How to properly use the drug Clotrimazole from the thrush? Clotrimazole: Treatment of thrush Clotrimazole Instructions for use from what.

Almost every person faces such a problem as thrush. It arises suddenly, as if it would be nowhere else and brings a lot of trouble, causing harm to health. Clotrimazole will help get rid of this disease.

What thrustle is

What is thrush? This is a fungal disease caused by special conditionally pathogenic microorganisms by candidates who live even in a healthy microflora of the human mucosa. The disease begins when the colony of yeast-like fungi begins to grow sharply.

Such a phenomenon is associated with a violation of the protective properties of the body. Often because of a long disease, against the background of a long antibiotic reception and / or hormonal drugs or due to the length of the long-lasting person in the extreme for him stressful situations. Influence the occurrence of thrush (in other words - vaginal candidiasis) can:

• chronic diseases;
• metabolic diseases;
• allergy;
• pregnancy;
• non-compliance with personal hygiene;
• hard diets;
• immunodeficiency;
• oncology;
• frequent I. long use tampons;
• wearing synthetic fitting underwear;
• chemotherapy course.

As a result, the natural balance is disturbed, and the candidate fungus begins to grow, damaging mucous membranes and skin cover.

The thrush is not considered a dangerous disease, but in the absence of proper treatment, it can show itself as a catalyst for quite serious health problems.

About thrush (candidiasis): video

Clotrimazole efficiency in the fight against thrush

Vaginal candidiasis requires integrated treatment: local and internal. It is timely therapeutic actions Assist to avoid serious complications.

Often in the treatment of thrush in women, men and children use such a universal exterior tool as Clotrimazole. This is a simple, but effective drug, effective in therapy not only of the candidiasis, but also killing a number of pathogens, such as staphylococci, streptococci. It eliminates the symptoms accompanying the disease:

• white curls;
• female;
• soreness;
• hyperemia.

Quick Results should not be expected, however, adhering to clear instructions of the attending physician, you can achieve full cure. In this case, the cost of the drug is small. A combination of several forms of Clotrimazole will speed up recovery.

The effectiveness of the drug is based on the effects of the active substance for ergosterol, which is part of the fungal membrane. It makes losing their nutrients, which ultimately leads to death. Clotrimazole affects those microorganisms that are growing by division. It destroys cells and controversy Candid, paralyzing their livelihoods.

Minimum doses, irregular use leads only to blocking the spread of the arousa of the thrush. The complete extermination of causative agents of the disease is possible only with an integrated approach, high doses and compliance with the recommendations of the doctor.

Composition and form of release

Clotrimazole relates to antifungal and synthetic antibacterial agents. Active component - 1 - [(2-chlorophenyl) diphenyl methyl] -1n-imidazole (C22H17CLN2). This is a white crystalline substance that does not have smell and insoluble in water.

Medicaseous drug Clotrimazole is produced by different pharmaceutical companies around the world. There are several forms of this. drug:

• vaginal candles;
• vaginal pills;
• cream;
• solution;
• gel.

All these types of Clotrimazole are used externally or intravaginal (for women).

Clotrimazole form and their additional components

Since there is a wide variety of output forms, then composite parts (additional components) are different.

Cream

Cream Clotrimazole 1 and 2% is used in the treatment of thrush in men and women. His advantages:

The cream contains the following auxiliary components:

• liquid paraffin;
• ketosterl alcohol;
• white soft paraffin;
• ketomacrologol 1000;
• purified water;
• chlorokrezol;
• dinatari Edetat;
• lemon acid;
• two-axis sodium phosphate (anhydrous);
• propylene glycol;
• sodium metabisulfit.

Vaginal candles

The most common form of means for the treatment of thrush in women is suppositories (candles) vaginal. The feature of this type of Clotrimazole:

As part vaginal suppositoriesexcept active active substance, there are semi-synthetic glycerides (solid fats).

Gel for outdoor use

Gel - new form Clotrimazole. This is a homogeneous white substance for local application. Such a means quickly absorbed, slightly drying the amazed places.

As part of the gel:

• alcohol cetylovy;
• propylene glycol;
• glycerol;
• alcohol benzyl;
• cetomacherogol emulsion wax;
• carbomer 940;
• sodium hydroxide;
• chlorokrezol;
• purified water.

Liquid form of clotrimazole: solution

The solution relatively recently appeared on the pharmaceutical market, so it has not yet been widely used in the treatment of thrush. This is a transparent, slightly viscous liquid with an alcohol smell.

This means in the form of additional components present:

• benzyl alcohol;
• propylene glycol;
• 2-octyldodecanol;
• polyethylene glycol 400;
• sodium citrate;
• isopropyl alcohol;
• water.

Clotrimazole-acryin ointment

Often, the ointment is used for the treatment of thrush. The most popular Clotrimazole-Akrichin from the Russian manufacturer. This is an inexpensive means in the line of drugs of this species. The ointment quickly envelops the mucous membrane, soften the dry damaged places. Its efficiency is about 90%.

The auxiliary components of Mazi are:

• propylene glycol;
• polyethylene oxide 1500;
• polyethylene oxide 400;
• nipagin (methyl aprichedroxibenzoate).

Vaginal tablets

Recently, doctors often recommend using Clotrimazole in tablets for intravaginal use. Their advantage is the lack of a fat basis. However, the cost vaginal tablets slightly above the remaining pharmaceutical forms of clotrimazole.

Additional components of vaginal tablets are:

• lactose monohydrate;
• potato starch;
• adipic acid;
• sodium bicarbonate;
• magnesium stearate;
• silicon colloidal dioxide;
• sodium Laurilsulfate.

In many packages with such a medicine there is a special applicator for the introduction of the drug deep into the vagina.

Spray

Pictures the popularity of the spray of Clotrimazole. There are enough 1-2 injection to cover the entire outer surface of the genitals. Often it uses men in the treatment of thrush.

In its composition besides the active substance:

• isopropylmiristat;
• ethanol.

Restrictions and contraindications: Is it possible to use during pregnancy

Like all drugs, Clotrimazole has a number adverse Reactions and contraindications to use.

Contraindications

All forms of release of Clotrimazole cannot be used in the following cases:

Restrictions

It is necessary to use this tool with caution:

• during pregnancy for 2 and 3 trimester;
• during lactation;
• in the presence of chronic liver failure;
• if the age of the patient is above 60 years;
• amid the pathology of blood formation organs;
• during colds, accompanied by fever and increasing body temperature.

Adverse reactions

Typically, Clotrimazole is easily transferred to patients, without the occurrence of serious adverse reactions. It happens that when the recommended doses exceeds, negative reactions of the body arise.

May be observed:

• redness of the mucous;
• feeling of burning and tingling in places of application;
• hives;
• irritation;
• nausea, turning into vomiting;
• the appearance of eats;
• cystitis;
• peeling skin Pokrov;
• student urination;
• pain during sexual intercourse;
• headache;
• selection of genital organs.

Special conditions

There are special conditions when unwanted use of Clotrimazole:

• the use of some drugs: Nistatin and Natamicina;
• the use of other vaginal means;
• consumption of alcoholic beverages;
• unprotected sex.

The drug Clotrimazole and all its structural analogues, including Clotrimazole-Akrichin, are non-prescription. However, this does not mean that you can get involved in self-medication. Only a doctor after the diagnosis of thrush can register this tool.. The course of therapy does not exceed 4 weeks and depends on the dose of this medication. Regularity - at least 2 times a day.

If after the first week of use does not have an improvement, then you should contact the doctor for changing the drug.

How to apply women

Use cream, ointment, candles and vaginal clotrimazole tablets with women as follows:

1. Lyzha on his back, bending his legs in the knees and putting them on the parties, it is necessary to introduce the means in the vagina.
2. If there is a special applicator, then this manipulation can be carried out with it.
3. After the administration of the drug should be slightly lie down (at least 30 minutes).
4. So that the medicine does not leave stains on underwear, it is recommended to use daily gaskets, but in no case with tampons.
5. When using tablets, they must be pre-slightly twisted in warm water.

Often the doctor prescribes for the treatment of thrush at the same time several types of drug. In such cases, it is necessary to take into account the consistency of each form. Ointment and / or candles are appropriately used before bedtime, and cream, gel, solution and pills - in the morning and daytime.

How to use the means to men

Naturally, in men's therapy, men use such forms of clotrimazole as ointment, cream and solution. In order to prevent recurrence, the treatment of both partners is mandatory.

Unbearable completely disease can be the result of the development of dangerous pathologies, such as vesiculitis and prostatitis.

Despite the fact that the thrush is considered female diseaseFungi Candidates are capable of shortening immunity to take care of male genitals. Therefore, when the thrush is identified from the partner, mandatory treatment is required. As a rule, men's urologist appoints Clotrimazole twice a day. In this case, the ointment, the solution or cream is applied to the pure head of the penis.

Use for prevention

Clotrimazole does not apply as a prophylactic tool for suppressing a possible occurrence of fungal infection, but periodically used to renowning the birthway on the eve of the birth of a child.

Analogs of Clotrimazole in the treatment of thrush

If for some reason it is impossible to use this drug, then the doctor has the right to replace the drug with an analog that does not contain in its composition of Clotrimazole.

Analogs of the Preparation - Table

Name of the drug	Forms of release	Active substance	Indications for use	Contraindications	Side effects	Use during pregnancy	The average cost and manufacturers
	cream; powder; solution for outdoor use; spray.	bifonazole.	Candidiasis: nails; vagina; skin; diallos; dermatophytium.	hypersensitivity; chest age.	allergic reactions	carefully	spray - about 120 r.; powder - 30 r.; cream - up to 70 p. Manufacturer Synthesis OJSC (Russia)
	cream; vaginal suppositories; vaginal tablets.	okonazole.	candidiasis; deprived bison; seborrhea; erytrazm.		burning;		vaginal candles and tablets - up to 900 r.; cream - up to 400 p. Manufacturer TEVA Pharmaceutical Works Co. Ltd. (Hungary)
Pimafucin	vaginal candles; cream; tablets are intestine-soluble.	natamicin	various types of candidiasis; otomicosis; dermatomyque; otitis complicated by mushrooms.		nausea; diarrhea; light irritation; burning.	allowed	tablets - up to 500 r.; cream - within 350 r.; suppositories - up to 510 p. for 6 pcs.; tablets - about 450 p. Manufacturers: Temmler Italia S.R.L. (Italy); Astelllas Pharma CJSC (Russia).
Neo-penotran	vaginal suppositories	metronidazole; mikonazole.	vaginal candidiasis; trichomoniasis; inflammatory process of childbearing organs.				the average price is 900 p. Manufacturer EMBIL PHARMACEUTICAL CO. (Turkey)
Nystatin	outdoor ointment; vaginal suppositories; rectal candles; pills.	nystatin	diseases caused by fungi including candidiasis of different etiology	pancreatitis; renal and liver failure; stomach ulcer; Pimafucin is an analogue of Clotrimazole, not all microhal is suitable - one of best tools In the treatment of candidiasis Bifosin is rarely used in the treatment of vaginal candidiasis

Fungal diseases or myoses are caused various species fungi. Mushrooms cause such famous diseasesLike a deserid deprived, epidermofitius stop, trico, microsporia, candidiasis and many others.

Some types of fungi constantly live in the body and cause the disease only with the weakening of the body's protective forces. Such diseases include candidiasis or thrush.

A large propagation of fungal diseases occurs also because the patients traditionally do not give them great importance and are treated independently, without circulation to the doctor. And quite in vain: the fungus can cause complications:

• body allergization with further formation of allergic diseases (from skin diseases and cold to bronchial asthma);
• attachments of bacterial or viral infection;
• spreading fungus on internal organswhat can cause heavy general state.

What is Clotrimazole

Clotrimazole is a drug for local (outer) treatment of fungal diseases of the skin and mucous membranes. Clotrimazole has antifungal, antibacterial, antiprotozoic (impact on the simplest, for example, on Giardia), including countercothermandum (trichomonas relate to the simplest).

How Clotrimazole is valid

The mechanism of the CLotrimazole action is that it affects one of the components of the cell membrane (membrane) of mushrooms, and its permeability changes. There are such cells required substancesAs potassium and intracellular phosphorus compounds, which leads to its decay. Clotrimazole acts mainly on growing and dividing microorganisms. Depending on its concentration in therapeutic preparation It suspends the development (fungistatic effect) or destroys (fungicide effect) of the mushroom cell. Clotrimazole also prevents the transformation of Candida mushrooms in mycelium (a mushroom, consisting of branched threads), capable of spreading into internal organs.

Strains of mushrooms having natural resistance (immunity) to Clotrimazole, are rare. Primary cleavage of clotrimazole is described only for some Candida mushroom strains.

Clotrimazole is also effective in relation to certain types of bacteria: Staphylococci, Streptococcus, Gardnell. In high concentrations, it can suppress the vital activity of vaginal trichomonas.

The drug is poorly absorbed through the skin and mucous membranes, accumulating in the uppermost layer of the skin and mucous membranes.

In the process clinical studies No carcinogenicity was identified (the ability to cause malignant diseases), mutaging (exposure not genes and the emergence of new properties of the body), and for fertility (birth ability). But for laboratory Research Disorders were discovered in pregnant rats (impact on the fruit) when taking clotrimazole inside.

For some diseases, Clotrimazole can be used

Clotrimazole is applied externally with such fungal diseases of the skin and mucous membranes, like a dermatomycosis, dermatophytium, triphides, epidermofilation, microsporia, candidation, interpalic fungal erosion, fungal paronychia, micoses complicated bacterial infection, multicolored lichen , Erytrazm, Candadodose Stomatitis, Candadodic Vulvovaginitis, Trichomoniasis. In addition, it is used to renowned tributes before childbirth.

Contraindications for Clotrimazole

Like any drug TreatmentClotrimazole has its own contraindications:

Clotrimazole side effects

Clotrimazole can cause allergic reactions that are manifested in the form of itching, burning, redness and skin edema, the appearance of blisters, irritation and peeling on it. On the mucous membranes, allergies can also be shown through itching, burning, redness and swelling mucous membrane,

Being one of the most effective antifungal drugs, Clotrimazole is prescribed when complex treatment Different skin infections that are caused by excessive reproduction of Corynebacterium Minutissimum and Malassezia Furfur. Having a simple method of application and a significant content of the active substance in the composition of the drug, clotrimazole is perfectly transferred to patients even with high sensitivity and has a small number of contraindications to use.

In the article, we will consider instructions for use, the price, the analogues of the Clotrimazole and the reviews of him doctors and patients.

Features of the drug

This drug has the greatest impact in the development of diseases caused by mold, yeast mushrooms, as well as dermatophytes and other pathogens, which are sensitive to the effects of clotrimazole - active substance of the drug.

The fact that the drug is Clotrimazole, look in the video below:

Clotrimazole composition

The main active substance is Clotrimazole, which in 1 g of means contains 10 mg (refers to the recalculation of dry substance 100%). The auxiliary components include the following components:

• polyethylene glycol cetostearyl ether;
• propylene glycol;
• alcohol cetostearyl;
• polyethylene glycol 400;
• proxanol 268.

Externally, the drug is an ointment white color, homogeneous consistency having a weak specific drug smell.

Medicinal forms

On sale the drug is offered in the form of a tube of aluminum with bushons having an inner coating of varnish, which has tolerance to use. Tuba with a leafle of the liner describing the composition and method of application are in the cardboard packaging.

Also Clotrimazoles are also selling in the following sections:

• vaginal tabletshaving appearance Par Allepiped with several rounded corners. They contain in the composition of 100 mg of the active substance. In the blister they are 6 pieces;
• ointment (cream)having white color and homogeneous consistency for outdoor use. The active substance in ointment is 10 mg per 1 g of ointment. Ointment is packaged in a tube of 30 g, 20 g. Vaginal cream 2% is offered in tubes of 50 g;
• solutionused also for outdoor use. The solution (1%) was packaged into the orange vials and the volume of them can be 15 or 30 ml.

The cost of the drug may vary: Tablets Vaginal pharmacies are offered at a price of 35 to 60 rubles. A solution of various volumes - at a price of 96 to 123 rubles per vial, and ointment - as well as depending on the volume of tuba at a price of 180-215 rubles.

pharmachologic effect

The feature of Clotrimazole should be considered its rapid penetration into the upper layer of the epidermis and the instant start of exposure to yeast mushrooms. At the same time, the speed of reproduction of mushrooms is sharply limited, the possibility of further distribution is reduced and improvements in the skin condition appear.

Pharmacodynamics

Clotrimazole, penetrating into the skin for 30-45 minutes after its application, the cellular membranes of mushrooms are destroyed, preventing absorption of nutrients from the environment. Without a negative impact on the composition of the blood, the drug penetrates into all layers of epidermis and adversely affects the colonies of Corynebacterium Minutissimum and Malassezia Furfur.

Pharmacokinetics

Thanks to the rapid absorption speed in the skin of the active substance of the drug, the most rapid effect on the cause of the disease is the result: the skin is cleared, its surface is aligned and the functions are restored.

Disintegration of the decomposition of the drug is carried out by the kidneys. Negative impact on the body when absorbing the means in the absence increased sensitivity Cleaning to the components of the Clotrimazole has not been detected.

The active substance can penetrate the fabrics of the placenta and penetrate the fetus body, for this reason, it takes a neat prescription of clotrimazole during pregnancy or under the assumption of pregnancy. Pregnant women of the drug can be used in the case where the benefits exceeds the likely negative consequences for the fetus. When breastfeeding, Clotrimazole is prescribed as needed; Before feeding, the mammary glands should be carefully wiped in order to avoid the drug in the newborn body.

From what, except fungus, Clotrimazole helps, tells this video:

Indications

Clotrimazole is prescribed with many lesions of the top layer of the skin. Due to the high activity of the active substance, it is rapid effect on the foci of infection and a noticeable improvement in the condition of the skin after 1.5-2 weeks from the start of the use of the means.

The drug is prescribed in the presence of the following diseases and states:

• skin infections, which are caused by mold, yeast and other mushrooms, as well as dermatophytes and other types of pathogens;
• diseases that arose in the layers of the skin under the influence of excessively active reproduction in it Corynebacterium minutissimum (eritresmas) and Malassezia Furfur (multi-colored);
• for inflammation therapy;
• in the treatment ,.

Typically, the drug is recommended by a dermatologist, which, in the preparation of the treatment regimen, takes into account the overall condition of the body, the presence of increased sensitivity to the drug component, but Clotrimazole is sold in pharmacies without the need to present a recipe, which allows it to be used in the presence of pronounced skin lesions on their own. Mandatory in this case is a thorough study of the attached instructions.

Instruction

Before applying the antifungal drug under consideration, it is necessary to carefully clean the surface of the affected skin using soap and a large amount of water. The pH indicator should be neutral. After that, dry the skin and put on the affected sections of the ointment (cream), which is evenly distributed over it. The number of ointments depends on the area of \u200b\u200blesion.

After application, the ointment should be linted slightly: it will allow it faster to absorb and increase the degree of acting of the active substance. The first manifestations of skin condition are usually started manifest after 1.5-2 weeks from the start of treatment. Also, the final effect depends on the degree of skin lesion and its susceptibility to the active substance.

After the first manifestations of improvement, it is recommended to continue the use of the drug for another two weeks to secure the resulting effect.

Depending on the type of disease, the duration of treatment is prescribed:

• with multi-colored lisp ointment, 1-3 weeks are used;
• with dermatomycosis of various origin - 3-4 weeks;
• in the treatment of erytresses, 2.5-4 weeks of clotrimazole are usually sufficient.

If there was no pronounced improvement in the skin of the skin after 4 weeks of continuous use of the drug, you should report this to a dermatologist and introduce adjustments to the proposed treatment regimen.

In the presence of violations of the functions of the liver or kidneys, the dose used is not changed.

Contraindications

• Excessive sensitivity to the active substance of the drug or to other components should be considered contraindications to the use of clotrimazole.
• It should also be observed with certain caution when prescribing the drug during pregnancy and breastfeeding.

Side effects

The most frequent side effects using Clotrimazole usually include:

special instructions

Pregnancy and breastfeeding are special cases in which to show special caution When the clotrimazole is prescribed. With manifestation more benefit For a pregnant woman than the negative effect of the drug on the fruit of Clotrimazole can be appointed, but should be constantly under the supervision of the doctor.

Interaction with other medicines

Strengthening the antifungal effects of increased concentrations of hydroxybenzoic acid propyl ether makes it possible to use these substances together without lowering the effect of exposure. However, Clotrimazole reduces the degree of exposure to Nistatan, amphotericin, natamycin.

When using Clotrimazole in significant concentrations on the affected skin, increases its degree of efficiency.

Ether extract sage.

Structure Cream 1%: Clotrimazole at a concentration of 10 mg / g, zetostearyal and benzyl alcohols, polysorbate 60, synthetic spermacet, octyldodekanol, sorbitan stearate, water.

Structure mazi 1%: Clotrimazole in concentration of 10 mg / g, polyethylene oxide 400 and 1500, propylene glycol, methylparaben, nipagin.

Structure Solution 1%: Clotrimazole in concentration of 10 mg / ml (in terms of dry substance), polyethylene glycol 400, propylene glycol, ethanol 96%.

Structure candles: In one suppository, 100 mg of the active substance is contained and the basis in the amount necessary to obtain a suppository weighing 2 g. As the base of the CLotrimazole candles contain semi-synthetic glycerides.

Structure tablet: 100, 200 or 500 mg of clotrimazole, lactose in the form of monohydrate, potato starch, adipic acid, sodium bicarbonate, silica in colloidal form, sodium lauryl sulfate.

Form release

• gel 1% (package 20 and 40 g);
• cream 1% (tubes 15, 20, 30 and 50 g);
• 1% ointment (tubes 15, 20, 30 and 40 g);
• 1% solution (50 ml bottles);
• vaginal suppositories 0.1 g (package number 6);
• vaginal tablets 0.1, 0.2 or 0.5 g (Packaging No. 1, No. 3, No. 6; Tablets are equipped with an applicator).

Clotrimazole tablets and vaginal candles have different from other drug forms of the ATH code - G01AF02.

Clotrimazole can also be produced in the form of granules, powder for outdoor use, spray.

The drug is intended for local (including intravaginal) and outdoor use, the reception tablets are not available.

pharmachologic effect

Antimicotic.

Pharmacodynamics and pharmacokinetics

Clotrimazole is a derivative imidazole. .

In vitro shows high activity against the most pathogenic fungi which are able to cause serious infectious complications, namely:

• dermatophitis (Microsporum Sp., Epidermophyton Floccosum, Trichophyton Sp.);
• yeast-like mushrooms (Cryptococcus Neoformans, Candida Sp.);
• dimorphic mushrooms (Histoplasma Capsulatum, Paracoccidicides Brasiliensis, Coccidiodes Immitis).

The mechanism of Clotrimazole's action is based on its ability to block proteins synthesis, nucleic acids and ergosterol mushrooms needed for the construction of cell membranes. As a result, cell shells of mushrooms are damaged, and the cells die.

In low concentrations of Clotrimazole, fungistatically acts. If the dose is greater than 20 μg / ml, the drug has a fungicidal effect, not only on proliferating cells.

In the case of high doses, it helps to increase the concentration of hydrogen peroxide in the fungal cell to toxic value and, as a result, the destruction of fungal cells

Under the local application, the drug is absorbed epidermis . The highest concentration of the substance is determined in reticuloderme . It is also capable of penetrating the keratin nails.

In the system circulation, Clotrimazole falls in very minor quantities. Metabolized in the liver to inactive substances, which are derived from the body with feces and urine.

When intravaginal use, it is absorbed from 5 to 10% clotrimazole. Metabolization The absorbed substance is subjected to liver. Displays the products of metabolism with bile.

Indications for use: What is the ointment, cream, gel, candles and clotrimazole tablets?

What do clotrimazole ointment, gel, cream and solution help?

The drug is prescribed for treatment fungal skin infections caused by mold and yeast fungi , dermatophitis And other sensitive to Clotrimazole pathogens.

They are also used as funds from lisha caused Malassezia furfur., I. erytasm (pathogen - Corynebacterium minutissimum).

Ointment, cream, gel and clotrimazole solve: from Fungus nail ( , fungal paronychia ), trikhofiti. , dermatophytium , fungal erosion and diaper candida , , , dermatomicosis complicated secondary pyodermia of mycoses .

Indications for the use of ointments, gel, cream and mortar are including infectious diseases, pathogens that are resistant to and a number of other antifungal agents.

For treatment pink linga The drug is not suitable, since this disease is most likely to have virus or infectious allergic origin And may also be a response of the body on a strong shock or a nervous breakdown. Clotrimazole is effective when fungal lesions .

Application Mazi Clotrimazole, gel and cream with clotrimazole in gynecology shows:

• for treatment and prevention ;
• for prophylaxis repeated fungal infections of the female sexual system which develop with long-term treatment with antibiotics or against immunodeficiency states.

Also, the solution, gel, cream and ointment in gynecology are used to rehabilitate the genital paths before the delivery.

Candles - what are they from?

Indication to the use of vaginal suppositories is vaginal candidiasis and genital superinfections provoked by microorganisms sensitive to clotrimazole. The drug is appointed to women and - after the start of sexual life - teenage girls.

What is Clotrimazole Tablets?

Clotrimazole in tablets is used to treat blastomicotic infections are vulva and vagina . In particular, the drug is prescribed with the genus of the genus Candida vaginity (including diseases caused by which are resistant to nitran strains) caused by other sensitive clotrimazole pathogens superinfections of genital organs For the reservation of the genital paths before the delivery.

Contraindications

Contraindication: hypersensitivity.

Side effects

Allergic reactions.

When applied to the skin, the following side effects are possible:

• burning;
• edema;
• the appearance of blisters;
• skin irritation;
• feeling tingling
• peeling.

Local use for urogenital Mikosakh may be accompanied by burning, itching, swelling and hyperemic mucous membrane, intercurrent cystitis , the appearance of the discharge from the vagina, the increase in urination, pain during intercourse.

Under local application mikosakh oral cavity A redness of the mucous membrane can be marked, the feeling of tingling and burning in the place of applying the drug, irritation.

Clotrimazole application instructions: Clotrimazole for women and men

Clotrimazole ointment: instructions for use. How to apply clotrimazole ointment for men?

Before applying clotrimazole ointment (acre or other manufacturers), the affected parts of the body are pre-washed with soap water and carefully dry.

The drug is applied to the affected areas (capturing small areas of healthy skin around the lesion focus) with a thin layer from 1 to 3 r. / Day. And slightly rubbing.

For 1 processing area size with palm 5-thymillimeter strips of ointments.

Regardless of how the pathogens are caused by the disease, treatment after the relief of subjective symptoms is recommended to continue for another 2 weeks.

For dermatomycosis The course of treatment lasts from 3 to 4, with eryrazme - from 2 to 4, with - from 1 to 3 weeks.

If there is no clinical improvement after 4 weeks of regular use of the drug, the patient is sent to repeated microbiological research and revise the treatment regimen.

Use of ointments milk women makes it possible to block the propagation of fungal cells and - when appropriate, higher doses - ensures their complete destruction. In the therapeutic purposes of Clotrimazole from thrush Use 2 r. / day., rubbing ointment in the affected crotch seats.

For men, the method of use when milk and others (candadose Balanopostite , urogenital candidiasis ) The same as for women.

Ointment is applied to the extreme flesh and the head of the penis and gently rubbing into the skin and mucous membrane. Multiplicity of applications - 2 r. / Day.

The drug is badly absorbed into the skin, and its active substance It is characterized by the ability to gradually accumulate in the upper layer of the skin. Thanks to these properties, a high efficiency of Mazi Clotrimazole is ensured when milk In men and women.

Cream Clotrimazole: Instructions for use

The cream is designed for local applications. For milk and other fungal diseases He is applied to the affected fate twice or three times during the day and slightly rub.

The duration of the course depends on the testimony to use and is from 1-2 ( candidose Balant / Vulvite ) up to 3-4 weeks (with dermatomycosis ).

To prevent the recurrence of the disease, it is very important not to stop treatment for another 2 weeks after subjective infection symptoms disappear. In the absence of improvements after 4 weeks of therapy, the patient needs to consult a doctor.

The CLotrimazole vaginal cream is introduced into the vagina with portions of 5 grams 1 r. / Day. Within 3 days.

Instructions for mortar

Before the application of Clotrimazole, the skin should be washed with warm soapy water (especially areas between the fingers) and dry well. The processing of affected areas is carried out 2-3 rubles / day. The amount of solution should be sufficient for uniform application to the entire affected surface.

With damage to the skin stop solution, liquid clotrimazole must be applied to the Mosley of each wash.

The solution is the most preferred dosage form when onychomikosis . This is due to the fact that it has the best penetrating properties.

For fungal lesions of oral cavity The affected parts of the mucosa are treated with a cotton wand or a tampon, which is pre-applied drops (for processing each ear, from 10 to 20 drops). The multiplicity of procedures is 3-4 rubles / day.

After the application of Clotrimazole, within an hour, it is necessary to refrain from eating food and beverages.

Clotrimazole drops are also effective when oNOMICOSE caused by yeast mushrooms. Drops in the ear are administered using turtle: twisted cotton harness is wetted in solution and 3-4 r. / Day. Layout 5-10 minutes in a hearing pass. Treatment lasts from 3 to 4 weeks.

Instruction on gel

Feature given dosage form It is that the gel is well distributed on the skin and is also well absorbed into it. This allows the preparation to be used including for processing hard-to-reach parts of the body.

Intravaginally gel is used in the same way as Cream with Clotrimazole: 1 r. / Day. 5 grams. The course of treatment is 3 days.

Vaginal Tablets Clotrimazole: Instructions for use

In the absence of other appointments of the Tablet Clotrimazole Acry and synonymous drugs with milk and others fungal infections of genital organs Apply:

• within 3 days, 1 tablet 2 p. / day;
• within 6 days, 1 tablet 1 r. / day.

How to enter vaginal clotrimazole tablets? Before administration, the tablet is removed from the packaging and wetted by cooled water. Enter the drug follows the "lying on the back" position with legs bent.

In order for the tablet completely dissolved, and Clotrimazole affects, a wet environment is needed (otherwise insoluble particles can be saturated outward). Therefore, the tablet is introduced into the vagina as closely as possible. Optimally carry out the procedure before bedtime.

Treatment must be stopped before menstruation. Menstrual allocations will wash the drug, and it will not have the necessary action. During the period of treatment, vaginal pills should not use tampons, spermicides, intravaginal dying and any other vaginal products.

For sanitation of sex tract A 200 mg of Clotrimazole is introduced to the female consequence.

For pregnancy the drug is contraindicated in 1 trimester. At the later terms, Clotrimazole does not adversely affect the development of the fetus, but the use of the applicator can be associated with certain risks.

Instructions for candles

Candles OT thrush It is used intravaginal. The drug should be introduced deep into the vagina, one daily for 6 days. Repeated courses are possible after consulting a doctor.

Candles Clotrimazolence milk and others urogenital Mikosakh Do not apply during menstrual bleeding. Treatment must be completed before it starts.

During pregnancy, the drug in this dosage form is used from the 2nd trimester and in situations where the expected benefit for the mother exceeds possible risks For fetal.

Reviews make it possible to conclude that the drug quickly destroys the colonies of mushrooms and eliminates the unpleasant symptoms of mycoses. Its advantages include a low price and a large selection of dosage forms.

Overdose

When applied to the skin and intravaginal use, there is no risk of acute intoxication, since Clotrimazole enters systemic blood flow in very small quantities.

In case of accidental treatment of clotrimazole inside, nausea, anorexia, vomiting, gastralgy, liver dysfunction are possible. In rare cases, pollakiuria, hallucinations, drowsiness, skin allergic reactions are noted.

In this case, the patient is prescribed enterosorbents and symptomatic treatment. The stomach washing is carried out in situations where the dose-threatening dose has been accepted during the previous hour, as well as in the presence of visible symptoms of overdose (nausea, dizziness, vomiting).

Interaction

With simultaneous use with polician antibiotics ( , , ) Preparations mutually suppress each other's activity.

Terms of sale

Without recipe.

Storage conditions

Take care of moisture and light. The storage temperature should not exceed 25 ° C. Freezing cream, gel, ointment or solution is not allowed.

Shelf life

Suppositories, cream, solution, gel and vaginal pills are suitable for use for 3 years after the release date. Shelf life for ointments - 2 years.

special instructions

Avoid swallowing and getting into the eyes.

In case of methods, all the affected parts of the body should be treated.

The use of vaginal tablets, if the doctor did not give other recommendations, is contraindicated in the presence of any of the following symptoms:

• aciquulous vaginal bleeding ;
• bloody separated or pathological bleeding from the vagina, uterine hemorrhages;
• dizuriy ;
• lower abdominal pain;
• open wounds, bubbles or ulcers vagina or vulva;
• any unpleasant symptoms that are associated with the use of clotrimazole (irritation, redness, burning, swelling, etc.);
• chills or fever with an increase in temperature above 38 ° C;
• nausea and / or vomiting;
• vaginal discharge with an unpleasant odor;
• pain in the shoulder area or back.

To prevent reinfection, treatment is prescribed both partners simultaneously. Optimal dosage form for men - cream.

For In addition to the preparation, chemotherapeutic means for systemic treatment are prescribed ( inside).

What is the better ointment or cream Clotrimazole?

The choice in favor of a particular dosage form is made depending on the indications. Clotrimazole ointment for women and men is prescribed for diseases that are accompanied by increased dryness and peeling of the skin.

As a rule, this is caused by skin mica dermatophyphites ( trikhophysu , microsporia ), erytrazm , few-shaped lichen , individual cases

Candid It is synonymous with Clotrimazole. The basis of both drugs is the same substance, therefore there are no fundamental differences between them.

Clotrimazole or pimafucin - what is better?

Main component — antibiotic antimicotic action Nitamicine . Sensitivity to the drug show mainly mold and yeast mushrooms (including childbirth Penicillium, Candida, Cephalosporium, Aspergillus and Fusarium.).

Less sensitive k. Pimafucin are Pseudoallescheria Boydii. and dermatofitis . That is, in situations, when the cause of the disease is fungi genus Epidermophyton., Trichophyton or Microsporum.The choice should be made in favor of the drug Clotrimazole.

The use of clotrimazole less frequently accompanied by hypersensitivity reactions. In addition, he is less likely than Pimafucin , provokes violations of the microflora balance of genital organs.

Clotrimazole for children

Experience in the use of solution, ointments, gel and cream 1% in children are absent.

Tablets are used since 12 years later, under the condition of the patient menarche .

Candles for children are not prescribed.

Clotrimazole during pregnancy and lactation

Cream, gel, ointment, solution, candles and wag. Tablets during pregnancy can be used with 2 trimesters.

Strictly controlled studies regarding the safety of application during pregnancy, in connection with this, Clotrimazole is not prescribed in 1 trimester.

Clinical studies regarding the influence of the drug on Women were not carried out, there were no adverse effects in animal experiments.

Clotrimazole tablets and candles for pregnancy (in 2 and 3 trimesters) do not have a negative effect on the fruit, but the use of the applicator may be dangerous.

For breastfeeding The drug is used with caution, since it does not know whether it penetrates into milk.

Fungal infection does not always proceed independently. Often it is a sign of a severe course of other diseases. Sometimes people take the mycotic lesions for cosmetic defects, for example, peeling of the toes, curvature and cracks of nails. But in most cases it is a fungus. With vaginal candidiasis, it can be a combination of fungus with bacterial infection. Therefore, self-diagnosis is unacceptable and may be inaccurate. It is important to visit the profile doctor for conducting a survey.

Those who faced the manifestations of the thrush, and to whom Klotrimazole are appointed, of course you are interested - how long has the gynecology uses this medicine, is it well helps a cryotrycarotic ointment, how to correctly smear, how often to use whether it is able to serve as a means of prophylaxis if used as Intimate lubricant, is there a better medicine?

How is the infection of fungus

Mushrooms are isolated into a separate kingdom, which occupies an intermediate position between plants and animals. They are not able to move as plants and do not have chlorophyll, but are capable of producing nutrients from water and carbon dioxide. The metabolism is largely reminded by animals, but mushrooms have no muscles and nerve cells. The outer shell forms a chitin, resembling a protective insect shell.

In severe mushroom conditions, disputes are capable of forming. They can for a long time To be in sleep, until the conditions allow them to go into an active form.

The following forms of fungal infection can develop in humans:

• candidiasis - affects the mucous membranes of the vagina, digestive tract, skin folds;
• trikhophysu - develops on the skin, nails and mucous membranes;
• cryptococcosis - localizes in the lungs and internal organs;
• aspergillosis is predominantly pulmonary infections.

Infection fungus can occur in various ways.

• Alimentary. The mouth cavity becomes an entrance gate of infection when using infected food. But children also have a mother's dairy iron, on the nipples of which there are cracks and candidiasis. The newborn has no protective properties of immunity, so they quickly develop candidal stomatitis.
• Air-dusty. In this way, systemic micoses are transmitted. But immediately after hitting Aspergilli or cryptococcus the disease does not occur. Previously need a critical decrease in immunity, as with HIV.
• Contact. In this way, any surface infection can be transmitted. Wearing infected shoes, public baths And pools can lead to the appearance of a fungus stop and nails.
• Paul. There is a place to distribute candidiasis. Moreover, men sick them extremely rarely, but act as a carrier. Among women clinical picture Very characteristic, but it may not develop immediately, but in immunity failures.

Treatment is carried out by local drugs, and with inefficiency - systemic. But they are very toxic, have a large amount of heavy side Effects. Not always treatment guarantees full deliverance from fungus. Often, vegetative forms are destroyed, and disputes are preserved to give rise to new fungi when weakening the body.

Features of the drug

Mushrooms differ in structure from bacteria. Therefore, antibiotics against them are ineffective. Preparations with antimicotic action are developed that are valid against fungus. "Clotrimazole" refers to imidazole compounds. Its action is associated with a violation of the synthesis of the main component of the mushroom cell wall - Ergosterina. This leads to an increase in the permeability of cells for fluid and ions, lysis (destruction) of fungi occurs. The effect depends on the concentration of the substance:

• in small doses - there is fungistatically - holds back the reproduction of the fungus;
• in large doses - fungiculate, kills microorganisms.

At high concentration, the impact is not only for dividing cells, but also to the rest. The drug acts on peroxidase enzymes, which leads to an increase in free hydrogen peroxide. It enhances the toxic effect on mushrooms.

"Clotrimazole" is produced in several forms:

• vaginal cream;
• ointment and cream for outdoor use;
• outer solution;
• vaginal tablets and candles;
• corger paste;
• spray.

Spectrum of activity

Main appointment various shapes Preparation - Treatment of fungal infection. But Clotrimazole acts against the pathogens of many diseases:

• yeast-like fungi;
• dermatomycetes (pathogens of triprophides and microsporia);
• multicolored pathogen deprived;
• bacteria (eritresses, staphylococci, streptococci);
• sex infections (trichomoniasis, gardnerellosis).

Mushrooms rarely meet natural resistance to the drug. But if often not completely undergoing the course of the treatment of candidiasis, then its pathogens are able to develop immunity to the medicine. So that the treatment has been effective against trichomonad, the maximum concentration of the drug is necessary.

pharmachologic effect

The medicine is valid at the place of application. "Clotrimazole" is poorly absorbed through the skin or mucous membranes. But it is able to accumulate in the horn layer, forming a dose there sufficient to suppress the fungus. It can also be used for nail processing.

In women using milk candles, absorption is absorbing 3-10% of the drug. Its metabolism occurs in the liver, while the system of microsomal oxidation is accelerated. Disintegrates are displayed through the intestines. In the vagina, the high concentration is preserved within 48-72 hours.

When you can use the medicine

Antimicotic is produced in several forms. Each of them is specially selected for ease of use. Indications for the use of "Clotrimazole" depend on its form. To navigate, in what cases and what can be started, will help the table.

Table - Basic Indications for Clotrimazole forms

Medication form	Dosage	Indications
Ointment	1% in a tub of 30 g	- fungal skin diseases, folds, stop; - Freedy-shaped lisha, erytraism; - Mycoses with secondary pyoderma (skin lesions)
Cream	2% in a tub of 50 g	- vaginal candidal infections; - Candadose vulvit; - superinfection of the vagina caused by sensitive bacteria
Vaginal tablets	100 mg in 1 tablet	- Treatment of vaginal candidiasis; - prevention of the recurrence of the candidiasis or the occurrence of the disease; - Sanitation of the genital paths in front of gynecological procedures
Vaginal candles	100 mg in 1 candle	- Candadose vulvit; - Candidal vulvovaginit
Solution	1% in bottles with drops of 15 ml	- infections of the mucous membrane; - Mycoses Stop, nails or palms; - Trikhofitosis; - head dermatomycosis, torso, pah region; - Freedy Deliches and Erytrazm

Some skin pathology Can be able to exercise their inertia. Under fungal defeat Psoriasis may be masked. With a pronounced decrease in immunity, the candidal vaginite may complicate the outbreak of genital herpes.

Instructions for the use of "Clotrimazole" for different form of release

For each form of the drug, there are its own features of use. But before starting treatment, you need to visit the doctor. The choice of a specialist depends on the symptoms of the disease. If itching and burning appeared in the vagina, then the woman should visit the gynecologist. Those who are worried about the folds of the skin between the fingers or there is a suspicion of the nail fungus, you need a dermatologist. If a man has signs of urethritis - initial stage Inflammation, which can go to Balanit and Balanopostitis, need an inspection of a urologist. The choice of the most suitable drug will make a doctor.

Vaginal medicines

For the treatment of vulvovaginal candidiasis or color, candles, tablets and cream use candles. The medicine in the form of candles or cream is only characterized by the composition of auxiliary substances. The suppositories are solid fat, which at the body temperature begins to melt and envelop the mucous membrane. Tablets should be dissolved in sex paths.

Candles (tablets) are introduced one at night deep into the vagina. The course of treatment lasts six days. Treatment need to be carried out as early as possible before menstruation. Use Clotrimazole during menstruation during menstruation. Sometimes with a pronounced infection, the doctor can recommend to lay candles twice a day.

For the reservation of the generic paths is enough single tablet or suppository laid on the night.

"Clotrimazole" for pregnant women is allowed in vaginal form, but only in the second and third trimester. The active ingredient is practically not absorbed and quickly metabolized. Therefore, it is allowed to use candles with breastfeeding, but after consulting with the doctor.

Vaginal cream can be used on a par with suppositories. It should be carefully related to the dosing of the drug. In 1 g of cream contains 20 mg of the active substance. To create a sufficient concentration into the vagina, you need to introduce at least 5 g. The duration of the course is one or two weeks. Women are encouraged to carry out the treatment of thrush "Clotrimazole" once a day, and men with candidadose dust shall apply two or three times a day.

Side effects develop in the form of local reactions:

• redness;
• eyefather of the mucosa of the vagina;
• peeling of the skin;
• popper pain.

Manifestations side effects - this is allergic reaction, Individual intolerance to the drug. Overdose of candles or tablets does not occur. Perhaps erroneous use of inside, which is accompanied by:

• pain in the stomach;
• nausea;
• vomit;
• violation of the liver;
• hallucinations;
• drowsiness.

In the poisoning "Clotrimazole", stomach and symptomatic therapy is carried out. But if unpleasant symptoms appeared when proper use Medications, then this individual intolerance, from such treatment will have to refuse.

Solution

"Clotrimazole" in liquid form applies only as an outdoor. To do this, there are several drops of medicine on the skin, affected by the fungus and are thoroughly rubbed. Optimally do it two or three times a day. The course lasts about four weeks. It is important to continue treatment, even when the first signs of the disease disappeared.

If mycosis developed in the footsteps, then the solution is applied after each feet washing. Very carefully handle interfallated gaps. It is forbidden to apply a means for an occlusive (sealing) bandage.

The side effects of Clotrimazole are rarely manifested, but it can be:

• dermatitis;
• hives;
• rash;
• erythema;
• peeling;

Among the features of applying a ban on the use of eye. Even with a strong itching area, the defeat cannot be scratched and scratching. This leads to the spread of infection. After washing, the affected skin should be thoroughly dried. Clothes that come into contact with the foci should be daily changed and washed at a temperature of 90 ° C.

Ointment

The use of Mazi "Clotrimazole" is possible only externally. Skin areas affected by fungus are pre-washed with a neutral soap or a gel for washing and thoroughly dried. Ointment is applied two or three times a day.

With a delay, pigment stains are treated for one to three weeks. For other dermatomycosis you need up to four weeks so that the treatment seemed effective. With damage to stop, the ointment is continued for two weeks after the disappearance of symptoms.

In order for the treatment of onychomicosis (fungal damage to the nail) to be effective, it is necessary to ensure that the nails are briefly cut, and their surface was rough. This increases the permeability for the medicinal product.

Who can not

"Clotrimazole" refers to drugs, contraindications to which are presented with a minimum list:

• individual intolerance;
• first trimester of pregnancy.

Women during breastfeeding is needed by a doctor's advice before treatment. Patients S. hepatic insufficiency We must periodically pass biochemical analysis blood to control her work. With the appearance of deterioration, treatment is stopped.

"Clotrimazole" is not used for oral cavity, especially in infants. For this, nystatin is used, which is dissolved, and in children - processing with soda mortar.

Carefully need to approach the combination of different medicines. Other antifungal drugs, such as Nystatin, Amphotericin B, Natamicin, reduce the effectiveness of Clotrimazole. According to the reviews of doctors, while using the Tharolimus immunosuppressant simultaneously with the vaginal form of antimicotics, it is possible to increase the concentration of the first in the blood, which will require changes to the dosage.

Analogs

"Clotrimazole" is widespread antifungal drug. But its existing analogues on the active substance:

• "Candid" - cream, solution, powder;
• "Caurent" - cream, spray;
• "Candibane" - cream;
• "Clotrimazole hexane" - cream.

There are also analogues on the principle of action. These include:

• "Bifunal" - cream;
• "Myxpore" - cream;
• "Zalayan" - cream;
• "Mikogel" - gel.

For many fungal diseases, prevention is important. This particularly concerns people who have a predisposition to the fungus. Diabetes suffering from excess weights in the places of appearance of diameters notice the white flare. This is fungal defeat. To prevent it, it is necessary to carefully select the treatment of the main disease.

It should also be remembered that the infection of the fungus stop can occur in in public places and from someone else's shoes. Therefore, you should not walk barefoot in the pool, bath or shower.

Reviews about Clotrimazole Candle talk about the effectiveness of the drug. But for women, it is important for the period of treatment to abandon sexual contacts, use natural cotton underwear and observe a diet with a reduced carbohydrate content and a large number of ferocular products. With frequent relapses, it is necessary to consult a doctor for the appointment of anti-inflicted treatment, which lasts at least six months.

Reviews: "The price is very acceptable"

Excellent drug in the fight against fungus! When diagnosing a fungal disease on genitalia in the form of ointments, it works gorgeous! The price is very acceptable!
After applying, it spreads greatly, may leave tracks! Well, it is important, probably, only for urological patients, as the application during the day gives the extreme inconvenience!

Semesendyaev R. I., Urologist, https://protabletky.ru/clotrimazole/#otzivi.

Injured nail thumb on the foot. Nail candidiasis began. I tried to be treated independently using iodine and hydrogen peroxide. The effect was, but minimal. After the start of the use of clotrimazole, the rotting and decomposition of the nail stopped and slowed down. However, it is not necessary to talk about 100% treatments.

Andrey P., https://protabletky.ru/clotrimazole/#otzivi