Instruction

Oxep is a combined drug. Refers to a large group of penicillins. It is used in the treatment of many infectious diseases of different organs and systems.

Forms of release and composition

This medical preparation is considered combined because it combines 2 active substances: ampicillin and oxacillin. Both compounds relate to penicillins, which contributes to the expansion of the bactericidal action of the drug.

The drug is produced in 2 main forms: capsules and powder for the preparation of an injection solution.

Capsules are designed only for intake. Each of them is exactly 125 mg of active substances. They are packed in special blisters for 10 pcs. In each or in polymer cans of 20 pcs.

Oxampa-sodium powder is intended for the preparation of an injection solution. The solution is entered both injectable and infusion method. The powder is placed in special glass bottles, in which there is 0.5 g of the combination of active substances.

This is an antibiotic or not

The drug refers to the antibiotics of the penicillin row. Has an extensive spectrum of action.

pharmachologic effect

The antibiotic combines the action of ampicillin and oxacillin.

Ampicillin is a semi-synthetic Penicillin derivative. Not destroyed under the influence of strong acids and has an excellent bactericidal effect. There is an activity both in relation to gram-positive and gram-negative pathogenic bacteria.

Oxacillin is evaluated not only to acids, but also to penicillinase. Bactericidal action applies to almost all groups of harmful microorganisms.

Pharmacokinetics

Almost the entire dose of the medical preparation after taking inside falls directly into the bloodstream. The largest concentration of active compounds is observed 2 hours after taking medication.

The elimination occurs by renal filtering. Almost all the dose comes out with urine, only a small amount - with bile.

The drug does not accumulate in the body even with long use.

Indications for use

The antibiotic is prescribed mainly for comprehensive treatment infectious diseases inflammatory character. This is especially true of diseases that were caused by pathogenic bacteria, sensitive to the active components of the medication.

Main indications for use:

• skin and soft tissue infections: Ryg, impetigo, dermatosis;
• cholegit and cholecystitis;
• sinusitis, otitis the middle ear, tonsillitis;
• pyelonephritis, cystitis, cervicitis and urethritis;
• gonorrhea;
• bronchitis, pneumonia.

The medicine is often used to prevent the development of secondary infection after the surgical interventions carried out.

Contraindications

There are some prohibitions for the use of a medical process:

• individual intolerance to the components of the medication;
• infectious mononucleosis;
• lympholoicosis;
• children's age up to 3 years;
• the period of tooling the child and breastfeeding.

All these contraindications need to be taken into account before the start of treatment. The patient must be aware of all risks and possible adverse reactions.

OKSAMPA use and dosage method

The tool is adopted both in capsuated form and in the form of injections. Take medicine regardless of food, but it is better that after receiving food until the medication has passed at least 2 hours.

With pyelonephritis

With pyelonephritis, adults are prescribed 2 g of antibiotic. Daily dose must be divided into 4 receptions.

Little children show injections, since the effect of the capsule may not give a positive result. The solution is introduced both intravenously and intramuscularly. Break powder in water for injection. So that the injections were not so painful, novocaine can be added.

With cystitis

When cystitis, the dosage for adults sometimes increase to 4 g. This is necessary for better destruction of pathogenic bacteria. But if there is no positive result, you need to replace the medical process with another.

For urethritis

When uretrite, the maximum daily dose can be up to 8 g. It is divided into 4 receptions. The effect of the use of medication should be achieved in about 5 days. In severe cases, additional antibacterial therapy is prescribed, which enhances the action of Oxampa.

How to give children

Children medication is prescribed mainly in capsuated form. Daily dose for children 7-14 years - 50 mg per kg of body weight; 3-7 years - 100 mg per kg of weight. Daily dose is divided into several techniques. Course treatment - from 5 to 14 days.

Do Oxamp causes side effects

Upon reception, unwanted side effects often arise:

• nausea, vomiting, diarrhea;
• dysbacteriosis, change in taste, enterocolitis;
• leukopenia and anemia;
• rises the risk of internal bleeding;
• urticaria, the development of anaphylactic shock and swelling swelling;
• rhinitis, conjunctivitis, arthralgia;
• superinfection.

All these negative reactions should take place without special medical intervention immediately after the cancellation of the medication. But if this does not happen, you may need disintellation and antiallergic therapy.

Overdose

Overdose drug is not marked. But in some cases, its symptoms can be determined to increase the severity of some side effects. If the patient's well-being deteriorates, the stomach is washed, sorbents are prescribed. In the presence of any complications, the symptomatic therapy is carried out.

Features of the use of the drug Oxep

Antibacterial treatment should be changed in the case of superinfection.

If the reactions of hypersensitivity to penicillins are observed, the risk of developing cross-allergic reactions increases.

If anaphylactic shock develops, it is necessary to take urgent measures to stop it. Patient introduces epinephrine, antihistamine medical preparations and glucocorticosteroids.

During pregnancy and lactation

Because active substances penetrate the protective barrier of the placenta, the medication cannot be taken during the baby tool. The existing compounds have teratogenic and mutagenic effect on the fruit. The appearance of certain anomalies of the intrauterine development of the fetus.

The active components of the medicine penetrate and breast milk. Therefore, for the period of treatment it is better to abandon breastfeeding.

In childhood

In the treatment of bacterial infections, the tool is forbidden to give children up to 3 years. After a three-year-old, treatment is carried out strictly according to the instructions with clear observance of the dosage.

With violations of the kidney function

In the case of a history of renal failure, it is possible to increase the toxic effects of the drug to the central nervous system.

When violations of the liver function

With a long-term course of treatment, it is necessary to monitor the liver function. With the deterioration of hepatic samples, the dosage is reduced to the minimum efficient or completely cancel the reception of the drug.

Influence on the concentration of attention

The antibiotic affects the speed of psychomotor reactions and the concentration of attention. Therefore, it is better to avoid self-control vehicle Or work with complex mechanisms.

Medicinal interaction

In the treatment of infectious diseases, a whole range of medicines is often used. Some combinations contribute to the fastest recovery. Others are considered to be antagonists each other.

With other drugs

Glucosamine, aminoglycosides and some laxatives reduce the absorption of the medical process. Cephalosporins and rifampicin improve the effect of the antibiotic. Tetracycles, macrolides and sulfonamides are antagonists of Oxampa. When sharing an activity increases indirect anticoagulantov, the activity of intestinal microflora and synthesis of vitamin K.

Ascorbic acid helps to increase the absorption of the drug. The effectiveness of many oral contraceptives is reduced. Diuretics and nonsteroidal anti-inflammatory drugs increase the concentration of Oxampa in the blood.

Compatible with alcohol

You can not apply with alcohol. The action on the CNS increases, the symptoms of intoxication becomes more pronounced. In this case, the effectiveness of the antibiotic itself is greatly reduced.

Terms and Storage Terms

Keep the medicine is needed at room temperature in a dry place. Protect maximally from direct sunlight and children.

Shelf life - 2 years from the date of manufacture, which must be defined on the original packaging.

Conditions of vacation from pharmacies

Medication can be bought at the prescription pharmacy.

Whether they sell without a recipe

The drug can be purchased only by a special recipe issued by the attending physician.

How much is

The cost of the capsules does not exceed 100 rubles. for packaging. Powder bottles are about 150 rubles.

Manufacturer

OJSC Synthesis (Russia).

Analogs

There are several analogs of the drug:

They all differ in price; They have different manufacturers. In its composition, these medicines are similar, have almost the same therapeutic effect on the body

Oxep is one of the combined antibiotics. Do the kids assign him as he acts on children's organism And which dosage is used?

Release form and composition

Oxepa is made in the form of capsules white color, Packed in blisters or jars of 10 or 20 pieces.

The effect of the drug is provided at once two antibacterial substances - oxacillin (in the form of sodium salt) and ampicillin (in the form of trihydrate). They are presented in each capsule in a 1: 1 ratio (dosage of each - 125 mg).

In addition, an injection form is produced, which is called Oxep-sodium. Such a drug is made in bottles containing a white-yellow porous or powder mass. In its composition - sodium salt of ampicillin, supplemented by sodium salt of oxacillin (the ratio of such ingredients - 2: 1).

A 10 ml bottle contains 200 mg of active substances, and the dosage of antibiotics in 20 ml bottles is 500 mg.

Such vials can be bought both one by one and in the package of 2, 5, 10 or 50 pieces.

Operating principle

Oxampa has an antibacterial effect, and due to the combination of two compounds at once, the spectrum of the bactericidal action of this medication is very extensive. The medicine destroys Schigella, hemophilic sticks, streptococci, salmonella, staphylococci, meningococci, treponam, actinomycetes and many other pathogens.

However, its action does not apply to pseudomonads and many strains of the protest.

Indications

The drug is prescribed with infections that are caused by the bacteria sensitive to Oxampa. Medication is in demand with bronchitis, tonsillitis, cholecystitis, urethritis, wound infection, dysentery, pleurite, angina, burns, pyelonephritis and many other pathologies.

It can also be prescribed for prevention, for example, surgical treatment Or with the danger of pneumonia in newborns.

From what age are prescribed?

Injection shape Medicines are used in the treatment of children of any age, including newborns.

Capsules are used in children over three years.

Contraindications

Oxep is not prescribed with hypersensitivity to its components, as well as with allergies on any beta-lactam antibiotics. In addition, such a medicine does not give children with lympholoicosis or infectious mononucleosis.

Side effects

The use of Oxampa can provoke an allergic reaction in a child, for example, in the form of conjunctivitis, quinque swelling, skin rash or even anaphylactic shock. In some patients, dysbacteriosis develops due to the use of this antibiotic, vomiting appears, the taste changes, the number of blood cells decreases.

If the medicine is appointed intramuscularly, then frequent by-effect It is painful in the place of the injection, and when administered to Vienna, perifelbitis or phlebitis can develop.

Instructions for use

To determine required child The amount of drug in capsules, you should know the weight of the patient. To calculate the dose, the body weight in kilograms is multiplied by 100, if the child is 3-7 years old, or 50, if its age is 7-14 years old. The resulting number is the daily dosage of Oxampa in milligrams (both antibiotics are taken into account), which is divided by 4-6 receptions.

For a teenager, over 14 years old, a one-time dose is 2-4 capsules, and on a day there are 8-16 capsules to patients.

To determine the dosage of Ukolov, Oxap-sodium, also need to take into account the weight and age of the child. If the medication is appointed a newborn baby, premature baby or infant to a year, then it takes from 100 to 200 mg per 1 kg of weight.

Children over a year to 7 years of age for calculating the dose are multiplied by weight per kg per 100 mg, and for children 7-14 years old - by 50 mg. Next, this daily dosage is divided into 3-4 injections, which can be both intravenous (and inkjet, and drip) and intramuscular.

Kick Oxep-sodium follows from the interval of 6-8 hours. If the course of the disease is severe, the doctor can increase the daily dose of 1.5-2 times. If a child over 14 years old, then the one-time dose of injecting Oxampa is the same as for adults - from 0.5 to 1 g (such a patient should receive 2-4 g of active substances).

For injection in the muscle, the contents of the vial should be brewed with sterile water (taking 2 ml for 0.2 g and 5 ml for 0.5 g of medication), but some doctors for anesthesia are prescribed novocaine breeding.

For intravenous injections, the powder is dissolved either by water for injections or isotonic solution in a volume of 10-15 ml.

If the medication is appointed child intravenous, then such injections are made only 5-7 days, and then go to intramuscular injections (If a longer course of therapy is required).

Overdose and Medicinal Interactions

Oxamp overdose cases were not registered. As for incompatibility with other drugs, the simultaneous reception of laxatives, antacids or glucosamine will interfere with Oxampa absorption, and the use of ascorbic acid, on the contrary, accelerate suction. Treatment should not be combined with such an antibiotic with the reception of diuretics, allopurinol, indirect anticoagulants or NSAIDs.

It is contraindicated to assign oxep and together with bacteriostatic antimicrobial means, for example, with sulfonamides, macrolides or tetracycles, since they are antagonists. But drugs with bactericidal action, on the contrary, enhance the effect of treatment with oxampom.

Such an action is noted in cephalosporins, vancomycin, aminoglycosides and rifampicin.

Terms for sale and storage

Oxepa refers to prescription products, so the doctor's advice is required before purchasing it.

The shelf life of the medicine is 2 years. While he has expired, the medication should be kept in hidden from high humidity and sunlight place.

The optimal storage temperature is below +20 degrees.

Dissolved in water for injection or glucose oxep-sodium cannot be stored. Such a solution is used immediately after breeding.

Instruction

by medical application

drug

Oxep ® -Natriya

Tradename

Oxep ® -Natriya

International non-proprietary title

Dosage form

Powder for the preparation of the injection solution 0.5 g

Composition for one bottle

active substances -ampicillin sodium (in terms of ampicillin) - 0.3335 g,

oxacillin sodium (in terms of oxacillin) - 0.1665 g

Description

White powder with yellowish colors

Pharmacotherapeutic group

Antibacterial drugs for system use. Beta-lactam antibacterial drugs. Penicillins in combination with beta lactamase inhibitors. Combination of penicillins.

Code ATX J01Cr50

Pharmacological properties

Pharmacokinetics

Time to achieve maximum concentration (TC MAX) after intramuscular administration Both blood antibiotics - 0.5-1 hours. The half-life period is 1-2 hours. The drug penetrates well into different organs and fabrics. For intravenous administration In the blood, the concentrations of the drug are created in the blood (after 5-10 minutes) in excess of those intramuscular administration. Both antibiotics are removed by the kidneys, partly with bile. For repeated administration Do not cumulate.

Pharmacodynamics

Oxep ® -Tatry - a combined antibiotic, which combines ampicillin and oxacillin action spectrum.

Ampicillin is a semi-synthetic penicillin, a bactericidal, acid resistant. Active against gram-positive neobrazuyuschih penicillinase (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae) and Gram (Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Salmonella spp., Shigella spp., Proteus mirabilis, Haemophilus influenzae) microorganisms. Oxacillin is a penicillinase-resistant semi-synthetic antibiotic from a group of penicillins, acid resistant; has a bactericidal action against Gram-positive microorganisms (Staphylococcus spp., Streptococcus spp., including Streptococcus pneumoniae, Bacillus anthracis, Corynebacterium diphtheriae, anaerobic spore-forming rods, including Clostridium), Gram negative cocci (Neisseria gonorrhoeae, Neisseria meningitidis ), Escherichia coli, Proteus Mirabilis, Haemophilus Influenzae, Klebsiella Pneumoniae, Actinomyces SPP., Treponema SPP.

To the action of the drug is resistant Pseudomonas Aeruginosa, and others. Nefering gram-negative bacteria Most strains of Proteus Vulgaris, Providencia Rettgeri, Morganella Morganii.

Indications for use

Bacterial infections caused by sensitive pathogens: sinusitis, tonsillitis, middle Otitis, bronchitis, pneumonia; Halgitis, cholecystitis, pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, cervicitis, dog, impetigo, secondary infected dermatoses and others

Prevention postoperative complications for surgical interventions (including on the background of immunodeficiency), infections in newborns (infection of the airbag fluid; breach of the newborn breathing, requiring the use of resuscitation measures; the risk of aspiration pneumonia)

Sepsis, endocarditis, meningitis, postpartum infection

Mode of application and doses

Intramuscularly and intravenously (inkjano or drip).

The doses of the drug referred to below are the sum of the dosages of ampicillin and oxacillin (sodium salts) in their fixed ratio 2: 1 (i.e., in the following dosages 0.5 g of the drug is equal to the amount of 333.5 mg of ampicillin + 166.5 mg oxacillin ).

Daily dose for adults and children over 14 years old - 3-6 g; For newborns, premature and children up to 1 year - 100-200 mg / kg / day; 1-6 years - 100 mg / kg / day; 7-14 years old - 50 mg / kg / day. The daily dose is introduced in 3-4 receptions with an interval of 6-8 hours. If necessary, the specified doses can be increased by 1.5-2 times. Maximum daily dose for adults - 8 g.

The duration of treatment depends on the severity of the disease (from 5-7 days to 10 days, and in chronic processes within a few months).

For intramuscular administration, the contents of the vial of 333,5 mg + 166.5 mg are dissolved in 5 ml of water for injection.

For intravenous jet administration (for 2-3 minutes), a one-time dose is dissolved in 10-15 ml of water for injection or 0.9% sodium chloride solution.

For intravenous drip administration An adult dose is dissolved in 100-200 ml of 0.9% sodium solution of chloride or 5% declaration solution (glucose) and administered at a speed of 60-80 CAP / min; Children as a solvent use 30-100 ml of 5-10% declaration solution (glucose). Intravenously introduced 5-7 days, followed by the transition to intramuscular administration.

The solution is used immediately after cooking.

Side effects

Often

Pain in the place of administration

Itching and skin peeling

Sometimes

Dysbacteriosis, change in taste, vomiting, nausea, diarrhea, moderate increase in the activity of "liver" transaminase

Headache

Harridge, conjunctivitis, rhinitis, skin hyperemia, angioedema edema

Seldom

Pseudommbranous enterocolit

Leukopenia, neutropenia, anemia, hematuria, proteinuria

Fever, arthralgia, eosinophilia, erythematous and maculopapulous rash, exfoliative dermatitis, multiform exudative erythema (incl. Stevens-Johnson syndrome), reactions similar to serum disease

Rarely

Anaphylactic shock

Flebit and perifelbitis (with intravenous administration), with intramuscular - at the injection site infiltrate

Causes

- others: seldom - Interstitial nephritis, nephropathy, superinfection (especially in patients with chronic diseases or reduced organism resistance), vaginal candidiasis

Contraindications

Hypersensitivity to preparations of the penicillin group and other beta-lactam antibiotics

Infectious mononucleosis, lymphole

Heavy liver disorders

Pregnancy and lactation period

Diseases of the gastrointestinal tract in history (colitis due to the use of antibiotics)

Medicinal interactions

Ampicillin. Pharmaceutically incompatible with aminoglycosides.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) have a synergistic effect; Bacteriostatic preparations (macrolides, chloramphenicol, lincoosamides, tetracycles, sulfonamides) - antagonistic effect.

Increases the efficiency of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); Reduces the effectiveness of estrogen-containing oral contraceptives, drugs, in the process of metabolism of which para-aminobenzoic acid is formed, ethinyl estradiol (in the latter case, the risk of developing bleeding "breakthrough" increases).

Diuretics, Allopurinol, Oxyphenbutayon, Phenylbutazone, Nonteroidal anti-inflammatory drugs and other drugs that block the channel secretion increase the concentration of ampicillin in the plasma (by reducing the channel secretion).

Allopurin increases the risk of skin rash.

Reduces clearance and increases the toxicity of methotrexate.

Oxacillin. Increases the toxicity of methotrexate (competition for the canal secretion); It may be necessary to increase the doses of calcium folinate (antagonist anti-pin folic acid) and longer use.

It is necessary to avoid co-use with other drugs that have a hepatotoxic effect.

It is not recommended to be prescribed simultaneously with bacteriostatic antibiotics (reducing efficiency).

Medicinal productsblocking the channel secretion increase the concentration of oxacillin in the blood.

special instructions

Carefully:children who are born in mothers with hypersensitivity to penicillins. Allergic reactions in history and / or bronchial asthma, renal failure, bleeding in history, enterocolit on the background of the use of antibiotics (a history).

In case treatment, it is necessary to monitor the condition of the function of the blood formation organs, liver and kidneys.

When signs of anaphylactic shock appear, urgent measures should be taken to remove the patient from this state: the introduction of epinephrine (adrenaline), glucocorticosteroids (hydrocortisone or prednisone) and antihistamine, if necessary, performed artificial ventilation of the lungs.

The possibility of the development of superinfection (due to the growth of microflora insensitive) requires an appropriate change antibacterial therapy.

In patients having increased sensitivity to penicillins, crosst allergic reactions with cephalosporin antibiotics.

When applying in high doses in patients with renal failure It is possible toxic effect on the central nervous system.

Features of the influence of the medicinal product on the ability to control the vehicle or potentially hazardous mechanisms

Oxep ® -Tatry does not affect the ability to control the vehicle and potentially hazardous mechanisms.

Overdose

Symptomsmanifestations of toxic action to the central nervous system (especially in patients with renal failure); Nausea, vomiting, diarrhea, impaired water and electrolyte balance.

Treatment -symptomatic. Exit with hemodialysis.

Release form and packaging

0.5 g of powder in vials with a capacity of 10 ml, hermetically sealed with rubber plugs, compressed caps aluminum or cap combined aluminum caps with plastic lids.

A trademark of the enterprise is applied on the plastic lid, made by casting under pressure.

50 bottles with 5 medical instructions in public and Russian are placed in a box of cardboard.

Storage conditions

Store in a dry, protected from light, at a temperature not higher than 20 ºС

Keep out of the reach of children!

Storage term

Do not use after the expiration date.

Conditions of vacation from pharmacies

On prescription

Manufacturer

OJSC Synthesis.

Russia, 640008, Kurgan, Constitution Avenue, 7

Owner of the registration certificate

OJSC "Synthesis", Russian Federation

Address of the organization hosting in the Republic of Kazakhstan Claims from consumers for product quality

STOFARM LLP, 000100, Republic of Kazakhstan,

Kostanay region, Kostanay, ul. Ural, 14.

tel. 714 228 01 79

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Composition and form of release of the drug

Capsules white color; Content capsules - white granules with a yellowish colors.

10 pieces. - Packaging cell contour (2) - packs cardboard.
20 pcs. - Polymeric banks (1) - packs cardboard.

pharmachologic effect

Combined antibiotic, which combines ampicillin and oxacillin action spectrum.

Ampicillin - A semi-synthetic penicillin, acts bacteric and acid resistant. Active against gram-positive, forming no penicillinase (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae), and Gram (Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Salmonella spp., Shigella spp., Proteus mirabilis, Haemophilus influenzae) microorganisms.

Oxacillin - penicillinase-resistant semi-synthetic antibiotic from a group of penicillins, acid resistant; It has a bactericidal action against gram-positive microorganisms (StareLococcus SPP., Streptococcus SPP., incl. Streptococcus Pneumoniae, Actinimyces SPP., Bacillus Anthracis, Corynebacterium Diphtheriae, Anaerobic Spore-forming Chopsticks, incl. Clostridium), gram-negative Cockkops (Neisseria Gonorrhoeae, Neisseria Meningitidis), Escherichia Coli, Proteus Mirabilis, Haemophilus Influenzae, Klebsiella Pneumoniae, Actinomyces SPP., Treponema SPP.

To the action of a combination of resistant Pseudomonas Aeruginosa and other non-enmented gram-negative bacteria, most Proteus Vulgaris strains, Providencia Rettgeri, Morganella Morganii.

Pharmacokinetics

T Cmax both antibiotics in the blood - 0.5-1 h after the introduction. When I / in the introduction in the blood, the concentrations of the drug are rapidly created, exceeding those in the introduction.

Both antibiotics are removed by the kidneys, partly with bile. With repeated administrations do not cumulative.

Indications

Bacterial infections caused by sensitive pathogens: sinusitis, tonsillitis, medium otitis; bronchitis, pneumonia; cholegitis, cholecystitis; pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, cervicitis; Infectilation of the skin and soft tissues: the face, impetigo, secondly infected dermatoses, etc.

Prevention of postoperative complications in surgical interventions (including on the background of immunodeficiency), infections in newborns (infection of the ammunition fluid; breach of the newborn breathing, requiring the use of resuscitation measures; the risk of aspiration pneumonia).

Heavy flowing infections (sepsis, endocarditis, meningitis, postpartum infection).

Contraindications

Increased sensitivity to the components of the drug; ; Lympholoicosis.

Carefully

Chronic renal failure, children born in mothers with hypersensitivity to penicillins.

Dosage

Inside, a one-time dose for adults and children over 14 years old - 0.5-1 g, daily - 2-4 years old for 3-7 years - 100 mg / kg / day, 7-14 years old - 50 mg / kg / day. The duration of treatment is from 5-7 days to 2 weeks. The daily dose is divided by 4-6 receptions.

In / m and in / in (stroke, drip), daily dose for adults and children over 14 years old - 3-6 g; For newborns, premature and children up to 1 year - 100-200 mg / kg / day; 1-6 years - 100 mg / kg / day; 7-14 years old - 100 mg / kg / day. The daily dose is introduced in 3-4 receptions, with an interval of 6-8 hours. If necessary, the specified doses can be increased by 1.5-2 times.

For the introduction of the content of the vial content (0.2 and 0.5 g) is dissolved in 2 and 5 ml of water for injection, respectively.

For in / in inkjet administration (for 2-3 minutes), a one-time dose is dissolved in 10-15 ml of water for injection or 0.9% solution.

For in / in drip administration, an adult dose is dissolved in 100-200 ml of 0.9% NaCl solution or a 5% solution of dextrose and administered at a speed of 60-80 CAP / min; Children as a solvent use 30-100 ml of 5-10% declaration solution. The drug is introduced 5-7 days, followed by a transition to a / m or oral administration.

Side effects

Allergic reactions: urticaria, skin hyperemia, angioedema swelling, rhinitis, conjunctivitis; Fever, arthralgia, eosinophilia, in rare cases - anaphylactic shock;

From side digestive system: Changing taste, nausea, vomiting, diarrhea, rarely - pseudo-membrane enterocolitis,

From the hematopopitation system: leukopenia, neutropenia, anemia.

General reactions: Superinfection, dysbacteriosis.

Local reactions: Flebit and perifelbit (with / in administration); At the / m - at the injection site infiltrate, soreness.

Medicinal interaction

Antacids, glucosamine, laxatives, food, aminoglycosides (when taking inside) slow down and reduce absorption; Increases absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) - synergism of action; bacteriostatic drugs (macrolides, chloramphenicol, lincoosamide, tetracyclines, sulfonamides) - antagonism of action.

Increases efficiency indirect (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); Reduces the effectiveness of oral contraceptives, drugs, in the process of metabolism of which PABK is formed, ethinyl estradiol - the risk of developing bleeding "breakthrough".

Diuretics, Channel Secrecy Blockers, Phenylbutazone, NSAID and other medicines blocking the channel secretion, The concentration of the drug in plasma increases, which increases the risk of toxic.

Allopurinol - Increased risk of skin rash.

special instructions

In case treatment, it is necessary to monitor the condition of the function of the blood formation organs, liver and kidneys.

The possibility of the development of superinfection (due to the growth of microflora insensitive to it) requires an appropriate change in antibacterial therapy.

In patients having increased sensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

When applied in high doses in patients with renal failure, a toxic effect on the CNS is possible.

Registration number: LCP-004808 / 10-270510

Trade name of the drug: Oxep ® -Tatry

International unpatient name or grouping name: Ampicillin + oxacillin

Dosage form: Powder for preparing a solution for intravenous and intramuscular administration.

Structure:
Active substance :
Ampicillin sodium 667,0 mg
(in terms of ampicillin)
Excipients:
Oxacillin sodium 333.0 mg
(in terms of oxacillin)

Description: White powder with yellowish color tint.

Pharmacotherapeutic group: Antibiotic combined (penicillins semi-synthetic)
ATX code J01Cr50

Pharmacological properties
Pharmacodynamics
Combined antibiotic combining ampicillin and oxacillin action spectrum.
Ampicillin is a semi-synthetic penicillin, a bactericidal, acid resistant. Active against gram-positive, forming no penicillinase (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae), and Gram (Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Salmonella spp., Shigella spp., Proteus mirabilis, Haemophilus influenzae) microorganisms. Oxacillin is a penicillinase-resistant semi-synthetic antibiotic from a group of penicillins, acid resistant; It has a bactericidal action against gram-positive microorganisms (StareLococcus SPP., Streptococcus SPP., incl. Streptococcus Pneumoniae, Actinomyces SPP., Bacillus Anthracis, Corynebacterium Diphtheriae, anaerobic sprouting sticks, incl. Clostridium SPP.), Gram-negative Cockkops ; Escherichia Coli, Proteus Mirabilis, Haemophilus Influenzae, Klebsiella Pneumoniae, Actinomyces SPP., Treponema SPP.
The action of the drug is stable Pseudomonas Aeruginosa, and others. Nefering gram-negative bacteria, most Proteus Vulgaris strains, Providencia Rettgeri, Morganella Morganii.

Pharmacokinetics
The time to achieve maximum concentration (TC MAH) of both antibiotics in the blood is 0.5-1 hours after intramuscular administration. Half-life - 1-2 hours. The drug penetrates well into different organs and fabrics. With intravenous administration in the blood, the concentrations of the drug are created, exceeding those with intramuscular administration. Both antibiotics are removed by the kidneys, partly with bile. With repeated administrations do not cumulative.

Indications for use
Infectious inflammatory diseases caused by sensitive pathogens: sinusitis, tonsillitis, average otitis; bronchitis, pneumonia; cholegitis, cholecystitis; pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, cervicitis; Skin and soft tissue infections: Family, impetigo, secondary infected dermatoses and others.
Prevention of postoperative complications in surgical interventions (including on the background of immunodeficiency), infections in newborns (infection of the ammunition fluid; breach of the newborn breathing, requiring the use of resuscitation measures; the risk of aspiration pneumonia).
Septis, endocarditis, meningitis, postpartum infection.

Contraindications
Hypersensitivity, infectious mononucleosis, lympholoikosis.

Carefully
Children who are born in mothers with hypersensitivity to penicillins. Allergic reactions in history and / or bronchial asthma, renal failure, a history of anamnesis, enterocolit on the background of the use of antibiotics (a history).

Pregnancy and lactation period
The use of the drug during pregnancy is possible only when the alleged benefit for the mother exceeds the potential risk to the fetus.
If necessary, prescribe a drug during lactation should be stopped breast-feeding (stands out with breast milk).

Method of application and dose
Intramuscularly and intravenously (inkjano or drip).
The doses of the drug referred to below are the sum of the dosages of ampicillin and oxacillin (sodium salts) in their fixed ratio 2: 1 (i.e., in the dosages below, 1 g of the drug is equal to the amount of 667.0 mg of ampicillin + 333.0 mg of oxacillin).
Daily dose for adults and children over 14 years old - 3-6 g; For newborns, premature and children up to 1 year - 100-200 mg / kg / day; 1-6 years - 100 mg / kg / day; 714 years - 50 mg / kg / day. The daily dose is introduced in 3-4 administration, with an interval of 6-8 hours.
If necessary, the specified doses can be increased 1.5-2 times.
The duration of treatment depends on the severity of the disease (from 5-10 days to 2-3 weeks, and in chronic processes - for several months).
For intramuscular administration, the contents of the vial are dissolved in 10 ml of water for injection.
For intravenous jet administration (for 2-3 minutes), one-time is dissolved in 10-15 ml of water for injection or 0.9% sodium chloride solution.
For intravenous drip administration, an adult dose is dissolved in 100-200 ml of 0.9% solution of sodium chloride or a 5% dextrose solution (glucose) and introduced at a speed of 60-80 CAP / min; Children as a solvent use 30-100 ml of 5-10% declaration solution (glucose). Intravenously introduced 5-7 days, followed by the transition to intramuscular administration.
Solutions are used immediately after cooking.

Side effects
Allergic reactions: Itching and skin peeling, urticaria, skin hyperemia, rhinitis, conjunctivitis, angioedema edema, rarely - fever, arthralgia, eosinophilia, erythematous and maculopapulous rash, exfoliative dermatitis, multiform exudative erythema (including Stevens-Johnson syndrome), reactions , similar to serum disease, in isolated cases anaphylactic shock, non-allergic ampicillin rash, can disappear without cancellation of the drug.
From the gastrointestinal tract: Dysbacteriosis, a change in taste, vomiting, nausea, diarrhea, moderate increase in the activity of "liver" transaminases, rarely - pseudomambranous colitis.
Laboratory indicators: leukopenia, neutropenia, anemia, hematuria, proteinuria.
Local reactions: pain in the place of administration, phlebitis and perifelbitis (with intravenous administration); With intramuscular - in the place of introduction of infiltrate.
Others: Interstitial jade, nephropathy, superinfection (especially in patients with chronic diseases or reduced organism resistance), vaginal candidiasis.

Overdose
Symptoms:
- manifestations of toxic effect on the central nervous system (especially in patients with renal failure): headache, tremor, convulsions;
- Nausea, vomiting, diarrhea, violation of the water and electrolyte balance.
Treatment: symptomatic. Exit with hemodialysis.

Interaction with other medicines
Ampicillin. Pharmaceutically incompatible with aminoglycosides.
Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) have a synergistic effect; Bacteriostatic preparations (macrolides, chloramphenicol, lincoosamides, tetracycles, sulfonamides) - antagonistic.
Increases the efficiency of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); Reduces the effectiveness of estrogen-containing oral contraceptives, drugs, in the process of metabolism of which para-aminobenzoic acid is formed, ethinyl estradiol (in the latter case, the risk of developing "breakthrough" bleeding).
Diuretics, Allopurinol, Oxyphenbutayon, Phenylbutazone Nonteroidal anti-inflammatory preparations and other drugs that block the channel secretion increase the concentration of ampicillin in the plasma (due to the decrease in the tubing secretion).
Allopurinol increases the risk of skin rash.
Reduces clearance and increases the toxicity of methotrexate.
Oxacillin. Increases the toxicity of methotrexate (competition for the canal secretion); It may be necessary to increase the doses of folinate calcium (antagonist antagonists antagonists) and its longer use.
It is necessary to avoid co-use with other drugs that have a hepatotoxic effect.
It is not recommended to be prescribed simultaneously with bacteriostatic antibiotics (reducing efficiency).
Drugs that block the tubular secretion increase the concentration of oxacillin in the blood.

special instructions
In case treatment, it is necessary to monitor the condition of the function of the blood formation organs, liver and kidneys.
When signs of anaphylactic shock appear, urgent measures should be taken to remove the patient from this state: the introduction of epinephrine (adrenaline), glucocorticosteroids (hydrocortisone or prednisone) and antihistamine, if necessary, performed artificial ventilation of the lungs.
The possibility of the development of superinfection (due to the growth of microflora insensitive) requires an appropriate change in antibacterial therapy.
In patients having increased sensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.
When applied in high doses in patients with renal failure, a toxic effect on the central nervous system is possible.

Form release
Powder for preparing a solution for intravenous and intramuscular administration of 667.0 mg + 333.0 mg.
667.0 mg + 333.0 mg in vials with a capacity of 10 ml or 20 ml, hermetically sealed with rubber plugs, compressed aluminum caps, or combined aluminum caps with plastic covers. 5 bottles are placed in the contour cellular packing from the film polyvinyl chloride.
1, 5 or 10 bottles or 1, 2 contour cellular packages with instructions for use are placed in a pack of cardboard.
50 bottles with 5 instructions for use are placed in a box of cardboard for delivery to hospitals.

Storage conditions
List B. In a dry, light-protected place at a temperature not higher than 20 ° C.
Store in places inaccessible to children.

Shelf life
2 years. Do not use after the expiration date.

Conditions of vacation from pharmacies
On prescription.

Manufacturer / Organization accepting complaints:
JSC "Joint Stock Kurgan Society medical preparations and products "Synthesis" (Synthesis OJSC).
Russia 640008, Kurgan, Pr. Constitution, 7