Ciprinol is an instruction on the use of tablets and p-ra for infusions. Tsiprinol Tablets - Instructions for the use of Ciprinol from what helps

Cyprinol ® is an antibacterial drug CP-W wide spectrum Actions from the fluoroquinolone group (monofluorinated fluoroquinolone IIth generation).

Active active substance-. It has a powerful bactericidal effect, implemented due to the inhibition of bacterial topoisomerase and DNA giraz. This leads to a violation of stability. bacterial cell And her death.

Ciprofloxacin resistance in bacteria is rarely produced.

When admitting inside the active substance is quickly absorbed from the digestive organs. Food slightly slows down suction. Ciprinol ® bioavailability exceeds 80%. Cmax is achieved on average after 70-80 minutes. Bonding with blood plasma proteins is 30 percent.

Ciprinol ® is distributed in tissue respiratory tract, digestive organs, spinal, seed and synovial (fills the bay of joints) fluid, fatty tissue , inflammatory exudate and horror. The antibiotic acts at the cellular level: penetrates neutrophilic granulocytes and mononuclear phagocytes.

This property helps in the fight against alien agents localized inside the cells. The concentration of drugs in polymorphonuclear blood leukocytes is two to seven times higher than in plasma. Metabolization occurs in the liver. Tsiprinol penetrates the placenta and in maternal milk. Pharmacokinetic data for children is limited.

Cyprinol ® is it still an antibiotic or not?

Tsiprinol ® is an antibiotic: it refers to a group of fluoroquinolones (quinolones), which have pronounced antibacterial activity and a wide range of action. They are widely used in medical practice Since the middle of the last century, as an LAN wide spectrum of action.

The first drugs of the quinolone row became nodium acid, synthesized in the sixties. In its pharmacokinetic properties, it is inferior to many modern drugs. The present breakthrough in medicine was the preparation of new effective compounds containing a fluorine atom (F), which were called "fluoroquinolones".

What do Ciprinol ® tablets help?

Ciprinol ® stops infection that has been provoked by microorganisms sensitive to it. These include:

• gram-positive aerobes:bacillus of Siberian ulcers, enterococcus fecal, staphylococci;
• gram negative aerobes:hydrophilic aeromonads, Brucella, tsitrobakter, frantsiselly, wand Dyukreya, Haemophilus influenzae, Legionella, Moraxella catarrhalis, meningococcus, Pasteurella multotsida, Salmonella, Shigella, vibrio, Yersinia pestis, akinetobakteriya Bauman, Burkholder, campylobacter, tsitrobakter Freund, Enterobacter aerogenes, Enterobacter cloaca Intestinal wand, Chlebseyella Oxitok, Klebsiella Pneumonia, Morgana Bacteria, Gonokokk, Act Miracybbles, Vulgar Protea, Sinygnaya Wand, Fluorescent Pseudomonad, Sergey Margescence.

Cyprinol ® resistance ® is characteristic of some anaerobam, mycoplasmas, chlamydias, simplest etc.

Composition of Ciprinol ® and dosage

Ciprinol ® is produced in the form of tablets (in one package of 10 pieces and instructions for use) coated with a film shell (250 mg, 500 mg and 750 mg); Yellowish-green mortar for infusion therapy and concentrate (in ampoules).

Cyprinol ® contains in its composition the active substance of ciprofloxacin hydrochloride monohydrate and auxiliary components.

Name of the disease	Dose	A course of treatment
Bacteridation of typhoid bacteria	250 milligrams. Two reception. There may be an increase in dose to 500-750 mg. The duration of treatment is up to the month.	Up to the month
Diarrhea travelers	On 500 every 12 hours. From five to seven days.	Up to two weeks
Infectious lesions of ENT organs	On 500 every 12 hours. In severe cases of 750 milligrams	-
Digestive Organs Provided by Golden Staphylococcus	750 milligrams. Interval between acceptors - 12 hours	From week to month
Infectilation of the respiratory system	250-750 milligrams. Two reception. Duration of treatment Dosage depends from the severity of the flow of infection	-
Treatment and prevention of malignant carbuncule	On 500 every 12m milligrams. At the beginning of therapy use parenteral administration. The duration of treatment is 60 days.	Two month
Kidney and urinary infection	250-500 mg every 12 hours	Three days
		From seven to ten days
Acute gonorrhea	One-time reception in a dose of 250-500 milligrams	-
Gonorrhea, combined with chlamydial whether by mycoplasma infection	750 milligrams. The interval between acceptances is 12 hours. Duration of treatment - from 7 to 10 days	From seven to ten days
Complications caused by a blue chopstick in children with cystic fibrosis of lungs	20 mg per kg body weight twice a day (Maximum up to 1.5 grams per day). The duration of treatment from 10 to 14 days.	To crescent
Prevention surgical infections	500 milligrams 60 minutes before surgery	-
Peritonitis	750 milligram twice a day, parenterally, with a transition to oral administration after improving the patient's condition.	Up to sixty days
Chronic inflammation of the prostate gland	500 milligrams twice a day. Up to 28 days.	Four weeks
Chancroid	500 mg every 12 hours.	Several days

* (x2) - twice a day

The duration of treatment is determined by the severity of the disease. Tsiprinol ® take another three day after the disappearance of symptoms, which contributes to securing therapeutic effect. In case of insufficiency of liver functions, the standard daily dose is reduced by half.

Indications for the use of medication

Infections, the pathogens of which are sensitive to the antibiotic pathogens:

• respiratory tract:pneumonia, acute and chronic bronchitis, purulent bronchiectases (provoked by gram-microorganisms, especially a silicular wand in patients with cystic cycidosis);
• LOR organs:pharyngitis, tonsillitis, otitis, mastoid, sinusitis;
• urinary system:uncomplicated and complicated infections urinary tract;
• reproductive system and small pelvis organs:epididiment, prostatitis, inflammation of phallopy pipes, adnexitis, endometritis, ovarian inflammation and pelvic peritonitis, gonorrhea, chalkroid;
• abdominal infections: acute peritonitis, cholecystitis;
• diarrhea of \u200b\u200bbacterial etiology: Salmonellosis, Iraciniosis, Enterite, caused by Irancoliki, Schigellia, Abdominal Tiff, Travel diarrhea;
• skin Pokrov and non-epithelial outcommodes: infected wounds, climbing, outdoor otitis, post-traumatic wound infections);
• muscular system:purulent bone damage, infectious arthritis;
• prevention and therapy of the carbuncule of malignant (Siberian ulcer);
• prof. and therapy of infections in patients with reduced immunity against the background of treatment with immunosuppressive drugs.

Contraindications

Ciprinol ® is not prescribed in children's and adolescence (up to 18 years). The exception is the treatment and prevention of Siberian ulcers and cinema pulmonary infections in patients with fibrosis.

Antibiotic contraindicated in the following cases:

• pregnancy breastfeeding;
• pseudomambranous colitis;
• hypersensitivity to ciprofloxacin;
• m-6-FDG insufficiency;
• simultaneous reception with some Miorlaxants central action leads to a significant decrease in blood pressure;
• kidney dysfunction.

Experts with caution prescribe Cyprinol ® patients of old age, epilepticam, persons suffering from mental disorders, as well as patients with stroke stroke, patients with a violation of cerebral circulation.

Treatment should be under the supervision of a doctor in the presence of generalized convulsion, liver failure, atherosclerosis of the brain vessels, lesions of the incoming soft tissues, ventricular tachycardia, the syndrome of congenital elongation of the Qt interval, Miasthenia, the pathology of sinus rhythm, violations of water - electrolyte balance (with reduced concentration of potassium and magnesium ions in the blood).

Medicinal interaction

Concerning medicinal interactionThe danger represent combinations with the following pharmacological groups:

Name	How does the interlets interaction manifest
Antacid preparations, as well as medicines containing ions Zincum, Aluminum, Ferrum	Suctionability decreases (the interval between acceptors should be at least four hours)
Didanosin ® (HIV infection treatment	Reduces antibiotic absorption
Metoklopramid ® (blocker dopamine receptors and serotonin receptors)	CMAX achievements is reduced
Non-steroidal anti-inflammatory agents / agents and aspirin	Risk of spasms increases
Dicumarine ®, Warfarin ®, Neodyacumarine ® and antidiabetic agents	Lowering prothrombin index
Xanthines	Increased period T1 / 2
Urrikodepressive LS.	Elimination slows down twice
Cyclosporin ® (powerful immunosuppressant)	Risk of nephrotoxicity

This list includes antidepressants, for example, intrivations ®, neuroleptics, for example, Clozapine ® and Olanzaine ®, 1,3-dimethylksanthine, caffeine, requiem modestab ®. Synergism is observed at owls local application with antibiotic drugs, including β-lactams.

Possible side effects

The list of unwanted drug reactions developing against the background of antibiotic therapy includes violations:

• blood I. lymphatic systems: increase in the number of eosinophils, anemia, decrease in blood granulocytes, plastic bone marrow anemia, inhibition of bone marrow functions;
• lymphoid bodies I. immune system: Svet Qink allergic reactions, anaphylaxis;
• exchange processes and nutrition: eating disorders, increase and reduced glucose content;
• mental disorders: strong emotional arousal, anxiety, disorientation, depressive states, hallucinosis, night fears, psychosis;
• nervous system: insomnia, vertigo, numbness, perversion of sensitivity, trembling, ataxia, anosmia, hyperesthesia, elevated intracranial pressure, polyneuropathy;
• feeling organs: color uninhabited, tinnitus, over-oxic hearing loss;
• hearts and vessels: increase the frequency of heart rate, stomatricular Tachycardia, Increase the lumen blood vessels, reduction of blood pressure, arteritis;
• breath organs: the narrowing of the bronchi;
• digestive tract organs: dyspeptic phenomena, increased gas formation, pancreatitis, pseudommbranous colitis;
• hepatobiliary system: an increase in bilirubin concentration, level of liver enzymes;
• skin cover and subcutaneous fabrics: rash, rope fever, improving the sensitivity of the body to the action of ultraviolet radiation, acute epidermal necroliz, bustle examine;
• locomotor system: joint pain, muscle hypertonus, muscular spasmod, decline in force, tendinosis;
• urinary system: the presence of erythrocytes in the urine, salt diathesis;
• reactions at the injection site: Otion, high sweating;
• changes in biochemical blood test indicators: increasing the activity of amylase and many (in individuals who host by Phillaquinone antagonists);
• development of candidiasis.

from 310 to 434 p.

Chapel ®.The pharmaceutical company Lupin Limited ® is produced.

Ciprinol ® analogues are also QIPRobid ® (from 310 to 434 p.)and Ciplox ® (from 310 to 434 p.).

This article allows you to familiarize yourself with the instructions for the use of the drug. Ciprinol. Presented reviews of site visitors - consumers this medicine, as well as the opinions of medical professionals in the use of Ciprinol antibiotic in their practice. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effectsmay not be stated by the manufacturer in annotations. Cyprinol analogues in the presence of available structural analogues. Use for treatment infectious diseases In adults, children, as well as in pregnancy and breastfeeding. The composition and interaction of the drug with alcohol.

Ciprinol - Antimicrobial preparation of a wide range of action from a group of fluoroquinolones. Acts bactericidal. Inhibits the enzyme DNA gyrase bacteria, as a result of which the replication of DNA and the synthesis of cell proteins of bacteria is disturbed. Ciprofloxacin acts on both breeding microorganisms and microorganisms in the rest phase.

The drug is active with respect to gram-negative bacteria: Escherichia coli (intestinal wand), Salmonella SPP. (Salmonella), Shigella SPP. (Shigella), Citrobacter SPP., Klebsiella SPP. (Klebsiella), Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Serratia marcescens, Hafnia alvei, Edwardsiella tarda, Providencia spp., Morganella morganii, Vibrio spp., Yersinia spp., Haemophilus spp., Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromonas spp ., Pasteurella Multocida, Plesiomonas Shigelloides, Campylobacter Jejuni, Neisseria SPP.; Intracellular microorganisms: Legionella Pneumophila (Legionella), Brucella SPP., Chlamydia Trachomatis (Chlamydia), Listeria Monocytogenes, Mycobacterium Tubercterculosis (Mycobacterium), Mycobacterium Kansasii, Mycobacterium Avium-Intracellulare; Gram-positive bacteria: Streptococcus SPP. (including Streptococcus Pyogenes (Streptococcus), Streptococcus Agalactiae), Staphylococcus SPP. (including Staphylococcus Aureus (Staphylococcus), Staphylococcus Haemolyticus, Staphylococcus Hominis, Staphylococcus saprophyticus). Most of staphylococci resistant to meticillin is resistant to ciprofloxacin.

The preparation is moderately sensitive to Streptococcus Pneumoniae, Enterococcus Faecalis.

The drug is resistant to Corynebacterium SPP., Bacteroides Fragilis, Pseudomonas Cepacia, Pseudomonas Maltophila, Ureaplasma urealyticum. (Ureaplasm), Clostridium Difficile, Nocardia Asteroides.

The effect of the drug in relation to Treponema Pallidum (Treplema) is not sufficiently studied.

When taking Ciprinol, there is no development of parallel resistance to other antibiotics that does not belong to the group inhibitors of the gyrase, which makes it highly efficient with respect to bacteria, which are resistant to aminoglycosides, penicillins, cephalosporins, tetracyclines.

Structure

Ciprofloxacin + excipients.

Pharmacokinetics

After taking the drug inside, Cyprinol is quickly absorbed from the gastrointestinal tract. Eating slows down suction, but does not affect bioavailability. Bioavailability varies from 50% to 85%. Ciprofloxacin is well distributed in the tissue and fluid of the body, while high concentrations are installed in bile, lungs, kidneys, liver, bile bubble, uterus, seed liquid, prostate fabric, almonds, endometrials, phallopy tubes and ovaries. The concentration of ciprofloxacin in these tissues is higher than in serum. Ciprofloxacin also penetrates well into the liquid environment of the eyes, in the bone, bronchial secret, saliva, skin, muscles, in the pleura, peritoneum and in lymph. In the spinal fluid penetrates in a small amount, the concentration of ciprofloxacin with unrevented brain shells is 6-10% of those in the blood serum, with inflamed - 14-37%. The concentration of ciprofloxacin in neutrophils is 2-7 times higher than in serum. Penetrates through a placental barrier.

Biotransformed in the liver (15-30%) to form lowact metabolites (diethyl cyprofloxacin, sulfocyploloxacin, oxyciprofloxacin, formylcyprofloxacin). Excreted mainly with urine (50-70%); 15-30% - with feces.

Indications

Infectious-inflammatory diseases caused by microorganisms sensitive to the drug, including:

• respiratory tract: pneumonia (with the exception of pneumococcal pneumonia), acute bronchitis and aggravation of chronic bronchitis, bronchiectatic disease, cystic disease (if the pathogen is gram-negative bacteria, especially Pseudomonas Aeruginosa);
• ear, throat and nose (angina, tonsillitis, sharp middle Otitis, sinusitis, mastoiditis);
• kidneys and urinary tract (uncomplicated and complicated infections of the lower and upper departments of urinary tract (urethritis, cystitis, pyelonephritis));
• organs of the small pelvis and genital organs (epididimitis, prostatitis, salpindigit, endometritis, ooforite, tubular abscess and pelvioperitonitis, gonorrhea, soft chance, chlamydia);
• organs abdominal cavity (intraperic abscess, cholecystitis, cholangitis (in combination with metronidazole or clindamycin));
• infectious diarrhea (salmonellosis, Campylobacteriosis, Iraciniosis, Shigellis, cholera, abdominal typhoid, traveler diarrhea, Salmonella Typhi bacteridation);
• skin and soft tissues (infected ulcers, infected wounds, abscesses, phlegmon, external auditory pass infection, infected burns);
• musculoskeletal system (osteomyelitis, septic arthritis);
• prevention and treatment of the pulmonary form of Siberian ulcers;
• prevention and treatment of infections in patients with reduced immunity (against therapy with immunosuppressants).

Forms of release

Shell tablets 250 mg, 500 mg and 750 mg.

The solution for infusion and concentrate for the preparation of the solution for infusions (injections in ampoules for injections).

Tablets of prolonged action covered with a shell (CPRINOL CP).

Instructions for use and dosage

Dosing mode is set individually, depending on the localization and severity of the flow of infection, the state of the body, age, body weight, the patient's kidney function.

With uncomplicated diseases of the kidneys and urinary tract, the drug is prescribed 250 mg 2 times a day, with complicated - 500-750 mg 2 times a day.

In case of diseases of the lower respiratory tract - 250 mg 2 times a day, in severe cases - 500-750 mg 2 times a day.

In the treatment of gonorrhea, the drug is prescribed once in a dose of 250-500 mg.

In case of enteritis, the colitis of severe flow, gynecological infections, prostatitis, osteomyelitis - 500-750 mg 2 times a day.

For the treatment of diarrhea - 250 mg 2 times a day.

For the prevention of surgical infections - 500-750 mg every other day.

The duration of treatment depends on the severity of the disease.

Tablets should be taken on an empty stomach, drinking sufficient liquid.

maybe intravenous administration drug. The dose of Ciprinol is determined depending on the severity of the disease, the type of infection, the state of the body, age, body weight, the patient's kidney function.

The drug can be administered intravenously inkjet, but more preferably the extravanced drip (in the form of a dropper) introduction for 30 minutes (200 mg) and 60 minutes (400 mg).

Under acute gonor, 100 mg of the drug is introduced once.

For the prevention of postoperative infections - 30-60 minutes before operation, 200-400 mg of ciprinol is introduced.

Tablets prolonged Wed

Assign 1 time per day, after eating. Tablets should be swallowed entirely, not chewing and drinking sufficient liquid.

The dose of ciprinol CP depends on the severity of the disease, the type of infection, the state of the body, age, body weight and the kidney function.

Side effect

• nausea, vomiting;
• diarrhea;
• pseudomambranous colitis;
• flatulence;
• decline in appetite;
• cholestatic jaundice (especially in patients with pastry-free liver diseases);
• hepatitis;
• increasing the activity of hepatic transaminases, SFF, LDH, bilirubin;
• headache;
• dizziness;
• increased fatigue;
• sense of anxiety;
• an increase in intracranial pressure;
• insomnia;
• nightmare dreams;
• confusion of consciousness;
• depression;
• hallucination;
• fainting;
• migraine;
• cerebral arteries thrombosis;
• disorders of taste and smell;
• violations of vision (diplopia, change in color perception);
• noise in ears;
• reduction of hearing;
• tachycardia;
• heart rate disorders;
• arterial hypotension;
• tides (with in / in administration);
• eosinophilia, leukopenia, thrombocytopenia, neutropenia, anemia, thrombocytosis, hemolytic anemia;
• arthritis;
• tendovaginit;
• rupture tendons;
• arthralgia;
• malgy;
• interstitial nephritis;
• glomerulonephritis;
• hematuria;
• urine delay;
• skin itch;
• hives;
• swelling quinque;
• stevens-Johnson syndrome;
• layella syndrome;
• candidiasis;
• general weakness;
• photosensibilization;
• increased sweating;
• phlebitis.

Contraindications

• pseudomambranous colitis (for in / in administration);
• deficiency of glucose-6-phosphate dehydrogenase (for in / in administration);
• pregnancy;
• lactation period (breastfeeding);
• children's and teenage age up to 18 years;
• increased sensitivity To ciprofloxacin or other drugs from the group of fluoroquinolones.

Application in pregnancy and breastfeeding

Ciprinol is contraindicated to use during pregnancy and during lactation (breastfeeding).

Application in elderly patients

With caution prescribe the drug to elderly patients.

Application in children

Contraindicated to children and adolescents under the age of 18.

special instructions

When developing during or after treatment, ciprofloxacin of severe and long-term diarrhea should eliminate the diagnosis of pseudomembranous colitis, which requires immediate cancellation of the drug and the appointment of appropriate treatment.

In the occurrence of pain in tendons or when the first signs of tendovaginite appears, treatment should be discontinued due to the fact that some cases of inflammation and even breaking tendons during fluoroquinolone treatment are described.

During the period of treatment, an increase in the recommended daily dose is unacceptable in order to avoid the development of crystallurium. Patients should receive a large amount of fluid to maintain a normal diurea and urine acid reaction.

Due to possible photosensibilization during the treatment period, contact with direct sunlight should be avoided.

During treatment, patients should not use alcohol.

Impact on the ability to driving vehicles and management of mechanisms

When applying the drug should be refracted from classes potentially hazardous species Activities requiring increased concentration and speed of psychomotor reactions.

Medicinal interaction

With the simultaneous use of Ciprinol with a didanosin, the absorption of ciprofloxacin decreases due to the formation of ciprofloxacin complexes with salts of magnesium and aluminum contained in the didanosine.

Due to the decline in the activity of microsomal oxidation processes in hepatocytes, ciprofloxacin increases the concentration and increases the half-life of theophylline and other xanthines.

With the simultaneous use of ciprofloxacin and oral hypoglycemic drugs, indirect anticoagulants notes a decrease in the prothrombin index.

With the simultaneous use of ciprofloxacin and non-steroidal anti-inflammatory agents (NSAIDs) (excluding acetylsalicylic acid) increases the risk of convulsion.

The simultaneous reception of antacids, as well as preparations containing aluminum, zinc, iron and magnesium ions, can cause a decrease in the suction of ciprofloxacin, so the interval between the purpose of these drugs should be at least 4 hours.

With the simultaneous use of ciprofloxacin and cyclosporine, the nephrotoxic effect of the latter increases.

Metoklopramide accelerates the absorption of ciprofloxacin, which leads to a decrease in the time to achieve its maximum concentration in the blood plasma.

The joint purpose of uricosuric drugs leads to a slowdown in the removal (up to 50%) and an increase in the plasma concentration of ciprofloxacin.

When combined with other antimicrobial preparations (beta-lactam antibiotics, aminoglycosides, clindamycin, metronidazole), synergism is usually observed. Cyprinol can be used in combination with azlocillin and ceftazidim in infections caused by Pseudomonas SPP.; with meslocillin, azlocillin and other beta-lactam antibiotics - streptococcal infections; with isoxazolpenicillins and vancomycin - with staphylococcal infections; with metronidazole and clindamycin - with anaerobic infections.

Analogs of the drug Tsiprinol

Structural analogues for the acting substance:

• Alzipro;
• Aphenoxin;
• Basiden;
• Betaciprol;
• Zindoline;
• Ichproo;
• Quintor;
• Quipro;
• Liprokhin;
• Microflox;
• Optocipro;
• Procipro;
• Recycling;
• Siflox;
• Chapels;
• Cyloxan;
• Tsipraz;
• Cyprinol CP;
• Cyphrobay;
• Cigrobid;
• Cyprobrin;
• Cymprodox;
• Cyprolacer;
• Cyprolet;
• Ciprolon;
• Cipromed;
• Cipropan;
• Ciprosan;
• Cinsine;
• Ciprosol;
• Ciprofloxabol;
• Ciprofloxacin;
• Cyter;
• Digitalinal;
• Digital;
• Ecocyfol.

In the absence of analogues of drugs on the active substance, you can follow the links below on the disease, which helps the appropriate drug, and see the analogues on therapeutic effects.

Pills Ciprinol have in line Ciprofloxacin hydrochloride monohydrate , Silicon dioxide, sodium crossarmellos, sodium carboxymethyl starch, magnesium stearate, pose, microcrystalline cellulose, propylene glycol, titanium dioxide, talc.

As part of the solution Ciprinol The following substances are contained: Laktat Ciprofloxacin , sodium chloride, hydrochloric acid, water,

Form release

The drug is produced in the form of an infusion solution. This is a transparent liquid having a yellowish green shade.

Also implemented concentrate, which is used to prepare the solution. This is a transparent or yellowish-greenish solution.

Tablets Ciprinol 250 mg Two-screw, have a round shape, white, beveled edges. They are covered with a film shell, on one side of the tablet there is a notch.

Tablets Ciprinol 500 mg double-screwed, have an oval shape, white. The tablet covers the film shell, on the one hand there is a notch.

Tablets Ciprinol 750 mg have an oval shape, have a wrapped shell of white color, a notch is on both sides of the pill.

pharmachologic effect

Ciprinol (Ciprofloxacin) has an antibacterial effect on the body. This is a monofluorine second-generation fluoroquinolone. Under its effect, topoisomerasis II is inhibited, an enzyme that determines the replication and biosynthesis of deoxyribonucleic acid bacteria. It takes an active part in the process of dividing bacteria cells and in the biosynthesis of proteins.

Ciprinol has a bactericidal effect, it is most effective in relation to gram-negative bacteria. Therefore, the drug is used in the treatment of diseases caused by these bacteria.

Also, a certain range of gram-positive bacteria is sensitive to Cyprinol: Staphylococcus SPP., Streptococcus SPP. It affects a number of intracellular microorganisms.

The high efficiency of the drug is noted in the treatment of infectious diseases provoked by a blue rod. Ciprinol is low-effective in relation to chlamydia, anaerobov, mycoplasmas. Mushrooms, viruses, the simplest mainly show resistance to the action of the drug.

Pharmacodynamics and pharmacokinetics

Ciprinol in the form of tablets is quickly absorbed, falling into the gastrointestinal tract. It does not affect its absorption, its bioavailability does not decrease. Bioavailability is 50-85%. Maximum concentration active substance In the blood of the patient, it is noted about 1-1.5 hours after receiving the tablets. After suction, the active ingredient is distributed in the tissues of the urinary and respiratory tract, in the synovial fluid, muscles, skin, fatty tissues, in saliva, sputum, cerebrospinal fluid. It also enters cells (macrophages, neutrophils), which determines its effectiveness in the treatment of infectious diseases in which the pathogens are localized intracellularly.

As a result of biotransformation occurring in the liver, lowactive metabolites appear. The drug is derived from the body through the kidneys, as well as by the action of outreach mechanisms (with feces, with bile). The half-life of the drug from the body ranges from 5 to 9 hours. Consequently, for effective therapy, it is enough to take a drug twice a day.

After the infusion of the intravenous solution of the Ciprinol, the maximum concentration is achieved after 1 hour. When administered intravenously, the active distribution in the tissues of the body, in which a higher concentration is marked active substance Compared to blood plasma. Ciprofloxacin penetrates well through the placenta.

In people with normal kidney functions, the half-life of the preparation ranges from 3 to 5 hours. In patients suffering from renal failure, half-life increases to 12 hours.

After the infusion, the drug is excreted through the kidneys. In constant form, approximately 50-70% of the drug is derived, another 10% is displayed as a metabolite, the rest is through the digestive tract. A small percentage of the active substance is distinguished with breast milk.

Indications for the use of ciprinol

CiPrinol is prescribed if necessary for treating infections that were provoked by microorganisms with high sensitivity to ciprofloxacin, from which a person has a certain disease. Therefore, indications for use drug Next:

• infectious diseases of the respiratory tract: , fibrosis, bronchiectatic disease, etc.;
• infectious ENT diseases :, mastoid ,;
• infectious diseases of urinary tract and kidney : , ;
• infectious diseases of the genital organs, as well as other small pelvis organs :, epididimitis, salpingit, etc.;
• infectious diseases of the abdominal organs : , cholangitis, intraperous abscess, developing due to infection, etc.;
• skin and soft tissue infections : ulcers, burns and wounds of infectious origin, phlegmon ,;
• infectious diseases of the musculoskeletal system : Septic arthritis ,;
• development of sepsis, infections in people with disturbed;
• preventive measures to prevent the development of infections in surgical and orthopedic operations;
• therapy and prevention of the pulmonary form of Siberian ulcers.

Contraindications

Cyprinol cannot be prescribed for the following diseases and states:

• a high level of sensitivity to ciprofloxacin, other drugs belonging to the group of fluoroquinolones or any other components.
• and feeding time;
• age up to 18 years (with the exception of the treatment of complications provoked by Pseudomonas Aeruginosa, in children from 5 to 17 years old, which are sick of lung fibrosis; also used for therapy and prevention of Siberian ulcers in children);
• it is impossible to use the drug at one time with.

Caperinol is prescribed with patients with severe brain vessels, impaired blood flow in the brain, as well as people suffering from mental illnesses, kidney or hepatic insufficiency. It should be clearly controlled by the state of the elderly who pass the course of treatment with the drug, as well as those who have a lack of glucose-6-phosphate dehydrogenase.

Side effects

• Digestive system : Complex of dyspepsic phenomena, hepathonecosis, cholestatic jaundice, pseudomambranous colitis.
• Central nervous system: , high level and, fainting, convulsions, excitement, increase in GFF, disturbances, hallucinations, other psychotic reactions.
• Feeling authorities: disorders, smell, hearing, periodic appearance of noise in the ears.
• The cardiovascular system : Problems with heart rhythm, downgrade arterial pressure, Periodic tides of blood to face.
• Blood-formation system : anemia, leukopenia, thrombocytopenia, granulocytopenia, thrombocytosis, leukocytosis.
• urinary system : Crystaluria, Hematuria, , polyuria, dysuria, albuminuria, bleeding, jade, reducing the nominality of the kidneys.
• Manifestations of allergies :, Itching the skin, the appearance of blisters and bleeding, point hemorrhages, medicinal fever, swelling, vasculitis, examine, etc.
• Bone-muscular system :, Arthralgia, tenders, tendovaginit, Malgy ,.
• Other manifestations :, Sensitivity to the light, state of general weakness.
• By laboratory indicators : Increasing the activity of hepatic transaminases and SCF, Hypoprothrombinemia, hyperuricemia, hypercreaticinemia, hyperbilirubinemia, hyperglycemia.
• With infusual administration, local reactions may appear.

Instructions for the use of ciprinol (method and dosage)

Both intravenous administration of the solution of Ciprinol and CiPrinol 500 mg (in tablets) is assigned twice a day. With light forms of infectious diseases of the urinary or respiratory tract, as well as at a single dose of 250 mg preparation. With severe forms of diseases or with complicated infections, the patient should receive 500 or 750 mg of the drug.

The instruction on Ciprinol 500 mg provides that the drug is taken in this dose once again. If the intravenous administration of the means is practiced, it is necessary to conduct a slow infusion, while the dose of the drug is 200-400 mg. If the patient is diagnosed with acute, it is once intravenously introduced 100 mg of ciprinol. In order to prevent postoperative infectious complications about 1 hour before the surgical intervention, the patient introduces 200-400 mg of Cyprinol.

If the patient has a violation in the work of the kidneys, then the daily dose of LS for oral administration is reduced by two times.

It is necessary to drink tablets before meals, while it is important to put the drug with plenty of water.

Overdose

In case of overdose, a series of symptoms may be marked:, headache, vomiting, nausea, diarrhea. In the case of a strong overdose, disturbances of consciousness, tremor, convulsions, manifestation of hallucinations are possible.

Symptomatic therapy is carried out, it is important to ensure a patient to carry out a sufficient amount of fluid, carrying a stomach. Also prescribed laxatives, activated carbon.

Interaction

If at the same time carry out treatment Tsiprinol and Didanosin, there is a decrease in the suction of ciprofloxacin.

Under the influence of ciprofloxacin, concentration increases and the half-life from the body of theophylline and other xanthines increases.

With parallel treatment with ciprofloxacin and oral hypoglycemic agents, as well as indirect anticoagulants The prothrombin index is reduced.

It is possible to develop seizures while taking Ciprofloxacin and NSAIDs.

Suction of ciprofloxacin may decrease with a parallel antacid treatment, drugs that contain aluminum, iron, zinc, magnesium ions. It is important to ensure the interval between the reception of these drugs, which is at least 4 hours.

If ciprofloxacin is used at the same time and, then the nephrotoxic effect of the latter is enhanced.

With alcohol

Forbidden to accept alcoholic beverages In the process of treatment with ciprinol.

Children

The drug can be appointed for the treatment of children and adolescents up to 18 years only if necessary therapy and prevention of Siberian ulcers, as well as in the treatment of complications provoked by Pseudomonas Aeruginosa, in children who are of lung fibrosis.

During pregnancy and lactation

Cyprinol cannot be prescribed for the treatment of pregnant women, as well as nursing mothers. Breastfeeding must be immediately stopped.

Composition and form of release of the drug

Tablets covered with film shell White or almost white, oval, with notch on both sides.

Auxiliary substances: Cellulose Microcrystalline, sodium starch glycolat, sodium carboxymethylcellulose, silicon colloidal dioxide, magnesium stearate, hydroxypropylmethylcellulose (hypimodelloosis), propylene glycol, talc, titanium dioxide (E171).

10 pieces. - Blister (1) - packs cardboard.
10 pieces. - Blisters (2) - packs cardboard.

pharmachologic effect

A wide range of a group of fluoroquinolones. It has a bactericidal action. Suppresses the DNA gyrase and inhibits the synthesis of bacterial DNA.

Highly active with respect to most gram-negative bacteria: Pseudomonas Aeruginosa, Haemophilus Influenzae, Escherichia Coli, Shigella SPP., Salmonella SPP., NEISSERIA MENINGITIDIS, NEISSERIA GONORRHOEAE.

Active in terms of Staphylococcus SPP. (including strains producing and non-producing penicillinase, metaticillin resistant strains), some ENTEROCOCCUS SPP strains., Campylobacter SPP., Legionella SPP., Mycoplasma SPP., Chlamydia SPP., Mycobacterium SPP.

Ciprofloxacin is active with respect to bacteria producing β-lactamases.

Ciprofloxacin resistant Ureaplasma Urealyticum, Clostridium Difficile, Nocardia Asteroides. The action against Treponema Pallidum is not studied enough.

Pharmacokinetics

Quickly absorbed from the gastrointestinal tract. Bioavailability after receiving inside is 70%. Eating is slightly affecting the suction of ciprofloxacin. Protein binding is 20-40%. It is distributed in the tissues and body fluids. Penetrates the spinal fluid: the concentration of ciprofloxacin with non-concentrated brain shells reach 10%, with inflamed - up to 37%. High concentrations are achieved in bile. Stands out with urine and bile.

Indications

Infectious inflammatory diseases caused by microorganisms sensitive to ciprofloxacin, incl. diseases of the respiratory tract, abdominal cavity and organs of small pelvis, bones, joints, leather; septicemia; Heavy infections of ENT organs. Treatment of postoperative infections. Prevention and treatment of infections in patients with reduced immunity.

For local applications: sharp and subacute conjunctivitis, blufurokonjunctivitis, blufare, bacterial corneal ulcers, keratitis, keratoconjunctivitis, chronic dacryocystitis, meibomites. Infectious eye lesions after injury or hitting foreign languages. Preoperative prophylaxis in ophthalmic surgery.

Contraindications

Pregnancy, lactation ( breast-feeding), Children's and adolescent age up to 18 years, increased sensitivity to ciprofloxacin and other drugs of quinolone row.

Dosage

Individual. Inside - 250-750 mg 2 times / day. The duration of treatment is from 7-10 days to 4 weeks.

For in / in administration, one-time dose - 200-400 mg, the multiplicity of administration - 2 times / day; The duration of treatment is 1-2 weeks, if necessary and more. Can be introduced in / in the jet, but more preferably drip administration For 30 minutes.

Under the local application, they bury 1-2 drops into the lower conjunctival bag of the affected eye every 1-4 hours. After improving the status, the intervals between the instillations can be increased.

Maximum daily dosefor adults when taking inside is 1.5 g.

Side effects

From side digestive system: Nausea, vomiting, diarrhea, abdominal pain, increase in activity of hepatic transaminases, SHF, LDH, bilirubin, pseudomambranous colitis.

From the CNS: Headache, dizziness, feeling of fatigue, sleep disorders, nightmare dreams, hallucinations, fainting, vision disorders.

From the urinary system: Crystalluria, glomerulonephritis, dizuriuria, polyuria, albuminuria, hematuria, transient increase in creatinine blood serum.

From the hematopopitation system: Eosinophilia, leukopenia, neutropenia, changing the number of platelets.

Sides of cardio-vascular system: Tachycardia, rhythm disorders, arterial hypotension.

Allergic reactions: Skin itching, urticaria, swelling of quinque, Stevens-Johnson syndrome, arthralgia.

Side reactions associated with chemotherapeutic effects: candidiasis.

Local reactions: soreness, phlebitis (when in / in administration). When using eye drops, in some cases, light pain and hyperemia of conjunctiva are possible.

Others: Vasculitis.

Medicinal interaction

With the simultaneous use of ciprofloxacin with a didanosin, the absorption of ciprofloxacin is reduced due to the formation of Ciprofloxacin complexions with aluminum and magnesium buffers contained in the didanosine.

With simultaneous use with increasing the risk of bleeding.

With the simultaneous use of ciprofloxacin and theophylline, it is possible to increase the concentration of theophylline in the blood plasma, an increase in T 1/2, which leads to an increase in the risk of developing toxic effects associated with theophylline.

The simultaneous reception of antacids, as well as preparations containing aluminum, zinc, iron or magnesium ions, can cause a decrease in the suction of ciprofloxacin, so the interval between the purpose of these drugs should be at least 4 hours.

special instructions

In patients with impaired kidney function, the dosing mode correction is required. Caution is used in elderly patients, in atherosclerosis of brain vessels, brain circulation disorders, epilepsy, convulsive syndrome Unclear etiology.

During treatment, patients should receive a sufficient amount of fluid.

In the case of a stubborn diarrhea, ciprofloxacin should be canceled.

With simultaneous in / in the introduction of ciprofloxacin and barbiturates, control of heart rate, blood pressure, ECG is required. In the process of treatment, control of urea, creatinine blood concentrations, and hepatic transaminases are needed.

During the treatment period, a decrease in reactivity is possible (especially with simultaneous use with alcohol).

It is not allowed to introduce a ciprofloxacin subconjunctive or directly into the front chamber of the eye.

The drug antimicrobial drug Ciprinol 500 is used to counteract the infectious damage to the body causing inflammatory processes. The poisoning effect on pathogens leads to the destruction of topoisomerase - the main enzyme of the life of microorganisms. The shell of bacteria is broken and the general reproduction is suspended.

Other names and classification

International non-proprietary title

Ciprofloxacin

Trade names

The names of the CIPRINOL CP, Ciprolon, Ciprex, Ciprofloxacin are used.

Registration number

LSR-007078/08 dated December 14, 2015

Composition and dosage forms

A ciprofloxacin in the form of hydrochloride monohydrate is used as an active substance in the manufacture of hydrochloride monohydrate. Its concentration is 500 mg. Additional components are present in the tablet:

• microcrystalline cellulose;
• sodium powder Croskarmellose;
• sodium starch in type A;
• talc;
• titanium dioxide;
• silica;
• propylene glycol;
• hydromellos.

Available in the tablets of oval shape with a white-colored shell, a notch is made on one side. The plate is 5 or 7 pcs., 1 (7 pcs.) Or 2 (5 pcs.) Blisters are packed in a cardboard box.

Pharmacological group

Antibacterial action tools intended for system use. According to an anatomy-therapeutic-chemical classifier (ATX), the code J01ma02 is assigned.

pharmachologic effect

The action is manifested in respect of an extensive spectrum of pathogens. The antibiotic suppresses complex complexes of molecules necessary for the development and life of microorganisms. Efficiency is determined by the relationship between the required amount to inhibit the pathogen and the volume contained in the blood serum.

The substance is absorbed for a short time, getting into the upper part thin gut. The maximum content is detected in serum after 1-2 hours. The amount of substance increases with increasing the rate of reception. Biological accessibility is at 75-80%.

Ciprofloxacin slightly binds to blood proteins - 25-30%. The substance penetrates into the space between the vessels and is formed in the concentration tissues exceeding the volume in the blood. Ciprofloxacin is found in tissues:

• epithelial layer of lungs;
• alveolar protective cells;
• damaged cells;
• urinary tract;
• endometrial of genital organs;
• samples when fence on analysis.

The half-life is 5-7 hours at good kidney work. The substance leaves the body by 80% unchanged through the intestine and the urinary system.

What helps Cyprinol 500?

Medicine is assigned after receiving data on the resistance of the detected pathogen to ciprofloxacin. Tsiprinol treats diseases caused by pathogenic microorganisms:

Cyprinol application and dosage method 500

The dosage is selected taking into account the place of infection in the body, the sensitivity of infectious agents and the severity of the disease, prescribes the doctor's tablets. The work of the kidneys is taken into account, and in children - and body weight. The duration of therapy depends on the reaction of the organism, the features of the course of the disease and the type of pathogen.

Getting rid of some types of pathogens, such as staphylococcal infection, requires the use of high doses of ciprofloxacin with joint assignment of other antibiotics, use of injections. Combined therapy is required in the treatment of inflammations of sexual, urinary organs, stomach and intestines, as well as with a state of considerable diseases.

The drug is applied 2 times a day, the dose of the reception is 500 mg. The dosage varies in the direction of increasing or decreasing depending on the severity. On average, the course lasts 5-10 days.

The tablet cannot be chewed, it is swallowed entirely, an empty stomach substance is absorbed faster. It is not recommended to simultaneously use dairy products or juices from fruits with mineral additives.

special instructions

Cyprinol is not prescribed in the form of monotherapy to get rid of severe infectious damage caused by representatives of anaerobic or gram-positive groups of bacteria. Treatment of streptococcus Ciprofloxacin is inefficient. Therapy of inflammation of the urinary tract is carried out taking into account resistance and local microorganisms.

With uncomplicated forms of cystitis in the period before the climax, women are effective for a long period of treatment compared to single receptions. This is taken into account with an increase in resistance. The medication is appointed if other drugs are excluded, the choice is based on the results of the study in the laboratory.

Infectilation of joints and bone tissue is treated after the exclusion of tendons breaks through the study, Ciprinol is applied in combination with other antibiotics. The use of the drug is justified in the case of severe specific infectious lesions according to the results of the tests after assessing the risk and benefit ratio.

The use of ciprofloxacin in patients with diseases of tendons or, if in past periods, disorders caused by quinolona occurred. Medicine is assigned in exceptional cases, if there is no possibility to apply other medicines. Therapy threatens the development of tendinite, inflammation of the tendon and its gap sometimes from 2 sides. Complications arise within 2 days after the reception.

A few cases of photosensitization are registered, so in the treatment of antibiotic, patients avoid sunlight or ultraviolet radiation in cosmetic clinics. The use of the drug affects the threshold of seizures, so there are often unpleasant sensations. In order to avoid further disorder, the CNS ceases to use the medical process. Changes in the work of the nervous system are observed even after the first adopted doses. Rarely psychosis or depressive state may cause suicide attempt. The drug is immediately canceled.

For patients with heart disorders, the use of fluoroquinolones requires caution and regular monitoring of the system. There is the possibility of elongation of the Qt interval in patients:

• with the hereditary predisposition to pathology;
• in the case of the simultaneous use of antiarrhythmic agents of the category AI and AIII, macrolides, antidepressants, neuroleptics;
• in case of violation of the balance of electrolytes in the body (lack of potassium and magnesium);
• with diagnosed insufficiency of the heart, after a heart attack, in bradycardia, the development of arrhythmia;
• in older patients.

Patients S. diabetes The risk of hypoglycemia appears, more often in the elderly, therefore the control of sugar is required. Reception of the drug is not recommended after the treatment of diarrhea in severe form or in case of diarrhea during therapy. Cyprofloxacin is canceled and appropriate medicines are prescribed, which do not reduce intestinal peristalsis.

Drink a lot of water to reduce the risk of crystalluria, reduce the use of alkali-row products. Rarely arise anaphylactic reactions that develop to a shock state. As a result of the use of Ciprinol, hepatic necrosis and failure of the body can develop. In the case of vomiting, cholestatic jaundice, increasing the number of transferases, the level of alkaline phosphatase medication is immediately canceled.

During pregnancy and breastfeeding

As a result of examinations of pregnant women using Cyprinol, deviations were detected when entering the child, disruption of the development of the fetus and placenta. Theoretically, the embryo is dangerous risk of incorrect development of cartilage in newborns. The use of the drug during pregnancy is excluded.

Because of the penetration of Ciprofloxacin, the risk of negative action arises into women's milk children's organism, in particular, damage to the joints and cartilage. Treatment with ciprinol is not recommended when feeding the child with maternal milk.

In childhood

Treatment is carried out only according to the official current recommendations. Preparation B. childhood Appoints the doctor, self-medication is unacceptable. Recommendations for therapy:

• cystic fibrosis is treated at the rate of 20 mg per kilogram of the weight of the child, the duration of the course - from 10 to 14 days;
• pyelonephritis, complex infections of the urinary system and pathological examinations internal organs Treating in an amount of from 10 to 20 mg / kg 2 times a day at a maximum rate of 750 mg, the duration of the course is from 10 to 21 days.

Heavy infections therapy begins after an objective assessment of the situation.

In old age

For the elderly, the choice of dosage and the duration of the course is determined in accordance with the severity of infection. If a person has no deviations of creatinine clearance, severe diseases of internal organs and other contraindications, the therapy is assigned standard.

With violations of the kidney function

Due to the fact that ciprofloxacin is derived from the body for the most part Through the kidneys and ureters, then when choosing treatment, pay attention to the condition of the urinary system. To avoid the accumulation of substance in the body, adjust the dose of the drug.

Cyprinol side effects 500

Most often comes complaints about the development of diarrhea, the appearance of nausea, turning into vomiting. Side manifestations Look as follows:

• invasions, damage to fungi, antibiotic colitis are developing;
• blood and lymph system react with thrombocytopenia, eosinophilia, leukopenia, agranulocytosis, inhibition of bone marrow operation;
• the immune system issues allergic or anaphylactic reactions, angioedema edema, serum symptoms;
• disorders of nerves in the form of excitation, confusion of consciousness, anxiety, bad dreams, hallucinations;
• the appetite is reduced, hurts in the intestinal area and stomach;
• the perception of color is disturbed, vision is worse;
• the level of transaminase, bilirubin increases.

Contraindications