthmatic states of allergic origin, the treatment time can be 6 months.
Overdose
With a significant overdose, drowsiness, tremor, tachycardia, urination delay, itching, skin rashes may occur.
In cases of overdose, standard measures should be applied to remove the drug and prevent its further absorption, in particular, washing the stomach. It should be observed for the further state of the patient. Specific antidote is unknown.
Cetirizin hydrochloride is not amenable to dialysis.
Side effects
From blood and lymphatic system: very rarely thrombocytopenia.
From the immune system: rarely increased sensitivity; Very rarely - anaphylactic shock.
Mental disorders: not common - arousal; Rarely - aggression, confusion, depression, hallucination, insomnia.
From the side of the nervous system: often - headache, drowsiness, insomnia are not common - paresthesia, dizziness is rare - convulsions, violation of coordination of movements; Very rare - fainting, change in taste, tremor.
Violation of vision: very rarely - violation of accommodation, fuzziness of vision, oculotor crises, especially in children.
Violations: rarely - tachycardia.
Disturbance GTS: often - dry mouth; Not common - pain in the abdomen, nausea, diarrhea, digestive disorder, gastritis.