Innovative methods of treatment - types of vaccines for diabetes. Vaccinations for children and juvenile diabetes (type I diabetes) Diabetes vaccine

The news is on everyone's lips: a vaccine for diabetes has already appeared, and soon it will be used to prevent a serious illness. A press conference was recently held, chaired by Salvador Chacón Ramirez, President of the Beating Diabetes Foundation, and Lucia Zarate Ortega, President of the Mexican Association for the Diagnosis and Treatment of Autoimmune Disorders.

At this meeting, a vaccine against diabetes is officially presented, which can not only prevent the disease, but also its complications in diabetics.

How does the vaccine work and is it really capable of defeating the disease? Or is it just another commercial deception? This article will help you understand these issues.

Features of the development of diabetes

As you know, diabetes is an autoimmune disease in which the functioning of the pancreas is impaired. With the development of type 1 pathology, the immune system adversely affects the beta cells of the islet apparatus.

As a result, they stop producing the sugar-lowering hormone that the body needs - insulin. This disease affects mainly the younger generation. During the treatment of type 1 diabetes, patients need to constantly inject the hormone, otherwise death will occur.

In type 2 diabetes, insulin production does not stop, but the target cells stop responding to it. Such a pathology develops when leading the wrong lifestyle in people over 40-45 years old. At the same time, for some, the likelihood of developing the disease is much higher. First of all, these are people with a hereditary predisposition and overweight. When treating type 2 diabetes, patients need to adhere to proper nutrition and active image. In addition, many have to take hypoglycemic medications to control their sugar levels.

It should be noted that the first and second types of diabetes cause various complications over time. With the progression of the disease, the pancreas is depleted, diabetic foot, retinopathy, neuropathy and other irreversible consequences develop.

When do you need to sound the alarm and contact your doctor for help? Diabetes is insidious disease and may be virtually asymptomatic. But still, you should pay attention to the following signs:

1. Constant thirst, dry mouth.
2. Frequent urination.
3. Unreasonable hunger.
4. Dizziness and headaches.
5. Tingling and numbness of the limbs.
6. Deterioration of the visual apparatus.
7. Rapid weight loss.
8. Poor sleep and fatigue.
9. Violation menstrual cycle among women.
10. Sexual problems.

In the near future it will be possible to avoid the development of "sweet ailment". The type 1 diabetes vaccine may be an alternative to conservative treatment with insulin therapy and hypoglycemic agents.

A new method of diabetes therapy

Sugar level

A new method of treatment diabetes mellitus Type 1, both in children and adults, is autohemotherapy. Studies of such a drug have proven that it does not have side effects... Scientists note that the patients who were vaccinated, over time, felt a significant improvement in health.

Mexico is the inventor country of this alternative technique. The essence of the procedure was explained by Doctor of Medicine Jorge Gonzalez Ramirez. Patients are sampled 5 cubic meters of blood. cm and mixed with saline (55 ml). Further, such a mixture is cooled to +5 degrees Celsius.

Then the diabetes vaccine is administered to the person, and over time, the metabolism is adjusted. The effect of vaccination is associated with the following processes in the patient's body. As you know, body temperature healthy person equal to 36.6-36.7 degrees. When the vaccine is administered at a temperature of 5 degrees, heat shock occurs in the human body. But this stressful condition has a beneficial effect on metabolism and genetic errors.

The vaccination course lasts 60 days. Moreover, it must be repeated every year. As the inventor notes, the vaccine can prevent the development of serious consequences: stroke, renal failure, blindness and other things.

However, the introduction of a vaccine cannot give a 100% guarantee of cure. It is a cure, but not a miracle. The patient's life and health remains in his hands. He must strictly follow the recommendations of a specialist and be vaccinated annually. And, of course, nobody canceled the special diet either.

Medical research results

Every 5 seconds on the planet, one person develops diabetes, and every 7 seconds, someone dies. In the United States alone, type 1 diabetes affects about 1.25 million people. The statistics, as we can see, are completely disappointing.

Many modern researchers claim that one very familiar vaccine will help to overcome the disease. It has been used for over 100 years, it is BCG - a vaccine against tuberculosis (BCG, Bacillus Calmette). By 2017, it was also being used in the treatment of bladder cancer.

When the immune system attacks the pancreas, pathogenic T cells begin to be produced. It is they that negatively affect the beta cells of the islets of Langerhans, preventing the production of the hormone.

The results of the study were overwhelming. The participants in the experiment were injected twice in 30 days with the vaccine against tuberculosis. Summing up the results, the researchers found no T cells in patients, and in some diabetics with type 1 disease, the pancreas began to produce the hormone again.

Dr. Faustman, who organized these studies, wants to conduct experiments with patients who have a long history of diabetes. The researcher wants to achieve lasting therapeutic results and improve the vaccine to become a valid cure for diabetes.

The new study will be conducted in people between the ages of 18 and 60. They are going to be given the vaccine twice a month and then shorten the procedure to once a year for 4 years.

In addition, this vaccine has been used in childhood from 5 to 18 years old. Research has proven that it can be used in such age category... No adverse reactions was not identified, and the frequency of remission did not increase.

Prevention of diabetes

While vaccination has not become widespread, moreover, further research is being carried out.

Many diabetics and people at risk have to follow conservative preventive measures.

However, such activities will also help reduce the likelihood of developing the disease and its complications. The main principle is to keep healthy and diet.

A person needs:

• follow a special diet that includes complex carbohydrates and foods high in fiber;
• engage in physiotherapy exercises at least three times a week;
• get rid of extra pounds;
• regularly monitor the level of glycemia;
• get enough sleep, establish a balance between rest and work;
• avoid strong emotional stress;
• avoid depression.

As you can see, modern medicine is looking for new ways to combat the disease. Perhaps very soon the researchers will announce the invention of a universal vaccine for diabetes mellitus. In the meantime, you have to be content conservative methods treatment.

The video in this article explains the new diabetes vaccine.

A group of American and Dutch scientists have developed a genetically engineered "reverse action vaccine" intended for the treatment of type 1 diabetes (insulin-dependent), and successfully carried out the first phase of its clinical trials. Unlike conventional vaccines, BHT-3021 does not activate, but suppresses the patient's immune system, thereby restoring the normal biosynthesis of insulin. The work was published in the journal Science Translational Medicine.

At the heart of the pathogenesis of type 1 diabetes is the lack of insulin production by the beta cells of the islets of Langerhans of the pancreas, caused by their destruction under the influence of the autoimmune process. The main target of the attack from immune killer cells - CD8-positive T-lymphocytes - is proinsulin, the precursor of insulin.

In order to reduce the overactivity of the immune system and protect beta cells, the authors, specialists from Stanford (USA) and Leiden (Netherlands) Universities, developed using genetic engineering methods BHT-3021 vaccine, which is a circular DNA molecule (plasmids) that plays the role of the vector for the delivery of the proinsulin genetic code. Once it enters the tissues and biological fluids of the body, BHT-3021 "takes a hit" - it distracts the attention of killer cells, thus generally reducing their activity, while not affecting the rest of the immune system. As a result, beta cells restore their ability to synthesize insulin.

The first phase of clinical trials of BHT-3021, previously proven to be effective in an animal model, involved 80 patients over 18 years of age who had been diagnosed with type 1 diabetes in the last five years. Half of them received weekly intramuscular injections BHT-3021 and the other half is placebo.

After this period, the group receiving the vaccine showed an increase in the level of C-peptides in the blood, a biomarker indicating the restoration of beta-cell function. No serious side effects were reported for any of the participants.

The BHT-3021 is still far from commercial use. It was licensed to California-based biotechnology company Tolerion, which intends to continue clinical trials of the vaccine in a wider range of patients. It is assumed that 200 young people diagnosed with insulin-dependent diabetes will take part in them. Scientists want to test whether BHT-3021 can slow or stop the disease at an early stage.

Type 1 diabetes is believed to affect about 17 million people worldwide. Most often, it affects young people - children, adolescents and adults under 30 years of age.

Syringes will be a thing of the past - new DNA vaccine has been successfully tested in humans

Thanks to the development of a new method of treatment, people who suffer from type 1 diabetes will soon be able to forget about syringes and constant injections of insulin. Currently, Dr. Laurence Steinman of Stanford University reported that new method treatment of type 1 diabetes mellitus has been successfully tested in humans and may find widespread use in the treatment of this disease in the foreseeable future.

Lawrence Steinman, M.D./Stanford University

The so-called "reverse vaccine" works by suppressing the immune system at the DNA level, which in turn stimulates the production of insulin. The Stanford University development could be the first DNA vaccine in the world that can be used to treat humans.

“This vaccine takes a completely different approach. It blocks a specific response from the immune system, rather than creating specific immune responses like conventional flu or polio vaccines, ”says Lawrence Steinman.

The vaccine was tested on a group of 80 volunteers. The studies were carried out over two years and showed that in patients who received treatment according to the new method, there was a decrease in the activity of cells that destroy insulin in the immune system. At the same time, no side effects were recorded after taking the vaccine.

As the name implies, a therapeutic vaccine is not intended to prevent a disease, but to treat an existing disease.

Scientists, having determined which types of leukocytes, the main "warriors" of the immune system, attack the pancreas, have created a drug that reduces the number of these cells in the blood without affecting other components of the immune system.

Participants in the trials received injections of the new vaccine once a week for 3 months. In parallel, they continued to receive insulin.

In the control group, patients received a placebo instead of a vaccine against the background of insulin injections.

The creators of the vaccine report that in the experimental group that received new drug, there was a significant improvement in the work of beta cells, which gradually restored the ability to produce insulin.

“We are close to making the dream of any immunologist come true: we have learned to selectively“ turn off ”the defective component of the immune system without affecting its work as a whole,” says one of the co-authors of this discovery, Professor Lawrence Steinman.

Type 1 diabetes is considered a more severe disease than its “cousin” type 2 diabetes.

The word diabetes itself is a derivative of the Greek word "diabaino", which means "I go through something, through", "I flow." The ancient physician Aretheus of Cappadocia (30 ... 90 AD) observed polyuria in patients, which he associated with the fact that fluids entering the body flow through it and are excreted unchanged. In 1600 A.D. e. to the word diabetes mellitus was added (from Latin mel - honey) to denote diabetes with a sweet taste of urine - diabetes mellitus.

The syndrome of diabetes insipidus was known in ancient times, but until the 17th century, the differences between diabetes insipidus and diabetes insipidus were not known. In the XIX - early XX centuries, detailed works on diabetes insipidus appeared, the connection between the syndrome and the pathology of the central nervous system and the posterior lobe of the pituitary gland. IN clinical descriptions the term "diabetes" often means thirst and diabetes (sugar and diabetes insipidus), however, there is also "passing through" - phosphate-diabetes, renal diabetes (due to a low threshold for glucose, not accompanied by diabetes), and so on.

Type 1 diabetes mellitus itself - a disease whose main diagnostic feature is chronic hyperglycemia - elevated level blood sugar, polyuria, as a result of this - thirst; weight loss; excessive appetite, or lack thereof; bad state of health... Diabetes mellitus occurs when various diseasesleading to a decrease in the synthesis and secretion of insulin. The role of the hereditary factor is being investigated.

Type 1 diabetes can develop at any age, but young people (children, adolescents, adults under 30) are most likely to develop the disease. The pathogenetic mechanism of type 1 diabetes is based on insufficient insulin production. endocrine cells (β-cells of the islets of Langerhans of the pancreas), caused by their destruction under the influence of certain pathogenic factors ( viral infection, stress, autoimmune diseases and others).

Type 1 diabetes accounts for 10-15% of all cases of diabetes, more often develops in childhood or adolescence. The main method of treatment is insulin injections, which normalize the patient's metabolism. Left untreated, type 1 diabetes progresses rapidly and leads to severe complications such as ketoacidosis and diabetic coma, which end in death.

Sources: health-ua.org, hi-news.ru and wikipedia.org.

The high prevalence and high mortality rate forcing scientists around the world to develop new approaches and concepts in the treatment of the disease.

It will be interesting for many to learn about innovative methods of treatment, the invention of a vaccine against diabetes, about the results of world discoveries in this area.

Diabetes mellitus treatment

The results in the treatment, achieved by using traditional methods, appear after a long period of time. Modern medicinetrying to reduce the achievement of positive dynamics of treatment, develops more and more new drugs, using innovative approaches, gets better and better results.

In the treatment of type 2 diabetes, 3 groups of drugs are used:

• (2nd generation).

The action of these drugs is aimed at:

• decreased glucose absorption;
• suppression of glucose production by liver cells;
• stimulation of insulin secretion by acting on pancreatic cells;
• blockage of cells and tissues of the body;
• increased insulin sensitivity of fat and muscle cells.

Many drugs have disadvantages in their effect on the body:

• weight gain;
• itchy skin;
• disruption of the digestive system.

The most effective and reliable is considered. It is flexible in application. You can increase the dose, combine with others. When administered together with insulin, it is permissible to vary the dosage, reducing it.

The most proven method of treatment for type 1 and 2 diabetes has been and is insulin therapy.

Research here, too, does not stand still. With the help of advances in genetic engineering, modified short and long acting insulins are obtained.

The most popular are insulin short acting and - long-term.

Their joint use duplicates as closely as possible the normal physiological secretion of insulin produced by the pancreas and prevents possible complications.

A breakthrough in the treatment of type 2 diabetes mellitus was the practical experience of Dr. Shmuel Levita in the Israeli clinic "Assut". At the heart of his development is the gravicentric concept, which changes traditional approaches, bringing the change in patient habits to the fore.

The computer blood monitoring system created by Sh. Levit monitors the work of the pancreas. The prescription list is drawn up after decrypting the data of the electronic chip, which the patient wears on himself for 5 days.

To maintain a stable state in the treatment of patients with type 1 diabetes, he also developed an apparatus that is attached to the belt.

It constantly detects blood sugar and, with the help of a special, injects an automatically calculated dose of insulin.

New therapy methods

Some of the most innovative diabetes treatments include:

• use of stem cells;
• vaccination;
• cascade blood filtration;
• transplantation of the pancreas or parts of it.

The use of stem cells is an ultra-modern method. It is carried out in specialized clinics, for example, in Germany.

In the laboratory, stem cells are grown, which are implanted into the patient. New blood vessels and tissues are formed, functions are restored, glucose levels are normalized.

Vaccination was encouraging. For almost half a century, scientists in Europe and America have been working on the creation of a vaccine for diabetes mellitus.

The mechanism of autoimmune processes in diabetes mellitus is reduced to destruction by T-lymphocytes.

The vaccine, created using nanotechnology, should preserve the beta cells of the pancreas, restore damaged areas and strengthen the necessary remaining T-lymphocytes, since without them the body will remain vulnerable to infections and oncology.

Cascade blood filtration or extracorporeal hemocorrection is used for severe complications sugar disease.

The blood is pumped through special filters, enriched with the necessary medicines and vitamins. She is modified, freed from toxic substancesthat negatively affected the vessels from the inside.

In the world's leading clinics, transplantation of an organ or its parts is used in the most hopeless cases with severe complications. The outcome depends on a well-chosen anti-rejection agent.

Video about diabetes from Dr. Komarovsky:

Medical research results

According to data for 2013, Dutch and American scientists have developed the BHT-3021 vaccine against type 1 diabetes.

The action of the vaccine is to replace the beta cells of the pancreas, substituting themselves for the destruction of the immune system by T-lymphocytes.

The saved beta cells can start producing insulin again.

Scientists have called this vaccine "reverse-acting vaccine" or reverse. It suppresses the immune system (T-lymphocytes), restores the secretion of insulin (beta cells). Usually, all vaccines strengthen the immune system - direct action.

Dr. Laurence Steiman of Stanford University called the resulting vaccine "the first DNA vaccine in the world" because it does not create a specific immune response, like a conventional flu vaccine. It reduces the activity of immune cells that destroy insulin without affecting its other links.

The property of the vaccine was tested on 80 volunteer participants.

Research has shown positive results. None side effects have not been identified. All subjects had an increased level of C-peptides, which indicates the restoration of the pancreas.

Insulin and C-peptide formation

To continue the trials, the vaccine license was transferred to the biotechnology company Tolerion in California.

In 2016, the world learned about a new sensation. At the conference, President of the Mexican Association for Diagnosis and Treatment autoimmune diseases Lucia Zarate Ortega and President of the Victory over Diabetes Foundation, Salvador Chacon Ramirez, presented a new vaccine against type 1 and 2 diabetes.

The algorithm for the vaccination procedure is as follows:

1. 5 blood cubes are drawn from the patient's vein.
2. 55 ml of a special liquid mixed with saline is added to a test tube with blood.
3. The resulting mixture is sent to the refrigerator and kept there until the mixture has cooled to 5 degrees Celsius.
4. Then it is heated to a human body temperature of 37 degrees.

As temperatures change, the composition of the mixture changes rapidly. The resulting new composition will be the required Mexican vaccine. You can store this vaccine for 2 months. Treatment with it along with special diets and physical exercise lasts a year.

Before treatment, patients are offered right there, in Mexico, to undergo a full examination.

The achievements of Mexican studies have been internationally certified. This means that the Mexican vaccine has received a "start in life."

Relevance of prevention

Since innovative methods of treatment are not available to everyone suffering from diabetes, the prevention of the disease remains an urgent issue, because type 2 diabetes is exactly the disease, the ability not to get sick of which mainly depends on the person himself.

Proper nutrition is paramount in prevention.

It is necessary to limit sweet, starchy, highly fatty foods. Eliminate alcohol, soda, fast food, fast and questionable food, which includes harmful substances, preservatives.

Increase fiber-rich plant foods:

• vegetables;
• fruits;
• berries.

Drink purified water up to 2 liters during the day.

Disability, exhaustion of the body - the consequences of diabetes. The immune system oppressed, as a result of which a person is highly susceptible to the influence of viruses and various diseases. Modern medicine solves this problem by vaccinating diabetics. The mandatory program for the use of vaccines for a group of patients with type 1 and 2 diabetes includes monitoring and supervision by the attending physician, mandatory adherence to dietary recommendations and healthy way life.

From the flu virus

For diabetes, it is recommended to get a flu vaccine every season. Deaths from influenza in this category of patients are numerous. This vaccination is also indicated for pregnant women. The best time to get the flu vaccine is mid-fall: October - November. Patients with influenza should not stop taking drugs prescribed by their endocrinologist.

For pneumococcal infection

With diabetes mellitus, doctors strongly advise getting vaccinated against pneumococcal infection... Special attention should be paid to the reaction after vaccination in diabetics over 65 years of age. Sinusitis, pneumonia and meningitis are some of the side diseases in this group of patients that can occur as a result of pneumococcal infection.

From hepatitis B

People with signs of type 1 and type 2 diabetes are shown to be vaccinated against hepatitis B. The weakening of the effect of this vaccine was recorded in 2 cases: in people over 60 years old. This vaccination can be done at the discretion of the attending physician and the patient himself. This is due to the low rate of vaccine exposure at that age. The obese population also has problems.

More than 50% of patients with this disease have weight problems. The thick layer of fat prevents the vaccine needle from working properly on the muscle.

Diabetes and the relationship with some childhood vaccines

Pertussis vaccine

The body's response to vaccination is to increase the production of insulin with the subsequent depletion of the pancreas, that is, the islets of Langrens, which synthesize this hormone. The consequence can be 2 diseases: hypoglycemia and diabetes. Complications after this vaccination can lead to low rate glucose in the child's blood. This vaccine contains pertussis toxin. Refers to poisonous substances. May affect the body in unpredictable ways. Therefore, the doctors decided to check the connection between the pertussis vaccine and diabetes.

Rubella, mumps and measles vaccine

MMR is one of the medical names. The components contained, namely rubella, affect children's organism like a true disease. Mumps and rubella are known to cause type 1 diabetes. If a child is infected in the womb, which has had rubella during gestation, later, after the rubella vaccination, diabetes may develop due to the interaction of a weakened virus with what is already present in the child's body. Since the pancreas is the target organ of the carcinogenic agent, the likelihood of developing sugar disease is high.

The mumps component (mumps), like a true virus, is capable of affecting the pancreas and provoking pancreatitis. With a weakened state of the organ, the risk of developing diabetes mellitus remains for high level... In this case, pig antibodies negatively affect the beta cells of the pancreas, attacking them.