Maaloks reception. Maalox: Indications for use, how to take

Maalox: instructions for use and reviews

Latin name: Maalox.

ATX code: A02AD01

Active substance: Algeldrat + Magnesium Hydroxide (Algeldrate + Magnesium Hydroxide)

Manufacturer: Pharmatis (for Laboratoire Theraplix) (France), Sanofi-Aventis S.P.A. (Italy)

Actualization of the description and photo: 14.08.2019

Maalox is an antacid agent.

Release form and composition

Dosage forms:

• Chewable tablets: round flat cylindrical shape, white color, with chamfer and engraving "MX" (10 pcs. in blisters, in a cardboard pack 1, 2 or 4 blisters);
• Suspension for reception inside: liquid resembling white or almost white liquid, with mint smell (250 ml in glass bottles of dark color, in a cardboard pack of 1 vial; 15 ml in bags (sachet), in a carton of 30 bags).

The actors of Maalox:

• Algelfrart (in the form of aluminum hydroxide): in 1 tablet - 0.4 g (equivalent to 0.2 g of aluminum oxide), in 100 ml of suspension - 3.5 g;
• Magnesium hydroxide: in 1 tablet - 0.4 g, in 100 ml of suspension - 4 g.

Auxiliary components:

• Tablets: sodium saccharinate, starch with sucrose (sugar confectionery), sucrose, sorbitol, magnesium stearate, mannitol, peppermint flavoring
• Suspension: sodium saccharinate, hydrochloric acid concentrated 10%, peppermint leaf oil, monohydrate, hydrogen peroxide 30%, methyl aprichedroxybenzoate, mannitol, propyl aprichedroxybenzoate, sorbitol 70%, purified water.

Pharmacological properties

Pharmacodynamics

Maaloks neutralizes unrelated hydrochloric acid, while not leading to the secondary hypersecretion of this connection. Its reception contributes to increasing the pH, which causes a decrease in the peptic activity of the gastric juice. For the preparation, it is also characterized by an enveloping and adsorbing effect, as a result of which the effect of damaging factors on the mucous membrane decreases.

Pharmacokinetics

Algelfrart (aluminum hydroxide) and magnesium hydroxide are local antacids and are practically not absorbed when taking therapeutic dosesSo there are no systematic effects when using Maalox.

Indications for use

• Exacerbation peptic disease Stomach I. duodenal gut;
• Aggravation of chronic gastroduodenitis with a normal or elevated secretory function;
• Gastroduodenitis B. acute shapese;
• Reflux-esophagitis;
• Treatment and prevention of dyspeptic phenomena arising against the background of the use of glucocorticosteroids, non-steroidal anti-inflammatory drugs and other medicines;
• Hernia of the esophageal hole of the diaphragm;
• Heartburn, discomfort or epigastric pain, sour belching, arising from excessive use of alcohol, coffee, nicotine or errors in a diet.

Contraindications

For tablets:

• Increased sensitivity to the components of the drug;
• Heavy renal impairment.

For suspension:

• Glucose-galactose malabsorption, shortage of sugar or isomaltase, fructose intolerance;
• Pronounced renal failure;
• Hypophosphatemia;
• Age up to 15 years.

Under the regular observation of the doctor, a suspension of Maalox should be used: patients with impaired kidney function (since there is a risk of increasing plasma concentrations of aluminum and magnesium, and a long-term reception in high doses (including high therapeutic doses) can cause the development of dementia, encephalopathy, microcitar anemia); Patients with porphyria located on hemodialysis; Complying with a low phosphate diet (the risk of phosphate failure).

According to the instructions, Maalox with caution should be prescribed in both dosage forms to patients with Alzheimer's disease; During pregnancy and breastfeeding.

Maalox application instructions: Method and dosage

Maalox tablets take inside, cheerfully chewing. Recommended dosing: 1-2 tablets are 3-4 times a day 1-2 hours after meals and before bedtime. With reflux-esophagitis, the break between the food and reception of the tablets should be reduced. Course of treatment for no more than 2-3 months. For episodic use, a single reception of 1-2 tablets is shown;

Maalox suspension is designed to receive inside in undisguised form. The preparation in the bag should be pre-thoroughly stretched with fingers. Recommended dosing for adults and children over 15 years old: 15 ml 1-2 hours after each meal and in the event of heartburn or pain in the epigastria. Maximum daily dose - no more than 90 ml. With reflux-esophagitis, the suspension should be taken after 0.5-1 hours after eating, ulcerative stomach disease - 0.5 hours before meals. Course of treatment for no more than 2-3 months. With episodic reception associated, for example, with discomfort after errors in a diet - 15 ml once. Patients with impaired kidney function can not be prescribed a drug for a long period and / or high doses.

Side effects

• Tablets: With a violation of the kidney function and / or on the background of long therapy - an increase in the content of magnesium and / or aluminum in blood plasma, encephalopathy, lack of phosphorus in the body, exacerbation of Alzheimer's disease and bone-muscular pathologies in senior patients;
• Suspension: rarely - diarrhea; With long-term use of high doses - hypophosphatemia (more often at low phosphate diet), nephocalcinosis, hypercalciuria, hypocalcemia, osteomalacia, osteoporosis, kidney functional disorder. If the kidney function is impaired: it is possible - hypherthexia, an increase in the level of plasma concentrations of aluminum and / or magnesium, the development of a feeling of thirst, a decrease arterial pressure; Rarely - with long taking high doses, dementia, encephalopathy, microcolitan anemia is possible.

In addition, in rare cases, the use of Maalox causes disorder digestive system In the form of a change in taste sensations, nausea, constipation, vomiting.

Overdose

The symptoms of acute overdose associated with the reception of the drug comprising a salt of magnesium and aluminum hydroxide include vomiting, diarrhea and pain in the abdomen. In patients who are in the risk group, the introduction of Maalox in high doses can provoke or contribute to the exacerbation of such states as intestinal obstruction Either intestinal obstruction.

Since magnesium and aluminum are derived through the kidneys, treatment of acute overdose includes the replenishment of fluid deficit and forced diuresis. Patient S. renal failure It is recommended to carry out peritoneal dialysis or hemodialysis.

special instructions

If the kidney function is violated, the drug should be prescribed with caution.

If you need to assign Maaloks Tablets to children under 12, the dispensing mode should be established individually, according to clinical indications.

When preserving the symptoms or deterioration of the state from the gastrointestinal tract after 10 days of suspension reception, you should contact a doctor to clarify the diagnosis and correction of therapy.

The use of the drug in adolescents, during pregnancy and breastfeeding, as well as with renal failure, easy and middle degree Severity should be started only after the consultation of the doctor.

Since the effect of algeldrat at a low-phosphate diet can contribute to the development of phosphorus deficiency in the body, it is recommended to provide a patient with rich phosphates, especially with long therapy.

Maalox does not affect the ability of patients to management vehicles and mechanisms.

Application during pregnancy and lactation

In the results of animal studies, there are no clear guidance on the likelihood that aluminum hydroxide and magnesium hydroxide have a teratogenic effect. Today, specific teratogenic effects when using Maalox during pregnancy, they are not identified, but due to insufficient clinical experience, its appointment for pregnant women is possible only in cases where the potential benefit of treating for the mother significantly exceeds the possible risks for the fetus.

Medicinal interaction

In case of non-compliance with the two-hour break between the reception, Maalox tablets reduce the suction of the following simultaneously used drugs: tetracyclines, acetylsalicylic acid (and other salicylates), atenolol, propranolol, metoprolol, difloinisal, chlorohin, digoxin, Blocators H 2 -Gistamine receptors, Bisphosphonates, sodium fluoride, isoniazid, ethambutol, quinolones, corticosteroids (described for dexamethasone and prednisolone), lansoprazole, indomethacin, lincosamides, ketoconazole, sodium levothyroxine sodium polistirolsulfata, iron salts, penicillamine, phenothiazine antipsychotics, fexofenadine, phosphorous dietary supplements.

To avoid unwanted interaction of the drug with fluoroquinolones, a break in the reception should not be less than 4 hours.

When combined with quinidine, it is possible to increase the level of its blood serum concentration, which can cause an overdose of quinidine.

Against the background of the urine sickling under the action of Maalox, while using salicylates, there is an increase in their excretion with urine.

Concomitant citrate therapy can contribute to an increase in the level of aluminum concentration in blood plasma, especially in patients with renal failure.

Analogs

The analogues of Maalox are: Adzhiflyux, Alumag, Almaty, Almol, Almaty Neo, Altacid, Anazid Forte, Palmagel, Maaloks Mini, Gastracide, Malukol, Rivolox, Phosfalugel.

Terms and conditions of storage

Store at temperatures up to 25 ° C. Take care of children.

Shelf life: Chewable tablets - 5 years, suspension for intake - 3 years.

Antacid agents are prescribed antacid drugs with pains in the stomach and other uncomfortable symptoms caused by too high acidity. These include the drug called Maalox. Is it possible to give this medication to children and in which dosage it is allowed in childhood?

Release form and composition

Maalox is represented by two dosage forms:

• Suspension.It is produced in glass bottles, inside of which there are 250 ml of the dying homogeneous opaque substance of white and yellow or white. In addition, the suspension is produced in 15 ml portioning sachets, which contains 30 pieces in one box.

• Chewing pills. Such Majoks is produced in two versions - without sugar (these pills are in demand when sugar diabetes Or a strict diet) and with sugar. These tablets round shape and engraving. The drug without sugar is distinguished by yellowish or white painting with a slight marble, as well as lemon smell. Tablets with sugar white and smell like mint. One box contains 10, 20 or 40 tablets.

Both types of drug include two active components:

• Algelfrart.This compound is a hydrated aluminum oxide and is contained in a single chewing tablet at a dose of 400 mg, and in 15 ml of suspension - in an amount of 525 mg.
• Magnesium hydroxide.Such an ingredient is represented in each tablet with a dosage of 400 mg, and from 15 ml of suspension, the patient receives it at a dose of 600 mg.

Additionally, the suspension contains citric acid, mannitol, mint oil, sorbitol and other ingredients. The auxiliary substances of the tablets are mannitol, sucrose, mint flavor, sodium saccharinate and other substances.

Separately, we note the preparation of Maaloks mini. It is represented by portion bags of 4.3 ml of suspension, which contains 460 mg of aluminum hydroxide and 400 mg of magnesium hydroxide. One box contains from 6 to 40 bags. The taste of the drug is lemon or black-cormoodine.

Operating principle

Maalox represents a group of antacid agents and has an enveloping, as well as an absorbent action. Its use reduces the acidity of gastric juice and prevents the negative effect on the gastric mucosa of hydrochloric acid.

Indications

Maalox is prescribed with different diseases digestive tractwhich are manifested by discomfort in the abdomen, belonging to acidic, heartburn, pain in the stomach and other symptoms. Medication in demand:

• With exacerbation of ulcerative disease.
• With acute gastroduodenitis.
• When aggravating the chronic form of gastritis or gastroduodenitis.
• With reflux-esophagitis.
• With hernia, the diaphragm (esophageal opening).

In addition, Maalox is used in dyspepsia, a disruption of a diet, drug intake and other factors. Maaloks mini apply only episodically to eliminate heartburn or belching.

From what age are prescribed?

In the instructions for both suspensions and tablets, Maalox and to the preparation of Maalox mini, it is noted that such medicines are contraindicated to children under 15 years old. This is due to insufficient clinical research The impact of such funds on children's organism. In practice, doctors often discharged it to children, calling relatively safe.

At the same time, the treatment of children by Maalox should be under the control of pediatrician and non-plum (no more than 1 month) to prevent the loss of calcium and phosphorus. In addition, in childhood, only a suspension is used, after all, it is difficult to solve or december a tablet to a child.

Contraindications

The drug does not apply:

• With severe renal failure.
• With the intolerance of any of its component.
• During problems with the assimilation of fructose, sucrose or galactose.

Side effects

In some patients, Maalox causes constipation, but sometimes it provokes a chalk thinning. In addition, the medicine may cause urticaria, skin itch and other manifestations of allergies.

Instructions for use

The bottle of suspension is advised to shake up before use, and the bag is to stretch with fingers. The contents of the Sasha is taken undressed, and the preparation from the bottle is dosed with a spoon (one tablespoon accommodates 15 ml of syrup).

A single dose of medication for a child under year is half a teaspoon (2.5 ml), for children 1-5 years old - a complete teaspoon (5 ml), for a patient aged from 5 to 15 years old - one tea or one dessert spoon ( 5-10 ml). If the remedy is assigned to the course, then it is usually taken twice or three times a day.

Tableted Maalox should be chewed or dissolved after one or two hours after meals, as well as at night. The drug is discharged by children over 15 years old 1-2 tablet on reception. Usually it is prescribed three times, but sometimes the doctor can recommend a reception 4-6 times a day. The duration of treatment in chronic pathologies is up to 2-3 months.

Overdose and Medicinal Interactions

Excess dose of the drug leads to diarrhea, abdominal pain or vomiting. For treatment, it is recommended to give more fluid to allow magnesium and aluminum to leave the patient's body faster.

The reception of Maalox reduces the suction in the intestine of many other drugs, so there is a pause of at least 2 hours between the use of such a means and any other medicines.

Terms for sale and storage

All kinds of Maalox, including portion bags, are sold without a recipe. average price The bottle of suspension is 320-350 rubles, and packages of 20 chewing tablets are approximately 220-240 rubles.

Store medicine at home is advised at room temperature in hidden from small children. The shelf life of pills with sugar is 5 years, and other forms of medication - 3 years.

A revealed bottle of suspension can be stored no longer than 6 months after the first use of the medication.

Maalox - medicationwhich has a mixed impact that is characterized by antacid, choleretic, enveloping, wind turntable, adsorbing actions that has a beneficial effect on the functions of the stomach and esophagus.

The drug returns a patient to the familiar comfort and ability to re-enjoy the joys of life. It should only be used according to the instructions and on the recommendation of the doctor, although on sale without a recipe.

Clinical and Pharmacological Group

Antacid drug.

Conditions of vacation from pharmacies

Released without a doctor's prescription.

Prices

How much is Maalox? The average price in pharmacies is at 450 rubles per suspension, and 200 rubles per pill.

Release form and composition

Release the following medicinal forms Maalox:

• Chewable tablets: flat, white, with beveled edges, round, with MX engraving on one side (in blisters of 10 pcs.; 1, 2 or 4 blisters in a pack of cardboard);
• Chewing tablets (without sugar): round, with chamfer, flat-cylindrical, with lemon smell, from white to yellowish color with a slight marble, with "SANS SUCRE" engraving on one and "Maalox" on the other side (in blisters of 10 pcs; 1, 2 or 4 blisters in a pack of cardboard);
• Suspension: white or practical white color (reminiscent of milk), with smell of mint (in dark glass vials 250 ml, 1 bottle in a pack of cardboard; in Sasha 15 ml, 30 sachets in a pack of cardboard).

Composition 1 chewing tablets (without sugar):

• Active substances: Magnesium Hydroxide - 0.4 g, Algelflerat in the form of aluminum oxide hydrated - 0.4 g (corresponds to the alumina content of oxide - 0.2 g);
• Auxiliary Components: Talc, Malthitol, Glieceol 85%, sorbitol Liquid (uncritical), magnesium stearate, sodium saccharinate, aroma lemon (acacia gum (E414), flavoring preparations, butylhydroxyanisole (E320), citric acid (E330), natural flavoring agents) .

Composition 1 chewing tablets:

• Active substances: magnesium hydroxide - 0.4 g, aluminum hydroxide - 0.4 g;
• Auxiliary components: sodium saccharinate, starch with sucrose (sugar confectionery), magnesium stearate, sucrose, sorbitol, peppermint fragrance, mannitol;

In 15 ml of suspension produced in Sasha, contains:

• Active substances: Magnesium hydroxide in the form of gel - 0.6 g, algelfland in the form of aluminum hydroxide - 0.525 g;
• Auxiliary components: hydrogen peroxide 30%, hydrochloric acid concentrated, citric acid monohydrate, sorbitol 70%, peppermint leaf oil, sodium saccharinate, mannitol, propyl apricsibenzoate, methyl aprichedroxibenzoate, purified water.

In 100 ml of suspension produced in vials, contains:

• Active substances: Magnesium hydroxide - 4 g, algelfrart in the form of aluminum hydroxide - 3.5 g;
• Auxiliary components: hydrogen peroxide 30%, hydrochloric acid 10%, citric acid monohydrate, sorbitol 70%, oil of peppermint leaves, sodium saccharinate, mannitol, propyl apricinoxibenzoate, methyl aprohydroxybenzoate, water purified.

Pharmacological effect

The active components of Maaloks - magnesium hydroxide and algelfrarat - affect the free hydrochloric acid of the gastric juice, neutralizing it without the effect of secondary hypersecretion. The use of the drug contributes to an increase in the pH level of the gastric juice, thereby reducing the activity of the pepsin contained in it. In addition, Maalox has an enveloping and adsorbing effect, reducing the influence of various damaging factors on the mucous membrane of the stomach and esophagus.

Magnesium and algeldrat hydroxide are antacid substances of local action, which have low absorption, that is, not absorbed into the blood in large quantities. Due to this, Maalox is considered a drug that does not provide systemic effects on the body.

What Maalox helps: indications for use

Suspension and Tablets Maalox have such indications for use:

• dyspepsic manifestations - heartburn, pain and unpleasant sensations in the stomach, belching with deviation from a diet, excessive consumption of alcohol, smoking;
• attacks of constant peptic diseases of the epigastria and duodenum;
• chronic and acute forms with increased or normal discharge in the aggravated period.

Contraindications

Maalox should not be taken:

• with severe renal failure;
• with hypophosphatems;
• under the age of 15;
• with increased sensitivity to components included in the drug;
• in the event of a deficiency of isomaltose / sacrament, fructose intolerance and glucose-galactose macabsorption.

Maalox needs to be taken with caution:

• in Alzheimer's disease;
• during pregnancy and breastfeeding;
• patients with porphyria that are on hemodialysis;
• with a low content of phosphates in food (in order to avoid the development of phosphate failure);
• in disruption of the kidney function (in such patients, when taking the drug, it is possible to increase the concentration of aluminum and magnesium, with long-term use of Maalox in large dosages, the development of dementia, encephalopathy and microcolitical anemia is possible.

Use during pregnancy and lactation

The drug is contraindicated to use in the first trimester of pregnancy, since the clinical tests of the tablets were not carried out and it is not known how safe this means for the development of the fetus in the womb.

In the second and third trimesters of pregnancy, treatment can be carried out only by strict testimony, under the control of the doctor, the shortest possible time. To eliminate heartburn to future mothers, it is recommended to consult a doctor to select an alternative and secure agent.

During the period of breastfeeding, the treatment of the drug is possible only by appointing a doctor, while it is very important to monitor the toddler's reaction to the drug, since the active active ingredient is distinguished with breast milk.

Dosage and method of application

In the application instructions, it is indicated that Maaloks is designed to receive inside only by persons over 15 years old.

Suspension in bags

Before applying, a suspension in the bag should be homogenized, thoroughly warm it between the fingers. The contents of the bag is accepted in a unwanted form.

• Maalox takes 1 sachet with a suspension (15 ml) usually 1-2 hours after meals and at night, as well as when pain in epigastrics or heartburn. The daily dose should not exceed 6 bags (90 ml of suspension per day).

With reflux-esophagitis, the drug takes 30-60 minutes after meals.

With ulcer of the stomach, the drug is taken 30 minutes before meals.

Suspension in bottles

Before applying the bottle should be shaken.

• Assign 15 ml (1 tablespoon) 3-4 times a day after 1-2 hours after meals and at night. The dose should not exceed 6 tablespoons per day.

With reflux-esophagitis, the drug takes a short time after meals.

• The course of treatment should not exceed 2-3 months.

With episodic application, for example, with discomfort after errors in the diet, 15 ml is taken once.

In patients with impaired kidney function, the use of the preparation of Maalox in high doses and / or for a long time should be avoided.

Pills

Maalox tablets should be dissolved or cheerfully chew.

• Assign 1-2 tab. 3-4 times / day after 1-2 hours after meals and at night.

With reflux-esophagitis, the drug is accepted after a short period of time after meals.

Maximum multiplicity of reception - 6 times / day. Do not take more than 12 tab. / Day.

• The duration of reception should not exceed 2-3 months.

In case of episodic application, for example, at discomfort after errors in the diet, 1-2 tab is taken. once.

Side effects

All varieties and dosage forms Maaloks and Maalox mini can provoke the same following side effects:

1. Reactions from digestion: diarrhea, constipation.
2. Reactions from side immune system: Anaphylactic reactions, urticaria, itching, angioedema swelling.
3. The reactions from metabolism: hyperauluminimia, hypermagniamia, hypophosphatemia (with long-term therapy or reception in large doses, with a low phosphate concentration in food) capable of enhanced bone resorption, osteomalysis, hypercalciuria.

Use the drug in pediatrics with extreme caution. Dose is selected individually. Purpose of dosages and reception frequencies are prescribed only by the attending pediatrician. Large dosages and long-term use are excluded.

Overdose

The excess of the recommended instruction of the daily or one-time dose of the drug may result in serious consequences - the appearance of pain in the abdomen, diarrhea and vomiting. In patients with risk group (renal failure and elderly age) Its constant consumption can strengthen the obstruction and obstruction of the intestine. In large doses, the drug is able to adversely affect even the health of people who have only a predisposition to the development of phosphate deficiency.

When symptoms appear an overdose, it is worth stopping medication immediately and wait until magnesium and aluminum be withdrawn along with urine. In addition, it is necessary to conduct a forced diurea by the adoption of diuretics. And patients with kidney diseases are carried out peritoneal dialysis and hemodialysis for blood purification.

special instructions

Before you start using the drug, familiarize yourself with the special instructions:

1. The 2-hour interval should be observed between the use of the preparation of Maalox and other drugs.
2. If during the treatment of the symptoms from the heading of the gastrointestinal tract for more than 10 days or the deterioration of the state is observed, then the diagnosis should be clarified and conduct a correction of therapeutic measures.
3. When prescribing the preparation of Maaloks to patients with renal failure of light and moderate severity, it is necessary to carefully monitor plasma concentrations of aluminum and magnesium, and if they enhance them, the use of the drug should be immediately discontinued.
4. Algelfrart with low phosphate content in food can lead to the development of phosphorus deficiency in the body. Therefore, when applied, especially long, it is necessary to ensure sufficient flow of phosphates with food.

Despite the fact that the drug is released without a recipe, before applying the drug during pregnancy and lactation (breastfeeding), as well as in adolescents and patients with renal failure of light and moderate severity, it is recommended to consult with the doctor.

Medicinal interaction

With simultaneous use with quinidine, it is possible to raise serum concentrations Cynidine and the development of overdose of quinidine.

With the joint use of the preparation of Maalox with polystyrenesulfonate (kayeksalat), caution should be taken due to possible risk Reducing the efficiency of potassium binding resin and the development of metabolic alkalosis in patients with renal failure (for aluminum hydroxide and magnesium hydroxide) and intestinal obstruction (for aluminum hydroxide).

With simultaneous reception with the drug Maalox decreases suction from the tract of the following drugs: histamine H2 receptor blockers, propranolol, atenolol, cefidinira, cefpodoxy, metoprolol, chlorohin, prostacycline, difluorizala, digoxin, bisphosphonates, etcutol, isoniazide, fluoroquinolone, sodium fluoride, GKS (Described for prednisolone and dexamethasone), indomethacin, ketoconazole, lincoosamide, neuroleptics derivatives of phenothiazine, penicillamine, rosuvastatin, iron salts, levothyroxine sodium. In the case of a 2-hour interval between the reception of these drugs and the preparation of Maalox and the 4-hour interval between the taking of fluoroquinolones and the preparation, Maalox in most cases of this undesirable interaction can be avoided.

With a combination of aluminum hydroxide with citrates, an increase in plasma concentrations of aluminum is possible, especially in patients with renal failure.

Maalox (Maalox) is an antacid drug with adsorbing and enveloping effect, due to which the impact of damaging factors on the mucous membrane of the esophagus and the stomach decreases. The listed mechanisms protect the mucous membrane from damage to chemically aggressive components.

Composition and form of release

Maalox is tradename Popular combined drugBased on which hydroxides: magnesium and aluminum, the latter is called algelflend. The composition of one packet of a suspension (15 ml). Active substances:

• Magnesium hydroxide 600 mg
• Aluminum hydroxide 525 mg
• Excipients:
• Concentrated chloride hydrochloric acid 0.018 ml
• Lemon Acid Monohydrate (EZZO) 9.82 mg
• Peppermint essential oil 1.89 mg
• Mannitol (E421) 37.50 mg
• Methylpagidroxybenzoate (E218) 15.00 mg
• Propilepagidroxybenzoate (E216) 7.50 mg
• Sodium saccharinate (E954) 4,215 mg
• Sorbitol 70% (non-exclusive) (E420) 214.3 mg
• Hydrogen peroxide 30% (9.75 mg)
• Purified water up to 15 ml.

Manufacturer	Aventis Pharma S.P.A., Italy ( chewing tablets and suspension, vial 250 ml) and Farmatis, France (suspension, 15 ml bag).
Active substance	Algelfrart (in the form of aluminum hydroxide): in 1 tablet - 0.4 g (equivalent to 0.2 g of aluminum oxide), in 100 ml of suspension - 3.5 g; Magnesium hydroxide: in 1 tablet - 0.4 g, in 100 ml of suspension - 4 g.
Form release	Currently, there are two varieties of this drug - this is: Maalox tablets: White plane-cylindrical tablets for chewing round shape with engraving "MX". 10 pills in the blister. 1, 2 or 4 blisters in a pack of cardboard. The suspension is a white liquid with a smell of mint reminiscent of milk. 15 ml of suspension in sachet - 30 bags in a pack of cardboard. 250 ml in a glass bottle is one bottle in a pack of cardboard.

pharmachologic effect

Therapeutic effects and action of Maalox are due to the composition of magnesium hydroxide and hydroxide aluminum. The mixture of these components is usually called aluminum-magnesium-hydroxide (AMG). So, AMG has the following therapeutic effects:

• Antacid;
• Adsorbing;
• Enveloping.

The drug neutralizes free hydrochloric acid, without causing secondary hypercelling of hydrochloric acid. Due to the increase in the pH, the peptic activity of the gastric juice is reduced. It also has an adsorbing and enveloping effect, due to which the impact of damaging factors on the mucous membrane decreases.

Indications

What does Maaloks and his substitutes help? And Maalox, and most drugs replacing it have a large number of positive therapeutic effects:

• adsorbing;
• enveloping;
• choleretic;
• antacid.

The big plus of this means is that it is practically not absorbed into the blood, and, therefore, has an exceptionally local action.

The drug instructions indicate that the indication for the use of Maalox is:

• ulcerative ulcer of the stomach and duodenal intestine in the aggravation phase;
• acute or chronic gastroduodenitis, with a normal or increased secretory function in the aggravation phase;
• , reflux-esophagitis;
• dyspeptic phenomena, such as discomfort or epigastric pain, heartburn, sour belching after errors in the diet, excessive use of ethanol, coffee, nicotine
• dyspeptic phenomena, such as discomfort or epigastric pain, heartburn, sour belching (and their prevention) resulting from the use of some LS (NSAID, GKS).

Preparation Maalox may also be assigned to patients in the composition complex therapy When dyspepsia, accompanied by rotten processes in the intestines, sluggish motility, stagnant processes in the bustling bubble.

Instructions for use

Tablets need to be dissolved or thoroughly chew in the oral cavity, and only after that swallow. If saliva is a bit generated, then after chewing or resorption, you can put a tablet with several sips of pure non-carbonated water.

How to take the drug? Maaloks. Take us usually 1-1.5 h after eating Or when pain.

Maalox tablets and suspension are designed to treat patients in age over 15 years.

Tablets Maalox

Tablets: take inside, cheerfully chewing. Recommended dosing: 1-2 tablets are 3-4 times a day 1-2 hours after meals and before bedtime. When a break between food and taking tablets should be reduced. Course of treatment for no more than 2-3 months. For episodic use, a single reception of 1-2 tablets is shown.

Maaloks in suspension

Suspension: The suspension takes 15 ml (1 package). Before use, the suspension is homogenized, carefully a warm-up package between the fingers. The contents of the package squeeze into a spoon or mouth.

How to take Maalox with errors in a diet? Usually, coursework is not required, 1 package or 15 ml of means is enough. As preventive measure It is enough to drink 5-10 ml of suspension before eating. In the form of tablets, one reception requires 2-3 tablets. The dose can be increased to 3-4 tablets if necessary.

It is important to say that the nuances of receiving this funds must be stipulated with the attending physician, which individually comes to each patient and a separate clinical case.

Contraindications

• Increased individual sensitivity to the components of the drug;
• Chronic renal failure;
• Age of children under 12 years due to lack of clinical trials;
• Pregnancy period in 1 trimester;
• Alzheimer's disease;
• Hypophosphatemia.

In the manual for Maaloks it is indicated that: It is necessary to use medicine with care in patients on hemodialysis with porphyria, during pregnancy, Alzheimer's disease, with diabetes mellitus (pills for chewing).

Application during pregnancy

In the instructions for the drug it is said that during the launcher of the child, Maalox can be taken only in extreme cases. Sufficient studies that would confirm the safety of drug intake was not carried out, so the manufacturer recommends it only in cases where the health of women is more important than the risk of developing possible pathologies from the fetus.

When applying the drug in accordance with the dosing regimen, the absorption of combinations of aluminum hydroxide and magnesium salts in the mother's body is limited, so Maalox is recognized with breastfeeding compatible.

Before applying, be sure to consult your doctor.

Special indication

The patient should contact your doctor in case:

• loss of body weight;
• difficulty swallowing;
• disorders of digestion, which appeared for the first time, changes in the existing disorders of digestion;
• renal failure.

It is also important to take into account that with prolonged treatment by Maalox, the patient's diet should include a sufficient amount of phosphates, since one of the active substances of the drug (algelfrel) can reduce the level of phosphorus in the body.

Side effects for the body

• Constipation;
• Lack of appetite;
• Feeling of cutting and severity in the epigastric area;
• Nausea, vomiting.

Overdose

An overdose of suspension or Maalox tablets is manifested by the following symptoms:

• Diarrhea;
• Abdominal pain;
• Narrowing of intestinal lumen;
• Vomiting;
• Encephalopathy;
• Phosphorus deficiency.

Interaction with other drugs

The 2-hour interval should be observed between the use of the preparation of Maalox and other drugs.

Shelf life of tablets and suspensions

Store Maalox in a dark and dry place at room temperature. Bear from children in a closed place.

• The shelf life of the suspension in bags - 3 years, in bottles - 30 months.
• Shelf life after the first opening of the bottle is 6 months.

Analogs

Analogs of the drug Maalox are:

• Gastracide Tablets;
• Malukol;
• Alumag tablets;
• Almagel suspension;
• Gaviscon suspension and pills.

Prices in pharmacies

Cost various shapes Maalox in pharmacies fluctuates within the following limits:

• Maalox in tablets - about 230 rubles;
• Blue bags 4.3 ml, in packing 6 pcs. - 160 rubles;
• Suspension, 15 ml, package 30 pcs. - price of about 780 rubles;
• Suspension, 250 ml bottle - 450-500 rubles.

excipients: chloride hydrochloric acid 10%, citric acid monohydrate (EZZO), mint leaves oil oil, mannitol (E421), methylpaultol (E218), propyl aprichedroxybenzoate (E216), sodium saccharinate (E954), sorbitol 70% (E420), hydrogen peroxide purified water.

Description

Creamy liquid appearance Reminded milk, has a sweet taste and smell of mint.

Pharmacotherapeutic group

Antacid. The codeATX: A02AD01.

Pharmacodynamics

The drug neutralizes free hydrochloric acid, which leads to a decrease in the peptic activity of the gastric juice. Does not cause secondary hypersecretion. It also has an adsorbing and enveloping effect, reducing the effect of damaging factors on the mucous membrane.

It is passing for X-rays.

The total antacid capacity (titration at pH \u003d 1) is 44.9 mmol H + (iN. vitro. In the study of one dose by the Walter method).

Pharmacokinetics

Magnesium and aluminum hydroxides are considered local action antacids, practically not absorbed from the gastrointestinal tract when receiving in the recommended doses and, accordingly, do not provide common effects on the body.

Indications for use

Antacid therapy for heartburn and gastroesophaginal reflux in patients older than 15 years

Dosage and method of application

For use by patients over 15 years old!

Before applying the bottle, shake until a homogeneous suspension is obtained. Take 15 ml (1 tablespoon) suspension 4 times a day after 20-60 minutes after meals and before bedtime. The drug can be soaked with water or milk. Do not exceed the maximum daose dose of the medicinal preparation! The course of treatment is determined by the doctor.

Application of the drug in children Not recommended.

Contraindications

Increased sensitivity K. active substances either any other of the drug components. Porphyry. Heavy renal failure, as the drug contains magnesium. Childhood. Cachexia.

Special instructions and safety precautions

special instructions

2-hour interval should be observed between the use of Maalox and other drugs.

With caution should be prescribed to pregnant and nursing women.

The patient should contact your doctor in case:

Loss of body weight; difficulty in swallowing and persistent feelings of discomfort in the stomach; disorders of digestion, which appeared for the first time, changes in the existing disorders of digestion; renal failure.

Precautions

Aluminum hydroxide can cause constipation, an overdose of magnesium salts can lead to intestinal hypokinesia; The reception of high doses of the drug can cause or exacerbate the intestinal obstruction in patients with an increased risk of such complications, i.e. In patients with renal failure, in children under the age of 2 years, or in older people.

Aluminum hydroxide is poorly absorbed from the gastrointestinal tract, so the systematic action is rarely observed in patients with normal kidney function. However, the reception of high doses of the drug or long-term use, as well as the use of recommended doses with low phosphorus patients in a diet or children under 2 years old, can lead to phosphate deficiency (due to aluminum ability to bind phosphate ions), accompanied by increased bone resorption, hypercalcium and the risk of development of osteomalysis. In this regard, it is recommended to attend a doctor in case long use drug preparation, as well as in case of the risk of phosphate deficiency.

With low phosphorus content in the diet, aluminum hydroxide may cause phosphorus deficiency in the body.

In the case of patients with renal failure or in chronic dialysis, it is necessary to take into account the content of aluminum and magnesium in the preparation. With long-term use in high doses, including in high therapeutic doses, it is possible to develop encephalopathy, dementia, microcitar anemia, or a deterioration of osteomalysis caused by dialysis.

Aluminum hydroxide can be unsafe for patients with porphyria in hemodialysis.

If during the treatment of symptoms more than 10 days, as well as in the event of a deterioration in the course of the disease, should determine the cause of these symptoms and revise treatment.

In patients with renal failure, the joint use of the drug with citrates can lead to an increase in the level of aluminum in the plasma (see section Interaction with other drugs).

The drug contains parachidroxybenzoates (methyl and propyl parahydroxybenzoate), which can cause allergic reactions (perhaps a slow type).

Pregnancy I. breast-feeding

Pregnancy

Significant data on teratogenic action on animals is absent.

To date, there is no evidence of the development of congenital defects and fetotoxic effects in clinical practice. On the other hand, the possibility of observing pregnancies, during which the use of a drug was used is too limited in order to eliminate the likelihood of risk. Thus, for security reasons, the use of the drug during pregnancy is possible only if the potential benefits of its application justify the potential risk to the fetus.

The content of aluminum and magnesium ions can be taken into account that can influence the permeability of the gastrointestinal tract:

Magnesium hydroxide salts can cause diarrhea; Aluminum salts may cause constipation and worsen the flow of constipation often observed during pregnancy.

Long reception or taking the drug in high doses should be avoided.

Breast-feeding

During treatment, you can continue breastfeeding. Aluminum hydroxide in combination with magnesium salts is considered compatible with lactation.

Side effect

Side effectsobserved when applying the drug are classified into categories depending on the frequency of their occurrence: very often ≥ 10%, often ≥ 1 and

Subject to prescribed doses side effect The drug is insignificant.

Immunuted violations:

The frequency is unknown: the reaction of hypersensitivity, such as itching, urticaria, swelling of quinics and anaphylactic reactions.

Disorders from the gastrointestinal tract:

Infrequently: diarrhea, constipation, metabolic disorders and digestion.

The frequency is unknown: hypermagniasia, hyperaulummiamia, hypophosphatemia, with long-term use or when used in high doses of the drug, as well as when applying recommended doses with low phosphorus patients in a diet or children under 2 years old, the development of phosphate deficiency (due to the ability Aluminum bind phosphate ions), accompanied by increased bone resorption, hypercalcium and the risk of development of osteomalysis.

In the case of long-term use and in violation of the excretory function of the kidney, it is possible to increase the level of magnesium and / or aluminum in the blood plasma, the development of phosphorus deficiency in the body, encephalopathy.

In the elderly patients, there is an esgradation of bone-articular diseases, Alzheimer's disease.

Overdose

Magnesium overdose usually does not cause toxic reactions in patients with normal kidney function. Nevertheless, magnesium poisoning can develop in patients with renal failure (see section Precautions).

Symptoms of acute overdose combination of aluminum and magnesium hydroxide include diarrhea, abdominal pain, vomiting.

High doses of the drug may cause or exacerbate the intestinal obstruction in patients with an increased risk of this kind of complications.

The toxic effect depends on the concentration of magnesium in serum. Signs of toxic:

Decrease in blood pressure; nausea, vomiting; drowsiness, reducing reflexes, muscle fatigue, neuromuscular paralysis; Bradycardia, deviation of the ECG results; hypoventilation; In the most severe cases, palsy of breathing, coma, violation of the kidney or heart function can develop; Anuric syndrome.

Aluminum and magnesium are removed through the urinary tract. Magnesium overdose treatment: Rehydration, forced diuresis. In the case of renal failure, hemodialysis is needed or peritoneal dialysis.

Interaction with other medicines and other forms of interaction

Antacids interact with some other medicinal preparations For receiving inside.

Combinations requiring compliance with precautions

FROMquinidine

With simultaneous use with quinidine, it is possible to increase serum concentrations of quinidine and the development of overdose of quinidine.

In the case of simultaneous intake, Maalox can reduce the absorption of various drugs. Therefore, as a precautionary measure, the following drugs are recommended for 2 hours or 2 hours after receiving Maalox:

Acetylsalicylic acid, n2 -Anthigistamine, etcutol,isoniazid (oral), Atenolol,metoprolol, propranolol,cefidinir, cefpodoxin, chlorochin, cyclin, difluunisals, Digoxin,diphosphonates, fexophenadin, Iron Salts, Fluoroquinolones, Sodium Fluoride, Glucocorticosteroids (Prednisolone anddexametanone), indomethacin, ketoconazole,levothiroxin, lanzoprazole, lincoosamida, phenothiazine neuroleptics,penicilline, phosphorus (additives), thyroxine,rosavastatin, suljpirid.. With polystyrenesulfonate (kayeksalat)

Care should be taken while simultaneously use with polystyrenesulfonate (kayeksalatom) due to the potential risk of resin efficiency in potassium binding, the risk of metabolic alkalosis in patients with renal failure, as well as risk of intestinal obstruction.

With simultaneous reception with Maalox, the suction of the drugs listed above is reduced in the gastrointestinal tract. In the case of a 2-hour interval between the reception of these drugs and Maalox and the 4-hour interval between taking fluoroquinolones and Maalox in most cases of this undesirable interaction can be avoided.

In all cases, with simultaneous reception of Maalox with other drugs, it is necessary to inform the doctor about it.

Combinations that should be taken into account

- With salicylate: With simultaneous reception of salicylates and long-term use of the preparation, Maalox in high doses may increase the removal of salicylates with urine as a result of urine sickness.

With citrates

With a combination of aluminum hydroxide with citrates, it is possible to increase the plasma concentrations of aluminum, in particular, in patients with renal failure.

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