Diphenhydramine tablets (form - tablets) belongs to the group antihistamines for systemic use. In the instructions for use, the following features of the drug are distinguished:

• Sold by prescription only
• During pregnancy: with caution
• When breastfeeding: with caution

Packaging

Diphenhydramine - official instruction by application

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Indications Contraindications Dosage Warnings Interactions Manufacturer

INSTRUCTION

by medical use drug

Registration number:

Trade name: Diphenhydramine

International non-proprietary name:

diphenhydramine

Chemical name: N, N-Dimethyl-2- (diphenylmethoxy) ethylamine hydrochloride

Dosage form:

pills

Active substance: diphenhydramine (diphenhydramine) - 0.05 g

Excipients: milk sugar (lactose), talc, potato starch, calcium stearate.

Description: tablets white flat-cylindrical with a chamfer.

Pharmacotherapeutic group:

antiallergic agent - H1-histamine receptor blocker.

ATX code

pharmachologic effect

First generation H1-histamine receptor blocker. Blocks Н1- histamine receptors and eliminates the effects of histamine mediated through this type of receptor. Action on central nervous system due to blockade of H 3 -histamine receptors in the brain and inhibition of central cholinergic structures. It has a pronounced antihistaminic activity, reduces or prevents histamine-induced smooth muscle spasms, increased capillary permeability, tissue edema, itching and hyperemia. Causes local anesthesia (when taken orally, there is a short-term numbness of the mucous membranes of the oral cavity), blocks the cholinergic receptors of the ganglia (reduces blood pressure) and the central nervous system, has sedative, hypnotic, antiparkinsonian and antiemetic effects. Antagonism with histamine is manifested to a greater extent in relation to local vascular reactions in inflammation and allergies than to systemic ones, i.e. lowering blood pressure. In people with local brain damage and epilepsy, it activates (even in low doses) epileptic discharges on the electroencephalogram and can provoke epileptic seizure... The sedative and hypnotic effects are more pronounced with repeated doses.

The onset of action is noted 15-60 minutes after ingestion, duration -12 hours.

Pharmacokinetics.

It is rapidly absorbed in the gastrointestinal tract. Bioavailability is 50%. ТСmах - 2040 min (the highest concentration is determined in the lungs, spleen, kidneys, liver, brain and muscles). Communication with plasma proteins - 98-99%. Penetrates the blood-brain barrier. It is metabolized mainly in the liver, partly in the lungs and kidneys. It is excreted from the tissues after 6 hours. The half-life is 4-10 hours. During the day it is completely excreted by the kidneys in the form of metabolites conjugated with glucuronic acid. Significant amounts are excreted in milk and may cause sedation in children infancy (a paradoxical reaction characterized by excessive excitability can be observed).

Indications for use

Allergic conjunctivitis, allergic rhinitis, chronic urticaria, itchy dermatoses, dermatographism, serum sickness, in the complex therapy of anaphylactic reactions, Quincke's edema and other allergic conditions.

Insomnia, chorea, Meniere's syndrome, motion sickness and air sickness, as an antiemetic.

Contraindications

Hypersensitivity, angle-closure glaucoma, prostatic hyperplasia, stenosing gastric ulcer and duodenum, cervical stenosis bladder, bronchial asthma, epilepsy.

Children under 7 years of age (for this dosage form).

Carefully - pregnancy, lactation period.

Method of administration and dosage

Inside. Adults and children over 14 years of age, 25-50 mg (1 / 2-1 tablet) 1-3 times a day. The highest single dose is 100 mg, the daily dose is 250 mg. For insomnia - 50 mg 20-30 minutes before bedtime. For motion sickness - 25-50 mg every 4-6 hours if necessary.

Children from 7 to 14 years old 12.5 - 25 mg (1 / 4-1 / 2 tablets) 1-3 times a day.

Side effect

Drowsiness, dry mouth, numbness of the oral mucosa, dizziness, tremors, nausea, headache, general weakness, decreased speed of psychomotor reaction, photosensitization, paresis of accommodation, impaired coordination of movements. In children, paradoxical development of insomnia, irritability and euphoria is possible.

Overdose

Symptoms: depression of the central nervous system, the development of excitement (especially in children) or depression, dilated pupils, dry mouth, paresis of the gastrointestinal tract, etc.

Treatment: there is no special antidote. Gastric lavage. If necessary - symptomatic treatment: drugs that increase blood pressure, oxygen, intravenous administration of plasma-substituting fluids.

Epinephrine and analeptics should not be used.

Interaction with other medicinal products

Strengthens the effect of ethanol and drugs that depress the central nervous system.

Monoamine oxidase inhibitors increase the anticholinergic activity of diphenhydramine.

Antagonistic interaction is noted when administered together with psychostimulants.

Reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning.

Enhances the anticholinergic effects of drugs with anticholinergic activity.

special instructions

Patients who are potentially dangerous species activities requiring increased attention and quick mental reactions, care should be taken. During treatment with diphenhydramine, sun exposure and the use of ethanol should be avoided.

It is necessary to inform the doctor about the use of this drug: the antiemetic effect can make it difficult to diagnose appendicitis and recognize the symptoms of overdose of others medicines.

In children from 7 months to 12 months, the drug can be used in the form of a powder prepared in the prescription-production departments of pharmacies, 3-5 mg 2-3 times a day.

Release form

Tablets 50 mg.

On 10 tablets in a blister strip packaging or in a blister strip packaging. 2, 3 or 5 blister packs, together with instructions for use, are placed in a cardboard box.

Shelf life

5 years. Do not use the drug after the expiration date.

Storage conditions

List B. In a dry, dark place and out of reach of children.

Vacation conditions

On prescription.

Manufacturing company / organization accepting claims:

Dalkhifarm OJSC,

680001, Khabarovsk, st. Tashkent, 22.

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Diphenhydramine - indications for use

2 tablets of diphenhydramine!

Diphenhydramine belongs to the first generation antihistamines. Able to have antispasmodic, local anesthetic and moderate ganglion blocking effects. The main active ingredient is diphenhydramine.

An important distinctive feature a medication is considered to be its ability to create a sedative effect, a bit reminiscent of the effect of antipsychotic formulations. Diphenhydramine in certain doses has a very pronounced hypnotic effect. In addition, the drug is known for its mild antiemetic effects.

Drug characteristics

Diphenhydramine is used in the following cases:

• from allergies;
• with angioedema, allergenic;
• from the gag reflex in women during pregnancy;
• during vasomotor rhinitis, hemorrhagic vasculitis, itching;
• to improve sleep, from sea and air sickness;
• from hyperacid gastritis and ulcers.

The medicinal composition has several forms of release:

• white powder;
• tablets (0.02; 0.03; 0.05 g);
• candles - for the treatment of children;
• sticks;
• solution packaged in ampoules or syringe tubes;
• gel composition for external use, pencils.

Diphenhydramine tablets are taken orally. The dosage for adult patients to improve sleep is 50 mg at night, for therapeutic therapy - from 30 to 50 mg, divided into no more than three doses. The treatment course in this case lasts one and a half to two weeks.

For smaller patients, the doses are different:

• up to one year of age - 2 - 5 mg;
• from 1 to 5 years - 5 - 15 mg;
• from 5 to 12 years old - 15 - 30 mg.

The solution is used for intramuscular and intravenous administration... In the first version for adults, the dosage is from 50 to 250 mg, and no more than 20 to 50 mg is injected into the vein by drip.

For external use, the medicine should be used no more than one to two times a day.

The cost medicinal product in pharmacy kiosks is from 11 Russian rubles and depends on the form of release and packaging.

Negative properties of the drug

Besides their positive qualities, Diphenhydramine also has a number of contraindications and side effects:

The medicine can cause sweating, photosensitivity, allergies, chills. In addition, diphenhydramine in any form is prohibited from being taken with alcoholic beverages. You can read more about the drug.

An overdose of this medication leads to serious consequences, becomes the cause of death.

Since the drug can have a narcotic effect, it is released in pharmacies strictly according to the doctor's prescription. That is why it will be very relevant to know the analogues of Diphenhydramine without a prescription.

What can be replaced

Analogues of Diphenhydramine in ampoules are Tavegil, Suprastin, Chloropyramine. The cost of Tavegil in ampoules is about 200 rubles. Suprastin in the form of injections costs about 150 rubles. Chloropyramine costs about 130 rubles. Their active ingredient is different, but the effect of these drugs is the same.

If a sane person does not independently replace the drug, which is used in the form of injections, without the recommendation of his attending physician, then patients often choose pills on their own. Although this is also unacceptable, since you can cause significant harm to your body. Therefore, we will consider several of the main analogs of Diphenhydramine tablets.

Kalmaben

Antihistamine. The active ingredient of the drug is diphenhydramine. Available in the form of white tablets. The medicine is intended for systemic use, has a hypnotic and sedative effect. In addition, the drug eliminates allergy symptoms. It is a good substitute for Diphenhydramine.

For patients over twelve years old, it is allowed to take one tablet orally, about half an hour before bedtime, with a sufficient volume of liquid. The therapeutic course can last no more than two weeks. If necessary, the doctor can prescribe a second treatment. Allergy medication is prescribed for the same age group. The dosage in this case is 1 tablet no more than three times a day. The treatment lasts one and a half to two weeks.

The most common side effects include drowsiness and impaired concentration. There is a possibility of general weakness, headaches, arterial hypotension. Sometimes in the oral cavity dryness can be felt, vision is impaired, nausea and a gag reflex appear, deviations in urine output are observed. There are rare cases when an allergy manifested itself on the surface of the skin.

Misuse of this medication leads to dependence on it.

In pharmacy kiosks, the medicine is dispensed by prescription. Its cost is from 8 Russian rubles.

From the reviews of patients who took Kalmaben, it follows that the drug can create an inhibition effect the next day after taking it. This is especially pronounced if the dream was short.

Dramina

Another analogue of diphenhydramine tablets without a doctor's prescription is a drug with an active substance called dimensionhydrinate. The medicine creates an antiemetic and anti-nausea effect, interferes with the synthesis of acetylcholine, eliminates dizziness, has a sedative, anti-allergenic, local anesthetic effect.

Appointed for:

• prevention or therapy of kinetosis, sea and airborne diseases;
• assisting in the elimination of emerging abnormalities in the vestibular apparatus;
• elimination of dizziness, nausea;
• used in the treatment of Meniere's disease.

Patients from the age of twelve are prescribed 50-100 mg no more than three times a day. When preventing kinetosis, it is recommended to take the same dose half an hour before the trip. Dramina is allowed to be taken per day in an amount not exceeding 400 mg.

Small patients, whose age category is from 1 to 6 years, prescribe from 12.5 to 25 mg of the drug, distributing this rate into three doses. Older children can be given 25-50 mg three times a day. The dosage of the drug can be set and adjusted by the attending physician. The medication should be taken before meals.

Do not use Dramina in patients with individual sensitivity to the components of the drug, suffering from epilepsy, seizures, dermatosis in acute form, children under one year old, women during pregnancy and nursing mothers.

Particular care must be taken in patients suffering from angle-closure glaucoma, hyperplasia, gastrointestinal ulcer, urethral neck obstruction.

In case of an overdose in the nose and oral cavity there is a feeling of dryness, breathing slows down, confusion appears in the mind. In such situations, it is recommended to urgently rinse the stomach, take activated charcoal.

In a pharmacy, this drug can be purchased without a prescription, its cost ranges from 130 Russian rubles. The price depends on the manufacturer and packaging.

Many patients assure that Dramina eliminates the symptoms, but does not cure the disease itself. Before taking this drug, you should consult a doctor who will determine the dosage that is right for you.

In any case, when choosing what can replace diphenhydramine, you should follow the recommendations of your doctor.

Diphenhydramine (Dimedrolum)- a domestic anti-allergic agent, which has been used for more than fifty years in medical practice... The drug belongs to the first

generation of antihistamines, and, despite the abundance modern medicines, still finds its application.

Now diphenhydramine is used more often with inpatient treatment (i / m) for relief of allergic reactions, as well as as part of the "triad" (analgin 2ml-50%, papaverine hydrochloride 2ml-2%, diphenhydramine 1ml-1% - they are drawn in one syringe, injected i / m, slowly), the indications for the appointment of which is pain syndrome, elevated temperature body. Diphenhydramine tablets are rarely prescribed due to side effects and lack of effectiveness.

Drug release form: tablets, powder (0.02; 0.05 g), ampoules with 1% solution, syringe tubes, suppositories (for children), gel for external use.

How does diphenhydramine work?

It has antiallergic, antihistamine, hypnotic, antiemetic effect. By blocking histamine receptors (H1), it prevents the development of allergic reactions, spasms of smooth muscles, reduces vascular permeability, eliminates tissue swelling, hyperemia, itching. It has an antispasmodic, local anesthetic effect, slightly lowers blood pressure. It has a hypnotic (sedative) effect.

The maximum concentration after using Diphenhydramine inside is after 1-3 hours. Metabolism occurs in liver cells. Penetrates into brain tissue, placenta, excreted with breast milk... Duration therapeutic action - 4-6 hours.

Indications for use

• Vasomotor rhinitis, hay fever, allergic conjunctivitis, acute iridocyclitis;
• Food allergies, itchy dermatoses, urticaria, angioedema (Quincke's edema);
• Serum sickness, capillarotoxicosis;
• Complex therapy bronchial asthma, anaphylactic shock, radiation sickness;
• "Premedication" before surgery;
• For sleep disorders, parkinsonism, chorea, seasickness, Meniere's syndrome.

How is diphenhydramine prescribed?

The method of application, according to the annotation, will depend on the age of the patient. For adults, diphenhydramine is prescribed orally 1-3 times a day, 30-50 mg, the duration of administration is 10-15 days. The maximum daily dosage is 250 mg, a single dose is 100 mg. In case of sleep disturbance - 50 mg 30 minutes before bedtime. For motion sickness, give 25-50 mg with an interval of 4-6 hours.

Children 2-6 years old are given 12.5-25 mg (maximum 75 mg / day), children 6-12 years old - 25-50 mg with an interval of 6-8 hours (maximum 150 mg / day). Intramuscularly appoint 50-250 mg, daily maximum dosage - 150 mg, single dosage - 50 mg.Diphenhydramine gel is applied to the affected skin several times a day.

Side effects and contraindications

Patients may be disturbed by general weakness, decreased attention, drowsiness, lack of coordination, headache, irritability, tinnitus, lowering blood pressure, tachycardia, anemia. There may also be nausea, dry mouth, vomiting, constipation, diarrhea, allergic reactions.

Diphenhydramine is contraindicated:

• With drug intolerance;
• When breastfeeding, pregnancy;
• Stomach and duodenal ulcer;
• Closed-angle glaucoma;
• Hypertrophy of the prostate;
• Bronchial asthma;
• Bladder neck stenosis;
• Diphenhydramine is not prescribed for children under 2 years of age;
• During treatment, do not drink alcohol, refrain from driving.

Overdose symptoms

Difficulty breathing, dry mouth, facial flushing, agitation or depression of the central nervous system may occur, and children may develop seizures. It is necessary to induce vomiting, flush the stomach, prescribe enterosorbents (for example, Activated carbon, Enterosgel, Polysorb, Laktofiltrum). Symptomatic treatment is recommended.

Can Diphenhydramine be prescribed during pregnancy, lactation?

During pregnancy, breastfeeding, Diphenhydramine is not used. The risk of complications for the fetus and newborn is high. New generation anti-allergic drugs have fewer side effects, but they can only be taken in consultation with a doctor.

Are there analogues of Diphenhydramine?

Similar pharmacological properties possess Tavegil, Suprastin, Pipolfen, also used to relieve allergic reactions. The cost of analogs is much higher than the price of Diphenhydramine, but there are fewer side effects when using them.

Antiallergic agents of the second and third generation: Zyrtec, Erius, Tsetrin, Claritin, Loratadin, are better tolerated, longer acting, do not cause drowsiness. Their price is higher than that of Diphenhydramine.

Synonyms

Diphenhydramine, Benadryl, Allergan B, Diphenhydramine hydrochloride, Allergival, Diphenhydramine, Restamine, Diabenil.

How to store diphenhydramine?

List B. Storage in a dark, dry place. Do not use after the expiration date. The storage period is 5 years.

Drug price

You can buy Diphenhydramine by prescription (List B). Average cost of a medicine in a pharmacy chain:

• Diphenhydramine, 10 tab. 50 mg each (package) - 4 - 7 rubles;
• Diphenhydramine, ampoules No. 10, 1% -1 ml (packing) - 20 - 24 rubles.

Dosage forms

solution for injection 1%, solution for intravenous and intramuscular injection 10mg / ml, solution for injection 10mg / ml

Manufacturers

unidentified company (Russia), AY SI EN October (Russia), AY SI EN Polypharm (Russia), Allergen Stavropol (Russia), Belvitamins (Russia), Belgorodvitamins (Russia), Belmedpreparaty (Belarus), Biomed (Russia), Biosynthesis ( Russia), Biostimulator (Ukraine), Veropharm / Belgorod branch (Russia), Veropharm / Voronezh branch (Russia), Voronezh-Vremya Pharm Production Company (Russia), Voronezhkhimfarm (Russia), Dalkhimfarm (Russia), Darnitsa Pharmaceutical firm (Ukraine) , Health to the People (Ukraine), Immunopreparation (Russia), Microgen N

PharmGroup

H1-histamine receptor blockers

International non-proprietary name

Diphenhydramine

Vacation procedure

Dispensed by prescription

Synonyms

Allergin, Diphenhydramine-Vial, Diphenhydramine-UBF, Diphenhydramine-UVI, Diphenhydramine hydrochloride

Structure

The active ingredient is diphenhydramine.

pharmachologic effect

Pharmacological action - antihistamine, antiallergic, anticholinergic, antiemetic, sedative, hypnotic, local anesthetic. Blocks histamine H1 receptors and eliminates the effects of histamine mediated through this type of receptor. Reduces or prevents histamine-induced smooth muscle spasms, increased capillary permeability, tissue edema, itching and hyperemia. It causes local anesthesia, has an antispasmodic effect, blocks the cholinergic receptors of the autonomic ganglia (lowers blood pressure). Blocks H3-histamine receptors in the brain and inhibits central cholinergic structures. It has a sedative, hypnotic and antiemetic effect. It is more effective in bronchospasm caused by histamine liberators (tubocurarine, morphine, sombrevin) and, to a lesser extent, in allergic bronchospasm. When taken orally, it is rapidly and well absorbed. Most of metabolized in the liver, less is excreted unchanged in the urine. It is well distributed in the body, passes through the BBB. It is excreted in milk and may cause sedation in infants. The maximum activity develops after 1 hour, the duration of action is from 4 to 6 hours.

Indications for use

Urticaria, hay fever, vasomotor rhinitis, itchy dermatoses, acute iridocyclitis, allergic conjunctivitis, angioedema, capillary toxicosis, serum sickness, allergic complications in drug therapy, transfusion of blood and blood-substituting fluids; complex therapy anaphylactic shock, radiation sickness, bronchial asthma, peptic ulcer stomach and hyperacid gastritis; colds, sleep disturbances, sedation, extensive injuries to the skin and soft tissues (burns, crush injuries); parkinsonism, chorea, seasickness and air sickness, vomiting, incl. during pregnancy, Meniere's syndrome; local anesthesia in patients with a history of allergic reactions to local anesthetic drugs.

Contraindications

Hypersensitivity, breastfeeding, childhood (neonatal period and prematurity state). Restrictions on use: Angle-closure glaucoma, prostatic hypertrophy, stenosing stomach and duodenal ulcers, pyloroduodenal obstruction, bladder neck stenosis, pregnancy.

Side effect

From the nervous system and sensory organs: general weakness, fatigue, sedation, decreased attention, dizziness, drowsiness, headache, impaired coordination of movements, anxiety, increased excitability (especially in children), irritability, nervousness, insomnia, euphoria, confusion , tremor, neuritis, convulsions, paresthesia; visual impairment, diplopia, acute labyrinthitis, tinnitus. From the side of cardio-vascular system and blood: hypotension, palpitations, tachycardia, extrasystole; agranulocytosis, thrombocytopenia, hemolytic anemia... From the digestive tract: dry mouth, numbness of the oral mucosa, anorexia, nausea, epigastric distress, vomiting, diarrhea, constipation. From the side genitourinary system: frequent and / or difficult urination, urinary retention, early menstruation. From the respiratory system: dryness of the nose and throat, nasal congestion, thickening of the secretions of the bronchi, tightness in chest and heavy breathing. Allergic reactions: - rash, urticaria, anaphylactic shock. Others: sweating, chills, photosensitivity.

Interaction

Sleeping pills, sedatives, tranquilizers and alcohol increase (mutually) oppression of the central nervous system. MAO inhibitors enhance and prolong the anticholinergic effects.

Overdose

Symptoms: dry mouth, shortness of breath, persistent mydriasis, facial redness, depression or agitation (more often in children) of the central nervous system, confusion; in children - the development of seizures and death. Treatment: induction of vomiting, gastric lavage, appointment activated carbon; symptomatic and supportive therapy against the background of careful monitoring of breathing and blood pressure.

Method of administration and dosage

Intramuscularly - 10-50 mg, maximum single dose - 50 mg, daily dose - 150 mg, intravenously drip - 20-50 mg (in 75-100 ml of isotonic sodium chloride solution).

special instructions

Not recommended for subcutaneous administration (irritating effect). Use with caution in patients with hyperthyroidism, increased intraocular pressure, diseases of the cardiovascular system, in old age. Should not be used while driving by drivers vehicle and people whose profession is associated with increased concentration of attention. During the treatment period, use alcoholic beverages.

Storage conditions

List B. In the dark place at room temperature.

In this article, you can read the instructions for using the drug Diphenhydramine... Feedback from website visitors - consumers are presented of this medicine, as well as the opinions of doctors of experts on the use of Diphenhydramine in their practice. A big request to actively add your reviews about the drug: did the medicine help or did not help get rid of the disease, what complications were observed and side effects, possibly not declared by the manufacturer in the annotation. Analogs of Diphenhydramine in the presence of available structural analogs. Use for the treatment of allergic attacks and conditions in adults, children, as well as during pregnancy and lactation.

Diphenhydramine - first generation H1-histamine receptor blocker. The effect on the central nervous system is due to the blockade of H3-histamine receptors in the brain and inhibition of the central cholinergic structures. Relieves spasm of smooth muscles (direct action), reduces capillary permeability, prevents and weakens allergic reactions, has local anesthetic, antiemetic, sedative effects, moderately blocks cholinergic receptors of autonomic ganglia, has a hypnotic effect. Antagonism with histamine is manifested to a greater extent in relation to local vascular reactions in inflammation and allergies than to systemic ones, i.e. decrease in blood pressure. However, with parenteral administration to patients with a deficit in circulating blood volume, a decrease in blood pressure and an increase in the existing hypotension are possible due to the ganglion blocking action. In people with local brain damage and epilepsy, it activates (even in low doses) epileptic discharges on the electroencephalogram and can provoke an epileptic seizure.

The action develops within a few minutes, the duration is up to 12 hours.

Pharmacokinetics

Penetrates the blood-brain barrier. It is metabolized mainly in the liver, partly in the lungs and kidneys. During the day, it is completely excreted by the kidneys in the form of metabolites conjugated with glucuronic acid. Significant amounts are excreted in milk and can cause sedation in infants (a paradoxical reaction characterized by excessive excitability can be observed).

Indications

• anaphylactic and anaphylactoid reactions (in combination therapy);
• quincke's edema;
• allergic reactions (urticaria, hay fever, angioedema);
• allergic conjunctivitis;
• vasomotor rhinitis;
• hemorrhagic vasculitis;
• serum sickness;
• itchy dermatoses;
• sleep disorders (monotherapy or in combination with sleeping pills);
• chorea;
• sea \u200b\u200band air sickness;
• vomiting of pregnant women;
• meniere's syndrome;
• premedication.

Release forms

Tablets 50 mg.

Solution for intravenous and intramuscular administration (injections in ampoules) 10 mg / ml.

Instructions for use and dosage

Ampoules

Intravenous or intramuscular.

For adults and children over 14 years of age intravenously or intramuscularly 1-5 ml (10-50 mg) 1% solution (10 mg / ml) 1-3 times a day; the maximum daily dose is 200 mg.

For children aged 7 months to 12 months, 0.3-0.5 ml (3-5 mg), from 1 year to 3 years, 0.5-1 ml (5-10 mg), 4-6 years, 1-1.5 ml (10-15 mg), from 7 to 14 years old, 1.5-3 ml (15-30 mg), if necessary, every 6-8 hours.

Pills

For adults inside - 30-50 mg 1-3 times a day. The course of treatment is 10-15 days. As a hypnotic - 50 mg before bedtime.

When taken orally, single doses for children under the age of 1 year - 2-5 mg; from 2 to 5 years - 5-15 mg; from 6 to 12 years old - 15-30 mg.

Side effect

• drowsiness;
• weakness;
• decrease in the speed of psychomotor reaction;
• violations of coordination of movements;
• dizziness;
• tremor;
• irritability;
• euphoria;
• agitation (especially in children);
• insomnia;
• dryness of the mucous membrane of the mouth, nose, bronchi (increased viscosity of sputum);
• hemolytic anemia, thrombocytopenia, agranulocytosis;
• decrease in blood pressure;
• tachycardia;
• extrasystole;
• violation of urination;
• hives;
• skin rash;

Contraindications

• hypersensitivity to diphenhydramine;
• angle-closure glaucoma;
• hyperplasia of the prostate;
• peptic ulcer of the stomach and duodenum, complicated by stenosis;
• stenosis of the bladder neck;
• epilepsy;
• children's age up to 7 months.

Application during pregnancy and lactation

Take with caution during pregnancy and lactation.

special instructions

During the period of treatment, it is necessary to refrain from engaging in potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions (driving a car, etc.).

During treatment with diphenhydramine (the active ingredient of the drug diphenhydramine), UV radiation and the use of ethanol (alcohol) should be avoided.

Drug interactions

Enhances the effect of ethanol (alcohol) and drugs (drugs) that depress the central nervous system.

Monoamine oxidase (MAO) inhibitors increase the anticholinergic activity of diphenhydramine.

Antagonistic interaction is noted when administered together with psychostimulants.

Reduces the effectiveness of apomorphine as an emetic drug in the treatment of poisoning.

Enhances the anticholinergic effects of drugs with m-anticholinergic activity.

Analogs of the drug Dimedrol

Structural analogues active substance:

• Allergin;
• Diphenhydramine Buffus;
• Diphenhydramine-Vial;
• Diphenhydramine-UBF;
• Diphenhydramine solution for injection 1%;
• Psylo balm.

Analogues in rendered therapeutic effect (antihistamines):

• Aviomarin;
• Alerza;
• Alerpriv;
• Allergodil;
• Allertek;
• Allerfex;
• Astemizole;
• Bonin;
• Bronal;
• Histaglobin;
• Gistaphen;
• Gifast;
• Diazolin;
• Dinox;
• Zyrtek;
• Zodak;
• Kestin;
• Claritin;
• Clemastine;
• Loratadine;
• Lotaren;
• Mebhydrolin;
• Parlazin;
• Peritol;
• Pipolfen;
• Primalan;
• Suprastin;
• Tavegil;
• Telfast;
• Pheniramine maleate;
• Fenistil;
• Fenkarol;
• Chloropyramine;
• Cetirizine;
• Cetrin;
• Erespal;
• Erius;
• Erolyn.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and see the available analogues for the therapeutic effect.