What is better lindinet 20 or 30. Birth control pills lindinet

"Lindinet 20" is a combination drug in the form of small round tablets. The pills are distinguished by their contraceptive effect, they are used for permanent planned contraception for women.

"Lindinet 20" and analogues in the ranking of drugs sold as contraceptives occupy a leading position. This is explained by the fact that research carried out by scientists has confirmed that these drugs are highly effective in protecting against unplanned pregnancy. When using them, the pregnancy rates do not exceed 0.05 per hundred women during one year of research.

What drugs can replace Lindinet 20?

Unconditional analogues of "Lindinet 20" in terms of the active substance in the composition, dosage form and dosage regimen are considered today:

• "Logest" is a drug that is also an oral contraceptive. White tablets are produced in France by Delpharm.
• Femoden is a highly effective estrogenic drug. Analogue of "Lindinet 20" in composition, but the dosage is increased. Manufactured in Germany by the Bayer team.
• Gestarella is a low-dose monophasic contraceptive drug. Manufacturer - "Abbott Laboratories" in Germany.

Of all the presented analogs "Lindinet 20" is the cheapest of all, but more on that below. The German pharmaceutical company Gedeon Richter also manufactures a drug of the same name but with increased content active element of ethinyl estradiol up to 0.03 mg per tablet - "Lindinet 30". Above in the photo is the analogue of Lindinet 20 - Logest.

The composition of contraceptives

"Lindinet 20" and similar medicinal preparations contain only 2 active components in composition - ethinylestradiol 0.02 mg and gestodene 0.075 mg. These two elements guarantee a reliable contraceptive result. The effect of estrogen-gestagenic tablets makes it possible to suppress the pituitary secretion of gonadotropins. In simple terms, the effect of the drug lies in the fact that both of these components do not allow the egg cell to form and mature. This effect prevents the possibility of fertilization.

The estrogenic effect of "Lindinet 20" and its analogs is caused by a highly effective component - ethinyl estradiol. it hormonal agent estrogenic series, which is produced naturally by the ovaries and adrenal glands in a woman's body. Together with progesterone, its tasks include stabilization menstrual cycle women, and among other things, also division, reproduction of endometrial cells and stimulation of the development of the uterus with insufficiency of the sex glands. The auxiliary function of ethinyl estradiol is to lower blood cholesterol levels.

Gestodene is an artificial substance similar in structure to levonorgestrel. It inhibits the synthesis of follitropin and blocks natural monthly ovulation. With the exception of the effects described above, birth control pills increase the viscosity of mucus in the cervix, preventing sperm from entering there.

From customer reviews: "Lindinet 20" and analogues, with systematic use, give not only the effect of a contraceptive, but also restore the menstrual cycle. They significantly reduce the risk of developing neoplasms in the pelvic organs and diseases of the woman's reproductive system. "Lindinet 20" and analogs for the active substance are drugs from the prescription group and can be used strictly as prescribed by the attending physician after a thorough examination of the patient.

Drug release form

The dosage form is realized in the form of glossy tablets of a faded yellow shade, film-coated. Round tablets without labels. The drug is produced in cardboard boxes. Inside the package there can be one or three blisters with tablets. It can be 21 tablets or 63. The manufacturing company "Lindinet 20" is from Hungary.

Indications for use

"Lindinet 20" and analogs are prescribed as modern remedy contraception. It can be used to normalize the menstrual cycle.

Contraindications and restrictions

The drug is not indicated for girls before puberty and women after menopause. Contraindications to taking "Lindinet 20" are the following chronic pathologies or diseases in history:

• hypersensitivity to single components of the drug or a combination of hormones from the composition;
• a clear predisposition or existing circumstances that provoke the formation of thrombosis;
• unstable performance blood pressure;
• coronary heart disease;
• frequent migraines with neurological symptoms;
• thrombotic or thromboembolic lesions of veins and arteries;
• thromboembolic lesions of veins in immediate family members;
• surgical interventioncausing prolonged immobility of the patient;
• damage to small vessels against the background of developing diabetes of all types;
• a state of inflammation of the pancreas, when the level of triglycerides in the blood is significantly overestimated;
• the formation of fatty deposits on the walls of blood vessels - dyslipidemic syndrome;
• diseases or severe inflammation of the liver and kidneys;
• yellow skin due to taking steroid medications;
• cholelithiasis;
• progressive genetic disease - ;
• neoplasms on the liver;
• capsule damage inner ear;
• hormone-sensitive neoplasms on the organs of the reproductive system or mammary glands;
• bleeding from the vagina;
• long-term smoking;
• pregnancy and postpartum period;
• lactation period.

In the following situations, according to doctors' reviews, "Lindinet 20" and analogs are allowed to be taken, but only if precautions are taken and under the supervision of the attending gynecologist:

• the patient is over 35 years old;
• conditions provoking the occurrence of thrombotic lesions of the veins;
• excess weight or obesity;
• migraine;
• hypertension;
• diabetes if vascular damage is excluded;
• ulcerative lesion of the colon;
• hereditary Quincke's edema;
• liver and kidney disease;
• diseases that worsened during pregnancy or from taking hormonal drugs;
• suffered severe trauma;
• varicose veins veins;
• pathological processes of heart valves;
• change in indicators biochemical analysis blood;
• sudden onset convulsive seizures;
• heart rhythm disturbances;
• prolonged immobility of the patient;
• extensive surgical intervention;
• liebman-Sachs disease (lupus erythematosus);
• coronary heart disease;
• severe depressive state;
• crohn's disease;
• hereditary violation of the structure of the hemoglobin protein;
• an increased level of triglycerides in the patient's blood;
• atypical hemolytic uremic syndrome;
• a short period of time after childbirth.

Method of application and dosage of the medicinal product and its analogues

According to the instructions, "Lindinet 20" and analogs are taken orally, washed down with a moderate amount of water or other liquid. Reception is carried out regardless of meals, one tablet once a day, preferably at the same time. After 21 days from the moment you start taking the pills, you must take a break for seven days. During a seven-day break from hormone use, withdrawal bleeding occurs (simulated menstruation). Then the tablets from the new blister are taken on the eighth day of the break.

If "Lindinet 20" is taken for the first time, then it is advisable to take the initial tablet from the blister from the first to the fifth day from the beginning of menstruation. In the first two weeks from the start of taking "Lindinet 20" and analog tablets, it is important to take advantage of contraceptive aids to avoid unwanted pregnancy.

Switching from other contraceptives

If the drug "Lindinet 20" is used as a substitute for another contraceptive, then the reception begins without a seven-day interval. That is, drinking the final pill from the pack of the previous drug, it is very important to start taking Lindinet 20 the next day. It is allowed to switch to "Lindinet 20" with "mini-pills" contraceptives any day. Nevertheless, in the first week of using "Lindinet 20" you should not pin your hopes on it, therefore it is better to use additional methods of contraception.

When sudden vomiting or diarrhea appears some time after taking the pill, the absorption of the drug is defective. If the symptomatology has ended within twelve hours, then it is advisable to take another pill and continue taking it according to the scheme. If symptoms last more than twelve hours, then additional contraception is imperative for the next seven days.

First trimester abortion

After an abortion in the first trimester, "Lindinet 20" is prescribed from the first day, immediately after the mechanical termination of pregnancy. In this case, there is no need for additional contraception.

Application after childbirth or after a second trimester abortion

Use "Lindinet 20" and analogs can be started 21-28 days after childbirth or abortion. It is allowed to start taking after childbirth only if the woman is not breastfeeding. If you start taking pills later than the specified period, you will need additional barrier protection against pregnancy within a week.

Delaying your period

In case of an urgent need to delay menstruation and prolong the cycle, you can resume taking pills from the next package without a seven-day break. The appearance of spotting bleeding in this case does not reduce the contraceptive effect.

From the instructions for the use of "Lindinet 20" and analogues: if the pill was not taken on time, and no more than twelve hours have passed since the moment of admission, then you need to drink the missed pill and continue taking the drug "Lindinet 20" according to the scheme. If more than twelve hours have passed, then the effectiveness of the drug as a contraceptive decreases, and it is recommended to use additional means of barrier contraception, for example, a condom.

Missed pill in the first and second week of the cycle: the next day, take two tablets at once and continue to take the drug regularly according to the scheme, applying additional protection until the end of the cycle. Missed tablet in the third week of the cycle: take the tablet and do not take a seven-day break before the next pack.

Side effects

During the reception of "Lindinet 20" and analogues, disturbances in the work of the following body functions often occur:

• Breast glands: aching pain from the side and from above, an increase in breast volume, discomfort, a feeling of heaviness, discharge from the nipples.
• The reproductive system - a change in libido (a decrease occurs much more often), inflammation in the vagina, the absence of menstruation after discontinuation of the drug, non-cyclic bloody smearing from the vagina.
• Disorders of the gastrointestinal tract: pain in the stomach, nausea, vomiting, diarrhea, inflammation of the colon, liver damage, bile stasis, development gallstone disease.
• Skin: rashes, pigmentation, alopecia.
• Neurology: headaches, psychoemotional instability, depression, migraines.
• Metabolism: a sharp increase in weight without changing the diet, edema as a result of fluid retention, an increase in blood glucose, an increase in triglycerides in the blood.
• Sense organs: discomfort in the eyes, hearing impairment.

Rarely occurring side effects from "Lindinet 20" and drug analogues:

• Thromboembolic damage to the veins and the circulatory system, including the brain.
• Lesion of the veins of the lower extremities.
• Complication of lupus erythematosus.

Extremely exceptional violations:

• Damage to the artery of the kidneys and liver.
• Retinal lesion.

Cancellation of the drug is indicated in case of the following disorders:

• A steady rise in blood pressure.
• Porphyria progression.
• Blockage of blood vessels with blood clots.
• Hearing loss associated with otosclerosis.

Strengthening the symptoms of one of the above diseases during the use of hormones requires urgent discontinuation of the drug and the use of non-hormonal contraception.

Special instructions before using oral contraceptives

During pregnancy and lactation, the described remedy is strictly contraindicated. Therefore, some time before the start of admission, it is better to do a pregnancy test or donate blood for hCG. Reason: In the first months of pregnancy, sluggish menstruation is possible.

Before using Lindinet 20, it is important to collect all the required information about the patient's health status and the immediate family members. During the reception of "Lindinet 20" and analogues in the reviews and instructions it is said that every six months it is necessary to undergo a medical examination, as well as a gynecological examination in order to timely determine possible risk factors.

Since a persistent contraceptive effect from the pills is achieved two weeks after the start of use, doctors recommend adopting additional non-hormonal methods these days to protect against pregnancy. The use of hormonal contraceptives is individual in each case.

Before starting, it is important to evaluate all the possible advantages and disadvantages of using the drug, after consulting internally with the attending gynecologist. Before starting taking medications, it is important to consider that the relationship between the use of oral hormonal contraceptives and the occurrence of thrombosis has been scientifically confirmed.

The risk of developing thromboembolic lesions is due to provoking factors:

• mature age of the patient;
• long-term smoking;
• heredity;
• hypertension;
• diabetes;
• prolonged immobility of the patient.

The postpartum period significantly increases the risk of thromboembolism. Unfortunately, there is information about the increased incidence of cervical cancer in the case of prolonged use of hormonal contraceptives. Nevertheless, research data contradict each other, since there are many conditions for the development of cervical cancer, and the effect of oral contraceptives will not necessarily be dominant. It is also known that regular use of oral contraceptives can cause the development of breast cancer.

Taking "Lindinet 20" and analogs in composition, it is important to remember that the drug is not able to protect against HIV infection and other types of sexually transmitted diseases. Condom - the best way protection from infection.

The effectiveness of a hormonal contraceptive can be reduced if:

• skipping pills;
• vomiting;
• repeated diarrhea;
• a long period of time between taking pills;
• the use of drugs that reduce the effect of contraceptives.

After a long time after taking "Lindinet 20", the effectiveness of the drug may decrease. If non-cyclic bleeding of unknown origin appears and does not stop until the end of the blister, then it is necessary to stop taking the drug and not resume until pregnancy is ruled out at the gynecologist's appointment.

The estrogens contained in "Lindinet 20" are able to influence the indices of laboratory studies of organs such as kidneys and liver, thyroid, adrenal glands. Viral liver damage postpones taking the drug for six months.

Smoking while taking the Lindinet 20 contraceptive pills and analogues increases the appearance of possible vascular diseases, which is extremely dangerous for patients over 35 years old. There is no research data regarding the safety of reception while driving and other activities that require increased concentration and speed.

Hormone overdose

There are no known cases of serious side effects from a significant increase in the daily dosage of oral contraceptives. In isolated cases, situations are possible when nausea or vomiting occurs. Young girls may have minor vaginal bleeding. However, exceeding the dosage of the drug is a reason for an urgent visit to the doctor to inform him about it.

Interaction with other drugs

The semi-synthetic antibiotic "Rifampicin" reduces the contraceptive effect and increases the occurrence of breakthrough bleeding, as well as provokes menstrual irregularities. "Carbamazepine" and "Primidone" also reduce the effect of the drug "Lindinet 20". In this regard, for the period of therapy with these drugs, it is necessary to use additional measures to protect against pregnancy.

Laxatives reduce the level of hormones in the blood. "Fluconazole" increases the level of ethinyl estradiol in the patient's blood. Antibiotics of the tetracycline series reduce the level of estradiol in the blood. St. John's wort and preparations based on it cannot be combined with the use of oral contraceptives.

Storage conditions

According to the assurances of manufacturers, "Lindinet 20" is fit for use within three years from the date of production, which is indicated on the carton of the drug. After the expiration date use drug and its analogues are strictly prohibited. If the day is not specified, the expiration date is the last day of the marked month.

Correct storage of medicines:

• do not allow direct sunlight and moisture to come into contact with medicines and even packaging;
• keep out of the reach of children;
• the optimal storage temperature should not be less than 15 degrees and not exceed 25 degrees.

Disposal of tablets

To be able to properly dispose of medicines, you can consult a pharmacist. This knowledge will help protect the environment.

Judging by the reviews, the rating of analogues and "Lindinet 20" is quite high, the last remedy takes a leading position due to its low price. The average cost of Lindinet 20 tablets, from customer reviews, varies greatly across the country and depends on the region. For example, in Moscow for a pack of 21 tablets, prices vary from 450 to 570 rubles. For a package containing three blisters (63 tablets), you will have to pay from 960 to 1220 rubles.

Having analyzed the pharmaceutical market, one can come to the conclusion that Lindinet 20 is cheaper than its analogues. For example, the average cost of a Logest package, where there are 21 tablets, is as much as 740 rubles.

Which not only prevent unwanted pregnancy, but also have a pronounced healing property for gynecological diseases. One of these drugs is Lindinet 20 and 30 ... In this article, we will acquaint you with the instructions, the method of administration and other important points regarding these contraceptive pills.

How to use Lindinet, a brief overview of the instructions

Drink pills 1 time a day for 21 days... You need to drink it at the same time of day. daily.

For example, you drank the first pill at 09:00, which means that all subsequent days you take the tablets at 09:00.

When all the tablets (21 pieces) have been drunk, arrange a seven-day break, during which bleeding should occur.

Then, on the same day of the month when the first pill was taken (for example, on the 18th of January), the use of the drug resumes again (on the 18th of February). And so every month.

The first contraceptive pill must be taken from the 1st to the 5th day of your period.

In the case when there is a transition from one oral contraceptive (combined type) to Lindinet, the very first pill is drunk immediately on secondthe day after the end of taking the previous contraceptive.

After abortion, held in the 1st trimester of pregnancy, Lindenet should be started on the second day or on the day after the operation. There is no need to resort to auxiliary methods of protection.

But after an abortion done in the 2nd trimester, as well as after childbirth, the use of pills can be started no earlier than 21-28 days.

In this case, additional methods of contraception will be required in the first 7 days.

What is the difference between Lindinet 20 and Lindinet 30?

Which pills are right for you, can only be prescribed by a doctor, based on tests.

Lindinet 20 is more designed for young nulliparous girls. The content of hormones in it is less than in Lindinet 30 tablets.

If you do not take into account the characteristics of the body of each particular woman, then if you are 20 years old, most likely the doctor will prescribe Lindinet 20, and accordingly after 30 years, he will write Lindinet 30.

Features of taking Lindinet 20 and Lindinet 30 tablets

When taking birth control pills Lindinet form 20 or 30, it should be borne in mind that if drugs such as ampicillin, tetracycline, felbamate, fluconazole are used, then the activity of the contraceptive decreases.

Therefore, if you drink Lindinet with these medications, take care of additional contraceptive measures, for example, based on spermicides, or any of the barrier methods.

Also, St. John's wort tea lowers the level of Lindenet in the blood and can cause pregnancy or intermediate bleeding.

Therefore, in the case of taking Lindenet 20 or Lindenet 30 in conjunction with other drugs, you need to consult a doctor and make sure that they do not affect the decrease in the active substance of the contraceptive pill.

It should be noted that the drug should not be taken during pregnancy, diabetes mellitus, lactation, venous insufficiency, for any disorders associated with the kidneys and liver.

Side effects from taking Lindinet

The individual characteristics of each woman impose their own side effects from taking Lindinet. In the event of one or more of the side effects listed below, the drug should be discontinued.

These side effects include:

1. Violation of cardio-vascular system... It manifests itself in the form of arterial hypertension or thromboembolism.

2. Hearing loss.

3. Chorea of \u200b\u200bSindenhem.

4. Candidiasis.

5. Bleeding.

6. Galactorrhea.

7. Nausea and vomiting.

8. Breast enlargement and pain in it.

9. Hepatitis.

10. Rash.

11. Erythema nodosum.

12. Headache.

13. Depression.

14. Weight gain.

15. And other allergic reactions.

If you experience any of the above after taking the Lindinet birth control pill, please notify your doctor immediately.

What if I missed Lindinet's appointment?

If for any reason the Lindinet 20 or 30 pill was missed, you should drink it as soon as possible.

Less than 12 hours

If the interval between taking the pills was no more than 12 hours, the contraceptive property of the drug will not decrease. You do not need to resort to additional contraception.

Subsequent pills should be continued as usual.

More than 12 hours

When the interval between the use of the contraceptive is more than 12 hours, the effectiveness of the contraceptive may decrease.

There is no need to take the missed dose.

But within a week you will need to use additional contraceptives (condoms, suppositories) to avoid pregnancy.

Menstruation when taking Lindinet

Menstruation while taking Lindinet may occur if the cycle of using the contraceptive drug has been violated. But in any case, whether there was a failure in taking the pills or not, it is necessary to consult a gynecologist.

The cause of bleeding during the use of Lindinet may be diseases of the genital tract. Therefore, you should immediately consult a doctor who, having made an examination, will be able to find out the true cause of the bleeding.

Published on this page detailed instructions on the use of hormonal contraceptive Lindineth... Available dosage forms the drug (tablets), as well as its analogues. Information is provided on the side effects that Lindinet can cause, on interactions with other medications. In addition to information about diseases and conditions, for the treatment and prevention of which a drug is prescribed (a contraceptive for contraception), admission algorithms are described in detail, possible dosages for adults, children, the possibility of use during pregnancy and breastfeeding is being specified. Annotation to Lindinet is supplemented with reviews of patients and doctors.

Instructions for use and reception scheme

Assign 1 tablet per day for 21 days, if possible at the same time of day. After taking the last pill from the package, take a 7-day break, during which withdrawal bleeding occurs. The next day after a 7-day break (i.e. 4 weeks after taking the first tablet, on the same day of the week), the drug is resumed.

Taking the first tablet of Lindinet should be started from the 1st to the 5th day of the menstrual cycle.

When switching to taking Lindinet from another combined oral contraceptive, the first Lindinet tablet should be taken after taking the last tablet from the package of another oral hormonal contraceptive, on the first day of withdrawal bleeding.

When switching to Lindinet from drugs containing only progestogen ("mini-pills", injections, implant), when taking "mini-pills", Lindinet can be taken on any day of the cycle; the day after the removal of the implant, when using injections - on the eve of the last injection. In these cases, additional methods of contraception should be used in the first 7 days.

After an abortion in the 1st trimester of pregnancy, you can start taking Lindinet immediately after surgery. In this case, there is no need to use additional methods of contraception.

After childbirth or after an abortion in the 2nd trimester of pregnancy, the drug can be taken on days 21-28. In these cases, additional methods of contraception must be used in the first 7 days. At a later start of taking the drug in the first 7 days, an additional, barrier method of contraception should be used. In the case when sexual intercourse took place before the start of contraception, before starting to take the drug, you should exclude pregnancy or postpone the start of taking until the first menstruation.

If you miss a pill, the missed pill should be taken as soon as possible. If the interval in taking the pills is less than 12 hours, then the contraceptive effect of the drug does not decrease, and in this case there is no need to use an additional method of contraception. The rest of the tablets should be taken at the usual time. If the interval is more than 12 hours, then the contraceptive effect of the drug may decrease. In such cases, you should not replenish the missed dose, continue taking the drug as usual, but in the next 7 days you need to use an additional method of contraception. If there are less than 7 tablets left in the package, you should start taking the drug from the next package without interruption. In this case, withdrawal bleeding does not occur until the completion of taking the drug from the second package, but spotting or breakthrough bleeding may appear.

If withdrawal bleeding does not occur after the completion of taking the drug from the second package, then pregnancy should be excluded before continuing to take the drug.

If vomiting and / or diarrhea begins within 3-4 hours after taking the drug, a decrease in the contraceptive effect is possible. In such cases, you should proceed in accordance with the instructions for skipping pills. If the patient does not want to deviate from the usual contraceptive regimen, the missed pills should be taken from a different package.

To speed up the onset of menstruation, you should reduce the break in taking the drug. The shorter the break, the more likely it is that breakthrough or spotting bleeding will occur while taking the tablets from the next pack (similar to cases with delayed menstruation).

To delay the onset of menstruation, the drug must be continued from a new package without a 7-day break. You can delay your period as long as necessary until the end of the last pill from the second pack. With a delay in menstruation, breakthrough or spotting bleeding may appear. Regular use of Lindinet can be restored after the usual 7-day break.

Release forms

Film-coated tablets.

The difference between Lindinet 20 and Lindinet 30

The main difference between both drugs lies in the different amount of ethinyl estradiol included in the component, one type of drug contains 30 μg, the other 20 μg. Hence the different names for nevertheless similar drugs. Also, both drugs contain 75 μg of gestodene.

Lindineth - monophasic oral contraceptive. Inhibits the secretion of pituitary gonadotropic hormones. The contraceptive effect of the drug is associated with several mechanisms. The estrogenic component of the drug is ethinyl estradiol, a synthetic analogue of the follicular hormone estradiol, which, together with the corpus luteum hormone, participates in the regulation of the menstrual cycle. The gestagenic component is gestodene, a derivative of 19-nortestosterone, superior in strength and selectivity of action not only to the natural hormone of the corpus luteum progesterone, but also to other synthetic gestagens (for example, levonorgestrel). Due to its high activity, gestodene is used in low dosages, in which it does not exhibit androgenic properties and has practically no effect on lipid and carbohydrate metabolism.

Along with the indicated central and peripheral mechanisms that prevent the maturation of an ovum capable of fertilization, the contraceptive effect is due to a decrease in the susceptibility of the endometrium to the blastocyst, as well as an increase in the viscosity of mucus in the cervix, which makes it relatively impassable for sperm. In addition to the contraceptive effect, the drug, when taken regularly, also has a therapeutic effect, normalizing the menstrual cycle and helping to prevent the development of a number of gynecological diseases, incl. tumor nature.

Pharmacokinetics

Gestoden

After oral administration, it is rapidly and completely absorbed from the gastrointestinal tract. Bioavailability is about 99%. Gestodene is biotransformed in the liver. It is excreted only in the form of metabolites, 60% - with urine, 40% - with feces.

Ethinylestradiol

After oral administration, ethinyl estradiol is absorbed quickly and almost completely. Ethinylestradiol is excreted only in the form of metabolites, in a ratio of 2: 3 with urine and bile.

Indications

• contraception.

Contraindications

• the presence of severe and / or multiple risk factors for venous or arterial thrombosis (including complicated lesions of the valvular apparatus of the heart, atrial fibrillation, diseases of the vessels of the brain or coronary arteries, arterial hypertension severe or moderate severity with blood pressure ≥ 160/100 mm Hg);
• the presence or indication of a history of precursors of thrombosis (including transient ischemic attack, angina pectoris);
• migraine with focal neurological symptoms, incl. history;
• venous or arterial thrombosis / thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the leg, embolism pulmonary artery) currently or in anamnesis;
• a history of venous thromboembolism;
• surgical intervention with prolonged immobilization;
• diabetes mellitus (with angiopathy);
• pancreatitis (including in history), accompanied by severe hypertriglyceridemia;
• dyslipidemia;
• severe liver disease, cholestatic jaundice (including during pregnancy), hepatitis, incl. history (before the normalization of functional and laboratory parameters and within 3 months after their normalization);
• jaundice when taking GCS;
• gallstone disease at present or in history;
• gilbert's syndrome, Dubin-Johnson syndrome, Rotor syndrome;
• liver tumors (including a history);
• severe itching, otosclerosis, or its progression during a previous pregnancy or taking GCS;
• hormone dependent malignant neoplasms genitals and mammary glands (including if they are suspected);
• vaginal bleeding of unknown etiology;
• smoking over the age of 35 (more than 15 cigarettes per day);
• pregnancy or suspicion of it;
• lactation period;
• hypersensitivity to drug components.

special instructions

Before starting to use the drug, it is necessary to conduct a general medical (detailed family and personal history, measurement of blood pressure, laboratory research) and gynecological examination (including examination of the mammary glands, pelvic organs, cytological analysis of a cervical smear). A similar examination during the period of taking the drug is carried out regularly, every 6 months.

The drug is a reliable contraceptive: the Pearl index (an indicator of the number of pregnancies occurring during the use of the contraceptive method in 100 women within 1 year), if used correctly, is about 0.05. Due to the fact that the contraceptive effect of the drug from the start of administration is fully manifested by the 14th day, then in the first 2 weeks of taking the drug, it is recommended to additionally use non-hormonal methods of contraception.

In each case, before the appointment of hormonal contraceptives, the advantages or possible negative effects of their use are individually assessed. This issue should be discussed with the patient, who, after receiving necessary information will make the final decision on the preference for hormonal or any other method of contraception.

The health status of a woman must be carefully monitored. If, while taking the drug, any of the following conditions / diseases appears or worsens, you must stop taking the drug and switch to another, non-hormonal method of contraception:

• diseases of the hemostatic system;
• conditions / diseases that predispose to the development of cardiovascular, renal failure;
• epilepsy;
• migraine;
• the risk of developing an estrogen-dependent tumor or estrogen-dependent gynecological diseases;
• diabetes mellitus, not complicated by vascular disorders;
• severe depression (if depression is associated with a violation of tryptophan metabolism, then vitamin B6 can be used for correction);
• sickle cell anemia; in some cases (for example, infections, hypoxia), estrogen-containing drugs for this pathology can provoke thromboembolism;
• the appearance of abnormalities in laboratory tests to assess liver function.

Thromboembolic diseases

Epidemiological studies have shown that there is a link between taking oral hormonal contraceptives and an increased risk of developing arterial and venous thromboembolic diseases (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism). An increased risk of venous thromboembolic diseases has been proven, but it is significantly less than during pregnancy (60 cases per 100 thousand pregnancies). When using oral contraceptives, arterial or venous thromboembolism of hepatic, mesenteric, renal or retinal vessels is very rarely observed.

The risk of arterial or venous thromboembolic disease increases:

• with age;
• when smoking (heavy smoking and age over 35 are risk factors);
• if you have a family history of thromboembolic disease (for example, in a parent, brother or sister). If you suspect a genetic predisposition, it is necessary to consult a specialist before using the drug;
• with obesity (body mass index over 30 kg / m2);
• with dyslipoproteinemia;
• with arterial hypertension;
• in diseases of the heart valves complicated by hemodynamic disorders;
• with atrial fibrillation;
• with diabetes mellitus complicated by vascular lesions;
• with prolonged immobilization, after a large surgical intervention, after surgery on the lower extremities, after a severe injury.

In these cases, it is assumed that the drug should be temporarily discontinued (no later than 4 weeks before surgery, and resume no earlier than 2 weeks after remobilization).

Postpartum women have an increased risk of venous thromboembolic disease.

It should be borne in mind that diabetes mellitus, systemic lupus erythematosus, hemolytic uremic syndrome, Crohn's disease, ulcerative colitis, sickle cell anemia, increase the risk of developing venous thromboembolic diseases.

It should be borne in mind that resistance to activated protein C, hyperhomocysteinemia, protein C and S deficiency, antithrombin 3 deficiency, the presence of antiphospholipid antibodies, increase the risk of developing arterial or venous thromboembolic diseases.

When assessing the benefit / risk ratio of taking the drug, it should be borne in mind that targeted treatment of this condition reduces the risk of thromboembolism. The symptoms of thromboembolism are:

• sudden chest pain that radiates to the left arm;
• sudden shortness of breath;
• any unusually severe headache that persists for a long time or appears for the first time, especially when combined with sudden complete or partial loss of vision or diplopia, aphasia, dizziness, collapse, focal epilepsy, weakness or severe numbness of half of the body, movement disorders, severe one-sided pain in the gastrocnemius muscle, sharp abdomen.

Tumor diseases

Some studies have reported an increased incidence of cervical cancer in women who have taken hormonal contraception for a long time, but research results are conflicting. Sexual behavior, human papillomavirus infection and other factors play a significant role in the development of cervical cancer.

A meta-analysis of 54 epidemiological studies showed that there is a relative increase in breast cancer risk among women taking oral hormonal contraceptives, but higher breast cancer detection rates may have been associated with more regular medical check-ups. Breast cancer is rare among women younger than 40 years old, whether they are taking hormonal contraception or not, and increases with age. Taking pills can be considered one of many risk factors. However, the woman should be made aware of the potential for breast cancer risk based on an assessment of the benefit / risk ratio (protection against ovarian and endometrial cancer).

There are few reports on the development of benign or malignant liver tumors in women taking hormonal contraceptives for a long time. This should be borne in mind in the differential diagnostic assessment of abdominal pain, which may be associated with an increase in liver size or intraperitoneal bleeding.

Chloasma

Chloasma can develop in women with a history of this disease during pregnancy. Those women who are at risk of chloasma should avoid contact with sunlight or ultraviolet radiation while taking Lindinet.

Efficiency

The effectiveness of the drug may decrease in the following cases: missed pills, vomiting and diarrhea, the simultaneous use of other drugs that reduce the effectiveness of contraceptive pills.

If the patient is simultaneously taking another drug that may reduce the effectiveness of birth control pills, additional methods of contraception should be used.

The effectiveness of the drug may decrease if, after several months of their use, irregular, smearing or breakthrough bleeding appears, in such cases it is advisable to continue taking the pills until they end in the next package. If at the end of the second cycle menstrual bleeding does not begin or acyclic spotting does not stop, stop taking the pills and resume it only after excluding pregnancy.

Changes in laboratory parameters

Under the influence of oral contraceptive pills - due to the estrogenic component - the level of some laboratory parameters (functional parameters of the liver, kidneys, adrenal glands, thyroid gland, hemostasis indicators, levels of lipoproteins and transport proteins) may change.

Additional Information

After acute viral hepatitis, the drug should be taken after normalization of liver function (no earlier than 6 months).

With diarrhea or intestinal disorders, vomiting, the contraceptive effect may decrease. Without stopping taking the drug, it is necessary to use additional non-hormonal methods of contraception.

Women who smoke have an increased risk of developing vascular diseases with serious consequences (myocardial infarction, stroke). The risk depends on age (especially in women over 35) and on the number of cigarettes smoked.

A woman should be warned that the drug does not protect against HIV infection (AIDS) and other sexually transmitted diseases.

Influence on the ability to drive vehicles and use mechanisms

No studies have been conducted to study the effect of Lindinet on the ability to drive a car and production mechanisms.

Side effect

Side effects requiring discontinuation of the drug:

• arterial hypertension;
• arterial and venous thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism);
• arterial or venous thromboembolism of the hepatic, mesenteric, renal, retinal arteries and veins;
• hearing loss due to otosclerosis;
• hemolytic uremic syndrome;
• porphyria;
• exacerbation of reactive systemic lupus erythematosus;
• sydenham's chorea (disappearing after drug withdrawal).

Other side effects (less severe):

• acyclic bleeding / spotting from the vagina;
• amenorrhea after drug withdrawal;
• changes in the state of vaginal mucus;
• development of inflammatory processes of the vagina;
• candidiasis;
• tension, pain, enlargement of the mammary glands;
• galactorrhea;
• epigastric pain;
• nausea, vomiting;
• crohn's disease;
• ulcerative colitis;
• the onset or exacerbation of jaundice and / or pruritus associated with cholestasis;
• liver adenoma;
• erythema nodosum;
• exudative erythema;
• rash;
• chloasma;
• increased hair loss;
• headache;
• migraine;
• lability of mood;
• depression;
• hearing loss;
• increased sensitivity of the cornea (when wearing contact lenses);
• fluid retention in the body;
• change (increase) in body weight;
• decreased tolerance to carbohydrates;
• hyperglycemia;
• allergic reactions.

Drug interactions

The contraceptive activity of Lindinet decreases when taken simultaneously with ampicillin, tetracycline, rifampicin, barbiturates, primidone, carbamazepine, phenylbutazone, phenytoin, griseofulvin, topiramate, felbamate, oxcarbazepine. The contraceptive effect of oral contraceptives decreases with the use of these combinations, breakthrough bleeding and menstrual irregularities become more frequent. While taking Lindinet with the above drugs, as well as within 7 days after completing the course of taking them, it is necessary to use additional non-hormonal (condom, spermicidal gels) methods of contraception. When using rifampicin, additional contraceptive methods should be used within 4 weeks after completion of the course.

When used simultaneously with Lindinet, any drug that increases gastrointestinal motility, reduces the absorption of active substances and their level in the blood plasma.

Sulfation of ethinyl estradiol occurs in the intestinal wall. Preparations that also undergo sulfation in the intestinal wall (incl. vitamin C), competitively inhibit the sulfation of ethinyl estradiol and thereby enhance the bioavailability of ethinyl estradiol.

Inducers of microsomal liver enzymes reduce the level of ethinyl estradiol in the blood plasma (rifampicin, barbiturates, phenylbutazone, phenytoin, griseofulvin, topiramate, hydantoin, felbamate, rifabutin, oscarbazepine). Liver enzyme inhibitors (itraconazole, fluconazole) increase the level of ethinyl estradiol in the blood plasma.

Some antibiotics (ampicillin, tetracycline), interfering with the intrahepatic circulation of estrogens, reduce the level of ethinyl estradiol in plasma.

Ethinyl estradiol, by inhibiting liver enzymes or accelerating conjugation (primarily glucuronidation), can affect the metabolism of other drugs (including cyclosporine, theophylline); the concentration of these drugs in blood plasma may increase or decrease.

With the simultaneous use of Lindinet with St. John's wort preparations (including infusion), the concentration of active substances in the blood decreases, which can lead to the appearance of breakthrough bleeding, pregnancy. The reason for this is the inducing effect of St. John's wort on liver enzymes, which continues for 2 more weeks after the completion of the course of taking St. John's wort. It is not recommended to prescribe this combination of drugs.

Ritonavir reduces the AUC of ethinyl estradiol by 41%. In this regard, during the use of ritonavir, a hormonal contraceptive with a higher content of ethinyl estradiol (Lindinet 30) should be used or additional non-hormonal methods of contraception should be used.

It may be necessary to correct the dosage regimen when using hypoglycemic agents, because oral contraceptives can decrease carbohydrate tolerance, increase the need for insulin or oral antidiabetic drugs.

• active substances: gestodene, ethinyl estradiol;
• excipients: sodium calcium edetate, colloidal silicon dioxide, magnesium stearate, corn starch, povidone, lactose monohydrate.

Birth control pills Lindinet: instruction

It is taken orally as a tablet once a day at a specific time for 21 days. After a week's break (withdrawal bleeding occurs), contraception can be continued in taking the pills. The first Lindinet tablet should be taken on the 1-5th day of the menstrual cycle. If you miss a scheduled pill, you must take it as soon as possible.

Lindinet-20 and Lindinet-30

Lindinet-20 (microdissed) and Lindinet-30 (low-dose) differ in the amount of the ethylestradiol component, the dosage of gestodene (75 μg) in both preparations is the same.

Indications for use:

• hormonal contraception;
• treatment of dyshormonal disorders, uterine bleeding, anovulatory menstrual cycles;
• correction and prevention of hyperplastic processes in the reproductive organs.

Contraindications:

• individual intolerance to the components of the drug;
• a history of arterial / venous thrombosis;
• atrial fibrillation, coronary artery / cerebrovascular disease;
• severe uncontrolled arterial hypertension;
• migraine, stroke, myocardial infarction;
• family history of venous thromboembolism;
• prolonged immobilization, diabetes mellitus with signs of angiopathy;
• cholestatic jaundice, pancreatitis, dyslipidemia;
• liver disease, cholelithiasis;
• otosclerosis, hormone-dependent neoplasms of the mammary glands / genitals;
• vaginal bleeding of unexplained etiology;
• lactation, pregnancy.

Risk factors:

• age over 35-40 years old, thrombosis, smoking;
• hemolytic uremic syndrome, obesity;
• severe trauma, thrombophlebitis, repeated depressive episode;
• ulcerative colitis, Crohn's disease, systemic lupus erythematosus.

Oral contraceptives Lindinet: side effects

• porphyria, blood pressure surges, short-term hearing loss;
• hemolytic uremic syndrome;
• vein thrombosis of the lower extremities, Sydenham's chorea;
• acyclic bleeding, amenorrhea as a result of drug withdrawal;
• candidiasis, change in libido;
• galactorrhea, pain in the mammary glands;
• diarrhea, lower abdominal pain, nausea;
• medicinal hepatitis, ulcerative colitis, cholelithiasis;
• hair loss, erythema, rash;
• depressive episodes, migraines, headaches, dizziness;
• changes in body weight, fluid retention, decreased susceptibility to carbohydrates;
• allergic reactions.

Overdose:

Serious cases of overdose have not been recorded, vomiting, nausea, mild vaginal bleeding are possible. There is no specific antidote, symptomatic therapy is indicated.

Contraceptive Lindinet: reviews and drugs similar in action

Lindinet is one of the best modern oral contraceptives, more than 50% of women who need contraceptives prefer Lindinet. The drug reliably prevents conception, regulates the menstrual cycle, several times reduces the risk of malignant tumors endometrium and ovaries. Contraceptives similar in action:,.

Positive reviews:

• reduces the frequency of functional uterine bleeding;
• reduces the risk of mastopathy formation;
• provides a minimum of hormonal load on the body;
• does not cause complications, is easily tolerated;
• softens the manifestations of premenstrual syndrome, regenerates the endometrium.

Negative reviews:

• does not protect against HIV infection and sexually transmitted diseases.

Lindinet: reviews of doctors

Experts note the high contraceptive reliability of Lindinet 20/30 (Pearl index 0.05). The use of contraceptive pills Lindinet provides prevention of unplanned pregnancy, correction of the menstrual cycle, restores the balance of sex hormones. The drug has a minimum of side reactions / complications and a number of protective / medicinal properties. Recommended by gynecologists as a reliable oral contraceptive for all categories of women, including the somatically burdened contingent.

Composition Lindinet 20 (1 tablet):

• - 0.02 mg;
• - 0.075 mg;
• magnesium stearate - 0.2 mg;
• povidone - 1.7 mg;
• corn starch - 15.5 mg;

Composition Lindinet 30 (1 tablet):

• ethinylestradiol - 0.03 mg;
• gestodene - 0.075 mg;
• sodium calcium edetate - 0.065 mg;
• magnesium stearate - 0.2 mg;
• colloidal silicon dioxide - 0.275 mg;
• povidone - 1.7 mg;
• corn starch - 15.5 mg;
• lactose monohydrate - 37.165 mg.

Both pharmaceutical forms are supplied in the form of tablets, the shell of which has the following components:

• sucrose - 19.66 mg;
• - 8.231 mg;
• macrogol 6000 - 2.23 mg;
• titanium dioxide - 0.46465 mg;
• povidone - 0.171 mg;
• yellow quinoline dye (D + C yellow No. 10 - E 104) - 0.00135 mg.

Release form

In pharmacy kiosks, the drug is presented in the form of round, biconvex tablets, which are coated with a light yellow color on both sides. There are no inscriptions or designations. At a break, a tablet is white or close to white with a light yellow edging of the shell.

pharmachologic effect

Lindinet belongs to the group of monophasic combined oral administration based on sex hormones , respectively, it is used mainly for contraceptive purposes. Main therapeutic effect the drug is associated with several mechanisms of action at once, including a decrease in the secretion of gonadotropic hormones , active obstruction of ovulatory processes and inhibition of the maturation of follicles in the ovaries.

First of all, it should be noted that ethinyl estradiol , one of the biologically active constituents, is a synthetic analogue of follicular hormone , which, together with the hormones of the corpus luteum, participates in the regulation of a woman's menstrual cycle, significantly inhibiting it at certain stages.

Another active ingredient is gestodene is a gestagenic 19-nortestosterone derivative and is a stronger and more selective version of natural secreted by the corpus luteum. This component is used in ultra low amounts, due to which it does not realize its androgenic potential (the chemical basis for gestodene is a variation of the male sex hormone) and affects the carbohydrate and lipid metabolism of the body to the least extent.

In addition to the central mechanisms of action directly on sex hormones, the drug implements contraceptive properties indirectly through peripheral components. Under the influence of a pharmaceutical preparation, susceptibility decreases to the blastocyst, which makes the process of implantation of the initial forms of the fetus almost impossible. Also, the density and viscosity of mucus localized in the cervix increases, which becomes largely impassable for sperm, making active movements towards the female ovum.

Lindinet has not only contraceptive effects, the pharmaceutical product contributes to active prevention some gynecological diseases and not only. In particular, the possibility of the appearance of functional ovarian cysts and ... Reduces the risk of in the mammary glands, stagnant inflammatory processes practically come to naught. The beneficial properties of the medicinal product extend to skin as their general state and the degree of manifestation decreases (with regular use, dermatological defects disappear completely).

Pharmacodynamics and pharmacokinetics

Pharmacokinetic abilities of gestodene

After oral administration fairly quickly and almost completely the active component is absorbed from the gastrointestinal tract, because its bioavailability is about 99%, and the maximum concentration of 2-4 ng / ml is noted after 1 hour.

In the bloodstream gestodene contacts and specific globulin SHBG , only 1-2% of the amount of the active ingredient remains in free form. The pharmacokinetics of gestodene largely depends on the level of SHBG and the concentration of estradiol, because the amount of the selective carrier increases by 3 times under the action of the sex hormone. The constant intake of oral contraceptives also contributes to the active saturation of gestodene, with its daily use, the concentration increases by 3-4 times.

The main stages of biochemical transformation, the active component undergoes in the liver, after which it is excreted in the urine (60%) and feces (40%) only in the form of metabolites. The half-life of the active ingredient is two-phase and takes about 1 day, since the average plasma clearance is from 0.8 to 1 ml / mln / kg.

Pharmacokinetic abilities of ethinyl estradiol

The second active component has slightly lower absorption rates - due to presystemic conjugation and primary metabolism, the absolute bioavailability of the pharmacological component from the digestive tube is only 60%, and the maximum concentration of 30-80 pg / ml is achieved in 1-2 hours.

From the side of distribution, ethinyl estradiol, on the contrary, outperforms gestodene, because 98.5% of the active substance binds to nonspecific albumin. Also, the active component induces an increase in the level of SHBG, which has a beneficial effect on the overall effectiveness of the oral contraceptive. A constant average level of ethinyl estradiol is established by 3-4 days after the start of the therapeutic course, and it is 20% higher than after a single dose of Lindinet's pill.

Biotransformation of the active substance occurs in the liver and is aromatic hydroxylation with the formation of methylated and hydroxylated metabolic products in free form or in the form of conjugates with sulfates or glucuronides. The metabolic clearance from blood plasma ranges from 5-13 ml.

Ethinyl estradiol is excreted only in the form of metabolic products with urine and bile in a ratio of 2: 3. The half-life, like that of gestodene, is biphasic and is about 1 day.

Indications for use

• contraception;
• functional disorders of the menstrual cycle.

Contraindications

• individual hypersensitivity to a pharmaceutical preparation or its constituent components;
• risk factors for arterial or venous thrombosis;
• moderate and severe;
• or as precursors of thrombosis;
• surgical intervention with prolonged immobilization;
• with a pronounced increase in blood triglycerides;
• dyslipidemia ;
• severe liver disease ( hepatitis , cholestatic jaundice and etc);
• , Dubin-Johnson, Rotor;
• neoplasm localized in the liver;
• otosclerosis or a history of a previous pregnancy or after taking glucocorticosteroids;
• smoking over the age of 35;
• hormone-dependent malignant tumors genitals and mammary glands;
• vaginal bleeding of unknown origin;
• the period of lactation and bearing of the child.

Side effects

Adverse effects of treatment requiring immediate cancellation pharmaceutical therapy:

• From the side of cardio-vascular system: arterial hypertension, , , deep vein thrombosis of the lower extremities, , venous or arterial thromboembolism hepatic, mesenteric, retinal or renal vessels.
• From the side sense organs: hearing loss due to otosclerosis .
• Others: porphyria , hemolytic uremic syndrome, exacerbation of reactive , sydenham's chorea .

Side effects, after the appearance of which the expediency of further use of the drug is decided in individual order:

• From the side reproductive system: acyclic vaginal bleeding of unknown etiology, , colpocytological changes in vaginal mucus, inflammatory diseases, , pain, breast enlargement, galactorrhea .
• From the side central nervous system: hearing loss, , , mood lability.
• Dermatological reactions: or exudative erythema , incomprehensible rash, chloasma, increased .
• From the side digestive system : epigastric pain, nausea and vomiting, crohn's disease , nonspecific ulcerative , jaundice and itching that is caused by it, cholelithiasis , liver adenoma, hepatitis.
• From the side metabolic processes: fluid retention in the body, decreased tolerance to carbohydrates, increased triglyceride or blood glucose levels, increased body weight.
• Other allergic reactions.

Instructions for use of Lindinet (Way and dosage)

Lindinet 20, instructions for use

The contraceptive pill is used orally once a day without chewing and drinking plenty of water, regardless of food intake. If possible, you should take the pills at the same time of the day for 21 days, then you need to take a break for 7 days, and then resume using contraceptives. That is, the next pill should be used 4 weeks after the start of the course on the same day of the week. During the break will be observed uterine bleeding, which corresponds to menstruation in the normal cycle.

A course of conservative contraception should be started from the 1st to the 5th day of the menstrual cycle, if no other oral contraceptive has been used before. Otherwise, the 1st tablet must be taken after taking the last dose of the previous pharmaceutical preparation containing hormones, on the 1st day of bleeding after withdrawal.

Transition from progestogen-containing agents on Lindinet requires an additional method of contraception in the first week. The date of the first intake of a new contraceptive must be consistent with the pharmaceutical form of the previous drug:

• in the form of mini-tablets - on any day of the menstrual cycle;
• in case of injections - on the eve of the last injection;
• implant - the next day after its removal.

Lindinet 30, instructions for use

Since this pharmaceutical form is an enhanced version of Lindinet 20 with a higher concentration of ethinyl estradiol, it is recommended to prescribe it after abortion , so that the restoration of the physiological hormonal background was much faster and less painful.

If the abortion was performed in 1st trimester of pregnancy then there is nothing to worry about. Taking oral contraceptives can be started immediately after gynecological manipulations and there is no need to use additional methods of contraception.

If the abortion or childbirth occurred during 2nd trimester of pregnancy , then taking the pharmaceutical preparation can be started only on the 21-28th day after the obstetric operation. At a later start of the course of conservative protection in the first week, a barrier method of contraception should be used. If a full sexual intercourse took place before the start of taking the drug, then before taking contraceptives, you must make sure that there is no new pregnancy.

Oral contraceptive pill skipping

If the next pill intake was missed, then the missing amount of the pharmaceutical preparation in the bloodstream must be replenished as soon as possible. With a delay that duration does not exceed 12 hours , the clinical effects of the contraceptive are not diminished and the need for additional protection by other methods of contraception by itself disappears. Subsequent pills are taken according to the usual schedule.

If a woman missed a pill and did not make up for her loss within 12 hours , then the pharmacological effectiveness of the drug decreases, which requires special measures and precautions. First of all, as soon as possible, you should resume taking the drug and continue to carry it out as usual. For a week after the pass, it is recommended to use any other methods of contraception.

This situation can become more complicated if there are less than 7 tablets left in the package with pills ... How to take in this case - start the next pack without observing the required weekly break, which is carried out only at the end of the 2nd package with contraceptives. It should be noted that during the use of the 2nd pack, spotting or even breakthrough bleeding can be observed, which can indirectly indicate the presence of pregnancy. If hemorrhages have not stopped at the end of the 2nd package, then before continuing to take contraceptives, you should consult a doctor and exclude the presence of a developing fetus in the womb.

Overdose

Taking an excess amount of contraceptive comes with the following symptoms:

• nausea;
• vomiting;
• vaginal bleeding in small amounts.

Specific pharmaceutical antidote for medicinal product no, therefore symptomatic therapy of individual clinical manifestations intoxication.

Interaction

The contraceptive properties of a pharmaceutical product are reduced when used with drugs such as , , , barbiturates, Primidon , , Phenylbutazone , Phenytoin , , Oxcarbazepine .

Therefore, if it is necessary to jointly use these drugs with Lindinet, it is necessary to use additional non-hormonal contraceptives for 7 days (it is recommended to visit an additional consultation with the attending physician and clarify the period for certain). It is also possible the appearance of spotting or bursting bleeding, menstrual irregularities, or some other side effects.

In conditions increased peristalsis or diarrhea the time spent by the contraceptive drug in the lumen of the gastrointestinal tract is reduced, which significantly reduces the absorption properties of the hormonal contraceptive. Any drug that shortens the presence of Lindinet in the digestive tube leads to a decrease in the concentration of active components in the blood, and, accordingly, to a decrease in their beneficial effect.

Drug interactions at the suction stage are modeled on the combined use of a contraceptive with, since biologically active substances are equally subjected to sulfation in the intestinal wall, which inhibits metabolic chains and increases the bioavailability of ethinyl estradiol.

Terms of sale

The purchase of a medicinal product is allowed only with a prescription form.

Storage conditions

It is necessary to save the pharmaceutical preparation in a dry place protected from direct sunlight, out of the reach of young children at a temperature not exceeding 25 degrees Celsius.

Shelf life

special instructions

Pregnancy after using hormonal contraceptives

Oral hormonal contraceptives are a group of pharmaceuticals based on synthetic analogs of female sex hormones (estrogen and progesterone) that prevent ovulation from occurring, preventing the very possibility of fertilization. Of course, a large audience of women is convinced that it is harmful to use them for contraception, since a normal, physiological pregnancy will most likely not occur after a drug change in hormonal levels. However, this is one of the myths about this group of drugs.

After stopping the use of hormonal contraceptives and at the end of the course of conservative contraception, the effects of the drugs gradually fade away. The only feature is that for planning pregnancy you should find out the exact timing of the optimal time for fertilization in the antenatal clinic or from your personal gynecologist. After all, every time a woman takes a pill for a headache, she does not worry about the health of a child that has not yet been conceived, in this case the situation is almost identical.

When you can not use barrier methods of contraception

Lindinet belongs to a reliable hormonal contraceptive drug, which can be learned from a special indicator of the number of pregnancies that occurred during the course of oral contraception in 100 women within 1 year. For this pharmaceutical product, it is only 0.05 if you use the contraceptive correctly and only according to the scheme of use. However, the pharmacological effects of Lindinet do not develop immediately to the full extent, but only by 14 days from the start of taking the pills, because in the first 2 weeks it is recommended to use barrier methods of contraception.

Lindinet 20 and Lindinet 30 - what's the difference?

A large number of visitors to pharmaceutical forums for women are asked the following series of questions: "Lindinet 20 and 30 - what is the difference?", As well as are medicines interchangeable and, finally, what is the best of the two forms of contraceptive drug. The difference in the forms of the same contraceptive lies in concentration one of the active ingredients is ethinylestradiol. In oral tablets, its level can be 0.02 mg and 0.03 mg, respectively, which, in biochemical terms, really classifies them into different categories.

Lindinet 20 has a milder pharmacological effect and, to a lesser extent, promotes an increase in the selective SHBG transporter, which makes it possible to use it for contraception, however for therapeutic needs , as a rule, a stronger form of the drug is required, therefore Lindinet 30 is used. What differs from weaker tablets in a more concentrated form of the drug is not advertised, since sometimes, according to individual indications, even as a contraceptive, it is necessary to use Lindinet 30, which may be perceived by a woman as an unfair load of hormonal drugs.

It is categorically contraindicated to independently replace the pharmaceutical forms of the drug, because a qualified specialist who prescribes contraceptives or therapeutic agents relies on the results clinical research, their interpretation and many years of experience in their field, and not on a rough idea of \u200b\u200bthe biomechanism of the female body. If you experience any side effects or other adverse effects, you should seek advice and resolve this issue on an individual basis.

Since Lindinet is produced in Hungary, its cost in pharmacy kiosks is much lower than that of a drug released jointly by French and German pharmacists, but this in no way speaks of the effectiveness of the former, therefore the choice of a contraceptive should be entrusted to qualified specialist, because it is based on individual indicators of hormonal balance and some other medical aspects.

Which is better: Novinet or Lindinet 20?

Novinet - a monophasic oral contraceptive, which, in addition to ethinyl estradiol, contains a synthetic progestogen , which slightly changes the mechanism of action of the contraceptive drug. Like all artificial pharmaceutical ingredients of this nature, desogestrel has a high affinity for progesterone receptors located in the hypothalamic-pituitary region, on which its effects are based. In sufficiently small quantities, it is able to "turn on" the mechanism of negative feedback, resulting in a sharp inhibition of the release and production of gonadotropins and a complete blocking of ovulation.

Since Novinet includes such a potent pharmaceutical component as one of the active substances, its price is therefore almost twice as high as that of Lindinet. However, with certain individual indications or contraindications, a woman does not have the opportunity to use a cheaper contraceptive, which makes it possible to include Novinet in a conservative contraceptive course.

Alcohol and Lindinet

Biochemical studies have shown that small amounts of alcohol do not affect the effectiveness of oral contraception. Moderate dosages of alcoholic beverages are considered up to 3 glasses of wine or 50 grams of cognac, but no more, since an increase in the amount of alcohol in the blood increases the risk of possible pregnancy.