Tetracycline from what. Tetracycline: instructions for use

Tetracycline - antibiotic drug.

Release form and composition

Tetracycline is released in the following dosage forms:

• Eye ointment 1% (3, 5 or 10 g in aluminum tubes, 1 tube in cardboard pack);
• Outfolding ointment 3% (10 g or 15 g in aluminum tubes, 1 tube in cardboard pack);
• Sheath-covered tablets: pink, round, double-screw (10 pcs. In contour cellular packs, 2 or 4 packs in a cardboard pack; 20 pcs. In polymeric banks, 1 bank in a cardboard pack).

1 tablet composition:

• Active substance: Tetracycline - 0.1 g;
• Auxiliary components: sucrose, corn starch, talc, acid red 2c, main carbonate magnesium, dextrin, calcium stearate, gelatin, Tropheolin O.

Composition 100 g ointment eye:

• Active substance: Tetracycline - 1 g;
• Auxiliary components: Vaseline, anhydrous lanolin.

The composition of 100 g of ointment for outdoor use:

• Active substance: Tetracycline - 3 g;
• Auxiliary components: Vaseline, anhydrous lanolin, sodium sulfur-sour pyrocerezin, paraffin.

Indications for use

Tetracycline in the form of tablets are prescribed for the treatment of the following diseases:

• Osteomyelitis;
• Pyelonephritis, cholecystitis, intestinal infections;
• Endometritis, endocarditis, prostatitis;
• Purulent infections of soft tissues;
• Brucellosis, syphilis, pertussus, gonorrhea, actinomycosis, rickettsiosis, ornithosis;
• Conjunctivitis, trachoma, blufarite;
• Stomatitis, tonsillitis, pharyngitis, otitis, gingivitis;
• Infectious diseases caused by microflora-sensitive drug: Empiama pleura, bronchitis, pneumonia, tracheitis;
• Furunculosis, acne, infected eczema, folliculitis.

The eye ointment is used in the treatment of bacterial and chlamydial eye infections, including keratoconjunctivitis, bluperoconjunctivitis, blepharitis, keratitis, trachom, meibomit, eye damage during pink echs.

Outwardly tetracycline in the form of ointments are prescribed in the treatment of purulent infections of soft tissues infected with eczema, furunculose, rashes, acneFolliculitis.

Contraindications

Tetracycline is contraindicated to apply in the presence of hypersensitivity to the components of the drug.

The preparation in the form of tablets can also be taken with nursing and pregnant women, children up to 8 children and patients with leukopenia. Patients with renal deficiency of the tablet should be used with caution.

Eye ointment Children can be used only after the ratio of the estimated benefit from the drug with a possible risk.

Method of application and dosage

Tetracycline tablets are taken inside by drinking a large amount of liquid.

Adults, as a rule, are prescribed 4 times a day at 0.25-0.5 g or 2 times a day (every 12 hours) of 0.5-1 g. Maximum dose - 4 g per day. Children from 8 years are prescribed 4 times a day (every 6 hours) at 6.25-12.5 mg / kg or every 12 hours of 12.5-25 mg / kg.

In the treatment of acne, tetracycline is used by 0.5-2 g per day. With the improvement of the condition (usually after 3 weeks), the dose is gradually reduced to supporting - 0.125-1 g. Adequate remission of acne can be achieved during intermittent therapy or drug intake every other day.

With an uncomplicated gonor, the drug is prescribed in an initial one-time dose of 1.5 g, after which for 4 days every 6 hours of 0.5 g (total dose - 9 g).

In the treatment of brucellosis for 3 weeks every 6 hours, 0.5 g of tetracycline is shown simultaneously with intramuscular administration of 1 g of streptomycin (during the first week - every 12 hours, during the second week - 1 time per day).

For early syphilis For 15 days, 0.5 g of tetracycline should be taken every 6 hours, with a late syphilis, the drug is taken within 30 days.

With uncomplicated urethral, \u200b\u200brectal and endocervical infections caused by chlamydia trachomatis, the drug at a dose of 0.5 g should be taken 4 times a day for at least 7 days.

Tetracycline in the form of eye ointment is used locally, laying it every 2-4 hours or more often in the eyelid. The duration of therapy is determined by the disease (with trachoma - 1-2 months and longer, it is possible to simultaneously use with systemic effects).

Outside application ointment 1-2 times a day should be applied to the affected areas of the skin (possibly overlaying an occlusal dressing).

Side effects

When using tetracycline in the form of tablets, violations of some systems and organs may occur:

• Nervous System: Increased intracranial pressure, toxic effect on central nervous system (instability or dizziness);
• Digestive system: vomiting, anorexia, diarrhea, glossitis, nausea, esophagitis, gastritis, hepatotoxic effect, ulceration of the stomach and duodenal gut, dysphagia, nourishpiece hyperrophy, intestinal dysbacteriosis, pancreatitis, increase in activity of hepatic transaminases;
• Urinary system: hypercreaticinemia, azotemia;
• Blood formation organs: thrombocytopenia, hemolytic anemia, neutropenia;
• Immunopathological and allergic reactions: photosensibilization, angioedema swelling, maculo-papular rash, skin hyperemia, medicinal red lupus, anaphylactoid reactions;
• Others: hyperbilirubinemia, candidiasis, superinfection, a change in the color of dental enamel in children, lack of vitamins of group V.

When using eye ointment and ointments, allergic reactions are possible for external use.

special instructions

because of possible development Photosensibination requires restriction of insolation.

For long use Tetracycline periodically needs to control the functions of the liver, kidneys, blood formation organs.

Due to the fact that the drug can mask the manifestations of syphilis, with the possibility of mixed infection for 4 months it is necessary to carry out a monthly analysis.

Tetracyclines in any kosovye-forming tissue form resistant calcium complexes (CA 2+), so when taking the drug during the development of the teeth, long-term dental enamel staining in yellow-gray-brown color, as well as enamel hypoplasia are possible.

For the prevention of hypovitaminosis during the use of tablets, beer yeast must be prescribed, group vitamins B and K.

If within a few days of the use of eye ointment, the condition does not improve, you should consult with your doctor.

Outside application ointment is not recommended to apply with severe burns, crusted or deep wounds, in ophthalmology. During therapy, it is necessary to take into account that the use of outdoor antibacterial drugs It can lead to sensitization of the body, accompanied by the emergence of high sensitivity reactions. If for 14 days the condition does not improve, you need to consult with your doctor.

Medicinal interaction

Tetracycline absorption reduce antacids with aluminum, calcium and magnesium, swieraffiners, iron preparations.

The drug reduces the prothrombin index (dose reduction required indirect anticoagulantov), the effectiveness of bactericidal antibiotics, disturbing the synthesis of the cell wall (cephalosporins, penicillins), and estrogen-containing oral contraceptives (the risk of developing breakthrough bleeding) is increasing.

Terms and conditions of storage

Store in protected from light, dry, inaccessible to children.

Shelf life - 3 years at temperatures:

• Tablets: up to 25 ° C;
• Eye ointment: up to 15 ° C;
• Outdoor ointment: up to 20 ° C.

Tetracycline belongs to a number of bacteriostatic antibiotics. One of the forms of the product is tableted. The medication is active with respect to a wide range of gram-positive and gram-negative microorganisms. This causes widespread use of tetracycline in various therapeutic spheres for the treatment of a number of infectious lesions. Children up to 8 years old, pregnant women and women during lactation drug Admin Tetracycline is impossible.

Dosage form

One and dosage forms of production Tetracycline funds are tablets. The realization of the means is carried out in contour cellular packages (10 units of the medication in each). Two blisters are placed in cardboard packs, they are making instructions for use.

Description and composition

Tetracycline is pink tablets that have a film sheath, a circular shape and a biconimation.

The active component in the composition is an antibiotic tetracycline. Additional substances include:

• sucrose;
• corn starch;
• talc;
• magnesium carbonate;
• dextrin;
• calcium stearate;
• gelatin;
• acid red 2c;
• tropheolin O.

Pharmacological group

The main component of the medication refers to a number of bacteriostatic antibiotics of the category of tetracycline. Its mechanism of action is aimed at violations of the protein synthesis process in the bacterial cell.

Tetracycline is active in the fight against the following Gram-positive and Gram-negative microorganisms: Staphylococcus spp, Streptococcus spp, Listeria spp, Bacillus anthracis, Haemophilus influenzae, Escherichia coli, Haemophilus ducreyi, Bordetella pertussis, Enterobacter spp, Shigella spp, Klebsiella spp...... ., Salmonella SPP., Mita SPP., HERELLA SPP., Yersinia Pestis, Bacteroides SPP ... VIBRIO COMMA. Vibrio Fetus, Francisella Tularensis, Bartonella Bacilliformis, Borrelia Burgdorferi. Brucella species.

If the patient has contraindications to the use of a penicillin antibiotic group, then tetracycline is also prescribed to combat Clostridium SPP., Neisseria Gonorrhoeae. Actinomyces SPP., Mycoplasma SPP., Rickettsia SPP., Chlamydia SPP., Plasmodium Falciparum., Treponema SPP.

The following list of microorganisms has tetracycline resistance: Pseudomoivas Aeruginosa, Proteus SPP., Serratia SPP., most of Bacteroides SPP strains, beta hemolytic streptococci Group A.

The suction of the substance reaches 75-77%. This indicator is reduced when eating. The ability to establish links with blood proteins is 55-65%. The maximum concentration is achieved 2-3 hours after the reception and decreases over the next eight hours.

In small quantities, the substance is metabolized in the liver. The half-life is from 6 to 11 hours. It is noted the presence of a substance in the urine is already 2 hours after the admission. In the first 12 hours 10-20% of the substance is displayed by the kidneys.

Indications for use

The remedy is widely used for therapy of infectious lesions caused by microorganisms sensitive to tetracycline.

for adults

For adult patients, the following readings are valid:

• cholecystitis;
• intestinal infections;
• syphilis;
• whooping cough;
• ricketsiosis;
• ornithosis;
• osteomyelitis;
• conjuquitis;
• tonsillitis;
• gingivitis;
• infected eczema;
• folliculitis;
• empiama pleura;
• endocarditis;
• prostatitis;
• gonorrhea;
• brucellosis;
• actinomycosis;
• purulent infectious lesions of soft tissues;
• trachoma;
• blufarite;
• furunculosis;
• acne.

for kids

At the age of 8 years, tetracycline is contraindicated. In general, the list of diseases in which tetracycline is shown to children over 8, coincides with the list of lesions that act for the adult category of patients. However, the use of tetracycline in children can be used only by testing the doctor.

Application The drug of drug orientation tetracycline is prohibited for women who are in a state of having a child or breastfeeding it. The substance can penetrate the placental barrier and discovered in breast milk.

Contraindications

Contraindications include:

• pregnancy period;
• age up to 8 years;
• lactation period;
• leukopenia;
• intolerance to the components of the means.

Caution use tetracycline with renal failure.

Applications and doses

Medical drug Tetracycline is shown for oral reception. Tablets need to drink a large amount of fluid.

The extensive spectrum of indications for use explains the wide variation rate of dosing and reception modes in the case of therapy of different ailments. For more detailed description The method of use and necessary dosages need to contact medical institution For the consultation of the doctor.

for adults

Adults take from 0.25 to 0.5 g of medication every 6 hours. Another variant of the reception mode is the scheme: 0.5-1 g of substance twice a day through an interval 12 hours.

The total amount of the drug adopted per day should not exceed 4 grams.

In case of acne, they are prescribed from 0.5 to 2 per day for several receptions. After about 20 days, the dosage is subjected to a decrease to 0.125-1.

With brucellosis, the patient takes 0.5 medicines every 6 hours for 3 weeks. In this case, tetracycline is usually combined with streptomycin.

Gonorrhea without complication requires a reception of 1.5 g as an initial one-time dosage, and then use 0.5 g of the drug 4 times a day for 4 days.

When syphilis, the reception lead 4 times a day for 0.5 grams. The course of treatment is 2 weeks and 4 weeks for early and late syphilis, respectively.

With endocervical, urethral and rectal infectious lesions of an uncomplicated nature, they prescribe 0.5 grams of funds every 6 hours for no less than the weeks.

for kids

Children over 8 years old are used from 6.25 to 12.5 mg per kilogram of body weight 4 times a day with uniform intervals. A different method of reception is the use of 12.5-25 mg per kg of mass twice a day.

for pregnant women and during lactation

Pregnancy and lactation time are contraindications for receiving tetracycline.

Side effects

Against the background of use medication Tetracycline may arise the following side effects:

• anorexia;
• an increase in intracranial pressure;
• hemolytic anemia;
• azotemia;
• maculo-Papulse rash;
• superinfection;
• glossitis;
• dizziness;
• thrombocytopenia;
• gastritis;
• hyperrematininemia;
• hyperemia;
• candidiasis;
• diarrhea;
• dysphagia;
• neurophenia;
• swelling quinque;
• gastric ulcer and duodenal intestine;
• pancreatitis;
• nausea;
• anaphylactic reactions;
• a shortage of vitamins of a number in;
• increasing the activity of transaminase in the liver;
• lupus erythematosus;
• ezophagitis;
• dysphagia;
• changing the color of the teeth in patients in childhood;
• intestinal dysbacteriosis;
• hyperbilirubinemia;
• photosensibilization;
• hepatotoxic reactions;
• hypertrophy of the papillas of the language.

Interaction with other medicines

Antacid drugs that contain aluminum, magnesium, calcium, as well as iron medications and swiveramins adversely affect tetracycline absorption.

Against the background of using tetracycline, the prothrombin index undergoes a decrease due to the suppression of the intestinal microflora, which requires lower dosages of indirect anticoagulating agents.

Tetracycline is able to reduce the effectiveness of antibiotics of the bactericidal series.

This agent is combined drug, As part of which there are two antibiotics: tetracycline and oleandomycin. The means is implemented in the form of capsules. It is used to treat a variety of infections. Age up to 12 years is a contraindication to the use of the means.

The drug tigacil is produced as a powder for the preparation of an infusion solution. The drug refers to antibacterial agents for systemic use, to a row of tetracycline. The active substance in its composition is Taigcycline. Used for therapy of infectious lesions.

Price

The cost of tetracycline tablets is an average of 54 rubles. Prices fluctuate from 18 to 124 rubles.

Latin name: TetracyCline
ATH code: S01AA09.
Active substance:
Manufacturer: BelmedPreparations
Belarus, etc.
Pharmacy vacation condition: On prescription
Price: from 30 to 130 rubles.

"Tetracycline" - an antibiotic with a wide range of action. Used to treat infectious inflammatory diseases.

Indications for use

The drug is appointed with such diseases: intestinal infections, external eye inflammation, leather, lung shells (pleurisy), acne, gonorrhea, prostatitis, endometritis, syphilis, purulent infections, trachoma.

Also shown at: tetanus, botulus, conjunctivitis, brucellosis, granuloma and other diseases, which are sensitive to antibiotics of this group.

Structure

The tablets include tetracycline and such auxiliary substances like: vanillin, cocoa, water, sucrose, talc, gelatin, starch potato, calcium starath monohydrate.

As part of the eye ointment there is tetracycline in the amount of 10 mg, as well as anhydrous lanolin, vaseline.

Medical properties

Like other drugs, which belong to the tetracycline group is an antibiotic with an antibacterial effect, a wide range of diseases treats a wide range of diseases. Actively interacts with gram-positive and gramiterite 9l microorganisms, as well as other pathogens infectious diseases, including the STD (sexually transmitted diseases), and other bacteria sensitive to antibiotics.

Antibiotics of this class are derived from both cultural and artificial way. It is considered no less effective than the new generation of antibiotics.

It is used in veterinary medicine. Veterinarians give it chickens, calves, sands, apply in the treatment of young domestic animals.

The average price is from 90 to 130 rubles.

Tetracycline tablets and capsules

In one capsule contains 0.25 g of the active substance (not produced by domestic pharmacists). In tablets, 0.05 is also added to this dosage; 0.125 and 1 g. Tablets have pink or brown (depending on the manufacturer), round shape.

The average price is from 4500 to 6000 rubles.

Mode of application

Capsules take 1-2 pieces 4 times a day or 2-4 every 12 hours (based on the recommendation of the attending physician). The maximum allowable dose per day is 4 g. Swallow capsules should not be delayed.

Tablets: adults take 0.2-0.25 g 3-4 times a day, drinking water. Children give 20-25 mg from the calculation of 1 kg of weight per day. The course of treatment lasts from 5 to 7 days.

After the symptoms pass, the drug should be continued to be taken over the next 1-3 days.

The average price is from 30 to 50 rubles.

Available in aluminum tubes of 10 or 15 grams. It can also be packed in glass jars at 25 or 45. The concentration of the substance in it reaches 3%. Mazi color - white, possibly yellowish or brown shade. To the touch is thick.

The domestic manufacturer Synthesis produces her called Tetracycline-AKOS.

Mode of application

The ointment is used externally, on damaged skin areas 1-2 times a day. If the patient uses ointment tetracycline from acne during acne rash, the duration of treatment can be from 3-4 to 14 days, depending on the complexity of inflammation.

The average price from 50 to 70 rubles.

Tetracycline eye ointment

Produced in tubes of 3 or 10 grams. The concentration of eye ointment differs from usual and is 1%. External properties are similar to simple tetracycline ointment.

Mode of application

Apply the drug locally. Apply every 2-4 hours for the lower eyelid (on every eye). The duration of treatment depends on the form of the disease. Sometimes it can reach the term of one or even two months (during the tracher).

Contraindications

The prohibition of reception is: liver failure, pregnancy, lactation period. Contraindicated children early age (can only after 8 years).

During pregnancy and breastfeeding

The use of tetracycline pregnant and women, nursing breast milk, undesirable. Active substances Tetracycline preparation in most forms penetrate the placental barrier, which negatively affects the health of the fetus; And also on the color of the teeth, the quality of the dental enamel and fat fibilization of the woman's liver. Eye drops And ointments are not dangerous, as a small amount of medication is in the body.

Precautions

Avoid direct contact with sunlight, in order to avoid strong photosensitivity. Do not apply ointment with heavy burns and deep wounds.

If a few days after the use of eye ointment, the clarity of vision was not restored, it should be advised to be consulted. For the prevention of possible hypovitaminosis, it is recommended to use the vitamins of groups B and K. to refrain from driving transport and actions requiring a high reaction and concentration of attention.

Due to the fact that the drug can mask symptoms of syphilis, in order to avoid mixed infections, it is necessary to take an analysis of sermarkers for 4 months. Also need control over the functioning of the kidneys, intestines, liver, blood circulation.

The determination of authenticity is carried out by reaction with iron ions.

Cross drug interactions

It is not recommended, due to the avoidance of an acidic reaction, taking tetracycline complex with preparations containing metal ions, which relate to acid-sensitive; as well as bactericidal preparations: Penicillin groups, cephalosporin.

Tetracycline is ineffective when interacting with a skewer, a whiff; If tetracycline and retinol are simultaneously taken, it may lead to an increase in intracranial pressure.

In veterinary purposes

Tetracycline hydrochloride is used in the treatment of animals: birds (in particular chickens) and cattle. Form: powder in a sealed bottle with a capacity of 20 ml, with a rubberized strong lid.

Chickens and chickens when blocking the intestines are allowed to drink 20-30 grams diluted in water (crushed into pills powder). When inflammation (redness), the eye chickens prescribe eye ointment.

If there are problems with the respiration organs of chickens and chickens (wheezes, colds, trachea inflammation, bronchi, lungs), also recommended for chickens to drink tetracycline powder, divorced in water.

In the treatment of calves from pneumonia, pasteurosis, colibacteriosis and other diseases sensitive to antibiotics of the tetracycline group, calves are given by 20 mg of the drug twice within a week. It is not recommended to slaughter calves and chickens on meat, if not passed a week since the last reception of the drug. Meat killed calves and chickens until the deadline can be used as food for fur animals or for making meat-bone flour.

Side effects

how adverse reactions Possible: vomiting, redness of the skin, rash, diarrhea, anorexia, abdominal pain, constipation, dryness in the oral cavity, change in the color of the surface of the tongue and dental enamel, headache, dizziness, skin itch. Eveny, increased light sensitivity, hypovitaminosis, intestinal dysbacteriosis, rapid heartbeat, high blood pressure, instability, scattering attention, slower reaction, passivity, allergic reactions, neutropenia, pancreatitis, 12-russian ulcer.

Overdose

When the specified norm is exceeded, both for people and animals can be observed the increasing side effects listed above. In this case, you need to start symptomatic treatment.

Conditions and shelf life

Store no more than 3 years in a dry place at a temperature not exceeding 20 C.

Analogs

Tetracycline has many analogues with similar properties and perform the same function. The list of drugs that are written out along with tetracycline:

NIFARM, Russia
Price from 115 to 150 rubles.

"Levomecole" - ointment for outdoor use with antibacterial effect, refers to the new generation of antiseptics. In the treatment of animals, levomexol has a regenerating effect and treats other purulent-inflammatory diseases. Give chickens when the eyes are fed.

It is used by the levomecole by applying ointment on the napkin and the subsequent wound blotch, applies both as an eye ointment.

pros

• High shelf life
• Cheap preparation

Minuses

• A narrower spectrum of action than tetracycline
• One form of release
• Animals are allergic to Levomekol.

Dalkhimfarm OJSC, Russia
Price from 10 to 300 rubles.

Antibiotic (4th generation) for local application In order to treat eye. "Levomycetin" treats and warns such eye ailments as conjunctivitis, keratitis. "Levomycithi" n is active even with respect to those bacteria that are resistant to antibiotics of a group of tetracycline, sulfaneids, penicillins. Used "Levomycetin" and for the treatment of animals (give calves, sands, chickens).

pros

• Lower price (from 15 rubles)
• Easy absorbed (especially drops)

Minuses

• "Levomycetin" is useless when combating acid resistant bacteria
• The bitter taste of tablets is extremely important to quickly swallow the tablet or drink a significant amount of water.

Biosynthesis, Russia, etc.
Price from 70 to 100 rubles.

Antimicrobial drug. Absolute synonym for tetracycline (base). It can be used both inside and externally. Produced in tablets, mortar and powder for cooking.

pros

• Drazability in water in tetracycline hydrochloride is higher than just tetracycline
• For intramuscular administration The antibiotic is absorbed in half an hour and is completely removed from the urine in 10-12 hours.

Minuses

• Tetracycline hydrochloride loses activity in the solution very quickly, so it should be used immediately after the manufacture of the solution
• In the injection site, seals may occur - then the hydrochloride tetracycline should be stopped.

Tetracycline-Belmed - antibiotic. The active ingredient, tetracycline hydrochloride, refers to one of the drug groups - antibacterial agents for systemic use, tetracycline.
Tetracycline-Belmed is used to treat the following infections:
infection respiratory tract, such as pneumonia, bronchitis and cough
infection urinary tract
sexually transmitted diseases such as chlamydial infection, Gonorrhea and Syphilis
skin infections such as acne
Eye infection, such as conjunctivitis
infections caused by rickettsies, such as fever ku and ticking fever
Other infections, including brucellosis, ornithosis, plague, cholera, leptospirosis, gas gadget, tetanus.

Do not take the drug if

You are allergic to tetracycline, other similar antibiotics (such as minocycline, doxycycline) or another component of this drug, specified in the section "Composition"
You for a long time suffer from diseases of the kidneys or liver or you have a severe kidney disease
You have a systemic red lupus - a disease in which rash is observed (especially on the face), hair loss, fever, discomfort and joint pain
You have less than 18 years
You are pregnant or breastfeed
You have reduced the number of leukocytes in the blood

special instructions and precautions "Type \u003d" Checkbox "\u003e

Special instructions and precautions

Before applying the drug Tetracycline-Belmed; Consult with your attending physician if:
You have myasthenia gravis - a disease for which muscle weakness is characterized, the difficulty of chewing and swallowing, an inadvertent speech
You suffer from kidney or liver diseases
you increased sensitivity To sunlight

Tetracycline-Belmed contains food dyes Karmuzin Lake and Pono 4R Lake, which can cause an allergic reaction.

Other Preparations and Tetracycline-Belmed

Consult with your doctor if you accept, recently accepted or you can start taking any other drugs. This also applies to any drugs discharged without a doctor's prescription. Consult with your doctor if you apply:
Penicillins, such as amoxicillin, flukloxacillin, phenoxymethylpenicillin
Cephalosporins, such as Ceftriaxon, Cefazolin, Cefpin, Cefalexin, Cephissim and others
vitamin A
Retinoides, such as tertinoin and adapal, which are used to treat eczema, acne and other skin diseases
Preparations for thinning blood and preventing the formation of thromboms such as Warfarin and Phoenindion
Preparations that strengthen urine release (diuretics), such as furosemide and spironolactone
Preparations for the treatment of diarrhea, such as kaolin-pectin and bismuth subsalicylate
Hymmipcin, which is used to treat purulent diseases
Preparations for treating diabetes, such as insulin, glyclaside and tollyatamide
drugs that can cause damage to the liver (find out from a doctor if it applies to drugs that you take)
Atovakvon, which is used to treat pneumonia
Theophylline used for the treatment of diseases of the respiratory system
Barbiturates and other medicines received for cramps such as carbamazepine, diphenylhydantoin and prison
Antacids, which are used to treat digestive disorders and heartburn, as well as any drugs containing aluminum, calcium, iron, magnesium, bismuth or zinc, because They can reduce the effectiveness of the drug Tetracycline-Belmed
Sukralfat, which is used to treat ulcers
Lithium, which is used to treat psyche disorders
Digoxin, which is used to treat arrhythmia and heart failure
Methotrexate, which is used for treatment rheumatoid arthritis
Strontium Rannel, which is used for the treatment of osteoporosis
Colestipol, swieramin, which are used to reduce cholesterol
Ergotamine and Metisrigid, which are used for the treatment and prevention of migraine
Metoxifluran (anesthetic). If you need an operation, let me know a doctor or a dentist that tetracycline-Belmed
Tetracycline-Belmed can reduce the effectiveness of oral contraceptives. During treatment, additionally use another contraceptive method.

Tetracycline-Belmed with food, beverages and alcohol
The drug should be taken inside an hour before or 2 hours after meals.
Do not take tetracycline-whitemed together with food, milk or dairy products, because They can reduce the effectiveness of the drug.

Operations and analyzes
If you are treated for any disease, please inform your doctor or a dentist that Tetracycline-Belmed is taking.
With long-term treatment, it may be necessary to perform blood test, evaluation of the renal function and liver.

breast-feeding and fertility "Type \u003d" Checkbox "\u003e

Pregnancy, breastfeeding and fertility

If you are pregnant or breastfeed, you think that you can be pregnant, or you are planning a pregnancy, before the use of the drug, consult your attending physician.
Do not use this drug during pregnancy or breastfeeding if your attending doctor does not consider it necessary. Tetracycline-Belmed can affect the development of your child.

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Transportation of vehicles and work with mechanisms

Tetracycline-Belmed does not affect the ability to control vehicles and work with mechanisms.

Application

Always take this drug in full accordance with the recommendations of the attending physician. When doubt, consult with the attending physician.
Tetracycline-Belmed should be taken:
Your attending physician will tell you what dose is optimal for you, because It depends on your condition. Take Tetracycline-Belmed at least 10 days if your attending physician did not give you other recommendations.
Adults and elderly people:
250 mg every 6 hours. The first reception can be 500 mg (5 tablets). With severe infections, the doctor can assign you 500 mg (5 tablets) every 6 hours.
Features of use in some infections:
Skin infections: 250-500 mg per day for one or more receptions for 3 months
Brucellosis: 500 mg 4 times a day in combination with streptomycin
sexually transmitted diseases: 500 mg 4 times a day for 7-30 days depending on your condition
Application in children
Due to the presence of karmuzin (E-122) as part of the dye, Tetracycline-Belmed drug is contraindicated to use in children.
Tetracycline can cause long-term staining of the enamel of the teeth and affect the development of the skeleton bones.
Mode of application
Squeeze the tetracycline-Belmed glass of water an hour before or two hours after meals.
Swallow the tablet sitting or standing, do not take the drug immediately before bedtime.
If you applied Tetracycline-Belmed preparation more, it followed
If you have taken too much Tetracycline-Belmed, immediately consult a doctor. Overdose symptoms include nausea, crystals or blood in the urine, hypersensitivity reactions.
If you missed the reception of the drug Tetracycline-Belmed
If you missed Tetracycline-Belmed preparation, accept it as soon as remember this. But if it's almost the time next reception, Wait for the prescribed time and take the usual dose of the drug. Do not take a double dose to compensate for missed.
If you stop the reception of the drug Tetracycline-Belmed
Continue taking Tetracycline-Belmed as much as a doctor prescribed, even if you feel better. If you do not graduate a course of treatment, the infection may return.

Possible unwanted reactions

Like all drugs, Tetracycline-Belmed can cause unwanted reactions, but they do not occur.
Immediately stop taking Tetracycline-Belmed and consult a doctor if you feel any of the unwanted reactions below - you may need urgent health care:
Sudden swelling of lips, face, throat or language, rash, difficulty swallowing or breathing. These symptoms may be signs of severe allergic reaction (anaphylaxis) and can be life-threatening
Strong headache, dizziness, "ringing" in the ears, fuzzy vision, "dead zones" and bias in the eyes. These symptoms may be signs of high intracranial pressure
The rash similar to the target or circles, often with blisters in the center. Later, blisterings can cover a large area, skin peeling can begin. Ulcers can also be observed in the mouth, throat, nose or outdoor genital organs, redness and swelling of the eyes (conjunctivitis), symptoms resembling flu. These phenomena are characteristic of Stevens-Johnson's syndrome and toxic epidermal necrolis, which carry a threat to life
worsening or loss of vision
Strong or long-term diarrhea with blood impurities or mucus - it may be a sign of severe intestinal inflammation
Abdominal pain and back can be a sign of inflammation of the pancreas (pancreatitis).
These unwanted reactions may occur:
Seldom(can manifest themselves less than 1 of 1,000 people);
Hepatic inflammation (hepatitis), liver failure, yellowing of skin or eye proteins (jaundice), change the liver function (determined by biochemical analysis blood)
Increased urea levels, phosphates or blood acidity, changes in the number and types of blood cells. If you notice the frequent appearance of bruises, bleeding, sore throat, infection, fever, permanent sense of fatigue, shortness of breath or unusual skin pallor - inform your doctor, you may need to perform blood test
sores in the throat, difficulty swallowing
Kidney problems causing urine change, fatigue, weakness, shortness of breath and swelling due to fluid delay in the body.
Frequency unknown (Frequency cannot be estimated based on available data):
Increased sensitivity to sunlight or artificial ultraviolet radiation, causing itching and burning skin. You should avoid sunlight and ultraviolet
Excessive growth of sustainable microorganisms, which leads to infections such as thrush
Pseudomambranous colitis, the symptoms of which include diarrhea, discomfort in the abdomen and an increase in body temperature
The exacerbation of the system of red lupus, which is manifested by a rash, fever and pain in the joints
Strengthening muscle weakness in patients suffering from myasthenia gravis
headache
Stomach disorder, nausea, diarrhea, loss of appetite, staining of the enamel of teeth, inflammation of the pancreas (pancreatitis), which cause discomfort and abdominal pain
Violation of the kidney function, which leads to a change in the frequency of urination, swelling of the legs or ankles
fatty dystrophy Liver, which causes a sense of fatigue and pain in the top of the belly
color change thyroid gland (It is not known whether its function is disturbed).
Message about unwanted reactions
If you have any unwanted reactions, consult your doctor. It also applies to any side effects that are not specified in this liner. You can also report unwanted reactions to the information database for unwanted reactions (actions) for drugs, including messages about inefficiency. medicinal preparationsidentified on the territory of the state "Center Expertise and Health Testing Center of the Ministry of Health of RB", RCeth.BY). Reporting about unwanted reactions, you help to get more information about the safety of the drug.

Structure

Active substance Tetracycline-Belmed drug is a tetracycline hydrochloride - 100 mg.
Excipients: Potato starch, Pisidone K-25, Calcium Stearate, Sodium Laurilsulfate, Cellulose Microcrystalline, Aquarius Prefererred Pink. The composition of the shell Aquarius Prefererred Pink: hydroxypropylmethylcellulose, copovidone, polydektrosis, polyethylene glycol 3350, Caprilik / Cappick triglycerides (medium chain triglycerides), titanium dioxide, Karmuzin Lake (20-26%), Pono 4R Lake.

Appearance The drug and the contents of the package "Type \u003d" Checkbox "\u003e

Appearance of the drug and packaging content

Tablets covered with film shell, pink color, round, biconvenets. The core can be seen yellow color. On the surface of the tablets is allowed to roughness of the film coating.
10 tablets in the contour cellular packaging of polyvinyl chloride film and aluminum foil. One or two contour packages together with the liner is placed in a pack of cardboard.

Holder registration certificate and manufacturer:
RUE "BelmedPreparats",
Republic of Belarus, 220007, Minsk,
ul. Fabrichus, 30, tel. / Fax: (+375 17) 220 37 16,

Despite the possibility of developing certain side effects, antibiotics remain indispensable drugs In the therapy of a number of diseases. This is usually inflammatory processes infectious genesis. And if more precisely, those caused by penetration into the body of pathogenic bacteria. Tetracycline - antibiotic, one of the most famous representatives of antimicrobial agents, which is a drug selection in the treatment, including diseases of the urinary system organs.

Main characteristics of the drug

There is a whole group of antibiotics called "Tetracycles". Substances similar to biological properties and chemical structure, however, although they have one pharmacological group, they are allocated from different sources.

Total B. pharmacological group Tetracycline row antibiotics are up to 40 titles. So, tetracyclines are of the following origin:

1. Natural. They were obtained in the first half of the XX century from the culture fluids of various actinobacteria - radiant mushrooms. This includes such antibiotics as chloroetracycline (biomycin, aureomycin), oxytetracycline (terrarsicin), tetracycline (highlighted later than its synthesized analog).
2. Semi-synthetic. Allocate with the help of chemical manipulations with natural substances, in modern medicine They were widely used. This is also known to all of us tetracycline, as well as its derivatives (glycocyclin, morphocyclin), and synthesized by several later doxycycline, metacycline (rondomycin), minocycline.

Classification of tetracycline antibiotics

The active ingredient of the drug tetracycline is the chemical connection of the same name. Its effect, as in other representatives of this group of antibiotics, is the obstacle to the growth and reproduction of bacteria, as well as provocations for their death, which is called bacteriostatic and antibacterial influence, respectively. The mechanism of action of tetracycline is as follows:

• penetrate the cells of the microorganism;
• associated with the receptors of the small subunit of organelles responsible for the synthesis of protein - ribosomes (the process is reversible);
• block, in turn, the binding of structures carrying out the addition of new amino acids (structural units of proteins) to the resulting peptide chain;
• as a result - the synthesis of protein is disturbed.

Such malfunctions can lead not only to the inability of bacteria to reproduction, but also the earliest death. Unfortunately, such an effect is observed not only in relation to pathogenic microorganisms. The serious problem of applying the tetracycline drug is possible negative effects on their own useful human body microflora. Its degree largely depends on dosage form drug, they are as follows:

In addition, the negative effect of antibiotic reception can manifest itself in the form of:

• dizziness:
• allergic reactions;
• increase sensitivity to light;
• candidose vagina and oral cavity;
• detection enamel defects (brown or yellow tint of teeth - the drug is able to bind to calcium);
• increasing intracranial pressure;
• delays in growth and education bone tissue in children.

Indications and contraindications to the use of the drug

As antibiotic wide spectrum Actions, to the use of tetracycline readings are quite extensive. It is effective against a large number of pathogenic microorganisms, some of which can cause many various diseases. If you split them by authorities and systems, the following picture will be obtained:

Specific diseases such as plague, syphilis, tularemia, Siberian ulcers affect various organs. The form of the disease will depend on the place of the entrance gate of infection, the duration and path of its further distribution.

As already noted, antibiotics can cause various side effects and have a serious burden on the body, and therefore they have certain restrictions on use. For tetracycline contraindications are as follows:

• pregnancy and lactation period;
• violation of the functioning of the liver;
• various fungal diseases;
• reduced number of leukocytes in the blood;
• age up to 8 years;
• increased sensitivity to this drug.

Features of the use of antibiotic

Among the pathologies of the urinary system of the disease of bacterial nature are quite common. At the stage of determining the tactics of the fight against infection, it is very important to maintain an individual approach:

In modern medicine, not natural, but semi-synthetic tetracycles, including in nephrological and urological practices, are increasingly used. Thus, with cystitis, tetracycline, minocycline and doxycycline are selected from this group.

Important! How to drink them in the case of appointment, how long, with which periodicity and in which dose is determined by the attending physician. Any action contrary to its instructions may result in serious consequences.

As a rule, when cystitis accept:

According to research, in combination with others antibacterial agentsThe drug rolls indifference - its effectiveness will not change significantly, but before using any drugs during the course of receiving the antibiotic, it is necessary to consult with the doctor.

In annotations for tetracycline, the description of its action indicates that with the development of renal failure, the drug becomes toxic for urinating organs.

Therefore, as a rule, when glomerulonephritis and other diseases with a decrease in kidney functionality, this group of antibiotics is not assigned. It should be borne in mind that the stability of microorganisms is quite rapidly developing to tetracycles, which is, in most cases, the correction of the treatment regimen is required.