Kvamatel analogues and prices. Application of the drug Kvamatel - comparison with analogues Application for violations of liver function

thanks

The site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. A specialist consultation is required!

Drug Kvamatel by pharmacological properties represents histamine receptor blocker type H2. This drug reduces the rate of production of hydrochloric acid, reducing the acidity of gastric juice. Thus, Kvamatel is used for the treatment of gastric ulcer and twelve duodenum, as well as to eliminate various digestive disorders caused by high acidity of gastric juice. The drug relieves not only the symptoms caused by increased acidity of gastric juice, but also reduces the production of hydrochloric acid, thus affecting the cause of the development of clinical signs.

Release form

Today Kvamatel is available in the following dosage forms:
1. Tablets of 20 and 40 mg.
2. Mini tablets 10 mg.
3. Lyophilisate for solution preparation.

Conventional tablets containing 20 mg and 40 mg of active ingredient are often referred to as "Kvamatel 20" and "Kvamatel 40". The lyophilisate is also known under the names - "Kvamatel in ampoules", "Kvamatel injections" or "Kvamatel solution". But tablets with a low content of the active ingredient - only 10 mg, are called "Kvamatel mini".

Kvamatel 20 tablets are available in packs of 28 pieces, Kvamatel 40 - 14 pieces each, and lyophilisate - 5 bottles per box. The lyophilisate is completed with a solvent - 5 vials with sterile saline.

Composition

Kvamatel tablets and lyophilisate contain as active substance famotidine, in various quantities:
1. Tablets - famotidine 20 or 40 mg.
2. Tablets Kvamatel mini - famotidine 10 mg.
3. Lyophilisate - famotidine 20 mg in one bottle.
All types of Kvamatel tablets contain the same excipients, among which the following have potential allergenicity:

• povidone K90;
• sodium carboxymethyl starch;
• corn starch;
• lactose monohydrate.

Lyophilisate for solution preparation contains as auxiliary components aspartic acid and mannitol.

Therapeutic effects and action

The active substance Kvamatel is a blocker of histamine H2 receptors. These receptors are located in the lining of the stomach and upper intestine. The activating effect on this type of receptor leads to an increased production of hydrochloric acid. You should know that H2 receptors are activated under the influence of gastrin, pentagastrin, betazol, caffeine, histamine and acetylcholine, as well as during the conduction of a nerve impulse along vagus nervethat develops in response to a signal that the stomach is full. This means that even after drinking a glass of water, histamine receptors of the H2 type are activated and the production of hydrochloric acid is increased, which, in excess, leads to indigestion and damage to the mucous membrane of the gastrointestinal tract.

Kvamatel blocks H2- histamine receptors, and thereby reduces the synthesis of hydrochloric acid. Thus, the acidity of the gastric juice is normalized. In addition, the effect of blocking histamine receptors leads to a decrease in pepsin activity.

The drug Kvamatel removes only the excess acidity of gastric juice, but does not affect the motility of the organ, which causes the timely evacuation of contents from the stomach into the duodenum. Also, the drug does not reduce the production of pancreatic enzymes, does not affect the synthesis of hormones. Kvamatel also has no effect on the activity of liver enzymes, as well as on the volume and rate of blood circulation in the portal vein system.

The effect of the drug develops one hour after ingestion, and lasts for 10 to 24 hours. When administered intravenously, Kvamatel has an effect within 30 minutes. Kvamatel's injections, given in the evening, suppress the basic secretion of hydrochloric acid for 10 to 12 hours, that is, all night.

Indications for use

Tablets Kvamatel 20 and 40 mg, as well as lyophilisate, have the same indications for use, which are due to therapeutic effect drug. Kvamatel mini tablets are used to relieve symptoms of increased acidity of gastric juice, which is not accompanied by the presence of pathology. In other words, lyophilisate and tablets are used to treat diseases, and Kvamatel mini is used to eliminate functional disorders.

So, tablets Kvamatel 20 and 40 mg and Kvamatel in ampoules are indicated for use in the presence of the following conditions:

• Aggravation peptic ulcer stomach and duodenum.
• Prevention of recurrence of gastric and duodenal ulcers.
• Treatment and prevention of any symptomatic ulcers of the stomach and duodenum (for example, while using Aspirin or Indomethacin, after suffering stress or surgical intervention etc.).
• Erosive gastroduodenitis.
• Indigestion due to increased acidity of gastric juice.
• Reflux esophagitis.
• Zollinger-Ellison Syndrome.
• Prevention of bleeding in organs digestive system.
• Prevention of gastric reflux with general anesthesia (Mendelssohn's syndrome).

Kvamatel mini tablets are specially designed for use in digestive disorders due to increased acidity of gastric juice. Therefore, this drug is indicated for use in case of acidic belching, heartburn and other unpleasant symptoms accompanying excessive acidity of gastric juice.

Kvamatel - instructions for use

Each dosage form of Kvamatel has its own characteristics of use. However, there are also general rules for all forms of medicine. First of all, consider general rules taking Kvamatel, and then the peculiarities of using injections and tablets.

The use of the drug erases the severity of the clinical picture, therefore it is able to disguise oncology. Due to the danger of not diagnosing cancer in time, it is necessary to undergo an examination before using Kvamatel and exclude the presence of any neoplasm in the stomach.

The use of Kvamatel should not be stopped abruptly, since in this case the risk of developing a withdrawal syndrome is high. This means that the dose of Kvamatel is gradually reduced, and only after that the drug is completely canceled.

If a person has concomitant liver pathology, it is necessary to take Kvamatel in reduced dosages, and under close medical supervision.

You can not use Kvamatel long time for the treatment of debilitated patients or people in a state of stress, since in this case there is a high risk of developing a stomach infection of a bacterial nature with its spread to other organs.

Between taking Kvamatel and drugs such as Itraconazole, Ketoconazole, antacids (Almagel, Gastal, etc.), there is a time difference of 2 hours. And first you need to take Kvamatel, and after 2 hours - the above drugs.

When planning a gastric acidity test and an allergy test (Prike's test), it is necessary to stop taking Kvamatel a day before the diagnostic manipulations. Otherwise, the results may be distorted and uninformative.

For the entire period of use of Kvamatel, you should refuse foods, drinks and medicines that irritate the gastric mucosa (for example, fried, spicy, salty, carbonated water, coffee, Aspirin, Indomethacin, Nimesulide, etc.).

While taking Kvamatel, you must be extremely careful if you have to do work that requires increased concentration of attention and speed of reactions. This includes driving carefully.

Overdose

An overdose of Kvamatel is possible and this condition manifests itself with the following symptoms:

• vomiting;
• motor excitement;
• shaking limbs (tremors);
• low pressure ;
• heart palpitations (tachycardia);
• collapse.

To eliminate an overdose, you must first remove the remnants of the drug from the body. For this purpose, gastric lavage is performed and / or vomiting is induced. Hemodialysis is not effective for removing the drug. After that, symptomatic remedies are used, depending on the developed clinic:
1. Convulsions - intravenous diazepam.
2. Rare heartbeat - inject atropine.
3. Arrhythmias - administer lidocaine.

Combination with other medicines

Kvamatel enhances the absorption of Amoxicillin, but reduces Itraconazole and Ketoconazole. Antacids (Almagel, Fosfalugel, etc.) reduce the absorption of Kvamatel. Combined use with drugs that inhibit hematopoiesis leads to a decrease in the number of blood neutrophils.

The above are the general rules for using Kvamatel, which apply to all dosage forms - pills, injections and Kvamatel mini. Now we will consider the specific dosages and rules for the use of each dosage form.

Kvamatel tablets

The tablets are taken orally with a little water. The dosages of Kvamatel and the duration of the course of treatment, depending on the pathology, are shown in the table:

Pathology	Dosages of Kvamatel	Duration of use
Peptic ulcer of the stomach and duodenum in the acute stage	40 mg once a day (taken in the evening) or 20 mg twice a day (morning and evening). If necessary, you can increase the daily dosage to the maximum values \u200b\u200b- 160 mg	Apply within 4 to 8 weeks
Prevention of relapse of gastric ulcer and duodenal ulcer	20 mg once a day, in the evening before going to bed	Apply within 2 - 3 weeks
Reflux esophagitis	20 mg twice a day (morning and evening). In severe pathology, you can increase the dose to 40 mg twice a day	Apply within 6 weeks
Zollinger-Ellison syndrome	The initial dose is 40 mg, taken every 6 hours. The dose can be maximized up to 480 mg per day.	Apply until the condition is completely normalized
Prevention of gastric reflux during surgery under general anesthesia	40 mg 1 - 2 hours before the start of the operation	Take in the morning of the day of surgery or just the day before

In case of serious kidney pathology with severe dysfunction, in which CC is less than 30 ml / min, and the concentration of creatinine in the blood is more than 300 g / l, it is necessary to reduce the daily dose of Kvamatel to 20 mg. If a person with such renal pathology needs to receive a large dose of the drug during the day, then the interval between doses should be increased to 36 - 48 hours.

Kvamatel ampoules

The ampoules contain dried powder, which is dissolved in physiological solution immediately before use. The resulting solution is used for intravenous administration in the form of injections or droppers. You should know that intravenous use of Kvamatel should be used only as a last resort, when it is not possible to take the drug in tablets.

Intravenous administration of the drug is carried out exclusively in a hospital, under the supervision medical staff... As soon as it becomes possible, it is necessary to cancel Kvamatel's injections and switch to taking pills.

The average dosage of Kvamatel intravenously is 20 mg (1 ampoule) twice a day. The drug should be administered strictly at intervals of 12 hours, for example, at 8.00 (in the morning) and at 20.00 (in the evening). The maximum allowable dose for intravenous administration at a time is 20 mg.

For the treatment of Zollinger-Ellison syndrome, the initial dose is 20 mg (1 ampoule). The drug is administered every 6 hours, and the dose is reduced depending on the acidity of the gastric juice and the person's condition.

In order to prevent the reflux of gastric contents into the esophagus during surgery under general anesthesia (Mendelssohn's syndrome), immediately before surgical intervention 20 mg (1 ampoule) of Kvamatel is administered intravenously. It is allowed to administer the drug in advance, but not later than 2 hours before the operation.

rules intravenous use Kvamatela. To inject Kvamatel intravenously, you need to know the rules for preparing the solution. Each ampoule of powder in the package comes with a bottle of sterile solvent. This solvent is designed for only one ampoule of powder. So, you need to dissolve the powder as follows:
1. Open the ampoule with solvent.
2. Take a syringe with a volume of at least 5 ml and draw up the solvent into it.
3. Pierce the rubber cap of the powder bottle and squeeze all the solvent out of the syringe.
4. Stir gently until a homogeneous solution is obtained.
5. Draw up the resulting solution into a syringe.

To dissolve the powder from one ampoule, you need 5-10 ml of solvent. The ready-made solution can be used within 24 hours.

If Kvamatel is administered as an intravenous injection, then the entire volume of the resulting solution from one ampoule is drawn into one syringe. A needle for intravenous injection is put on the syringe, and the drug is injected slowly, not less than 2 minutes.

For a dropper with Kvamatel, the resulting solution from one ampoule of powder is poured into an infusion solution. As an infusion solution, dextrose with potassium chloride or sodium lactate, isodexa, Ringer, Ringer lactate, Salsol A. Kvamatel is prepared for a dropper immediately before use. The duration of the infusion of Kvamatel is 15 - 30 minutes.

Kvamatel mini

Tablets with a low content of the active ingredient 10 mg are specially designed to eliminate the painful symptoms of increased acidity of gastric juice, such as heartburn, sour belching, etc. It should be remembered that smoking significantly reduces the effectiveness of the drug.

If symptoms of high acidity appear (heartburn, belching), you need to take one tablet of Kvamatel mini. A maximum of two tablets are allowed per day. The tablet should be swallowed whole, without chewing, but with a little water.

Kvamatel mini is used until the symptoms of increased gastric acidity are completely eliminated. However, the maximum allowable duration of the course of therapy is 2 weeks. If, after two weeks, the acidity of the gastric juice has not returned to normal and the pathological symptoms have not disappeared, you must stop taking Kvamatel mini and consult a doctor.

In domestic clinical practice, Kvamatel is used for the treatment of gastric ulcer and duodenal ulcer in children from 7 years of age. And although the manufacturers of the drug believe that it can be used only from the age of 16, use in pediatric wards under the supervision of medical personnel seems to be quite justified, expedient and as safe as possible.

In children, one of the most important factors in the development of diseases digestive tract - This is the increased acidity of gastric juice. That is why the leading method of therapy for many pathological conditions of the gastrointestinal tract in children is the method of reducing the secretion of hydrochloric acid. Among all drugs that reduce the secretion of hydrochloric acid, Kvamatel stands out, which has an excellent effect in minimal doses. That is why this drug was chosen for use in children. Next-generation drugs - for example, Nizatidine and Roxatidine, do not have significant advantages over Kvamatel, but are much more expensive.

To date, doctors consider the presence of the following pathological conditions as indications for prescribing Kvamatel to children:

• peptic ulcer of the stomach and duodenum;
• gastroesophageal reflux disease, accompanied by esophagitis of 2 - 3 degrees;
• zollinger-Ellison syndrome;
• stomach and intestinal bleeding.

Quamatel is justified for use in children for several reasons. Firstly, this is a powerful effect of suppressing the secretion of hydrochloric acid, which lasts for a considerable time, and is similar in strength to the action of proton pump inhibitors (Omez). However, proton pump inhibitors cannot be used in children strictly under 12 years of age. Secondly, Kvamatel has a protective effect on the mucous membrane of the stomach and esophagus, enhancing the restoration of the epithelium, neutralizing free radicals and activating the production of mucus.

Kvamatel is used in children in the composition complex therapy as an antisecretory agent that inhibits the production of hydrochloric acid. In this case, the dosage is calculated by the child's body weight: 2 mg per 1 kg of body weight. Thus, a daily dose is obtained, which is divided in half into two doses - in the morning at 8.00 and in the evening at 20.00. However, the maximum daily dose for a child should not exceed 40 mg.

With the development of bleeding or bleeding ulcers in a child, Kvamatel is used in the form of intravenous injections. The dosage is also calculated by weight: 2 mg per 1 kg per day. The calculated daily dose is also halved and administered twice a day, with an interval of 12 hours. The maximum daily dose of the drug for intravenous administration should also not exceed 40 mg.

Kvamatel for pancreatitis - how to take

Treatment of acute pancreatitis should be comprehensive. One of the good approaches for the treatment of pancreatitis is to suppress gastric secretion, which can reduce the activity of the pancreas and create functional rest for it. To achieve this goal, drugs from the group of H2-histamine blockers are used. Moreover, the third generation drug, Kvamatel, has optimal properties and minimal side effects. Against the background of the use of relatively low dosages of this drug, there is an effective suppression of pancreatic secretion, which is necessary for its restoration and termination inflammatory process in the organ.

Children and adults with severe pancreatitis receive Kvamatel by intravenous injection or infusion. If the disease proceeds in a relatively mild formthen tablets are used. In general, if there is no vomiting and nausea, you should take Kvamatel tablets. And only if it is impossible to take pills (nausea, vomiting, etc.), it is necessary to resort to the introduction of Kvamatel in the form of intravenous injections.

The dosage for children is calculated by body weight: 2 mg of Kvamatel per 1 kg of body weight, but not more than 40 mg. The resulting value is the daily dosage, which is divided into two equal parts and administered twice a day, morning and evening. It is optimal to administer the drug at intervals of 12 hours - for example, in the morning at 8.00 am and in the evening at 20.00. For adults, the dosage is 20-60 mg twice a day, also in the morning and evening. The dose is determined by the severity of the course of pancreatitis. That is, the more severe the pathology, the greater the dose of the drug a person should receive.

Intravenous administration of the drug allows you to eliminate pain syndrome within 2 days, and the normalization of alpha-amylase activity is observed on the 5-7th day. When Kvamatel tablets were taken, the pain syndrome was stopped on the third day, and the alpha-amylase activity returned to normal on the 3rd - 5th day of treatment. Digestive disorders are eliminated on the 3rd - 4th day of using the drug.

However, both children and adults should take Kvamatel for the treatment of acute pancreatitis for at least 2 weeks, despite the disappearance clinical symptoms diseases. Studies have shown that a two-week course of the drug leads to the normalization of the size of the pancreas.

After two weeks of taking Kvamatel in therapeutic doses, it is necessary to halve it, and use it for another 7 days. After that, you can completely cancel the treatment. This additional week of using the drug at half dosages is necessary in order to avoid the development of withdrawal syndrome.

Thus, Kvamatel is an effective drug that can form the basis for the treatment of pancreatitis in children and adults.

Side effects

Quamatel acts on histamine receptors quite selectively, however, blocking these structures in other organs leads to the development of side effects. The side effects of all forms of the drug - Kvamatel tablets, Kvamatel ampoules and Kvamatel mini - are exactly the same. Everything possible symptoms from various organs and systems, which are regarded as side effects of Kvamatel, are reflected in the table:

The organ system from which the side effects	Side effects
Digestive tract	Dry mouth
	Change in taste
	Nausea
	Vomiting
	Abdominal pain

Kvamatel - effective drug for the treatment of pathologies of the upper gastrointestinal tract. The clinical effect is to reduce the concentration and amount of gastric juice, to regulate the synthesis of pepsin.

The drug selectively blocks histamine H2 receptors. Reduces basal and stimulated gastric acid production, the concentration of hydrochloric acid and pepsin. Explicit therapeutic action Kvamatel starts after 1 hour and lasts for 10-12 hours.

Additionally, Kvamatel increases the formation of gastric mucus and the content of glycoproteins in it, which enhances the protection of the stomach from irritants. Increases the production of bicarbonate and endogenous synthesis of prostaglandins, accelerates the tightening of damage to the gastric mucosa, incl. scarring of ulcerative lesions and stopping gastrointestinal bleeding.

Without significantly affecting gastrin indicators after meals or on an empty stomach, Kvamatel does not "inhibit" gastric motility, exocrine pancreatic activity, blood supply in the portal system, hormone levels, and has no antiandrogenic effect.

The half-life of the active substance of the drug is approximately 3 hours. The main part is excreted from the body unchanged in the urine.
The use of Kvamatel for heartburn and gastralgia (provoked by increased acidity of gastric juice) has received many positive reviews from doctors and patients, but this is not the only prescription for the medicine.

When acute pancreatitis and exacerbation of chronic pancreatitis, urgent therapy often begins with intravenous drip of Kvamatel, and after the patient's condition improves, they switch to taking pills.

Indications for use of Kvamatel

1. Peptic ulcer and 12 duodenal ulcer;
2. Functional dyspepsia associated with increased gastric secretory function;
3. Erosive gastroduodenitis;
4. Reflux esophagitis;
5. Prevention of recurrent bleeding from the upper gastrointestinal tract (GIT);
6. Zollinger-Ellison syndrome;
7. Prevention of gastric juice aspiration in patients undergoing surgery under general anesthesia (Mendelssohn's syndrome);
8. Bleeding from the upper gastrointestinal tract (as part of complex treatment).

Instructions for use of Kvamatel, dosages

Instructions for use of the drug contain detailed guidance on how to use Kvamatel for treatment and dosage determination.

Kvamatel tablets - instructions for use

For gastric ulcer and duodenal ulcer in the acute phase, the dosage of Kvamatel is 40 mg 1 time / day before bedtime or 20 mg 2 times / day, morning and evening.

According to diagnostic data, if necessary, the daily dose is increased to 80-160 mg. The duration of the course of therapy is on average 4-8 weeks.

For the prevention of exacerbations of gastric and duodenal ulcers, the drug is prescribed at a dosage of 20 mg 1 time / day before bedtime.

With Reflux-Esophagitis, the dosage of Kvamatel is 20 mg 2 times / day for a course of 6 weeks, it is possible to increase the dosage to 40 mg.

With Zollinger-Ellison syndrome therapeutic dose - 20-40 mg. Every 6 hours. The dosage depends on the patient's condition. The duration of treatment is determined by the doctor.

To prevent the ingress of gastric juice into airways with general anesthesia - dosage of Kvamatel 40 mg the day before the operation.

Kvamatel in ampoules - instructions for use

Kvamatel is used in / in, jet or drip only in severe cases or when it is impossible to take the drug inside.

Kvamatel in ampoules is used exclusively in a hospital under constant supervision. As the patient's data improves, it is recommended to switch to oral administration (in tablets). The standard dosage is 20 mg 2 times / day (every 12 hours). A single dose should not exceed 20 mg.

For the treatment of Zollinger-Ellison syndrome, the initial dosage is 20 mg every 6 hours, according to symptoms and diagnostic data, the dosage is adjusted depending on the secretion of hydrochloric acid and the patient's condition.

To prevent the penetration of gastric juice into the respiratory tract under general anesthesia - a dosage of 20 mg Kvamatel intravenously the day before the operation.

Preparation of solution for injection

Injections are used exclusively in a hospital and, as soon as possible, the patient is transferred to oral administration of Kvamatel (tablets).

For the introduction of Kvamatel intravenously drip - dissolve the contents of the ampoule in 100 ml of 5% glucose solution for infusion and slowly inject over 15-30 minutes.

The prepared solution can be stored at room temperature for 24 hours.

Features:

Against the background of kidney or liver dysfunction, the daily dose is reduced to 20 mg.

The maximum single dose of Kvamatel is 20 mg.

Application of Kvamatel in higher doses can cause symptoms of overdose, on the basis of signs of manifestation comparable to side effects.
Treatment with Kvamatel is stopped smoothly, gradually reducing the dose to avoid withdrawal syndrome

Contraindications Kvamatel

Instructions for use Kvamatel highlights a list of contraindications for use:

• hypersensitivity to famotidine and other blockers of histamine H2-receptors;
• pregnancy and / or lactation;
• childhood.

Care should be taken to prescribe Kvamatel for renal and hepatic insufficiency, with cirrhosis of the liver with a history of portosystemic encephalopathy.

Side effect of Kvamatel

• dry mouth, vomiting, abdominal pain, constipation, diarrhea, decreased appetite;
• hepatocellular, cholestatic or mixed hepatitis, acute pancreatitis;
• pancytopenia, leukopenia, thrombocytopenia, bone marrow hypo- or aplasia;
• urticaria, skin rash, dry skin, itching, bronchospasm, angioedema, anaphylactic shock;
• arrhythmia, bradycardia, AV blockade, lowering blood pressure;
• headache, dizziness, drowsiness, confusion;
• decreased visual acuity, tinnitus;
• at higher dosages - hyperprolactinemia, gynecomastia, amenorrhea, decreased libido;
• myalgia, arthralgia, fever.

Analogs of Kvamatel, list

Analogs of the drug include (list of drugs):

• Famosan,
• Famotidine,
• Famotidine-Acri,
• Ulfamid,
• Gastrosidine,
• Famonite.

It is important to understand that analogs are not a complete copy of the drug - instructions for the use of Kvamatel, price and reviews for analogs do not apply and cannot be used as a guide (instruction) in prescribing treatment or dosages. When replacing Kvamatel, it is important to consult a specialist.

Terms and conditions of storage
The tablets should be stored at a temperature not exceeding 30 ° C, the lyophilisate - 15-25 ° C, in a dark place out of the reach of children.

Shelf life:
Tablets and solvent - 5 years; Lyophilisate - 3 years.

In one vial of the drug in the form of a lyophilized powder, from which injection, contains the main substance - famotidine 20mg. The auxiliary component is a solution sodium chloride 0.9% in 5ml ampoule.

Composition of one coated tablets also includes 20 mg of the main substance famotidine and auxiliary components, for example, lactose monohydrate.

Release form

The medicine is available in the form of a coated pills, placed 14 pieces in each blister, 1-2 blisters per pack.

Also proposed Kvamatel Mini, 14 tablets in one blister per pack.

In addition, the drug is sold in the form lyophilized powder, from which the injection solution is prepared. The product is placed in bottles, which are additionally accompanied by ampoules with a solvent - 5 pieces of each substance in a package.

pharmachologic effect

The drug Kvamatel has an antiulcer effect.

Pharmacodynamics and pharmacokinetics

This drug, acting on the walls of the stomach, helps to effectively reduce the production of gastric juice, reducing its volume. This does not change the evacuation function of the stomach, blood circulation in the liver, secretory function of the pancreas, and so on.

Dosage form Kvamatel Mini also used for the treatment of ulcerative lesions of the stomach and duodenum. The main indication for taking pills is ... This not only eliminates unpleasant symptoms, but also prevents excessive production of hydrochloric acid. therefore Kvamatel Mini helps to eliminate heartburn and does not allow the development of peptic ulcer disease.

To achieve a therapeutic effect lasting 10-12 hours, a single dose of the drug at a dosage of 20-40 mg may be sufficient. If you take 10 mg, then its effect will last for about 9 hours. The drug is absorbed in the gastrointestinal tract, metabolized in the liver, excreted by the kidneys, a small part in the form of metabolites, and mostly unchanged.

Indications for Kvamatel's use

• during an exacerbation, to prevent relapse;
• erosive gastroduodenitis;
• treatment and prevention of various lesions of GI, uncomplicated forms of disease development.

Contraindications for use

• , ;
• childhood;
• intolerance to the drug and other blockers of histamine H2-receptors.

Special care is required for the treatment of patients with Kvamatel renal or liver failure accompanied by portosystemic encephalopathy .

Side effects

Treatment with Kvamatel can lead to the development of various undesirable reactions in the body's activity. Especially often there are deviations in the functions of the digestive tract: nausea , vomiting stool problems loss of appetite , liver dysfunction , dry mouth.

Often suffers from nervous, hematopoietic and the cardiovascular system, which is manifested by: headache, high fatigue, anxiety, heart rhythm disturbances, leukopenia , thrombocytopenia and so on. Can also develop allergic reactions, body temperature rise, muscle or joint pain occur, gynecomastia and other. When any unwanted effects you need to contact a specialist.

Kvamatel, application instruction (Way and dosage)

Despite the fact that the indications for the use of Kvamatel include various diseases Gastrointestinal tract associated with ulcerative lesions, starting treatment should be excluded malignancy of the ulcer .

Solution for injection, prepared from lyophilized powder, is used strictly for intravenous administration in a hospital setting. The medicine is prepared from a powder in a vial, mixing with a solvent from an ampoule. When the powder is completely dissolved, the agent is slowly injected into the vein - within 2 minutes.

In addition, intravenous infusion of Kvamatel is possible. For this, the powder is dissolved in 5 ml of sodium chloride 0.9% and mixed with an infusion solution. The period of this type of administration can be 15-30 minutes.

The drug in tablets should be taken without crushing or chewing, drinking plenty of liquid. The dosage and duration of therapy is set by the attending physician for each patient.

This also applies to pills. Kvamatel Mini... However, in most cases, adult patients suffering from acid-induced heartburn should take 1 tablet daily. To prevent heartburn and postprandial symptoms, one tablet is also prescribed one hour before meals. No more than 2 tablets are allowed per day.

Continuous treatment should not exceed a course of 2 weeks. If, after 7 days of therapy, the symptoms do not disappear, you need to urgently visit the attending physician - undergo a second examination and receive a new treatment appointment.

Overdose

Although cases of overdose do not lead to the development of severe deviations in health or well-being, patients should comply with the prescribed dosage. Overdose treatment includes gastric lavage and conducting the necessary symptomatic therapy.

Interaction

Quamatel has no effect on biotransformation funds , which related to the system cytochrome P450 .

Concomitant use with can reduce its absorption by changing the pH formula of gastric juice.

A decrease in the absorption of famotidine was noted when the drug was combined with antacid drugs .

The combined reception with drugs with reduces excretion famotidine .

Terms of sale

The drug is available in pharmacies with a prescription.

Storage conditions

Each form of the drug must be stored in a dry and dark place, at 15-25 degrees.

Shelf life

The drug in pills can be stored for 5 years.

Powder for cooking injection solution - 3 years.

Kvamatel Mini no more than 2 years.

Kvamatel's analogs

Matching ATX level 4:

Drugs with a similar effect include:

• Gasterogen;
• Famotel;
• Pepsidin;
• Famosan;

Alcohol and Kvamatel

Instructions for the use of Kvamatel mini and other forms of the drug do not contain information on the admissibility of drinking alcohol during treatment. But since exactly alcoholic drinks among other factors, they have an irritating effect on the digestive tract, then alcohol must be abandoned.

Reviews about Kvamatel

Numerous reviews of Kvamatel confirm its effectiveness, since as a result of treatment: pain disappears, the activity of the digestive system improves, and so on. At the same time, some users are interested in why tablets Kvamatel help best and what form to use for severe disabilities. In response, experts advise to visit a gastroenterologist and find out everything after the examination.

However, there are reports when patients say that treatment with Kvamatel did not help them. Moreover, additional problems appeared in the work of the digestive tract.

Kvamatel's price where to buy

In pharmacies in Moscow and some Russian cities, the price of Kvamatel varies between 119-450 rubles.

In Ukraine, this drug can be purchased in various forms at a cost of 39-179 UAH.

• Online pharmacies in RussiaRussia
• Online pharmacies of UkraineUkraine
• Internet pharmacies in KazakhstanKazakhstan

ZdravCity

Kvamatel tab. p.p. 20mg n28Gedeon Richp OJSC

Kvamatel tab. p.p. 40mg n14Gedeon Richp OJSC

Kvamatel lyof. i / v 20mg n5 (with Na chloride solution 0.9% solution 5ml)Gedeon Richp OJSC

Diseases of the gastrointestinal system are common in our life. If such ailments are not treated in time, an ulcer may appear. For the treatment of exacerbation in such diseases, the drug "Kvamatel" is often prescribed. It works quickly, has a cumulative effect and is inexpensive. Analogues cannot always replace it. For example, when using a substitute called Famotidine, people complain of side effects.

Composition of the medicinal product

Medicine has two forms of release. It is a lyophilized powder that is specially diluted for injection, and tablets.

The preparation for injections "Kvamatel" (20 mg) (instructions for use describe in detail the scheme for using this medication) contains the active ingredient famotidine. Auxiliary elements here are:

• aspartic acid;
• mannitol;
• sodium chloride;
• purified water.

One tablet contains 40 mg of the active ingredient. Here the additional substances are:

• colloidal silicon dioxide;
• magnesium stearate;
• povidone K90;
• sodium carboxymethyl starch;
• talc;
• corn starch;
• lactose monohydrate.

Powder for solution preparation is enclosed in glass ampoules. The package contains five ampoules and a solvent for them. The tablets are round and pink in color. Packed in aluminum blisters. There can be 14 or 28 tablets in a cardboard box.

The drug "Kvamatel": indications for use

The indication for the use of the medication is an ulcer of the duodenum and stomach, which is in the stage of exacerbation. Prescribe a medicine for symptomatic ulcers and to prevent their formation. It is used for reflux esophagitis, as well as for gastrinoma, the drug "Kvamatel". The use of the drug gives good result with gastric and intestinal bleeding, where it is used in combination with other medicines. Prescribe a remedy for and also for the prevention of gastric aspiration, which is carried out under general anesthesia

Contraindications

The drug "Kvamatel" acts quickly and effectively in exacerbating gastrointestinal diseases. Application (reviews note that this remedy has few contraindications and is convenient to use) this medication should be carried out only as directed by a doctor. The medication is not prescribed during pregnancy and during breastfeeding child. Childhood and hypersensitivity to the constituent substances of "Kvamatela" serve as a ban on the use of the drug. Also, the drug is not used with special sensitivity to other drugs that are blockers of histamine H2-receptors.

With extreme caution, the drug is prescribed to patients with hepatic and renal failure, as well as with cirrhosis of the hepatic organ, which is accompanied by a history of portosystemic encephalopathy.

Medicine "Kvamatel": instructions for use

Ampoules and tablets "Kvamatel" should be used only after consulting a doctor.

The lyophilized powder used for the preparation of an injection solution is administered:

• intravenously;
• drip;
• jet.

This treatment regimen is used only in severe cases, when the patient is unable to take the drug orally.

This form of release is used only in a hospital. If possible, the patient is immediately transferred to tablets. The average injection dosage is 20 mg (one ampoule), it is injected twice a day, that is, every twelve hours. More than 20 mg should not be administered at a time.

If gastrinoma is present, treatment begins with a dose of 20 mg, which should be administered to the patient every six hours. With subsequent treatment, the dose is adjusted, which is affected by the patient's condition and the production of hydrochloric acid by the stomach.

To prevent gastric aspiration before use general anesthesia about 20 mg of the drug is injected into a vein. As a rule, this procedure is carried out the day before surgery or two hours or more before it takes place.

Patients with kidney pathology (when CC falls below 30 ml / min, and the serum plasma index exceeds 3 mg / dL), the daily dosage is reduced to 20 mg. The interval between taking the medicine is increased to 36-48 hours.

If there are abnormalities in the liver, then "Kvamatel" (20 mg) instructions for use advise to use with extreme caution. In this case, the drug is administered in small doses.

Notes that before injection, you should properly prepare a solution with the medicine "Kvamatel", instructions for use. The ampoule with powder is dissolved in 5-10 ml of solvent. The prepared solution at room temperature does not change its properties throughout the day. The medicine is administered slowly, for at least two minutes. With the introduction of the drug by drip, the duration of the infusion is 15-30 minutes. In this case, the solution is made immediately before the procedure.

At the first opportunity, the patient is switched from injections to tablets.

For stomach ulcers and duodenal ulcers, which are in the acute stage, the drug is prescribed in an amount of 40 mg. This amount is used once a day. You can drink the medicine twice a day, 20 mg. If necessary, the daily dosage is adjusted to 80-160 mg. The duration of the therapeutic course is from four to eight weeks.

To prevent exacerbation of ulcers of the gastric organ and duodenal ulcer, "Kvamatel" is consumed at 20 mg before going to bed.

When diagnosed with reflux esophagitis, tablets are drunk at 20 mg in the morning and evening. The treatment is carried out for six weeks. If necessary, the dosage is increased to 80 mg and divided into two doses.

In patients with gastrinoma, the initial dose is 20-40 mg. This amount of medication should be taken every six hours. If there is evidence, then the daily rate is increased to 240-480 mg. The duration of treatment depends on the patient's state of health.

To prevent the release of gastric contents during the period of general anesthesia, tablets are used in an amount of 40 mg. The drug can be used the day before the surgery or on the day of the procedure.

Reviews of patients and doctors

Notes that doctors prescribe the drug "Kvamatel", instructions for use to prevent exacerbation of ulcers and gastritis. Ampoules (reviews indicate the affordable cost of the drug, about 120 rubles for 14 pieces) can be removed severe symptoms diseases, but you should not use them for a long time, and with improvement, it is better to immediately switch to pills.

Many patients are satisfied with the result that the medicine gives. They note that after the first application, a therapeutic effect is noticeable. The pain stops, the aggressiveness of gastric juice decreases. Acid eructation and heartburn pass. The drug is usually well tolerated by patients and rarely causes negative effects.

For some people, Kvamatel did not help. According to them, the pain, heartburn, and not only did not go away, but also worsened. These patients were forced to look for a more suitable medicine. In some cases, the drug has caused side effects such as headache, nausea, diarrhea, confusion, and difficulty concentrating. There are patients in whom withdrawal of the drug was accompanied by negative symptoms, nausea, and intestinal upset.

The drug "Kvamatel" received good reviews from doctors. They say it is effective remedy with exacerbation of gastric ulcer and duodenal ulcer, as well as gastritis. They note that the medicine is suitable for many patients, quickly relieves pain and discomfort in the gastrointestinal tract. This medication is often prescribed for increased acidity of the stomach, heartburn and in the presence of a tendency to form gastritis. This tool is often used in combination with other medicines.

Drug analogues

Despite the proven effectiveness of the drug, there are people who have not been approached by Kvamatel. Instruction (analogs of this medicine can always be found in a pharmacy, but only a doctor should select them) recommends that if adverse reactions appear, immediately interrupt therapy with this drug and review the treatment. Most often, "Kvamatel" is replaced by the following means:

• "Gistak";
• "Gastrosidin";
• "Zantak";
• "Pepsidin";
• "Ulfamid"
• "Atsilok";
• "Gasterogen";
• Famopsin;
• Famosan;
• Famotel;
• "De-nol".

These and other drugs are good alternatives to Kvamatel. Analogues cheaper than this remedy can be found in a pharmacy, these are: "Famotidine", "Ranitidine", "Ranisan", "Omez", "Ortanol", "Omeprazole". There are many substitutes for "Kvamatel" on the market, and in order not to get lost in this variety of medicines, you should consult a doctor.

Kvamatel tablets - radar, which is used in gastroenterology. It is not possible to purchase it yourself. To purchase, the patient must obtain a prescription from a doctor, and also read the instructions before use.

Insert sheet

The drug Kvamatel is prescribed to the patient in different forms: pills and lyophilisate for injection. A medical prescription necessarily indicates which form of release is necessary for the consumer:

• tablets Kvamatel MINI - contain 10 mg of active ingredient;
• Kvamatel 20 (tablets) - contains 20 mg of the active ingredient;
• Kvamatel 40 - contain, respectively, 40 mg of the drug;
• Ampoules Kvamatel - 20 mg in each vial.

The active substance of the drug is famotidine. It helps block histamine receptors located on the surface of the gastric and intestinal mucosa. Thus, the drug Kvamatel reduces the release of hydrochloric acid, which disrupts digestion and damages the walls of the gastric tract. The generic drug famotidine also reduces the negative effects of pepsin.

The medication is also prescribed because it does not affect gastric motility. The natural work of the stomach allows food to move into the intestines in time. Treatment helps to reduce acidity, while at the same time does not affect the enzymes of the pancreas, liver and human hormones.

Indications and contraindications

A guide to using Kvamatel should be obtained from a specialist. After the examination, the doctor will select an individual dosage for the patient and tell you about the features of the drug. Each potential consumer needs to study the package insert that is attached to the Kvamatel product. The instructions for use describe the following indications for use:

• ulcerative lesions of the stomach or intestines (in acute stage), prevention;
• erosive gastroduodenitis;
• reflux;
• zollinger-Ellison or Mendelssohn syndromes;
• prevention of bleeding from the upper digestive system;
• dyspeptic disorders resulting from increased acidity.

The person taking the medicine should be well examined. Doctors do not prescribe drugs in this group to the following patients:

• having increased sensitivity or allergy to the components of the medication;
• women throughout gestation and lactation;
• children of all ages.

Patients with liver and kidney pathologies need to be given special attention and better monitor their body's response to the use of tablets or the administration of a solution.

Using

International name of the drug (famotidine) prescribed in the instructions for latin, has its own application features:

1. before using it, it is better to undergo a complete examination, since pharmacy remedy capable of giving oiled clinical picture many dangerous diseases;
2. it is unacceptable to abruptly cancel the medication - it is necessary to take smaller doses, and then stop using it altogether;
3. it is unacceptable to combine famotidine with antifungal drugs and antacids, you need to take a break for at least 2 hours;
4. during the period of treatment, you must follow a diet;
5. in case of liver and kidney pathologies, the volume of the prescribed medication should be reduced.

Tablets

Kvamatel tablets instructions for use recommend drinking 1 to 4 times a day. The volume and frequency of consumption of famotidine depends on the severity and nature of the pathology. It is advisable to select an individual treatment regimen for each patient.

Table of generally accepted schemes for using tablets.

Disease	The amount of the drug	Duration of admission
Aggravated ulcer	40 mg in the evening as a single dose or 20 mg 2 times with the same break; maximum volume - 160 mg	1 to 2 months
Ulcer prevention	20 mg before bedtime	Not more than a month
Esophagitis reflux	20 mg in the morning and evening (sometimes double-volume tablets are acceptable)	For 6 weeks
Zollinger-Ellison syndrome	40 mg up to 4 applications per day; maximum dose 480 mg	As predicted
Prevention of Mendelssohn's syndrome	40 mg before anesthesia (over 1 or 2 hours)	Once
Dyspeptic disorders caused by acidity	10 mg 1-2 times a day; maximum dose per day 20 mg	No longer than 14 days

Important! The drug can affect the speed of psychomotor reactions, therefore, during the period of administration, be careful not to exceed the dose prescribed by the doctor.

Injections

Kvamatel is administered intravenously in exceptional cases when it is impossible to hesitate and there is no opportunity to take pills. Intramuscular injection unacceptable. The ampoules contain powder white... Prepare a solution before use. For this, sodium chloride is used (up to 10 ml).

It is unacceptable to interfere with a solution of lidocaine, novocaine or other liquids for injection. It is preferable to inject the medication by drip, but injections into the vein are allowed. The solution is introduced slowly, at least 2 minutes. Depending on the severity of the pathology, doctors choose a certain dose of famotidine:

• 20 mg is used once to prevent Mendelssohn's syndrome (not earlier than 2 hours before surgery);
• 20 mg 1-2 times injected with exacerbated manifestations of an ulcer (the break should be exactly 8 hours);
• 20 mg quadruple dose for the treatment of Zollinger-Ellison syndrome.

Solution for injection helps in critical situations when emergency intervention in the digestive tract is needed. Subsequently, the patient is transferred to oral administration drug.

Important! Injections are used exclusively in medical institutions, staging an injection on your own is unacceptable.

Unpleasant reactions

For the medicine Kvamatel, the use must strictly correspond to the medical prescription. You can not independently adjust the dose of the medication or change the regimen. It should be remembered that, like any analogue of Kvamatel, the declared agent has a chance to cause side effects:

• vascular disorders - bradycardia, arrhythmia, pressure surges;
• digestive abnormalities - decreased appetite, abdominal pain, liver pathologies;
• neurological manifestations - apathy, fatigue, drowsiness;
• disturbances in the work of the hematopoietic system;
• allergic and dermatological side effects;
• fever, muscle pain, hearing impairment.

When unpleasant reactions appear, the patient needs to get medical assistance... After elimination negative effects the specialist selects suitable analogs and substitutes that will not provoke such a reaction.

Analogs and generics

The drug Kvamatel has structural and relative analogs. The former completely replace the drug, since they contain the same active ingredient. Relative analogs have similar indications to use, but work on the basis of another active ingredient.

Structural substitutes:

• Famotidine;
• Gastrosidine;
• Famosan;
• Ulfamid.

If, for some reason, the Kvamatel product is not suitable for the consumer, the analogue is selected with another active ingredient:

• Ranitidine;
• Zantak;
• Histak;
• Cimetidine.

Conclusion

The prescription product Kvamatel adverse reactions rarely occur, but they are not excluded. In order for the treatment to bring maximum benefit, it is necessary to undergo an examination and get an appointment from a specialist before using the drug.

Using pills and injections on your own is dangerous and can lead to unexpected body reactions. With absence positive effect consult a gastroenterologist within a few days of using the tablets.