Tsetrin: indications for use, analogues. From what tablets Cetrin: purpose, application features and possible side effects Is it possible for pregnant women to take cetrin

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The site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. A specialist consultation is required!

Medicinal product Cetrin represents antihistamine, which is intended to eliminate the symptoms of an allergic reaction in children and adults. Cetrin belongs to the group of selective (selective) antihistamines, also called histamine blockers ... The drug does not have a strong sedative effect and depression of the central nervous system, therefore it is used mainly as an antiallergic agent, starting from 2 years.

Release forms

Cetrin is manufactured by the Indian pharmaceutical corporation DR. REDDY`S LABORATORIES, LTD in the form of tablets and syrup. The syrup is often referred to as "baby Cetrin" because it is this form that is used to treat allergy symptoms in a child. You can also find the common name "Cetrin drops" instead of the correct "syrup", which is used to refer to the liquid dosage form of the drug. In this case, "Cetrin drops" \u003d "Cetrin syrup", that is, we are talking about the same dosage form, simply named differently.

Cetrin syrup is available in dark glass bottles with a volume of 30 and 60 ml. A measuring spoon is included with each bottle. The syrup is transparent, uncolored (a slight yellowish tint is allowed), homogeneous, does not contain suspended particles. Slight opalescence is possible. It has a pleasant fruity scent.

The tablets are sold in packs of 10, 20 and 30. The tablet itself has a round, biconvex shape and a risk on one side. Covered on top with a white film.

Composition and dosage

Tablets and syrup contain as an active ingredient chemical substance cetirizine. The dosage of cetirizine in one tablet is 10 mg, and in syrup - 1 mg in 1 ml. Therefore, if it is necessary to take Cetrin in small doses (less than 10 mg), it is better to use syrup rather than tablets. In this case, you can always measure the exact amount of syrup in ml, which will contain the required dose. active substance... And the pill can only be broken in half.
The syrup contains the following substances as auxiliary components:

• glycerol;
• sucrose;
• benzoic acid;
• sodium edetate;
• sorbitol;
• sodium citrate;
• fruit flavoring.

Tablets contain the following substances as auxiliary components:

• lactose;
• corn starch;
• povidone;
• magnesium stearate.

Cetrin - the generation of antihistamines

Today there are only three generations of antihistamines. Cetrin belongs to the second. Consider general characteristics and the main differences between the three generations of histamine blockers from each other.

The first generation of antihistamines (Suprastin, Tavegil, Diazolin, Fenistil, etc.) has an indiscriminate effect on receptors. That is why drugs block histamine receptors located in the central nervous system and organs of the digestive tract. The consequence of this indiscriminateness is the powerful inhibitory effect of drugs, which is the most significant side effect (drowsiness). In short, first-generation antihistamines are characterized by potent anti-allergic effects and severe side effects such as drowsiness.

Second generation antihistamines (Zirtek, Zodak, Tsetrin, Cetirizin, Parlazin, etc.) is characterized by a significantly lower influence on the central nervous system due to selective action on receptors. This means that the side effect in the form of CNS depression and drowsiness in the second generation drugs is much less pronounced than in the first. Unfortunately, the antiallergic effect of the second generation drugs is also less pronounced than that of the first. Thus, the short characteristic looks like this: less pronounced drowsiness and less efficacy against allergy symptoms, compared to the first generation drugs.

Third generation antihistamines (Claritin, Erius, Telfast, etc.) has a high selectivity of action on histamine receptors. Therefore, these drugs have practically no effect on the central nervous system, that is, they do not cause drowsiness. However, the severity of antiallergic action in the third generation drugs is not lower than in the first. Thus, a brief description of these antihistamines is as follows: a powerful antiallergic effect and almost complete absence of side effects on the central nervous system in the form of drowsiness.

Cetrin tablets for allergies (therapeutic effects)

The therapeutic effects of Cetrin are due to the active substance - cetirizine, which is a blocker histamine receptors... This means that cetirizine binds to receptors and blocks them. As a result, the released histamine cannot bind to its receptors and has no effect. Namely, histamine is responsible for the development of manifestations of an allergic reaction (itching, redness, swelling, rash, etc.). Thus, Cetrin blocks the development of an allergic reaction at the cellular level and, thereby, prevents the formation of its external manifestations (pain, itching, edema, etc.).

In addition, Cetrin reduces the amount of histamine released and reduces the migration of eosinophils to the site of an allergic reaction. A decrease in the number of eosinophils in the focus of allergic inflammation leads to a significant decrease in the severity of the late stages of the hypersensitivity reaction. Also, Cetrin has a general anti-inflammatory effect, inhibiting the production of cytokines that support the inflammatory response.

When used in courses as a prophylactic agent, the drug has the ability to reduce the readiness for the development of an allergic reaction in the cells of the bronchi, which leads to a decrease in the frequency of attacks in patients with asthma. In the same way, Cetrin suppresses the development of an allergic skin reaction in people suffering from urticaria and dermographism.

The therapeutic effect of Tsetrin begins 20 minutes after taking the drug, and lasts up to 24 hours. Therefore, it is sufficient to take it only once a day. After stopping the use of the drug, the readiness for the development of allergic reactions is restored after three days.

Thus, the main therapeutic effects of Cetrin are as follows:
1. Eliminates itching.
2. Relieves and prevents swelling.
3. Relieves smooth muscle spasm.
4. Reduces capillary permeability and fluid release into tissues.

Indications

Syrup and tablets are used to eliminate allergy symptoms in the following conditions:

• seasonal or year-round runny nose;
• allergic conjunctivitis;
• hay fever;
• hives of any type;
• dermatoses with severe itching (for example, neurodermatitis, atopic dermatitis, etc.);
• itching of any origin other than that caused by cholestasis;
• bronchial asthma;

Tsetrin - instructions for use (how to take)

Both tablets and Cetrin syrup are taken orally, regardless of food, with a small amount of plain water. Syrup can be given to children from 2 years of age, and tablets - only from 6 years. Since the drug is long lasting, it can only be taken once a day. And it is better to do this in the evening, before going to bed, so as not to experience any discomfort associated with possible drowsiness during the day.

How to take Cetrin syrup

The dosage is determined by the person's age:
1. Children from 2 to 6 years old take 5 ml of syrup (5 mg) once a day, in the evening. If the child does not tolerate such a dose, it can be divided into two doses - 2.5 ml of syrup 2 times a day, morning and evening.
2. Children over 6 years old and adults take 10 ml of syrup (10 mg) once a day, in the evening, before bedtime. If necessary, you can distribute the dose of 10 mg in two doses - 5 ml of syrup in the morning and evening.

Seniors without kidney disease can take Cetrin at the usual adult dosage.

Patients suffering from renal insufficiency should use Cetrin in doses that depend on the value of the glomerular filtration coefficient, determined using the Reberg test. The dosage of Cetrin for people with renal failure is shown in the table:

If, in response to taking Cetrin syrup, a hypersensitivity reaction develops, you must immediately stop using the drug.

Before carrying out an allergy test (Prike test), it is necessary to stop taking Cetrin for 3 to 4 days in order not to get false negative results.

Adults should refrain from drinking alcohol while using Cetrin. Also, against the background of using the drug, it is necessary, if possible, to abandon any activity that requires an increased concentration of attention and a high speed of reactions.

Interaction with other medicines. Concomitant use with theophylline leads to an extension of the action time of Cetrin for more than 24 hours.

Overdose Tsetrina is possible with a single dose of more than 50 ml of syrup. Overdose symptoms are:

• drowsiness;
• cessation of urine flow;
• anxiety and increased irritability.

When treating an overdose, first of all, gastric lavage is performed to remove the remnants of the drug from the body. In this case, hemodialysis is ineffective. If necessary, symptomatic drugs are used to maintain normal pressure, urination, breathing, etc.

How to take Cetrin tablets

Children can only take the drug in pill form from the age of 6. The tablets are taken orally, not chewed, but simply swallowed and washed down with a small amount of plain water. Since the drug has a long-term effect, the tablet must be taken only once a day. It is best to take Cetrin in the evening so as not to experience discomfort from possible sleepiness during the day.

The dosage of the tablets is the same for adults and children over 6 years of age. Usually adults take 1 tablet (10 mg) once a day (preferably in the evening). And for children, a daily dose of 10 mg is divided into two doses - half a tablet (5 mg) twice a day, morning and evening.

Patients with impaired renal function should take Cetrin tablets in half the dosage, that is, half a tablet (5 mg) once a day. In the presence of renal failure there may be an accumulation of the drug in the blood, which increases the risk of side effects.

If a hypersensitivity reaction develops while taking pills, you should immediately stop using them and consult a doctor. Before carrying out an allergy test (Prike test), you must stop using Cetrin tablets at least 3 days in advance.

During treatment should be avoided alcoholic beverages... Since the drug can lead to the development of drowsiness, you should also avoid any activity that requires a high concentration of attention and speed of reactions.

Overdose Cetrin is possible when taking more than 3 to 4 tablets at a time. Symptoms of this condition are drowsiness, anxiety, itching, rash, urinary retention, fatigue, tremors (shaking limbs), tachycardia (palpitations). To treat an overdose, first of all, you should remove the remains of the drug from the body by washing the stomach. Hemodialysis should not be performed as this procedure is ineffective in removing Cetrin from the blood. If necessary, symptomatic medications are used to support basic vital functions.

Interaction with other medicinal products has not been identified. However, it is recommended to carefully combine the simultaneous use of Cetrin tablets and drugs that have a sedative effect.

Cetrin for children

Tsetrin is allowed for use in children from 2 years of age. From 2 to 6 years old, it is allowed to use Cetrin exclusively in the form of a syrup, and after 6 years, children can take pills.

Using drug allows you to quickly eliminate the excruciating itching in a child, to whom he delivers especially severe discomfort... After all, a child is often simply not able to restrain his desire to "scratch", he literally scrapes the skin with his nails. As a result, numerous wounds and scratches form on the skin, into which infection easily penetrates. As a result, an allergic reaction is complicated by an infectious process. Relieving excruciating itching, Cetrin normalizes the child's sleep and indirectly prevents the development of skin infections.

In addition, the drug has the ability to reduce the allergic activity of the skin and bronchi. With regular use, this reduces the risk of adhesion respiratory symptoms (spasm of the bronchi, larynx, difficulty breathing, shortness of breath, swelling of mucous membranes, etc.) an allergic reaction to existing skin (itching, redness, swelling, rash). That is, Cetrin prevents dermatitis from becoming a serious disease - bronchial asthma or allergic rhinitis. This spread of symptoms of an allergic reaction from the skin to the respiratory system is called atopic march... This is why doctors talk about Cetrin's ability to prevent atopic march in young children.

The dosage of the drug is determined by the age of the child. Possible options for the use of tablets and Cetrin syrup in children are shown in the table:

Tsetrin tablets must be taken twice a day, since the child cannot be given the entire daily dose at one time.

If the child has impaired renal function, then the daily dosage of Cetrin should be reduced by half. This means that children 2 - 6 years old can take maximum 2.5 ml of syrup per day. Children over 6 years old can take a maximum of 5 ml of syrup per day, or one tablet once every two days.

Doctors recommend using Cetrin syrup for children, since it is more convenient to dose it, and it is better perceived by the child. The kid is more likely to drink a pleasant-smelling syrup than a pill, which is associated with a bitter medicine. Therefore, in order not to inflict unnecessary psychological trauma on the child, it is recommended to give him the drug in the form of a syrup.

If one dose of the drug was missed, nothing needs to be done. Just the next day, continue giving your child Cetrin at the usual dosage without increasing it.

Application during pregnancy

Both syrup and Cetrin tablets are contraindicated for use during pregnancy and during lactation. This is due to the fact that the drug crosses the placenta and can have a negative effect on the formation of the child's brain. When breastfeeding, the drug passes into the mother's milk in large doses. That is why Cetrin is prohibited from use by pregnant women and nursing mothers.

How many days to take Cetrin?

The duration of the use of Tsetrin depends on a number of factors, the determining of which is the severity and nature of the course of the allergic disease.

So, Tsetrin is used to relieve an acute allergic reaction for a maximum of 10 to 14 days. If the symptoms of an allergic reaction disappear faster than after 10 days, then the drug should be stopped earlier. Thus, in the treatment of an acute allergic reaction, the duration of administration is determined by the rate at which the symptoms disappear. As soon as the allergy symptoms disappear, you can immediately stop taking the drug. However, in this case, continuous use of Tsetrin for more than 14 days is not allowed.

When taking Cetrin as a prophylactic agent to prevent exacerbations of allergic diseases (for example, runny nose, hay fever, dermatitis, etc.), a longer course of treatment is required. Usually, the prophylactic course of drug use is 1 - 1.5 months. Doctors recommend taking Cetrin for prophylaxis throughout the entire period of the presence of a potential allergen in the surrounding space. For example, if you are allergic to flowering plants, you need to take Cetrin in May-June, until all the trees have faded.

Also Cetrin can be used for the treatment of bronchial asthma as a basic antihistamine in combination with other drugs. In this case, the drug is taken in a course of 15-20 days, then take a break for 1 week. After the break, the reception is resumed again. This method of taking Cetrin during treatment bronchial asthma have been practicing for years.

Young children (up to 7 years old) prone to allergic reactions according to the type of dermatitis, they can take Cetrin prophylactically 3 - 4 times a year, in short courses of 10 - 14 days. Such prevention is necessary to prevent the atopic march in children prone to true allergic reactions.

Side effects

Cetrin tablets and syrup have exactly the same side effects, which are manifested mainly from the central nervous system. Side effects of both dosage forms of Cetrin from various organs and systems are presented in the table:

Contraindications

Contraindications to the use of syrup and Cetrin tablets are also the same. The drug must not be used in the presence of the following conditions:

• hypersensitivity or allergy to the components of the drug;
• period of pregnancy;
• children under 2 years of age (for syrup);
• children under 6 years of age (for tablets).

Relative contraindications to the use of Tsetrin are renal failure and elderly age human. In these cases, the drug can be used by reducing the usual adult dose and organizing medical supervision of the patient's condition.

Analogs

In the domestic pharmaceutical market, Tsetrin has both analogous and synonymous drugs. Analogues include all drugs from the pharmaceutical group of antihistamines (histamine blockers). The synonyms of Tsetrin include antihistamines, which also contain cetirizine as an active ingredient.

So, the following drugs are synonyms for Tsetrin:

• Alers tablets;
• Allertek tablets;
• Levocetirizine-Teva tablets;
• Cetirizine DS tablets;
• Cetirinax tablets;
• Cetirizine-OBL tablets;
• Cetirizin-Teva tablets;
• Zyrtec tablets and drops;
• Zodak drops, syrup and tablets;
• Letizen solution and tablets;
• Drops and tablets Parlazin;
• Cetirizine tablets;
• Drops, syrup and tablets Cetirizine Hexal;
• Cetrin syrup and tablets;
• Zetrinal syrup and tablets;
• Syrup and tablets Zinzet.

Tsetrin analogs include the following drugs:

• Allerpriv tablets;
• Allerfex tablets;
• Beksist-sanovel tablets;
• Glenzet tablets;
• Gistaphen tablets;
• Gifast tablets;
• Diacin tablets;
• Dimebon tablets;
• Dimedrokhin tablets;
• Dinox tablets;
• Dramin tablets;
• Desloratadine-Teva tablets;
• Klallergin tablets;
• Clarifer tablets;
• Ketotifen-Ros tablets;
• LoraHexal tablets;
• Loratadin Stada tablets;
• Loratadin-Werte tablets;
• Loratadin-Teva tablets;
• Loratadin-OBL tablets;
• Lordestine tablets;
• Rupafin tablets;
• Ciel tablets;
• Telfast tablets;
• Ceser pills;
• Feksadin tablets;
• Fexo tablets;
• Fexofast tablets;
• Fexofenadine tablets;
• Ksizal drops and tablets;
• Claritin drops and tablets;
• Clargotil syrup and tablets;
• Claridol syrup and tablets;
• Clarisens syrup and tablets;
• Clarotadine syrup and tablets;
• Kestin syrup and tablets;
• Ketotifen syrup and tablets;
• Ketotifen Sopharma syrup and tablets;
• Loratadine syrup and tablets;
• Loratadin-Hemofarm syrup and tablets;
• Peritol syrup and tablets;
• Suprastinex drops and tablets;
• Erius syrup and tablets;
• Erolin syrup and tablets;
• Lomilan tablets, lozenges and suspension;
• Dragee and Diazolin tablets;
• Rapido capsules;
• Semprex capsules.

Among the many antihistamines drugs Cetrin is the most popular. The drug is intended to eliminate year-round or seasonal allergies. Cetrin is a second generation antiallergic agent.

The active ingredient of the drug is cetirizine, which blocks H1 - histamine receptors. Cetirizine is unable to block cholinergic and serotonin receptors.

The active substance prevents the appearance of edema, helps relieve smooth muscle spasm. The drug reduces the content in the blood of substances such as neutrophils, basophils, eosinophils, etc. In moderate asthma, the drug reduces bronchoconstriction.

The drug has an antiexudative and antipruritic effect.

Cetrin helps to eliminate the appearance of skin reactions that have arisen due to various factors: cooling, allergens or the introduction of histamine.Cetrin is distinguished by its high absorption capacity and good absorption from the gastrointestinal tract. After taking the drug, the plasma concentration is reached after an hour.

In addition to cetirizine, the drug contains the following substances:

• Sorbic acid
• Talc
• Lactose
• Corn starch
• Magnesium stearate
• Hypromelase
• Povidone

The drug takes effect after being taken as a tablet or syrup after 30 minutes. Cetrin is metabolized in small amounts in the liver, and excreted along with feces. The half-life in adults is about 7-10 hours, and in children it is 6 hours. With proper use and observing the indicated dose, the drug does not cause sedation.

When using the drug during the period breastfeeding there is a possibility of penetration of the active substance into breast milk. After the end of the drug intake, its effect persists for another 3 days.

Prescribing the drug

The drug Tsetrin is prescribed in the following cases:

• Allergic conjunctivitis and
• Allergic form of dermatosis
• Atopic dermatitis
• Chronic urticaria
• Hay fever

The active ingredient of the drug eliminates all signs of allergies: itching, redness, swelling, rashes. The drug can be used at various stages of the manifestation of allergic reactions.

Dosage

The drug can be used not only for medicinal purposes to eliminate symptoms, but also prophylactically to avoid allergic reactions.

The drug can be used for children over 6 years old. The dose of an antihistamine for children from the age of 6 and adults per day is 10 mg. This is one drug. Adults should take the drug in one dose, while children can be divided into two doses: 1/2 tablet in the morning and in the evening.

In renal failure, the dosage is halved. Drink the pill with clean drinking water.

Cetrin in the form of a syrup is taken with or without food. It is better to give medicine to children in the evening before bedtime. for adults and children over 6 years old is 10 ml. It is possible to use the syrup for children under 6 years of age. The dosage of the drug is prescribed by the doctor: 5 ml or 2.5 ml each, depending on the degree of manifestation of allergy symptoms.

More information about allergies can be found in the video.

The course of taking the drug is prescribed for each individual and is generally 1 month. If the allergic condition is very severe, then the period of taking Cetrin is extended to 3-6 months.

Stop taking the drug a few days before the allergy test.During treatment, you should stop drinking alcohol. Alcohol and antihistamines do not work together. If, while taking an antihistamine, alcohol is consumed even in small quantities, then this combination has a depressing effect on the nervous system. As a result, hallucinations and delusional states may appear.

Side effects

When using the drug, they rarely occur. While taking Cetrin, the following side reactions may occur:

• Headache
• Dizziness
• Migraine
• Drowsiness
• Weakness
• Abdominal pain
• Flatulence

If you follow all the doctor's instructions for using the drug, then an overdose is not observed. Disregard for the recommendations of a specialist and use therapeutic doses higher than prescribed can lead to skin rash, itching, urinary retention, tachycardia, constipation, tremor, etc.

If these signs are observed against the background of the use of Cetrin, you should stop taking the antihistamine and rinse the stomach.

If necessary, symptomatic therapy is prescribed using drugs such as Enterosorb, Polysorb, Lactofiltrum, etc. After that, the patient's condition is normalized.The use of the drug is contraindicated in case of intolerance to the components that make up the drug.

The effect of the active substance is reduced with the simultaneous use of Cetrin and Theophylline. When using Cetrin with sedatives, you should be careful.

Application during pregnancy and lactation

Cetrin during pregnancy and lactation

During and during breastfeeding, the use of the drug is prohibited. Almost all antihistamines are not used during pregnancy. This is due to the penetration of the active substance through the placenta, which can affect the development and formation of the fetus. This will mainly affect the formation of the brain and spinal cord.

Histamine is essential during pregnancy. With his participation, the egg after fertilization is attached to the wall of the uterus. Also, this component is involved in the development of the embryo. Histamine is able to regulate the metabolism of the fetus.

You should know that taking medications that suppress the production of histamine is strictly prohibited, since this may not affect the fetus in the best way.

The use of Cetrin by a pregnant woman will negatively affect the functioning of the kidneys and liver. Compared to other antihistamines, Cetrin has a clear advantage. Doctors prescribe medication in rare cases, so a pregnant woman should take it with great care and under medical supervision. In the first trimester of pregnancy, the drug is not used.

During lactation, the active substance in large quantities penetrates into breast milk. Therefore, the child will receive the drug with milk, which should not be allowed.If during the period a woman has an allergic reaction, then you should consult a doctor for a medication that is not contraindicated in pregnancy.

The antihistamine Cetrin is available in a biconvex form and covered with a white shell. One tablet contains 10 mg of the active substance cetirizine.

For children with allergic reactions, Cetrin is used in the form. In this form, the drug is convenient to give to children. The syrup is transparent, sometimes yellowish in color, with a fruity aroma. The package contains a measuring spoon.

When ingested, the drug immediately acts and prevents further development allergies. You can use the drug for no more than 6 months.

The shelf life of the antihistamine is 2 years.

You can not use the drug after the specified period. When storing the drug, be sure to leave the package insert. It is recommended to store the drug in a dark place and avoid direct sunlight. The optimum temperature for storing the drug is 15-25 degrees.

Drug analogues

Types of Tsetrin analogs - antiallergic drugs

Tsetrin has many analogs that differ in therapeutic activity.

Similar antihistamines, where the active ingredient is cetirizine, include Zodak, Zyrtec, Cetirinax, Allertek, Rolinoz, etc. This is the latest generation of antiallergic drugs. Antihistamines do not affect the nervous system and are characterized by powerful therapeutic effects. These drugs are closer to Cetrin not only in composition, but also in the concentration of substances and the form of release.

The price of such drugs is higher, in contrast to other drugs that have the same effect:

• Loratadin
• Ketotifen
• Suprastin
• Claridol
• Diazolin

These are inexpensive analogs of Cetrin, which belong to the first generation. Basically, these drugs cause various side effects and have low therapeutic effects.

Replacement of the drug can only be made by the attending physician, given the sensitivity to the components of the drug and the patient's condition.

Antihistamines last generation much more efficient. Before taking any antihistamine, you should read the instructions.

During pregnancy in women, chronic diseases become aggravated, sores that have not reminded of themselves for a long time "wake up". Allergies are no exception, and their symptoms may be more severe during pregnancy. One of the main symptoms of allergy is rhinitis. It can manifest itself not only by a runny nose, nasal congestion, but also by itching and other symptoms. Often women are prescribed antihistamines to relieve symptoms. Among them are Cetirizine, the instructions for the use of which we will now disclose.

In the instructions for the drug, as well as in numerous articles on the Internet dedicated to this drug, you can find that it is contraindicated during pregnancy. However, it is often prescribed for allergies in pregnant women, if the benefit from it is greater than possible risks... In the 90s of the last century, several studies were carried out, during which it turned out that the use of this drug even in the first trimester of pregnancy is permissible.

However, it is still an antihistamine that carries risks. Therefore, officially taking it during pregnancy and, and lactation is prohibited.

Instructions for using the drug

According to the instructions for use of Cetirizine tablets, the daily dosage for an adult is 10 mg. They can be taken immediately or divided into 2 doses of 5 mg. During pregnancy, the dosage can be selected individually, depending on the severity of the symptoms of allergy. This is all determined by the doctor, as well as the duration of the course of treatment.

In general, pregnancy itself is a contraindication to the use of this drug.... But, as is the case with most other drugs, in practice they are prescribed to pregnant women. In the vast majority of cases, no side effects or serious complications arise. Although, everything is individual and only the doctor decides in each case whether it is worth prescribing this drug or not. The drug should be used with caution in women with chronic renal failure.

How much do tablets, drops and analogues cost?

How much Cetirizine will cost depends on the form of release, the number of tablets or volume, dosage, country and manufacturer. For example, a package of Cetirizine with 30 10 mg tablets, produced in Russia, costs 152-190 rubles. The cost of a package of 20 tablets in the same dosage, but already produced in Macedonia, will cost 80-100 rubles. A package of the drug from a Vietnamese manufacturer with 10 10 mg tablets will cost 70-80 rubles. Swiss drops of Cetirizine in a volume of 20 ml will cost 250-270 rubles.

As for the analogues of Cetirizine, their cost is as follows:

• Cetrin - 162 rubles
• Zodak - 147 rubles
• Zirtek - 319 rubles

It must be remembered that not all analogues of the drug can be taken during pregnancy, in particular, the drug Loratadin can be found in the pharmacy, its use is possible only in extreme cases, when the life of the expectant mother is in danger. But all this must be discussed with your doctor in order to avoid any problems.

Allergy has long and firmly settled in modern world... No one is immune from the manifestations of this disease. During childbearing, allergies sometimes develop even in perfectly healthy women who have never experienced all the "delights" of this disease before. And the way out of the situation seems to them to be widely advertised and readily available antihistamines. Unfortunately, few pregnant women think about the danger of the usual Cetrin for the unborn child and the woman herself. This medicine can be prescribed only as a last resort, when there is no way to alleviate the condition of the pregnant woman by other means.

Allergies and pregnancy

After conception, women often develop new eating habits, and familiar foods can cause unusual reactions. Sometimes the expectant mother is prescribed medications or vitamin complexes that provoke her allergies. And if all this coincides with the flowering of some plants, then seasonal allergies are also added to the overall bouquet.

Difficulty breathing and annoying itching clearly do not make life easier, but it is very dangerous for a pregnant woman to relieve symptoms with some common drugs. For example, Cetrin can seriously harm a woman's health and poses a danger to the normal development of the fetus.

Allergic manifestations can be partially prevented with the help of careful attention to food and medicine. Seasonal allergies are also easier to tolerate with diet and healthy way life. This may not solve all problems, but self-medication is not an option. Sometimes the medicine can harm the pregnant woman more than the disease.

Important! It is impossible to use Cetrin to relieve allergy symptoms in pregnant women unless absolutely necessary. Only a doctor has the authority to prescribe this drug.

Fast-acting antihistamine

Cetrin is an antihistamine for allergy and itching symptoms. The medicine is prescribed for:

• allergic, chronic or seasonal rhinitis;
• conjunctivitis of allergic origin;
• itching and urticaria, including idiopathic (for an unknown reason).

The medicine prevents and relieves allergies. On the early stage disease Cetrin is able to almost completely suppress unpleasant symptoms. In more severe forms, the drug reduces inflammation, relieves spasms and tissue swelling. Almost no effect at recommended doses sedative effect.

Already after 20-60 minutes. after taking the Cetrin tablet, the effect of the active component is manifested. The effect lasts for a day, and after the cancellation or completion of the course, it persists for another three days.

Cetrin has not been clinically tested in pregnant women. There is no data on its effect on the formation and development of the fetus. It is extremely dangerous for expectant mothers to take the drug without consulting a doctor.

Important! The active component of the drug is able to penetrate the placenta and enter breast milk, therefore, it is dangerous to take Cetrin during pregnancy.

Pharmacological forms of Cetrin

The medicine is produced in several forms:

• white tablets in a dense shell;
• drops for internal use;
• syrup.

As part of one tablet of Cetrin:

• 10 mg cetirizine dihydrochloride (active ingredient);
• 106.5 mg lactose (milk sugar);
• 65 mg cornstarch (bulking agent);
• 2 mg of povidone K30 (enterosorbent, regulates the release of the active substance from the tablets, binds and removes toxins, does not enter the bloodstream);
• 1.5 mg magnesium stearate (bulking agent).

The shell consists of:

• 3.3 mg hypromellose (film coated);
• 0.66 mg macrogol 6000 (binds water in the digestive tract, stimulates peristalsis, prevents the loss of electrolytes);
• 0.706 mg titanium dioxide (food additive E 171, white dye);
• 1.183 mg talc (bulking agent);
• 0.05 mg sorbic acid (natural preservative, E 200);
• 0.05 mg polysorbate 80 (emulsifier);
• 0.05 mg dimethicone ( silicone oil, E 900).

In addition to 10 mg of cetirizine, the drops contain (per 1 ml):

• 250 mg glycerol (glycerin);
• 350 mg propylene glycol (preservative, E 1520);
• 7 mg sucralose (sweetener)
• 1.62 mg methyl parahydroxybenzoate (E 218, preservative);
• 0.18 mg propyl parahydroxybenzoate (E 216, preservative);
• 28.4 mg sodium hydrogen phosphate (additive E 339, emulsifier);
• citric acid monohydrate and water (about 360 mg).

In the Cetrin syrup, 1 mg of the active substance per 1 ml of the drug. Additional components of the syrup (per 1 ml):

• 100 mg glycerol;
• 450 mg sucrose (cane sugar)
• 1.5 mg benzoic acid (preservative, E 210 - E 213);
• 1 mg edetate disodium (an auxiliary component to improve absorption);
• 200 mg of seventy percent sorbitol solution (sugar substitute, E 420);
• 1 mg sodium citrate (stabilizer, E 331);
• 2.07 mg of flavor;
• water (about 240 mg).

If you look closely at the lists, it turns out that the tablets contain the most lactose, the drops contain the preservative and glycerin, and the syrup contains cane sugar. And this is not the main danger. The placental barrier is unable to delay the active component of Cetrin, which threatens the normal development of the unborn child.

Important! According to the instructions, during pregnancy and breastfeeding, Cetrin is prohibited in any pharmacological form.

How does Tsetrin work?

The active component of the drug - cetirizine - prevents or reduces certain biochemical reactions associated with the action of histamine (a mediator of immediate-type allergic reactions). It blocks the receptors that trigger the production of this substance, that is, it prevents or reduces:

• itching, hives;
• swelling of tissues;
• spasms of smooth muscles.

But histamine causes more than allergic reactions. He is involved in the regulation of vital processes. Usually this organic compound is in an inactive state, but under stressful, pathological situations, its release is activated.

Cetrin and pregnancy

During pregnancy, histamine is vital. At the beginning of gestation, he is responsible for the process of implanting an egg into the wall of the uterus. In later stages, this substance regulates the metabolism, the development of organs and tissues of the fetus. Taking Cetrin triggers a blockage of histamine and may disrupt the normal course of pregnancy.

In the first trimester, almost all medicines are prohibited. Even ordinary vitamins and some medicinal herbs can disrupt the subtle biochemical processes occurring at this time in a woman's body. Therefore, at the beginning of pregnancy, drinking Tsetrin is strictly prohibited.

At a later date, this medicine should not be taken without a doctor's prescription. Girlfriends advice and intrusive advertising cannot replace consultation with a specialist. Any antihistamines during gestation can harm an unborn child. Even if the woman's condition is very serious, self-administration of Tsetrin is dangerous - according to the reviews of pregnant women, the drug negatively affects the functioning of the liver and kidneys. Is temporary relief worth the risk of hurting yourself and your baby?

To suppress allergy symptoms, Cetrin blocks the action of histamine, but during pregnancy this can lead to impaired mental and physical development of the unborn child. Food or drug allergic reactions can be prevented by adjusting the diet or discontinuing drugs. Symptoms of seasonal rhinitis are relieved by others, more safe means... Prescribing Tsetrin to pregnant women is allowed only as a last resort, when other medicines do not bring relief.

The body of a pregnant woman reacts in a peculiar way to previously familiar products and phenomena. Therefore, it is not surprising that expectant mothers are prone to allergic reactions much more often than others: allergies manifest themselves in both mild and severe forms and depend on the use of certain drugs, the use of certain foods, or on a certain period of time when plants bloom or fruits ripen.

A natural desire to eliminate unpleasant symptoms and live full life pregnant women are trying to realize through antiallergenic drugs, but is it possible to use enough strong medicines, most of which have the ability to block histamine?

What is histamine and its role in the body of a pregnant woman

Besides the fact that histamine is a well-known mediator of allergic reactions, it is also an equally well-known regulator of physiological processes. In a pregnant body, histamine becomes a very important hormone, at the most early dates thanks to this component, the fertilized egg attaches to the wall of the uterus, and later histamine contributes to the normal development of the fetus and becomes the main regulator of metabolism.

The amount of histamine in the mother's body depends on how adequately the baby's tissues and organs will be formed.

Cetrin from a number of antihistamines

Which drug to choose for a pregnant woman with allergies? The first thing that comes to mind is Tsetrin. The medicine is effective, not very expensive, and advertising is placed in almost all mass media. But such an availability of the drug should, at least, make the expectant mother think and consult a doctor.

Only a specialist can dissuade women who are too keen on self-medication in the need for therapy with conventional drugs. During pregnancy, you need to switch to less aggressive and more appropriate medicines for the woman's current state.

Tsetrin is excluded from their number, but if other antiallergenic drugs do not help, doctors make an exception, prescribing Tsetrin to pregnant women, provided they are taken with great care and constant monitoring on their part.

Cetrin represents the second generation of antihistamines and differs from the first generation in that it has a softer effect on receptors and fewer side effects.

Composition, effects and pharmacokinetics of the drug

The active ingredient of Cetrin is cetirizine.

Excipients:

• lactose;
• magnesium stearate;
• povidone;
• corn starch.

The active substance at the cellular level binds to receptors and blocks the flow of histamine and prevents the manifestation of rash, itching, hyperemia.

Another feature of the drug's effect is to effectively counteract the accumulation of eosinophils in the inflammation focus and prevent the development of inflammatory process.

Cetrizin is absorbed from the gastrointestinal tract, and the meal regimen has practically no effect on absorption, so there is not much difference when to take the pill: before, after or during a meal.

Metabolic processes are concentrated in the liver, the half-life is from 5 to 12 hours, depending on the patient's age (the older he is, the longer the elimination is).

The drug is excreted in the urine.

Indications for use

Allergic reactions of a seasonal or chronic nature:

• allergic rhinitis;
• allergic conjunctivitis;
• itching of various adventures;
• hives;
• quincke's edema.

Pregnancy as a contraindication

In the instructions for the drug, pregnancy and lactation period are indicated by contraindications to the use of Cetrin. And any doctor will confirm that taking medications that suppress the effect of histamine in pregnant women can cause such negative consequences as impaired mental and physical development of the fetus.

As for the well-being of the mother, pregnant women taking Cetrin often complain about the negative effect of the drug on the functioning of the kidneys and liver.

Therefore, even if allergies are too painful, do not take the drug yourself - an easy decision can be very expensive later.

Tsetrin by trimester

1 trimester

Tsetrin is strictly contraindicated up to the 12th week of pregnancy. In the body of a pregnant woman during this period, such important processes, as the consolidation of the egg and the development of the embryo, therefore, it is impossible to reduce the level of histamine.

2 trimester

The development of fetal organs and systems is very active, as well as metabolic processes, allowing the baby to fully receive all the essentials from the mother's body. Histamine is involved in these processes, so blocking this component can lead to a loss of the baby nutrients and retarded development.

3 trimester

The baby's body is practically formed, but this is not a reason to take an undesirable drug for pregnant women. Tsetrin is prescribed only in exceptional cases and therapy is carried out under the strict supervision of a physician.

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Tsetrin during pregnancy: instructions for use, contraindications

Against the background of increased production of histamine, nasal congestion, lacrimation are observed, natural breathing is disrupted, there is a feeling of itching and burning in the paranasal sinuses. The development of side effects is highly undesirable during the period of gestation.

The therapeutic scheme of pregnant women includes sparing antihistamines of 3 generations, among which "Cetrin" is widely used. The active components are devoid of a cardiotoxic sedative effect, have a high selectivity, and are not addictive. Is it possible to drink "Cetrin" during pregnancy, and in what doses / course, so as not to harm the health of the baby and mother?

Feasibility of taking "Tsetrin" at different gestational periods

The drug is presented on the pharmacological market as syrup and tablets coated with a multicomponent soluble shell. Regardless of the form of release, the main composition forms a competitive histamine antagonist - cetirizine.

Find out here which drops can be used during pregnancy to restore nasal breathing.

The histamine receptor H1 blocker exhibits antipruritic, antiexudative and antiallergic activity. The therapeutic effect is enhanced by the presence of excipients in the composition: corn starch, lactose, povidone KZO.

"Tsetrin" relieves the symptoms of an allergic reaction, prevents the development of pathological changes in the influence of antigens. The action of the drug is aimed at inhibiting the synthesis of stimuli, reducing the cells of the leukocyte lineage, increasing the capacity of the capillaries.

The price range for tablets varies from 159 to 234 rubles

The components are quickly absorbed in the gastrointestinal tract, the medical effect occurs within an hour after ingestion, lasts up to 24 hours.

The productivity and safety of Cetrin is explained by the fact that it does not affect serotonin and cholinergic nerve endings. Studies that would prove the possible harm to the health of the mother and the unborn child have not been conducted on patients.

For reference! The constituent components can be excreted in milk during breastfeeding, therefore antihistamines are prohibited during lactation.

According to the instructions for the use of "Cetrin" during pregnancy, the drug is included in the therapeutic regimen at all stages of gestation, when the threat to the health of the mother and child exceeds the potential harm from taking the medication.

In order to prevent the risk of side effects, it is necessary to take an allergic drug according to the recommendations of a doctor and under medical supervision.

The minimum toxic effect on the fetus is exerted by the use of "Cetrin" in the 2nd trimester. Bookmark internal organs completed, the placenta is formed, the embryo is protected from the effects of the constituents of the drug.

Contraindications

Due to the fact that the drug is excreted from the body mainly by the kidneys, it is prescribed with caution to patients with a history of renal and liver failure.

For reference! In the therapeutic regimen of the elderly, "Cetrin" is included in a reduced dosage.

In pediatrics, the pharmaceutical product is approved from the age of six, mainly in the form of a syrup. With hypersensitivity of the body to individual components or overdose, the development of the following disorders is noted:

• headaches;
• signs of intoxication;
• depressive state;
• dizziness;
• increased blood pressure, tachycardia;
• tremors upper limbs;
• sensations of dry mouth.

Take the antihistamine with plenty of water

"Cetrin" during early pregnancy

After fertilization of the egg, the embryo formation period begins, which covers the first 13 weeks. At this time, the laying of organs and systems occurs. The multiplying cells of the fetus are sensitive to external factors impact.

The use of pharmacological products in the early gestational period is fraught with serious pathological disorders.

A weak placental barrier does not create hope of protection against the penetration of medicinal components, as a result - the development of fetal hypoxia, spontaneous abortion.

The ability of an antihistamine to affect the fetus determines the physiological characteristics of the patient and the state of the placenta, course and dosage.

Contraindications of "Tsetrin" during pregnancy in the 1st trimester indicate an increase in the likelihood of side effects, but this does not mean that pathological changes are characteristic for each clinical case.

Therefore, in order to prevent the risk of defectiveness of the unborn child, it is advisable to show increased concern for your health and the baby in order to eliminate the need for drug treatment.

Method of administration and dosage

Widespread in ENT practice is the tablet form of the release of an antiallergic product. 1 tablet contains 10 mg. cetirizine dihydrochloride. This is a one-time norm for adults. With reduced renal function, the dose is halved - half a tablet (5 mg). The daily rate is limited to two steps.

For reference! In chronic renal failure, "Cetrin" is prescribed at 5 mg. in one day.

The duration of the drug regimen determines the form of the lesion, the etiology of the pathogen, the general course clinical picture... For prophylaxis, the course of application varies from 2 weeks to a month.

For therapeutic purposes, it is prescribed in a cycle from 14 days to six months. Medicinal effect persists for the next 3 days after discontinuation of the drug.

Self-medication with the manifestation of allergic symptoms is categorically contraindicated throughout the gestational period

The digestion process does not slow down the period of absorption of the active components, therefore, it is allowed to use tablets before or after meals, drinking plenty of water.

The scheme for taking the liquid form does not differ from the previous variation. From the age of twelve, 10 ml is prescribed. syrup twice a day, provided that there are no pathological disorders from the kidneys.

Conclusion

Before using "Cetrin" it is recommended to study the annotation in order to prevent the development of side effects. The 3rd generation antihistamine exhibits a high therapeutic effect in a gentle form for allergic rhinitis, conjunctivitis, hay fever, dermatosis, complex therapy with bronchial asthma.

The minimum risks of developing side effects from the use of the drug are observed in the 2nd trimester of pregnancy. Therefore, early and late periods are contraindications for the appointment.

gorlonos.com

Tsetrin: indications for use, analogues

Hello friends! Today I want to tell you about the drug cetrin, whose indications promise to cope with allergies.

It's not a secret for anyone that there are a lot of drugs that stop allergic attacks, but I want to tell you about this remedy: its advantages and disadvantages.

In the next article, by the way, you can read what cetrin tablets are prescribed for.

Tsetrin indications for use

Previously, I consider it necessary to write 2 medical facts:

1. Any irritants, getting inside, meet with a powerful rebuff from immune cells.
2. There are situations when immunity weakens and then control over the production of histamines disappears: they begin to form in huge quantities, and have a detrimental effect on all human tissues and organs.

Antihistamines come to the rescue in such situations. Today, three generations of antihistamines are used in clinical practice. The first generation includes:

• tavegil,
• fenistil,
• diazolin

Reading the indications for the use of each of them, one can come to the conclusion that they all have a powerful suppressive effect.

But, unfortunately, this affects the manifestation of an equally strong side effect - drowsiness.

Third-generation drugs (claritin, telfast, erius) have the same strong properties in suppressing the production of histamine, and are practically free of side effects.

And what are the specific indications for use of cetrin?

It belongs to the second generation of antihistamines and has a broader spectrum of action. It does not have a very pronounced side effect, but it also acts on the receptors more gently.

The active ingredient - cetirizine, binds to receptors, and does not allow histamine to them. This means that such allergic manifestations are blocked as:

And this happens already at the cellular level. In addition, it does not allow eosinophils to accumulate in the focus of inflammation, and, accordingly, prevents the development of the inflammatory process at the site of the allergic reaction.

Due to such qualities and indications, it can be prescribed for the treatment of allergies not only for adults, but also for children over 2 years old.

Let's now try to figure it out: what is said in the indications for use about pregnancy ...

Cetrin during pregnancy

Before talking about the possibility of its use during pregnancy, I want to tell you: why, in general, antihistamines are forbidden to be taken by expectant mothers.

During pregnancy, histamine becomes an essential ingredient. With its assistance, the fertilized egg is attached to the wall of the uterus.

It promotes the development of the embryo, and further regulates the metabolism of the fetus. The formation of tissues and organs of the baby depends on it.

Important to remember!

Taking drugs that suppress the production of histamine can tragically affect the condition of the child, his physical and mental development.

Here are the indications for use of cetrin during pregnancy:

if you start using it, it can negatively affect the functioning of the kidneys and liver. Therefore, cetrin during pregnancy has, of course, advantages over other drugs, but it is used with great caution.

MANDATORY, you need to consult with a local specialist, and then, if you are allowed to use it, do it under the strict supervision of a doctor.

The drug has few side effects and does not affect the quantitative production of histamines.

But, nevertheless, during the first 12 weeks, its use is generally prohibited. And in the future, doctors look at the state of health of the mother and fetus.

It is also worth saying that the medicine is produced by an Indian pharmaceutical company, but are there analogues in domestic production?

Tsetrin analogs

Comparing what cetrin has indications for use and looking through reference books, I found a number of domestically produced medicines that are similar in their action.

All dosage forms, produced on the basis of cetirizine, and being histamine blockers can be considered analogs.

Therefore, here are the analogs of cetrin:

• Fesco pills,
  • Ceresa,
  • Ketotifen,
  • Clarifer,
  • Ksizal,
  • Telfast.
  • Klargotil syrups,
    • Claridol,
    • Loratadin,
    • Peritol.

If we compare in general the indications for the use of some other drugs, which are sometimes called "synonyms", this is another separate list.

This includes all drugs based on cetirizine, and slightly different additional components.

• Alerza,
• Cetirizine,
• Letizen,
• Zyrtec.

The list can be continued for a very long time. Now, knowing what cetrin has indications for use, you must decide: do you want to start using it?

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Antihistamines during pregnancy

No one is happy about allergies. And during pregnancy, it is also fraught with danger. This often happens to women who are naturally prone to allergic reactions. But if earlier they used the drugs that suit them best, then with the onset of pregnancy everything changes dramatically. So, let's find out how to save future mothers? What antihistamines are they allowed?

Features of allergy during pregnancy

Such a reaction can also occur in those women who have not previously suffered from allergies. And this is due to a change in work immune system... If the expectant mother is allergic by nature, then allergic manifestations can be expressed in varying degrees - from mild to very severe. Their main types in pregnant women are:

1. Rhinitis. This is the most common symptom that can occur from the second trimester.
2. Conjunctivitis. In most cases, it is combined with rhinitis.
3. Contact dermatitis or eczema. The latter is a thickening and swelling of the epidermis, its redness, itching.
4. Hives. In severe cases, it can develop into Quincke's edema.
5. Signs of bronchial asthma. The risk of its exacerbation increases at the end of the second trimester.

Allergy of the expectant mother is the risk of fetal hypoxia after vasospasm of the placenta vessels. The reasons for its manifestations are seasonal phenomena, the use of food allergens, contact with household chemicals, other negative impacts.

About the types of antihistamines

Today there are three generations of them. These drugs have the same principle of action. But the difference lies in the attachment of drug molecules to receptors in the body.