Biseptol - instructions for use, release forms, analogs and prices. Biseptol ® (Biseptol ®) Biseptol intravenous administration instructions for use

Reception of funds that have a strong antibacterial effect allows you to eliminate diseases caused by pathogenic fungi, protozoa, gram-positive and gram-negative bacteria. Biseptol tablets are a drug with a bactericidal effect: it provokes the death of a microbial cell by blocking synthesis folic acid, without which it loses the ability to divide. it medicine does not belong to the group of antibiotics. Biseptol is available in the form of tablets, syrup and suspension. The last two forms mentioned are usually recommended for the treatment of children. Each dosage form has peculiarities of reception and dosage, therefore, before starting treatment, it is necessary to obtain comprehensive specialist advice. Please note: the medication is available with a prescription.

Biseptol is a drug with an extensive range of action, belongs to the group of bactericides. It is prescribed to eliminate germs that give rise to infectious diseases

Characteristics of the drug

Biseptol tablets - combination drug, which is characterized by a wide spectrum of action. It contains sulfamethoxazole, which disrupts the synthesis of the acid necessary for the development of bacteria, as well as trimethoprim, a substance that enhances the effect of the first active component and prevents the reproduction of pathogenic microorganisms.

Biseptol is effective in many pathologies, the effect appears soon - on the second day of treatment, an improvement is noted

This medication is active against pathogens such as:

• gonococci;
• meningococci;
• chlamydia;
• salmonella;
• colibacillus;
• some types of fungi.

Note! Biseptol does not act on viruses, so it is not used to treat viral diseases. The drug is also not active against pathogens and leptospirosis, Pseudomonas aeruginosa, spirochetes.

This medication is produced not only in the form of tablets - Biseptol suspension, syrup and ampoules containing a concentrate are also available. Biseptol suspension is suitable for children; the drug contained in ampoules is used exclusively during inpatient treatment under the supervision of medical personnel.

Tablets and other forms of medication are quickly absorbed from the stomach, and their active components have the ability to penetrate into tissues and biological fluids of the body - into the kidneys, tonsils, lungs, bronchial secretions, cerebrospinal fluid.

The maximum concentration of the active components of the drug in the blood is observed 60 minutes after its administration.

Indications and contraindications for taking the drug

Biseptol treatment is effective in the treatment of acute infectious diseases respiratory tract, infections of the ENT organs and gastrointestinal tract, diseases urinary tract and organs of the reproductive system. Also, the use of the drug is advisable for infections skin and soft tissues.

Biseptol is prescribed for infectious and inflammatory diseases of the urinary and reproductive system

Indications for taking Biseptol are the following diseases and pathologies:

• acute and chronic;
• lung abscess;
• malaria;
• scarlet fever;
• brucellosis;
• toxoplasmosis;
• acne;
• brain abscess;
• pyoderma;
• salmonellosis;
• typhoid fever;
• osteomyelitis;
• cholera.

Even having an idea of \u200b\u200bwhat Biseptol helps from, you should not take it without a doctor's prescription. This drug has some absolute contraindications. These include:

• children's age up to 3 months (for taking a suspension) or 3 years (for taking pills);
• impaired renal function;
• hypersensitivity to the active ingredients of the medication;
• period of gestation and breastfeeding;
• disorders of hematopoiesis;
• deficiency of folic acid in the body;
• liver failure;
• cardiovascular failure.

Note! If the patient has previously experienced an allergic reaction to taking certain medications, Biseptol is prescribed with caution, and treatment in this case is carried out under the special supervision of a physician. Also, tablets are prescribed with caution in case of illness. thyroid gland, at an early and old age.

When a patient is advised to drink Biseptol, he is necessarily warned of the likelihood of adverse reactions... Although in most cases this drug is well tolerated by patients, the following undesirable manifestations may occur:

With long-term use of high dosages of Biseptol side effects may be more pronounced. Occasionally serious allergic reactions, possible development due to changes in the composition of the intestinal microflora

• nausea;
• abdominal pain;
• apathy;
• depression;
• dizziness;
• trembling fingers;
• an increase in the volume of urine excreted;
• feeling short of breath;
• pain in muscles and joints;
• temperature increase;
• chills;
• itchy skin.

Biseptol is contraindicated in patients with severe illnesses internal organs - liver, kidney, as well as hematopoietic disorders

Side effects, if any, are mild.

Note! Extra caution when treating with Biseptol, it is necessary to observe the elderly, as well as those suffering from alcoholism or malabsorption.

Biseptol tablets are available in a dosage of 120 and 480 mg. The difference between them is that the first type of drug contains sulfamethoxazole in the amount of 100 mg and trimethoprim in the amount of 20 mg; in a preparation with a dosage of 480 mg - 400 mg and 80 mg of substances, respectively.

Each package contains 20 tablets.

The instruction for Biseptol tablets prescribes the following:

• reception is carried out after meals;
• to prevent the formation of crystals in the urine, provoking urolithiasis, it is necessary to drink pills with plenty of water, and throughout the course of treatment, drink at least 2 liters of pure water daily;
• during therapy, limit exposure to direct ultraviolet rays;
• when taking tablets, adults and children should limit the intake of protein foods, which reduces the effectiveness of the drug;
• it is important to quit alcoholic beverages, which not only neutralize the effectiveness of the medication, but can also cause the development of allergic reactions.

Before starting treatment, the specialist must explain to the patient how to take Biseptol. The dosage of the drug depends on the existing disease:

• Biseptol for cystitis, other diseases of the urinary tract of an infectious nature, as well as chronic in adults, is taken according to the following scheme: 960 mg of the drug per day, which is equal to 2 tablets at a dosage of 480 mg or 8 tablets at a dosage of 120 mg. You need to take pills 2 times a day. Biseptol is taken in a similar way;
• with gonorrhea, the intake of 1920-2880 mg of the drug per day is indicated. The indicated dosage is divided into 3 doses per day;
• with diarrhea, it is recommended to take 960 mg of the drug, in two divided doses. 12 hours must pass between each of them.

The minimum period of use of the specified medication is 4 days. It is not recommended to continue therapy for more than 2 weeks, since prolonged use of Biseptol provokes a violation of the synthesis of folic acid, and this, in turn, can lead to - disorders of hematopoiesis.

During treatment, it is important not to exceed the dosage prescribed by the doctor. An overdose of Biseptol can cause the following symptoms:

An overdose of Biseptol can greatly affect general state sick. This is manifested by frequent headache and dizziness. In some cases - aseptic and depression. If you experience these symptoms, you should see a doctor.

• drowsiness;
• nausea and vomiting;
• fever;
• light-headedness;
• the appearance of blood in the urine;
• jaundice;
• depression;
• disorders of hematopoiesis.

When signs of an overdose appear, the patient is assisted in the form of gastric lavage, intramuscular injection folinate, acidification of urine.

Can children take Biseptol tablets?

Can Biseptol be used in childhood? If it is necessary to take this drug, Biseptol for children is recommended in the form of a suspension. It can be given to a baby from 3 months of age. Biseptol syrup is recommended to be given at the age of 1 year. As for the medication in tablets, it can be used starting from 3 years. Parents are often worried about whether Biseptol is an antibiotic or not. This remedy does not belong to the group of such drugs, but its use must be discussed with a doctor.

How many milligrams should be the dose of the drug? Instructions for the use of Biseptol for children provide the following:

• at the age of 3 to 5 years, the daily dose of tablets will be 240 mg (2 tablets with a dosage of 120 mg);
• children from 6 to 12 years old are given 480 mg of the drug per day (4 tablets of 120 mg or 1 at a dosage of 480 mg);
• at the age of 12 years and older, the permissible daily dose can reach 960 mg per day. The daily intake is divided by 2 times.

When taking Biseptol by a child, it is important for parents to monitor his condition. If adverse reactions occur, you should immediately contact a specialist. On the advice of a doctor, you can supplement the treatment with vitamins and biologically active additives, which mitigate the negative effect of the drug on the intestines and kidneys.

Analogs

Analogs of the drug Biseptol 480 according to the active substance are:

• Bactrim;
• Disepton;
• Intrim;
• Cotrimoxazole;
• Trimezole;
• Tsiplin;
• Sumetrolim;
• Oriprim;
• Duo-Septol;
• Kotrifarm;
• Berlocid;
• Bisutrim.

The price of Biseptol is from 27 to 40 rubles for a pack of tablets with a dosage of 120 mg and from 80 to 110 rubles for a pack of tablets with a dosage of 480 mg.

The drug is dispensed exclusively with a doctor's prescription and taken according to his instructions.

Attention to all who uses Biseptol 480: the instructions for use of the specified drug should be carefully studied! In no case should the dosage prescribed by the doctor be exceeded, otherwise there is a significant risk of side effects.

Taking medications is a part of a person's life, regardless of their age. Often, patients of different doctors are confronted with taking a combined bactericidal agent, which one is prescribed for diseases genitourinary system, the other - the respiratory system, the third - the gastrointestinal tract.

What does biseptol help from, how is it dangerous and can it be drunk by children?

Indications for use

Biseptol (Biseptol) - what is this remedy for? The list of indications is very long.

Respiratory diseases

• bronchitis (acute and chronic);
• pneumonia (pneumonia);
• purulent inflammation of the pulmonary membrane (pleura);
• abscesses, abscesses of the lungs;
• an increase in the lumen of the bronchi.

Inflammatory processes of the upper respiratory tract and sensory organs

• middle and inner ear (otitis);
• paranasal sinuses (sinusitis);
• laryngeal membrane (laryngitis);
• mucous membrane of the pharynx and / or larynx (pharyngitis, tracheitis);
• palatine tonsils (tonsillitis);
• maxillary sinus (sinusitis).

Infectious intestinal pathologies

• contagious bowel disease in acute form, accompanied by diarrhea with blood (dysentery);
• paratyphoid type A and B;
• cholera;
• typhoid fever.

Inflammation of the genitourinary system

Some sexually transmitted diseases

Infections of the resulting wounds.

Purulent-necrotic processes affecting bone and soft tissues.

The indications for use also include the prevention and treatment of pneumonia in patients with human immunodeficiency virus, the cause of which is yeast-like pneumocystis fungi.

Composition and form of release

The question is often asked: is Biseptol an antibiotic or not?

Its full name is "antimicrobial combined agent, antibacterial drug from the group of sulfonamides ". That is, the basis of the drug is an antimicrobial substance, the action of which is not to destroy the pathogenic microorganism, but to block the processes that allow it to multiply.

In this case - in blocking the synthesis of folic acid by the body itself, the lack of which leads to the self-destruction of bacteria and microbes.

It turns out that the medicine is not an antibiotic medicine, while it has a powerful antiseptic effect.

Release forms

Are there any contraindications?

The instructions for use prohibit its reception by patients with the following pathologies:

• cVS disease during an exacerbation;
• liver pathology;
• severe renal dysfunction;
• glucose deficiency (if the condition is genetically determined).

It is prohibited to use it in:

• gynecology - for women during pregnancy and nursing mothers;
• pediatrics - for children under 90 days of age, born prematurely and with an increased level of bilirubin in the blood (jaundice).

Like any medical supplies, an antiseptic should not be used in case of hypersensitivity to any of the components that make up it.

Under the strict supervision of a physician, in a hospital setting, use it for persons who have relative contraindications:

• suffering from intolerance to other drugs;
• elderly and young children;
• having a deficiency of vitamin B9;
• suffering from bronchial asthma.

Side effects

Instructions for the use of Biseptol indicate that taking it can cause a number of side effects:

Gastrointestinal tract

Neurological

• headache;
• tremor of the limbs;
• dizziness;
• oppression of the psycho-emotional state.

Kidney

• decrease in the daily volume of urine;
• inflammatory processes;
• the appearance of blood in the urine.

Respiratory system

• spasms of the bronchi;
• lack of air;
• coughing.

Changes in the composition of blood, displayed in clinical analyzes.

Skin rashes, including the development of malignant neoplasms.

Allergy symptoms

• quincke's edema;
• photosensitivity.

The reactions are weak (except for those suffering from HIV infection) and disappear immediately after the patient stops taking the medicine.

Interaction

Is it possible to take Biseptol at the same time as other drugs, because many drink pills for high blood pressure, contraceptive, antidiabetic and others.

With medicines

It is forbidden to prescribe simultaneously with anti-inflammatory:

• acetylsalicylic acid;
• phenylbutazone;
• derivatives of naphthyl propionic acid.

Able to act like activity enhancer:

• anticoagulants;
• drugs that lower blood sugar levels;
• the anticancer drug methotrexate;
• cramp-reducing Phenytoin.

Concomitant use with diuretics increases the risk of bleeding and allergies.

Means for increasing the acidity of urine contribute to the formation of sand in the kidneys.

The combination with barbiturates, drugs for the treatment of tuberculosis and phenytoin provokes a lack of vitamin B9.

Local anesthetic medications are capable of reducing the result of antiseptic treatment, and the drug itself levels the effect of contraceptives.

Treatment in conjunction with anti-malaria drugs significantly reduces the amount of hemoglobin in the blood.

With alcohol

The abstract does not contain information about the prohibition of taking with alcoholic beverages. However, it is strictly forbidden to take Biseptol to those adults who abuse alcohol.

This is due to the fact that ethanol increases the risk of developing side effects from the liver, an already weakened addiction, and this is fraught with serious complications, up to the death of the patient.

Alcohol reduces immunity and leads to the activation of pathogenic microflora, which makes the use of an antiseptic useless: the body becomes unable to help the drug fight bacteria, inflammation intensifies.

Are there any special conditions?

Not.

Overdose

1. Give the patient as much water as possible to drink.
2. If no more than two hours have passed since the reception, wash the stomach.

Method of administration and dosage

The tablets should be taken after meals. To reduce the risk of developing side effects from the urinary organs, drink plenty of fluids. Drinking plenty of fluids must be provided for the entire duration of therapy.

There are also food restrictions. You will have to refuse:

• beans;
• fat cheese;
• food of animal origin;
• beets;
• flour products;
• dried fruits.

The treatment regimen is prescribed according to the diagnosis.

1. Biseptol in the form suspensions allowed for both adults and children. In the first case, the dosage is 20 ml every 12 hours, in conditions high degree severity is allowed to increase to 30 ml.
2. Pills usually prescribed 2 pieces at a dosage of 480 mg twice a day with an equal time interval. The course of treatment is from 5 days to two weeks.
3. Injections adults also do 2 times a day, 10 ml of solution.

Biseptol for children in injections is dosed as follows:

• from 3 to 5 years old - 2.5 ml each morning and evening;
• from 5 to 12 years old - 5 ml every 12 hours.

Suspension is allowed from three months, syrup - from 1 year. The dosage is calculated based on the body weight: 30 and 6 mg of active ingredients per 1 kilogram of the child's weight. This method of administration should not exceed 7 days.

Analogs

Substitutes are divided into analogs according to their composition and therapeutic effect. The first include:

• Bactiseptol;
• Bactrim;
• Bebitrim;
• Groseptol;
• Co-trimoxazole;
• Oriprim;
• Raseptol;
• Soluseptol;
• Sumetrolim;
• Triseptol and others.

The list of the second includes:

• analogues from the group of sulfonamides;
• antibiotics;
• antiviral.

Conditions of release and storage, approximate price

You can buy Biseptol at all pharmaceutical outlets, if you have a doctor's prescription. Before discharging it, the doctor must determine exact dosage, be sure to indicate it in the form, write how many days to take.

The packaging allows storage of the medicine without a refrigerator for 5 years from the date of release. average price depends on the dosage of the tablets:

• 120 mg (20 pcs.) - 40 rubles;
• 480 mg (28 pcs.) - 90 rubles.

What patients say

According to reviews, it is an effective remedy, well tolerated. The list of adverse reactions is large, but rarely causes them. Children, even younger ones, tolerate it better than adults.

There are also patients whom he did not help. So, treatment acne turned out to be ineffective (this is confirmed by photos of patients before and after therapy), and patients with gonorrhea did not notice the effect.

Biseptol 480: instructions for use and reviews

Latin name: Biseptol 480

ATX code: J01EE01

Active substance: co-trimoxazole (sulfamethoxazole + trimethoprim)

Manufacturer: JSC "Warsaw Pharmaceutical Plant Polfa" (Poland)

Description and photo update: 22.10.2018

Biseptol 480 is an antimicrobial combined sulfonamide drug.

Release form and composition

The dosage form of Biseptol 480 is a concentrate for the preparation of a solution for infusion: a transparent, colorless or light yellow liquid with a characteristic smell of ethanol (5 ml in ampoules, in a cardboard box 2 contour packs or 10 ampoules without packaging).

The composition of the concentrate for 1 ml / 1 ampoule:

• active ingredients: sulfamethoxazole - 80/400 mg; trimethoprim - 16/80 mg;
• excipients: sodium hydroxide, sodium metabisulfite, propylene glycol, benzyl alcohol, ethanol, water for injection.

Pharmacological properties

Pharmacodynamics

Biseptol 480 is a combined antibacterial drug. The active ingredients in its composition are: sulfamethoxazole - an effective antimicrobial agent of medium duration of action, inhibiting the synthesis of folic acid by competitive antagonism with para-aminobenzoic acid; Trimethoprim is a bacteriostatic antibiotic that inhibits bacterial dihydrofolic acid reductase. Their combination gives a synergistic antibacterial action, and therefore the effectiveness of such a complex is much higher in comparison with the action of other drugs.

Biseptol 480 - antibiotic wide range actions; shows its activity against the following microorganisms: Streptococcus (Streptococcus pneumoniae), Neisseria gonorrhoeae (enterotoxogenic strains inclusive), Neisseria meningitidis, Staphylococcus, Klebsiella, Escherichia coli, Haemophilus influenzae, Proteus spobacter., (Salmonella typhi and Salmonella paratyphi inclusive), Vibrio cholerae, Bacillus anthracis, Listeria spp., Nocardia asteroides, Bordetella pertussis, Enterococcus faecalis, Pasteurella spp., Brucella spp., Mycobacterium spp. (Mycobacterium leprae inclusive), Enterobacter spp., Citrobacter, Legionella pneumonia, Providencia, selected Pseudomonas species (excluding P. aeruginosa), Serratia marcescens, Morganella spp., Yersinia spp., Chlamydia spp. (Chlamydia trachomatis and Chlamydia psittaci inclusive), Actinomyces israelii, Shigella, Toxoplasma gondii, Plasmodium spp., Pneumocystis carinii, Histoplasma capsulatum, Coccidioides immitis, Leishmania spp.

Microorganisms showing resistance to Biseptol 480: Corynebacterium spp., Mycobacterium tuberculosis, Pseudomonas aeruginosa, Leptospira spp., Troponema spp. and viruses.

The drug inactivates the vital activity of E. coli, leads to a decrease in the synthesis of riboflavin, thiamine in the intestine, nicotinic acid, other vitamins of group B. Duration therapeutic action - 7 hours

Pharmacokinetics

Biseptol 480 penetrates into the tissues of the body and its biological fluids quickly and is well distributed in them. The drug penetrates the blood-brain barrier (BBB), the histohematogenous barrier, is excreted in breast milk. Its concentration in urine and lungs significantly exceeds plasma concentration. In vaginal secretions, bronchial secretions, bones, saliva, tissues and secretions of the prostate gland, breast milk, middle ear fluids, bile, cerebrospinal fluid, aqueous humor of the eye, interstitial fluid sulfamethoxazole and trimethoprim accumulate to a lesser extent. Both active components are distributed in different ways: sulfamethoxazole - only in the extracellular space, and trimethoprim - both outside the cells and inside them. 66% of sulfamethoxazole and 45% of trimethoprim bind to plasma proteins.

Both drugs are metabolized in the liver. Sulfamethoxazole is metabolized to a greater extent, forming acetylated derivatives - metabolites that do not have antimicrobial activity.

Biseptol 480 is excreted by the kidneys both by glomerular filtration and by active tubular secretion. Up to 80% of the drug is excreted within 72 hours in the form of metabolites; unchanged 20% sulfamethoxazole and 50% trimethoprim are excreted. In urine, the concentration of active substances is higher than in blood plasma. Through the intestines, the drug is excreted in a small amount. The half-life (T1 / 2) for sulfamethoxazole is 9-11 hours, for trimethoprim - 10-12 hours. In children, this indicator is significantly less and depends on the child's age: in the first year of life, it is 7-8 hours, from 1 year to 10 years - 5-6 hours. T1 / 2 increases in elderly patients with impaired renal function.

Indications for use

• gastrointestinal tract infections: paratyphoid fever, typhoid fever, cholera, salmonella, dysentery, cholangitis, cholecystitis caused by enterotoxic strains of Escherichia coli gastroenteritis;
• infections of the organs of the reproductive and urinary systems in acute and chronic course: pyelitis, pyelonephritis, urethritis, cystitis, epididymitis, prostatitis, chancre, gonorrhea, inguinal granuloma, lymphogranuloma venereum;
• infectious lesions of the ENT organs: tonsillitis, otitis media, laryngitis, sinusitis, scarlet fever;
• infections of the upper and lower respiratory tract: acute and chronic bronchitis, croupous pneumonia, bronchiectasis, pneumocystis pneumonia, bronchopneumonia, lung abscess, pleural empyema;
• infections of the skin and soft tissues: pyoderma, acne, furunculosis, wound infections and abscess, infection after surgery;
• other infectious diseases: sepsis, toxoplasmosis, acute brucellosis, osteoarticular infections, osteomyelitis, malaria (Plasmodium falciparum), South American blastomycosis, whooping cough (as part of complex treatment).

Contraindications

Absolute contraindications:

• liver failure;
• renal failure with creatinine clearance (CC) less than 15 ml / min;
• megaloblastic anemia due to a deficiency of vitamin B 9 (folic acid), aplastic anemia, agranulocytosis, B 12 deficiency anemia, leukopenia;
• deficiency of glucose-6-phosphate dehydrogenase;
• hyperbilirubinemia in children;
• intramuscular administration of the drug to children under 6 years of age;
• neonatal period and age up to 2 months;
• period of pregnancy and lactation;
• individual hypersensitivity to sulfa drugs, trimethoprim and (or) other components of Biseptol 480.

The drug is used with caution in case of vitamin B 9 deficiency, bronchial asthma, impaired liver / kidney function, thyroid diseases.

Instructions for the use of Biseptol 480: method and dosage

The solution prepared from the Biseptol 480 concentrate must be administered intravenously (IV) by drop. Do not use the drug as a quick intravenous injection.

To dilute the Biseptol 480 concentrate, the following infusion solutions may be used: 5 and 10% dextrose solutions; 0.9% NaCl solution; 0.45% NaCl solution with 2.5% dextrose solution; Ringer's solution.

• children under 12 years of age: the daily dose is determined at the rate of 36 mg per kg of body weight and is divided into 2 administrations in equal amounts;
• children over 12 years old and adult patients: 960 mg (10 ml or 2 ampoules) 1 time in 12 hours; if necessary, it is allowed to increase a single dose to 1440 mg (15 ml or 3 ampoules), 2-3 times a day.

• 5 ml (1 ampoule) of the drug - 125 ml of infusion solution;
• 10 ml (2 ampoules) of the drug - 250 ml of infusion solution;
• 15 ml (3 ampoules) of the drug - 500 ml of infusion solution.

The prepared solution of Biseptol 480 should not be mixed with infusion solutions other than those listed above, or with other drugs.

Patients with renal failure with QC from 15 to 30 ml / min, the dose of the drug is reduced by 1/2 of the average therapeutic.

Side effects

When used according to indications in compliance with the dosage regimen, Biseptol 480 is usually well tolerated by patients, but such side effects:

• central nervous system: headaches, dizziness; in some cases - apathy, depression, tremor, aseptic meningitis, peripheral neuritis;
• Gastrointestinal tract: vomiting, nausea, diarrhea, anorexia, abdominal pain, gastritis, glossitis, stomatitis, increased activity of liver enzymes, cholestasis, hepatitis, pseudomembranous enterocolitis, liver necrosis;
• respiratory system: bronchospasm, infiltration of lung tissue;
• hematopoietic organs: rarely - leukopenia, neutropenia, thrombocytopenia, agranulocytosis, megaloblastic anemia, hypoprothrombinemia;
• urinary system: impaired renal function, interstitial nephritis, polyuria, hematuria, crystalluria, hypocreatininemia, increased urea levels, toxic nephropathy with a decrease in urine output to oliguria and anuria;
• musculoskeletal system: myalgia, arthralgia;
• hypersensitivity reactions: rash, pruritus, erythema polymorphism, exfoliative dermatitis, photosensitivity, allergic myocarditis, hyperthermia, redness of the sclera, Quincke's edema;
• reactions at the injection site: soreness, thrombophlebitis;
• others: hypoglycemia.

Overdose

Symptoms of an overdose of Biseptol 480 are intestinal colic, nausea, vomiting, headache, dizziness, depression, fainting, drowsiness, confusion, fever, blurred vision, crystalluria, hematuria; due to prolonged overdose, leukopenia, thrombocytopenia, jaundice, megaloblastic anemia are possible.

To treat the condition, you must:

• flush the patient's stomach;
• ensure the administration of drugs that cause acidification of urine to enhance the elimination of trimethoprim;
• increase fluid intake;
• to eliminate the effect of trimethoprim on the bone marrow, inject intramuscularly calcium folinate at a dose of 5–15 mg / day;
• to stimulate erythropoiesis when trimethoprim inhibits the hematopoietic functions of the bone marrow, inject intramuscularly folic acid preparations at a dose of 3–6 mg / day, for 5–7 days;
• if necessary, carry out hemodialysis.

special instructions

When using Biseptol 480 in patients with acquired immunodeficiency syndrome (AIDS) who use co-trimoxazole for the treatment of pneumocystis pneumonia, such unwanted effectslike hyperthermia, skin rashes, leukopenia.

It is advisable to determine the concentration of sulfamethoxazole in plasma every 2-3 days immediately before the next infusion; if its value is\u003e 150 μg / ml, then therapy should be interrupted until the plasma indicator drops to 120 μg / ml.

Long-term treatment is required under systematic supervision functional state liver and kidney, as well as indicators of peripheral blood.

In order to prevent crystalluria in patients, it is necessary to maintain the volume of excreted urine in a sufficient amount.

Due to the deterioration of the filtration function of the kidneys, the likelihood of allergic and toxic complications increases significantly when using sulfonamides.

Against the background of treatment, it is inappropriate to eat foods containing para-aminobenzoic acid (PABA) in large quantities - tomatoes, carrots and green parts of vegetables ( cauliflower, spinach, legumes).

Due to the possible increase in photosensitization when using Biseptol 480, excessive solar and artificial ultraviolet radiation should be avoided.

Influence on the ability to drive vehicles and complex mechanisms

The drug has no effect on the ability to perform types of work that require a high concentration of attention and speed of psychomotor reactions.

Application during pregnancy and lactation

According to the instructions, Biseptol 480 is contraindicated in pregnant and lactating women.

Childhood use

The appointment of Biseptol 480 is contraindicated in premature babies, newborns and infants up to the 2nd month of life.

With impaired renal function

• renal failure with QC< 15 мл/мин – противопоказано применение Бисептола 480;
• renal failure with CC 15-30 ml / min - it is recommended to use 1/2 of the average therapeutic dose.

For violations of liver function

The appointment of co-trimoxazole is contraindicated in liver failure.

Use in the elderly

Elderly patients receiving treatment with Biseptol 480 are recommended to additionally prescribe folic acid at a dose of 3–6 mg / day; antimicrobial activity this combination does not significantly violate the drug. Treatment of elderly patients with suspected baseline folate deficiency requires special care.

Drug interactions

The Biseptol 480 concentrate is pharmaceutically compatible with the following solutions: 5 and 10% dextrose (glucose) solutions; 0.9% NaCl solution; 0.45% NaCl solution with 2.5% dextrose (glucose) solution; Ringer's solution.

Possible drug interactions Biseptol 480 with other substances / preparations:

• phenytoin, oral hypoglycemic agents, warfarin derivatives: their effect is enhanced, prothrombin time and the duration of bleeding are prolonged;
• diuretics (including thiazide diuretics): the risk of thrombocytopenia increases in elderly patients;
• cyclosporine: its concentration in the blood decreases;
• drugs and solutions containing bicarbonates: simultaneous intravenous administration with co-trimoxazole is prohibited;
• indirect coagulants: their anticoagulant activity increases;
• hypoglycemic agents and methotrexate: their effectiveness is increased;
• rifampicin: reduces the T1 / 2 of trimethoprim;
• phenytoin and warfarin: the intensity of hepatic metabolism decreases and their effect increases; T1 / 2 of phenytoin is extended by 39%;
• pyrimethamine (at doses\u003e 25 mg per week): increases the likelihood of megaloblastic anemia;
• diuretics (mainly thiazide): increase the risk of thrombocytopenia;
• procaine, procainamide, benzocaine, other drugs, as a result of hydrolysis of which PABA is formed: reduce the effectiveness of co-trimoxazole;
• barbiturates, phenytoin, para-aminosalicylic acid (PASK): increase the manifestations of folic acid deficiency;
• hexamethylenetetramine, vitamin Cothers medicinal substancesacidifying urine: increase the likelihood of developing crystalluria;
• salicylates: enhance the effectiveness of the drug;
• cholestyramine: inhibits the absorption of co-trimoxazole, so it must be taken 1 hour after or 4-6 hours before using Biseptol 480;
• oral contraceptives: their reliability decreases due to the suppression of the intestinal microflora and a decrease in the intestinal-hepatic circulation of hormonal compounds.

Between diuretics (furosemide, thiazides, etc.) and hypoglycemic drugs for oral administration (sulfonylurea derivatives) on the one hand and sulfonamides on the other, a cross-allergic reaction may develop.

Analogs

Biseptol 480 analogues are Co-trimoxazole, Bactrim, Briefseptol, Bi-Septin, Dvaseptol, Metosulfabol, etc.

Terms and conditions of storage

Store in a dry place at a temperature not exceeding 30 ° C. Keep out of the reach of children.

The shelf life is 5 years.

The preparation contains a combined active substance Co-trimoxazole , which in turn consists of substances sulfamethoxazole (200 mg for suspension and 100 mg (400 mg) for tablets) and (40 mg for suspension and 20 mg (80 mg) for tablets).

Additional funds

For suspension: purified water, macrogol, sodium carmelose, propylene glycol, propyl parahydroxybenzoate, aluminum magnesium silicate, sodium saccharin, citric acid monohydrate, maltitol, sodium hydrogen phosphate dodecahydrate, methyl parahydroxybenzoate.

For tablets: propylene glycol, potato starch, methyl parahydroxybenzoate, talc, propyl parahydroxybenzoate, magnesium stearate, polyvinyl alcohol.

Release form

Available in tablet form, 120 (often also called "Children's Biseptol") and 480 mg active substances, in the form of a suspension (syrup).

pharmachologic effect

Bactericidal, antibacterial.

Is Biseptol an antibiotic or not? This product is not an antibiotic.

Pharmacodynamics and pharmacokinetics

Combined antimicrobial drug. The main active ingredient is (trimethoprim + sulfamethoxazole). What is it used for? Biseptol has a double blocking effect on bacterial metabolism. Trimethoprim has an inhibitory effect on the enzyme involved in the metabolism of folic acid, and converts dihydrofolate to tetrahydroflorate. Sulfamethoxazole has a bacteriostatic effect. In the complex, the components of the Biseptol preparation block the biosynthesis of purines and nucleic acids, without which the reproduction and growth of bacteria is impossible.

The active substances are actively absorbed from the digestive tract. They are excreted mainly through the kidneys.

What are these tablets and suspension from?

In general, the drug is prescribed for infectious lesions of the urinary tract: pyelitis, epididymitis, lymphogranuloma venereum, chancre, inguinal granuloma. Consider Biseptol which helps with body parts.

Indications for the use of Biseptol for gastrointestinal infections: paratyphoid , typhoid fever , cholangitis, (E. coli), cholangitis, salmonella.

Respiratory tract infections: croupous pneumonia, bronchiectasis, (acute and chronic), pneumocystis pneumonia,.

Infections of soft tissues, skin: furunculosis, wound infections, pyoderma ... IN complex therapy is used to treat toxoplasmosis, malaria, South American blastomycosis, acute brucellosis.

Contraindications

Aplastic anemia, leukopenia, agranulocytosis, B12-deficiency anemia, severe disorders in the renal / hepatic systems, hyperbilirubinemia in children. With caution, Biseptol is prescribed for, a lack of folic acid, thyroid diseases.

Side effects

Nervous system: dizziness, headaches, rarely depression, aseptic, peripheral neuritis.

Respiratory system: pulmonary infiltrates, bronchospasm.

Digestive system: dyspeptic disorders, cholestasis, diarrhea, vomiting, loss of appetite, glossitis, epigastric pain, increased hepatic transaminases, stomatitis, pseudomembranous enterocolitis, hepatonecrosis,.

Hematopoietic organs: megaloblastic anemia, agranulocytosis, neutropenia, leukopenia, thrombocytopenia.

Side effects from the urinary system: crystalluria, interstitial nephritis, polyuria, toxic nephropathy with, oliguria, increased urea levels, hematuria, impaired renal function.

Locomotor apparatus: myalgia, arthralgia. , hypoglycemia, .

Instructions for the use of Biseptol (Way and dosage)

The dose of the drug in each case is prescribed by the doctor.

Biseptol tablets, instructions for use

Adults 960 mg once, or 480 mg for 2 doses. Severe infections: 480 mg three times. The course is 1-2 weeks.

With acute brucellosis the course of treatment is 3-4 weeks, paratyphoid and typhoid fever - up to 3 months.

Chronic infections: twice 480 mg tablets.

Instructions for use for children

For children, Biseptol is prescribed twice a day, a dose of 120 to 480 mg.

At the age of 3-5 years: 2 times 120 mg every 24 hours.

Suspension Biseptol, instructions for use

The syrup is used in the same way as the dosage of the tablets.

Overdose

Intestinal colic, dyspeptic disorders, headaches, dizziness, drowsiness, vomiting, confusion, fever, depression, hematuria , fainting, visual disturbances, leukopenia, fever, crystalluria ... With prolonged overdose, jaundice, megaloblastic anemia, thrombocytopenia, and leukopenia are noted. It is necessary to enter trimethoprim, calcium folinate intramuscularly at a dose of 5-15 mg / day. If necessary, hemodialysis is prescribed. There is no specific antidote.

Interaction

Biseptol enhances the effect of hypoglycemic drugs, indirect anticoagulants, methotrexate. The drug reduces the effectiveness and reliability of oral contraception. The risk of developing megaloblastic anemia increases when taken with pyrimethamine (more than 25 mg per week). Thiazides can lead to thrombocytopenia. The effectiveness of Biseptol is reduced procainamide , , ... The drug leads to the development of cross-allergy when taken simultaneously with oral hypoglycemic drugs. The lack of folic acid increases with the appointment of barbiturates, phenytoin, ... Crystalluria develops when taken , .

Terms of sale

Prescription required.

Storage conditions

Out of the reach of children at a temperature not exceeding 25 degrees Celsius.

Shelf life

No more than 3 years.

special instructions

Regular monitoring of the concentration of sulfamethoxazole in the blood is required. If the indicator is more than 150 μg / ml, then the treatment is stopped until reaching a value of 120 μg / ml and below. If the course of treatment is designed for a month or more, then regular monitoring of the blood condition is required. Upon appointment folic acid hematological changes are reversible. In AIDS patients, side effects are more common and pronounced. Biseptol is not recommended to be prescribed for and tonsillitis caused by beta-hemolytic streptococcus gr. AND.

Is Biseptol an antibiotic or not? According to the annotation, the drug is not an antibiotic.

A recipe in Latin might look something like this: Rp: "Biseptoli-420" D.t.d. No. 20 in tab.

There is no description of the drug on Wikipedia.

Biseptol for children

It is noted that the drug can be used from 3 months of age, and the doses will naturally vary. However, this should be done with caution and only as directed by your doctor. In some countries of the world, Biseptol for children is allowed to be used only from the age of 12.

Usually, a suspension can be prescribed from 3 months, tablets - from 2 years.

Instructions for Biseptol for children

At the age of 3 to 6 months, 2.5 ml of syrup is prescribed 2 times a day. The interval between doses should be at least 12 hours. From six months to 3 years, up to 5 ml of Biseptol suspension for children is taken twice a day.

From 3 to 6 years, the dosage is made equal to 5-10 ml twice, 6-12 years - 10 ml 2 times a day. From 12 years old, take 20 ml every 12 hours.

How do children take pills?

At the age of 2-5 years: 2 times 120 mg every 24 hours. From 6 to 12 years of age, 480 mg is used every 12 hours.

The course of treatment is 5-7 days. When using drugs for children, you should drink plenty of water.

Alcohol compatibility

It is impossible to predict the reaction of combination with alcohol. The use of these substances together is undesirable.

Biseptol's analogs

Matching ATX level 4 code:

Analogues are drugs: Bactiseptol , Biseptazole , Biseptrim , Groseptol , , Oriprim , Raseptol , Soluseptol , Sumetrolim , Triseptol .

Reviews about Biseptol

The remedy is very effective, especially for respiratory diseases. It has an excellent antibacterial effect. Of the minuses, side effects sometimes occurring should be noted. Do not use unless directed by your doctor.

Biseptol for children, reviews

It is considered very effective remedy to fight germs. Negative reviews in the treatment of Biseptol syrup for children are generally not found.

Reviews about Biseptol with cystitis

The drug is effective against cystitis, but do not forget about the side effects.

With angina

It is prescribed when it is impossible to take antibiotics. According to studies, microorganisms that cause angina began to lose sensitivity to this drug.

Biseptol price

The price of Biseptol in tablets of 120 mg is 35 rubles for 20 pieces. You can buy 480 mg tablets for 100 rubles for a pack of 28 pieces.

The price of Biseptol syrup is approximately 130 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies of UkraineUkraine
• Internet pharmacies in KazakhstanKazakhstan

ZdravCity

Biseptol tab. 480mg n28Polfa Pabianice

Biseptol tab. 120mg n20Polfa Pabianice

Biseptol suspension int. 240mg / 5ml 80mlMedana Pharma Terpol Group Joint Stock Company

Pharmacy Dialog

Biseptol 120 tablets 120mg No. 20

Biseptol suspension (vial 240mg / 5ml 80ml)

Biseptol 480 tablets 480mg No. 28

Eurofarm * 4% discount with a promo code medside11

Biseptol oral suspension 240 mg / 5 ml 80 mlMedana Pharma

Biseptol tablets 480 mg n28Pabyanitsk pharmaceutical plant Polfa

Latin name: Biseptol
ATX code: J01EE01
Active substance:
Manufacturer: Polfa, Poland
Pharmacy dispensing condition: On prescription
Price: from 90 to 500 rubles

Composition

Co-trimoxazole is composed of five parts sulfamethoxazole and one part trimethoprim. One tablet or ampoule contains (mg):

• Sulfamethoxazole
• Trimethoprim.

The concentrate contains the following additional components: sodium hydroxide and metabisulfite, benzyl alcohol, propylene glycol, ethanol.

Healing properties

"Biseptol" (480, 120 and 240 mg) is a broad-spectrum antimicrobial drug that belongs to sulfonamide drugs. The combination of active ingredients inhibits the synthesis of folic acid, which is responsible for metabolic processes in microbial cells, as well as their division. Co-trimoxazole does not kill pathogens of various diseases, but limits their reproduction, giving the immune system the ability to independently cope with pathogens. This explains the absence of a strong toxic effect during treatment with Biseptol.

The active substances of the drug quickly penetrate and are distributed in the body. If a dropper is placed, then the maximum concentration is reached within an hour. When using tablets, this time increases. The main part of the drug is excreted in the urine within 72 hours, a small part in the feces.

The drug is able to cope with about 40 types of pathogenic microorganisms, including streptococcal and staphylococcal infections, cholera vibrio, toxoplasma, salmonella, chlamydia, Escherichia coli and others. The drug has no effect on anaerobic and mycobacteria, as well as viruses.

"Biseptol" is used for the primary and secondary prevention of pneumocystosis and toxoplasmosis in HIV carriers.

Indications for use

The effect of the drug on a variety of pathogenic microflora makes it possible to use it for various infectious lesions:

• Respiratory tract - bronchitis at any stage, croupous, pneumocystis and bronchopneumonia, bronchiepathy
• Genitourinary system - cystitis, pyelitis, urethritis, pyelonephritis, prostatitis, lymphogranuloma venereum and inguinal granuloma, chancre, gonorrhea
• Gastrointestinal tract - paratyphoid and typhoid fever, cholera, salmonellosis, dysentery, gastroenteritis, cholecystitis, cholangitis
• ENT organs - scarlet fever, sinusitis, tonsillitis, otitis media, laryngitis
• Skin and tissues - the drug treats boils, acne, pyoderma, infections that develop in wounds
• Other diseases - osteoarticular infections, brucellosis, sepsis, whooping cough, malaria, toxoplasmosis, South American blastomycosis.

Patients suffering from HIV infection, held primary prevention pneumocystosis, if the number of CD4 + cells is less than 200/1 μl of blood or patients have a lesion of the oral mucosa with Candida fungus. All HIV-infected who have already suffered from pneumocystosis are shown secondary prophylaxis. The measures are canceled if, within 3 months, the number of CD4 + cells exceeds the value of 200/1 μl. "Biseptol" (480, 240, 120 mg) is used if prevention of toxoplasmosis in HIV infection is needed.

The medicine can be purchased in tablets and a concentrate from which a solution is prepared for intravenous infusion (droppers).

Average price from 30 to 110 rubles.

Biseptol tablets

A blister with tablets is placed in a cardboard box. The number of tablets in a package is 20 or 28 pcs. Color - white, let's say a yellowish tint. The dimensions of the tablets are 13 mm in diameter and 4 mm in thickness. On one side there is an imprint "Bs" and risk.

Mode of application

Biseptol tablets and concentrate are used to treat various diseasesas well as for holding preventive measures in those infected with HIV. The therapeutic regimen is determined by the age of the patient diagnosed and concomitant diseases, taking other medications. It is obligatory to take the medicine for 4-5 days. Additionally, therapy continues for another 2 days after the disappearance of the manifestations of the disease. Some diseases require long-term use drug. For example, typhoid fever is treated within 1-3 months, and acute brucellosis 3-4 weeks. A single dose of the drug can be increased up to 50% if the disease is severe or chronic.

Appointed after meals, washed down with water. The following standard regimen is recommended:

• Age from 12 years - 2 tablets (960 mg) twice a day every 12 hours. If the treatment lasts a long time, then 2 times a day, 1 tablet of the drug is taken
• Age from 6 to 12 years old - twice a day, 1 tablet
• Pneumonia is treated with a daily dosage of 100 mg sulfamethoxazole per kilogram of body weight. The medicine is taken 2 weeks daily at intervals of 6 hours
• In the treatment of gonorrheal infection, 2 g of sulfamethoxazole is taken per 1 kg of weight. The drug is prescribed twice a day after 12 hours.

For children under 6 years of age, it is advisable to use tablets with an active ingredient concentration of 120 mg.

Prevention of pneumocystis pneumonia is carried out according to the following scheme:

• Age from 12 years old - daily dose is 960 mg
• Age from 6 to 12 years - the dosage is calculated based on the surface area of \u200b\u200bthe body: 450 mg / m2. For reference: the average surface area of \u200b\u200bthe body of a person weighing 70 kg is approximately 1.8 m2.

For HIV patients, the prevention of pneumocystosis and toxoplasmosis is to take 2 tablets daily, even if side effects appear medium severity.

Average price from 40 to 500 rubles.

"Biseptol" in ampoules

Concentrate - a clear liquid in dark glass ampoules has a light yellow tint or no color. There is a smell of alcohol. The carton contains 10 ampoules of 5 ml each.

Mode of application

The dropper solution is prepared immediately before the procedure and is used within 6 hours. The administration time does not exceed one and a half hours, since during this time the achievement of the maximum effective concentration of the drug in the blood is ensured. The solution is injected slowly, intravenously, by drop. If a sediment or turbidity appears in the prepared liquid, then you cannot put a dropper.

The following are used as diluents:

• Dextrose solution 5%
• Sodium chloride solution 0.9%
• A solution of sodium chloride 0.45% and dextrose 2.5%
• Ringer's solution.

The drug is used in the following standard dosages:

• Age from 12 years - for one dropper, 2 ampoules (10 ml of medicine) are taken and diluted with 250 ml of saline. Infusion is performed 2 times every day
• Age up to 12 years - the therapeutic dose per 1 kg of body weight is 30 mg sulfamethoxazole + 6 mg trimethoprim per day. The resulting volume is used for 2 injections
• Severe infections - IVs are given every day 2-3 times. One infusion uses 15 ml (3 ampoules).

If a large intake of liquid is contraindicated for the patient, then a solution of increased concentration is prepared - 75 ml of the diluent is mixed with 5 ml of the drug.

If the kidneys do not cope with their functions, then "Biseptol" is discharged taking into account creatinine clearance (CC). For CC\u003e 30 ml / min, the usual treatment is used. For CC \u003d 15-30 ml / mi, half of the norm is prescribed. For QC<15 мл/мин препарат не используется.

Average price from 110 to 140 rubles.

"Biseptol", suspension

The suspension is intended for oral administration. Color from white to light cream. Sugar free. Has a light strawberry scent

Mode of application

Drink the suspension after meals with plenty of water.

Adults and children over 12 years old: from 960 mg to 1440 mg (depending on the severity of the disease) every 12 hours.

The period of taking the drug for urinary tract infections is 10-14 days, for exacerbation of chronic bronchitis - 14 days, for travelers' diarrhea and shigellosis - 5 days.

For children, the dose is calculated based on the disease. The approximate dose is 36 mg / kg per day.

The course of treatment for urinary tract infections and acute otitis media - 10 days, shigellosis - 5 days. For severe infections, the dose for children can be increased by 50%.

In acute infections, the minimum duration of treatment is 5 days; after the disappearance of symptoms, therapy is continued for 2 days.

After 7 days, changes are observed, if they have not come, adjust the dose or change the medicine.

960 mg every 12 hours drink suspension for the treatment of soft chancre (7 to 14 days).

For women with acute uncomplicated urinary tract infections, a single dose of 1920-2880 mg is recommended, if possible in the evening after meals or before bedtime.

For pneumonia caused by Pneumocystis carinii - 30 mg per kg 4 times a day with an interval of 6 hours for 14-21 days.

For the prevention of pneumonia, adults and children over 12 years old - 960 mg / day. For children under 12 years old, 450 mg every 12 hours for 3 consecutive days every week.

For other bacterial infections, the dose is selected individually, depending on individual indicators.

Contraindications

There are a number of conditions in which "Biseptol" of any form is not used:

• The child is under 3 months old
• There is an allergy to sulfonamides, active or auxiliary components of the drug
• Diagnosed with megaloblastic anemia, which is based on a lack of folic acid
• There is no possibility of monitoring the blood composition of a patient with liver or kidney dysfunction.

Pregnancy and breastfeeding

For pregnant women, the drug is contraindicated. Since the drug enters breast milk, when treating a nursing mother, the child should be transferred to artificial feeding.

Precautionary measures

When treatment times differ from the standard, the concentration of sulfamethoxazole in plasma is monitored. If therapy is carried out for more than a month, then the risk of changes in blood composition increases. To normalize the indicators, folic acid is prescribed. However, in HIV infection, the use of folic acid provokes the development of resistance of the causative agent of pneumocystosis to the active substance of the drug.

With caution, "Biseptol" (480, 120 and 240) is prescribed if there are:

• Thyroid disease or bronchial asthma
• Folate deficiency in elderly patients
• There is a risk of crystalluria - prevention is necessary, which consists in maintaining a normal amount of urine excreted.

When using biseptol, you need to exclude carrots, legumes, spinach, cauliflower, tomatoes, green parts of plants from the diet. You should not be under the sun for long.

Interaction with other medications

"Biseptol" is able to change the effect of some drugs:

• Warfarin, phenytoin, and hypoglycemic agents taken by mouth enhance their effects
• The concentration of cyclosporine when combined with biseptol decreases
• Oral contraceptives are becoming less reliable
• The use of diuretics (especially in the elderly) can cause thrombocytopenia.

Intravenous administration of biseptol together with medications that contain bicarbonates is unacceptable.

Side effects

Usually, patients tolerate the drug well, however, the occurrence of side effects can affect any of the systems of the human body:

• Digestive - nausea, diarrhea, decreased appetite, vomiting, abdominal pain, inflammation of the mucous membranes of the mouth and tongue, hepatitis
• Urinary - changes in kidney function, poly-, crystal- and hematuria, an increase in the concentration of urea and creatinine
• Respiratory - bronchospasm
• Bone - arthralgia, myalgia
• Nervous - headache, dizziness, sometimes depressive conditions, apathy
• An allergic reaction manifests itself in the form of a rash, itching, an increase in body temperature, the appearance of an inadequate reaction to sunlight and UV radiation from the skin and mucous membranes
• Hematopoiesis - a decrease in blood glucose levels, megaloblastic anemia, leuko-, neutro- and thrombocytopenia are possible.

With HIV infection, all side effects are much more frequent and stronger.

Overdose

The maximum dose of the drug leading to the onset of overdose symptoms has not been established. A single excessive intake of the drug can cause nausea, abdominal pain, dizziness, vomiting, confusion, crystalluria, visual impairment. Prolonged overdose is manifested by jaundice and blood changes.

If symptoms of an overdose appear, then you should rinse the stomach and provide plenty of drink. Calcium folinate, administered intramuscularly, will help neutralize the negative effect on the body of trimethoprim. The daily dosage ranges from 5 to 15 mg. Hemodialysis is possible.

Conditions and shelf life

Biseptol is stored in a place protected from light. It must be out of the reach of children. Storage temperature does not exceed + 25 ° С. The concentrate must not be frozen. The drug has been used for 5 years.

Analogs

The active ingredient co-trimoxazole is included in other drugs that have a similar effect on the human body.

F. Hoffmann-La Roche, Switzerland
Price from 70 to 400 rubles.

The drug is available in the form of a suspension and tablets "Bactrim Forte". The content of sulfamethoxazole is 200 mg, and the content of trimethoprim is 40 mg per 5 ml of the drug. "Bactrim" has a wide range of effects on pathogenic microflora.

pros

• The suspension can be taken by children from 3 months
• Measuring spoon included

Minuses

• Lots of side effects
• The drug should not be taken during pregnancy.

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Biosynthesis / Pharmstandard-Leksredstva / Skopinsky FZ, Russia
Price from 10 to 60 rubles.

The drug is available in the form of tablets, each of which contains 120 or 480 mg of the active substance, as well as in the form of a suspension containing 240 mg of co-trimoxazole per 5 ml.

pros

• Convenient form of administration in the form of a suspension and tablets with different concentrations of the active substance
• Low price

Minuses

• Negative effect on the hematopoietic system
• Extensive list of side effects.