Koldrex Junior Hotdrink Instructions for use, contraindications, side effects, reviews. Medicinal Reference Gootar Release Form and Composition

Powder for preparing a solution for intake (for children) heterogeneous, from white to pale yellow, with lemon smell; dissolves in 125 ml of hot water to form a turbid solution from yellow to yellow-green, which does not have on the surface of foam, with the smell of lemon; Perhaps the presence of a minor sediment.

Excipients: sodium sacharinat - 21.5 mg, sodium cyclamat - 31.5 mg, citric acid - 340 mg, sodium citrate - 215 mg, corn starch - 100 mg, sucrose - 1862.5 mg, aroma lemon 610399E - 100 mg, Curcumin dye (E100) - 3.5 mg, silicon colloid dioxide - 1 mg.

3 g - packets from laminate (10) - packs cardboard.

Medicinal interaction

Content

Respiratory diseases are easier to treat at the first manifestations. Having found a cold or infection symptoms, you can apply Coldrex medication. Each form is freely sold in pharmacies. Therapy with this drug, while compliance with the dosing mode and manufacturer's prescriptions, does not cause negative reactions. To avoid adverse consequences, consult your doctor.

Instructions for the use of Colds

ColdRex medicine in most cases is well tolerated by patients, so doctors often recommend it at the first manifestations of respiratory ailments. So that the therapy is effective, the tool should be taken in strict accordance with the instructions. Retreats from the recommended dosing mode, consumption in the presence of contraindications can cause a number of negative consequences.

The composition of Coldrels

The drug is released in the form of tablets, syrup or powder soluble in water. Each form of medication has a specific composition:

Pharmacodynamics and pharmacokinetics

Features of the drug action are due to its composition. The active components of the drug have the following pharmacodynamics and pharmacokinetics:

• Paracetamol is an analgesic, the effect of which is based on inhibition of the synthesis of prostaglandins of the central nervous system. The substance influences the hypothalamus, has an antipyretic effect. Paracetamol is absorbed in the gastrointestinal tract, its biosynthesis occurs in the liver. The substance with urine is displayed.
• Ascorbic acid - fills the lack of vitamin C, characteristic of the initial stages of infectious ailments, normalizes the permeability of capillaries, strengthens immune system organism. The absorption of the substance occurs in the gastrointestinal tract, after which it is quickly transported along the tissues. The residues of acid ascorbic are derived when urinating.
• Caffeine has a stimulating effect on the central nervous system and the secretory function of the stomach, contributes to a decrease in platelet aggregation, extension of vessels, increased paracetamol anesthetic effect, increasing the diurea. After receiving inside the substance is easily absorbed. The maximum concentration of caffeine in the blood plasma occurs after 60 minutes. The semi-exploration period is 3.5 hours.
• Phenylephrine helps to relieve breathing, remove the edema of the nasal mucosa. Absorption occurs in the gastrointestinal gastrointestinal tract. The bioavailability of the substance during the reception is orally reduced. Phenylephrine is excreted with urine.

Indications for use

The drug is prescribed to relieve cold symptoms and flu. According to the instructions for use, the medication is struggling with several manifestations of diseases:

• pain in the muscles and joints;
• high body temperature;
• nasal mortgage;
• headache;
• chills;
• pain in the throat, sinuses of the nose.

Method of application and dosage

All forms of the Coldrex must be taken inside the manual specified in the manual. The recommended course duration and dosage of the drug should be carefully observed to reduce the risk of side effects. If it is necessary to increase the term of therapy, the detection of unwanted symptoms should be referred to as a specialist.

Colder Tablet

Children over 12 years old and adults are prescribed 2 Coldrels 4 times / day tablets. The child aged 6-12 years is shown on 1 pill four times a day. The recommended dose of the drug is prohibited. The maximum duration of cold and influenza therapy using tablets is 5 days. When saving symptoms, you need to contact a specialist for changing the treatment strategy or increase the course of the medication.

Syrup

As an expectorant that contributes to the development of the secret of the bronchial glands, the Broncho syrup is prescribed to older patients, adults and children over 12 years of 10 ml 1-3 times / day. A viscous liquid must be pouring into a measuring cup to the desired mark and drink. For children from 3 to 6 years old, permitted one-time dose - 5 ml. Knight syrup is recommended to take 1 time / day before bedtime. Adult patients are assigned 4 dimensional spoons (20 ml). Children under 12 years old are recommended to give 10 ml of medication.

Cold Powder

The contents of the HOTREM or MACHIGRIPP bags must be pouring a glass of hot water with a volume of 200 ml, stir until the powder is completely dissolved. Adults are recommended to take 1 sachet every 4-6 hours. Maximum number - 4 bags per day. Children over 12 years old are recommended to eat drink every 6 hours. During the day you should not drink more than 3 bags. The drug is prohibited to consume more than 5 days.

special instructions

Patients taking the drug must refuse to eat alcohol for a period of therapy to avoid toxic liver damage. Patients having addiction from alcohol, to use a medication is prohibited. The drug can cause dizziness, so at the time of treatment it should be abandoned from activities requiring increased concentration of attention, rapid psychomotor reactions (driving a car, management of complex and hazardous mechanisms).

During pregnancy

The period of tooling the child and breastfeeding is a contraindication to the use of the medication. To make a decision on the possibility of using a medicine for therapy of colds and viral diseases during pregnancy should a doctor. If treatment is necessary for a woman during lactation, it is recommended to stop breast-feedingSince paracetamol getting into the child's body can provoke a toxic effect.

Colder for children

Preparation B. childhood You should take strictly according to the instructions. In the line of medicines, the Koldrex junior is produced. He is prescribed to children aged 6 to 12 years. The tool is a powder that should be dissolved in 125 ml of hot water. It is recommended to drink 1 sachet every 4 hours. At the same time, the maximum dose of medication per day should not exceed 4 sachets. Therapy is allowed to continue no more than 5 days. If the symptoms of the disease did not disappear, you need to consult a doctor.

Medicinal interaction

Experts do not recommend simultaneous medication with beta-adrenoblockers, monoaminoxidase inhibitors, tricyclic antidepressants. Between the use of these medicines should take a break for at least 2 weeks. The adverse effect on the body can have combined use of Coldrels with the following drugs:

• Colestramine - the absorption rate of paracetamol is reduced.
• Rifampicin, barbiturates, zidovudine, carbamazepine, other inducers of microsomal hepatic enzymes - the possibility of developing the hepatotoxic effect is increasing.
• Isoniazide, cimetidine, hormonal contraceptives - the activity of caffeine increases, which can cause nervous excitement, a feeling of anxiety, a rapid heartbeat.
• Anticoagulants indirect action, Heparin, diuretics - the effectiveness of these funds is reduced.
• Metoklopramide, Domperidon - there is an excessively rapid absorption of paracetamol.

Side effects

When taking recommended doses, the drug is transferred to patients well. Long therapy may cause nephrotoxic or hepatotoxic effects. In the treatment, it is not recommended to use coffee or sturdy tea, because there is a risk of increasing the negative effect of caffeine. Coldrels in tablets rarely causes adverse reactions:

• bronchospasm (with a patient sensitivity to nonsteroidal anti-inflammatory means);
• thrombocytopenia;
• cardiopalmus;
• dizziness, nervous voltage, irritability, headache, insomnia;
• nausea, vomiting, liver dysfunction;
• skin rash, swelling of quinque, dermatitis, urticaria, anaphylactic shock, Stevens-Johnson syndrome;
• violations of the urine release process;
• glaudoma attack.

Overdose

If the patient exceeded the recommended dose of the drug, the reception of the medication should be stopped even in the absence of a deterioration in the state, then contact the hospital. Overdose by the Coldrels can manifest itself nausea, pallhery skin Pokrov, hepathonecosis, impaired liver function, vomiting, decrease in hunger intensity.

In adult patients, the toxic effect of paracetamol is detected after receiving 10-15 g of substance. In this case, it is possible to increase the activity of hepatic transaminases. For treatment, washing the stomach, the reception of sorbents, the introduction of N-acetylcysteine, Donators Sh-groups is prescribed. Exceeding the dose of the thermal hydrate can trigger the disorders of the tract - the patient will need symptomatic therapy.

Caffeine overdose is manifested by the increase in urination, arrhythmia, pain in the field of epigastria, sleep impairment, vomiting, increased nervous excitability, anxiety, tachycardia, cramps, tremor. In the event of severe arterial hypertension, the patient requires treatment of alpha blockers. The use of an excess amount of ascorbic acid can provoke abdominal pain, nausea, diarrhea. Patient with an overdose of vitamin C is a forced diurez, symptomatic therapy.

Contraindications of Coldrels

• leukopenia;
• individual intolerance to one or more substances that are part of the medication;
• diseases blood system;
• disorders of kidney and liver functions;
• diseases of the cardiovascular system of organic genesis;
• thrombophlebitis;
• epilepsy;
• insomnia;
• atherosclerosis of severe form;
• decompensated heart failure;
• glaucoma;
• alcoholism;
• ischemic disease hearts;
• anemia of pronounced;
• prostate hypertrophy;
• pregnancy and lactation period;
• hyperthyroidism;
• arterial hypertension in severe;
• thrombosis;
• pancreatitis B. acute form;
• the presence of a tendency to vascular spasms;
• bad heart conductivity;
• heavy diabetes.

Terms for sale and storage

The drug is allowed as a means of a non-prescription vacation. Store the medicine is required in a dry place at room temperature, you need to take care of children. The shelf life of the medication depends on the form of the issue and is 2-4 years from the date of manufacture.

Analogs

In the absence of means on the shelves of pharmacies, it can be replaced by other medicines. There are several drugs similar to the Coldrex in composition or properties:

• Aurora Hot Sip - a drug for the treatment of colds. Available in the form of a powder intended for the preparation of the solution. An analogue of the Colder is well tolerated by patients. The medicine has a number of contraindications, so before use you must carefully examine the instructions. Drink a hot solution made from the contents of the Aurora Sip and Water Package, you need 4 times / day, avoiding an empty stomach.
• Adjical - tablets designed to eliminate symptoms respiratory infections. The active components of the means are: paracetamol, caffeine, phenylephrine hydrochloride. Tablets have an analgesic, antipyretic, anti-edema and anti-allergic effect. Adzhikold has a small list of contraindications - it is prohibited to children under 6 years old, pregnant and lactating women, people with hypersensitivity to the drug components. Adults are prescribed 1-2 pills 3-4 times / day, children - 1 tablet 1-4 times / day.
• Coldrine - helps to cope with feverish syndrome, sharp rhinitis With colds I. infectious diseases. The tablet form is produced in the form of caffeine, paracetamol, chloropenamine, phenylephrine. The drug has many contraindications - before use it is recommended to consult a doctor. Adults must be taken 1-2 pills every 4-6 hours. Maximum dose - 12 tablets per day. Children - 1 pills with an interval of 4 hours (no more than 5 pieces / day). The maximum term of therapy is 1 week.
• Glycodine is a preparation with an expectorant action. The remedy in the form of syrup is released. The composition of the glycodine is represented by levomentol, the thermal hydrine, dextromethorophane with a hydrobromide. The drug has a minimum of contraindications. People S. bronchial asthma It should be taken with caution. Recommended dose for children - 1/4-1 / 2 h. 3 times / day. Adults need to take 5 ml four times per day.
• Koldkur Plus - tablets for symptomatic medium therapy and influenza, contain phenylephrine, acetaminophen, caffeine, chlorophenylamine. The tool has an antipyretic, anesthetic, vasoconductive actions. The medication cannot be used in arterial hypertension, during pregnancy, lactation, with individual intolerance of the components. Adults are shown 1 pills three times per day. Children need to drink 1/2 tablets 3-4 times / day. The maximum duration of therapy is 5 days.
• Neugrip - extended tablets applied during colds. They have anti-inflammatory, anti-allergic, vesseloring effects, remove the heat. Adults showing 1-2 pills 3-4 times / day. Dosage to children must install a doctor.
• Gripaut - an effective anti-inflammatory drug for the treatment of respiratory diseases. It is recommended to take no more than 4 pill per day, the maximum period of therapy is 5 days. The tool has a large number of contraindications and side effects.
• Maxikolide - released in the form of tablets and powder. Ingredients: phenylephrine, paracetamol, Vitamin S. Maxikov is shown to patients with flu and cold to relieve pain, heat, runny nose. It is shown to drink 1-2 pills four times / day. Maxikov has many contraindications - a preliminary consultation of a specialist is necessary.
• Fluucole - sachet and pills with antihistamine, analgesic, antipyretic effects. The medication removes the swelling of the nose, Malgia, fever. The contents of Sasha must be dissolved in water and take no more than 4 per day. Tablets Flucolt should drink 1 pc. Three times per day, swallowing the whole.
• Aidrink is a combined agent against symptoms of respiratory ailments. Active substances Are paracetamol and phenylephrine. It is necessary to take 1 sachet 3-4 times in 24 hours. The contents of the package should be diluted with hot water.
• Vix asset is released in the form of powder, syrup, balsam, nasal spray, esiphey tablets. Each type of medication has a certain composition and properties. Vix asset is designed for symptomatic flu therapy and colds. It is necessary to carefully comply with the recommendations on the reception specified in the instructions.
• Lexipa Max - applied when high temperatures, chills, headaches, nasal congestion, ritin. It should be taken inside, pre-dissolving in a glass of hot water. Recommended daily quantity - 4 bags.
• Paolen - contains caffeine and paracetamol. The medication removes pain and heat, improves well-being in colds. Maximum daily dose of paralen - 8 tablets. Course treatment - up to 10 days.
• Amicitron is an painful, antipyretic, vasoconductive powder for the treatment of manifestations of influenza and ARVI. It is allowed to receive no more than 3 sachets in 24 hours, after diluting the contents of hot water. It is necessary to clearly follow the instructions, since the amicitron has a large list of side effects.
• Axagrip - contains paracetamol, gyvifenesin, phenylephrine. The medication is designed to reduce fever, head and muscular pain, nasal congestion. Adults are recommended to accept no more than 8 tablets in 24 hours, drinking them with water. It is necessary to clearly follow the instructions in order to prevent overdose and side effects.
• Grippocyrtron is used for patient therapy suffering from viral diseases. The medication removes edema, the heat, fights with sneezing, itching in the nose, headache. From the powder contained in the bags, you need to cook a drink, mixing it with hot water. Use the resulting liquid is necessary every 4-6 hours.
• Multigrip is a combined antipple preparation containing paracetamol, ascorbic acid, phenylephrine. Eliminates the heads I. muscle pain, Rubber, nasal congestion, reduces body temperature. It is recommended to drink no more than 3 doses of the drug per day. For the preparation of drink, powder is dissolved in hot but not boiling water.
• Teraflu - its components are effectively struggling with heat, allergic manifestations, edema, pain with ORVI. The medication has vasoconstrictor, sedative, antitussive actions. Powder is used inside, having prepared a hot solution. The interval between receptions is 4 hours (no more than 4 bags / day).

This article allows you to familiarize yourself with the instructions for use. medicinal preparation Coldrex. Presented reviews of site visitors - consumers this medicine, as well as the opinions of medical professionals to the use of Coldrex in their practice. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effects, possibly not stated by the manufacturer in annotations. Analogs of the Coldshell in the presence of the available structural analogs. Use for the treatment of symptoms of cold and influenza in adults, children, as well as during pregnancy and breastfeeding. The composition and interaction of the drug with alcohol.

Coldrex - combined drug For the symptomatic treatment of sharp respiratory diseases.

Paracetamol has an antipyretic and analgesic effect. Eliminates fever, reduces headache, pain in the muscles and joints, which often accompany flu.

Phenylefrin hydrochloride - sympathomomethus, narrows the vessels of the mucous membrane of the nose and the incomplete sinuses, as a result of which swelling decreases and nasal breathing is facilitated.

Ascorbic acid fills the increased need for vitamin C with colds and influenza, especially in initial stages Diseases.

The active components of the drug do not cause drowsiness and do not disturb the concentration of attention.

Promethazine - histamine H1 receptor blocker. Eliminates the swelling of the mucous membrane of the nose and the upper respiratory tract, restoring the nasal breathing and reducing the amount of the nasal separated from the nose.

Dextromethorphan is an antitochetus that oppresses the excitability of the cough center and suppresses the cough of any origin.

Coldrels Broncho - reduces surface tension and adhesive sputum properties, which reduces its viscosity and facilitates removal from the respiratory tract. The use of the drug contributes to the transition of an unproductive cough into the productive.

Structure

Paracetamol + caffeine + phenylephrina hydrochloride + Teremphydrate + ascorbic acid (vitamin C) + excipients (Coldrel).

Paracetamol + phenylefrin hydrochloride + ascorbic acid + auxiliary substances (Hotrem, Maxgipp and Junior Hotdrink).

Paracetamol + Promethazine hydrochloride + dextromethorophane Hydrobromid + excipients (Knight).

Givephenesin + excipients (broncho syrup).

Pharmacokinetics

Paracetamol is quickly and almost completely absorbed from the gastrointestinal tract, the distribution in the body liquids is relatively uniformly. Metabolized mainly in the liver with the formation of several metabolites. The main amount of the drug is displayed after conjugation in the liver. In unchanged form, no more than 3% of the obtained dose of paracetamol is distinguished.

Ascorbic acid is well absorbed from the gastrointestinal tract. Distribution in the body tissues is wide. Metabolized in the liver, is displayed with urine in the form of oxalate and unchanged. Ascorbic acid, adopted in excessive amounts, is rapidly excreted unchanged with urine.

Phenylephrine is poorly absorbed from the gastrointestinal tract and exposed to metabolism at the first pass in the intestine and liver under the action of Mao. When taking phenylephrine inside the bioavailability of the drug is limited. It is excreted with urine almost completely in the form of a sulfuric acid conjugate.

Indications

Elimination of symptoms of cold and influenza:

• increased temperature bodies;
• headache;
• chills;
• pain in the joints and muscles,
• nasal congestion;
• dry cough;
• acute tracheitis;
• bronchitis of different etiology;
• sore throat;
• pain in the sinuses of the nose.

Forms of release

Tablets (Colder).

Powder for preparing a solution for intake (for children) (junior hotdrink).

Powder for preparing a solution for intake (hotrem and macgripp).

Syrup (Broncho and Knight).

Instructions for use and reception scheme

Pills

Adults and children over 12 years old are prescribed 2 tablets up to 4 times a day. Children aged 6-12 years old - 1 tablet up to 4 times a day.

Powder Junior Hotdrink

Children aged from 6 to 12 years old are prescribed 1 bag every 4 hours. Do not apply more than 4 bags within 24 hours. Do not exceed the specified dose. The maximum duration of application is not more than 5 days. If the symptoms are saved, a doctor consultation is required. The need to continue treatment is determined individually.

The contents of 1 packet pour into the mug, pour about 125 ml of hot water, stir until dissolution. If necessary, add cold water and sugar.

Hotrem and Maxgipp Powder

Children over 12 years old are prescribed 1 bag every 6 hours, but not more than 3 bags within 24 hours.

The contents of 1 packet must be poured into a glass with hot water (200 ml), stir up to complete dissolution, if necessary, you can add cold water or sugar.

The maximum duration of the drug is 5 days.

Broncho syrup

Adults (including older patients) and children under the age of 12 years old are prescribed in a single dose of 200 mg (10 ml). Syrup should be filled with the attached measuring cup until 10 ml and drink the drug. If necessary, a one-time dose can be taken again every 2-3 hours.

Children aged 3 to 12 years old are prescribed in a single dose of 100 mg (5 ml). It should be filled with syrup the accompanying measuring cup to a mark of 5 ml and drink the drug. If necessary, a one-time dose can be taken again every 2-3 hours.

Syrup Knight.

The drug takes only 1 time per day, at night, immediately before bedtime.

Adults (including older patients) and children over 12 years old the drug is prescribed in a single dose of 20 ml (4 spoons of 5 ml).

Children aged from 6 to 12 years old are prescribed in a single dose of 10 ml (2 spoons of 5 ml).

Side effect

• allergic reactions (skin rash, urticaria, angioedema edema);
• thrombocytopenia, leukopenia, agranulocytosis;
• irritation of the mucous membrane of the gastrointestinal tract;
• dry mouth;
• nausea, vomiting;
• diarrhea;
• headache;
• dizziness;
• bronchorate;
• insomnia;
• insignificant increase in blood pressure;
• heartbeat.

Contraindications

• genetic lack of glucose-6-phosphate dehydrogenase;
• blood system diseases;
• liver diseases;
• kidney disease;
• thyrotoxicosis;
• diabetes;
• arterial hypertension;
• heart disease (expressed stenosis of the mouth of aorta, acute myocardial infarction, tachyarhythmias);
• a benign prostatic hyperplasia;
• clotted glaucoma;
• simultaneous reception with other paracetamol-containing drugs;
• simultaneous reception of antidepressants, including Mao inhibitors and a period of up to 14 days after their cancellation;
• epilepsy;
• pregnancy;
• lactation (breastfeeding);
• children's age up to 18 years old (Maxgipp), up to 12 years old (hotroid), up to 6 years old (Knight and Junior Hotdrink), up to 3 years old (Broncho);
• increased sensitivity to ingredients included in the preparation.

Application in pregnancy and breastfeeding

The drug Coldrex is contraindicated to use during pregnancy.

If you need to use during the lactation period, it is necessary to resolve the issue of cessation of breastfeeding.

special instructions

The patient must be informed that if the symptoms of the disease remain after 5 days of the use of the drug, it should be discontinued and consulted with a doctor.

The drug should not be taken simultaneously with other preparations containing paracetamol, as well as other non-nancotic analgesics (sodium metamizole), nonsteroidal anti-inflammatory drugs (NSAIDs) (acetylsalicylic acid, ibuprofen), barbiturates, anticonvulsant drugs, rifampicin and chloramphenicol.

Caution should be taken by Koldrex simultaneously with methoclopramide, domperidone, skewers, indirect anticoagulants (warfarin).

Patients taking the drug Koldrex should be refrained from alcohol consumption. It is not recommended to prescribe a drug in chronic alcoholism.

Patients observing a diet with a reduced sodium content should be borne in mind that 1 of the Koldrex preparation package contains 0.12 g sodium.

When analyzes for determining the level of uric acid and glucose levels in the blood, a doctor should be prevented by a doctor about the use of the drug Coldrex, since the drug may distort the results of laboratory tests that estimate the concentration of glucose and uric acid.

Medicinal interaction

Paracetamol during reception for a long time enhances the effect of indirect anticoagulants (warfarin and other kumarins), which increases the risk of bleeding.

Inductors of microsomal oxidation enzymes in the liver (barbiturates, diphenin, carbamazepine, rifampicin, zidovudine, phenytoin, ethanol (alcohol), fluecinol, phenylbutazone and tricyclic antidepressants) increase the risk of hepatotoxic effects in overdoses and simultaneous reception with paracetamol.

Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxic action.

Paracetamol reduces the effectiveness of diuretic drugs.

Metoklopramide and Domperidon are increased, and the koligarine reduces the absorption rate of paracetamol.

Paracetamol enhances the effects of Mao inhibitors, sedatives, ethanol (alcohol).

Codery when taking with MAO inhibitors can lead to an increase in blood pressure.

Phenylephrine reduces the effectiveness of beta-adrenoblasts and antihypertensive drugs.

Tricyclic antidepressants enhance the sympathomimetic effect of phenylephrine, the simultaneous assignment of the halotan with phenylephrine increases the risk of development of ventricular arrhythmia.

Phenylephrine reduces the hypotensive action of guanetidine, which, in turn, enhances the alpha-adrenostimulating activity of phenylephrine.

Antidepressants, anti-parkinsonic agents, antipsychotic drugs, phenothiazine derivatives increase the risk of urine delay, dry mouth, constipation.

The simultaneous purpose of glucocorticosteroids (GKS) with phenylephrine increases the risk of glaucoma.

Analogs of the Drug Caldrex

Structural analogues of PO active substance:

• Fluuball Forte.

Analogs of PO pharmacological group (Anilides in combination):

• Agiccov;
• Angritict Maxim;
• Antigrippin;
• Antiflu;
• Antiflu Kids;
• APAP with plus;
• Brush;
• Vix asset symptomax;
• Gevadal;
• Flupex;
• Infpostad;
• Grippostad Hood Knight;
• Infpostad with;
• Gripopoflu from cold and influenza;
• Grippofl Extra from cold and influenza;
• Gripend;
• Gripend Chotaitiv;
• Gripend Zhotakiv Max;
• Dalone C;
• Dulleon with junior;
• Children's tilenol from cold;
• Dollarken;
• Ibucklin;
• Influblock;
• Influenza;
• Kaffetin;
• Kaffetin Cold;
• CodeLimik;
• Tsidact Flu Plus;
• Koldrex Maxgipp;
• Koldrex Knight;
• Koldrex Hotrem;
• Koldrex Hotrem with lemon taste;
• Coldrex Hotrem with lemon and honey taste;
• Koldrex Junior Hot Drink;
• Coldfrey;
• Cofofedon;
• Lexipa Lemon;
• Lexipa Max;
• Lexipa black currant;
• Maxikolov;
• Maxikid Rino;
• Mexavit;
• Migrenium;
• Migrenol;
• MULLINEX;
• Nex;
• Neofly 750;
• Nomagin;
• Padewiks;
• Panadein;
• Panadol Extra;
• Panochelin;
• Parakodimol;
• Paul Extra;
• Paracetamol Extra;
• Paracetamol Extra Children;
• Pentalgin;
• Pentafluzin;
• Plivalgin;
• Disorder;
• Passover Forte;
• Rhines;
• RINZASIP;
• Rynikold;
• Saridon;
• Salpadein;
• Salpadein Fast;
• Stophipripan;
• Stophipripan forte;
• Streamol Plus;
• Tylenol from cold;
• Teraflu;
• Teraflu from influenza and colds;
• Teraflu from influenza and cold surges;
• Therapy extractab;
• Toff plus;
• Triga d;
• Fastroom;
• Fastroom plus;
• Febrcenet;
• Femizol;
• Fervex;
• Ferwex for children;
• Ferwex from dry cough;
• Fervest rhinitis;
• Fluukoldin;
• Fluuballs;
• Fluecomp;
• Flyucp extratab;
• Flustop;
• Heirumat;
• Effergangan with vitamin C;
• UNISPAZ.

In the absence of analogues of drugs on the active substance, you can follow the links below on the disease, which helps the appropriate drug, and see the analogues on therapeutic effects.

Structure

1 Package Contains K \u003d Active Components:

• paracetamol 300 mg
• phenylefrin hydrochloride 5 mg
• ascorbic acid 20 mg

Form release

Powder for the preparation of a solution for intake (for children) heterogeneous, from white to pale yellow, with a lemon smell; dissolves in 125 ml of hot water to form a turbid solution from yellow to yellow-green, which does not have on the surface of foam, with the smell of lemon; Perhaps the presence of a minor sediment.

10 bags in the package.

pharmachologic effect

Combined drug for symptomatic treatment of sharp respiratory diseases.

Paracetamol has an antipyretic, analgesic effect.

Phenylefrin hydrochloride - sympathomomethus, narrows the vessels of the mucous membrane of the nose and the incomplete sinuses, as a result of which swelling decreases and nasal breathing is facilitated.

Ascorbic acid fills the increased need for vitamin C with colds and flu.

Indication to application

To eliminate the symptoms of ORZ and influenza in children aged 6-12 years, including:

• elevated body temperature;
• headache;
• chills;
• pain in the joints and muscles;
• feeling of nasal congestion;
• pain in the sinuses of the nose and throat.

Methods of application and dose

Children aged from 6 to 12 years old are prescribed 1 bag every 4 hours. Do not apply more than 4 bags within 24 hours. Do not exceed the specified dose.

The maximum duration of application is not more than 5 days. If the symptoms are saved, a doctor consultation is required. The need to continue treatment is determined individually.

The contents of 1 packet pour into the mug, pour about 125 ml of hot water, stir until dissolution. If necessary, add cold water and sugar.

Contraindications

• increased sensitivity to the components of the drug;
• severe liver diseases;
• severe diseases of the kidneys;
• diseases of the blood formation system;
• thyrotoxicosis;
• arterial hypertension;
• heart disease (expressed stenosis of the mouth of aorta, acute myocardial infarction, tachyarhythmias);
• prostate hyperplasia;
• clotted glaucoma;
• diabetes;
• genetic absence of glucose-6-phosphate dehydrogenase;
• sakaraz / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, because The preparation includes sucrose;
• simultaneous reception of tricyclic antidepressants, beta-adrenoblockers, Mao inhibitors and a period of up to 14 days after their cancellation;
• decent age up to 6 years.

special instructions

The drug should not be taken simultaneously with other preparations containing paracetamol, as well as other nonarcotic analgesics (sodium metamizole), NSAIDs (acetylsalicylic acid, ibuprofen), with other means to facilitate cold symptoms and flu, sympathomimetics (such as decongestants, remedy appetite , amphetamine-like psychostimulating agents), barbiturates, anticonvulsant drugs, rifampicin and chloramphenicol.

When analyzing the determination of uric acid and the blood glucose level in the blood, you should inform the doctor about the use of the drug Koldrex® junior, because The drug may distort the results of laboratory tests that assess the concentration of glucose and uric acid.

Before taking the drug, you need a doctor consultation in the case of:

• reception of metoclopramid, domperidone (used to eliminate nausea and vomiting) or swieraffin, used to reduce blood cholesterol concentration;
• reception of drugs to reduce blood coagulation (for example, warfarin);
• compliance with a diet with a reduced sodium content - each bag contains 0.12 g sodium.

In order to avoid toxic liver damage, paracetamol should not be combined with drugs containing ethanol.

Storage conditions

The drug should be stored in an inaccessible place at a temperature not higher than 25 ° C

Preparation for symptomatic therapy of sharp respiratory diseases

Active substances

Release form, composition and packaging

◊ Powder for preparing a solution for intake (for children) heterogeneous, from white to pale yellow, with lemon smell; dissolves in 125 ml of hot water to form a turbid solution from yellow to yellow-green, which does not have on the surface of foam, with the smell of lemon; Perhaps the presence of a minor sediment.

Auxiliary substances: sodium saccharity - 21.5 mg, sodium cyclamat - 31.5 mg, citrate acid - 340 mg, sodium citrate - 215 mg, corn starch - 100 mg, sucrose - 1862.5 mg, lemon flavor 610399E - 100 mg, Curcumin dye (E100) - 3.5 mg, silicon colloidal dioxide - 1 mg.

3 g - packets from laminate (10) - packs cardboard.

pharmachologic effect

Combined drug for symptomatic treatment of sharp respiratory diseases.

Paracetamolit has an antipyretic, analgesic effect.

Phenylephrina hydrochloride - sympathomometry, narrows the vessels of the mucous membrane of the nose and the incomplete sinuses, as a result of which the edema decreases and nasal breathing is facilitated.

Vitamin C Fills the increased need for colds and influenza.

Pharmacokinetics

Data on pharmacokinetics of the drug Koldrex Junior is not provided.

Indications

To eliminate the symptoms of ORZ and influenza in children aged 6-12 years, including:

• elevated body temperature;
• headache;
• chills;
• pain in the joints and muscles;
• feeling of nasal congestion;
• pain in the sinuses of the nose and throat.

Contraindications

• increased sensitivity to the components of the drug;
• severe liver diseases;
• severe diseases of the kidneys;
• diseases of the blood formation system;
• thyrotoxicosis;
• arterial hypertension;
• heart disease (expressed stenosis of the mouth of aorta, acute myocardial infarction, tachyarhythmias);
• prostate hyperplasia;
• clotted glaucoma;
• diabetes;
• genetic absence of glucose-6-phosphate dehydrogenase;
• sakaraz / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, because The preparation includes sucrose;
• simultaneous reception of tricyclic antidepressants, Mao inhibitors and a period of up to 14 days after their cancellation;
• decent age up to 6 years.

Carefullyit should be used the drug under benign hyperbilirubinemias, pheochromocytoma, diseases of peripheral vessels (Reyno syndrome).

Dosage

Children aged 6 to 12 years Assign 1 bag every 4 hours. Do not apply more than 4 bags within 24 hours. Do not exceed the specified dose. The maximum duration of application is not more than 5 days. If the symptoms are saved, a doctor consultation is required. The need to continue treatment is determined individually.

The contents of 1 packet pour into the mug, pour about 125 ml of hot water, stir until dissolution. If necessary, add cold water and sugar.

Side effects

Definition of side effects: Very often (≥1 / 10), often (≥1 / 100 and<1/10), нечасто (≥1/1000 и <1/100), редко (≥1/10 000 и <1/1000), очень редко (≥1/100 000 и <1/10 000).

Paracetamol rarely has a side effect.

From the hematopopitation system: Very rarely thrombocytopenia.

Allergic reactions: rarely - skin rash, urticaria, allergic dermatitis; Very rarely - anaphylaxis, reaction of hypersensitivity, incl. Angio-erect edema, Stevens-Johnson syndrome.

From the respiratory system: Very rarely - bronchospasm in patients sensitive to and other NSAIDs.

From the digestive system: Very rarely - nausea, vomiting, violation of the liver function.

From the CNS: Very rarely - dizziness, headache, insomnia.

From the senses:rarely - mydriasis, acute glaucoma attack in most cases in patients with a closedian glaucoma.

From the side of the cardiovascular system:rarely - tachycardia, heartbeat, increased blood pressure.

From the urinary system: Very rarely - dysuria, urination delay in patients with obstruction of the bladder outlet with prostate hypertrophy.

In case of any unwanted reactions, the patient must consult a doctor.

Overdose

In the event of an overdose of the drug Koldrex junior (even with well-being), the risk of delayed signs of serious liver damage should be taken into account.

SymptomsConditioned paracetamol: Within 24 hours - the pallor of the skin, a decrease in appetite, nausea, vomiting, abdominal pain. After 12-48 hours, signs of violation of the liver function may appear, signs of metabolic disorders and metabolic acidosis.

In the case of severe poisoning, heavy liver insufficiency can develop up to hepatic encephalopathy, coma and death. Acute renal failure with acute semicosis of the tubules, which is diagnosed by severe pain in the lumbar region, hematuria and proteinuria, can develop and without severe liver function. There are reports of cases of heart arrhythmias and pancreatitis in the overdose of paracetamol.

In the early period, symptoms can be limited only by nausea and vomiting and may not reflect the severity of overdose or the degree of risk of the damage in the internal organs.

Treatment:during the first hour after the intended overdose, it is advisable to appoint activated carbon inside. After 4 or more hours after the proposed overdose, it is necessary to determine the concentration of paracetamol in the plasma (the earlier determination of the paracetamol concentration may be unreliable). Specific antidote with paracetamol poisoning - acetylcysteine. The treatment of acetylcysteine \u200b\u200bcan be carried out up to 24 hours after receiving paracetamol, but the maximum hepatoprotective effect can be obtained in the first 8 hours after an overdose. After that, the effectiveness of the antidote drops sharply. If necessary, acetylcysteine \u200b\u200bcan be entered in / in. In the absence of vomiting, an alternative option (in the absence of a quick opportunity to obtain stationary assistance) is the purpose of methionine inside. Treatment of patients with a pronounced violation of the liver function 24 hours after receiving paracetamol should be carried out together with specialists of the toxicological center or specialized branch of liver disease.

Symptoms Conditioned phenylephrine : Irritability, headache, dizziness, insomnia, improved hell, nausea, vomiting, increased excitability, reflex bradycardia. In severe cases of overdose it is possible to develop hallucinations, confusion of consciousness, cramps, arrhythmias.

Treatment: Symptomatic therapy, with severe arterial hypertension, the use of alpha-adrenoblockers, such as fantolamine.

Symptomsconditioned ascorbic acid: Ascorbic acid in high doses (more than 3000 mg) can cause temporary osmotic diarrhea and disorders of the tract, such as nausea, discomfort in the area of \u200b\u200bthe stomach. The occurrence of an overdose ascorbic acid can be classified as a category of such that are caused by severe liver damage as a result of paracetamol overdose.

Treatment:symptomatic, forced diuresis.

Medicinal interaction

Paracetamolwhen receiving for a long time, enhances the effect of indirect anticoagulants (warfarin and other kumarins), which increases the risk of bleeding. An episodic reception of a single dose of the drug does not significantly affect the effect of indirect anticoagulants.

Inductors of microsomal oxidation enzymes in the liver (barbiturates, diphenin, carbamazepine, rifampicin, zidovudine, phenytoin, ethanol, fluemicinol, phenylbutazone and tricyclic antidepressants) increase the risk of hepatotoxic effects in overdoses and simultaneous reception with paracetamol.

Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxic action.

Paracetamol reduces the effectiveness of diuretic drugs.

Metoklopramide and Domperidon are increased, and the koligarine reduces the absorption rate of paracetamol.

Paracetamol enhances the effects of Mao inhibitors, sedatives, ethanol.

Phenylephrinwhen taking Mao inhibitors can lead to an increase in blood pressure.

Phenylephrine reduces the effectiveness of beta adrenoblasts and increases the risk of the development of arterial hypertension and violations from the cardiovascular system.

Tricyclic antidepressants enhance the sympathomimetic effect of phenylephrine, can increase the risk of side effects from the cardiovascular system.

The simultaneous use of halotan with phenylephrine increases the risk of ventricular arrhythmia.

Phenylephrine reduces the hypotensive action of guanetidine, which, in turn, enhances the alpha-adrenostimulating activity of phenylephrine.

Antidepressants, anti-parkinsonic agents, antipsychotic drugs, phenothiazine derivatives increase the risk of urine delay, dry mouth, constipation.

The simultaneous purpose of GKS with phenylephrine increases the risk of glaucoma.

With simultaneous use with digoxin and cardiac glycosides, it is possible to increase the risk of developing heart rate violations or a heart attack.

Vitamin Cwith simultaneous use with iron preparations, due to its reducing properties, it translates the trivalent iron into a divalent, which helps to improve its absorption.

With the simultaneous use of ascorbic acid increases the excretion of iron in patients receiving deferoxamine.

With simultaneous use with barbiturates, the prison is an excretion of ascorbic acid with urine.

Ascorbic acid in high doses can reduce the pH of urine, which, while simultaneously use, reduces the canalic reabsorption of amphetamine and tricyclic antidepressants.

With the simultaneous use of acetylsalicylic acid reduces the absorption of ascorbic acid about a third.

With simultaneous use with warfarin, it is possible to reduce the effects of warfarin.

With simultaneously use with tetracycline, the removal of ascorbic acid with urine increases.

special instructions

The drug should not be taken simultaneously with other preparations containing paracetamol, as well as other nonarcotic analgesics (sodium metamizole), NSAIDs (acetylsalicylic acid, ibuprofen), with other means to facilitate cold symptoms and flu, sympathomimetics (such as decongestants, remedy appetite , amphetamine-like psychostimulating agents), barbiturates, anticonvulsant drugs, rifampicin and chloramphenicol.

When analyzes for determining uric acid and glucose levels in the blood, you should inform the doctor about the use of the drug Koldrex junior, because The drug may distort the results of laboratory tests that assess the concentration of glucose and uric acid.

Before taking the drug, you need a doctor consultation in the case of:

• reception of metoclopramid, domperidone (used to eliminate nausea and vomiting) or swieraffin, used to reduce blood cholesterol concentration;
• reception of drugs to reduce blood coagulation (for example, warfarin);
• compliance with a diet with a reduced sodium content - each bag contains 0.12 g sodium.

In order to avoid toxic liver damage, paracetamol should not be combined with drugs containing ethanol.

Impact on the ability to control vehicles and mechanisms

In the event of dizziness, the patient should refrain from managing vehicles or other potentially hazardous activities that require the concentration of attention and speed of psychomotor reactions. Conditions and storage time

The drug should be stored in an inaccessible place at a temperature not higher than 25 ° C. Shelf life - 3 years.