Sorbifer official instructions for use. Sorbifer Duruless, Shell Covered Tablets

Dosage form: & nbsptablets covered with film shell Structure:

Each tablet covered with film shell contains bivalent iron sulfate in an amount equivalent to 100 mg Fe 2+ and 60 mg of ascorbic acid, excipients: Magnesium Stearat, Pisidone K-25, Polyeten Powder, Carbomer 934P.

Shellcontains: Halgonellosu, macrogol 6000, titanium dioxide, iron oxide yellow, solid paraffin.

Description:

Round, double-screwed tablets, covered with light gray-yellow film sheath, with engraving "z" on one side, on a break of gray core with a characteristic odor.

Pharmacotherapeutic Group:Iron Preparation + Vitamin ATH: & NBSP

B.03.A.E.03. Iron preparations in combination with polyvitamins and minerals

Pharmacodynamics:

The iron is bivalent (Fe (II)) as a component of the protoporphyrine prosthetic group of hemoglobin (HB) plays an important role in the binding and transport of oxygen and carbon dioxide.

Iron protoporphyrin group of cytochromes plays a key role in the electron transport process. In these processes, the capture and returns of electrons are possible due to the reversible reaction of the transition Fe (II) ↔Fe (III).

Iron in significant quantities are also in the Mioglobin of the muscles.

Ascorbic acid contributes to the suction and absorption of iron (it stabilizes the FE ion (and), preventing it in the transformation into the FE (III) ion.

Mechanism of action

Long-term release of FE ions (II) is the result of the technology of creating durul tablets. During passing through the gastrointestinal tract (gastrointestinal tract), Fe (II) ions are constantly released from the porous matrix of Duruless tablets for 6 hours. Slow release active substance Prevents the development of pathologically high local iron concentrations. Thus, the use of the drug sorbifer Durouples avoids damage to the mucous membrane.

The iron is an indispensable component of the organism necessary for the formation of HB and the flow of oxidative processes in alive tissues. The drug is used to eliminate iron deficiency.

Plastic matrix tablets sorbifer Doruples is completely inert in digestive juice, but completely disintegrating under the action of intestinal peristaltic, when the active ingredient is completely released.

Pharmacokinetics:

Iron is absorbed from duodenal gut and proximal department fine intestine. The degree of suction of iron associated with the gem is approximately 20%, and iron not related to gem is 10%. For efficient absorption of iron should be in the form of FE II).

After the intake, inside is completely absorbed from the gastrointestinal tract. The hydrochloric acid of the stomach stimulates the absorption of iron, restoring it from Fe (III) to Fe (II). Improves iron absorption and increases the bioavailability of the drug (LS).

FE (II) incoming to epithelial cells is subjected to intracellular oxidation to Fe (III), which is associated with Apotheferritin. Part of the apoferritin enters blood, the other part temporarily remains in the intestinal epithelial cells in the form of ferritin. which will go into blood after 1-2 days or bring out of the body with the feces in the process of desquamation of epithelial cells.

About 1/3 of the iron entering the blood binds to Apotransferrin, the molecule of which is turning into transferin. The iron and transferin complex is transported to the target organs and after binding to receptors located on the surface of their cells, it enters the cytoplasm with the help of endocytosis. In the cytoplasm of iron is separated and responded with apotheferritin. Apotheferritin oxidizes iron to Fe (III), and flavoproteins are involved in the repair of iron.

"Durules" is a technology that provides a gradual release of the active substance (iron ions), uniform receipt of the drug. The reception of 100 mg twice a day provides for 30% greater absorption of iron from the drug sorbifer Durules compared to other iron preparations.

Deposited in the form of ferritin or hemosiderin in hepatocytes and cells of the phagocytic macrophage system, a slight amount - in the form of myoglobin in the muscles.

The half-life (T 1/2) is 6 h.

There are no data on pharmacokinetics of the drug in disruption of the liver or kidney function, as well as in elderly patients.

Indications:

Conductible anemia, prevention and treatment.

States accompanied by iron deficiency.

Prevention of iron deficiency during pregnancy, lactation and blood donors.

Contraindications:

Increased sensitivity to active substance or any of the auxiliary substances;

Pathological processes accompanied by increased iron deposits (for example, hemochromatosis, hemosiderosis);

Regular blood transfusions;

Other types of anemia that are not associated with iron deficiency (aplastic, hemolytic anemia, thalassemia, megaloblastic anemia) or caused by impaired iron disposal (Sideroichreniy anemia, anemia caused by lead poisoning);

Stenosis of the esophagus, intestinal obstruction and / or obstructive gastrointestinal changes, sharp bleeding of the gastrointestinal tract;

Sharing S. parenteral drugs gland;

Conditions associated with ascorbic acid: hyperoxalura, oxalate kidney stones;

Thrombophlebitis, tendency to thrombosis;

Childhood up to 12 years (due to lack of clinical data).

Carefully:

Peptic ulcer and duodenal ulcer, inflammatory diseases Intestine (enteritis, diverticulitis, ulcerative colitis, Crohn's disease).

Elderly age Patient (due to the lack of adequate clinical data).

Liver diseases, kidneys (due to the absence of adequate clinical data), acute infectious inflammatory processes (see section "Outdoor instructions").

Pregnancy and lactation:

Sorbifer Duruless can be used during pregnancy and in breastfeeding period.

Method of use and dose:

Dosing mode

Treatment

Adults and adolescents over 12 years old:

Patients S. iron deficiency anemia If necessary, the dose can be increased to 3-4 tablets per day for two receptions (in the morning and evening).

Maximum dose - 4 tablets per day.

Prevention and treatment during pregnancy

The duration of use is determined individually, on the basis of laboratory indicators characterizing the state of the exchanging of iron.

Treatment should be continued until the optimal concentration of hemoglobin and the restoration of laboratory metabolism of iron exchange in the blood plasma is reached. To further replenish the depot, you may need to continue receiving the drug for another two months. Typically, the duration of treatment with a significant loss of iron is 3-6 months.

It is necessary to take into account the official local guidelines for the appropriate use of iron-containing LS for the treatment and prevention of anemia related to iron deficiency.

Special groups of patients

Patients with impaired liver and kidney function

Due to the lack of adequate clinical data, the drugs should be taken with caution.

Elderly patients

Due to the lack of adequate clinical data in elderly patients, drugs should be taken with caution.

Children and adolescents under the age of 18

Tablets can not be prescribed to babies and children under 12 years old.

Mode of application

Tablets for reception inside.

The tablet cannot be divided, chew, keep in the mouth or dissipate. The tablet should be swallowed entirely and put water. Tablets can be taken before eating or during food, depending on the individual tolerance of the gastrointestinal tract.

It is impossible to take tablets in the lying position.

Side effects:

During treatment with the drug, the sorbifer Duruless received reports on the following side effects, which are given below by organ systems.

Blood violations and lymphatic system : Paroxysmal night hemoglobinuria, erythropoietic porphyria or late skin porphyry.

Violations from immune system : Hypersensitivity, urticaria,anaphylaxis.

Violations from nervous system: headache, dizziness, weakness, irritability.

Disorders of the respiratory system, organs chest and mediastinum: Highland swelling, sore throat.

Random to enter iron-containing drugs in airways It may lead to irreversible bronchial necrosis (especially in elderly patients and patients experiencing difficulties in swallowing).

Gastroy violations: nausea, abdominal pain, diarrhea, diarrhea, stool changes, dyspepsia, vomiting, gastritis, ulcerative damage to esophagus, stenosis of the esophagus, meteorism, dyeing (with improper use of tablets), ulcers in the oral cavity.

Disturbing from the skin and subcutaneous fabrics: Skin rash, itching.

Disorders from the kidneys and urinary tract: when applied in high doses - hyperoxaluria and the formation of oxalate renal stones.

General disorders and disorders at the place of administration: the feeling of heat. Postregister period

In the final period received reports on the following adverse reactionswhose frequency is unknown.

Gastroy violations: Development of ulcers in the mouth *.

* Observed with improper use when the tablets are chewed, they are dissolved or kept in the mouth. Elderly patients and patients with violation of swallowing have the risk of damage to the esophagus and bronchial necrosis with random hit in the respiratory tract.

Message about adverse reactions

The provision of data on the alleged adverse reactions of the drug is a very important point that allows for continuous monitoring of the Risk / Purity Risk / Use ratio. Medical workers should provide information on any intended adverse reactions at the contacts specified at the end of the Instruction, as well as through the National Information Collection System.

Overdose:

The relatively low dose of iron can cause symptoms of intoxication. The dose of iron equivalent to 20 mg / kg can already cause some symptoms of intoxication, and the content of iron exceeding 60 mg / kg, the development of intoxication is expected. The iron content equivalent to 200-250 mg / kg may result in death.

Symptoms

The determination of serum iron concentration can help in assessing the severity of poisoning.

Although the iron concentration does not always correlate well with symptoms, its concentration, determined 4 hours after swallowing, indicates the severity of poisoning:

• less than 3 μg / ml - light poisoning;
• 3-5 μg / ml - moderate poisoning;
• \u003e 5 μg / ml - severe poisoning.

The maximum concentration of iron is determined 4-6 hours after the iron ingress.

Weak and moderate poisoning:vomiting and diarrhea can develop within 6 hours after swallowing.

Heavy poisoning:heavy vomiting and diarrhea, lethargy, metabolic acidosis, shock, bleeding from the gastrointestinal tract, coma, cramps, hepatotoxicity, later - stenosis of the gastrointestinal stenosis. Heavy toxicity also causes necrosis of the liver and jaundice, hypoglycemia, blood clotting disorders, oliguria, renal failure and pulmonary swelling.

Overdose of iron salts is especially dangerous in children in early age.

Overdose ascorbic acid may cause heavy acidosis and hemolytic anemia in predisposed persons (deficiency of glucose-6-phosphate dehydrogenase).

Treatment :

1. Milk and liquid causing vomiting (as soon as possible).

2. The production of the stomach is a 5% sodium solution of bicarbonate and salt laxatives (for example, sodium sulfate, in a dose of 30 g for adults); Milk and eggs in combination with 5 g of bismuth carbonate as softening means.

After washing the stomach, 5 g of deferoxamine was introduced, dissolved in 50-100 ml of water, and this solution is left in the stomach. To stimulate the activity of the intestine, adult patients can give a solution of mannitol or sorbitol inside. Customization of diarrhea in children, especially at an early age, can be dangerous, so it is not recommended.

Patients should be carefully monitored in order to prevent aspiration.

3. The piltiograph of the tablet give the shadow, so using a radiograph abdominal cavity You can reveal the tablets remaining after caused by vomiting.

4. Dimmercaprol should be used, as it forms toxic complexes with iron.

Deferoxamine is a specific preparation that form a chelate complex with iron. In acute serious poisoning, children should always be prescribed in a dose of 90 mg / kg intramuscularly, then 15 mg / kg intravenously, while the concentration of iron in the blood serum will not correspond to the overall iron binding ability of the serum. With too fast infusion speeds, hypotension can develop.

5. In less severe intoxication is prescribed intramuscularly at a dose of 50 mg / kg to maximum dose in 4 g.

6. In severe intoxication: in a state of shock and / or coma and in case of increasing concentration whey gland (\u003e 90 mmol / l in children,\u003e 142 mmol / l in adults), it is necessary to immediately begin intensive supporting therapy. Blood transfusion or plasma is carried out at shock, the purpose of oxygen therapy is due to respiratory failure.

Interaction:

Sorbifer Durules do not combine with the following drugs:

-ciprofloxacin: when used together, the absorption of ciprofloxacin decreases by 50%, thus there is a danger that its plasma concentration does not reach therapeutic level;

-levofloxacin: When used together, the suction of Levofloxacin decreases;

-moxifloxacin: With co-use, the bioavailability of moxifloxacin decreases by 40%. With the simultaneous use of Moxifloxacin and the drug, the sorbitol Dorules between the reception of these drugs should withstand the maximum possible time interval, which is at least 6 hours;

-norfloxacin: When combined, the absorption of norfloxacin decreases by about 75%;

- offloxacin : When used together, the suction of offloxacin decreases by about 30%;

- mikophenolate Mofetil: A sharp decrease in the absorption by 90% of mikophenolate of mofetil was observed when co-use with glax preparations.

With the joint use of the sorbifer of Duruless with the following drugs may occur The need to change their dose. Between the reception of the drug sorbifer Dorules and any of these drugs should withstand the maximum possible time interval, which is at least 2 hours:

- Food additives containing calcium or magnesium as well antacid drugscontaining aluminum, calcium or magnesium:they form complexes with iron salts, thus worsening, so sucking each other;

-Captor: while simultaneously use with a captive, its area under the concentration-time curve (AUC) decreases by an average of 37%, probably due to a chemical reaction to the gastrointestinal tract;

- Zinc : while using the absorption of zinc salts decreases;

-Klodrontat: In research in vitro.it was found that the preparations containing iron form a complex with a clodronate. Despite the fact that research in vivo. were not conducted, it can be assumed that when co-use, the absorption of the clodronate decreases;

- Deferoxamine : When combined, the absorption of both deferoxamine and iron decreases due to the formation of complexes;

- Legodopa and carbidop: With the joint use of iron sulfate with levodopa and carbide - probably due to the formation of complexes - levodop biosavaability in healthy volunteers decreases by 50%. and carbide - by 75%;

-Methyldopa (levovrat): with the joint use of iron salts (sulfate and iron gluconate) with methyldop - probably due to the formation of chelate complexes - methyldop biosavaability decreases, which may worsen its antihypertensive effect;

- Penicilline : With the joint use of penicillamine with iron salts - probably due to the formation of chelate complexes - suction like penicillamine. So iron salts decrease;

- Alendronat. : In the study iN.vitro. preparations containing iron formed complexes with alendronate, lowering the suction of the latter. Results in conditions in vivo. missing;

-Risedronat: In vitro studies, iron containing iron formed complexes with risader. Despite the fact that such interaction has not been studied in conditions in vivo., it can be assumed that when co-use, the absorption of the risadron will decrease;

- Tetracycline : When used together, tetracycline absorption decreases, so combined application You should withstand the maximum possible time interval, which is at least 3 hours between the receptions. The use of iron-containing drugs worsens the ENTEROGAPATA cycle of doxycycline, both when taking inside and intravenous administrationtherefore, you should avoid sharing these funds;

- Hormones thyroid gland : With the joint use of iron-containing preparations and thyroxine, the suction of the latter may decrease, which can lead to the unsuccessfulness of substitution therapy;

-Cimetidine: With the joint use of the sorbifer of durul with cimetidine, a decrease in the acidity of the stomach caused by cimetidine, reduces the absorption of iron.

Other interactions:

- FROM treatments of iron And other drugs, which include iron: It is possible to accumulate iron in the liver; the likelihood of iron overdose increases;

- FROM pancreatine, skewers: There is a decrease in the absorption of iron from the gastrointestinal tract;

- FROM methyldioxiphenylalanine: reducing the absorption of methyldioxyphenylalanine in oral cavity at 61-73%;

- FROMtocopherol: The activity of both drugs is reduced;

- FROM glucocorticosteroids: It is possible to increase the stimulation of erythropois;

- With Allopurinol: It is possible to accumulate iron in the liver;

- FROM acetohydroxamic acid: The activity of both drugs is reduced;

- FROM chloramphenicol: The effectiveness of iron preparations is reduced. The formation of erythrocytes is suppressed and the HB concentration is reduced;

- With ethanol: The absorption and risk of toxic complications increases;

-FROMethydron acid: The activity of ethydron acid is reduced. It should be taken no earlier than 2 hours after taking the drug sorbifer Durouples.

Interactions associated with ascorbic acid

Increases the concentration of salicylates in the blood (increases the risk of crystalluria's development), ethinyl estradiol, gasolinepenicillin and tetracycline.

Lowering concentration perverse contraceptives. Acetylsalicylic acid and oral contraceptivesalso reduce the absorption and absorption of ascorbic acid.

Increases the activity of norepinephrine.

Reduces anticoagulant effect cumarine derivatives, heparin.

It improves suction in the intestines of iron preparations, as well as iron from food (due to the transfer of Fe (III) ↔Fe (II)).

Enhances overall clearance ethyl alcohol. It may affect the effectiveness of disulfirama in the treatment of chronic alcoholism.

The simultaneous use of ascorbic acid and deferoxamine increases the excretion of iron.

Interaction with food products and drinks

When using the drug sorbifer doruluce with tea, coffee, eggs, dairy products, bread from coarse grinding, cereals from grains or food rich in fibers, iron absorption can decrease.

Fresh juices and alkaline drinks reduce the suction and absorption of ascorbic acid. The time interval between the reception of the drug and the use of these products should be at least 2 hours.

Special instructions:

The drug is effective only with diseases accompanied by iron deficiency. Before starting treatment, the iron deficiency should be diagnosed. With other, non-iron deficient types of anemia (anemia due to infection, anemia accompanying chronic diseases, Thalassemias and other anemia) Purpose of the drug is contraindicated (see "Contraindications" section).

Due to the risk of developing ulcers in the oral cavity, as well as to prevent coloring of dental enamel, the tablet can not be chewed, keep the tablet in the mouth or dissolve the tablet should be swallowed and put it with water.

Reception of iron preparations can cause staining of the chair in black.

During treatment with oral iron preparations, an aggravation of inflammatory or peptic gastrointestinal diseases may occur.

Do not use the drug in infectious and inflammatory processes (acute respiratory viral infection, angina, pneumonia, etc.), since in this case the iron is accumulated in the focus of inflammation and is not effective for its intended purpose.

According to studies iN.vitro. iron preparations increase the pathogenicity of some microorganisms and can negatively influence the forecast of the flow of infectious diseases.

Hyposteria, associated with inflammatory syndromes, is not sensitive to therapy with iron preparations.

When taking the drug is possible false positive result Kata Analysis on Hidden Blood.

Ascorbic acid in the urine can lead to distortion of results when determining sugar in the urine.

To improve the absorption of iron from the intestine, simultaneously with treatment should be fully eaten by using meat products, vegetables, fruits.

The drug should not be powered by strong tea, coffee, milk. Consumption of significant amounts of tea suppresses the absorption of iron.

Alcohol should not be used during treatment.

It should not be discontinued immediately after the normalization of the hemoglobin concentration and the number of erythrocytes. In order to create an iron in the body, iron needs to take a drug at least 1-2 months.

Random hitting of iron-containing drugs in the respiratory tract can lead to irreversible bronchial necrosis. Therefore, in the case of accidental inhalation of pills fragments, it is necessary to immediately apply for medical attention.

To avoid risk possible overdose gland, special caution It is required to observe if other gland additives are used.

Impact on the ability to control the transc. cf. And Meh.:

Sorbifer Durules does not affect the ability of the car and control mechanisms. There are no such data.

Release form / Dosage:

Tablets covered with film shell.

Packaging:

30 or 50 tablets in the brown glass bottle with PE with a cover with the control of the first autopsy and the harmonic-shock absorber.

1 bottle along with instructions for medical application Invest in a cardboard pack.

Storage conditions:

At temperatures from 15-25 ° C.

Keep out of the reach of children.

Shelf life:

Do not use after the expiration of the expiration date specified on the package.

Conditions of vacation from pharmacies:On prescription Registration number:N011414 / 01 Registration date:07.05.2010 / 21.01.2019 Execution Date:Durable Registration Certificate Owner:Egis Pharmaceutical Plant OJSC Hungary Manufacturer: & NBSP Representation: & NBSPEgis CJSC Pharmaceutical factory Hungary Date of updating information: & NBSP25.09.2019 Illustrated instructions

Instructions for use:

Sorbifer international name - Iron sulfate + ascorbic acid) refers to the group of anti-diamemine drugs that replenish the lack of iron. The drug has high efficiency and safety, due to which is prescribed during pregnancy and breastfeeding.

The widespread use of sorbifer received as an effective stimulator to reduce the content of iron in the body after severe diseases, operations and long bleeding.

Composition and form of release

Maintenance active substances - Ascorbic acid 60 mg and iron sulfate 100 mg.

Auxiliary components: magnesium stearate, powder polyethylene, carbomer, poverant.

Sorbifer is produced in 160 mg tablets in a cardboard package of 30-50 pcs. Each tablet is covered with a shell consisting of paraffin, iron oxide, titanium dioxide, hypimosellose and macrogol.

Pharmacological properties of sorbiper

Sorbifer is a combined drug efficient to restore iron levels in different types of anemia. Due to the combination of iron sulfate and ascorbic acid, antianemic effect is achieved.

Good reviews Sorbifer has as a preparation of high absorption with a gradual release of iron ions, which avoids an excess of iron in the gastrointestinal tract and blood.

Iron sulfate and vitamin C contribute to the production of hemoglobin and oxygen transportation. Ascorbic acid acts as antioxidant and collagen, providing tissue regeneration.

According to the description, sorbifer is effective in impairment of iron absorption and its chronic deficiency in the body.

Indications for the use of sorbifer

The sorbifer is appointed with iron deficiency anemia of various etiologies, including during pregnancy and lactation, in the postoperative period, after suffering severe diseases and bleeding, chronic diarrhea.

Positive feedback Sorbifer received as an effective prophylactic drug with diet, unbalanced nutrition and low iron absorption.

Instructions for use

In accordance with the instruction, sorbitol must be taken inside 2-3 times a day for 2 tablets after meals, drinking with plenty of water. The daily dose of the drug is 100 - 200 mg, depending on the diagnostic testimony of the patient.

With iron deficiency anemia, the drug should be taken 2 tablets 2 times a day, and for preventing iron deficiency - 1 time per day at 100 mg.

According to the instructions, the sorbitol should not be taken to children under 12.

Application during pregnancy

When diagnosing, sorbifer is prescribed in a pregnant woman. The drug can be taken both for treatment and for the prevention of anemia during the second and third trimester of pregnancy. Also sorbifer can be appointed with multiple pregnancy with bleeding.

Sorbifer during pregnancy should be taken after eating 2 times a day on one tablet. The daily dose should not exceed 200 mg. The dosage is determined in accordance with the analyzes of the patient. With the correct dosage of hemoglobin rises within 2-3 weeks after the start of reception.

During the reception period, a pregnant patient should not use products and preparations with increased content Calcium. There should be 2-3 hours between taking sorbifer and antacid drugs.

Sorbifer is contraindicated pregnant patients with stenosis of the esophagus, metabolic disorders, severe gastrointestinal diseases and excessive iron content.

Contraindications

Contraindications for the purpose of sorbitol are hypersensitivity and intolerance to the components of the drug, an increased iron content, bleeding and severe gastrointestinal diseases, renal and liver failure, peptic ulcer.

With caution, the drug is prescribed to patients after blood transfusion, with colitis and crown disease.

Side effects of sorbitator and reviews

According to the description and response, sorbitol does not cause serious side effects.

In rare cases, when taking the drug may appear allergic reactions And disorder functioning of the gastrointestinal tract - nausea, vomiting, constipation, urticaria, dermatitis, bronchospasm, diarrhea.

Pills covered with shell - 1 tab. Iron sulfate - 320 mg (which corresponds to 100 mg of iron II) acid ascorbic acid - 60 mg excipients: magnesium stearate; Povidone K-25; polyherta powder; Carbomer 934r Shell: HalpRellos; macrogol 6000; titanium dioxide; Iron oxide yellow; Paraffin solid in dark glass bottles of 30 or 50 pcs.; In a pack of cardboard 1 bottle.

Description of the dosage form

Round two-yellow double-yellow tablets, with "Z" engraving on one side, on a gray-colored core, with a characteristic odor.

Pharmacokinetics

Duruless® is a technology that provides a gradual release of the active substance (bivalent iron ions) from tablets, uniform receipt of the drug in blood. The reception of 100 mg 2 times a day provides 30% greater absorption of iron from the drug sorbifer® Durules® compared to conventional iron preparations. Absorption and bioavailability of iron are high. Iron is absorbed mainly in the duodenum and proximal part tochyan. Binding with plasma proteins is 90% or more. Deposited in the form of ferritin or hemosiderin in hepatocytes and cells of the phagocytic macrophage system, a slight amount - in the form of myoglobin in the muscles. T1 / 2 is 6 hours.

Pharmacodynamics

Iron - an indispensable component of the body necessary for the formation of hemoglobin and the flow of oxidative processes in the tissues. Durules® technology provides a phased release of the active ingredient (iron ions) for a long time. Plastic matrix tablets sorbifer® Dorulu® inert in digestive juice, but completely disintegrates under the action of intestinal peristaltics, when the active ingredient is completely released.

Indications for use Sorbifer Duruless

• treatment and prevention of iron deficiency anemia.

Contraindications for use sorbifer durul

Diseases accompanied by the accumulation of iron in the body: aplastic and hemolytic anemia, anemia, hemochromatosis.

Sorbifer Dorules Application during pregnancy and children

No contraindications.

Sorbifer Duruless Side Action

• lack of appetite, nausea, vomiting, diarrhea;
• skin rash, itching.

Medicinal interaction

It may reduce the absorption of simultaneously used ECCSACIN, CLODRONATA, GREADFLAXACOLINA, Levofloxacin, Levodopa, Methyldopes, Penicilline, Tetracycline and Thyroid Hormones. The simultaneous use of the drug sorbifer® durul® and antacids containing aluminum hydroxide and magnesium carbonate can reduce the absorption of iron (the interval between their reception should be at least 2 hours), in the case of tetracyclines, the minimum interval must be 3 hours. Sorbifer® Durules® is not It should be combined with ciprofloxacin, doxycycline, norfloxacin and offloxacin.

Dosage sorbifer Durules

Adults are prescribed for 2 stages 3 times in day; Children - 1-2 Dragee 3 times in day, newborn - 1 dragey 3 times in day.

Overdose

Symptoms: abdominal pain, vomiting, fatigue or weakness, hyperthermia, paresthesia, pallor skin, heartbeat. Treatment: washing the stomach, inside - a raw egg, milk (for binding iron ions in the gastrointestinal tract), the introduction of deferoxamine, symptomatic therapy.

Anemia is one of the most common diseases of the hematopoietic system. This pathology is characterized by a decrease in the amount of red oxygen blood cells (Erythrocytes). Another anemia is often accompanied by a decrease in hemoglobin levels.

For treating anemia, combined drugs are used, in which there is iron and ascorbic acid. One of best medicines This group is considered sorbifer durul.

Its release form - tablets for oral application. The production of medicine is engaged in the Hungarian company EGIS. You can purchase one package (50 tablets) in 200-350 rubles. Also in pharmacies there is a package of 30 tablets, it costs somewhat cheaper - in the area of \u200b\u200b150-200 rubles. Vacation sorbier Durouples is carried out without a recipe.

Composition and pharmacological action Sorbifer Duruless

Malokrovia (anemia) is a condition that is often observed in children, pregnant women and lactating women, donors and people who recently suffered massive blood loss. Anemia is dangerous for life, because other dangerous pathologies can develop on her background.

For Malokrovia characteristic oxygen starvation. In view of this, the person complains about strong weakness, constant headaches, dizziness, lack of appetite. Also changing color skin cover and can jump blood pressure. Bradycardia is not excluded - a condition in which the frequency of heart rate is less than 50 shots per minute.

Sorbifer Duruless is one of the best combined tools for the treatment of anemia of any genesis. The preparation includes two active components at once, namely iron sulfate and ascorbic acid. In addition, the tablets contain excipients that do not possess pharmacological activity.

Therapeutic effect:

1. Iron sulfate is a component that is necessary for the formation of erythrocytes and the formation of hemoglobin. If the substance is inserted into the body increases the level of iron in the blood, saturates blood oxygen, stops characteristic symptoms Oxygen starvation. Iron sulfate successfully fights drowsiness, dizziness, headaches. Also, according to doctors, this substance stabilizes the work of cardio-vascular system. Iron sulfate strengthens the vascular walls, reduces their permeability, contributes to stabilization arterial pressure And pulse, warns hypertensive and hypotonic crises, bradycardia, tachycardia. Still substance normalizes cellular respiration, contributes to the disposal of a certain kind of toxins, and even contributes to the stabilization of the number exchange processes. Thus, iron sulfate is extremely necessary for normal cholesterol flow.
2. Ascorbic acid. This component is also extremely necessary at anemic states. The fact is that ascorbic acid, first, strengthens therapeutic action Iron sulfate. In addition, the component is necessary for a number of essential redox processes. Vitamin C stabilizes the transformation process folic acid In folates, normalizes the functionality of the brain, strengthens the immunity, increases the level of hemoglobin in the blood, increases the absorption of non-hymmatic iron from vegetables and fruits.

In the review it is worth mentioning a number of the most important facts About the drug sorbifer Dorules. No wonder in his title there is the end of the "Duruless". It means that in the production of the drug, a certain technologist is used, with which the gradual release of iron ions is ensured. That is, the active component of the drug is distributed evenly and faster, compared with other iron-containing medicines.

Absorption and bioavailability of iron sulfate are very high. Iron is absorbed mainly in the duodenum and the proximal part of the turntable. The binding of active components with plasma proteins is also very high - in the region of 90%.

The preparation half-life is 6 hours. Deposit sorbifer durul in the form of hemosidere and ferritin in hepatocytes (liver cells).

• Speed
• Stunning effect, due to two active ingredients
• Good tolerability
• Low cost
• Ability to use during pregnancy and lactation
• The drug provides uniform absorption of iron

• Badly combined with antacids
• Contraindicated children
• It is impossible to combine with certain antibiotics

Instructions for use of the drug

Indications for use

The drug sorbifer Duruless has a lot of indications for use. The main is the iron deficiency anemia - a condition that is characterized by a violation of hemoglobin synthesis due to iron deficiency.

Sorbifer Durouples allows for the shortest possible time to increase the level of iron in the blood, stabilize the level of hemoglobin and erythrocytes. The use of a drug in preventive purposes to people prone to iron deficiency anemia is allowed.

In addition, the testimony for use serve:

• Prevention of iron deficiency anemia in blood donors.
• Prevention of Malokrovia during pregnancy and lactation.
• Acute iron deficiency in the blood.
• States that require raising hemoglobin levels. This includes some cardiovascular pathologies, including hypotension, bradycardia, hypertension.

Method of use

Consider in more detail how to take sorrifer Dorules. The annotation says that the tool must be taken inside. Tablets can not be chewed and dissolved. Put the drug with plenty of water.

The dosing mode will depend on the specific disease and the degree of its running. Pregnant and lactating women for preventing iron deficiency anemia are enough to take 1 tablet 1-2 times a day for several weeks. Sometimes several preventive courses are held throughout the pregnancy.

Blood donors and people who have a tendency to iron deficiency, patients with cardiovascular diseases are also quite enough to take 1 tablet 1-2 times a day for 2-5 weeks. Preventive courses can be carried out up to 3-5 times a year.

With iron deficiency anemia, the dosing regime undergoes changes. Patients are recommended to drink 1-2 tablets 2 times a day. The course of treatment is sometimes for up to 3-4 months, in advanced cases - until six months. Throughout therapy, it is necessary to control the level of hemoglobin and erythrocytes in the blood.

Contraindications of drug

Sorbifer Durouples has a number of contraindications to use. First, the tool is not used in pediatric practice. The official instruction mentions that drugs are contraindicated to children under 12 years old.

It is also strictly forbidden to use the agent to people who have noted increased sensitivity To iron sulfate, ascorbic acid or the auxiliary components of the medication.

Back to the list of contraindications includes:

1. States that are accompanied by an increased iron content in the body. This includes hemosiderosis and hemochromatosis.
2. Violation of iron disposal. This pathology is characteristic of lead anemia, sederascular anemia, hemolytic anemia.
3. Acute violations in the work of the organs of the gastrointestinal tract. These include obstructive changes digestive tract, stenosis of the esophagus, ulcerative ulcer of the stomach and 12-rosewood in the aggravation stage, acute gastritis with increased stomach acidity.

With caution, the sorbifer Duruless is prescribed to persons who have in history inflammatory diseases of the intestines, including enteritis, diverticulitis, ulcerative colitis, Crohn's disease.

These contraindications are due to the fact that the suction of the active components of the LS occurs in the intestine, and with inflammatory processes in it, iron sulfate can harm health.

Side effects

Sorbifer Durules is usually transferred to patients well, especially if you comply with all the treatment recommendations, in particular, comply with the diet, avoid stress and emotional overloads.

As a rule, skills are developing in people who either have a unhealthy lifestyle during therapy, or exceeded the recommended dose, or were taken by LS for too long (more than six months).

Annotations mention the following side effects:

• Violations of organs digestive system. When using tablets, some patients appeared nausea, vomiting, pain in the abdominal area, diarrhea, constipation. It has been reported on single cases of occurrence. inflammatory processes In the intestines. A case is also known when the ulcerative ulcer of the stomach and the 12-rosisome integrated in the use of elevated dosages.
• Stenosis of the esophagus.
• Allergic reactions. Possible swelling of quinque, itching, redness of the skin, peripheral edema, rash, urticaria.
• Violations by the Cardiovascular Bodies. It is reported that the drug may cause an increase in blood pressure, to participate the frequency of heart abbreviations, and even contribute to the development of myocardial dystrophy.
• Failures in the work of the CNS and the peripheral nervous system. They manifest themselves in the form of migraine, dizziness, weakness, drowsiness.

Overdose of medicines leads to more severe consequences. The instructions say that in overdose possible acute pain In the abdomen, vomiting with blood, weakness, sharp drop in blood pressure, bradycardia. With pressure, we recommend learn more about. Overdose shows symptomatic therapy. Medicas are recommended before the "ambulance" arrival to rinse the stomach, drink milk or eat a raw egg, as these products bind iron ions in the gastrointestinal tract.

Medicinal interaction and special instructions

It is very important to take into account that Sorbifer Duruless joins interacting with others. drugs. Annotations mention that LS reduces the absorption of enocusacin, clodronate, levodopa, levofloxacin, goldenfloxacin, methyldopes, penicillamine, tetracycline and thyroid hormones.

The simultaneous use of sorbifer with antacids, in which there are aluminum hydroxide and magnesium carbonate, can lead to a decrease in iron absorption in the stomach. The manufacturer recommends that the sorbifer and antacids are withstanding the interval in 2-3 hours. However, this does not concern cases when HP is combined with tetracycles. Then the interval rises to 3-4 hours. It is categorically not recommended to combine the drug with ciprofloxacin, doxycycline, norfloxacin, offloxacin.

Special instructions:

1. During the taking soribert, you need to monitor the level of hemoglobin and blood erythrocytes.
2. Long-term use of pills can lead to the fact that the feces will darken. This is considered the normal reaction of the body.
3. During treatment, it is strongly recommended to comply with the diet and refrain from reception. alcoholic beverages. The alcohol can significantly reduce the efficiency of the sorbifer and increase the likelihood of side effects on the part of the organs of the gastrointestinal tract.

In this medical article you can get acquainted with medicinal preparation Soribifer. Instructions for use will explain, in what cases can be taken tablets, from which the medicine helps, what are the indications for use, contraindications and side effects. Annotations presents the form of the drug and its composition.

In the article, doctors and consumers can only leave real Reviews About soribher, from which it is possible to know whether the medication helps in therapy of iron deficiency in the body, anemia and increase the level of hemoglobin in adults and children, for which it is prescribed. The instructions lists the analogues of the sorbifer, the price of the drug in pharmacies, as well as its use during pregnancy.

The drug belonging to the group of anti-diamemic drugs is sorbifer Durouples. Instructions for use prescribes taking tablets to replenish the lack of iron in the body.

Release form and composition

Sorbifer is released in 160 mg tablets in a cardboard package of 30-50 pcs. Each tablet is covered with a shell consisting of paraffin, iron oxide, titanium dioxide, hypimosellose and macrogol. The main active substances are ascorbic acid 60 mg and iron sulfate 100 mg.

The drug sorbifer Duruless is produced in dosage form Tablets for reception inside. They have a round shape, a biconide surface, yellow. The preparation includes several main operating components, their content in one tablet is:

• Iron sulfate - 300 mg.
• Vitamin C (ascorbic acid) - 60 mg.

Tablets sorbifer Durouples are packaged in a dark glass bottle in the amount of 30 and 50 pieces. Cardboard pack contains one bottle with tablets and instructions for the use of the drug.

pharmachologic effect

The sorbifer Durouples is a combination tool that is used to normalize the level of iron with different types of anemia. Due to the action of the active components of the drug, iron sulfate and ascorbic acid, this agent has an anti-diamemine property.

The drug is characterized by high suction with the gradual release of iron ions, which avoids the reduction of iron in the blood and the gastrointestinal tract. Vitamin C and iron sulfate ensure the transportation of oxygen and the production of hemoglobin.

Ascorbic acid acts as antioxidant and collagen, which promotes tissue regeneration. The sorbifer of Durules is used if the patient has disorders of iron absorption, as well as with its chronic deficiency in the body.

Indications for use

What does sorbifer help? Tablets are prescribed:

• under anemia (due to lack of iron);
• with a deficiency of iron in the body;
• as a preventive tool in pregnant and nursing women and blood donors.

Instructions for use

Sorbifer is taken inside. Sheath-covered tablets cannot be divided or chewed. The tablet should be swallowed and put it off at least half a glass of liquid. Adults and adolescents are prescribed 1 tablet 1-2 times a day.

If necessary, patients with iron deficiency anemia, a dose can be increased to 3-4 tablets per day in 2 receptions (in the morning and evening) for 3-4 months (before replenishing the iron depot in the body). During pregnancy and during the lactation period with the purpose of prevention, 1 tablet per day is prescribed; For treatment, 1 tablet is prescribed 2 times a day (in the morning and evening).

Read also this article: Bacytatin: 500 mg tablets

Treatment should be continued until the optimal level of hemoglobin is achieved. For further deposit, the depot may need to continue receiving the drug for another 2 months.

See also: How to take with a lack of iron in the body analog - Malto.

Contraindications

• thrombosis and thrombophlebitis;
• parallel reception of glands containing iron, problems with the absorption of iron in the body;
• sugar diabetes and fructose intolerance;
• hemosiderosis and hemochromatosis;
• stenosis of the gastrointestinal bodies;
• other types of anemia;
• dosage allergies;
• children (up to 12 years old);
• urolithiasis and other serious diseases kidney.

With inflammation I. peptic disease The remedies are used only by appointment and under the supervision of the doctor.

Sideflines

Against the background of taking tablets, the sorbifer Duruless is possible the development of a number of pathological negative reactions from various organs and systems:

• Nervous system - dizziness, periodic headache, general weakness.
• Allergic reactions - a rash on the skin, its itching, specific pathological changes in the form of swelling and rash, reminiscent of burdens.
• The digestive system is nausea, periodic vomiting, painfulness In the area of \u200b\u200bthe abdomen, stool violation (constipation or diarrhea). It is rare to develop a peptic damage to the walls of the stomach, duodenum, as well as the narrowing (stenosis) of the esophagus.

Rarely marked skin hyperthermia. Negative pathological reactions are dose-dependent. With their development, the need to stop receiving tablets sorbifer Durules or dosage correction determines the attending physician.

Children, during pregnancy and breastfeeding

It is possible to use the drug sorbifer doruluce during pregnancy and during lactation by testimony. The drug is contraindicated to children and adolescents under 12 years old.

special instructions

During treatment, it is possible to change the color of the feces on the dark, which is due to the output of the iron not digestively. This reaction is a physiological norm, does not require adjusting the dosage or cancellation of the drug.

Medicinal interaction

It is not necessary to combine the reception of the drug with ciprofloxacin, norfloxacin, levofloxacin, offloxacin and moxifloxacin.

Not recommended combination food additives With the content of calcium and magnesium, captopril, clodronate, cimetidine, levodop, zinc, desaloksamin, methyldop, tetracycline, penicilinamine, thyroid hormones, pancreatin, ethanol and tocopherol with sorbifer. The gap between drug intake should be left at less than two hours.

The combination of the preparation with ascorbic acid can lead to an overdose of iron.

The drug absorption process is worsening when combined with milk, eggs, tea, coffee, juices, bread, products, rich vegetable fibers. Also for assimilation, oral contraceptives and chloramphenicol are negatively affected.

Analogs of drug sorbitol

The structure determines the analogues:

1. Vitrum Superstrass.
2. Enfamil with iron.
3. Biovital Elixir.
4. Ferro Folgamma.
5. Ferretab.
6. Peaks complex.
7. Licferre 100.
8. Malto Foul.
9. Ferrone.
10. Biofer.
11. Supradin Kids Junior.
12. Special Dragee Merz.
13. Totema.
14. Ferrone 35.
15. Gino Tartiferon.
16. Malto.
17. Stress formula with iron.
18. Ferrum Lek.
19. Heferol.
20. Multi Tabs asset.

For the treatment of iron deficiency, analogues are designed:

1. Endamil Premium 2.
2. Vitrum Zirkus.
3. Ferrogradmet.
4. Phenyuls 100.
5. Aloe Syrup with iron.
6. Tartiferon.
7. Actiferrin composites.
8. Ferroplex.
9. Hemoofer.
10. Ferrinat.
11. Woofer
12. Ferlam.

Vacation conditions and price

The average cost sorbifer (tablets No. 30) in Moscow is 387 rubles. Recommended by recipe.

Sorbifer Duruless should be stored in an inaccessible place for children at a temperature of 15 ... 25 C. The shelf life of the drug is 3 years.